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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Biomedical engineering. ; Radiology. ; Bioinformatics. ; Biotechnology. ; Biomedical Engineering and Bioengineering. ; Radiology. ; Computational and Systems Biology.
    Description / Table of Contents: Deep Learning in Medical Image Analysis -- Medical Image Synthesis via Deep Learning -- Deep Learning for Pulmonary Image Analysis: Classification, Detection, and Segmentation -- Deep Learning Computer Aided Diagnosis for Breast Lesion in Digital Mammogram -- Decision support system for lung cancer using PET/CT and microscopic images -- Lesion Image Synthesis using DCGANs for Metastatic Liver Cancer Detection -- Retinopathy analysis based on deep convolution neural network -- Diagnosis of Glaucoma on retinal fundus images using deep learning: detection of nerve fiber layer defect and optic disc analysis -- Automatic segmentation of multiple organs on 3D CT images by using deep learning approaches -- Techniques and Applications in Skin OCT Analysis -- Deep Learning Technique for Musculoskeletal Analysis -- Index.
    Abstract: This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems. Each of its chapters covers a topic in depth, ranging from medical image synthesis and techniques for muskuloskeletal analysis to diagnostic tools for breast lesions on digital mammograms and glaucoma on retinal fundus images. It also provides an overview of deep learning in medical image analysis and highlights issues and challenges encountered by researchers and clinicians, surveying and discussing practical approaches in general and in the context of specific problems. Academics, clinical and industry researchers, as well as young researchers and graduate students in medical imaging, computer-aided-diagnosis, biomedical engineering and computer vision will find this book a great reference and very useful learning resource.
    Type of Medium: Online Resource
    Pages: VIII, 181 p. 131 illus., 114 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030331283
    Series Statement: Advances in Experimental Medicine and Biology, 1213
    DDC: 660.6
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Biomaterials. ; Mathematical models. ; Dentistry. ; Biomedical engineering. ; Biotechnology. ; Biomaterials. ; Mathematical Modeling and Industrial Mathematics. ; Dentistry. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1 - Systematic Errors in Longitudinal Measurements -- Chapter 2 - Endodontic Treatment and Vertical Root Fracture -- Chapter 3 - Debonding of Resin Composite Restorations -- Chapter 4 - Attenuation of Curing Light through Resin Composite Restorations -- Chapter 5 - Release of Ions or Molecules from Dental Restorations -- Chapter 6 - Heat Generated from Dental Resin Composites during Curing -- Chapter 7 - Mechanical Failure of Dental Restorations – The Weakest-Link Theory -- Chapter 8 - Stability of Dental Implants -- Chapter 9 - Kinetics of Photo-polymerization -- Index.
    Abstract: This book presents a mechanistic approach—mathematical modeling—for carrying out dental materials research. This approach allows researchers to go beyond the null hypothesis and obtain a solution that is more general and therefore predictive for conditions other than those considered in a study. Hence it can be used either on its own or to complement the commonly used statistical approach. Through a series of practical problems with wide-ranging application, the reader will be guided on: How to construct a mathematical model for the behavior of dental materials by making informed assumptions of the physical, chemical, or mechanical situation How to simplify the model by making suitable simplifications How to calibrate the model by calculating the values of key parameters using experimental results How to refine the model when there are discrepancies between predictions and experiments Only elementary calculus is required to follow the examples and all the problems can be solved by using MS Excel© spreadsheets. This is an ideal book for dental materials researchers without a strong mathematical background who are interested in applying a more mechanistic approach to their research to give deeper insight into the problem at hand. Advance praise for Mathematical Models for Dental Materials Research: “This is a nice addition for research students on how to conduct their work and how to manage data analysis. It brings together a number of important aspects of dental materials investigations which has been missing in the literature. The practical examples make it much easier to understand.” – Michael F. Burrow, Clinical Professor in Prosthodontics, The University of Hong Kong “The great strengths of this volume are the real world examples of dental materials research in the successive chapters. In turn, this is an outcome of the outstanding expertise of both authors. I warmly recommend this book to the dental biomaterials community worldwide.” – David C. Watts, Professor of Biomaterials Science, University of Manchester, UK.
    Type of Medium: Online Resource
    Pages: XIV, 77 p. 41 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030378493
    DDC: 660.6
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Neurosciences. ; Medical care. ; Neurology . ; Biomedical engineering. ; Biotechnology. ; Neuroscience. ; Health Care. ; Neurology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1: Application of reinforcement and deep learning techniques in brain machine interfaces -- Chapter 2: Specific muscle activation patterns in athletic and orthopedic populations: considerations for using surface electromyography in assistive and biofeedback device applications -- Chapter 3: Kineto-dynamic modeling of human upper limb for robotic manipulators and assistive applications -- Chapter 4: Learning from the human hand: force control and perception using a soft-synergy prosthetic hand and non-invasive haptic feedback -- Chapter 5: Design of a soft glove-based robotic hand exoskeleton with embedded synergies -- Chapter 6: Model predictive control based knee actuator allocation during a standing-up motion with a powered exoskeleton and functional electrical stimulation -- Chapter 7: Deep brain stimulation for gait and postural disturbances in Parkinson’s disease -- Chapter 8: Cognitive and physiological intent for the adaptation of motor prostheses -- Index.
    Abstract: This book provides a comprehensive review of recent developments in the field of motor neuroprosthetics and brain-machine interfaces. Chapters in this book are provided by leading experts in the field and include topics such as the design and control of multidimensional prosthetics and exoskeletons, deep brain stimulation, functional electrical stimulation, deep learning for brain machine interfaces, biofeedback, and cognitive intent for adaptation of motor prostheses. This book is a great resource for undergraduate and graduate students, researchers, engineers from related disciplines, entrepreneurs, and anyone interested in the latest progress in the field of motor neuroprostheses.
    Type of Medium: Online Resource
    Pages: XII, 162 p. 57 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030387402
    DDC: 660.6
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Cancer. ; Microtechnology. ; Microelectromechanical systems. ; Biomedical engineering. ; Biotechnology. ; Cancer Biology. ; Microsystems and MEMS. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Part 1 -- Conventional nanosized drug delivery systems for cancer applications -- Homing peptides for cancer therapy -- Radiolabeling of theranostic nanosystems -- Boosting nanomedicine efficacy with hyperbaric oxygen therapy -- Part 2 -- Mesoporous Silica Nanoparticles as Carriers for Biomolecules in Cancer Therapy -- Clearable Nanoparticles for Cancer Photothermal Therapy -- Biohybrid Nanosystems for Cancer Treatment: Merging the Best of Two Worlds -- Electrospun Nanofibers for Cancer Therapy -- Nanoneedle-based materials for intracellular studies -- Part 3 -- In vitro assays for nanoparticle-cancer cell interaction studies -- 3D tumor spheroid models for in vitro therapeutic screening of nanoparticles -- In vitro and in vivo tumor models for the evaluation of anticancer nanoparticles -- Part 4 -- Nanotechnology for the Development of Nanovaccines in Cancer Immunotherapy -- Viral nanoparticles: cancer vaccines and immune modulators -- Industrial Perspective on Cancer Immunotherapy -- Index.
    Abstract: The book covers the latest developments in biologically-inspired and derived nanomedicine for cancer therapy. The purpose of the book is to illustrate the significance of naturally-mimicking systems for enhancing the dose delivered to the tumor, to improve stability, and prolong the circulation time. Moreover, readers are presented with advanced materials such as adjuvants for immunostimulation in cancer vaccines. The book also provides a comprehensive overview of the current status of academic research. This is an ideal book for students, researchers, and professors working in nanotechnology, cancer, targeted drug delivery, controlled drug release, materials science, and biomaterials as well as companies developing cancer immunotherapy.
    Type of Medium: Online Resource
    Pages: VIII, 360 p. 80 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030581749
    Series Statement: Advances in Experimental Medicine and Biology, 1295
    DDC: 660.6
    Language: English
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  • 5
    Keywords: Biotechnology. ; Biomaterials. ; Biomedical engineering. ; Biotechnology. ; Biomaterials. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Insights into the emergence, clinical prevalence and significance of Staphylococcus aureus small colony variants -- Periprosthetic Joint Infection -- Complications in orthopedic trauma surgery: fracture related infection -- Chiral Stereochemical Strategy for Antimicrobial Adhesion -- Perspectives on and need to develop new infection control strategies -- Battling bacteria with free and surface-immobilized polymeric nanostructures -- Engineering Approaches to Create Antibacterial Surfaces on Biomedical Implants and Devices -- 3D Printed Ceramic-Polymer Composites for Treating Bone Infection -- Bioinspired interfaces for the management of skin infections -- Antimicrobial endodontic materials -- Local Delivery of Anti-biofilm Therapeutics -- Device-Related Infections -- Advances in polysaccharide based antimicrobial delivery vehicles -- Antibacterial Coatings on Medical Implants -- Perspectives on biomaterial-associated infection: pathogenesis and current clinical demands -- Polymeric Nanoparticulate Delivery Vehicles of Antimicrobials for Biofilm Eradication -- Pathogenesis of biomaterial-associated infection -- Metal- and Polymer-Based Nanoparticles for Advanced Therapeutic and Diagnostic System Applications -- Antimicrobial Material in Arthroplasty -- Antimicrobial Hydrogels: Key Considerations and Engineering Strategies for Biomedical Applications -- Antibacterial Polymeric and Peptide Gels/Hydrogels to Prevent Biomaterial-related Infections -- The Impact of Bacterial Biofilms in Transfusion Medicine -- Mechanisms of Action and Chemical Origins of Biologically Active Antimicrobial Polymers -- When the Race is Lost: The Clinical Impact of Prosthetic Joint Infections -- Antibacterial Hydroxyapatite: An Effective Approach to Cure Infections in Orthopedics -- Index.
    Abstract: This book covers the latest research in biofilm, infection, and antimicrobial strategies in reducing and treating musculoskeletal, skin, transfusion, implant-related infections, etc. Topics covered include biofilms, small colony variants, antimicrobial biomaterials (antibiotics, antimicrobial peptides, hydrogels, bioinspired interfaces, immunotherapeutic approaches, and more), antimicrobial coatings, engineering and 3D printing, antimicrobial delivery vehicles, and perspectives on clinical impacts. Antibiotic resistance, which shifts the race toward bacteria, and strategies to reduce antibiotic resistance, are also briefly touched on. Combined with its companion volume, Racing for the Surface: Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies, this book bridges the gaps between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in infection, microbiology, and biomaterials and devices.
    Type of Medium: Online Resource
    Pages: XI, 650 p. 158 illus., 122 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030344757
    DDC: 660.6
    Language: English
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  • 6
    Keywords: Biotechnology. ; Radiology. ; Biomedical engineering. ; Neurosciences. ; Biotechnology. ; Radiology. ; Biomedical Engineering and Bioengineering. ; Neuroscience.
    Description / Table of Contents: Electromagnetic Properties and the Basis for CDI, MREIT and EPT -- Modeling for Electromagnetic Characterization, Prediction and Reconstruction -- Magnetic Resonance Imaging Basics -- Phantom Construction and Equipment Configurations for Characterizing Electrical Properties using MRI -- MR Current Density and MREIT Data Acquisition -- Magnetic Resonance Current Density Imaging (MR-CDI) -- Magnetic Resonance Electrical Impedance Tomography -- Index.
    Abstract: This book covers the latest developments in tissue electrical conductivity and current density imaging, increasingly popular as well as challenging applications of MRI. These applications are enabled by the acquisition of high-quality MR phase images. This book provides a practical description of the MRI physics needed to understand and acquire phase images in MRI and the key details required to reconstruct them into conductivity, current density or electric field distributions. Comprehensive details are provided about the electrical properties of biological tissues, computational modeling considerations, experimental methods, construction of non-biological and biological phantoms and MRI pulse sequences. An inclusive review of image reconstruction algorithms, and their potential applications is provided for applications directed at determining current density or electric fields, such as in transcranial DC or AC stimulation techniques; as well as electrical conductivity reconstructions that may be of use in quantitative MRI applications used to detect cancer or other pathologies. This is an excellent book for undergraduate and graduate students beginning to explore phase, current density, and conductivity imaging in MRI, and will also be of great use to researchers interested in the area of MR-based electrical property imaging.
    Type of Medium: Online Resource
    Pages: VII, 206 p. 101 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031038730
    Series Statement: Advances in Experimental Medicine and Biology, 1380
    DDC: 660.6
    Language: English
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  • 7
    Keywords: Biotechnology. ; Biomaterials. ; Biomedical engineering. ; Biotechnology. ; Biomaterials. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Part I: Innovative antimicrobial and osteoinductive therapeutics -- Advances in antimicrobial and osteoinductive biomaterials -- Recent Advances in Controlled Release Technologies for the Co-Delivery of Antimicrobial and Osteoconductive Therapeutics -- Biofilm-inhibiting and osseointegration-promoting orthopedic implants with novel nanocoatings -- Three dimensional (3D) and drug-eluting nanofiber coating for prosthetic implants -- Cationic antimicrobial coatings with osteoinductive properties -- Peptide Functionalized Biomaterials with Osteoinductive or Anti-biofilm Activity -- Construction of bio-functionalized ZnO coatings on titanium implants with both self-antibacterial and osteoinductive properties -- Gasotransmitters: antimicrobial properties and impact on cell growth for tissue engineering -- Carbon nanotubes: Their antimicrobial properties and applications in bone tissue regeneration -- Part II: Interface tissue engineering and advanced material for scaffolds -- Fracture healing and progress towards successful repair -- Animal models for bone tissue engineering and osteoinductive biomaterial research -- Bioprinting in Tissue Engineering -- Additive Manufacturing of Bio-scaffolds for Bone Regeneration -- Anti-biofouling and Antimicrobial Biomaterials for Tissue Engineering -- Osteoinductive and osteoconductive biomaterials -- Bimetallic nanoparticles for biomedical applications: a review -- Peptide-mediated Bone Tissue Regeneration -- Antibody mediated osseous regeneration - a new strategy for bioengineering -- Extracellular matrix-based materials for bone regeneration -- Calcium Phosphate Biomaterials for Bone Tissue Engineering: Properties and Relevance in Bone Repair -- Bioactive Glasses in Orthopedic Applications -- Advances in Tissue Engineering and Regeneration -- SCAFFOLDS FOR TISSUE ENGINEERING: A state of the art review concerning types, properties, materials, processing and characterization -- Recent Developments of Zn-Based Medical Implants -- Recent physical interaction-based bioadhesives -- Tellurium, the forgotten element: a review for the properties, processes and biomedical applications of the bulk and nanoscale metalloid -- Index.
    Abstract: This book covers the key basics of tissue engineering as well as the latest advances in the integration of both antimicrobial and osteoinductive properties. Topics covered include osteoconductive and osteoinductive biomaterials (calcium phosphate, bone morphogenetic protein, peptides, antibodies, bioactive glasses, nanomaterials, etc.) and scaffolds. Research integrating both antimicrobial/biofilm-inhibiting and osteoinductive/osteoconductive properties and their co-delivery is detailed and their roles in clinical success are discussed. Combined with its companion volume, Racing for the Surface: Antimicrobial and Interface Tissue Engineering, this book bridges the gap between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in tissue engineering and regeneration, infection, and biomaterials and devices.
    Type of Medium: Online Resource
    Pages: XI, 809 p. 152 illus., 126 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030344719
    DDC: 660.6
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Regenerative medicine. ; Reproductive health. ; Stem cells. ; Cancer. ; Biomedical engineering. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Reproductive Medicine. ; Stem Cell Biology. ; Cancer Biology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1. Basic Concepts of Stem Cells: The Facts and Hype in Stem Cells Research and Development -- Chapter 2. Embryonic and Pluripotent Stem Cells -- Chapter 3. Adult Stem Cells: Hematopoietic Stem Cells, and Control Of Hematopoiesis -- Chapter 4. Adult Stem Cells: Adult Stem Cells: Mesenchymal Stromal Cells, Endothelial Progenitor Cells and Pericytes -- Chapter 5. Cancer Stem Cells and the Development of Cancer -- Chapter 6. Stem Cell Applications In Metabolic Disorders: Diabetes Mellitus -- Chapter 7. Epigenetics in Stem Cell Biology -- Chapter 8. Practicum: Isolation of Bone Marrow and Adipose Tissue Mesenchyme Stromal Cells -- Chapter 9. Induced Pluripotent Stem Cells: Biology, History and in-vitro Generation -- Chapter 10. Tissue Engineering Modalities and Nanotechnology -- Chapter 11. Practicum: Scaffold engineering using the amniotic membrane -- Chapter 12. The Scientific Method, Ethical Consideration and Implications in Stem Cell Research.
    Abstract: This textbook covers the basic aspects of stem cell research and applications in regenerative medicine. Each chapter includes a didactic component and a practical section. The book offers readers insights into: How to identify the basic concepts of stem cell biology and the molecular regulation of pluripotency and stem cell development. How to produce induced pluripotent stem cells (iPSCs) and the basics of transfection. The biology of adult stem cells, with particular emphasis on mesenchymal stromal cells and hematopoietic stem cells, and the basic mechanisms that regulate them. How cancer stem cells arise and metastasize, and their properties. How to develop the skills needed to isolate, differentiate and characterize adult stem The clinical significance of stem cell research and the potential problems that need to be overcome. Evaluating the use of stem cells for tissue engineering and therapies (the amniotic membrane) The applications of bio-nanotechnology in stem cell research. How epigenetic mechanisms, including various DNA modifications and histone dynamics, are involved in regulating the potentiality and differentiation of stem cells. The scientific methods, ethical considerations and implications of stem cell research.
    Type of Medium: Online Resource
    Pages: X, 374 p. 45 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030553593
    Series Statement: Learning Materials in Biosciences,
    DDC: 660.6
    Language: English
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  • 9
    Keywords: Biotechnology. ; Radiology. ; Biomedical engineering. ; Biotechnology. ; Radiology. ; Biomedical Engineering and Bioengineering. ; Radiology.
    Description / Table of Contents: 1. The Nature and Scope of Research -- 2. Quantitative and Qualitative Approaches to Research-An Overview of Approaches -- 3. Planning Your Research -- 4. The Literature Review -- 5. Quantitative Research Methods -- 6. Qualitative Research Methods -- 7. Data Collection, Analysis and Interpretation -- 8. Communicating Research Findings -- 9. Research Examples in Medical Imaging-A Selected Review.
    Abstract: This book addresses essential principles of research according to the scientific method for medical imaging technology research. The scope of this book covers the nature of scientific research; quantitative and qualitative approaches essentials; research planning; literature review fundamentals; research methods; data collection, analysis, and interpretation; and communicating research findings. The book meets the educational requirements on Research Principles and Concepts (for entry to practice) of the following professional radiologic technology associations: the American Society of Radiologic Technologists (ASRT), the Canadian Association of Medical Radiation Technologists (CAMRT), the College of Radiographers in the United Kingdom, and radiography societies and associations in Asia, Australia, Europe, and Africa. This is an ideal book for radiologic technologists, nuclear medicine technologists, and radiation therapists seeking to get started in research in their profession. Additionally, biomedical imaging engineering technologists, radiologists, and medical imaging physicists may use this as a “guiding principles” textbook.
    Type of Medium: Online Resource
    Pages: XVII, 215 p. 53 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030799564
    DDC: 660.6
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Immunology. ; Biomedical engineering. ; Biotechnology. ; Immunology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: 1. The Musculoskeletal Burden – Where are we now? -- 2. Bacterial Adhesion, Virulence and Biofilm Formation -- 3. Prevention of Infection: Best Practice and Novel Strategies -- 4. Prosthetic Infection: Colonization and Diagnosis -- 5. Soft Tissue Infections -- 6. Incidence, Complications and Novel Treatment Strategies: Diabetic Ulcer of the Limb -- 7. Incidence, Complications and Novel Treatment Strategies: Osteomyelitis -- 8. Incidence, Complications and Novel Treatment Strategies: Joint Arthroplasty -- 9. Incidence, Complications and Novel Treatment Strategies: Massive Bone Tumour Surgery -- 10. Incidence, Complications and Novel Treatment Strategies: Pediatric Spinal Surgery & Management -- 11. War Wounds and Orthopaedic Trauma Devices.
    Abstract: This book gathers international knowledge and contemporary clinical and scientific evidence on infections associated with the musculoskeletal system at a time when we are confronted with significant challenges and uncertainty. A key focus of the book is enhancing and advancing future discovery in the detection, prevention and treatment of musculoskeletal infection. This is an ideal book for physicians, surgeons, research scientists, university students, as well as medical and allied health students.
    Type of Medium: Online Resource
    Pages: VII, 375 p. 41 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030832513
    DDC: 660.6
    Language: English
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  • 11
    Keywords: Biotechnology. ; Neurology . ; Biomedical engineering. ; Biotechnology. ; Neurology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Section A Physiology -- An Overview On Sleep Medicine -- Covering The Gap Between Sleep And Cognition – Mechanisms and Clinical Examples -- Obstructive sleep apnoea: Focus on Pathophysiology -- Diagnosis of obstructive sleep apnea in patients with associated comorbidity -- Pediatric Obstructive Sleep Apnea: What’s in a Name? -- Treatment of Cheyne-Stokes respiration in heart failure with adaptive servo-ventilation: An integrative model -- Section B Diagnostic innovations -- Automated scoring of sleep and associated events -- Conventional machine-learning methods applied to the automatic diagnosis of sleep apnea -- Home Sleep Testing of Sleep Apnea -- ECG and heart rate variability in sleep-related breathing disorders -- Cardiopulmonary Coupling -- Pulse oximetry: the working principle, signal formation, and applications -- Oximetry indices in the management of sleep apnea: from overnight minimum saturation to the novel hypoxemia measures -- Airflow Analysis In The Context OF Sleep Apnea -- Deep-learning Model Based on Convolutional Neural Networks to Classify Apnea-hypopnea Events From The Oximetry Signal -- Tracheal sound analysis -- Obstructive Sleep Apnea with COVID-19 -- Section C Therapeutic innovations -- APAP, BPAP, CPAP and new modes of positive airway pressure therapy -- Adherence monitoring using telemonitoring techniques -- Innovations in The Treatment of Pediatric Obstructive Sleep Apnea -- Hypoglossal Nerve Stimulation Therapy -- Anna M. Mohammadieh -- Index.
    Abstract: The book focuses on biomedical innovations related to the diagnosis and treatment of sleep apnea. The latest diagnostic tools are described, including sleep laboratory equipment, wearables, and even smartphone apps. Innovative medical devices for treatment are also covered, such as CPAP, Auto-PAP, hypoglossal nerve stimulation, phrenic nerve stimulation, acoustic brain stimulation and electrical brain stimulation. This is an ideal book for biomedical engineers, pneumologists, neurologists, cardiologists, physiologists, ENT physicians, pediatrics, and epidemiologists who are interested in learning about the latest technologies in treating and diagnosing sleep apnea. Chapter 12 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XI, 389 p. 68 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031064135
    Series Statement: Advances in Experimental Medicine and Biology, 1384
    DDC: 660.6
    Language: English
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  • 12
    Keywords: Biotechnology. ; Biomedical engineering. ; Biotechnology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: 1.Confocal laser scanning microscopy and fluorescence correlation methods for evaluation of molecular interactions -- 2.Number and Brightness Imaging: visualization of protein oligomerization state in living cell -- 3.Single-molecule analysis on the coupling of molecular state and reaction kinetics -- 4.Imaging lipid rafts in the plasma membrane using novel probe and super-resolution microscopy -- 5.Multiplex Immunohistochemistry (IHC) -- 6.Micro-endoscopy for live small animal fluorescent imaging -- 7.Immuno-gold techniques -- 8.Correlative Light and Electron Microscopy for Nanoparticle-Cell Interaction -- 9.Diagnostic and Therapeutic Nanomedicine -- 10.Semiconductor nanocrystals for biological imaging and fluorescence spectroscopy -- 11.DNA/RNA fluorescence imaging by synthetic nucleic acids -- Section II: Label-free techniques and advanced tomographic imaging -- 12.“Magnetic resonance imaging for preclinical study -- 13.Holotomography techniques for 3D label-free imaging of live cells and tissues -- 14.Dynamic-contrast optical imaging techniques -- 15.Emerging biological and clinical applications of photoacoustic tomography -- Section III: Potential (synergic) biotechnologies to be joined with imaging techniques -- 16.Generation of genetically-engineered mouse models using CRISPR-Cas system -- 17.Highly efficient generation of cell lines stably expressing genes of interest via Cre recombinase mediated knock-in method in mouse embryonic stem (ES) cells and its application for microscopic imaging techniques -- 18.Mass spectrometry based metabolomics in translational research -- 19.Application of mass spectrometry in drug metabolism and pharmacokinetics for drug development -- 20.Discovery and Application of Chemical Probes for Translational Research -- 21.Regeneration of skin cells by mesenchymal stem cell-derived exosomes.
    Abstract: This book is a wide-ranging guide to advanced imaging techniques and related methods with important applications in translational research or convergence science as progress is made toward a new era in integrative healthcare. Conventional and advanced microscopic imaging techniques, including both non-fluorescent (i.e., label-free) and fluorescent methods, have to date provided researchers with specific and quantitative information about molecules, cells, and tissues. Now, however, the different imaging techniques can be correlated with each other and multimodal methods developed to simultaneously obtain diverse and complementary information. In addition, the latest advanced imaging techniques can be integrated with non-imaging techniques such as mass spectroscopic methods, genome editing, organic/inorganic probe synthesis, nanomedicine, and drug discovery. The book will be of high value for researchers in the biological and biomedical sciences or convergence science who need to use these multidisciplinary and integrated techniques or are involved in developing new analytical methods focused on convergence science. .
    Type of Medium: Online Resource
    Pages: VI, 564 p. 191 illus., 161 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813360648
    Series Statement: Advances in Experimental Medicine and Biology, 1310
    DDC: 660.6
    Language: English
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  • 13
    Keywords: Biotechnology. ; Engineering design. ; Biomedical engineering. ; Biotechnology. ; Engineering Design. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: I. FUNDAMENTALS -- 1. The medical industry: Present situation, global health concerns and outlook -- 2. General considerations for engineering open-source medical devices.-3. Systematic assessment of needs and viability analyses.-II. DESIGN METHODS FOR OPEN-SOURCE MEDICAL DEVICES -- 4. Creativity promotion: Collaborative design environments & open-innovation.-5. Safety-guided design methods for open-source medical devices -- 6. Design and simulation of open-source medical devices -- III. MANUFACTURING METHODS FOR OPEN-SOURCE MEDICAL DEVICES -- 7. Prototyping of open-source medical devices -- 8. Manufacturing of personalized open-source medical devices -- 9. Mass-production of open-source medical devices -- IV. MAKING A REAL IMPACT WITH OPEN-SOURCE MEDICAL DEVICES -- 10. Open-source medical device approval and certification -- 11. Marketing open-source medical devices: Managing quality and supply chain -- 12. Issues linked to the long-term sustainability of open-source medical devices.
    Abstract: This book focuses on the challenges and potentials of open source and collaborative design approaches and strategies in the biomedical field. It provides a comprehensive set of good practices and methods for making these safe, innovative and certifiable biomedical devices reach patients and provide successful solutions to healthcare issues. The chapters are sequenced to follow the complete lifecycle of open source medical technologies. The information provided is eminently practical, as it is supported by real cases of study, in which collaboration among medical professionals, engineers and technicians, patients and patient associations, policy makers, regulatory bodies, and citizens has proven beneficial. The book is also supported by an online infrastructure, UBORA, through which open-source medical devices can be collaboratively developed and shared for the democratization of medical technology and for promoting accessible biomedical engineering education.
    Type of Medium: Online Resource
    Pages: VIII, 271 p. 86 illus., 78 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030793630
    DDC: 660.6
    Language: English
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  • 14
    Keywords: Biotechnology. ; Regenerative medicine. ; Medical sciences. ; Biomedical engineering. ; Pharmaceutical chemistry. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Health Sciences. ; Biomedical Engineering and Bioengineering. ; Pharmaceutics.
    Description / Table of Contents: 1. An Introduction to Biomedical Product Development -- 2. Basic Essentials and Applications of Quality Management System (QMS) in Biomedical Sciences -- 3. Principles of Good Laboratory Practice (GLP) -- 4. Design of Experimental Studies in Biomedical Sciences -- 5. Preclinical Studies for Development of Biomedical Products -- 6. Principles of Good Manufacturing Practice (GMP) -- 7.The importance of Cleanroom facility in manufacturing of biomedical products -- 8. Safety concerns and requirement of cell based products for clinical application -- 9. Standards and regulatory frameworks (for cell and tissue based products) -- 10. Principles of Good clinical Practice (GCP) -- 11. Design, performance and monitoring of clinical trials -- 12. Good Clinical Practice: Guidelines and Requirement -- 13. Ethical Considerations of Biomedical Products Development.
    Abstract: This textbook covers all the steps in manufacturing a biomedical product from bench to bedside. It specifically focuses on quality assurance and management and explains the different good practice principles in the various phases of product development as well as how to fulfill them: Good laboratory practice, good manufacturing practice and good clinical practice. It provides readers with the know-how to design biomedical experiments to ensure quality and integrity, to plan and conduct standard preclinical studies and to assure the quality of the final manufactured biomedical products. Importantly, it also addresses ethical concerns and considerations. The book discusses the guidelines and ethical considerations for preclinical and clinical studies, to allow readers to identify safety concerns regarding biomedical products and to improve pre-clinical studies for the development of better products. This textbook is a valuable guide for biomedical students (B.Sc., M.S., and Ph.D. students) in the field of molecular medicine, medical biotechnology, stem cell research and related areas, as well as for professionals such as quality control staff, tissue bankers, policy-makers and health professionals.
    Type of Medium: Online Resource
    Pages: XIV, 157 p. 16 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356262
    Series Statement: Learning Materials in Biosciences,
    DDC: 660.6
    Language: English
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  • 15
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Medicine History. ; Biomedical engineering. ; Biotechnology. ; History of Medicine. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Introduction by Vera L. Talis -- Lecture 1 -- Lecture 2 -- Lecture 3 -- Lecture 4 -- Lecture 5 -- Lecture 6 -- Lecture 7 -- Lecture 8 -- Lecture 9 -- Lecture 10.
    Abstract: This book comprises a series of lectures given by celebrated Soviet neurophysiologist Nikolai Alexandrovich Bernstein in Moscow in 1925 and first published in Russian in 1926. Bernstein’s groundbreaking work, which has had a significant influence on the development of neuroscience, movement studies, and other fields of study in Russia, Eastern Europe, and the West, was suppressed during Stalin’s regime. At the time of its publication, Biomechanics for Instructors was a significant resource for teachers, with its descriptions of the movement of joints and degrees of freedom, illustrations of how to calculate the work capacity of muscles with bones acting as levers, the role of the central nervous system in movement, and more. Though the terminologies and methods have changed and been updated as research and technologies have progressed, the book remains a valuable introduction for those interested in Bernstein’s work more generally, and to those involved in the study of biomechanics. This book is also of interest to historians and philosophers of neuroscience, as well as those involved in movement studies in both the scientific and artistic domains, and to physiotherapists and those involved in sports research and practice.
    Type of Medium: Online Resource
    Pages: XXXIII, 155 p. 86 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030361631
    DDC: 660.6
    Language: English
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  • 16
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Cytology Technique. ; Biomedical engineering. ; Regenerative medicine. ; Biotechnology. ; Cytological Techniques. ; Biomedical Engineering and Bioengineering. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Chapter 1. Introduction to 3D cell culture -- Chapter 2. Lab equipment for 3D cell culture -- Chapter 3. A view from the cellular perspective -- Chapter 4. Biological, natural and synthetic 3D matrices -- Chapter 5. Hydrogels for 3D cell culture -- Chapter 6. Vascularization in 3D cell culture -- Chapter 7. Application of scaffold-free 3D models -- Chapter 8. 10. Microfluidic Systems and Organ (Human) on a Chip -- Chapter 9. 3D-Bioprinting -- Chapter 10. Non-destructive and label-free monitoring of 3D cell constructs.
    Abstract: This textbook shall introduce the students to 3D cell culture approaches and applications. An overview on existing techniques and equipment is provided and insight into various aspects and challenges that researchers need to consider and face during culture of 3D cells is given. The reader will learn the importance of physiological cell, tissue and organ models and gains important knowledge on 3 D analytics. This textbook deepens selected aspects of the textbook “Cell Culture Technology”, which also is published in this series, while offering extended insight into 3D cell culture. The concept of the textbook encompasses various lectures ranging from basics in cell cultivation, tissue engineering, biomaterials and biocompatibility, in vitro test systems and regenerative medicine. The textbook addresses Master- and PhD students interested and/or working in the field of modern cell culture applications and will support the understanding of the essential strategies in 3D cell culture and waken awareness for the potentials and challenges of this application.
    Type of Medium: Online Resource
    Pages: XV, 252 p. 88 illus., 83 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030667498
    Series Statement: Learning Materials in Biosciences,
    DDC: 660.6
    Language: English
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  • 17
    Keywords: Biotechnology. ; Medicine Research. ; Biology Research. ; Biomedical engineering. ; Biotechnology. ; Biomedical Research. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Introduction -- Part 1. History of UPE research -- Mitogenetic rays -- Oxidation, free-radicals and ultraweak luminescence -- Biophotons and the International Institute of Biophysics (IIB) -- Part 2. Physics of light and light research -- Physics of photon emission -- Chemiluminescence as a tool for free radical research -- Highly sensitive imaging and spectral analysis of UPE from biological systems and their application -- Part 3. Molecular mechnisms of UPE -- Free radicals in biology -- Ultraweak luminescence from aqueous systems -- Chemiluminescence in oxidation of hydrocarbons: mechanistic fundamentals -- Chemiluminescence in oxidation of fatty acids and lipids -- Chemiluminescence in protein oxidation -- Emitters of endogenous biological chemiluminescence: quantum chemical modeling insights -- Enzymatic sources of free radicals -- Part 4. UPE research in life science -- Luminescence of animal tissues and vegetable oils -- Ultraweak photon emission from human body in relation to anatomy and histology -- Chronobiological aspects of spontaneous ultra-weak photon emission in humans: Ultradian, circadian and infradian rhythms -- Autoluminescence in seedlings: applications -- Application potentiality of Delayed Luminescence in Medicine, Biology and Food Quality researches -- Part 5. Mitogenetic effect and related phenomena: unresolved problems of UPE -- Mitogenetic effect: preface -- Mitogenetic effect in biological systems -- Physical properties of mitogenetic radiation -- Secondary, degradation and necrobiotic radiation -- Mitogenetic research in medicine: radiation of blood and cancer diagnostics -- Part 6. Non-chemical distant interaction hypothesis - pro et contra -- Non-chemical distant interaction: preface -- The possible functions of electromagnetic cell communication -- Understanding of Fritz-Albert Popp’s biophoton theory from the viewpoint of a biologist -- Limits to the information transfer through UPE -- Quantum nonlocality and biological coherence -- Part 7. Perspectives -- Integrating ultraweak photon emission in mitochondrial research -- Selected biophysical methods for enhancing biological autoluminescence -- Upconverting nanoparticles as sources of singlet oxygen -- Upconverting nanoparticles as sources of singlet oxygen -- Delayed Luminescence as a tool to study the structures of systems of biological interest and their collective long-living excited states -- Index.
    Abstract: This book addresses the phenomenon of biological autoluminescence (also known as ultraweak photon emission, UPE, biochemiluminescence, or biophotons) and deals with a very broad spectrum of subjects, ranging from basic observational studies to molecular mechanisms, free-radical processes, physics of electron excitation and photon emission, as well as detection techniques. The chapter topics include UPE in plants, animals, and the human body; microorganisms and subcellular structures; and model systems, illustrating its high prevalence. Several sections of the book provide some backstory, with emphasis on methodology, unresolved questions, and existing controversies. The authors raise and discuss complex, potentially divisive aspects: Are there any reasons to assume the existence of non-chemical interaction in biological systems? Can research results in the field of mitogenetic radiation, delayed luminescence, and oxychemiluminescence of model systems, be correctly interpreted? What does the future hold for this area of research? Altogether, this publication gives the reader a thorough overview of biological autoluminescence (UPE, biophotonics) research, making it ideal for students and researchers who are new to the area as well as those who are specializing in it.
    Type of Medium: Online Resource
    Pages: XII, 521 p. 345 illus., 198 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031390784
    DDC: 660.6
    Language: English
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