ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

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Therapeutic Applications of Dopamine D3 Receptor Function : New Insight After 30 Years Of Research (2023)

Boileau, Isabelle. [editor.] ; Collo, Ginetta. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Neurosciences. ; Psychiatry. ; Pharmacology. ; Neuroscience. ; Psychiatry.

Beschreibung / Inhaltsverzeichnis: Preface -- A Historic Review of the D3 Dopamine System from D3 Cloning to Clinical Trials in Schizophrenia and Drug Addiction -- Location, Location, Location: The Expression of D3 Dopamine Receptors in the Nervous System -- Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor-Receptor Interaction and Striatal Function -- Involvement of DA D3 Receptor and Mitochondrial Functions in Structural Neuroplasticity of the Emotional Brain Circuits: Possible Role in Depression -- Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target -- Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson’s Disease -- Therapeutic Challenges of Cognitive Dysfunctions in Neuropsychiatric Disorders: Focus on the Dopamine D3 Receptor -- Dopamine D3 Receptor in Stimulant and Opiate Use Disorders -- The Role of D3 Dopamine-Receptors in Nicotine Dependence: A Synthesis of the Pre-Clinical and Clinical Literature -- The Dopamine D3 receptor in Food Addiction -- The Dopamine D3 Receptor Pharmacology and the Therapeutic Use of D3 Receptor Ligands in Schizophrenia -- D3 receptors and Restless Legs Syndrome -- D3 receptors and PET imaging.

Kurzfassung: The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson’s disease, restless legs syndrome, addictions and substance use disorders). The volume is written by leading experts across multidisciplinary areas (imaging, biobehavioral testing and clinical trials, preclinical models / molecular pharmacology) converging on the therapeutic implications / potential of the D3 receptor. The D3 dopamine receptor is a member of the D2-like family of G protein-coupled receptors. It was cloned and characterized almost 25 years ago. A key feature of the D3 dopamine receptor system, which has attracted considerable attention, is its anatomical localization remarkably restricted to the limbic circuitry. This has spurred the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders (or to some features of neuropsychiatric disorders), including but not limited to psychosis, addictions and substance abuse, mood and movement disorders.

Materialart: Online-Ressource

Seiten: VIII, 275 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031230585

Serie: Current Topics in Behavioral Neurosciences, 60

URL: https://doi.org/10.1007/978-3-031-23058-5

DOI: 10.1007/978-3-031-23058-5

DDC: 615

Sprache: Englisch

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Circulating Tumor Cells : Advances in Liquid Biopsy Technologies (2023)

Cote, Richard J. [editor.] ; Lianidou, Evi. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.

Beschreibung / Inhaltsverzeichnis: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.

Kurzfassung: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).

Materialart: Online-Ressource

Seiten: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.

Ausgabe: 2nd ed. 2023.

ISBN: 9783031229039

Serie: Current Cancer Research,

URL: https://doi.org/10.1007/978-3-031-22903-9

DOI: 10.1007/978-3-031-22903-9

DDC: 571.978

Sprache: Englisch

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Data Monitoring Committees (DMCs) : Past, Present, and Future (2023)

Rawat, Nand Kishore. [editor.] ; Kerr, David. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Medical sciences. ; Drug development. ; Medicine Research. ; Biology Research. ; Pharmaceutical chemistry. ; Biometry. ; Toxicology. ; Pharmacology. ; Preclinical Research. ; Biomedical Research. ; Pharmaceutics. ; Biostatistics. ; Medical Toxicology.

Beschreibung / Inhaltsverzeichnis: Introduction-.What is a DMC?-. Is a DMC required?-. Who is On the DMC?-. What are the Legal and Ethical Aspects of DMC?-. How does the DMC work with SDAC and Sponsor and External Groups ? -- What Does a DMC Meeting Look Like -- What data is used for DMC outputs and who programs? -- What is Included in DMC Outputs? -- What does the DMC final DMC outputs look like and how is it delivered? -- What Types of Safety Outputs Does the DMC Receive? -- What types of efficacy outputs does the DMC receive? -- What types of other outputs does the DMC receive? -- What About In-Between DMC Meetings -- What types of formal interim analyses does the DMC review? -- What does the paperwork from meetings look like? -- How does the DMC assess risk-benefit for their decision making? -- What are some examples? -- Conclusions.

Kurzfassung: This book provides an overview of Data Monitoring Committees - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotech/pharma and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to smoothly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the implications of it are so great. This book provides the following: Thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation; Includes practical and hands-on information on DMC implementation; Discusses a wide range of clinical trial – by phase and therapeutic area.

Materialart: Online-Ressource

Seiten: XII, 111 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031287602

URL: https://doi.org/10.1007/978-3-031-28760-2

DOI: 10.1007/978-3-031-28760-2

DDC: 615

Sprache: Englisch

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Synbiotics for the Management of Cancer (2023)

Mishra, Neeraj. [editor.] ; Bhatt, Shvetank. [editor.] ; Paudel, Keshav Raj. [editor.] ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Cancer. ; Cancer Treatment. ; Pharmacology. ; Cancers. ; Cancer Therapy.

Beschreibung / Inhaltsverzeichnis: Chapter 1_Introduction to Cancer -- Chapter 2_Effect of anticancer treatment approches on gut microbiota -- Chapter 3_Synbiotic: A promising approach for the treatment of cancer -- Chapter 4_Correlation between ROS and Synbiotics for effective treatment of cancer -- Chapter 5_Influence of synbiotics on inflammation and immune microenvironment for the treatment of cancer -- Chapter 6_Synbiotics in colorectal cancer -- Chapter 7_Synbiotics in cervical cancer -- Chapter 8_Synbiotics in prostate cancer -- Chapter 9_Synbiotics in gastric cancer -- Chapter 10_Synbiotics in lung cancer -- Chapter 11_Synbiotics in small cell pancretatic cancer -- Chapter 12_Synbiotics in breast cancer -- Chapter 13_Synbiotics in hepatocellular carcinoma -- Chapter 14_Synbiotics in ovarian cancer -- Chapter 15_Regulatory issues of synbiotics in cancer.

Kurzfassung: This book illustrates the significance of probiotics and prebiotics for the management of various types of cancers. The up-to-date chapters provide recent information about the effect of anticancer treatment approaches on gut microbiota, the correlation between ROS and synbiotics for effective cancer treatment, and the influence of synbiotics on inflammation and immune microenvironment for cancer treatment. It also describes the regulatory issues about synbiotics in the management of cancer. This book is an essential resource for scientists working in the field of cancer, pharmaceutical & clinical sciences, and cancer clinicians. This book is also very useful for undergraduate and postgraduate students of Pharmacy and Biotechnology and medical researchers, mainly working in microbiology, immunology, and cancer biology.

Materialart: Online-Ressource

Seiten: XVII, 340 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811975509

URL: https://doi.org/10.1007/978-981-19-7550-9

DOI: 10.1007/978-981-19-7550-9

DDC: 615

Sprache: Englisch

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Cancer Neuroscience (2023)

Amit, Moran. [editor.] ; Scheff, Nicole N. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Neurosciences. ; Immunotherapy. ; Cancer Biology. ; Cancer Therapy. ; Neuroscience. ; Cancer Microenvironment. ; Immunotherapy.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.

Kurzfassung: This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.

Materialart: Online-Ressource

Seiten: XII, 202 p. 21 illus., 20 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031324291

URL: https://doi.org/10.1007/978-3-031-32429-1

DOI: 10.1007/978-3-031-32429-1

DDC: 571.978

Sprache: Englisch

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Recent Advances in Pharmaceutical Innovation and Research (2023)

Singh, Prati Pal. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Pharmaceutical chemistry. ; Drug delivery systems. ; Nanobiotechnology. ; Pharmacology. ; Pharmaceutics. ; Drug Delivery. ; Nanobiotechnology.

Beschreibung / Inhaltsverzeichnis: Part 1. Pharmaceutical Innovation and Research -- Chapter 1. Innovation in stabilization of biopharmaceuticals -- Chapter 2. Concepts in pharmacogenomics: tools and applications -- Chapter 3. Pharmacogenetics–a new approach for the selection of the right drug -- Chapter 4. Meeting the unmet challenges of pharmaceutical research using artificial intelligence -- Chapter 5. Pharmaceutical innovation and research in ayurved -- Chapter 6. Ayurveda intervention in perimenopausal syndrome -- Part 2. Drug Discovery and Development -- Chapter 7. Innovative strategies in drug discovery and pharmacoinformatics -- Chapter 8. Advances in peptide synthesis -- Chapter 9. Peptidomimetics in Medicinal Chemistry: The Art of Transforming Peptides to Drugs -- Chapter 10. Diverse Pharmacological Activities of 4-aminoquinoline and its Derivatives -- Chapter 11. Thiourea catalysts for synthesis of active pharmaceutical ingredients -- Chapter 12. The Chemistry and Pharmacology of Mandarin Orange -- Chapter 13. Recent progress in the pharmacology of phytoestrogens: emerging neuromodulators for treating anxiety and depression -- Chapter 14. Next-generation cell-based therapies to combat metastaticbrain tumor -- Chapter 15. Pharmacokinetics and Pharmacodynamics: Fundamentals and Role(s) in Drug Discovery and Development -- Chapter 16. An update on pharmacokinetic models -- Chapter 17. Pharmacodynamics: Basics and Applications in Drug Research -- Part 3. Drug Delivery and Nanotechnology -- Chapter 18. Technological innovations in pharmaceutical drug nanocrystals -- Chapter 19. Fixed Dose Combinations: Innovations and Research -- Chapter 20. Significance of Intranasal Drug Delivery Systems: Recent Trends and Clinical Investigations in Brain Disorders -- Chapter 21. Current challenges and nanotechnology-based pharmaceutical approaches for the treatment and control of visceral leishmaniasis -- Chapter 22. Polymeric Nanoparticles-based Drug Delivery Systems for Anticancer Therapy. Chapter 23. Carbon nanotubes: a review of toxicity and applicability in biomedical applications -- Chapter 24. Recent trends in topical herbal nanotherapeutics for psoriasis -- Part 4. Pharmaceutical Microbiology -- Chapter 25. Antibiotics: past, present, future, and clinical pipeline -- Chapter 26. Innovative strategies to tackle antimicrobial resistance -- Chapter 27. Molecular and mechanistic insights of yeast flocculation -- Chapter 28. Management of hepatitis virus C: current and future treatments -- Chapter 29. Tuberculosis: experimental models, innovations and challenges -- Chapter 30. Targeting outer membrane to tackle multi-drug resistant bacterial pathogens -- Chapter 31. Diphtheria-A Paradigmatic Vaccine Preventable Toxigenic Disease with Changing Epidemiology -- Chapter 32. Emerging and re-emerging infections: an overview.

Kurzfassung: This book covers several important aspects of pharmaceutical research and innovations. It presents important topics on drug delivery, novel microsponge, nanocrystals, polymeric nanoparticles, peptide synthesis, biopharmaceuticals, pharmacodynamics, yeast flocculation, neuromodulators, innovative drug discovery, pharmacoinformatics, aminoquinoline, thiourea crystals for API synthesis, FDCs and formulations research, ayurveda and natural products, and innovations to militate anti-microbial resistance (AMR). A chapter is devoted to the applications of Artificial Intelligence and Machine Learning in diverse sectors of the pharmaceutical industry, including drug discovery and development, drug repurposing, and improving pharmaceutical productivity. The book also reviews the role of pharmacogenomics and pharmacogenetics in drug development and precision medicine. Further, the book presents an updated summary of recent advances in the fields of nanomedicines and nano-based drug delivery systems. This book is useful to pharmaceutical sciences students, researchers, educators, and professionals in the pharmaceutical industry to understand the intricacies of new drug research and innovations.

Materialart: Online-Ressource

Seiten: XXI, 770 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819923021

URL: https://doi.org/10.1007/978-981-99-2302-1

DOI: 10.1007/978-981-99-2302-1

DDC: 615

Sprache: Englisch

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Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications (2023)

Mishra, Neeraj. [editor.] ; Pandey, Vikas. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Nanobiotechnology. ; Drug delivery systems. ; Pharmacology. ; Nanobiotechnology. ; Drug Delivery.

Beschreibung / Inhaltsverzeichnis: Ch 1 Introduction to block co-polymers -- Ch 2 Role of block co-polymers in drug delivery -- Ch 3 Role of block co-polymers in enhancement of poor solubility of drugs -- Ch 4 Synthesis and Self–assembly of block copolymers -- Ch 5 Role of block co-polymers in treatment of brain disorders -- Ch 6 Role of block co-polymers in treatment of neurodegenerative disorders -- Ch 7 Role of block co-polymers in colon cancer -- Ch 8 Role of block co-polymers in lung cancer -- Ch 9 Role of block co-polymers in IBD -- Ch 10 Role of block co-polymers in vaccine -- Ch 11 Role of block co-polymers in treatment of GIT disorders -- Ch 12 Role of block co-polymers in topical drug delivery -- Ch 13 Role of block co-polymers in targeted drug delivery -- Ch 14 Role of block co-polymers in ocular drug delivery -- Ch 15 Role of block co-polymeric micelles in drug delivery -- Ch 16 Applications of block co-polymers as Stimuli Responsive Copolymers -- Ch 17 Patented block co-polymers for various Therapeutics Applications.

Kurzfassung: This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery. It also reviews the use of block copolymers in drug delivery applications from the development of sustained release products to smart polymeric delivery systems such as stimuli-responsive polymeric systems, for example, thermosensitive, redox-sensitive, photo-sensitive, and enzyme-sensitive. The book further discusses the nano assemblies from amphiphilic block copolymers as nanomedicine platforms for diagnosis and therapy due to their relatively small size, high drug loading capacity, controlled drug release, in vivo stability, and prolonged blood circulation. The chapters also review the various patents and ongoing clinical trials on the applications, covering several important new concepts and findings in the field of block copolymers. The book is aimed at researchers, academicians, and industrial scientists involved in the development of drug-delivery systems based on polymers.

Materialart: Online-Ressource

Seiten: XVII, 429 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819969173

URL: https://doi.org/10.1007/978-981-99-6917-3

DOI: 10.1007/978-981-99-6917-3

DDC: 615

Sprache: Englisch

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Hepatobiliary Cancers: An Interdisciplinary Approach (2023)

Rezaei, Nima. [editor.]

Cham :Springer Nature Switzerland :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Immunotherapy. ; Cancer Genetic aspects. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Tumour Immunology. ; Immunotherapy. ; Cancer Genetics and Genomics. ; Cancer Stem Cells.

Beschreibung / Inhaltsverzeichnis: Interdisciplinary Approach in Hepatobiliary Cancers -- Liver Cancer: Interdisciplinary Approach -- The Immune System in Liver Cancer: From Beginning to Progression -- The Tumor Microenvironment in Hepatocellular Carcinoma -- Metabolic Alterations of Hepatocellular Cancer Stem Cells -- Τhe Role of Senescence in NASH-related HCC -- Regulators of Genetic Risk for the Progression of Non-alcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Reconstruction of Transcriptional Network and Signature-Based Metabolic Profiling -- Tumor Microenvironment and Immunotherapy in Advanced Biliary Tract Cancers -- Fibrosis and Immunotherapy in Hepatocellular Carcinoma -- Liver Cancer and the Curative Potential of Nanomedicine -- Locoregional Therapies for Hepatocellular Carcinoma -- Drug Resistance in Hepatocellular Carcinoma -- Liver Stereotactic Body Radiotherapy.

Kurzfassung: Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.

Materialart: Online-Ressource

Seiten: XI, 365 p. 22 illus., 21 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031445286

Serie: Interdisciplinary Cancer Research, 3

URL: https://doi.org/10.1007/978-3-031-44528-6

DOI: 10.1007/978-3-031-44528-6

DDC: 571.978

Sprache: Englisch

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Gastrointestinal Cancers: An Interdisciplinary Approach (2023)

Rezaei, Nima. [editor.]

Cham :Springer Nature Switzerland :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Oncology. ; Immunotherapy. ; Tumors Immunological aspects. ; Nanomedicine. ; Cancer Biology. ; Cancer Therapy. ; Oncology. ; Immunotherapy. ; Tumour Immunology. ; Cancer Nanotechnology.

Beschreibung / Inhaltsverzeichnis: Interdisciplinary Approach in Gastrointestinal Cancers -- Gastrointestinal Cancers: What Is the Real Board of Microenvironment and the Role of Microbiota-Immunity Axis -- Epithelial-Mesenchymal Transition in Gastrointestinal Cancer: From a Basic to a Clinical Approach -- Metabolomics of Gastrointestinal Cancers -- Deregulation of Immune System in Gastric Cancer Development, How Immune Nutrition Might Restore the Functions of Immune Cells -- Helicobacter pylori Virulence Factors, Pathogenicity, and Gastric Cancer -- Gastric Cancer and Helicobacter pylori -- Role of Neuromodulators in Regulation of the Tumor Microenvironment of Gastric and Colorectal Cancers -- The Role of Tumor Microenvironment in Colon Cancer -- Unraveling the Esophageal Cancer Tumor Microenvironment: Insights and Novel Immunotherapeutic Strategies -- The Interplay Between Immunity and Gut Microbiota in Colon Cancer -- Immunotherapy in Gastrointestinal Cancer Focusing on CAR-T Cell Therapy -- Development of Biocompatible Nanocarriers for the Treatment of Colorectal Cancer -- Challenges of Onco-therapeutics in Early Onset Colorectal Cancer -- Unintentional Weight Loss and Malnutrition After Esophageal Cancer and Treatment -- Current Clinical Landscape of Immunotherapeutic Approaches in Pancreatic Cancer Treatment. The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy. .

Kurzfassung: Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.

Materialart: Online-Ressource

Seiten: XI, 404 p. 22 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031483714

Serie: Interdisciplinary Cancer Research, 4

URL: https://doi.org/10.1007/978-3-031-48371-4

DOI: 10.1007/978-3-031-48371-4

DDC: 571.978

Sprache: Englisch

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Biomedical Applications and Toxicity of Nanomaterials (2023)

Mohanan, P. V. [editor.] ; Kappalli, Sudha. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Nanobiotechnology. ; Nanomedicine. ; Pharmacology. ; Nanobiotechnology. ; Nanomedicine and Nanotoxicology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Macroporous cryogel-based systems for water treatment applications and Safety: nanocomposite-based cryogels and bacteria-based bioreactors -- Chapter 2. One dimensional Semiconducting Nanomaterials: Toxicity and Clinical Applications -- Chapter 3. Prospects of Safe use of Nanomaterials in Biomedicalapplications -- Chapter 4. Hyaluronic acid-based nanotechnologies for delivery and treatment -- Chapter 5. Theranostics nanomaterials for safe cancer treatment -- Chapter 6. Cardiovascular safety assessment of new chemical entities: current perspective and emerging technologies -- Chapter 7. Toxicology of pharmaceutical products during drug development -- Chapter 8. Safety and Risk assessment of food items -- Chapter 9. Non toxic Natural products as regulators of tumour suppressor gene function -- Chapter 10. Advancements in the safety of Plant medicine: Back to nature -- Chapter 11. Chemicals and their interaction in the aquaculture system -- Chapter 12. Zebrafish as a biomedical model to define developmental origins of chemical toxicity -- Chapter 13. Green synthesis of non toxic nanoparticles -- Chapter 14. Synthesis, characterisation and safety of titanium oxide nanoparticles -- Chapter 15. Characterisation of non toxic nanomaterials for biological applications -- Chapter 16. Toxicity assessment of nanoparticle -- Chapter 17. Safety of nanoparticles: emphasis on antimicrobial properties -- Chapter 18. Quantum dots for imaging and its safety -- Chapter 19. Genotoxicity evaluation of nanosized materia -- Chapter 20. Scaffoldmaterials and toxicity -- Chapter 21 Biological Safety and Cellular interactions of nanoparticles -- Chapter 22. Role of artificial intelligence in the toxicity prediction of drugs -- Chapter 23. Chemicals and rodent models for the safety study of alzheimer’s disease -- Chapter 24. Mitochondria-targeted liposomal delivery in Parkinson's disease: safety concerns -- Chapter 25. Routes of Nano-drug Administration and Nano-based drug delivery system and toxicity -- Chapter 26. Green Synthesised silver nanoparticles phytotoxicity and applications in agriculture: An overview -- Chapter 27 status of safety concerns of microplastic detection strategies -- Chapter 28. Impact of insecticides on man and environment.

Kurzfassung: This book covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of information for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.

Materialart: Online-Ressource

Seiten: XVIII, 768 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811978340

URL: https://doi.org/10.1007/978-981-19-7834-0

DOI: 10.1007/978-981-19-7834-0

DDC: 615

Sprache: Englisch

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From PharmD to Industry : A Fellowship Guide (2023)

Langas, Victoria. ; Flood, Victoria.

Cham :Springer Nature Switzerland :

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Schlagwort(e): Pharmacology. ; Pharmacy. ; Career education. ; Pharmacology. ; Pharmacy. ; Career Skills.

Beschreibung / Inhaltsverzeichnis: Fellowship 101 -- The First Professional Year (P1) -- The Second Professional Year (P2) -- The Third Professional Year (P3) -- The Fourth Professional Year (P4) -- Midyear Applications, Interviews, and Receptions -- Transitioning from Student to Fellow -- Navigating the Virtual Landscape.

Kurzfassung: For many Doctor of Pharmacy (PharmD) candidates, post-graduate training is a highly prestigious and sought after experience that can further one’s pre-existing education. Some of these post-graduate training opportunities include but are not limited to pharmacy residencies, pharmaceutical industry fellowships, and PhD/Masters programs. There is a large gap in the current Doctor of Pharmacy curriculum about pharmaceutical industry fellowship programs and potential pharmaceutical industry opportunities. Through the eyes of current industry fellows and professionals, this book serves as a resource to learn more about fellowship opportunities and their respective application processes. In addition, this manual aims to provide a clear and concise roadmap to achieving a career in industry through a fellowship program. Whether you are a current student pharmacist, post-graduate pharmacy trainee (pharmacy resident), or industry professional, this manual addresses the current landscape of industry fellowship programs, an overview of industry opportunities, and a glimpse into what being a fellow entails. Readers of this book can expect to gain: An overview of pharmaceutical industry fellowship programs and opportunities Helpful advice and insight from current fellows and industry professionals A streamlined pathway to navigating the fellowship application process An understanding of the journey from being a student, to achieving a fellowship, to becoming an industry professional This book bridges the gap in education surrounding pharmaceutical industry fellowships and pharmacy careers in industry and increases access to first-hand information and real-world perspectives of current professionals to provide a firm foundation for those interested in pursuing a career in industry or learning more about fellowship programs.

Materialart: Online-Ressource

Seiten: XIX, 92 p. 4 illus., 3 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031357879

Serie: SpringerBriefs in Pharmaceutical Science & Drug Development,

URL: https://doi.org/10.1007/978-3-031-35787-9

DOI: 10.1007/978-3-031-35787-9

DDC: 615

Sprache: Englisch

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Artificial Intelligence and Precision Oncology : Bridging Cancer Research and Clinical Decision Support (2023)

Dlamini, Zodwa. [editor.]

Cham :Springer Nature Switzerland :

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Schlagwort(e): Cancer. ; Oncology. ; Medical screening. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Oncology. ; Cancer Screening. ; Cancer Therapy. ; Tumour Biomarkers.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction: The Application of AI in Precision Oncology: Tailoring Diagnosis, Treatment, and the Monitoring of Disease Progression to the Patient -- Part I. Artificial Intelligence for Screening, Diagnosis, Monitoring in Precision Oncology -- Chapter 2. Application of AI in Novel Biomarkers Detection that Induce Drug Resistance, Enhance Treatment Regimens and Advancing Precision Oncology -- Chapter 3. Use of Artificial Intelligence in Implementing Mainstream Precision Medicine to Improve Traditional Symptom-driven Practice of Medicine: Allowing Early Interventions and Tailoring better-personalized Cancer Treatments -- Chapter 4. AI as a Novel Approach for Exploring ccfNAs in Personalized Clinical Diagnosis and Prognosis: Providing Insight into the Decision-Making in Precision Oncology -- Chapter 5. AI-Enhanced Digital Pathology and Radiogenomics in Precision Oncology -- Part II. Artificial Intelligence and Omics in Precision Oncology -- Chapter 6. Epigenetics Analysis Using Artificial Intelligence in the Era of Precision Oncology -- Chapter 7. Association of Metabolomics with AI in Precision Oncology: Emerging Perspectives for More Effective Cancer Care -- Chapter 8. Artificial Intelligence Application to Microbiomics Data for Improved Clinical Decision Making in Precision Oncology -- Part III. Artificial Intelligence in Cancer Therapy and the Clinical Applications -- Chapter 9. AI and Nanotechnology in Realizing the Goal of Precision Medicine: Tailoring the Best Treatment for Personalized Cancer Treatment -- Chapter 10. Artificial Intelligence-Based Medical Devices Revolution in Cancer Screening: Impact into Clinical Practice -- Chapter 11. Intelligent Drug Design and Use for Cancer Treatment: The Roles of AI and Precision Oncology in Targeting Patient-Specific Splicing Profiles -- Chapter 12. Applying Artificial Intelligence Prediction Tools for Advancing Precision Oncology in Immunotherapy: Future Perspectives in Personalized Care -- Chapter 13. Employing AI-Powered Decision Support Systems in Recommending the Most Effective Therapeutic Approaches for Individual Cancer Patients: Maximizing Therapeutic Efficacy -- Chapter 14. AI-Pathway Companion in Clinical Decision Support: Enabling Personalized and Standardized Care Along Care Pathways in Oncology -- Chapter 15. AI Tools Offering Cancer Clinical Applications for Risk Predictor, Early Detection, Diagnosis, and Accurate Prognosis: Perspectives in Personalised Care -- Chapter 16. Conclusion and Insights into the Future of AI in Precision Oncology.

Kurzfassung: This book highlights the use of artificial intelligence (AI), big data and precision oncology for medical decision making in cancer screening, diagnosis, prognosis and treatment. Precision oncology has long been thought of as ideal for the management and treatment of cancer. This strategy promises to revolutionize the treatment, control, and prevention of cancer by tailoring tests, treatments and predictions to specific individuals or population groups. In order to accomplish these goals, vast amounts of patient or population group specific data needs to be integrated and analysed to be able to identify key patterns or features which can be used to define or characterize the disease or the response to the disease in these individuals. These patterns or features can be as varied as molecular patterns or features in medical images. This level of data analysis and integration can only be achieved through the use of AI. The book is divided into three parts starting with a section on the use of artificial intelligence for screening, diagnosis and monitoring in precision oncology. The second part: Artificial intelligence and Omics in precision oncology, highlights the use of AI and epigenetics, metabolomics, microbiomics in precision oncology. The third part covers artificial intelligence in cancer therapy and its clinical applications. It also highlights the use of AI tools for risk prediction, early detection, diagnosis and accurate prognosis. This book, written by experts in the field from academia and industry, will appeal to cancer researchers, clinical oncologists, pathologists, medical students, academic teaching staff and medical residents interested in cancer research as well as those specialising as clinical oncologists.

Materialart: Online-Ressource

Seiten: XIV, 315 p. 64 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031215063

URL: https://doi.org/10.1007/978-3-031-21506-3

DOI: 10.1007/978-3-031-21506-3

DDC: 571.978

Sprache: Englisch

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Molecular Biology of Human Cancers (2023)

Schulz, Wolfgang A.

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.

Beschreibung / Inhaltsverzeichnis: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.

Kurzfassung: This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.

Materialart: Online-Ressource

Seiten: XXI, 542 p. 229 illus., 221 illus. in color. , online resource.

Ausgabe: 2nd ed. 2023.

ISBN: 9783031162862

URL: https://doi.org/10.1007/978-3-031-16286-2

DOI: 10.1007/978-3-031-16286-2

DDC: 571.978

Sprache: Englisch

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Metabolomics and Its Impact on Health and Diseases (2023)

Ghini, Veronica. [editor.] ; Stringer, Kathleen A. [editor.] ; Luchinat, Claudio. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Biochemical markers. ; Cytology. ; Analytical biochemistry. ; Pharmacology. ; Biomarkers. ; Cell Biology. ; Analytical Biochemistry.

Beschreibung / Inhaltsverzeichnis: Preface -- Practical Aspects of NMR-Based Metabolomics -- Compound Identification in Mass Spectrometry-Based Metabolomics -- METABOLOMICS USING NMR – Avoiding the ‘Black-Box’ -- Natural products drug discovery: on silica or in silico?- Quantitative NMR Methods in Metabolomics -- Advancements in pulsed stable isotope resolved metabolomics -- Metabolomics in Cell Biology -- NMR-based metabolomics to evaluate individual response to treatments -- Pharmacometabolomics of Asthma as a road map to Precision Medicine -- Prospective metabolomic studies in precision medicine -- Chemotherapy-induced Peripheral Neuropathy -- Metabolomics of Respiratory Diseases.

Kurzfassung: This volume of the Handbook of Experimental Pharmacology, which celebrated its 100th anniversary in 2019, addresses the rapidly growing and evolving field of metabolomics. It has been compiled and designed to broaden and enrich your understanding as well as simplify a complicated picture of the diverse field of metabolomics. This is accomplished by chapters from experts in the field on basic principles as well as reviews and updates of analytical techniques. The variety and different perspectives of the NMR approaches are described in the chapters By David Wishart, Daniel Raftery and Ryan McKay, while mass spectrometry advances are covered by Charles R. Evans and Stefan Kempa. This book also reflects the state of the art in the application of metabolomics to cell biology (Marta Cascante and Ulrich Guenther) and chapters that share insights into the application of metabolomics in various diseases (Paola Turano and Claudio Luchinat, Rachel S. Kelly and Jessica Lasky-Su, Paige Lacy, and Angela Rogers. Relationships of metabolomics with drugs are highlighted by Robert Verpoorte (natural products drug discovery), by Oscar Millet and by Turano and Luchinat (perspectives in precision medicine) and by Daniel L. Hertz (drug-induced peripheral neuropathy). From the above list of diverse topics, we believe this book has interdisciplinary appeal and scholars with an interest in the role of metabolomics in achieving precision medicine will find it of particular or special interest.

Materialart: Online-Ressource

Seiten: VIII, 384 p. 100 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031268595

Serie: Handbook of Experimental Pharmacology, 277

URL: https://doi.org/10.1007/978-3-031-26859-5

DOI: 10.1007/978-3-031-26859-5

DDC: 615

Sprache: Englisch

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Therapeutic potential of Cell Cycle Kinases in Breast Cancer (2023)

Mir, Manzoor. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancers. ; Cancer Therapy. ; Cancer Genetics and Genomics.

Beschreibung / Inhaltsverzeichnis: Chapter 1 An introduction to breast cancer -- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators -- Chapter 4 Cell cycle and cancer -- Chapter 5 cell cycle dysregulation in breast cancer -- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation -- Chapter 7 Breast tumor micro environment and CDks -- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis -- Chapter 9 CDK1 Dysregulation in Breast Cancer -- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers -- Chapter 11 Therapeutic implications of CDKs in Breast Cancer -- Chapter 12 Novel CDK Inhibitors in Breast Cancer -- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach -- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer -- Chapter 15 CDk inhibitor for treatment of breast cancer -- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer -- Chapter 17 Different cyclins and their significance in Breast cancer.

Kurzfassung: This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.

Materialart: Online-Ressource

Seiten: XVII, 373 p. 133 illus., 92 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811989117

URL: https://doi.org/10.1007/978-981-19-8911-7

DOI: 10.1007/978-981-19-8911-7

DDC: 571.978

Sprache: Englisch

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Immunity Boosting Medicinal Plants of the Western Himalayas (2023)

Sharma, Ajay. [editor.] ; Nayik, Gulzar Ahmad. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Natural products. ; Botany. ; Ethnology. ; Pharmacology. ; Natural Products. ; Plant Science. ; Ethnography.

Beschreibung / Inhaltsverzeichnis: 1. Introduction to Western Himalayas -- 2. Achillea millefolium L., Common Yarrow -- 3. Arisaema jacquemontii Blume, Jacquemont's Cobra Lily -- 4. Species of Arnebia genus found in the western Himalayas -- 5. Species of the Berberis genus found in the western Himalayas -- 6. Dactylorhiza hatagirea (D.Don) Soo – Himalayan Marsh Orchid -- 7. Fritillaria roylei Hook.f.: Himalayan Fritillary -- 8. Gentiana kurroo Royle: Himalayan Gentian -- 9. Habenaria intermedia D.Don and Habenaria edgeworthii Hook., f. ex Collett.: The Western Himalayan medicinal Plants -- 10. Humulus lupulus L.: Beer plant -- 11. Inula racemosa Hook. f. – Puskarmool: Its ethnobotanical uses, phytochemicals and pharmacological activities -- 12. Juniperus recurva Buch.-Ham. ex D.Don and Juniperus squamata D. Don: Himalayan Juniper -- 13. Lancea tibetica Hook.f. & Thomson: Ethnobotany, phytochemistry and pharmacology -- 14. Malaxis muscifera (Lindley) O. Kuntze. and Malaxis acuminata D. Don.: Jeevak -- 15. Picrorhiza kurroa Royle ex Benth.: Kutki -- 16. Species of the genus Polygonatum found in the Western Himalayas -- 17. Species of the genus Rhodiola found in the Western Himalayas -- 18. Saussurea lappa C.B. Clarke: Kushta/Kut -- 19. Saussurea lappa C.B. Clarke: Kushta/Kut -- 20. Species of the genus Selinum found in the western Himalayas -- 21. Swertia chirayita (Roxb. ex Flem.): Chirayata/Chiretta -- 22. Taxus wallichiana Zucc.: The Himalayan yew -- 23. Tribulus terrestris L.: Gokshur /Gokharu -- 24. Species the Genus Viola found in Western Himalayas.

Kurzfassung: This book presents a comprehensive guide to traditional immunity-boosting medicinal plants of the Himalayas, their traditional uses, phytochemistry, pharmacology, diversity, conversation, biotechnology, toxicology, as well as future prospective. All the chapters cover the latest advances in ethnobotany, phytochemistry, biochemistry, and biotechnology. The book offers a valuable asset for researchers and graduate students of chemistry, botany, biotechnology, microbiology, and the pharmaceutical sciences. The main purpose of the present book is to draw on the rich culture, folklore, and biodiversity of immunity-boosting medicinal plants of the Western Himalayas, with particular emphasis on the Indian Trans-Himalayan and Western Himalayan region. All the plants included in the present book are extensively used by the local tribes and people for their health-promoting properties from ancient times. This book will be a substantial contribution to the knowledge of the region and the country. Also, the book will be very useful to scientists, graduates, and undergraduates, along with researchers in the fields of natural products, herbal medicines, ethnobotany, pharmacology, chemistry, and biology. Further, it is an equally significant resource for a person working in different traditional medicinal systems; doctors (especially those engaged in Ayurveda, Chinese traditional medicinal system, Amchi, and allopathy); the pharmaceutical industry (for drug design and synthesis); biochemistry and biotechnology sciences; and the agricultural sciences. .

Materialart: Online-Ressource

Seiten: XIX, 609 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811995019

URL: https://doi.org/10.1007/978-981-19-9501-9

DOI: 10.1007/978-981-19-9501-9

DDC: 615

Sprache: Englisch

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Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease (2023)

Striessnig, Jörg. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Medical genetics. ; Human physiology. ; Pharmacology. ; Medical Genetics. ; Human Physiology.

Beschreibung / Inhaltsverzeichnis: Preface -- Part 1 Modulation -- Cav1.1Calcium Channel Signaling Complexes in Excitation–Contraction Coupling: Insights from Channelopathies -- Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia -- Sympathetic Nervous System Regulation of Cardiac Calcium Channels -- Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19 -- Part 2 Pharmacological Approaches -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits -- Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors -- Part 3 Disease insight from channelopathies: consequences for pharmacology and therapeutic strategies -- CACNA1C-Related Channelopathies -- CACNA1D-Related Channelopathies: From Hypertension to Autism -- CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options -- CaV3.2 (CACNA1H) in Primary Aldosteronism,- CaV3.3 Channelopathies -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits.

Kurzfassung: The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.

Materialart: Online-Ressource

Seiten: XII, 316 p. 100 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031384370

Serie: Handbook of Experimental Pharmacology, 279

URL: https://doi.org/10.1007/978-3-031-38437-0

DOI: 10.1007/978-3-031-38437-0

DDC: 615

Sprache: Englisch

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Oncology: Genomics, Precision Medicine and Therapeutic Targets (2023)

Tuli, Hardeep Singh. [editor.] ; Yerer Aycan, Mükerrem Betül. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Cancer Genetic aspects. ; Oncology. ; Therapeutics. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Oncology. ; Therapeutics.

Beschreibung / Inhaltsverzeichnis: Chapter 1 Evolution of translational cancer therapeutics -- Chapter 2 Oncology: Way forward from clinical and molecular diagnosis to treatment -- Chapter 3 Oncogenic genomics alterations in cancer patient -- Chapter 4 Altered mRNA expression profiles in cancer patients -- Chapter 5 microRNAs and long non-coding RNAs as key targets -- Chapter 6 Oncogenic alterations translated into diagnostics -- Chapter 7 Precision medicine in oncology -- Chapter 8 Precision medicine – translation of individualistic treatment in oncology -- Chapter 9Pharmacogenetics and Pharmacogenomics in Precision Medicine -- Chapter 10 Pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines -- Chapter 11 Biomarkers in Precision Medicine in oncology -- Chapter 12 Bioinformatics and biostatistics in Precision Medicine -- Chapter 13 Omics in Precision medicine -- Chapter 14 Translational therapeutic targets : from bench to clinical trials -- Chapter 15 Strength of integartive genomic alterations, precision medicine and therapeutic targets as treatment choice in patient care.

Kurzfassung: This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.

Materialart: Online-Ressource

Seiten: XVI, 274 p. 23 illus., 15 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819915293

URL: https://doi.org/10.1007/978-981-99-1529-3

DOI: 10.1007/978-981-99-1529-3

DDC: 571.978

Sprache: Englisch

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Cancer Research: An Interdisciplinary Approach (2023)

Rezaei, Nima. [editor.]

Cham :Springer Nature Switzerland :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Stem cells. ; Cytology. ; Medical genetics. ; Immunology. ; Cancer Biology. ; Cancer Therapy. ; Cancer Stem Cells. ; Cell Biology. ; Medical Genetics. ; Immunology.

Beschreibung / Inhaltsverzeichnis: Interdisciplinary Approaches in Cancer Research -- Role of Immune Cells in the Tumor Microenvironment -- Spatial Transcriptomic Approaches for Understanding the Tumor Microenvironment (TME) -- Role of Mesenchymal Stem/Stromal Cells in Cancer Development -- Cancer-associated Fibroblasts and Their Role in Cancer Progression -- The Role of Tumoroids in Cancer Research -- Myokines Expression in Cancer Cachexia -- Epigenetics in Cancer Biology -- Epigenetic Regulation of Cancer by Natural Touch: Phytochemicals and Epigenetic Regulation -- Telomerase Reverse Transcriptase in Humans: From Biology to Cancer Immunity -- Molecular Mechanisms of Metal-induced Carcinogenesis -- Epi-drugs Targeting RNA Dynamics in Cancer -- Oncologic Emergencies: Pathophysiology, Diagnosis, and Initial Management -- Malignancies in Inborn Errors of Immunity -- Hematopoietic Stem Cell Transplantation in Patients with Inborn Errors of Immunity and Malignancy -- Personalized Immuno-oncology with Immunodeficiency Mouse Models -- Allergy and Cancer: New Perspectives -- Depression and Cancer: the Inflammatory Bridge -- Impact of Cancer-Related Sarcopenia on Systemic Immune Status -- Surveillance of Subclinical Cardiovascular Complications in Childhood Cancer Survivors: Exercise as a Diagnostic and Therapeutic Modality.

Kurzfassung: Cancer is a major public health concern and one of the leading causes of death. There is no simple solution for this complex disease, therefore interdisciplinary approaches might help to find solutions to many unanswered questions and challenges about cancer. The rapid flow of interdisciplinary research in cancer during recent years has increased our understanding of the nature of cancers. Such interdisciplinary approaches could be helpful for both the diagnosis and the development of more effective therapeutic strategies. The “Interdisciplinary Cancer Research” series publishes comprehensive volumes on different cancers and presents the most updated and peer-reviewed articles on human cancers. Over the past decade, increased cancer research has greatly improved our understanding of the nature of cancerous cells which has led to the development of more effective therapeutic strategies to treat cancers. This interdisciplinary series is of special value to researchers and practitioners working on cell biology, immunology, hematology, biochemistry, genetics, oncology and related fields. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN).

Materialart: Online-Ressource

Seiten: XI, 611 p. 31 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031324581

Serie: Interdisciplinary Cancer Research, 1

URL: https://doi.org/10.1007/978-3-031-32458-1

DOI: 10.1007/978-3-031-32458-1

DDC: 571.978

Sprache: Englisch

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Ethnopharmacology and Drug Discovery for COVID-19: Anti-SARS-CoV-2 Agents from Herbal Medicines and Natural Products (2023)

Chen, Jen-Tsung. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Natural products. ; Nanobiotechnology. ; Bioinformatics. ; Diseases Causes and theories of causation. ; Molecular biology. ; Pharmacology. ; Natural Products. ; Nanobiotechnology. ; Bioinformatics. ; Pathogenesis. ; Molecular Biology.

Beschreibung / Inhaltsverzeichnis: 1. COVID-19: An overview of virology, mutations, pathology, epidemiology, diagnosis, preventions and treatments -- 2. The recent development of therapeutic strategies against COVID-19 -- 3. Plant immunoenhancers: Promising ethnopharmacological candidates for anti-SARS-CoV-2 activity -- 4. Herbal formulations in fighting against the SARS-CoV-2 infection -- 5. Rejuvenation of traditional medicine in the 21st century against SARS-CoV-2 -- 6. Traditional herbal medicines and their active constituents in combating SARS-CoV-2 infection -- 7. Antiviral phytocompounds against animal-to-human transmittable SARS-CoV-2 -- 8. Plants-derived bioactive compounds as potential ACE-2 inhibitors against SARS-CoV-2 infection -- 9. Insights into in silico methods to explore plant bioactive substances in combating SARS-CoV-2 -- 10. Dietary plants, spices and fruits in curbing SARS-CoV-2 virulence -- 11. Therapeutic potential of selected medicinal plants for neurological disorders after the infection of COVID-19 -- 12. Glycyrrhizae Radix et Rhizoma (Gan Cao) for the management of COVID-19 -- 13. COVID-19-induced kidney disease: Ethnopharmacological intervention to ameliorate kidney damage and improve kidney function -- 14. Phytochemicals and nutraceuticals targeting SARS-CoV-2: An in silico analysis -- 15. Therapeutic and prophylactic effects of plant derivatives against SARS-CoV-2 -- 16. Therapeutic potential of essential oils against SARS-CoV-2 infection -- 17. Antiviral properties of South Indian plants against SARS-CoV-2 -- 18. Immune-boosting plants used in Turkish folk medicine and their potential against COVID-19 -- 19. A comparison study of medicinal plants used against SARS-CoV-2 and those recommended against malaria in Africa -- 20. Exploring the potential antiviral properties of Nigella sativa L. against SARS-CoV-2: Mechanisms and prospects -- .

Kurzfassung: This book presents a complete overview of COVID-19 and provides a series of in-depth analyses of the literature and a comprehensive discussion and perspectives on promising anti-SARS-CoV-2 agents based on the system of ethnopharmacology, which covers Chinese medicine, traditional medicines of India and Africa, Turkish folk medicine, essential oils, and some well-known medicinal plants. In this book, the current status of therapeutic strategies against COVID-19 was summarized and a perspective of potential options for the future was proposed. Based on ethnopharmacology, some well-established traditional herbal formulations and bioactive compounds with anti-virus activity were repurposed for managing COVID-19 and post-illness, including neurological disorders and kidney illness. Using drug discovery tools, promising immune enhancers were explored from phytochemicals against SARS-CoV-2. Nutraceuticals from dietary plants, spices, and fruits with anti-virus and antioxidant activities were recommended to prevent infection or severe illness caused by emerging variants. With the aid of systems pharmacology, researchers have gained insights into possible molecular mechanisms of anti-SARS-CoV-2 activity and have predicted a range of candidate compounds from medicinal plants to combat COVID-19. This book explores the current knowledge of drug discovery and ethnopharmacology for managing coronavirus diseases. The content proved the anti-SARS-CoV-2 activity from natural products and traditional herbal medicines. It contributes to the management of global public health and fits the goal of establishing “Good Health and Well-Being,” which is one of “The Sustainable Development Goals (SDGs) 2030".

Materialart: Online-Ressource

Seiten: IX, 590 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819936649

URL: https://doi.org/10.1007/978-981-99-3664-9

DOI: 10.1007/978-981-99-3664-9

DDC: 615

Sprache: Englisch

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Sex and Gender Effects in Pharmacology (2023)

Tsirka, Stella E. [editor.] ; Acosta-Martinez, Maricedes. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Immunology. ; Neurology . ; Endocrinology. ; Cardiology. ; Pharmacology. ; Immunology. ; Neurology. ; Endocrinology. ; Cardiology.

Beschreibung / Inhaltsverzeichnis: Part 1 Pharmacological Basic Principles -- The impact of sex and gender in medicine and pharmacology -- Sex differences in pharmacokinetics -- Clinical pharmacological considerations in transgender medicine -- Sex and gender differences in the pharmacology of the overactive urinary bladder -- Part 2 Pathologies of the Brain -- Sex differences in the evaluation and treatment of stroke -- Sex differences in pain and its treatment -- Therapeutics For Substance-Using Women: The Need To Elucidate Sex-Specific Targets For Better-Tailored Treatments -- Intersection of sex and depression: pathogenesis, presentation and treatments -- Biological and clinical implications of sex-specific differences in Alzheimer’s disease -- Part 3 Diabetes, metabolic diseases & cardiovascular risk -- Gender Differences In Cardiovascular Health: Hormonal Effects on Cardiovscular Risk And Management. - Sex Differences in Glucose Homeostasis -- Sex-gender-based differences in metabolic diseases -- Hypothalamic pituitary gonadal axis disorders impacting fertility in both sexes and the potential of kisspeptin-based therapies to treat them.

Kurzfassung: Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.

Materialart: Online-Ressource

Seiten: VIII, 288 p. 100 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031426483

Serie: Handbook of Experimental Pharmacology, 282

URL: https://doi.org/10.1007/978-3-031-42648-3

DOI: 10.1007/978-3-031-42648-3

DDC: 615

Sprache: Englisch

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The African Marine Litter Outlook (2023)

Maes, Thomas. [editor.] ; Preston-Whyte, Fiona. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pollution. ; Refuse and refuse disposal. ; Water. ; Hydrology. ; Africa Economic conditions. ; Oceanography. ; Sustainability. ; Pollution. ; Waste Management/Waste Technology. ; Water. ; African Economics. ; Ocean Sciences. ; Sustainability.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction to Marine Litter in Africa -- Chapter 2. Marine litter sources and distribution pathways -- Chapter 3. Impacts and Threats of Marine Litter to Africa Chapter -- Chapter 4. Legal and Policy Frameworks to address marine litter through improved livelihoods -- Chapter 5. The way forward, building upon-the-ground innovation.

Kurzfassung: This open access book provides a cross-sectoral, multi-scale assessment of marine litter in Africa with a focus on plastics. From distribution, to impacts on environmental and human health, this book looks at what is known scientifically. It includes a policy analysis of the instruments that currently exist, and what is needed to help Africa tackle marine litter—including local and transboundary sources. Across 5 chapters, experts from Africa and beyond have put together a summary of the scientific knowledge currently known about marine litter in Africa. The context of the African continent and future projections form a backdrop on which the scientific knowledge is built. This scientific knowledge incorporates quantities, distributions, and pathways of litter into the marine environment, highlighting where the impacts of marine litter are most felt in Africa. These impacts have widespread effects, with ecological, social, economic, and human health repercussions. While containing detailed scientific information, this book provides a sound knowledge base for policymakers, NGOs and the broader public.

Materialart: Online-Ressource

Seiten: XXII, 224 p. 33 illus., 29 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031086267

URL: https://doi.org/10.1007/978-3-031-08626-7

DOI: 10.1007/978-3-031-08626-7

DDC: 363.73

Sprache: Englisch

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Agricultural Implications of Fukushima Nuclear Accident (IV) : After 10 Years (2023)

Nakanishi, Tomoko M. [editor.] ; Tanoi, Keitaro. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Agriculture. ; Radiation dosimetry. ; Forestry. ; Physiology. ; Environmental monitoring. ; Pollution. ; Agriculture. ; Radiation Dosimetry and Protection . ; Forestry. ; Animal Physiology. ; Environmental Monitoring.

Beschreibung / Inhaltsverzeichnis: 1. An Overview of our research -- 2. Recovery of Food Production from Radioactive Contamination Caused by the Fukushima Nuclear Accident -- 3. Annual Reduction of Transfer Factors of Radiocesium from Soil to Rice Cultivated in a KCl Fertilized and Straw Plowed-in Paddy Field from 2015 to 2021 -- 4. Effects of radiocesium from suspended matter and fallout on agricultural products -- 5. Verification of Uptake and Transport Properties of Cesium in Hydroponically Cultivated Quercus Serrata -- 6. Candidates for breeding target genes related to cesium transport in plants after the Fukushima Daiichi Nuclear Power Plant accident -- 7. Evaluation of the Absorption of Different Forms of Cesium from Soil -- 8. Structure, Composition, and Physicochemical Properties of Radiocesium-Bearing Microparticles Emitted by the Fukushima Daiichi Nuclear Power Plant Accident -- 9. Verification of Effects on Crops and Surrounding Environment in Agriculture Using Radioactively Contaminated Grass Silage Compost Made by Aerobic Ultra-High Temperature Fermentation -- 10. Transport of 137Cs into Fruits after External Deposition onto Japanese Persimmon Trees -- 11. Progress Towards Managing Radiocesium Contamination in Orchards -- 12. Overview of Radiocesium Dynamics in Forests: First Decade and Future Perspectives -- 13. Toward the Estimation of Radiocesium Activity Concentration in Trunks of Coppiced Quercus Serrata: Leaf Availability Instead of Felling -- 14. Decomposition of Organic Matters in a Forest Floor Enhanced Downward Migration of Radioactive Cs after the Accident of the FDNPP -- 15. Effect of exchangeable and non-exchangeable potassium in soil on cesium uptake by Quercus serrata seedlings -- 16. Ten-year Transition of Radiocesium Contamination in Wild Mushrooms in the University of Tokyo Forests after the Fukushima Accident -- 17. Challenge to resume production of mushroom bed logs by potassium fertilizer application -- 18. Studies on the revitalization of radioactive-contaminated mushroom log forests: focus on shoots -- 19. Contribution of cesium-bearing microparticles to cesium in soil and river water of the Takase River watershed and their effect on the distribution coefficient -- 20. Global Fallout: Radioactive Materials from Atmospheric Nuclear Tests That Fell Half a Century Ago and Where to Find Them -- 21. Resilience Education Program in Iitate Village for the Young Generation.

Kurzfassung: This open access book presents the findings from on-site research into radioactive cesium contamination in various agricultural systems affected by the Fukushima Daiichi Nuclear Power Plant accident in March 2011. This fourth volume in the series reports on studies undertaken at contaminated sites such as farmland and forests, focusing on soil, water, mountain, agricultural products, and animals. It also provides additional data collected in the subsequent years to show how the radioactivity levels in agricultural products and their growing environments have changed with time and the route by which radioactive materials entered agricultural products as well as their movement between different components (e.g., soil, water, and trees) within an environmental system (e.g., forests). The book covers various topics, including radioactivity testing of food products; decontamination trials for rice and livestock production; the state of contamination in, trees, mushrooms, and timber; the dynamics of radioactivity distribution in paddy fields and upland forests; damage incurred by the forestry and fishery industries; and the change in consumers’ attitudes. In the series of this book, a real-time radioisotope imaging system has been introduced, a pioneering technique to visualize the movement of cesium in soil and in plants. This is the only book to provide systematic data on the actual change of radioactivity, which is of great value to all researchers who wish to understand the effect of radioactive fallout on agriculture. In addition, it helps the general public better understand radio-contamination issues in the environment. The project is ongoing; the research groups from the Graduate School of Agricultural and Life Sciences of The University of Tokyo continue their work in the field further to evaluate the long-term effects of the Fukushima accident.

Materialart: Online-Ressource

Seiten: XIII, 276 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811993619

URL: https://doi.org/10.1007/978-981-19-9361-9

DOI: 10.1007/978-981-19-9361-9

DDC: 363.73

Sprache: Englisch

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Human Health Risk Assessment of Toxic Chemical Pollutants in Stormwater : Implications for Urban Stormwater Reuse (2023)

Ma, Yukun. ; Egodawatta, Prasanna. ; McGree, James. ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Water. ; Hydrology. ; Environmental protection. ; Civil engineering. ; Pollution. ; Water. ; Soil and Water Protection.

Beschreibung / Inhaltsverzeichnis: Background -- Research design -- Linking traffic and land use to stormwater quality -- Human health risk assessment from toxic chemical pollutants in stormwater -- Implications for stormwater management and recommendations for future research.

Kurzfassung: This book presents a detailed analysis in relation to human health risk assessment of the main toxic chemical pollutants in urban stormwater generated from urban traffic and land use activities. The knowledge presented in this book was derived based on comprehensive experimental investigations including field sampling, laboratory testing, mathematical modelling, spatial analysis and multivariate and univariate statistical data analyses. The key highlights of the book include the quantitative assessment of the human health risk posed by key toxic chemical pollutants in urban stormwater and the development of linkages between risk and traffic and land use. Additionally, a suite of mathematical equations are presented to predict human health risk based on traffic and land use characteristics through mathematical modelling. These outcomes can significantly assist in effective stormwater risk management under changing traffic and land use in the urban environment. The knowledge presented is of particular interest to readers such as stormwater treatment design specialists, decision-makers and urban planners since these outcomes provide practical suggestions and recommendations for effective urban stormwater treatment design.

Materialart: Online-Ressource

Seiten: VIII, 86 p. 58 illus., 49 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811996160

Serie: SpringerBriefs in Water Science and Technology,

URL: https://doi.org/10.1007/978-981-19-9616-0

DOI: 10.1007/978-981-19-9616-0

DDC: 363.73

Sprache: Englisch

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Persistent Pollutants in Water and Advanced Treatment Technology (2023)

Sinha, Alok. [editor.] ; Singh, Swatantra P. [editor.] ; Gupta, A. B. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Environmental protection. ; Civil engineering. ; Environmental engineering. ; Pollution. ; Soil and Water Protection. ; Environmental Civil Engineering.

Beschreibung / Inhaltsverzeichnis: Impact of Persistent Pollutants on Water Quality -- Marine microplastics: abundance, ecotoxic consequences of associated anthropogenic contaminants and interactions with microorganisms -- World profile of foreseeable strategies for the removal of per- and polyfluoroalkyl substances (PFASs) from water -- Plasticizers, plastic monomers, and their transformation products in environmental waters and wastewater -- Occurrence and Removal of phthalates from aqueous medium using bismuth tungstate-based photocatalysts -- Application of electrochemical technologies for the efficacious removal of persistent organic pollutants from wastewater -- Recent progress in Electrochemical/Electro-oxidation technology: its applicability in highly efficient treatment of persistent organic pollutants specially from coal processed wastewater.

Kurzfassung: This contributed volume discusses the current status of the occurrences, fate and transport of persistent pollutants in water and wastewater. This contents compile the state-of-the-art of emerging technologies such as nanotechnology, advanced oxidation process, membrane processes, sorption, etc. for the clean-up of persistent pollutants in water including heavy metals, pharmaceuticals, phenolic compounds as well as microplastics and their by-products. This volume will be useful as a guide for the researchers to build strategies to deal with persistent pollutant. It also discusses the principal aspects of degradation mechanism of the pollutants, toxic by-products and effectiveness of the emerging technologies. This volume will be a useful guide for those working in soil and water protection, and environmental civil engineering. .

Materialart: Online-Ressource

Seiten: XVII, 477 p. 136 illus., 95 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819920624

Serie: Energy, Environment, and Sustainability,

URL: https://doi.org/10.1007/978-981-99-2062-4

DOI: 10.1007/978-981-99-2062-4

DDC: 363.73

Sprache: Englisch

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Remediation of Chromium-Contaminated Soil: Theory and Practice (2023)

Yang, Weichun. ; Chai, Liyuan. ; Yang, Zhihui. ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Environmental chemistry. ; Environmental monitoring. ; Pollution. ; Environmental Chemistry. ; Environmental Monitoring.

Beschreibung / Inhaltsverzeichnis: Contamination characteristics of soils and biological and chemical behavior of chromium in soil.-Mechanisms of Cr(VI) reduction by microorganisms -- Microbial remediation of chromium-contaminated soil -- Mechanism of chemical reduction of Cr(VI) -- Chemical remediation of chromium-contaminated soil -- Case of chrome-contaminated site remediation project.

Kurzfassung: In accordance with the global needs of heavy metal-contaminated site remediation, this book systematically introduces the latest theories and technical achievements of microbial and chemical treatment for the chromium pollution in the chromium slag and chromium-contaminated soil, combined with the author's research achievements over the decades. The book focuses on the biological and chemical behavior of chromium in soil, microbial, and chemical remediation for the chromium-contaminated soil and the cases of chromium-contaminated site remediation project. This book is used by the scientific researchers and engineering technicians engaged in chromium chemical industry and environmental protection. It is also used as a textbook and reference book for graduate students in environmental science and engineering, soil science, chemistry and chemical engineering, and other related fields.

Materialart: Online-Ressource

Seiten: XI, 303 p. 190 illus., 142 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819954636

Serie: Environmental Science and Engineering,

URL: https://doi.org/10.1007/978-981-99-5463-6

DOI: 10.1007/978-981-99-5463-6

DDC: 363.73

Sprache: Englisch

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Green Nanoremediation : Sustainable Management of Environmental Pollution (2023)

Policarpo Tonelli, Fernanda Maria. [editor.] ; Roy, Arpita. [editor.] ; Ananda Murthy, H C. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pollution. ; Green chemistry. ; Environmental chemistry. ; Pollution. ; Green Chemistry. ; Environmental Chemistry.

Beschreibung / Inhaltsverzeichnis: Chapter. 1. Important Features of Nanomaterials for Environmental Remediation -- Part. I: Green nanoremediation: generating eco-friendly nanoremediators -- Chapter. 2. Green-synthesis of nanomaterials for environmental remediation -- Chapter. 3. Nanoremediation: main strategies, advantages and disadvantages - Strategic methods of nanoremediation through nanomaterials synthesized from microbes -- Chapter. 4. Fungi-based synthesis to generate nanomaterials to nanoremediation -- Chapter. 5. Algae-based synthesis to generate nanomaterials to nanoremediation -- Chapter. 6. Plant-based synthesis to generate nanomaterials to nanoremediation -- Chapter. 7. Innovations on the synthesis of metal nanoparticles to nanoremediation -- Part II: Important green nanomaterials in the management of environmental pollution -- Chapter. 8. Main green nanomaterials to water remediation -- Chapter. 9. Green non-carbon-based nanomaterials to environs remediation -- Chapter. 10. Green Iron nanoparticles for nanoremediation -- Chapter. 11. Green Silver nanoparticles for nanoremediation -- Part III: Conjugating nanoremediation to other remediation strategies -- Chapter. 12. Green-based nanomaterial and plants in nanophytoremediation strategies -- Chapter. 13. Main interactions of green nanomaterials and microorganisms on nanoremediation protocols -- Part. IV: Safety aspects and analysis of nanoremediation -- Chapter. 14. Supporting nanotechnology safety through nanoinformatics -- Chapter. 15. Conventional strategies of environmental pollution remediation versus Green Nanoremediation -- Chapter. 16. Using nanoremediation strategies: cost/benefit analysis -- Chapter. 17. Strategies to evaluate nanoremediation efficiency.

Kurzfassung: This book focuses on green nanoremediation addressing aspects related to the use of nanomaterials generated through green synthesis protocols to efficiently restore polluted environs. Nanomaterials’ characteristics such as large surface area, capacity to easily reach into contaminated sites, good reactivity, and possibility of being developed to present photocatalytic activity and/or to deal with targeted substances by chemical surface modification are useful specially to perform remediation. As an alternative to conventional physicochemical methods, the green-based synthesis protocols reject the use of harmful reagents, prevent waste production, apply renewable energy source and/or materials, and consider in first place offering the smallest negative impact possible to living beings and to the ecosystem. Green synthesis in nanotechnology field involves the use of seaweeds, bacteria, cyanobacteria, yeasts, fungi, plants (living ones, biomass, extracts) and/or bio-derived products to generate the nanomaterials. The introductory chapter will be dedicated to nanomaterials’ characteristics that enable them to be used in environmental remediation. The first part of the book will be dedicated to organic and inorganic pollution and the threats they pose to living forms; advantages, disadvantages and mechanisms of nanoremediation; comparison between conventional strategies of environmental pollution remediation and the green nanoremediation; carbon-based and non-carbon-based green nanomaterials capable of promoting environs’ remediation; cost/benefits of using nanomaterials and nanoinformatics to a safe nanotechnology. The second part will be dedicated to green nanoremediation of water and soil, microbe-based, algae-based and plant-based synthesis of nanomaterials to nanoremediation. This part will also contain chapters dedicated to relevant nanomaterials for green nanoremediation protocols, nano-phytoremediation strategies, strategies to evaluate the efficiency of protocols related to this kind of remediation, main interactions of green nanomaterials and microbes during nanoremediation and, as a consequence of it, biocompatibility of green nanomaterials. This book’s main purpose is to offer readers extensive knowledge on green nanoremediation as a feasible strategy to fight pollution's harmful consequences and clean environmental pollution, but also present the challenges that should be surpassed.

Materialart: Online-Ressource

Seiten: XI, 388 p. 96 illus., 77 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031305580

URL: https://doi.org/10.1007/978-3-031-30558-0

DOI: 10.1007/978-3-031-30558-0

DDC: 363.73

Sprache: Englisch

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Managing Persistent Organic Pollutants in India : Case Studies on Vapi and Surat, Gujarat (2023)

Chakraborty, Paromita. [editor.] ; Nizzetto, Luca. [editor.] ; Bharat, Girija. [editor.] ; [weitere]

Cham :Springer Nature Switzerland :

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Schlagwort(e): Pollution. ; Environmental policy. ; Environmental health. ; Pollution. ; Environmental Policy. ; Environmental Health.

Beschreibung / Inhaltsverzeichnis: Chapter 1 – Status of POPs Pollution in India -- Chapter 2 – Regulatory framework, Policies and Programs in POPs Management in India -- Chapter 3 – POPs Associated with Plastic Waste -- Chapter 4 – Transport of POPs from Source to Sea -- Chapter 5 – Environmental Monitoring Techniques of Targeted POPs -- Chapter 6 – Environmental and health impact -- Chapter 7 – International Regulatory Frameworks and Best Practices in Management of POPs -- Chapter 8 – Overview of Use and Release Sources of the Seven New POPs -- Chapter 9 – Analysis of Gaps in Management of POPs in India -- Chapter 10 – Case Studies-Tapi and Daman Ganga River Basins in Gujarat. .

Kurzfassung: Persistent Organic Pollutants (POPs) are a class of chemicals that are persistent, bio accumulative and toxic (PBT), which are restricted for use under the Stockholm Convention. They adversely impact the environment, human and animal health. Most of the POPs are semi-volatile organic compounds (SVOCs) and known to have a long-range transport potential and are often deposited in colder climate and found in places away from the regions they are produced. POPs are usually hydrophobic (i.e., “water-hating”) and lipophilic (i.e., “fat-loving”) chemicals, due to which they bind to solids, particularly organic matter, and fatty tissues in both marine and terrestrial environments. As a result, POPs may move up the food chain. This book focuses on determining the sources, fate, analytical techniques of detecting POPs as well as their health impacts. It further dwells on the regulatory aspects, management of POPs, best environmental practices (BEPs), Indian and international case studies, gaps in understanding the regulatory aspects. A few key recommendations for the way forward form the concluding chapters of this book.

Materialart: Online-Ressource

Seiten: X, 200 p. 27 illus., 26 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031313110

Serie: Emerging Contaminants and Associated Treatment Technologies,

URL: https://doi.org/10.1007/978-3-031-31311-0

DOI: 10.1007/978-3-031-31311-0

DDC: 363.73

Sprache: Englisch

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Mushrooms with Therapeutic Potentials : Recent Advances in Research and Development (2023)

Agrawal, Dinesh Chandra. [editor.] ; Dhanasekaran, Muralikrishnan. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Therapeutics. ; Internal medicine. ; Fungi. ; Mycology. ; Microbiology. ; Medical microbiology. ; Pharmacology. ; Therapeutics. ; Internal Medicine. ; Fungi. ; Medical Microbiology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Mushrooms as Promising Therapeutic Resources: Review and Future Perspectives -- Chapter 2. Medicinal Mushrooms for Respiratory Health -- Chapter 3. Therapeutic and Prophylactic Potential of Medicinal Mushrooms in COVID-19 -- Chapter 4. Influences of Edible Mushrooms on Dynamic and Diversity of Gut Microbiota -- Chapter 5. Mushrooms – From Traditional Remedies to the Modern Therapeutics -- Chapter 6. Biopharmaceutical Potential of Ophiocordyceps sinensis for Human Health -- Chapter 7. Anticancer Potential of Ganoderma lucidum and İts Relevant Modes of Action -- Chapter 8. Cognitive Enhancing Effects of Medicinal Mushrooms: A Potential Neuroprotective Implication in Dementias -- Chapter 9. Potential of Medicinal Mushrooms in Human Health and Welfare: An Overview -- Chapter 10. Mycotherapeutics Reduce Nephrotoxicity and Renal Diseases -- Chapter 11. Proteomic Research on the Therapeutic Properties of Medicinal Mushrooms -- Chapter 12. Cordyceps militaris (L.): Medicinal aspects in terms of ethnobotanical and pharmacological perspectives -- Chapter 13. Mycotherapeutics Affecting Dopaminergic Neurotransmission to Exert Neuroprotection -- Chapter 14. Biological Activities of Some Edible Mushrooms -- Chapter 15. Nephroprotective Effects of Four Ganoderma Species -- Chapter 16. Mechanisms Involved in Edible Mushrooms' Health Beneficial Effects -- Chapter 17. Mycotherapy (Medicinal Mushrooms) as a Potential Treatment for Epilepsy -- Chapter 18. Natural vs. Synthetic Psilocybin: The Same or Completely Different? -- Chapter 19. Preventative and Curative Properties of Reishi and Maitake Mushrooms in Cancer.

Kurzfassung: The book presents new and novel perceptions about ailments alleviating the effects of several mushroom species. Also, the book highlights the curative role of medicinal mushrooms on some peripheral and central diseases. Various chapters in the book (primarily reviews) have been dedicated to providing the therapeutic efficacy of mushrooms against respiratory illnesses, gut microbiota, COVID-19, dementia, epilepsy, mental ailments, cancers, cardiovascular, kidney-related diseases, and other common pathologies. Thus, medicinal mushrooms are current and future consumable healthcare products that usually exhibit nourishing properties and possess prophylactic and therapeutic values with minimal adverse effects and contraindications. The book focuses on Sustainable Development Goal (SDG 3) to promote healthy lives and well-being for all. Medical, pharmacy, nursing, and CAM (complementary and alternative medicine) students, practitioners, scholars, researchers, other healthcare professionals, and general readers are this book’s potential audience. The book can be adopted as a textbook for undergraduate and graduate courses so that the therapeutic potential of mushrooms can reach a wider audience. This book strives to create a new resource for the future use of medicinal mushrooms in various disorders. .

Materialart: Online-Ressource

Seiten: XX, 509 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811995507

URL: https://doi.org/10.1007/978-981-19-9550-7

DOI: 10.1007/978-981-19-9550-7

DDC: 615

Sprache: Englisch

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Endolysosomal Voltage-Dependent Cation Channels (2023)

Wahl-Schott, Christian. [editor.] ; Biel, Martin. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Physiology. ; Cytology. ; Life sciences. ; Pharmacology. ; Physiology. ; Cell Biology. ; Life Sciences.

Beschreibung / Inhaltsverzeichnis: Part I: Physiological Functions of Endo-lysosomal Cation Channels -- NAADP-Mediated Ca2+ Signalling -- NAADP-Dependent TPC Current -- NAADP-Evoked Ca2+ Signaling: The DUOX2–HN1L/JPT2–Ryanodine Receptor 1 Axis -- TPC Functions in the Immune System -- Lysosomal Ion Channels and Lysosome– 1 Organelle Interactions -- TRPML1 and TFEB, an Intimate Affair -- Lysosomal Potassium Channels -- Part II Structure and Composition of TPC and TRPML Channels -- Structure and Function of Plant and Mammalian TPC Channels -- A Structural Overview of TRPML1 and the TRPML Family -- Endo-Lysosomal Two-Pore Channels and Their Protein Partners -- Part III: Tools and Methods to Characterize Endolysosomal Cation Channels -- Electrophysiological Techniques on the Study of Endolysosomal Ion Channels -- The Plant Vacuole as Heterologous System to Characterize the Functional Properties of TPC Channels -- Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels -- Characterization of Endo-Lysosomal Cation Channels Using Calcium Imaging.

Kurzfassung: This book covers the molecular structures and the cellular and in vivo function of endosomes and lysosomes, i.e. intracellular vesicles which are involved in many cellular processes such as endocytosis, intracellular trafficking, degradation of material from inside (e.g. autophagy) and outside the cell as well as exocytosis. Membranes of endolysosomal organelles contain an amazing number and diversity of ion channels. These ion channels are the topic of the present book that focusses on describing the structure, the biophysical properties, physiological functions of endolysosomal ion channels at the molecular, cellular and in vivo level. .

Materialart: Online-Ressource

Seiten: X, 304 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031315237

Serie: Handbook of Experimental Pharmacology, 278

URL: https://doi.org/10.1007/978-3-031-31523-7

DOI: 10.1007/978-3-031-31523-7

DDC: 615

Sprache: Englisch

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Autophagy in Stem Cell Maintenance and Differentiation (2023)

Shravage, Bhupendra V. [editor.] ; Turksen, Kursad. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Stem cells. ; Cytology. ; Developmental biology. ; Cancer Stem Cells. ; Cell Biology. ; Developmental Biology and Stem Cells.

Beschreibung / Inhaltsverzeichnis: Assays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis.

Kurzfassung: This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understanding of the role of autophagy in stem cells, including germline stem cells. Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.

Materialart: Online-Ressource

Seiten: VIII, 288 p. 41 illus., 34 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031173622

Serie: Stem Cell Biology and Regenerative Medicine, 73

URL: https://doi.org/10.1007/978-3-031-17362-2

DOI: 10.1007/978-3-031-17362-2

DDC: 571.978

Sprache: Englisch

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Methods in Cancer Stem Cell Biology (2023)

Afify, Said M. ; Seno, Masaharu.

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Biology Technique. ; Stem cells. ; Cancer Biology. ; Biological Techniques. ; Cancer Stem Cells. ; Stem Cell Biology.

Beschreibung / Inhaltsverzeichnis: 1. On the origin of cancer -- 2. Culture of Cells: Basic Principles -- 3. Stem cell culture from embryos -- 4. Reprogramming of normal cells -- 5. Maintenance of human Pluripotent Stem Cells -- 6. Identification of cancer stem cells by different molecular markers -- 7. Enrichment of Cancer Stem Cell from malignant tumor -- 8. Isolation of single clonal cell from primary cultured cells and establishment of a cancer stem cell line -- 9. Artificial Generation of Cancer Stem Cells from Normal Stem Cells -- 10. Quick method to assess non-mutagenic carcinogens with iPS cells -- 11. Self-renewal potential of caner stem cells -- 12. Differentiation potential of cancer stem cells in vitro -- 13. Tumor Angiogenesis by cancer stem cells in vivo -- 14. Invasion and Metastatic potential of cancer stem cells in vitro -- 15. Metastatic potential of cancer stem cells In Vivo- 16. Anchorage-independent cell growth assay for Cancer Stem Cells: Tumorigenic assay in vitro -- 17. Tumorigenic potential of cancer stem cells in vivo -- 18. Development of immunoliposomes using monoclonal antibodies targeting cancer stem cells -- 19. In-vitro evaluation of anti-cancer stem cell drugs -- 20. In vitro Tumoroid Model Using Cancer Stem Cells.

Kurzfassung: This book describes the use of stem cells and cancer stem cell generation in the inflammatory microenvironment (cancer-inducing niche) using induced pluripotent stem cells. It provides step-by-step techniques and manuals for studying stem cell and cancer stem cell generation with different applications in cancer research. The development of induced pluripotent stem cells has provided a new approach to studying cancer initiation by producing cancer stem cells without introducing mutations or foreign genes. The book features the research of the authors’ group, which was the first to generate cancer stem cells from stem cells in the presence of inflammatory conditions. The 20 chapters if this book cover topics such as generating pluripotent stem cells, converting normal stem cells to cancer stem cells, enriching, isolating and evaluating cancer stem cells. Methods for evaluating the characteristics of cancer stem cells and possible therapies against them are also discussed. The book provides easy-to-follow protocols that help researchers in the study of cancer stem cells. Illustrations help readers understand how the method of cancer stem cell generation can be applied as an essential method for assessing the carcinogenic potential of various non-mutagenic compounds. It will be a useful resource for graduate students, researchers, technicians, and physicians working in academic, hospital, and pharmaceutical settings. .

Materialart: Online-Ressource

Seiten: XVII, 243 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819913312

URL: https://doi.org/10.1007/978-981-99-1331-2

DOI: 10.1007/978-981-99-1331-2

DDC: 571.978

Sprache: Englisch

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Polymeric Micelles: Principles, Perspectives and Practices (2023)

Singh, Sachin Kumar. [editor.] ; Gulati, Monica. [editor.] ; Mutalik, Srinivas. [editor.] ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Pharmaceutical chemistry. ; Drug delivery systems. ; Pharmacology. ; Pharmaceutics. ; Drug Delivery.

Beschreibung / Inhaltsverzeichnis: 1. Synthesis, self-assembly and functional chemistry of Amphiphilic block copolymers -- 2. Advances in polymer optimisation for enhanced drug delivery -- 3. Dynamics of Micelle Formation -- 4. Types of Polymeric Micelles for Controlled Drug Release -- 5. Drug Solubilization and Drug Release from Polymeric Micelles -- 6. Physical and Analytical Techniques used for the Characterization of Polymeric Micelles -- 7.Stimuli-sensitive polymeric micelles for biomedical applications -- 8.Nucleic acid-based micellar therapy for the treatment of different diseases -- 9. Polymeric micelles in the delivery of therapeutic phytoconstituents -- 10. Diagnostic applications of surface-engineered polymeric micelles -- 11. Ligand conjugated polymeric micelles for targeted delivery of drug payloads in cancer therapy -- 12. Polymeric Micelles in the Delivery of Proteins -- 13. Regulatory aspects for polymeric micelles -- 14. Toxicological and regulatory challenges in design and development of polymeric micelles -- 15. Stability of polymeric micelles and their regulatory status.

Kurzfassung: This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. It provides information on the synthesis of amphiphilic block copolymers and their types, functional chemistry for targeting and sensing, and biomedical applications. The book further provides the possibilities for designing PMs in a range of drug delivery approaches. The book addresses the molecular parameters of amphiphilic block copolymers that are required for functionalizing PMs for drug delivery applications. Additionally, the book presents recent advances in applications of PMs such as co-delivery, sensing, theranostics, delivery of nucleic acids, and proteins. Towards the end, it discusses different physico-chemical strategies to enhance the stability and drug retention of polymeric micelles and reviews the preclinical and clinical toxicity and immunogenicity-related aspects of polymeric micelles. This book is an invaluable source for academics, research, and industry professionals working in the field of polymeric micelles and drug delivery.

Materialart: Online-Ressource

Seiten: XV, 294 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819903610

URL: https://doi.org/10.1007/978-981-99-0361-0

DOI: 10.1007/978-981-99-0361-0

DDC: 615

Sprache: Englisch

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Hypoxia in Cancer: Significance and Impact on Cancer Therapy (2023)

Mukherjee, Sukhes. [editor.] ; Kanwar, Jagat Rakesh. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Cancers. ; Cancer Therapy. ; Cancer Biology. ; Tumour Immunology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Hypoxia and its Biological Implications for Cancer Therapy -- Chapter 2. Hypoxia's function in cancer -- Chapter 3. Role of Hypoxia and Reactive Oxygen Species in cancer biology -- Chapter 4. Hypoxic tumor microenvironment: driver for cancer progression -- Chapter 5. Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression -- Chapter 6. Hypoxia Regulated Gene Expression and Metastasis -- Chapter 7. piRNA based cancer therapy in hypoxic tumor -- Chapter 8. MicroRNA Signatures of Tumor Hypoxia -- Chapter 9. Hypoxia and the Metastatic Cascade -- Chapter 10. Hypoxia and Extra Cellular Matrix-major drivers of tumor Metastasis -- Chapter 11. Role of Hypoxia in Cancer Therapy – Introduction -- Chapter 12. Hypoxic regulation of telomerase gene expression in cancer -- Chapter 13. CRISPR/Cas9-editing-based modeling of tumor hypoxia -- Chapter 14. Tumor-on-a-chip: Microfluidic models for Hypoxic tumor microenvironment -- Chapter 15. Imaging the Hypoxic Tumor microenvironment in cancer models -- Chapter 16. Hypoxia-targeting drugs as new cancer chemotherapy agents Hypoxia-targeting drugs as new cancer chemotherapy agents - Molecular Insights -- Chapter 17. Identification of Hypoxia targeting drugs in the tumor microenvironment and prodrug Strategies for Targeting Tumor Hypoxia -- Chapter 18. Hypoxia Induced Apoptosis in Cancer Development -- Chapter 19. Hypoxia in drug resistance and radioresistance.

Kurzfassung: This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.

Materialart: Online-Ressource

Seiten: XV, 447 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819903139

URL: https://doi.org/10.1007/978-981-99-0313-9

DOI: 10.1007/978-981-99-0313-9

DDC: 571.978

Sprache: Englisch

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Winning Grants (2023)

Ekins, Sean.

Cham :Springer Nature Switzerland :

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Schlagwort(e): Pharmacology. ; Pharmaceutical chemistry. ; Pharmacology. ; Pharmaceutics.

Beschreibung / Inhaltsverzeichnis: Preface -- Abbreviations -- Chapter 1 – Why you need this book and why I wrote it -- Chapter 2 – What you need to do before you write a grant -- Chapter 3 – The idea -- Chapter 4 – Go solo or collaborate? -- Chapter 5 – What the entrepreneur needs to know -- Chapter 6 – The grant package -- Chapter 7 – The main event – writing it -- Chapter 8 – Edit / Polish / Shine / Repeat -- Chapter 9 – Are you ready to submit it? -- Chapter 10 - Post submission steps to win the grant -- Afterthoughts -- Index -- About the Author.

Kurzfassung: As an academic or a small business owner, you will need to write grants at some point in your career. Writing them though is not enough, what you also need to know is how to win grants. Much has been written about writing grants, the mysterious special ability called ‘grantsmanship’, so it occurred to me that there is a need to come at this differently and spill the beans. The difficulty in getting a grant, in particular an NIH grant like an R01 in the USA is often described, it is competitive and gets tougher every year. Your proposal therefore must stand out, it must connect with the reviewers. This is true for all types of grants, give the reviewer what they want always. But also, you need to connect to the program officer, the committee that ultimately makes funding decisions and you must take care of a myriad of other details outside of the main event which is describing the “science”. This means you cannot rely on just out-writing the competition, it is more than that as you have to out-think, out-strategize and out-schmooze them. If you have been continually funded for decades that is terrific, but if you want to keep being funded there is no guarantee what got you there will keep you there. What was a hot technology 4-5 years ago is not the new thing anymore, you will need to do something different, but what? You therefore need to not only think about writing great grants, you need to put it into practice and win them. Having written and won grants from the NIH and DOD over the past 17 years (and longer by the time you read this) I possess a valuable perspective. Each grant and study section will be different. Whether a big or small grant it does not seem to make a difference the reviewers will critique your efforts, they may not like it, they may reject your ideas or they may love it. You have some small degree of control until the proposal leaves your hands or more correctly you click ‘submit’. You will need to differentiate your grant from the hundreds of others in many ways, but you cannot change who you are, your history so how you describe yourself and team will also have an impact. You could spend hundreds of hours on your proposal or just a day and the outcome might still be the same. This small book is a summary of my own personal experiences and will provide some advice that will help you learn how to do a better job of winning grants. This book is written by a scientist who writes the grants and develops commercial products; Provides a unique perspective on what you need to write better grants; Teaches you how to continually win grants; This book provides examples from the authors own grant applications; The reader will be inspired to start a company to win small business grants.

Materialart: Online-Ressource

Seiten: XIX, 106 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031275166

Serie: AAPS Introductions in the Pharmaceutical Sciences, 17

URL: https://doi.org/10.1007/978-3-031-27516-6

DOI: 10.1007/978-3-031-27516-6

DDC: 615

Sprache: Englisch

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The Mesentery and Inflammation (2023)

Coffey, J. Calvin. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Neurosciences. ; Psychiatry. ; Medical genetics. ; Clinical health psychology. ; Human physiology. ; Pharmacology. ; Neuroscience. ; Psychiatry. ; Medical Genetics. ; Health Psychology. ; Human Physiology.

Beschreibung / Inhaltsverzeichnis: Introduction -- Development, anatomy and histology of the mesentery -- The mesenteric intersitium -- Mesnteric organ lymphatics -- The mesentery as an immunological organ -- Bacterial translocation to the mesentery -- The microbiome of mesenteric lymh nodes -- Mesenteric Adenopathy and adenitis -- The effects of mesenteric inflammation on the intestine -- The mesentery as an ADME organ -- Targteing the mesentery using surgery -- Future directions.

Kurzfassung: The volume summarizes the most recent advances in our understanding of the mesentery and explains the how these are important in inflammation. It comprises a series of state of the art chapters by leading authorities in each area. It explains how recent advances in our understanding of the mesenteric organ, have advanced the diagnosis and treatment abdominal and systemic conditions including cancer, inflammatory bowel disease and endocrine conditions such as diabetes, and circulatory disorders such as atherosclerosis. .

Materialart: Online-Ressource

Seiten: X, 226 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031177743

Serie: Progress in Inflammation Research, 90

URL: https://doi.org/10.1007/978-3-031-17774-3

DOI: 10.1007/978-3-031-17774-3

DDC: 615

Sprache: Englisch

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Evolutionary Dynamics of Malignancy : The Genetic and Environmental Causes of Cancer (2023)

Jackson, Robert C.

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Cancer Animal models. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Models. ; Cancer Therapy. ; Cancer Genetics and Genomics. ; Cancer Microenvironment.

Beschreibung / Inhaltsverzeichnis: Chapter 1: Cancer as a Disease of Cell Proliferation -- Chapter 2: Genetic and Chromosomal Instability -- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function -- Chapter 4: The DNA Damage Checkpoint -- Chapter 5: Dynamics of the Spindle Assembly Checkpoint -- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance -- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy -- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy -- Chapter 9: The Cancer Stem Cell and Tumour Progression -- Chapter 10: Evading the antitumour immune response -- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention -- Chapter 12: In science, all conclusions are provisional.

Kurzfassung: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.

Materialart: Online-Ressource

Seiten: XIV, 269 p. 96 illus., 58 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031325731

URL: https://doi.org/10.1007/978-3-031-32573-1

DOI: 10.1007/978-3-031-32573-1

DDC: 571.978

Sprache: Englisch

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Meta-analysis in Clinical Research: Principles and Procedures (2023)

Kumar, Anoop.

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Medical sciences. ; Drug development. ; Biologicals. ; Biopharmaceutics. ; Pharmacology. ; Preclinical Research. ; Biologics.

Beschreibung / Inhaltsverzeichnis: Chapter 1_Introduction -- Chapter2_Systematic literature review (SLR) -- Chapter 3_Registration and software’s -- Chapter 4_Quality Assessment of Studies -- Chapter 5_Extraction and Analysis of data -- Chapter 6_Models in Meta-analysis -- Chapter 7_Heterogeneity and Publications bias -- Chapter 8_Sensitivity and subgroup analysis -- Chapter 9_Meta-regression -- Chapter 10_Plots in Meta-analysis -- Chapter 11_Network Meta-analysis -- Chapter 12_Common mistakes -- Chapter 13_Challenges -- Chapter 14_Future Perspectives -- Chapter 15_Future perspectives.

Kurzfassung: This book provides conceptual information on the various processes involved in meta-analysis. It examines the importance of meta-analysis for the analyses of clinical data to draw a valid conclusion using suitable software. The initial sections of the book introduce meta-analysis, how to perform a systematic literature review (SLR), quality assessment of studies, extraction, and analysis of data. The subsequent section of the book contains information on advanced topics including, meta-regression, network meta-analysis, issues, mistakes, and future perspectives. In summary, the book provides a statistical method for combining the results of different studies on the same topic and resolving conflicts among studies. This book is written with the intent to allow a wide range of readers including students, researchers, and health care professionals, including physicians, nurses, pharmacists, and paramedical, and is also helpful for a beginner who would like to do a meta-analysis.

Materialart: Online-Ressource

Seiten: XXII, 119 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819923700

URL: https://doi.org/10.1007/978-981-99-2370-0

DOI: 10.1007/978-981-99-2370-0

DDC: 615

Sprache: Englisch

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Precision Medicine (2023)

Cascorbi, Ingolf. [editor.] ; Schwab, Matthias. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Internal medicine. ; Cancer. ; Pharmacology. ; Internal Medicine. ; Cancer Biology.

Beschreibung / Inhaltsverzeichnis: Part 1. Pharmacogenomics -- Building evidence in RCTs Implementation of pharmacogenomics in healthcare in the UK -- Part 2. Precision medicine in clinical entities -- Precision medicine in therapy of non-solid cancer -- Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia -- Precision medicine in Asthma -- Precision medicine in Diabetes -- Precision Medicine in Antidepressants Treatment -- Precision Medicine in Neuropathic Pain -- Part 3. Techniques in Precision Medicine -- Imaging techniques in pharmacological precision medicine -- Challenges to use NGS data to optimize drug therapy -- Part 4. Economics -- Pharmacoeconomics in precision medicine. .

Kurzfassung: The rapidly increased understanding of the molecular background of complex diseases facilitated the development of highly advanced therapeutic concepts. Such concepts aiming to consider individual signatures of genomic and proteomic biomarkers including pharmacogenomics as well as advanced diagnostic tools have been successfully implemented in clinical practice in various fields leading to significant improvement of treatment successes. This volume gives an up-to-date overview on applications of precision medicine in various clinical entities, on advanced techniques as well as on economic considerations.

Materialart: Online-Ressource

Seiten: X, 283 p. 100 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031400476

Serie: Handbook of Experimental Pharmacology, 280

URL: https://doi.org/10.1007/978-3-031-40047-6

DOI: 10.1007/978-3-031-40047-6

DDC: 615

Sprache: Englisch

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Photoprotective Green Pharmacology: Challenges, Sources and Future Applications (2023)

Kannaujiya, Vinod K. [editor.] ; Sinha, Rajeshwar P. [editor.] ; Rahman, Md. Akhlaqur. [editor.] ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Pharmaceutical chemistry. ; Medicinal chemistry. ; Pharmacology. ; Pharmaceutics. ; Medicinal Chemistry.

Beschreibung / Inhaltsverzeichnis: Chapter 1: Radiation biology: historical background, sources and complications -- Chapter 2: Algal radioprotective phytochemicals: Sources and potential applications -- Chapter 3: Bio-prospecting of photoprotective compounds in algae -- Chapter 4: Unraveling fungal radioprotectants and their applications -- Chapter 5: Recent advances in metabolomics and molecular genomics for the production of photoprotective compounds -- Chapter 6: Bioprospecting and evolutionary significance of radioprotectors in non-flowering lower plants -- Chapter 7: Radioprotective phytochemicals: diversity, efficacy, application and commercialization -- Chapter 8: Impacts of climate alterations in the biosynthesis of defensive natural products -- Chapter 9: Cancer therapeutics: mechanism of action, radiation toxicity and drug formulation -- Chapter 10: Role of nanotechnology in the development of radioprotective formulations -- Chapter 11: Radioprotective effects of nutraceuticals and food products -- Chapter 12: Bioprospecting of radioprotective compounds in bacterial community -- Chapter 13: Pharmacology of synthetic and natural radioprotactants: application and consequences in cancer therapeutics -- Chapter 14: Immunochemistry: consequences and mechanism of protection in chemotherapeutics -- Chapter 15: Radioprootective therapeutics: recent trends and future applications.

Kurzfassung: This book illustrates the role of photoprotective and radioprotective metabolites from natural sources. Various classes of radioprotective metabolites derived from cyanobacteria, algae, fungi, bryophytes, pteridophytes, gymnosperms, and higher plants have been explained to reinforce the current knowledge in this field. In addition, the book elucidates the potential applications of these metabolites in pharmaceutics, cosmetics, and biomedical sciences that will help develop commercial products in modern anti-radiation therapeutics. Topics such as stress tolerance environmental strategies, evolutionary tendency, and biosynthetic route of radioprotective compounds for cost-effective large-scale industrial production of the metabolites are also covered in the book. This book will add to the understanding of radioprotective mechanisms and curative measures for various deleterious diseases leading to cancer development. This volume also offers the latest insights into current and upcoming issues that arise from solar and atomic radiations and their amelioration by inherent radioprotective mechanisms of green plants. This book benefits readers from academia, industry, colleges, and research students to better understand the impacts of various radiations and the development of radioprotective green compounds.

Materialart: Online-Ressource

Seiten: XIII, 264 p. 62 illus., 27 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819907496

URL: https://doi.org/10.1007/978-981-99-0749-6

DOI: 10.1007/978-981-99-0749-6

DDC: 615

Sprache: Englisch

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Aquaporins (2023)

Yang, Baoxue. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Proteins . ; Human physiology. ; Biological transport. ; Cell membranes. ; Pharmacology. ; Protein Biochemistry. ; Human Physiology. ; Membrane Trafficking.

Beschreibung / Inhaltsverzeichnis: 1. Classification and Gene Structure of Aquaporins -- 2. Protein Structure and Modification of Aquaporins -- 3. Expression Regulation and Trafficking of Aquaporins -- 4. Transport Characteristics of Aquaporins -- 5. Non-transport Functions of Aquaporins -- 6. The Evolutionary Aspects of Aquaporin Superfamily -- 7. Aquaporins in Nervous System -- 8. Aquaporins in Cardiovascular System -- 9. Aquaporins in Respiratory System -- 10. Aquaporins in Digestive System -- 11. Aquaporins in Urinary System -- 12. Aquaporins in Reproductive System -- 13. Aquaporins in Immune System.-14. Aquaporins in Eye -- 15. Aquaporins in Skin -- 16. Aquaporins in Glandular Secretion -- 17. Aquaporins in Fetal Development -- 18. Aquaporins in Diabetes Insipidus -- 19. Aquaporins in Edema -- 20. Aquaporins in Obesity.-21. Aquaporins in Tumor -- 22. Aquaporin Inhibitors -- 23. Non-aquaporin Water Channels.-24. Methods to Measure Water Permeability.

Kurzfassung: This book provides a state-of-the-art report on our current understanding of aquaporins and the future direction of the field. Aquaporins (AQPs) are a group of water-channel proteins that are specifically permeable to water and other small molecules, such as glycerol and urea. To date thirteen water-channel proteins (AQP0 – AQP12) have been cloned and the mechanisms and physiological functions of water transport across biological membranes have long been the subject of interest. Recent advances in the molecular biology and physiology of water transport have yielded new insights into how and why water moves across cell membranes, and studies on aquaporin knockout mouse models suggest that aquaporins are involved in the development of some diseases and they may be useful targets of research into selective-inhibitor drugs. By focusing on the advances made over the last 30 years in the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of aquaporins in mammalian cell membranes, this book provides novel insights into further mechanisms and the physiological significance of water and some small molecule transport in mammals in order to stimulate further research in new directions. In the second version, fourteen chapters will be updated base on the most recent research articles. Ten new chapters will be added.

Materialart: Online-Ressource

Seiten: VIII, 365 p. 1 illus. , online resource.

Ausgabe: 2nd ed. 2023.

ISBN: 9789811974151

Serie: Advances in Experimental Medicine and Biology, 1398

URL: https://doi.org/10.1007/978-981-19-7415-1

DOI: 10.1007/978-981-19-7415-1

DDC: 615

Sprache: Englisch

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Genetics and Epigenetics of Breast Cancer (2023)

Roy, Madhumita. ; Biswas, Jaydip. ; Datta, Amitava.

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Cancer Genetic aspects. ; Cancer Treatment. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Cancer Therapy.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Breast cancer -- Chapter 1.1. Epidemiology -- Chapter 1.2. Etiology -- Chapter 1.3. Types of breast cancer -- Chapter 1.4. Signs and symptoms -- Chapter 1.5. Stages -- Chapter 1.6. Diagnosis -- Chapter 1.7. Treatment -- Chapter 2. Genetic landscape of breast carcinogenesis -- Chapter 2.1. Hormone receptor positive breast cancer -- Chapter 2.1. Her2 positive breast cancer -- Chapter 2.2. Triple negative breast cancer -- Chapter 3. Epigenetic involvement in breast carcinogenesis -- Chapter 3.1. Histone modification -- Chapter 3.2. DNA methylation -- Chapter 3.3. miRNA -- Chapter 4. Breast cancer control -- Chapter 4.1. Conventional drugs targeting Genetic and Epigenetics in Breast cancer -- Chapter 4.2. Pitfalls of conventional therapy -- Chapter 4.3. Natural remediation -- Chapter 5. Conclusion.

Kurzfassung: This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment.

Materialart: Online-Ressource

Seiten: X, 87 p. 13 illus., 7 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811999253

URL: https://doi.org/10.1007/978-981-19-9925-3

DOI: 10.1007/978-981-19-9925-3

DDC: 571.978

Sprache: Englisch

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Cancer Stem Cells: Basic Concept and Therapeutic Implications (2023)

Islam, Farhadul. [editor.] ; Lam, Alfred K. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Stem cells. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Stem Cells. ; Cancer Therapy. ; Cancer Biology. ; Cancer Genetics and Genomics.

Beschreibung / Inhaltsverzeichnis: 1. Introduction and perspective in carcinogenesis -- 2. Origin and Development of Cancer Stem Cells -- 3. Detection and Isolation of Cancer Stem Cells -- 4. The genetic and epigenetic landscape of cancer stem cells -- 5. Metabolism of Cancer Stem Cell -- 6. Plasticity of Cancer Stem Cell -- 7. Cancer Stem Cells in Cancer Initiation and Progression -- 8. Cancer Stem Cells and Metastasis -- 9. Roles of Cancer Stem Cells in Therapy resistance and Disease Recurrence -- 10. Novel therapeutics targeting cancer stem cell surface markers -- 11. Therapeutics targeting cancer stem cells signalling pathways -- 12. Cancer stem cells therapeutics delivery and EPR effect -- 13. Immunotherapy against cancer stem cells -- 14. Engineering nanobody targeting cancer stem cells -- 15. Biological barriers for drug delivery to cancer stem cells -- 16. Cancer Stem Cell Markers in Haematological Malignancies -- 17. Diagnostic and Prognostic Significance of Cancer Stem Cells Surface Markers -- 18. Diagnostic and prognostic implications of cancer stem cells transcription factors -- 19. Diagnostic and prognostic significance of intracellular markers of CSCs in patients with cancers. .

Kurzfassung: This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.

Materialart: Online-Ressource

Seiten: XVI, 372 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819931859

URL: https://doi.org/10.1007/978-981-99-3185-9

DOI: 10.1007/978-981-99-3185-9

DDC: 571.978

Sprache: Englisch

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Introduction to Quality by Design in Pharmaceutical Manufacturing and Analytical Development (2023)

Breitkreitz, Márcia Cristina. [editor.] ; Goicoechea, Hector. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Pharmaceutical chemistry. ; Pharmacology. ; Pharmaceutics.

Beschreibung / Inhaltsverzeichnis: Part 1: Quality by Design (QbD) -- Chapter 1. Pharmaceutical Quality by Design (QbD) overview and major elements -- Chapter 2. Fundamentals of design of experiments and optimization: designs for factor screening and data analysis in pre-response surface methodology -- Chapter 3. Fundamentals of design of experiments and optimization: experimental designs in response surface methodology -- Chapter 4. Fundamentals of design of experiments and optimization: data modeling in response surface methodology -- Chapter 5. Quality by Design in pharmaceutical product and process development -- Chapter 6. A Quality by Design update on nano-drug delivery systems -- Chapter 7. Control strategies of solid dosage forms by PAT tools -- Part 2: Analytical Quality by Design (AQbD) -- Chapter 8. Analytical Quality by Design Fundamentals, Compendial and Regulatory Perspectives -- Chapter 9. Analytical Target Profile (ATP) and Method Operable Design Region (MODR) -- Chapter 10: Quality by Design applications to development of analytical methods for quality control of pharmaceuticals -- Chapter 11. Design of Experiments Applied to the Extraction of Active Compounds. .

Kurzfassung: Written by twenty-five authors from academia, pharmaceutical industry and Pharmacopeias worldwide, this monograph covers the fundamentals and applications of Quality by Design (QbD) and Analytical Quality by Design (AQbD) in a practical and didactic manner. The book starts by describing the motivation and the urgent need for the implementation of the QbD framework in pharmaceutical development, along with the definition of its major elements: Quality Target Product Profile (QTTP), Critical Quality Attributes (CQAs), Critical Process Parameters (CPPs), Critical Material Attributes (CMAs) and the importance of using multivariate methods of Design of Experiments (DOE). The concept of life cycle and regulatory perspectives are discussed. Three chapters are entirely dedicated to DOE theory from screening to optimization designs. Moreover, a comprehensive discussion on modelling and data treatment is presented. Practical aspects of QbD and DOE for pharmaceutical product and process of different dosage forms is included, as well as a practical guide of the input process variables, material attributes, intermediate, and final quality attributes for the most representative pharmaceutical processes. Analytical Quality by Design (AQbD) is also deeply explored, including risk analysis, definitions of Analytical Target Profile (ATP), Method Operable Design Region (MODR) and the life cycle approach, taking into account the compendial and regulatory perspectives. A detailed example of a new chromatographic method for the quality control of a pharmaceutical topical product based on the AQbD procedure is shown. Finally, advanced statistical approaches and DOE methods for extraction studies of bioactive compounds are also presented. The vast amount of information offered in this book provides a comprehensive perspective on QbD, AQbD and DOE principles, essential tools for modern pharmaceutical and analytical development.

Materialart: Online-Ressource

Seiten: X, 266 p. 62 illus., 46 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031315053

Serie: AAPS Introductions in the Pharmaceutical Sciences, 10

URL: https://doi.org/10.1007/978-3-031-31505-3

DOI: 10.1007/978-3-031-31505-3

DDC: 615

Sprache: Englisch

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Cytokine and Chemokine Networks in Cancer (2023)

Mir, Manzoor Ahmad. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Tumors Immunological aspects. ; Therapeutics. ; Cancers. ; Tumour Immunology. ; Therapeutics.

Beschreibung / Inhaltsverzeichnis: Chapter 1_Introduction to Cancer -- Chapter 2_Expression pattern of Chemokines in Cancer -- Chapter 3_Implications of Cytokine-Chemokine Heterogenity in Cancer -- Chapter 4_Cytokine and chemokines networks in cancer stemness -- Chapter 5_Cytokine and chemokines networks in angiogeneis -- Chapter 6_Role of Cytokine-Chemokine cascades in Epithelial to Mesenchymal Transition -- Chapter 7_Role of Chemokines in establishment of Metastatic Niche -- Chapter 8_CXCL12-CXCR4 axis in Metastasis -- Chapter 9_Chemokine and cytokine networks in the tumor microenvironment -- Chapter 10_CXCL9, CXCL10, CXCL11/CXCR3 axis and Immune Activation -- Chapter 11_CXCL8-CXCR1/2 axis in cancer and inflammatory diseases -- Chapter 12_Cytokine and Chemokine Networks in Therapeutic Resistance -- Chapter 13_Prognostic and diagnostic significance of Chemokines and cytokines in cancer -- Chapter 14_Therapeutic implications of Chemokines and cytokines networks in cancer -- Chapter 15_Chemokines in cancer therapy.

Kurzfassung: Cytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.

Materialart: Online-Ressource

Seiten: XVII, 440 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819946570

URL: https://doi.org/10.1007/978-981-99-4657-0

DOI: 10.1007/978-981-99-4657-0

DDC: 571.978

Sprache: Englisch

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Redox Regulation and Therapeutic Approaches in Cancer (2023)

Bansal, Mohinder Pal.

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Metabolism. ; Cancer Treatment. ; Biochemistry. ; Oxidation-reduction reaction. ; Cancer Metabolism. ; Cancer Therapy. ; Redox Biology.

Beschreibung / Inhaltsverzeichnis: 1. ROS, redox regulation and signaling in cancer cells -- 2. ROS and redox regulation/signaling and metabolism in cancer stem cells -- 3. . ROS/Redox regulation with dietary phytochemicals and role in anticancer activity -- 4. ROS/Redox signaling and apoptosis/necroptosis/autophagy in cancer -- 5. Cancer Metastasis, ROS/redox signaling and PCD resistance/redox metabolism -- 6. Immune system, redox signaling and cancer immunity -- 7. P53, ROS- redox regulation signaling, metabolic reprogramming and autophagy in cancer -- 8. Cell cycle, DNA damage-repair systems and impact of redox regulation in cancer -- 9. ROS, redox regulation and anticancer therapy -- 10. Perspectives in ROS/redox regulation cancer therapy.

Kurzfassung: This book aims to provide an association of the major redox-sensitive pathways and networks involved in cancer. The initial chapter of the book discusses basic information about oxidative stress, its generation, and regulation (redox regulation or redox homeostasis) via cell signaling in normal and cancer cells. The book also explores antioxidants and metabolic events in cancer cells compared to normal cells. It further covers the application of nanoparticles in redox regulation in cancer cells. The role of redox regulation in cancer therapy, its influence, and its involvement in programmed cell death (PCD), metastasis, immune system, p53, and cell cycle/DNA damage repair pathways have been discussed in separate chapters. It further reviews the importance of dietary phytochemicals in redox regulation in normal and cancer pathophysiology. Towards the end, the book focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells.

Materialart: Online-Ressource

Seiten: XI, 431 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819973422

URL: https://doi.org/10.1007/978-981-99-7342-2

DOI: 10.1007/978-981-99-7342-2

DDC: 571.978

Sprache: Englisch

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Targeting Epigenetics in Inflammatory Lung Diseases (2023)

Gupta, Gaurav. [editor.] ; Oliver, Brian G. [editor.] ; Dua, Kamal. [editor.] ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Epigenetics. ; Respiratory organs. ; Physiology. ; Pharmacology. ; Epigenetics. ; Respiratory Physiology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction to Lung Diseases -- Chapter 2. Introduction to Epigenetics -- Chapter 3._Epigenetic mechanisms in Inflammation -- Chapter 4. Epigenetic regulator of inflammatory gene expression -- Chapter 5. Epigenetics of Asthma -- Chapter 6_. Epigenetic optimization in chronic obstructive pulmonary disease (COPD -- Chapter 7. Epigenetics of Lung Cancer -- Chapter 8. Epigenetics of Pulmonary Tuberculosis -- Chapter 9. Epigenetics of Idiopathic Pulmonary Fibrosis -- Chapter 10. Epigenetics of influenza-A virus infection -- Chapter 11. Epigenetics of rhinovirus -- Chapter 12. Epigenetics of SARS-Cov2 (Covid-19) -- Chapter 13. Epigenetics of Haemophilus Influenzae -- Chapter 14. Future Prospects and Challenges -- Chapter 15. Targeting epigenetics in pulmonary arterial hypertension.

Kurzfassung: This book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis, idiopathic pulmonary fibrosis and pulmonary infections. It also explores post-translational modifications in DNA and histones for improving the understanding of lung diseases. This book helps in understanding the epigenetic mechanisms towards the development of novel diagnostic and therapeutic approaches. Further, the book provides insight into the underlying molecular mechanisms involved in the epigenetic regulation of inflammation, which may have novel implications in designing small molecule inhibitors that target the epigenetic machinery for the effective treatment of a variety of inflammation‑related diseases. This book is a valuable resource for academics, research and industry professionals working in respiratory biology.

Materialart: Online-Ressource

Seiten: XV, 266 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819947805

URL: https://doi.org/10.1007/978-981-99-4780-5

DOI: 10.1007/978-981-99-4780-5

DDC: 615

Sprache: Englisch

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Formation Mechanism and Control Strategies of Haze in China (2023)

He, Hong. [editor.] ; Wang, Xinming. [editor.] ; Wang, Yuesi. [editor.] ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Environmental chemistry. ; Inorganic chemistry. ; Environmental sciences Mathematics. ; Cogeneration of electric power and heat. ; Fossil fuels. ; Chemical processes. ; Pollution. ; Environmental Chemistry. ; Inorganic Chemistry. ; Mathematical Applications in Environmental Science. ; Fossil Fuel. ; Process Chemistry.

Beschreibung / Inhaltsverzeichnis: Introduction -- Atmospheric oxidation and secondary particle formation -- Haze Source Tracing -- Numerical Model of Atmospheric Haze -- Research and Development, Industrialization, and Application of Advanced Instruments -- Multi-Pollutant Collaborative Treatment Technology and Special Equipment of Atmospheric Haze.

Kurzfassung: This book summarizes the new major research findings about formation mechanism and control strategies of haze in China, including basic theories, key technologies, equipment and platforms and the applications and implementations of control technologies, in implementing the Strategic Priority Research Program (Class B) of Chinese Academy of Sciences. Different types of air pollution processes experienced by the developed countries in different stages are out-breaking simultaneously in China in the recent years and resulting a new type of “haze chemistry smog” pollution, which is different from the “London smog” and the “Los Angeles photochemical smog”. This book provides a useful reference for related researchers, engineers and policy-makers engaged in atmospheric pollution research, prevention and control in China and other countries.

Materialart: Online-Ressource

Seiten: XV, 250 p. 122 illus., 106 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811969560

Serie: Advanced Topics in Science and Technology in China, 66

URL: https://doi.org/10.1007/978-981-19-6956-0

DOI: 10.1007/978-981-19-6956-0

DDC: 363.73

Sprache: Englisch

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Micro and Nanoplastics in Soil : Threats to Plant-Based Food (2023)

Maddela, Naga Raju. [editor.] ; Reddy, Kondakindi Venkateswar. [editor.] ; Ranjit, Pabbati. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pollution. ; Soil science. ; Botany. ; Pollution. ; Soil Science. ; Plant Science.

Beschreibung / Inhaltsverzeichnis: Part1. Soil Pollution by Micro and Nanoplastics -- Chapter1. Soil Pollution by Micro and Nanoplastics: An overview -- Chapter2. Soil Pollution by Micro and Nanoplastics: Sources, Fate and Impact -- Chapter3. Abundance and Distribution of MPs and NPs in Soil – A Global Scenario -- Chapter4. Methodology of assessing micro plastics and nano plastics in the environment -Recent advances in the practical approaches -- Chapter5. Persistence of Micro and Nanoplastics in Soil -- Chapter6. Microplastics as a carrier of antibiotic resistance genes - a revision of literatureiz -- Part2. Trophic transfer of Micro and Nanoplastics -- Chapter7. Phytoaccumulation of Micro and Nanoplastics: Root Uptake -- Part3. Toxicity of Micro and Nanoplastics -- Chapter8. Toxicity Effects of Micro and Nanoplastics in Terrestrial Environment -- Chapter9. Ecological Impacts and Toxicity of Micro and Nanoplastics in Agroecosystem -- Chapter10. Micro and Nanoplastics on Plant Functionalities -- Chapter11. Cellular and Animal Toxicities of Micro and Nanoplastics -- Part4. Bioremediation of Micro and Nano plastics- polluted soil -- Chapter12. Restoration of Micro/Nanoplastics-contaminated Soil by Phytoremediation -- Chapter13. Bacterial Remediation of Micro/Nanoplastics-contaminated soil -- Chapter14. Mycoremediation of Micro and Nano Plastics (MNPs) – contaminated Soils -- Chapter15. Emerging Techniques for the Mitigation of Micro and Nanoplastics in Soil -- Chapter16. Micro and Nanoplastics in Agricultural Soils: Challenges and Future directions.

Kurzfassung: This contributed volume gives a state-of-the-art overview of microplastics and nanoplastics (MPs and NPs) in soils and their relationship with growing plants. Through chapters contributed by a wide variety of researchers, the book offers readers an understanding of MP and NP adsorption, uptake, and effects, as well as implications for trophic transmission, food safety, and security. Cutting-edge topics such as trophic transfer and remediation of MPs and NPs in soil samples are also addressed. The book begins with a primer on terrestrial MPs and NPs, their effects on terrestrial plants, and how these contaminants affect human populations. From there, the volume is split into four sections which address both problems caused by MPs and NPs in soil and potential remediation solutions. The first section deals with the mechanics of how MPs and NPs pollute soils and how toxic chemicals affect the soil profile and its flora, fauna and microbes. The second section of the book discusses trophic transfer of MPs and NPs from roots to shoot, shoot to leaves, and then to fruits. The third section details the threats to humans that are present as a result of MPs and NPs in soils. The fourth and last section gives covers bioremediation techniques that can be employed in order to reclaim polluted soils.

Materialart: Online-Ressource

Seiten: XX, 431 p. 58 illus., 42 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031211959

URL: https://doi.org/10.1007/978-3-031-21195-9

DOI: 10.1007/978-3-031-21195-9

DDC: 363.73

Sprache: Englisch

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Sustainable Advanced Technologies for Industrial Pollution Control : Proceedings of ATIPC 2022 (2023)

Mazumder, Debabrata. [editor.]

Cham :Springer Nature Switzerland :

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Schlagwort(e): Pollution. ; Sustainability. ; Refuse and refuse disposal. ; Industrial policy. ; Pollution. ; Sustainability. ; Waste Management/Waste Technology. ; Regulation and Industrial Policy.

Beschreibung / Inhaltsverzeichnis: Chapter 1: Water decontamination through Thiamethoxam removal using DL menthol-octanoic acid Deep Eutectic Solvent : Molecular dynamics insights -- Chapter 2: Methyl Red dye abatement from aqueous solution using Calcium Ferrite and Manganese Ferrite magnetic nanocomposite: Kinetics and isotherm study -- Chapter 3: Adsorption of Fluoride onto PANI-Cl jute fibre - designing higher flow rate and initial concentration column reactor from a batch reactor -- Chapter 4: Biosynthesis of Nano Zero valent Iron (nZVI) using Shorea robusta Leaf Extract and its application in UV-assisted Photocatalytic Degradation of Methyl Orange -- Chapter 5: Method Development for detection of 2-Methylpyridine by High Performance Liquid Chromatography -- Part 2 - Industrial effluent treatment, reuse and conservation -- Chapter 6: Importance of cost functions for biological treatment of wastewater -- Chapter 7: Removal of heavy metals by Laterite soil -- Chapter 8: Removal of Methylene Blue from wastewater by Red Sandy soil-Based Alkali activated binder -- Chapter 9: Assessment and Treatment of iron from industrial wastewater using activated carbon derived from Parkia Speciosa pod -- Chapter 10: Activated Carbon developed from Phumdi biomass and Deccan Hemp for adsorption of Methylene Blue -- Chapter 11: An experimental study of Metanil Yellow dye remediation using Fe-Mn Bimetal oxide composites -- Chapter 12: Optimization of electrocoagulation process parameters using magnesium electrodes for treating pharmaceutical wastewater containing salicylic acid -- Chapter 13: Optimization of process parameters for biodegradation of Cresol by mixed bacterial culture using Response Surface Methodology -- Chapter 14: Biological degradation of Cresol containing wastewater using mixed microbial culture in presence of heavy metals -- Part 3 - Monitoring of industrial emission and control -- Chapter 15: Development of a simplistic model for the prediction of reactive air pollutants in the atmosphere -- Chapter 16: Controlling Air and Metal pollution in industrial area Singrauli, India: Role of plants -- Part 4 - Industrial solid waste management -- Chapter 17: Enhancing the dewatering ability of sludge by locally available biomass -- Chapter 18: Production of Xylose from Water Hyacinth Biomass (WHB) (lignocellulosic waste) for Xylitol production: waste to wealth -- Chapter 19: A simplistic mathematical model for two-stage Anaerobic Digestion of plastic wastes -- Part 5 - Handling and disposal of hazardous waste -- Chapter 20: Modeling migration of Cr(VI) contaminant through Clay Liner using Hydrus-3d -- Chapter 21: Electrokinetic remediation of total Chromium from contaminated soil -- Chapter 22: Low-Cost recovery of Cadmium from wastewater by soil bacteria -- Part 6 - Case Studies on industrial pollution control -- Chapter 23: Tannery waste management in India: A case study -- Chapter 24: Removal of natural organics and selected antibiotics using PAC and AL electrode: A study for Jumar River -- Chapter 25: Quantification of floating plastics using UAV images and Identification of Microplastics in Ukkadam tank -- Chapter 26: Study of wastewater treatment in Hindustan Coca-Cola plant at Khurda -- Part 7 - Innovative technologies in industrial waste management -- Chapter 27: In Vitro Performance Analysis of Ti and Zn doped Hydroxyapatite made from waste Eggshells -- Chapter 28: Production of non-toxic, non-polluting herbal soaps using plant extracts having anti-microbial activity -- Chapter 29: Decolourization of Textile Dye RR 141 using electrochemical process.

Kurzfassung: This proceedings volume constitutes peer-reviewed full-length papers contributed by the Authors and tailored on various thematic areas of the 3rd International Conference on “Advanced Technologies for Industrial Pollution Control” (ATIPC – 2022). The areas of research covered by these papers include but are not limited to: •Water quality monitoring and treatment in industrial area •Industrial effluent treatment, reuse and conservation •Monitoring of industrial emission and control •Industrial solid waste management •Handling and disposal of hazardous waste •Case Studies on industrial pollution control •Innovative technologies in industrial waste management.

Materialart: Online-Ressource

Seiten: XVI, 408 p. 232 illus., 175 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031375965

Serie: Springer Proceedings in Earth and Environmental Sciences,

URL: https://doi.org/10.1007/978-3-031-37596-5

DOI: 10.1007/978-3-031-37596-5

DDC: 363.73

Sprache: Englisch

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Mercury Toxicity : Challenges and Solutions (2023)

Kumar, Nitish. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Environmental health. ; Environmental management. ; Sustainability. ; Pollution. ; Environmental Health. ; Environmental Management. ; Sustainability.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Environmental Mercury Exposure – A Continuing Challenge -- Chapter 2. Mercury Contamination in Food : An Overview -- Chapter 3. Research Trend on Mercury (Hg) Contamination of Water Resources: A Bibliometric Review -- Chapter 4. Impact of mercury and its toxicity on health and environment: a general perspective -- Chapter 5. Effects of Mercury: Neurological and Cellular Perspective -- Chapter 6. Mercury Adsorption using Biowaste Biochar: A Green Technology Approach -- Chapter 7. Removal of Mercury of Wastewater by Different Natural Biomasses -- Chapter 8. Microbial Remediation of Mercury: An Overview -- Chapter 9. Remediation Strategies of Environmental Mercury: An Overview of its Environmental Persistence, Associated Threats and Health Impacts -- Chapter 10. Mercury Remediation: Easing Biochar Approach -- Chapter 11. Application and Development Strategies of Nano-Adsorbents on Mercury Remediation -- Chapter 12. Amputation of Mercury from Wastewater: Perspectives of Action Methods -- Chapter 13. Environmental Mercury Toxicity and its Bioremediation -- Chapter 14. Biosorption of Mercury from Aqueous Solutions by Biosorbents.

Kurzfassung: This book presents mercury toxicity with respect to remediation and health issues. It covers sources of mercury contamination, its impact on human health, and prospective remediation by both bioremediation and phytoremediation with the application of recent advanced techniques such as genetic engineering and nanotechnology. Both anthropogenic activities and natural processes cause the release of mercury into different spheres of the environment resulting in severe adverse impacts. Increased anthropogenic discharge of mercury leads to disturbance in its natural biogeochemical cycle, which results in unenviable diseases and hazardous health effects. Mercury pollution is responsible for causing neurobehavioral, kidney, heart, gastrointestinal, liver, and other diseases. Many published works about the impact of mercury on health are also available worldwide; however, there is no complete understanding available on toxicological studies of mercury that covers the broader spectrum of findings ranging from sources of exposure to mercury toxicity to its remediation strategies. This book brings together a diverse group of environmental science, sustainability, and health researchers to address the challenges posed by global mass poisoning caused by mercury contamination. The book also proposes solutions to contamination through multi-disciplinary approaches. The book contains three sections. The first part describes the different sources and distribution of mercury in soil and plant ecosystems. The second part explains the health risks linked to mercury toxicity. The third part addresses sustainable mercury toxicity mitigation strategies and the potential applications of recent technology in providing solutions. This book is a valuable resource to students, academics, researchers, and environmental professionals working in the field of mercury contamination.

Materialart: Online-Ressource

Seiten: XI, 374 p. 72 illus., 45 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819977192

Serie: Environmental Science and Engineering,

URL: https://doi.org/10.1007/978-981-99-7719-2

DOI: 10.1007/978-981-99-7719-2

DDC: 363.73

Sprache: Englisch

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Xenobiotics in Urban Ecosystems : Sources, Distribution and Health Impacts (2023)

Singh, Rishikesh. [editor.] ; Singh, Pardeep. [editor.] ; Tripathi, Sachchidanand. [editor.] ; [weitere]

Cham :Springer International Publishing :

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Schlagwort(e): Pollution. ; Environmental chemistry. ; Urban ecology (Biology). ; Industrial microbiology. ; Pollution. ; Environmental Chemistry. ; Urban Ecology. ; Industrial Microbiology.

Beschreibung / Inhaltsverzeichnis: 1-Xenobiotics in the urban ecosystems: Current status and trend analysis -- 2-Urban water cycle: A potential source and sink of xenobiotics -- 3-Xenobiotics in the urban soils: Sources and environmental concerns -- 4-Major strategies for the assessment of xenobiotics in the urban soils -- 5-Advancements in the analytical techniques for precise xenobiotic assessment -- 6-Xenobiotics in urban soils: Bioavailability and threat levels -- 7-Transport and metabolism of xenobiotics in the urban ecosystem -- 8-Xenobiotics and soil microbial community in the urban ecosystem -- 9-Impact of xenobiotics on urban agriculture/crops -- 10-Xenobiotics and urban plants: impact and threat levels -- 11-Food chain contamination and impact of xenobiotics on human health -- 12-Biotransformation of xenobiotics in the urban ecosystem -- 13-Phytoremediation and xenobiotics: exploring the potential of selected plants -- 14-Remediation strategies for xenobiotics in urban soils -- 15-Socioeconomic impacts and policy measures for xenobiotics in urban ecosystems -- 16-Management and regulatory aspects of xenobiotics: Government initiatives.

Kurzfassung: This volume provides state-of-the-art knowledge on xenobiotics in urban ecosystems, addressing a wide range of related issues, such as xenobiotic types and chemical composition, environmental fate, remedial approaches, regulatory policies and socioeconomic impacts. The book incorporates theoretical and practical aspects pertaining to xenobiotics to assess their threat level in urban environments, while determining appropriate responses and remediation measures to curb harmful impacts and prevent future contaminations. The book will be of interest to soil scientists, ecological engineers, agriculturists, urban policymakers, students and researchers working in the field of urban agriculture and environmental sciences.

Materialart: Online-Ressource

Seiten: XV, 433 p. 53 illus., 49 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031357756

URL: https://doi.org/10.1007/978-3-031-35775-6

DOI: 10.1007/978-3-031-35775-6

DDC: 363.73

Sprache: Englisch

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Geospatial Analytics for Environmental Pollution Modeling : Analysis, Control and Management (2023)

Mushtaq, Fayma. [editor.] ; Farooq, Majid. [editor.] ; Mukherjee, Alok Bhushan. [editor.] ; [weitere]

Cham :Springer Nature Switzerland :

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Schlagwort(e): Pollution. ; Geographic information systems. ; Environmental management. ; Pollution. ; Geographical Information System. ; Environmental Management.

Beschreibung / Inhaltsverzeichnis: Chapter 1: Types of Environmental Pollution and Its Effects On The Environment and Society -- Chapter 2: Geostatistical Methods and Framework For Pollution Modelling -- Chapter 3: GIS-based Modelling for Estimation of Water Quality Parameters: A Review -- Chapter 4: Air Quality Monitoring Using Geospatial Technology and Field Sensors -- Chapter 5: Geospatial Techniques and Methods for Monitoring and Assessment of Soil Contaminants -- Chapter 6: Geospatial Modelling and Framework For the Detection and Mapping of Noise Pollution -- Chapter 7: Urban Areas and Air Pollution: Causes, Concerns and Mitigation -- Chapter 8: Constructing The Dynamics of Water Quality Parameters Using Geospatial Technology and In Situ Observations -- Chapter 9: Urban Air Quality Monitoring and Modelling Using Ground Monitoring, Remote Sensing and GIS -- Chapter 10: Assessment of Soil Contamination Using Remote Sensing and Spatial Techniques -- Chapter 11: Noise Pollution Modelling Using Gis Techniques in Srinagar City -- Chapter 12: Geostatistics Interceded Groundwater Quality Study With Emphasis on Kriging Across the Andhra Pradesh State Of India -- Chapter 13: Air Quality and Human Health -- Chapter 14: Significance of Geo-Visualization Tools For Pollution Monitoring -- Chapter 15: Environmental Pollution Control Measures And Strategies: An Overview Of Recent Developments -- Chapter 16: Environmental Legislation and Global Initiatives.

Kurzfassung: This book aims to provide a comprehensive study on various aspects of environmental pollution dynamics using geospatial technology and modeling techniques. The utility of geospatial technology will be demonstrated for the effective study of environmental pollution, as space and location are very important for effective environmental health surveillance. The timeliness of the work is due to the increasing relevance of geospatial technology applications in environmental health investigations. Moreover, different types of pollution are covered in detail, including air and soil, all of which are analyzed using latest Remote Sensing and GIS technology. The basics of environmental pollution and its impacts are covered in the book's first part, while the second part focuses on the use of geospatial technology in investigating and modeling various instances of environmental pollution. The third part discusses policy measures for mitigating environmental pollution hazards, using geospatial analyses and data to craft informed policy decisions. The primary audience for the book is researchers working in the field of environmental pollution with incorporation of geospatial technology, including upper-level undergraduate and graduate students taking courses in remote sensing and its environmental applications. The secondary audience is academicians, planners, environmentalists and policymakers working in the field of environment protection and management.

Materialart: Online-Ressource

Seiten: XVII, 437 p. 120 illus., 113 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031453007

URL: https://doi.org/10.1007/978-3-031-45300-7

DOI: 10.1007/978-3-031-45300-7

DDC: 363.73

Sprache: Englisch

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Environmental Risks Posed by Microplastics in Urban Waterways (2023)

He, Beibei. ; Liu, An. ; Ayoko, Godwin. ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Refuse and refuse disposal. ; Water. ; Hydrology. ; Pollution. ; Waste Management/Waste Technology. ; Water.

Beschreibung / Inhaltsverzeichnis: Microplastics as Emerging Pollutants in Urban Waterways -- Factors Influencing MPs Presence in Urban Waterways -- Risk Associated with MPs in Urban Waterways -- Case Study—Risks Posed by MPs Presence and Transport in Brisbane River Sediments, Australia -- Practical Implications and Recommendations for Further Research.

Kurzfassung: This book presents comprehensive knowledge regarding the spatial and temporal distributions, influential factors, interactions with coexisting contaminants, migration behavior, and environmental risk posed by microplastics (MPs) in urban waterways. It provides a novel theoretical approach for the combined risks from MPs and coexisting contaminants, and advanced three-dimensional modeling techniques for different MPs’ dispersal and transport behaviors in urban waterways. Additionally, this book presents a scientifically robust investigation on the correlations between various influential factors and heterogeneity in relation to MP presence in river systems. The new knowledge presented would be of particular interest to readers such as urban water management professionals, urban plastic waste regulators, decision-makers, urban planners, and water environment quality model developers, as it provides practical solutions and recommendations for plastic-polluted river quality improvement from a risk management perspective.

Materialart: Online-Ressource

Seiten: VIII, 78 p. 52 illus., 51 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819906284

Serie: SpringerBriefs in Water Science and Technology,

URL: https://doi.org/10.1007/978-981-99-0628-4

DOI: 10.1007/978-981-99-0628-4

DDC: 363.73

Sprache: Englisch

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Notch Signaling in Embryology and Cancer : Molecular Biology of Notch Signaling (2020)

Reichrath, Jörg. [editor.] ; Reichrath, Sandra. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.

Beschreibung / Inhaltsverzeichnis: Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling -- Overview of Basic Mechanisms of Notch Signaling in Development and Disease -- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate -- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling -- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster -- Molecular Regulation of Notch Signaling by Gremlin -- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex -- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss -- Insulin–dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation -- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF-κB and beyond -- Index.

Kurzfassung: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.

Materialart: Online-Ressource

Seiten: XIII, 172 p. 32 illus., 31 illus. in color. , online resource.

Ausgabe: 2nd ed. 2020.

ISBN: 9783030364229

Serie: Advances in Experimental Medicine and Biology, 1227

URL: https://doi.org/10.1007/978-3-030-36422-9

DOI: 10.1007/978-3-030-36422-9

DDC: 571.978

Sprache: Englisch

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Coronary Artery Disease: Therapeutics and Drug Discovery (2020)

Wang, Miao. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Cardiology. ; Therapeutics. ; Heart Surgery. ; Pharmacology. ; Cardiology. ; Therapeutics. ; Cardiac Surgery.

Beschreibung / Inhaltsverzeichnis: Coronary Artery Disease: From Mechanism to Clinical Practice -- Evidence in guidelines for treatment of coronary artery disease -- Revascularization For Coronary Artery Disease: Principle And Challenges -- Antithrombotic drugs: pharmacology and perspectives -- Lipid modifying drugs: pharmacology and perspectives -- Anti-hypertensive drugs: pharmacology and perspectives -- Pharmaceutical treatment for Heart failure -- Drug discovery for coronary artery disease.

Kurzfassung: This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.

Materialart: Online-Ressource

Seiten: IX, 339 p. 7 illus., 4 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811525179

Serie: Advances in Experimental Medicine and Biology, 1177

URL: https://doi.org/10.1007/978-981-15-2517-9

DOI: 10.1007/978-981-15-2517-9

DDC: 615

Sprache: Englisch

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Pediatric Pharmacotherapy (2020)

Kiess, Wieland. [editor.] ; Schwab, Matthias. [editor.] ; van den Anker, Johannes. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Pediatrics. ; Pharmacology. ; Pediatrics.

Beschreibung / Inhaltsverzeichnis: Anti-epileptic drugs in pediatrics -- Current and new therapies for Duchenne Muscular Dystrophy -- Lysosomal diseases -- Mitochondriopathies -- Endocrinology thyroid, pituitary, growth stimulant, growth reduction -- Bone disease – bisphosphonates -- Diabetes type 1 and 3 (insulin; sulfonylurea; others) -- Diabetes type 2 (metformin etc.) -- Dermatology – part 1 urticaria, atopic dermatitis -- Dermatology part 2, ichtyosis, psoriasis -- Cardiovascular part 1- catcholamines, inotropic -- Cardiovascular part 2 – antiarhythmica, anti hypertensives -- Nephrology – dialysis -- How to use drugs in obese children and adolescents -- Haematology – CSFs, erythropoietin -- Antiretroviral/HIV -- Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life -- Antihelminth treatment -- Inflammatory bowel disease -- Constipation; laxatives -- Psychiatric diseases in children and adolescents -- Oncology – cell reducing agents part 1, part 2, part 3 -- Immunosuppressants – organ transplantation -- Bone marrow/stem cell transplantation -- Narcotic sparing approaches and the shift towards paracetamol in neonatal intensive care -- Disorders of puberty: pharmacotherapeutic strategies for management.

Kurzfassung: This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.

Materialart: Online-Ressource

Seiten: VIII, 538 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030504946

Serie: Handbook of Experimental Pharmacology, 261

URL: https://doi.org/10.1007/978-3-030-50494-6

DOI: 10.1007/978-3-030-50494-6

DDC: 615

Sprache: Englisch

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Tumor Microenvironment : Molecular Players – Part B (2020)

Birbrair, Alexander. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.

Beschreibung / Inhaltsverzeichnis: MicroRNAs in the tumor microenvironment -- The Impact of Estrogen in the Tumor Microenvironment -- The non-bone related role of RANK/RANKL signaling in cancer -- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment -- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma -- COX-2 Signaling in the Tumor Microenvironment -- Renin–angiotensin system in the tumor microenvironment -- Stem cell secreted factors in the tumor microenvironment -- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy -- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms -- Index.

Kurzfassung: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Materialart: Online-Ressource

Seiten: XIV, 162 p. 22 illus., 21 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030502249

Serie: Advances in Experimental Medicine and Biology, 1277

URL: https://doi.org/10.1007/978-3-030-50224-9

DOI: 10.1007/978-3-030-50224-9

DDC: 571.978

Sprache: Englisch

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Immunotherapy for Gastrointestinal Malignancies (2020)

Vadde, Ramakrishna. [editor.] ; Nagaraju, Ganji Purnachandra. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Biochemical markers. ; Immunotherapy. ; Cancers. ; Biomarkers. ; Immunotherapy.

Beschreibung / Inhaltsverzeichnis: 1 Tumor heterogeneity: challenges and perspectives for gastrointestinal cancer therapy -- 2 immune composition of gastrointestinal tract of Gut -- 3 Immunomarkers for detection of GI malignancies -- 4 Immuno-therapeutics of gastrointestinal malignancies -- 5 Immune cell therapy against gastrointestinal tract cancers -- 6 Immune checkpoint inhibitors in gastrointestinal malignancies -- 7 Monoclonal Antibody therapy against gastrointestinal tract cancers -- 8 Therapeutic Vaccines for Gastrointestinal Malignancies -- 9 Immuno-Oncology of Oesophageal Cancer -- 10 Association between IL6 gene polymorphisms and gastric cancer risk: A meta-analysis of case-control studies -- 11 Immuno-oncology of colorectal cancer -- 12 Immune targets in colorectal cancer -- 13 Applications of computational biology in gastrointestinal malignancies. .

Kurzfassung: This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies. .

Materialart: Online-Ressource

Seiten: XII, 251 p. 34 illus., 27 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811564871

Serie: Diagnostics and Therapeutic Advances in GI Malignancies,

URL: https://doi.org/10.1007/978-981-15-6487-1

DOI: 10.1007/978-981-15-6487-1

DDC: 571.978

Sprache: Englisch

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Vaccination Strategies Against Highly Variable Pathogens (2020)

Hangartner, Lars. [editor.] ; Burton, Dennis R. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human physiology. ; Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human Physiology.

Beschreibung / Inhaltsverzeichnis: Successful Vaccines -- Immunogenicity and Immunodominance in Antibody Responses -- Immunogen Design -- Adjuvants -- Tools to screen vaccines -- Targeting glycans on human pathogens for vaccine design -- BnAbs and highly antigenically variable pathogens.

Kurzfassung: Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine. .

Materialart: Online-Ressource

Seiten: VII, 180 p. 16 illus., 15 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030580049

Serie: Current Topics in Microbiology and Immunology, 428

URL: https://doi.org/10.1007/978-3-030-58004-9

DOI: 10.1007/978-3-030-58004-9

DDC: 615

Sprache: Englisch

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Autophagy in tumor and tumor microenvironment (2020)

Bhutia, Sujit Kumar. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Immunology. ; Medical microbiology. ; Molecular genetics. ; Stem cells. ; Cell death. ; Cancer Biology. ; Immunology. ; Medical Microbiology. ; Molecular Genetics. ; Stem Cell Biology. ; Cell Death.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy – An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.

Kurzfassung: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.

Materialart: Online-Ressource

Seiten: VII, 280 p. 38 illus., 37 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811569302

URL: https://doi.org/10.1007/978-981-15-6930-2

DOI: 10.1007/978-981-15-6930-2

DDC: 571.978

Sprache: Englisch

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Drug Stability and Chemical Kinetics (2020)

Akash, Muhammad Sajid Hamid. [editor.] ; Rehman, Kanwal. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Pharmaceutical chemistry. ; Pharmacology. ; Pharmaceutics.

Beschreibung / Inhaltsverzeichnis: 1 Principles of pharmaceutical analysis in drug stability and chemical kinetics -- 2 Guidelines for drug stability and stability testing -- 3 Chemical kinetics and its applications in drug stability -- 4 Methods and protocols for drug stability studies -- 5 Physical basis of degradation of pharmaceutical products -- 6 Role of microbiological degradation on drug stability -- 7 Role of decomposition on drug stability -- 8 Role of catalysis in drug stability -- 9 Analytical techniques for the assessment of drug stability -- 10 Stability of pharmaceutical products -- 11 Role of kinetic models in drug stability -- 12 Stability studies of vaccines -- 13 Stability studies of proteinous compounds -- 14 Stability studies of extemporaneous pharmaceutical products -- 15 Stability studies of parenteral products -- 16 Stability studies of solid dosage forms.

Kurzfassung: This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics. .

Materialart: Online-Ressource

Seiten: XIV, 284 p. 22 illus., 13 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811564260

URL: https://doi.org/10.1007/978-981-15-6426-0

DOI: 10.1007/978-981-15-6426-0

DDC: 615

Sprache: Englisch

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Tumor Microenvironment : Extracellular Matrix Components – Part A (2020)

Birbrair, Alexander. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.

Beschreibung / Inhaltsverzeichnis: The tumor microenvironment: focus on extracellular matrix -- Keratan Sulphate in the Tumour Environment -- Hyaluronan in the tumor microenvironment -- Fibronectin in the tumor microenvironment -- Matrix metalloproteinases role in tumor microenvironment -- Flipping the Molecular Switch: Influence of Perlecan and its Modifiers in the Tumor Microenvironment -- Heparan sulfate in the tumor microenvironment -- The role of Glypican-1 in the tumour microenvironment -- Index.

Kurzfassung: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components with the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newer generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book will be an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Materialart: Online-Ressource

Seiten: XI, 181 p. 29 illus., 24 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030401467

Serie: Advances in Experimental Medicine and Biology, 1245

URL: https://doi.org/10.1007/978-3-030-40146-7

DOI: 10.1007/978-3-030-40146-7

DDC: 571.978

Sprache: Englisch

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Current Advances in the Science of Osteosarcoma : Research Perspectives: Tumor Biology, Organ Microenvironment, Potential New Therapeutic Targets, and Canine Models (2020)

Kleinerman, Eugenie S. [editor.] ; Gorlick, Richard. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Medical microbiology. ; Cytology. ; Pediatrics. ; Cancer Biology. ; Medical Microbiology. ; Cell Biology. ; Pediatrics.

Beschreibung / Inhaltsverzeichnis: The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies -- Genomics and the Immune Landscape of Osteosarcoma -- RECQ DNA Helicases and Osteosarcoma -- Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma -- Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma -- Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response -- Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: 2019 update -- The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets -- Autophagy in OS -- Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs -- Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment -- Comparative Immunology and Immunotherapy of Canine Osteosarcoma -- Index.

Kurzfassung: This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.

Materialart: Online-Ressource

Seiten: XIII, 233 p. 34 illus., 23 illus. in color. , online resource.

Ausgabe: 2nd ed. 2020.

ISBN: 9783030430856

Serie: Advances in Experimental Medicine and Biology, 1258

URL: https://doi.org/10.1007/978-3-030-43085-6

DOI: 10.1007/978-3-030-43085-6

DDC: 571.978

Sprache: Englisch

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Heparanase : From Basic Research to Clinical Applications (2020)

Vlodavsky, Israel. [editor.] ; Sanderson, Ralph D. [editor.] ; Ilan, Neta. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.

Beschreibung / Inhaltsverzeichnis: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.

Kurzfassung: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Materialart: Online-Ressource

Seiten: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030345211

Serie: Advances in Experimental Medicine and Biology, 1221

URL: https://doi.org/10.1007/978-3-030-34521-1

DOI: 10.1007/978-3-030-34521-1

DDC: 571.978

Sprache: Englisch

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Handbook of 200 Medicinal Plants : A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications (2020)

Akbar, Shahid.

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Pharmacy. ; Medicinal chemistry. ; Pharmacology. ; Pharmacy. ; Medicinal Chemistry.

Beschreibung / Inhaltsverzeichnis: Abelmoschus maschatus -- Abrus precatorius -- Abutilon indicum -- Acacia catechu -- Acacia nilotica (A. arabica) -- Achillea millefolium -- Achyranthes aspera -- Aconitum napellus -- Acorus calamus -- Adiantum venustum (Adiantun capillus-veneris) -- Aegle marmelos -- Agrimonia eupatorium.-Alhagi maurorum -- Alkanna tinctoria -- Allium cepa -- Allium sativum -- Aloe vera -- Alpinia galangal -- Alpinia officinarum -- Alstonia scholaris -- Althaea officinalis -- Ammi majus -- Anacardium occidentale -- Anacyclus pyrethrum -- Andrographis paniculata -- Anethum graveolens -- Anthemis nobilis -- Apium graveolens -- Argemone Mexicana -- Aristolochia bracteolata -- Aristolochia fontanesii (A. longa) -- Aristolochia indica -- Aristolochia rotunda -- Artemisia absinthium -- Artemisia vulgaris -- Asparagus adscendens -- Asparagus officinalis -- Asparagus racemosus -- Atropa belladonna -- Azadirachta indica -- Bacopa monnieri -- Bauhinia tomentosa -- Berberis Aristata -- Berberis vulgaris -- Bombyx mori -- Borago officinalis -- Boswellia serrata -- Brassica nigra -- Butea monosperma -- Caccinia macranthera var. glauca (C. glauca) -- Caesalpinia bonduc (Caesalpinia bonducella) -- Cannabis sativa -- Capparis spinosa -- Cardiospermum halicacabum -- Carthamus tinctorius -- Carum carvi -- Cassia fistula -- Catharanthus roseus -- Celastrus paniculatus -- Centaurea behen -- Centella asiatica -- Chamaecrista absus (Cassia absus) -- Chamaemelum nobile (Anthemis nobilis) -- Cheilocostus speciosus (Costus Speciosus) -- Cichorium intybus -- Cinnamomum camphora -- Cinnamomum cassia -- Cinnamomum verum (C. zeylanicum) -- Citrullus colocynthis -- Clitoria ternatea -- Colchicum autumnale -- Colchicum luteum -- Commiphora gileadensis (C. opobalsamum) -- Commiphora myrrha -- Commiphora wightii (C. mukul) -- Convolvulus scammonia -- Cotoneaster nummularius -- Crocus sativus -- Croton tiglium -- Cullen corylifolium (Psoralea corylifolia) -- Cuminum cyminum -- Curcuma aromatica -- Curcuma longa -- Curcuma zedoaria -- Cuscuta chinensis -- Cuscuta reflexa -- Cydonia oblonga -- Cymbopogon schoenanthus -- Cyperus rotundus -- Datura stramonium -- Delphinium denudatum -- Dolichousnea longissimi (Usnea longissima) -- Doronicum pardalianches -- Embelia ribes -- Euphorbia hirta -- Euphorbia resinifera -- Ferula assa-foetida -- Ficus carica -- Ficus racemosa -- Foeniculum vulgare -- Fumaria officinalis -- Gentiana lutea -- Glycyrrhiza glabra -- Gymnema sylvestre -- Helleborus niger -- Hemidesmus Indicus -- Hibiscus rosa-sinensis -- Holarrhena pubescens (Holarrhena antidysenterica) -- Hyoscyamus niger -- Hyssopus officinalis -- Illicium verum -- Iris germanica -- Juniperus communi -- Justicia adhatoda (Adhatoda vasica) -- Lactuca sativa -- Lavandula stoechas -- Lawsonia inermis -- Lepidium sativum -- Linum usitatissimum -- Lupinus albus -- Malva sylvestris -- Marrubium vulgare -- Matricaria chamomilla -- Melia azedarach -- Melilotus officinalis -- Melissa officinalis -- Mesua ferrea -- Momordica charantia -- Moringa oleifera -- Myristica fragrans -- Myrtus communis -- Nageia nagi -- Nepeta cataria -- Nigella sativa -- Ocimum basilicum -- Ocimum gratissimum -- Ocimum tenuiflorum (Ocimum sanctum -- Operculina turpethum -- Paeonia emodi -- Pandanus odorifer (Pandanus Odoratissimus) -- Papaver somniferum -- Persicaria bistorta -- Phyllanthus emblica (Emblica officinalis) -- Picrorhiza kurroa -- Pimpinella anisum -- Piper cubeba -- Piper nigrum -- Pistacia lentiscus -- Plantago major -- Plantago ovata -- Plumbago zeylanica -- Polygonum aviculare -- Portulaca oleracea -- Quercus infectoria -- Rauvolfia serpentina -- Rheum emodi -- Rheum officinale -- Ricinus communis -- Rubia cordifolia -- Rumex vesicarius -- Ruta graveolens -- Salix caprea -- Salvia officinalis -- Santalum album -- Saussurea lappa -- Semecarpus anacardium -- Senna alexandrina -- Senna occidentalis -- Senna tora -- Sida cordifolia -- Smilax china;- Solanum americanum (S. nigrum) -- Sterculia urens -- Strychnos nux-vomica -- Swertia chirata -- Symplocos racemosa -- Syzygium cumini (Eugenia jambolana) -- Tamarindus indica -- Taraxacum officinale -- Taxus baccata -- Tephrosia purpurea -- Terminalia bellirica -- Terminalia chebula -- Thymus vulgaris -- Tinospora cordifolia -- Trachyspermum ammi (Ptychotis coptica) -- Tribulus terrestris -- Trigonella foenum-graecum -- Tussilago farfara -- Valeriana jatamansi (Nardostachys jatamansi) -- Verbena officinalis -- Vernonia anthelmintica (Baccharoides anthelmintica) -- Vigna unguiculata (Dolichos biflorus) -- Viola odorata -- Viscum album -- Withania somnifera -- Wrightia tinctoria -- Zingiber officinale -- Zingiber zerumbet -- Ziziphus jujuba -- Abbreviations -- Glossary -- Ayurvedic Terms of Diseases -- List of Referenced Books -- Index.

Kurzfassung: This book is designed to provide pharmacologists and researchers of natural products a comprehensive review of 200 medicinal plants, their vernacular names in various languages and their medicinal uses around the world, and in some cases, a historical perspective. Chemical constituents of each plant with the putative active constituent, and available up to date pharmacological studies (until 2017 on PubMed) with each medical activity explored and its relationship with traditional uses, are described for each plant. Any variations in chemical constituents and their effects on pharmacological studies outcome have been highlighted. All clinical trials conducted, with sufficient details, have been included. Nationalities and racial identities of participants of clinical trials are identified to impress upon the social, cultural and dietary influences on the clinical outcomes. Toxicity studies and potential interactions with prescribed drugs, and full spectrum of references are included.

Materialart: Online-Ressource

Seiten: XXX, 2156 p. 199 illus., 198 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030168070

URL: https://doi.org/10.1007/978-3-030-16807-0

DOI: 10.1007/978-3-030-16807-0

DDC: 615

Sprache: Englisch

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Approaching Complex Diseases : Network-Based Pharmacology and Systems Approach in Bio-Medicine (2020)

Bizzarri, Mariano. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Bioinformatics. ; Oncology. ; Medicine Philosophy. ; Pharmacology. ; Computational and Systems Biology. ; Oncology. ; Philosophy of Medicine.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Revisiting the concept of human disease (Mariano Bizzarri, Mirko Minini, and Noemi Monti) -- Chapter 2. Dynamical aspects of pharmacokinetic/pharmacodynamics and quantitative systems pharmacology models (Ioannis Loisios-Konstantinidis, Panteleimon D. Mavroudis, Panos Macheras) -- Chapter 3. The efficiency of multi-target drugs: a network approach (Lucas N. Alberca, Alan Talevi) -- Chapter 4. Mining Complex Biomedical Literature for Actionable Knowledge on Rare Diseases (Vinicius M. Alvesa, Stephen J. Capuzzia, Nancy Baker, Eugene N. Muratov, Alexander Trospsha, and Anthony J. Hickey) -- Chapter 5. Big Data, Personalized Medicine and Network Pharmacology: beyond the current paradigms (Alessandro Giuliani and Virginia Todde) -- Chapter 6. Epigenetic Control Using Small Molecules in Cancer (Tomohiro Kozako, Yukihiro Itoh, Shinichiro Honda, Takayoshi Suzuki) -- Chapter 7. Multiscale Modelling of Cancer: Micro-, Meso- and Macro-scales of Growth and Spread (Mark AJ Chaplain) -- Chapter 8. Precision Oncology vs Phenotypic approaches in the management of cancer: a case for the postmitotic state (Armando Aranda-Anzaldo and Myrna A.R. Dent) -- Chapter 9. Migrastatics - anti-metastatic drugs targeting cancer cell invasion (Aneta Gandalovičová , Daniel Rosel , Jan Brábek) -- Chapter 10. Critical steps in Epithelial-Mesenchymal transition as target for cancer treatment (Evgeny V. Denisov, Mohit Kumar Jolly, Vitaly P. Shubin, Alexey S. Tsukanov, Nadezhda V. Cherdyntseva) -- Chapter 11. Targeting the tumor-associated macrophages for ‘normalizing’ cancer (Julia Kzhyshkowska) -- Chapter 12. Tumor Reversion induced by embryo and oocyte extracts (Sara Proietti, Andrea Pensotti and Alessandra Cucina) -- Chapter 13. Trabectedin, a drug acting on both cancer cells and the tumor microenvironment (Paola Allavena, Manuela Liguori, Cristina Belgiovine) -- Chapter 14. Advances in Characterizing Recently-identified Molecular Actions of Melatonin: Clinical Implications (Russel J. Reiter, Ramaswamy Sharma, Sergio A. Rosales-Corral, Ana Coto-Montes, Jose Antonio Boga, Jerry Vriend) -- Chapter 15. Multitarget activities of Inositol and Inositol Hexakisphosphate (Ivana Vucenik) -- Chapter 16. Integration of Phytochemicals and Phytotherapy into Cancer Precision Medicine (Nadire Özenver and Thomas Efferth) -- Chapter 17. Synergistic Effects of Chinese Herbal Medicine and Biological Networks (Deep Jyoti Bhuyan, Saumya Perera1, Kirandeep Kaur, Muhammad A. Alsherbiny, Mitchell Low, Sai-Wang Seto, Chun-Guang Li, Xian Zhou) -- Chapter 18. Medicinal herbs: its therapeutic use in obstetrics and gynaecology (Irene Orbe, Daniel Paz, Leyre Pejenaute, Andrea Puente, Laura Diaz de Alda, Sandra Yague, Iñaki Lete) -- Chapter 19. Overcoming Antibiotic Resistance: New Perspectives (Matteo Bassetti, Elda Righi).

Kurzfassung: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.

Materialart: Online-Ressource

Seiten: XVI, 483 p. 49 illus., 41 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030328573

Serie: Human Perspectives in Health Sciences and Technology, 2

URL: https://doi.org/10.1007/978-3-030-32857-3

DOI: 10.1007/978-3-030-32857-3

DDC: 615

Sprache: Englisch

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New Nanomaterials and Techniques for Tumor-targeted Systems (2020)

Huang, Rongqin. [editor.] ; Wang, Yi. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Nanotechnology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Nanotechnology. ; Biomedical Research.

Beschreibung / Inhaltsverzeichnis: 1 Introduction -- 2 Barriers for tumor drug delivery -- 3 Tumor-targeted strategies -- 4 Tumor-responsive drug release strategies -- 5 Tumor diagnosis patterns -- 6 Tumor therapeutic modes -- 7 Carbon-based tumor-targeted systems -- 8 Silica-based tumor-targeted systems -- 9 Lipid-based tumor-targeted systems -- 10 Dendrimer-based tumor-targeted systems -- 11 Polymer-based tumor-targeted systems -- 12 Other new tumor-targeted systems -- 13 Clinical applications of tumor-targeted systems -- 14 Challenges and perspectives of tumor-targeted systems.

Kurzfassung: This book summarizes the latest advances in nanomaterials and techniques in the field of tumor-targeted diagnosis and therapy. It provides valuable information for beginners and senior researchers, and stimulates new research directions by offering novel and provocative insights into the properties and technical principles of nanomaterials. The book systemically discusses the challenges in tumor treatment, current tumor-targeted strategies, drug-release strategies, diagnosis and therapeutic patterns, and also explores newly developed multifunctional nanomaterials and related systems.

Materialart: Online-Ressource

Seiten: VI, 463 p. 72 illus., 63 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811551598

URL: https://doi.org/10.1007/978-981-15-5159-8

DOI: 10.1007/978-981-15-5159-8

DDC: 571.978

Sprache: Englisch

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Sunlight, Vitamin D and Skin Cancer (2020)

Reichrath, Jörg. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Dermatology. ; Oncology. ; Cancer Biology. ; Dermatology. ; Oncology.

Beschreibung / Inhaltsverzeichnis: Section I: Introduction -- Lessons learned from paleolithic models and evolution for human health: a snap shot on beneficial effects and risks of solar radiation -- Section II: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences (I) -- Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need? -- Section III: Solar radiation, Vitamin D and human health -- Vitamin D status and cancer incidence and mortality -- Vitamin D receptors polymorphisms and cancer -- On the relationship between sun exposure and all-cause mortality -- Lindqvist PG (2020) Women with greater sun exposure habits seem to be healthier and to live longer. Are these results in contrast to other research? No -- Section IV: Epidemiology of skin cancer -- Epidemiology of skin cancer and UV radiation – update 2019 -- Solar UV exposure and mortality from skin tumors: an update -- Solarium Use and Risk for Malignant Melanoma: many open questions,not the time to close the debate -- Section V: Photocarcinogenesis of skin cancer -- Molecular biology of basal and squamous cell carcinomas -- Human papillomaviruses and skin cancer -- The immune system and pathogenesis of melanoma and nonnmelanoma skin cancer -- Section VI: The relevance of the vitamin D endocrine system for skin cancer -- Protection from ultraviolet damage and photocarcinogenesis by vitamin D compounds -- The role of classical and novel forms of vitamin D in the pathogenesis and progression of non-melanoma skin cancers -- The Vitamin D Receptor as tumor suppressor in skin -- Cancer prevention in skin and other tissues via cross-talk between vitamin D- and p53- signalling -- Section VII: Prevention and Management of Skin Cancer -- Sunscreens in the United States: Current Status and Future Outlook -- A handful of sunscreen for whole body application -- Sunlight, vitamin D and Xeroderma pigmentosum -- Update: Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs) -- Section VIII: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences – II. promise and outlook -- Ultraviolet exposure scenarios: balancing risks of erythema and cutaneous vitamin D synthesis -- The Paleolithic nutrition model in relation to ultraviolet light and vitamin D -- Index.

Kurzfassung: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‑exposure to minimize the risks of developing vitamin D deficiency and skin cancer.

Materialart: Online-Ressource

Seiten: XIV, 428 p. 83 illus., 28 illus. in color. , online resource.

Ausgabe: 3rd ed. 2020.

ISBN: 9783030462277

Serie: Advances in Experimental Medicine and Biology, 1268

URL: https://doi.org/10.1007/978-3-030-46227-7

DOI: 10.1007/978-3-030-46227-7

DDC: 571.978

Sprache: Englisch

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Cancer Stem Cells: New Horizons in Cancer Therapies (2020)

Pathak, Surajit. [editor.] ; Banerjee, Antara. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Stem cells. ; Oncology. ; Medical microbiology. ; Cancer Biology. ; Stem Cell Biology. ; Oncology. ; Medical Microbiology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction to cancer stem cells -- Chapter 2. Types of Cancer Stem Cells -- Chapter 3. Isolation and Characterization of Cancer Stem Cells (CSCs) -- Chapter 4. Lung and Prostate Cancer Stem Cells -- Chapter 5. A differential role of miRNAs in regulation of breast cancer stem cells -- Chapter 6. Skin stem cells in cancer -- Chapter 7. Ocular Cancer stem cells: Advances in therapeutic interventions -- Chapter 8. Cancer Stem Cells and Tumour Aggressiveness -- Chapter 9. Therapeutic Implication of Cancer Stem Cells.-Chapter 10. Glioblastoma stem cells as a therapeutic target -- Chapter 11. Cancer stem cells and therapeutic angiogenesis -- Chapter 12. Cancer stem cells as a seed for cancer metastasis -- Chapter 13. Functionality of intron specific genes and cancer stem cells in the progression of colorectal cancer -- Chapter 14. Technological advancement in Cancer Stem Cell Research -- Chapter 15. Controversies in Isolation and Characterization of Cancer Stem Cells -- Chapter 16. Targeting therapies for cancer stem cells -- Chapter 17. Targeting Cancer stem cells by nanoenabled drug delivery -- Chapter 18. Cancer Stem Cells in Patients Survival and Therapies in Cancer.-.

Kurzfassung: This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.

Materialart: Online-Ressource

Seiten: VII, 369 p. 65 illus., 58 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811551208

URL: https://doi.org/10.1007/978-981-15-5120-8

DOI: 10.1007/978-981-15-5120-8

DDC: 571.978

Sprache: Englisch

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Pharmacology of Immunotherapeutic Drugs (2020)

Mathias, Clinton B. [editor.] ; McAleer, Jeremy P. [editor.] ; Szollosi, Doreen E. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Immunology. ; Pharmacology. ; Immunology.

Beschreibung / Inhaltsverzeichnis: Preface Chapter 1: Overview of the Immune System and its Pharmacological Targets -- Chapter 2: Modulation of the Innate Immune System -- Chapter 3: Modulation of the Adaptive Immune System -- Chapter 4: Respiratory Disorders of the Immune System and their Pharmacological Treatment -- Chapter 5: Inflammation of the Skin and its therapeutic topics -- Chapter 6: Inflammatory Diseases of the Gastrointestinal Tract and Pharmacological Treatments -- Chapter 7: Mechanisms of Autoimmunity and Pharmacologic Treatments -- Chapter 8: Transplantation: Immunologic Principles and Pharmacologic Agents -- Chapter 9: Immunopathogenesis, Immunization, and Treatment of Infectious Diseases -- Chapter 10: Cancer Immunotherapy.

Kurzfassung: Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are discussed in detail. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.

Materialart: Online-Ressource

Seiten: XIX, 399 p. 118 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030199227

URL: https://doi.org/10.1007/978-3-030-19922-7

DOI: 10.1007/978-3-030-19922-7

DDC: 615

Sprache: Englisch

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Tumor Microenvironment : State of the Science (2020)

Birbrair, Alexander. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Biomechanics. ; Cancer Biology. ; Biomechanics.

Beschreibung / Inhaltsverzeichnis: Metabolism in the tumor microenvironment -- Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment -- Viral hepatitis, inflammation, and tumour microenvironment -- Effects of HIV on the tumor microenvironment -- GLI2-mediated inflammation in the tumor microenvironment -- Stellate Cells in the Tumor Microenvironment -- Endothelial Progenitors in the Tumor microenvironment -- Chimeric antigen receptors for the tumour microenvironment -- Toll-Like Receptors (TLRs) in the Tumor Microenvironment (TME): A dragon-Like Weapon in a Non-Fantasy Game of Thrones -- Multiple dynamics in tumor microenvironment under radiotherapy -- Index.

Kurzfassung: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research in the field. A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more. Taken alongside its companion volumes, Tumor Microenvironment: State of the Science updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Materialart: Online-Ressource

Seiten: XIII, 208 p. 28 illus., 26 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030445188

Serie: Advances in Experimental Medicine and Biology, 1263

URL: https://doi.org/10.1007/978-3-030-44518-8

DOI: 10.1007/978-3-030-44518-8

DDC: 571.978

Sprache: Englisch

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Rabies and Rabies Vaccines (2020)

Ertl, Hildegund C.J. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Virology. ; Immunology. ; Pharmacology. ; Virology. ; Immunology.

Beschreibung / Inhaltsverzeichnis: Rabies Life Cycle, Transmission and Pathogenesis -- History of Rabies and Rabies Vaccines -- Rabies vaccines for wildlife -- Human Rabies Vaccines -- Rabies vaccines, prophylactic, Peru -- Rabies Prevention in Asia: Institutionalizing Implementation Capacities -- Passive Immunity in Rabies Prophylaxis -- Rabies Little Virus Against Powerful Innate Immunity -- Novel Rabies Vaccines -- Assessing the potency of inactivated veterinary vaccines and oral live vaccines against rabies -- WHO Perspective on Rabies.

Kurzfassung: This book reviews the recent advances in rabies research and rabies vaccine development. The reader is introduced to biology and pathology of the virus, causing agents and the history of rabies vaccination. The book presents regional rabies prophylaxis programs and discusses vaccination strategies for wildlife and humans. Further, innate immune response as well as antibody response to rabies are examined. All chapters are written by renowned experts in rabies research, some of them part of the WHO Collaboration Centre for Rabies Surveillance and Research. The book targets researchers and health professionals working in Virology, Veterinary Medicine and Biomedicine. .

Materialart: Online-Ressource

Seiten: VII, 205 p. 15 illus., 12 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030210847

URL: https://doi.org/10.1007/978-3-030-21084-7

DOI: 10.1007/978-3-030-21084-7

DDC: 615

Sprache: Englisch

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Principles of Forensic Toxicology (2020)

Levine, Barry S. [editor.] ; KERRIGAN, SARAH. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Forensic sciences. ; Medical jurisprudence. ; Pharmacology. ; Forensic Science. ; Forensic Medicine.

Beschreibung / Inhaltsverzeichnis: Part 1: Introduction -- Post Mortem Forensic Toxicology -- Human Performance Toxicology -- Drug-Facilitated Sexual Assault -- Forensic Drug Testing -- Performance enhancing Drug Testing -- Drug Testing in Pain Management -- Pharmacokinetics and Pharmacodynamics -- Part II. Specimen Preparation -- Spectrophotometry -- Chromatography -- Derivatization -- Immunoassy -- Mass Spectrometry -- Quantitation -- Method Validation -- Measurement Uncertainty and Traceability -- Statistics in Forensic Toxicology -- Part III Analytes -- Alcohol -- Benzodiazapines -- Gammahydroxybutyric acid,- Miscellaneous Central Nervous System Depressants -- Opioids -- Cocanie -- Cannabis -- Amphetamines-Sympathomimetic Amines,- Hallucinogens and Psychedelics -- Antidepressants and Neuroleptics -- Miscellaneous Therapeutic Drugs -- Carbon Monoxide/Cyanide -- Inhalants -- Metals -- Part III Special Topics -- Stability of Drugs of Abuse in Biological Systems -- Postmortem Redistribution of Drugs -- Postmortem Clinical Testing -- Pharmacogenomics -- Hair Drug Testing -- Oral Fluid Testing -- Meconium Drug Testing -- Drugs in Embalmed Tissues.

Kurzfassung: The fifth edition of the best-selling Principles in Forensic Toxicology continues in the tradition of excellence in academic publishing. With over 10 years of classroom-tested and continually updated content, the new edition contains significant updates and 7 new chapters on new topics including drug-facilitated crimes, derivatization, quantitation, measurement uncertainty/traceability, statistics, oral fluid testing, and drugs in embalmed specimens. Part One covers the major sub-disciplines of forensic toxicology in addition to pharmacological concepts. Part Two addresses specimen preparation, laboratory testing and instrumental analysis, while Part Three discusses common analytes including cocaine, opioids, alcohol, and marijuana. Adopted for courses in many of the top universities for forensic science and used by respected medical examiner’s offices and crime laboratories worldwide, Principles of Forensic Toxicology prepares the next generation of forensic toxicologists and continues to be an important reference in professional practice.

Materialart: Online-Ressource

Seiten: XIII, 691 p. 188 illus., 23 illus. in color. , online resource.

Ausgabe: 5th ed. 2020.

ISBN: 9783030429171

URL: https://doi.org/10.1007/978-3-030-42917-1

DOI: 10.1007/978-3-030-42917-1

DDC: 615

Sprache: Englisch

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Tumor Microenvironment : Recent Advances (2020)

Birbrair, Alexander. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.

Beschreibung / Inhaltsverzeichnis: Novel techniques to study the bone-tumor microenvironment -- An emerging model for cancer development from a tumor -- microenvironment perspective in mice and humans -- Effects of Exercise on the Tumour Microenvironment -- Effects of inhaled tobacco smoke on the pulmonary tumor microenvironment -- Multimodal molecular imaging of the tumour microenvironment -- Necrosis in the tumor microenvironment and its role in cancer recurrence -- The Multifaceted Effects of Autophagy on the Tumor Microenvironment -- The Sociobiology of Brain Tumors -- Tumor microenvironment conditioning by abortive lytic replication of oncogenic γ-herpesviruses -- The microbiome as a component of the tumor microenvironment -- Index.

Kurzfassung: This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment. Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.

Materialart: Online-Ressource

Seiten: XI, 160 p. 31 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030357276

Serie: Advances in Experimental Medicine and Biology, 1225

URL: https://doi.org/10.1007/978-3-030-35727-6

DOI: 10.1007/978-3-030-35727-6

DDC: 571.978

Sprache: Englisch

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Tumor Microenvironment : Non-Hematopoietic Cells (2020)

Birbrair, Alexander. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.

Beschreibung / Inhaltsverzeichnis: Adipocytes in the tumour microenvironment -- Fibroblasts in the tumor microenvironment -- Mesenchymal stem cells in the tumor microenvironment -- Hepatic stellate cells in liver tumor -- Pancreatic stellate cells: The key orchestrator of the pancreatic tumor microenvironment -- Endothelial cells in the tumor microenvironment -- Lymphatic endothelial cell progenitors in the tumor microenvironment -- Oligodendrocyte progenitors in the tumor microenvironment -- Index.

Kurzfassung: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor microenvironment.Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include fibroblasts, adipocytes, mesenchymal stem cells, stellate cells, and more. Taken alongside its companion volumes, Tumor Microenvironment: Non-Hematopoietic Cells updates us on what we know about the different aspects of the tumor microenvironment as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists focused in the tumor microenvironment and how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment. All of the chapter authors are renowned international experts in the cancer biology field in specific subfields that will be the focus of their chapters.

Materialart: Online-Ressource

Seiten: X, 129 p. 31 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030371845

Serie: Advances in Experimental Medicine and Biology, 1234

URL: https://doi.org/10.1007/978-3-030-37184-5

DOI: 10.1007/978-3-030-37184-5

DDC: 571.978

Sprache: Englisch

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'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine (2020)

Masood, Nosheen. [editor.] ; Shakil Malik, Saima. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Oncology. ; Medical genetics. ; Bioinformatics. ; Microtechnology. ; Microelectromechanical systems. ; Cancer Biology. ; Oncology. ; Medical Genetics. ; Bioinformatics. ; Microsystems and MEMS.

Beschreibung / Inhaltsverzeichnis: Module 1_ Introduction -- Module 2_ Cancer Metastasis -- Module 3_ Role of Transcriptomics in cancer treatment strategies -- Module 4_Computational approaches -- Module 5_Biostatistics and clinical oncology -- Module 6_Pharmacogenomics in cancer -- Chapter 7_Case studies.

Kurzfassung: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Materialart: Online-Ressource

Seiten: XVIII, 499 p. 59 illus., 50 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811510670

URL: https://doi.org/10.1007/978-981-15-1067-0

DOI: 10.1007/978-981-15-1067-0

DDC: 571.978

Sprache: Englisch

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Diseases of the Breast during Pregnancy and Lactation (2020)

Alipour, Sadaf. [editor.] ; Omranipour, Ramesh. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Human physiology. ; Medicine Research. ; Biology Research. ; Gynecology . ; Cancer Biology. ; Human Physiology. ; Biomedical Research. ; Gynecology.

Beschreibung / Inhaltsverzeichnis: Preface -- PART 1: Basic Considerations -- Anatomy and Physiology of the Breast during Pregnancy and Lactation -- Diagnosis of Breast Disorders in Pregnancy and Lactation -- Clinical Presentations of Breast Disorders in Pregnancy and Lactation -- PART 2: Benign and Premalignant Disorders of the Breast in Pregnancy and Lactation -- Benign Disorders of the Breast in Pregnancy and Lactation -- Mastitis, Breast Abscess, and Granulomatous -- Premalignant disorders of the Breast in Pregnancy and Lactation -- PART 3: Breast Cancer in Pregnancy and Lactation -- Epidemiology of Pregnancy-Associated Breast Cancer -- Histology of Pregnancy-Associated Breast Cancer -- Clinical presentation, Diagnosis, and Prognosis of Pregnancy-Associated Breast Cancer -- . Treatment of Pregnancy-Associated Breast Cancer -- Special Clinical Situations -- Prenatal Care during and after Breast Cancer Treatment -- Lactation during and after Breast Cancer -- Pregnancy in Breast Cancer Survivors. Impact of Breast Cancer Treatment on Fertility -- Fertility Counseling and Preservation for Breast Cancer Patients -- Pregnancy after Breast Reconstruction -- Pregnancy and Lactation: Risk or Protective Factors for Breast Cancer -- Psychological Aspects of Pregnancy and Lactation in Patients with Breast Cancer.

Kurzfassung: Symptoms of the breast in gravid women commonly represent physiological changes, however they may also be related to serious underlying breast disease; this challenging dilemma is aggravated by diagnostic and therapeutic limitations imposed by safety issues regarding the mother and fetus. A comprehensive coverage of all aspects of normal and pathologic breast changes during pregnancy and lactation, their diagnosis and management is provided in the present work. The organized structure of this book begins with gestational changes of the breast, while discussing safety, hazards, and arguments regarding diagnostic approaches. It then goes on by describing various clinical presentations and common and uncommon benign disorders during gravidity. The book then addresses pre-malignant lesions of the breast, opening the dialogue on how to manage these confusing lesions in pregnant and nursing women. It continues toward pregnancy-associated breast cancer, focusing on every facet of the problem, including epidemiology, diagnosis, treatment and complications, anesthetic considerations, prenatal care, and rare malignancies; and comes to an end by arguing main psychological concerns. In the midst of this orderly sequence fertility issues, pregnancy, and breastfeeding in women who have overcome their breast cancer are also discussed. This unique reference has been written by academic experts from different centers and diverse disciplines in a practical format. It is intended to be an ideal resource for every practitioner and specialist who manages complaints of gravid and nursing women or treats breast disorders in women of child bearing age.

Materialart: Online-Ressource

Seiten: XXV, 216 p. 55 illus., 38 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030415969

Serie: Advances in Experimental Medicine and Biology, 1252

URL: https://doi.org/10.1007/978-3-030-41596-9

DOI: 10.1007/978-3-030-41596-9

DDC: 571.978

Sprache: Englisch

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Tumor Microenvironment : Extracellular Matrix Components – Part B (2020)

Birbrair, Alexander. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Stem cells. ; Regenerative medicine. ; Cytology. ; Cancer Microenvironment. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Cell Biology.

Beschreibung / Inhaltsverzeichnis: Elastin in the Tumor Microenvironment -- Decorin in the tumor microenvironment -- Syndecan-1 in the tumor microenvironment -- Versican in the tumor microenvironment -- Chondroitin Sulphate Proteoglycans in the Tumour Microenvironment -- Lipoproteins and the Tumor Microenvironment -- The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility -- Thrombospondin in Tumor Microenvironment -- Tenascin-C function in glioma: immunomodulation and beyond -- Index.

Kurzfassung: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor microenvironment during cancer development. Furthermore, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include elastin, decorin, syndecan-1, versican, lipoproteins, brevican, thrombospondin, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part B updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapters authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Materialart: Online-Ressource

Seiten: XIII, 178 p. 36 illus., 33 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030484576

Serie: Advances in Experimental Medicine and Biology, 1272

URL: https://doi.org/10.1007/978-3-030-48457-6

DOI: 10.1007/978-3-030-48457-6

DDC: 571.978

Sprache: Englisch

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Contract Research and Development Organizations-Their History, Selection, and Utilization (2020)

Gad, Shayne C. ; Spainhour, Charles B. ; Serota, David G.

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Pharmacy. ; Pharmacology. ; Pharmacy.

Beschreibung / Inhaltsverzeichnis: Introduction -- History of CROs: Including CRO Snapshots and a CRO Genealogy Chart -- The Pharmaceutical Development Process & Testing Requirements -- The Medical Device Development Process & Testing Requirements -- Functions and Types of CROs -- Labs in China and India -- Selection of CROs -- Study Directors and PIs -- Nuts and Bolts of Study Performance SCG/CBS -- Electronic Reporting Requirements (SEND & eCTD) -- Study and Project Monitoring -- Contracting, Pricing, and Cost of Works Performed by CROs -- Consultants and their Role -- Building Relationships: Maximizing your return on Expectations with a CRO -- Common Problems and their Solutions -- Appendices: A Toxicology Labs B Medical Device Labs C Phase I Labs D Analytical Labs E GMP Contract Facilities F Formulation G Dosage Forms H Clinical Testing I Regulatory Services J Forms and Checklists -- K Specialized Services -- L Consultants Known to be In-Practice -- Index. .

Kurzfassung: This volume provides a complete update of all the materials in prior volumes on the subject (including current directories to testing labs and other support establishments worldwide), while adding substantial new material on the following topics: · The history of CROs, including snapshots of CROs and a genealogy chart making clear where they came from and where they went. · Study directors and principal investigators. · The nuts and bolts of study performance. · Electronic reporting requirements – SEND and eCTD (required for NDA, BLA, ANDA, and IND submissions). · Consultants and their roles. · An expanded examination of common problems and their solutions. This book boasts complete directories to the global universe of operating labs – where they are, how to contact them, and what they do (including special capabilities). Additionally, checklists for qualifying labs and manufacturing facilities – and for auditing studies and projects at such facilities – are included. It is directed at those in industry (specifically directed at those working for companies using CRO services) but will also be of interest to scientists or administrators working in research organizations themselves. In this case, the contents of this new work are essential to the target reader because the work, regulations, and actors (CROs) have evolved and changed at a rapid pace in the 10 years since the earlier volume that the author published. Likewise, the companies using these services have come to all be almost completely dependent on outsourcing. The earlier texts remain the only source of their kind (paper or electronic) on the field and the only noncommercial guide to the global industry and this volume provides a complete update.

Materialart: Online-Ressource

Seiten: XIII, 519 p. 19 illus., 1 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030430733

URL: https://doi.org/10.1007/978-3-030-43073-3

DOI: 10.1007/978-3-030-43073-3

DDC: 615

Sprache: Englisch

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Immunotherapy (2020)

Naing, Aung. [editor.] ; Hajjar, Joud. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Immunology. ; Oncology. ; Cancer Biology. ; Immunology. ; Oncology.

Beschreibung / Inhaltsverzeichnis: Overview of Basic Immunology and Clinical Application -- Advances in Diagnostic Procedures and their Applications in the era of Cancer Immunotherapy -- Immunotherapy for Melanoma -- Immunotherapy in Lung Cancer: From a minor God to the Olympus -- Immunotherapy in Gastrointestinal Malignancies -- Current Landscape of Immunotherapy in Genitourinary Malignancies -- Immuno-oncology for Gynecologic Malignancies -- Immunotherapy for Neuro-Oncology -- Immunotherapy and Radiation -- CAR T-cells -- Skin Reactions to Immune Checkpoint Inhibitors -- Gastrointestinal Tract Adverse Events -- Immune-Related Adverse Events: Pneumonitis -- Hepatobiliary Adverse Events -- Immune Checkpoint Inhibitors (ICIs) Related Cardiotoxicity -- Renal Toxicity -- Immune-Related Oral, Otologic and Ocular Adverse Events -- Cancer Imaging in Immunotherapy -- The Microbiome in Immuno-Oncology -- New developments in the use of Patient-reported outcomes in Cancer Patients undergoing Immunotherapies.

Kurzfassung: Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. The third edition of Immunotherapy is an updated overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. It explores the breath of immunotherapeutic strategies available to treat a wide range of cancers, from melanoma and non-small cell lung cancer to gastrointestinal, genitourinary, gynecologic and nervous system malignancies. With increasing use of checkpoint inhibitors as standard of care and in clinical trials, the challenges associated with their use undoubtedly increase. As objective response is limited to a subset of patients and is often associated with distinct immune related side effects that are potentially life threatening, it is essential to identify patients who are likely to respond to immunotherapy and those who are at a risk for developing treatment-related side effects. In the absence of a validated predictive biomarker, innovative technologies and assays are being used to identify critical biomarkers that drive the immune response. Hence, a chapter to provide a basic understanding of the diagnostic procedures has been included besides the chapter on the cellular components of the human immune system. This new edition will also inform readers on use of novel microbiome and imaging approaches. Finally, the book includes a chapter on patient-reported outcomes in patients treated with immunotherapies as the authors recognize the importance of including missing patient voice in clinical trials and longitudinal assessment of symptom reports. In short, the third edition of this book provides a comprehensive overview of the latest developments in the field of immune-oncology that will help health care professionals make informed treatment decisions. The book’s chapters are written by a diverse cast of experts conducting cutting-edge research, providing the reader with the most up-to-date science.

Materialart: Online-Ressource

Seiten: XII, 339 p. 44 illus., 35 illus. in color. , online resource.

Ausgabe: 3rd ed. 2020.

ISBN: 9783030410087

Serie: Advances in Experimental Medicine and Biology, 1244

URL: https://doi.org/10.1007/978-3-030-41008-7

DOI: 10.1007/978-3-030-41008-7

DDC: 571.978

Sprache: Englisch

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Circulating Tumor Cells in Breast Cancer Metastatic Disease (2020)

Piñeiro, Roberto. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Stem cells. ; Cancer Biology. ; Biomedical Research. ; Biotechnology. ; Stem Cell Biology.

Beschreibung / Inhaltsverzeichnis: Preface -- Introduction – Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs -- Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis -- Disseminated Tumor Cells and Dormancy in Breast Cancer Progression -- Methodology for the Isolation and Analysis of CTCs -- Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-derived Models for Drug Testing -- Circulating Tumor Cells (CTCs) Heterogeneity in Metastatic Breast Cancer: Different Approaches for Different Needs -- Relevance of CTC Clusters in Breast Cancer Metastasis -- Epigenetics of Circulating Tumor Cells in Breast Cancer -- Circulating Tumor Cells: Applications for Early Breast Cancer -- Clinical Relevance and Therapeutic Application of CTCs in Advanced Breast Cancer. .

Kurzfassung: This book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients. This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine. The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer.

Materialart: Online-Ressource

Seiten: XV, 167 p. 15 illus., 14 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030358051

Serie: Advances in Experimental Medicine and Biology, 1220

URL: https://doi.org/10.1007/978-3-030-35805-1

DOI: 10.1007/978-3-030-35805-1

DDC: 571.978

Sprache: Englisch

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Novel therapeutic approaches for gastrointestinal malignancies (2020)

Nagaraju, Ganji Purnachandra. [editor.] ; Peela, Sujatha. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Nanotechnology. ; Radiology. ; Molecular genetics. ; Cancer Biology. ; Nanotechnology. ; Radiology. ; Molecular Genetics.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Role of selected transcription factors in pancreatic and colorectal cancer growth and metastasis -- Chapter 2. Adiponectin in gastrointestinal malignancies -- Chapter 3. Small molecule-targeted therapies for GI cancers: success and failures -- Chapter 4. Epigenetic biomarkers for the detection of Gastrointestinal Cancers -- Chapter 5. CD151: A Lateral organizer and modulator of Tumor microenvironment in gastrointestinal cancers -- Chapter 6. Targeting Pathways in GI Malignancies -- Chapter 7. Identification of Potential Key Genes Involved In Progression of Gastric Cancer Using Bioinformatics Analysis -- Chapter 8. Recent Development in the biomarkers for the gastric cancer -- Chapter 9. Gastric Cancer and it’s remedy -- Chapter 10. An intergenic variant rs4779584 between SCG5 and GREM1 contributes to the increased risk of colorectal cancer: A meta-analysis -- Chapter 11. Phytochemicals plus nanomaterial’s on colorectal cancer -- Chapter 12. Pancreatic Ductal Adenocarcinoma and Type 2 Diabetes Mellitus: Distant Relatives or the Close Ones? -- Chapter 13. Tumor Biomarkers and Diagnosis of Pancreatic Adenocarcinoma -- Chapter 14. Immunotherapy in Gastrointestinal Malignancies -- Chapter 15. The Role of HIF-1α in Hepatocellular Carcinoma.

Kurzfassung: This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.

Materialart: Online-Ressource

Seiten: XII, 259 p. 53 illus., 39 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811554711

Serie: Diagnostics and Therapeutic Advances in GI Malignancies,

URL: https://doi.org/10.1007/978-981-15-5471-1

DOI: 10.1007/978-981-15-5471-1

DDC: 571.978

Sprache: Englisch

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Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine (2020)

Jabbari, Bahman. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Surgery. ; Dentistry. ; Veterinary medicine. ; Neurology . ; Orthopedic surgery. ; Pharmacology. ; Surgery. ; Dentistry. ; Veterinary Science. ; Neurology. ; Surgical Orthopedics.

Beschreibung / Inhaltsverzeichnis: 1. History of development of botulinum toxin therapy in medical and surgical fields -- 2. Molecular structure and mechanisms of action of botulinum toxins as it pertains to clinical symptoms -- 3. Types of toxins in commercial use, their similarities and differences -- 4. A review of current Botulinum toxin treatment indications in medical field. - 5. Mechanisms of Analgesic effects of botulinum neurotoxins -- 6. Botulinum toxin treatment in Head and neck surgery -- 7. Botulinum toxin treatment of thoracic and abdominal surgery -- 8. Botulinum Toxin A in Abdominal Wall Reconstruction -- 9. Use of Botulinum toxin A in post-mastectomy breast reconstruction -- 10. Botulinum Toxins for Treatment of Pain in Orthopedic Disorders -- 11. Botulinum toxin for pediatric patients, Who? For what? When? -- 12. Botulinum Toxin Treatment in Plastic Surgery -- 13. Botulinum Toxin Treatment in Ophthalmology and Ophthalmic surgery -- 14. Botulinum Toxin Treatment in Gastrointestinal Disorders -- 15. Botulinum Toxin Treatment in Urological Disorders -- 16. Botulinum Toxin Treatment in Dentistry -- 17. Botulinum toxin treatment in Veterinary Medicine - Clinical implications -- 18. Future Perspectives of Botulinum Toxin Application In Dentistry.

Kurzfassung: All books on the market which have been written on the subject of botulinum toxin therapy focus on treatment of hyperactive movement disorders, autonomic dysfunction (bladder, sweat and salivary glands) and some pain indications (migraine). Reference to pre-or post -surgical indications are brief and often out-dated. No book has information on dentistry or veterinary medicine. This book provides up-to-date information on botulinum toxin therapy in surgical fields. It is also the only book in the market that provides information on botulinum toxin therapy in dentistry and veterinary medicine and furnishes the latest information. Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine appeals to many disciplines including surgery, dentistry and veterinary medicines well as appealing to neurologists and internists.

Materialart: Online-Ressource

Seiten: VIII, 398 p. 70 illus., 60 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030506919

URL: https://doi.org/10.1007/978-3-030-50691-9

DOI: 10.1007/978-3-030-50691-9

DDC: 615

Sprache: Englisch

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Nanoformulations in Human Health : Challenges and Approaches (2020)

Talegaonkar, Sushama. [editor.] ; Rai, Mahendra. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Therapeutics. ; Pharmacology. ; Therapeutics.

Beschreibung / Inhaltsverzeichnis: Nano-technological Platforms and Manipulations for the Emerging Ocular Manifestations -- Phytonanomedicines as Topical Alternatives for the Treatment of Skin Cancer -- Nano-sized Labile and Particulate Ingredients in Topical Formulations: A Strategic Approach Against Photoageing and Photocarcinogenisis -- Application of Biocompatible Nanocarriers in Glaucoma: Challenges and Advances -- Nano-carriers for Natural Therapeutics in the Management of Neuropathic Pain -- Advances in the Delivery of Therapeutic Peptides -- Nanoformulations and Their Role in Colon Targeting -- Theranostic Nanoformulations: Merging Diagnostics and Therapeutics -- The Role of Nanoformulations in Nose-To-Brain Drug Delivery -- Cubic Lyotropic Liquid Crystalline Nanostructures: A Versatile Platform for Delivery -- Preformulation Challenges: The Concept Behind the Selection, Design, and Preparation of Nanoformulations -- Nanoethosomes for Topical Fungal Therapeutics -- Comparison of Therapeutic Efficiency of Nanoformulations of Curcumin vs. Tetrahydrocurcumin in Various Disorders -- Nanomedicinal Approaches of Phytotherapeutics to Treat Alzheimers Disease -- Nanoparticulate Approaches to Exploit the Pathophysiology of Rheumatoid and Osteoarthritis -- Emerging Nanotechnology in Chronic Respiratory Diseases -- Conventional and Non-conventional Approaches of Site-specific Targeting of Therapeutics in Some Infectious Diseases and Metabolic Disorders -- Nanoformulations in Human Health Conditions: The Paradigm Shift -- Magnetic Nanoparticles Nanoformulation for Alternative Therapy of Cancer by Super-paramagnetic Hyperthermia -- Nano-weapons Against Tuberculosis -- Drug-Excipient Interactions in Nanoformulations with Special Focus on Impurity Control per ICH guidelines.

Kurzfassung: This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers, etc. The most important aspect of the book covers various types of nanoformulations and their applications in the treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, cancer, arthritis and tuberculosis.

Materialart: Online-Ressource

Seiten: XVIII, 548 p. 106 illus., 91 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030418588

URL: https://doi.org/10.1007/978-3-030-41858-8

DOI: 10.1007/978-3-030-41858-8

DDC: 615

Sprache: Englisch

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Hormonal Pathology of the Uterus (2020)

Deligdisch-Schor, Liane. [editor.] ; Mareş Miceli, Angelica. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Endocrinology. ; Pathology. ; Cancer Biology. ; Endocrinology. ; Pathology.

Beschreibung / Inhaltsverzeichnis: 1. Biophysiology of the uterus: development, cyclic changes, menopause -- 2. Hormonal effects in reproductive technology (ovulation stimulation, in vitro fertilization) -- 3. Hormonal role and therapy in common benign uterine lesions: endometrial polyps, leiomyomas, adenomyosis -- 4. Endometrial hyperplasia; precancerous lesions of the endometrium. Hormone therapy -- 5. Endometrial Carcinoma. Endometriosis, Hormonal Role in Carcinogenesis. Hormonal Therapy -- 6. Menopausal Hormone Therapy. Contraceptives -- 7. Replacement hormone therapy for gender dysphoria and congenital sexual anomalies -- 8. Hormone therapy for endometrial neoplasia related to breast cancer therapy (Tamoxifen) -- 9. Endometrial histopatholigic changes in hormonal therapy (contraceptives, ovulation stimulation, hormone replacement therapy, hormonal antitumoral therapy).

Kurzfassung: Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of “natural” hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women’s health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women’s health. .

Materialart: Online-Ressource

Seiten: VIII, 185 p. 66 illus., 59 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030384746

Serie: Advances in Experimental Medicine and Biology, 1242

URL: https://doi.org/10.1007/978-3-030-38474-6

DOI: 10.1007/978-3-030-38474-6

DDC: 571.978

Sprache: Englisch

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Transformation Processes of Metals in Urban Road Dust : Implications for Stormwater Reuse (2020)

Jayarathne, Ayomi. ; Wijesiri, Buddhi. ; Egodawatta, Prasanna. ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Water. ; Hydrology. ; Engineering geology. ; Pollution. ; Water. ; Geoengineering.

Beschreibung / Inhaltsverzeichnis: Chapter 1: Metals in urban stormwater environments -- Chapter 2: Research design -- Chapter 3: Metal transformation and stormwater quality -- Chapter 4: Risk evaluation based on the metal transformation and bioavailability -- Chapter 5: Practical implications and recommendation for future research -- Appendices -- Index.

Kurzfassung: This book discusses the physicochemical changes (transformations) that metals deposited on urban road surfaces undergo during dry weather periods, in order to provide insights into their potential impacts on stormwater quality. Based on extensive field experiments, and laboratory and data analyses, it examines transformation characteristics of metals with respect to the particle size of road dust, antecedent dry days and land uses. Further, it proposes a new risk-assessment methodology, improving the original human health-risk indices based on the transformation characteristics and potential bioavailability of metals in order to evaluate the risks posed by metals in stormwater. This book is of interest to researchers and decision-makers developing appropriate pollution mitigation measures to enhance the quality of stormwater, targeting the effective reuse of stormwater in urban areas.

Materialart: Online-Ressource

Seiten: VI, 50 p. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811520785

Serie: SpringerBriefs in Water Science and Technology,

URL: https://doi.org/10.1007/978-981-15-2078-5

DOI: 10.1007/978-981-15-2078-5

DDC: 363.73

Sprache: Englisch

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Empty Buckets and Overflowing Pits : Urban Water and Sanitation Reforms in Sub-Saharan Africa – Acknowledging Decline, Preparing for the Unprecedented Wave of Demand (2020)

Werchota, Roland.

Cham :Springer International Publishing :

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Schlagwort(e): Pollution. ; Refuse and refuse disposal. ; Sociology, Urban. ; Economic policy. ; Developmental psychology. ; Medical sciences. ; Pollution. ; Waste Management/Waste Technology. ; Urban Sociology. ; Economic Policy. ; Developmental Psychology. ; Health Sciences.

Beschreibung / Inhaltsverzeichnis: Part 1: Urban Water and Sanitation (W+S) - Separating fiction from reality -- Chapter 1. Introduction to urban W+S in the developing world -- Chapter 2. Considerations for general W+S issues -- Chapter 3. Beyond the usual debate -- PART 2: Design and validation of the sector development model -- Chapter 4. An effective orientation and approach for development -- Chapter 5. What sector reforms in four countries teach us? -- Chapter 6. Reasons for the different reform outcomes in the four countries -- Part 3: At least full buckets and clear pits on the way forward -- Chapter 7. Ending the ‘urban W+S divide’ by serving the poor -- Chapter 8. Conclusions: The quintessence of W+S sector reforms in Sub-Saharan Africa -- Chapter 9. Recommendations: Guidance to master the coming wave of challenges.

Kurzfassung: This book provides a multi-level and multi-dimensional insight into urban water and sanitation development by analyzing sector reforms in Africa. With the recent events in mind - water shortages in Cape Town, widespread cholera in Haiti, mass-migration from low-income countries, etc. – it elaborates a pressing topic which is directly linked to the precarious living conditions of the urban poor in the developing countries. It is urgent to acknowledge the proposed findings and recommendations of the book which will help to improve the situation of potential refugees in their home countries with a realistic vision for the development of the most basic of all life supporting services. So many efforts to reverse the negative trend in water and sanitation development have failed or targets have been repeatedly missed by far without notable consequences for decision makers on different levels and institutions. It has unnecessarily consumed many young lives, contributed to keep billions in poverty until today and fostered discrimination of women. The knowledge gap and the confusion in the sector lined out in the book becomes evident when a national leader in a low-income country declares a state of emergency in urban water and sanitation while at the same time global monitoring publishes an access figure for urban water of over 90% for the same country. It is time to change this with an effective sector development concept for our partner countries and a more realistic discourse on global level. The book argues for a sweeping rethinking and combines extended local knowledge, lessons learned from history in advanced countries and thorough research on reforms in Francophone and Anglophone developing countries. This was possible because the writer was working in Sub-Saharan partner countries for almost 30 years as an integrated long term advisor in different sector institutions (ministry, regulator, financing basket and different sizes of utilities) and had the opportunity to cooperate closely with the main development partners. The reader has the opportunity to obtain a comprehensive understanding of how the sector works and sector institutions in low-income countries function and can discover the reasons behind success and failures of reforms. The book also covers issues which have a significant influence on urban water and sanitation development but are hardly the subject of discussions. It helps to make the shortcomings of the water and sanitation discourse more apparent and assist institutions to move beyond their present perceptions and agendas. All of this makes the book different from other literature about urban water and sanitation in the developing world.

Materialart: Online-Ressource

Seiten: XXII, 285 p. 24 illus., 3 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030313838

Serie: Springer Water,

URL: https://doi.org/10.1007/978-3-030-31383-8

DOI: 10.1007/978-3-030-31383-8

DDC: 363.73

Sprache: Englisch

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Technological and Modern Irrigation Environment in Egypt : Best Management Practices & Evaluation (2020)

Omran, El-Sayed E. [editor.] ; Negm, Abdelazim M. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pollution. ; Agriculture. ; Environmental management. ; Environment. ; Geographic information systems. ; Sustainability. ; Pollution. ; Agriculture. ; Environmental Management. ; Environmental Sciences. ; Geographical Information System. ; Sustainability.

Beschreibung / Inhaltsverzeichnis: An Overview of Modern Irrigation system in Egypt -- Irrigation: Water Resources, Types and Common Problems in Egypt -- Need for Irrigation System Evaluation -- Evolution of irrigation system, tools and Technologies -- Smart Sensing System for Precision Irrigation -- Development of Recent Information on Irrigation Technology and Management.

Kurzfassung: This book gathers contributions on modern irrigation environments in Egypt from an environmental and agricultural perspective. Written by leading experts in the field, it discusses a wide variety of modern irrigation problems. In the context of water resources management in Egypt, one fundamental problem is the gap between growing water demand and limited supply. As such, improving irrigation systems and providing farmers with better control over water are crucial to increasing productivity. The book presents state-of-the-art technologies and techniques that can be effectively used to address a range of problems in modern irrigation, as well as the latest research advances. Focusing on water sensing and information technologies, automated irrigation technologies, and improved irrigation efficiency. It brings together a team of experts who share their personal experiences, describe the various applications, present recent advances, and discuss possibilities for interdisciplinary collaboration and implementing the techniques covered.

Materialart: Online-Ressource

Seiten: X, 369 p. 66 illus., 45 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030303754

Serie: Springer Water,

URL: https://doi.org/10.1007/978-3-030-30375-4

DOI: 10.1007/978-3-030-30375-4

DDC: 363.73

Sprache: Englisch

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Water Quality Index Prediction Using Multiple Linear Fuzzy Regression Model : Case Study in Perak River, Malaysia (2020)

Karim, Samsul Ariffin Abdul. ; Kamsani, Nur Fatonah.

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Water. ; Hydrology. ; Computational intelligence. ; Pollution. ; Water. ; Computational Intelligence.

Beschreibung / Inhaltsverzeichnis: Introduction -- Fuzzy Multiple Linear Regression -- Water Quality Index (WQI) -- Data Collection and Study Sites -- Water Quality Index Using Fuzzy Regression.

Kurzfassung: This book addresses the prediction of the Water Quality Index (WQI) at Perak River, State of Perak, Malaysia, using a fuzzy multiple linear regression model to tackle the uncertainty in the measurements of six key parameters – dissolved oxygen (DO), biological oxygen demand (BOD), chemical oxygen demand (COD), suspended solids (SS), pH value (pH) and ammoniacal nitrogen (NH3-NL). Given its scope, the book is suitable for graduate students, researchers and water quality scientists.

Materialart: Online-Ressource

Seiten: XII, 55 p. 18 illus., 16 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811534850

Serie: SpringerBriefs in Water Science and Technology,

URL: https://doi.org/10.1007/978-981-15-3485-0

DOI: 10.1007/978-981-15-3485-0

DDC: 363.73

Sprache: Englisch

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Microbial Bioremediation & Biodegradation (2020)

Shah, Maulin P. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Environmental chemistry. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Environmental health. ; Pollution. ; Environmental Chemistry. ; Environmental Engineering/Biotechnology. ; Environmental Health.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Bioremediation Approaches for Treatment of Pulp and Paper Industry Wastewater: Recent Advances and Challenges -- Chapter 2. Microbial remediation of Heavy Metals -- Chapter 3. Dyes: Effect on the Environment and Biosphere and Their Remediation Constraints -- Chapter 4. Microbial Bioremediation and Biodegradation of Hydrocarbons, Heavy Metals, and Radioactive Wastes in Solids and Wastewaters -- Chapter 5. Advancement of Omics: Prospects for Bioremediation of Contaminated Soils -- Chapter 6. Microbial Biotransformation of Hexavalent Chromium [Cr(VI)] in Tannery Wastewater -- Chapter 7. Bioremediation: A Low-Cost and Clean-Green Technology for Environmental Management -- Chapter 8. Microbial Degradation of Pharmaceuticals and Personal Care Products from Wastewater -- Chapter 9. Extremophiles: A Powerful Choice for Bioremediation of Toxic Oxyanions -- Chapter 10. Conventional and Nonconventional Biodegradation Technologies for Agro-Industrial Liquid Waste Management -- Chapter 11. White Rot Fungi: Nature’s Scavenger -- Chapter 12. Nanobioremediation: An Emerging Approach for a Cleaner Environment -- Chapter 13. Bioelectrochemical System for Bioremediation and Energy Generation -- Chapter 14. Ligninolysis: Roles of Microbes and Their Extracellular Enzymes -- Chapter 15. Biosorption of Heavy Metals by Cyanobacteria: Potential of Live and Dead Cells in Bioremediation -- Chapter 16. Bioremediation of pharmaceuticals in water and wastewater -- Chapter 17. Bioremediation Of Saline Soil by Cyanobacteria -- Chapter 18. Advancement in Treatment Technologies of Biopharmaceutical Industrial Effluents.-Chapter 19. Marine Bacteria: A Storehouse of Novel Compounds for Biodegradation -- Chapter 20. Energy-Efficient Anaerobic Ammonia Removal: From Laboratory to Full-Scale Application -- Chapter 21. Microbial Degradation of Natural and Synthetic Rubbers.-.

Kurzfassung: Microbial or biological degradation has long been the subject of active concern, and the rapid expansion and growing sophistication of various industries in the last century has significantly increased the volume and complexity of toxic residues of wastes. These can be remediated by plants and microbes, either natural origin or adapted for a specific purpose, in a process known as bioremediation. The interest in microbial biodegradation of pollutants has intensified in recent years in an attempt to find sustainable ways to clean contaminated environments. These bioremediation and biotransformation methods take advantage of the tremendous microbial catabolic diversity to degrade, transform or accumulate a variety of compounds, such as hydrocarbons, polychlorinated biphenyls, polaromatic hydrocarbons pharmaceutical substances, radionuclides and metals. Unlike conventional methods, bioremediation does not physically disturb the site. This book describes the basic principles of biodegradation and shows how these principles are related to bioremediation. Authored by leading, international environmental microbiologists, it discusses topics such as aerobic biodegradation, microbial degradation of pollutants, and microbial community dynamics. It provides valuable insights into how biodegration processes work and can be utilised for pollution abatement, and as such appeals to researchers and postgraduate students as well as experts in the field of bioremediation.

Materialart: Online-Ressource

Seiten: IX, 550 p. 69 illus., 48 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811518126

URL: https://doi.org/10.1007/978-981-15-1812-6

DOI: 10.1007/978-981-15-1812-6

DDC: 363.73

Sprache: Englisch

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Atmospheric Reactive Nitrogen in China : Emission, Deposition and Environmental Impacts (2020)

Liu, Xuejun. [editor.] ; Du, Enzai. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Environmental health. ; Sustainability. ; Biotic communities. ; Biodiversity. ; Pollution. ; Environmental Health. ; Sustainability. ; Ecosystems. ; Biodiversity.

Beschreibung / Inhaltsverzeichnis: Chapter 1 Overview of atmospheric reactive nitrogen in China from a global perspective -- Part I Reactive nitrogen emission and deposition in China -- Chapter 2 Anthropogenic emissions of SO2, NOx and NH3 emissions in China -- Chapter 3 Monitoring nitrogen deposition in China -- Chapter 4 Modelling nitrogen deposition in China -- Chapter 5 Reactive nitrogen budgets in China -- Part II Contribution of atmospheric reactive nitrogen to China’s air pollution -- Chapter 6 Contribution of atmospheric reactive nitrogen to haze pollution in China -- Chapter 7 Contribution of reactive nitrogen to ozone pollution in China -- Chapter 8 Contribution of atmospheric nitrogen to acid deposition in China -- Part III Impacts of nitrogen deposition on China’s ecosystems Chapter 9 Impacts of nitrogen deposition on forest ecosystems in China -- Chapter 10 Impact of nitrogen deposition on China’s grassland ecosystems -- Chapter 11 Impact of nitrogen deposition on China’s desert ecosystems -- Chapter 12 Impact of nitrogen deposition on China’s lake ecosystems: Taking Lake Dianchi as an example -- Part IV Reactive N Regulation Chapter 13 Nitrogen regulation in China’s agricultural systems -- Chapter 14 National regulation of SO2 and NOX emissions in China.

Kurzfassung: Atmospheric reactive nitrogen (N) emissions, as an important component of global N cycle, have been significantly altered by anthropogenic activities, and consequently have had a global impact on air pollution and ecosystem services. Due to rapid agricultural, industrial, and urban development, China has been experiencing an increase in reactive N emissions and deposition since the late 1970s. Based on a literature review, this book summarizes recent research on: 1) atmospheric reactive N in China from a global perspective (Chapter 1); 2) atmospheric reactive N emissions, deposition and budget in China (Chapters 2-5); 3) the contribution of atmospheric reactive N to air pollution (e.g., haze, surface O3, and acid deposition) (Chapters 6-8); 4) the impacts of N deposition on sensitive ecosystems (e.g., forests, grasslands, deserts and lakes) (Chapters 9-12); and 5) the regulatory strategies for mitigation of atmospheric reactive N pollution from agricultural and non-agricultural sectors in China (Chapters 13-14). As such it offers graduate students, researchers, educators in agricultural, ecological and environmental sciences, and policy makers a glimpse of the environmental issues related to reactive N in China .

Materialart: Online-Ressource

Seiten: XVII, 331 p. 99 illus., 72 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811385148

URL: https://doi.org/10.1007/978-981-13-8514-8

DOI: 10.1007/978-981-13-8514-8

DDC: 363.73

Sprache: Englisch

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Water Availability and Management in Mexico (2020)

Otazo-Sánchez, Elena María. [editor.] ; Navarro-Frómeta, Amado Enrique. [editor.] ; Singh, Vijay P. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pollution. ; Statistics . ; Geology. ; Geographic information systems. ; Pollution. ; Statistics in Engineering, Physics, Computer Science, Chemistry and Earth Sciences. ; Geology. ; Geographical Information System.

Beschreibung / Inhaltsverzeichnis: 1. Preface -- 2. Acknowledgment -- 3. Part I: Water Availability 1 Overview of the water condition in México -- 4. 2 Hydrological watersheads in Mexico. Division and legal definition -- 5. 3 The Groundwater condition in Mexico -- 6. 4 Runoff simulation under future climate change and uncertainty -- 7. 5 Hydraulic fracking of not conventional reservoirs in Mexico: The issue of water and waste control -- 8. Part II. Water Quality 6 Pollution in wastewater used for irrigation in the Mezquital Valley, México: case study -- 9. 7 Mining industry in Mexico: Recycling of flotation effluents to the process using anaerobic sulfate-reducing consortia in UASB reactors for the elimination dissolved metals -- 10. 8 Water body trophic state determinations. Case study Tecocomulco lagoon, Hidalgo, Mexico -- 11. 9 Water quality management for a sustainable supply. The diagnosis of the State of San Luis Potosi, Mexico -- 12. 10 The wetland of Cajititlán Lake severely deteriorated and in danger of dying out -- 13. 11 Water quality of the Nexapa River: a diagnosis -- 14. 12 Impacts on the groundwater quality that supplies the Puebla City by the effect of aquifer intensive exploitation -- 15. Part III: Water Allocation 13 Water resources allocation with supply and demand uncertainties -- 16. 14 An overview of aquaculture activity in Hidalgo state -- 17. 15 Drinking Water Services Situation by the Region in the State of Nuevo León, Mexico -- 18. 16 Population and tourism dynamics, its effects on the future demand for water. Case study from Los Cabos, Baja California Sur -- 19/ Part IV: Water Governance 17 Water governance in 16 Mexican National Parks -- 20. 18 Conflict in border condition: the dispute over the use of water in the Mexicali valley -- 21. 19 The institutional challenges of the municipalities of Zacatecas in the wastewater treatment -- 22. Part V: Water Management 20 The institutional challenges of the municipalities of Zacatecas in the wastewater treatment -- 23. 21 Improving environmental services of Candelaria River basin by restoring ecological connectivity -- 24. 22 Transdisciplinary approach to assessing socio-hydrological resilience in urban metropolitan environments: a Mexican perspective -- 25. 23 The 80% paradigm: An appointment with the sewage in Cuernavaca.

Kurzfassung: This book presents several complex case studies related to water management and planning in the context of pollution, growing demands, and global climate change in Mexico, but which are also relevant for other countries in Latin America. These concerns are of critical importance for policymakers who are coping with multiple conflicting interests. Water availability in Mexico is polarized, with abundant rainfall and large rivers in the south, and desert-like conditions in the north. The central region, which is the most industrialized, is overpopulated. Mexico City pours millions of cubic meters of “blackwater” into the northern valley daily and receives its clean water from the south. To address these unsustainable conditions, the world's 4th biggest water treatment plant went into operation in 2018. The water infrastructure and governance must satisfy the demands of all sectors, including agricultural, urban, and economic activities. At the same time, water resources are affected by drought, and climate change puts constraints on the supply. As such, regulation and monitoring are important when it comes to adherence to agreed plans and priorities. The book is divided into four sections. 1: Water Availability discusses quantitative aspects, such as supply, methods of calculation, and fracking. 2: Water Quality highlights pollution risks and diagnosis of water resources. 3: Water Allocation examines the sectoral demands and vulnerability due to unsustainable irrigation. 4: Water Management and Governance focuses on laws, urban rules, national parks, planning, and integrated water resources management, among other topics. The chapters include illustrative case studies in Mexico, such as basins, cities, reservoirs, and aquifers, water supply demand assessment, planning, and management.

Materialart: Online-Ressource

Seiten: X, 516 p. 155 illus., 108 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030249625

Serie: Water Science and Technology Library, 88

URL: https://doi.org/10.1007/978-3-030-24962-5

DOI: 10.1007/978-3-030-24962-5

DDC: 363.73

Sprache: Englisch

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Fresh Water Pollution Dynamics and Remediation (2020)

Qadri, Humaira. [editor.] ; Bhat, Rouf Ahmad. [editor.] ; Mehmood, Mohammad Aneesul. [editor.] ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Water. ; Hydrology. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Freshwater ecology. ; Marine ecology. ; Pollution. ; Water. ; Environmental Engineering/Biotechnology. ; Freshwater and Marine Ecology.

Beschreibung / Inhaltsverzeichnis: The Concerns for Global Sustainability of Freshwater Ecosystems -- Freshwater Pollution: Effects on Aquatic Life and Human Health -- Freshwater contamination: sources and hazards to aquatic biota -- Correlation Between Pollution Trends of Freshwater Bodies and Bacterial Disease of Fish Fauna -- Impact of Pollution on Quality of Freshwater Ecosystems -- Heavy metal intrusion and accumulation in aquatic ecosystems -- Impact of climate change on freshwater ecosystem and its sustainable management -- Role of biotools in restoration of freshwater ecosystems Bioremediation -- A Sustainable and Emerging Tool for Restoration of Polluted Aquatic Ecosystems -- Biosorption as Environmentally Friendly Technique for Heavy Metal Removal from Wastewater -- Biotechnological interventions as an aquatic clean up tool -- Analysis of hydrology, sediment retention, biogenic-calcification and -scavenging as self-remediative lacustrine functions -- Remediation of pesticides through microbial and phytoremediation techniques -- Trends in Phyto-management of Aquatic Ecosystems and Evaluation of Factors Affecting Removal of Inorganic Pollutants from Water Bodies -- Urban Pond Ecosystems: Preservation and Management Through Phytoremediation -- Aquatic Pollution Stress and Role of Biofilms as Environment Cleanup Technology -- Wonders of Nanotechnology for Remediation of Polluted Aquatic Environs.

Kurzfassung: Freshwater is a finite resource and is being deteriorated directly and indirectly by anthropogenic pressures. Preserving the quality and availability of freshwater resources is becoming one of the most pressing environmental challenges on the international horizon. To ensure the preservation as well as availability of freshwater resources, there is a need to understand the ecology of the freshwater systems, pollution problems, their impacts, restoration techniques to be opted and the conservation measures. In this backdrop the present book on ‘Freshwater Pollution Dynamics and Remediation’ has been compiled. The book provides an understanding about the present state of art, pollution impacts including the changes in the environmental quality as well as the shift in the aquatic biological communities of the fragile freshwater ecosystems. Besides, the impact of deteriorating quality of the freshwater ecosystems on the animal and human health is also discussed in detail. This book provides a comprehensive account of the techniques based on updated research in biotechnology, bio-remediation, phyto-remediation and nano-bioremediation. The role of biosorpers and biofilms as a remediation tool has also been detailed. The book is a ready reference for researchers, scientists and educators who are involved in the freshwater pollution, remediation and management studies. The book editors with an expertise in diverse research fields in freshwater ecosystems have congregated the most inclusive research accounts on the freshwater pollution and remediation and thus developed a repository of diverse knowledge on the subject.

Materialart: Online-Ressource

Seiten: XV, 339 p. 49 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811382772

URL: https://doi.org/10.1007/978-981-13-8277-2

DOI: 10.1007/978-981-13-8277-2

DDC: 363.73

Sprache: Englisch

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Advanced Nano-Bio Technologies for Water and Soil Treatment (2020)

Filip, Jan. [editor.] ; Cajthaml, Tomáš. [editor.] ; Najmanová, Petra. [editor.] ; [weitere]

Cham :Springer International Publishing :

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Schlagwort(e): Pollution. ; Refuse and refuse disposal. ; Environmental chemistry. ; Pollution. ; Waste Management/Waste Technology. ; Environmental Chemistry.

Beschreibung / Inhaltsverzeichnis: Preface -- Part I Reductive Technologies -- Geochemical Principles of Reductive Remediation Processes -- Nanoscale Zero-Valent Iron Particles for Water Treatment: from Basic Principles to Field-Scale Applications -- Other Chemical Reductive Methods -- Combination of Electrokinetics and nZVI Remediation -- Field Study I: In Situ Chemical Reduction Using Nanoscale Zero-valent Iron Materials to Degrade Chlorinated Hydrocarbons -- Field Study II: Pilot Application of nZVI/DC-combined Methods at Aargau Site -- Part II Oxidative Technologies -- Introduction to Oxidative Technologies for Water Treatment -- Ferrates as Powerful Oxidants in Water Treatment Technologies -- Radical Reactions and Their Application for Water Treatment -- Photo-oxidation Technologies for Advanced Water Treatment -- The Use of Nanomaterials in Electro-Fenton and Photoelectro-Fenton Processes -- Field Study III: Evidence Gained from Site Studies for the Performance of Ferrate(VI) in Water and Wastewater Treatment -- Field Study IV: Arsenic Removal from Groundwater by Ferrate with the Concurrent Disinfecting Effect—Semi-pilot on-site Application -- Field Study V: Combined Oxidation Technology using Ferrates (FeIV–VI) and Hydrogen Peroxide for Rapid and Effective Remediation of Contaminated Water—Comprehensive Practically Focused Study -- Part III Biotechnologies for Water Treatment -- Biotechnologies for Water Treatment -- Enzyme-Based Nanomaterials in Bioremediation -- Bioelectrochemical Processes for the Treatment of Oil-Contaminated Water and Sediments -- Field Study VI: The Effect of Loading Strategies on Removal Efficiencies of a Hybrid Constructed Wetland Treating mixed Domestic and Agro-Industrial Wastewaters -- Field Study VII: Field Study of Three Different Injectable Oxygen Sources to Enhance Mono-Aromatic Solvents in situ Biodegradation -- Field Study VIII: Nano-bioremediation: nZVI for Inorganic and Organic Contamination -- Part IV Biotechnologies for Soil Treatment -- Biotechnologies for Soil Treatment -- Mycoremediation of Contaminated Soils -- Composting Practices for the Remediation of Matrices Contaminated by Recalcitrant Organic Pollutants -- Modern Bioremediation Approaches: Use of Biosurfactants, Emulsifiers, Enzymes, Biopesticides, GMOs -- Field Study IX: Pilot-Scale Composting of PAH-Contaminated Materials—Two Different Approaches -- Field Study X: Oil Waste Processing Using Combination of Physical Pretreatment and Bioremediation -- Part V Ecotoxicology of Both Environmental Pollutants and Nanomaterials Used for Remediation -- Ecotoxicology of Environmental Pollutants -- Ecotoxicity of Nanomaterials Used for Remediation -- VI Future Prospects -- Future Prospects for Treating Contaminants of Emerging Concern in Water and Soils/Sediments -- Part VII Technical Chapters -- Tool I: Characterization of nZVI Mobility in 1D and Cascade Columns by Ferromagnetic Susceptibility Sensor -- Tool II: Membrane Interface Probe -- Tool III: Fracturing for Enhanced Delivery of In situ Remediation Substances in Contaminated Sediments -- Tool IV: Monitoring of nZVI Migration and Fate in the Groundwater Conditions -- Tool V: Microbiological Methods for Monitoring nZVI Performance in Groundwater Conditions.

Kurzfassung: This edited work presents a comprehensive treatise on the latest progress in the field of selected innovative nanotechnologies, biotechnologies, and their possible combinations for efficient elimination of a broad range of pollutants from various types of water and soil. It covers the underlying principles of all the key technologies (reductive and oxidative technologies for water treatment and biotechnologies for water and soil treatment). Moreover, it includes toxicological evaluation of emerging pollutants and novel engineered nanoparticles, as well as providing results of field-scale verification and application of the most promising technologies. Central aspects covered in this book include: geochemistry of iron, properties of iron nanoparticles (nZVI) and related materials for water treatment, in situ methods for groundwater treatment, evaluation of various combined nano/bio technologies, mechanisms and efficiencies of degradation/dechlorination of chlorinated hydrocarbons (as well as other organic pollutants like POPs, PAHs, etc.), elimination of arsenic and Cr(VI) from water, advanced oxidation processes with a strong focus on high-valent states of iron (ferrates), radical reactions, photooxidation, Fenton reactions, disinfection, and biodegradation including mycoremediation and composting of a wide range of pollutants from water and soil. In addition, technical details of selected strategies adopted for a pilot/full-scale application of key nano-/biotechnologies, i.e. nZVI injection into groundwater, field-scale contaminant monitoring, nanoparticle migration, and microbiological methods for monitoring nZVI performance in groundwater conditions, are presented. Therefore, this multidisciplinary book will be suitable for a broad readership including environmental scientists, practitioners, policymakers, toxicologists, and, of course, students of diverse fields such as materials science, chemistry, biology, geology, hydrogeology, engineering, etc.

Materialart: Online-Ressource

Seiten: XXV, 657 p. 210 illus., 133 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030298401

Serie: Applied Environmental Science and Engineering for a Sustainable Future,

URL: https://doi.org/10.1007/978-3-030-29840-1

DOI: 10.1007/978-3-030-29840-1

DDC: 363.73

Sprache: Englisch

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Prospects of Fresh Market Wastes Management in Developing Countries (2020)

Al-Gheethi, Adel Ali Saeed. [editor.] ; Radin Mohamed, Radin Maya Saphira. [editor.] ; Noman, Efaq Ali. [editor.] ; [weitere]

Cham :Springer International Publishing :

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Schlagwort(e): Pollution. ; Water. ; Hydrology. ; Refuse and refuse disposal. ; Green chemistry. ; Economic development. ; Pollution. ; Water. ; Waste Management/Waste Technology. ; Green Chemistry. ; Development Studies.

Beschreibung / Inhaltsverzeichnis: 1. Characterization of fresh market wastewater and solid wastes -- 2. Fresh market wastes Management Practices and Their Impact on Human Health -- 3. Treatment Technologies of fresh market wastewater -- 4. Generation of Polycyclic Aromatic Hydrocarbons from Microalgae Biomass of fresh Market Wastewater Phycoremediation -- 5. Application of Natural Coagulants for fresh market wastewater Treatment -- 6. Anaerobic Digestion of fresh solid wastes -- 7. Electricity production from fresh solid wastes using microbial fuel cells -- 8. Remediation of xenobiotics in fresh market wastewater using nanotechnoogy -- 9. Biofilter Aquaponic system for nutrients removal from fresh market wastewater -- 10. Reduction of poultry slaughterhouse wastewater pollutants using sequencing batch reactors (SBR) enhanced by composite fibre for safe disposal.

Kurzfassung: This book focuses on the prospects of fresh market waste management in developing countries. It characterizes fresh market wastewater and solid wastes, and highlights the human health impact of corresponding waste management practices. With regard to treatment technologies, the book discusses the anaerobic digestion of fresh solid wastes; the application of natural coagulants for wastewater treatment; the remediation of xenobiotics in wastewater using nanotechnology; and biofilter aquaponic systems for nutrient removal. All of these technologies are recent innovations, offer several concrete advantages, and can be applied in developing countries as non-central treatment systems. In addition, the book covers electricity production from fresh solid wastes using microbial fuel cells, demonstrating the potential held by recycling fresh market wastewater and solid wastes.

Materialart: Online-Ressource

Seiten: XI, 178 p. 33 illus., 18 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030426415

Serie: Water Science and Technology Library, 92

URL: https://doi.org/10.1007/978-3-030-42641-5

DOI: 10.1007/978-3-030-42641-5

DDC: 363.73

Sprache: Englisch

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Resilience of Large Water Management Infrastructure : Solutions from Modern Atmospheric Science (2020)

Hossain, Faisal. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pollution. ; Water. ; Hydrology. ; Atmospheric science. ; Civil engineering. ; Climatology. ; Sustainability. ; Pollution. ; Water. ; Atmospheric Science. ; Civil Engineering. ; Climate Sciences. ; Sustainability.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Resilience Of Large Water Management Infrastructure -- Chapter 2. Survey Of Water Managers For 21st Century Challenges -- Chapter 3. Current Approaches For Resilience Assessment -- Chapter 4. Application Of Numerical Atmospheric Models -- Chapter 5. Infrastructure-Relevant Storms Of The Last Century -- Chapter 6. Sensitivity Of Probable Maximum Precipitation (PMP) -- Chapter 7. A Recommended Paradigm Shift In The Approach To Risks To Large Water Infrastructure In The Coming Decades -- Chapter 8. Safety Design of Water Infrastructures In A Modern Era.

Kurzfassung: Infrastructure that manages our water resources (such as, dams and reservoirs, irrigation systems, channels, navigation waterways, water and wastewater treatment facilities, storm drainage systems, urban water distribution and sanitation systems), are critical to all sectors of an economy. Realizing the importance of water infrastructures, efforts have already begun on understanding the sustainability and resilience of such systems under changing conditions expected in the future. The goal of this collected work is to raise awareness among civil engineers of the various implications of landscape change and non-climate drivers on the resilience of water management infrastructure. It identifies the knowledge gaps and then provides effective and complementary approaches to assimilate knowledge discovery on local (mesoscale)-to-regional landscape drivers to improve practices on design, operations and preservation of large water infrastructure systems.

Materialart: Online-Ressource

Seiten: XV, 124 p. 42 illus., 37 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030264321

URL: https://doi.org/10.1007/978-3-030-26432-1

DOI: 10.1007/978-3-030-26432-1

DDC: 363.73

Sprache: Englisch

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Measurement, Analysis and Remediation of Environmental Pollutants (2020)

Gupta, Tarun. [editor.] ; Singh, Swatantra Pratap. [editor.] ; Rajput, Prashant. [editor.] ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Environmental monitoring. ; Environmental chemistry. ; Pollution. ; Environmental Engineering/Biotechnology. ; Environmental Monitoring. ; Environmental Chemistry.

Beschreibung / Inhaltsverzeichnis: Quantification of Airborne Particulate And Associated Toxic Heavy Metals in Urban Indoor Environment and Allied Health Effects -- In-Situ Measurements of Aerosols from the High-Altitude Location in the Central Himalayas -- Significant Annual Variation in Atmospheric Pollutants during Fireworks Festival, ‘Diwali’ in Capital City of India -- Organic Air Pollutants: Measurement, Properties & Control -- Emissions of Particle-Bound Metals from On-Road Vehicle Emission: An Assessment of Potential Health Risk -- Chemical Composition Analysis of Airborne Coarse Particles and Their Source Apportionment at Kanpur -- Analysis of the Aerosols Environment in an Urban Context and Their Impact On Regional Meteorology -- Calipso Retrieval of Smoke Aerosols Over Upper Indo-Gangetic Plain -- Spatio-Temporal Study of Optical and Microphysical Properties of Atmospheric Brown Clouds Over the Indo-Gangetic Plains -- Spatial Variation of Airborne Allergenic Fungal Spores in the Ambient Pm2.5 — A Study in Rajkot City, Western Part of India -- Bioaerosol Health Effects from Moleculer to Global Scales -- Measurement, Analysis and Remediation of Biological Pollutants in Water -- Fundamentals of Measurement, Analysis, and Treatment of Selenium in Water -- Bioleaching of Selected Metals from E-Waste using Pure and Mixed Cultures of Aspergillus Species -- Recent Advances In Micro-Extraction Based Analytical Approaches For Pesticides Analysis In Environmental Samples -- Degradation and Removal of Anticonvulsant Drugs Through Microorganisms: A Review -- Remediation Approaches for Hexavalent Chromium -- Mercury and Its Remediation -- Oxidative Potential of Particulate Matter: A Prospective Measure to Assess Pm Toxicity -- Monitoring and Processing of Data for Effective Wasteload Allocation Modeling: Indian Perspective -- Methane Emission from Municipal Solid Waste Landfills – Estimation and Control -- Low-Cost Adsorptive Removal Techniques for Pharmaceuticals and Personal Care Products -- Measurement, Analysis, and Remediation of Bisphenol-A from Environmental Matrices -- Removal of Chromium Ions from Aqueous Solution using Eco-Friendly Based Adsorbents.

Kurzfassung: This book discusses contamination of water, air, and soil media. The book covers health effects of such contamination and discusses remedial measures to improve the situation. Contributions by experts provide a comprehensive discussion on the latest developments in the detection and analysis of contaminants, enabling researchers to understand the evolution of these pollutants in real time and develop more accurate source apportionment of these pollutants. The contents of this book will be of interest to researchers, professionals, and policy makers alike.

Materialart: Online-Ressource

Seiten: XVIII, 474 p. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811505409

Serie: Energy, Environment, and Sustainability,

URL: https://doi.org/10.1007/978-981-15-0540-9

DOI: 10.1007/978-981-15-0540-9

DDC: 363.73

Sprache: Englisch

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Water Resources Management in Romania (2020)

Negm, Abdelazim M. [editor.] ; Romanescu, Gheorghe. [editor.] ; Zeleňáková, Martina. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pollution. ; Water. ; Hydrology. ; Physical geography. ; Pollution. ; Water. ; Physical Geography.

Beschreibung / Inhaltsverzeichnis: Introduction -- Management of Surface Water Resources In Romania -- The Vulnerability of Water Resources From Eastern Romania to Anthropic Impact and Climate Changes -- Romanian Danube River Floodplain Functionality Assessment -- Romanian Upper Tisa Watershed, Between Water Resources and Hydrological Hazards -- Causes and Effects of Water Pollution in Romania -- Assessment of Some Diurnal Streamwater Profiles in Western and Northern Romania in Relation to Meteorological Data -- Water Resources Management in Razim-Sinoie Lakes Ecosystems -- Particularities of Drain Liquid in the Small Wetland of Braila Natural Park, Romania -- Water Supply Challenges and Achievements in Constanta County -- Drinking Water Supply Systems - Evolution towards Efficiency -- Water Resources Management in Siret Catchment -- Particular Hydrological Manifestations on the Lower Danube in the Current Climate -- Hydrological Impacts of Climate Changes in Romania and Adaptation Strategies -- Implementation of EU Water Framework Directive (2000/60/CE) in Romania - European Qualitative Requirements -- Drought and Insolvency: Case study of the Producer-Buyer Conflict (Romania, the period between the year 2011-2012) -- Conclusions and Recomendations. .

Kurzfassung: This book discusses water resources management in Romania from a hydrological perspective, presenting the latest research developments and state-of-the-art knowledge that can be applied to efficiently solve a variety of problems in integrated water resources management. It focuses on a wide range of water resources issues – from hydrology and water quantity, quality and supply to flood protection, hydrological hazards and ecosystems, and includes case studies from various watersheds in Romania. As such, the book appeals to researchers, practitioners and graduates as well as to anybody interested in water resources management.

Materialart: Online-Ressource

Seiten: XII, 591 p. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030223205

Serie: Springer Water,

URL: https://doi.org/10.1007/978-3-030-22320-5

DOI: 10.1007/978-3-030-22320-5

DDC: 363.73

Sprache: Englisch

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Arsenic in Drinking Water and Food (2020)

Srivastava, Sudhakar. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pollution. ; Refuse and refuse disposal. ; Sustainability. ; Food science. ; Nutrition . ; Pollution. ; Waste Management/Waste Technology. ; Sustainability. ; Food Science. ; Nutrition.

Kurzfassung: Arsenic contamination poses a major environmental problem, especially in Southeast Asian countries like Bangladesh and India. Threatening the health of millions of people due to arsenic’s toxicity and carcinogenicity, the major routes of arsenic exposure for humans are either through drinking water or crops. Rice is the crop most affected by arsenic owing to its cultivation in major arsenic contaminated areas, biogeochemical factors in the soil during rice growth, and specific features of rice that enable it take up more arsenic than other crop plants. This book addresses the problem of arsenic by pursuing a holistic approach. It presents the status quo in different parts of the world (North and South America, Europe, Asia, etc.) and provides essential information on food-related arsenic exposure risks for humans, and possible preventive and curative measures for tackling arsenic poisoning. It covers the arsenic contamination status of rice, rice-based products, other vegetables, fishes, mushrooms, and other foods, with a special focus on rice-arsenic interactions. The mechanisms of arsenic uptake, translocation and distribution in plants and grains are also explained. In closing, the book reviews a variety of prospective agronomic and biotechnological solutions to the problem of arsenic accumulation in rice grains. The book is intended for a broad audience including researchers, scientists, and readers with diverse backgrounds including agriculture, environmental science, food science, environmental management, and human health. It can also be used as an important reference guide for undergraduate and graduate students, university faculties, and environmentalists.

Materialart: Online-Ressource

Seiten: XIII, 460 p. 44 illus., 24 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811385872

URL: https://doi.org/10.1007/978-981-13-8587-2

DOI: 10.1007/978-981-13-8587-2

DDC: 363.73

Sprache: Englisch

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