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  • Books  (90)
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  • Cham :Springer International Publishing :  (90)
  • Bremerhaven : Alfred-Wegener-Inst. für Polar- und Meeresforschung
  • University of Virginia Library
  • Wabern : Federal Office of Topography, Swiss Geological Survey
  • 307.76  (45)
  • 571.978  (45)
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  • Books  (90)
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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.
    Abstract: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).
    Type of Medium: Online Resource
    Pages: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031229039
    Series Statement: Current Cancer Research,
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Treatment. ; Neurosciences. ; Immunotherapy. ; Cancer Biology. ; Cancer Therapy. ; Neuroscience. ; Cancer Microenvironment. ; Immunotherapy.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.
    Abstract: This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.
    Type of Medium: Online Resource
    Pages: XII, 202 p. 21 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324291
    DDC: 571.978
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.
    Description / Table of Contents: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.
    Abstract: This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.
    Type of Medium: Online Resource
    Pages: XXI, 542 p. 229 illus., 221 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031162862
    DDC: 571.978
    Language: English
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  • 4
    Keywords: Urban policy. ; Sustainability. ; Architecture. ; Urban Policy. ; Sustainability. ; Cities, Countries, Regions.
    Description / Table of Contents: Part 1: Tourism dynamics in urban city centres -- Towards resilient urbanism in tourist cities: post-pandemic challenges -- The pain of being a resident in Granada. Analysis of the accommodation offer and residents´ perception -- Recent socio-spatial transformations in the San Pedro neighbourhood (Santiago de Compostela) -- The touristification of historic centres through commercial gentrification in times of Covid-19 -- Citizen resistance in touristified neighborhoods. A post-pandemic análisis -- Neoliberalism, collaborative economy, and short-term rentals regulation in Andalusia, Spain -- Changes in the role of heritage in historic centres: the mutation of historic buildings into tourist accommodation -- Part 2: Urban-tourist spaces on the coast: New urbanised spaces and resistance -- Urban-tourism spaces on the coast: transformations, challenges and globalisation in uncertain scenarios -- Landscape preservation on the Mediterranean coast; do social movements play a decisive role? The case of the Costa Brava (Spain) -- The construction of sustainable territorial models in the aftermath of the Covid-19 pandemic: Lessons from medium-sized Mediterranean cities -- Housing change during the Covid-19 pandemic in the metropolitan areas of the Canary Island capitals (Spain) -- Two megaprojects – One city. Learning between large-scale urban development projects on Tenerife, Spain -- Touristification process in seaside destination inland: The case of Mallorca Island, Spain -- Part 3: Urban transformations: New dynamics, conflicts and challenges in a context of uncertainty -- Towards urban degrowth? Urban planning as a common thread of contradictory dynamics in cities -- Shrinking cities in Spain: Shrinking medium-sized cities in the 21st century. Depopulation and employment -- The peripheries of Spanish developmentalism. an enduring model of urban fragmentation -- Housing, a problem perpetuated over time in Spain. New initiatives to promote access to affordable housing in Madrid -- Residential expectations in a neoliberal perspective: A sociological view of social classes and the right to housing -- (Re)thinking gentrification processes. The place of religion -- Metropolitan spatial reconfiguration and the mobility transition: Sustainability challenges in the fragmented city -- Sustainability and urban development strategies: Ciudad Real -- Part 4: Postscript -- Intra-urban borders in border cities: The nationally interchangeable dynamics of urban centrality.
    Abstract: This book offers a unique perspective on urban processes affecting tourist spaces and city centres. Economic, social and environmental uncertainty has been commonplace since March 2019, when mobility slowed down across the globe. The COVID-19 pandemic accelerated trends that have been investigated in urban space for years. The incorporation of technologies, the expansion of tourism and the introduction of policies that in part want to advance sustainability are generating processes of reorganisation of territories that are driving changes. These changes will affect models of city, urbanism and society. This publication is directed to a wide spectrum of people interested in urban processes, tourism and social change in the context of the Post-Pandemic Covid-19. In particular, the book is aimed at researchers, undergraduate and postgraduate students, consultants, public administrations and the public interested in the recent challenges that are affecting developed and developing societies.
    Type of Medium: Online Resource
    Pages: XII, 371 p. 103 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031360176
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Urban policy. ; Human geography. ; Architecture. ; Social justice. ; Urban Policy. ; Human Geography. ; Cities, Countries, Regions. ; Social Justice.
    Description / Table of Contents: Introduction -- An enquiry into planning for justice -- From aspirational to operational: Towards an integrated approach to spatial justice -- Urban regeneration and social housing redevelopment in Aotearoa New Zealand: Issues and challenges -- Historical-Geographical analysis of spatial differentiations -- Changing social housing policy in the context of neoliberalism -- People, place and policy -- Spatial justice and planning: Bridging the gap.
    Abstract: Despite the significance of urban justice in planning research and practice, how just societies and cities can be organised and achieved remains contested. Spatial justice provides an integrative and unifying theory concerning place, policies, people and their interplay, but ambiguities about its practical bases have undermined its application in planning. Through creating and substantiating a new conceptual framework comprising a morphological study, policy analysis and embodiment research, this book crystallises the spatiality of (in)justice and (in)justice of spatiality in the context of social housing redevelopment. Like many countries around the world, social housing in Aotearoa New Zealand is an area of contention, especially at the building and redevelopment stages. Protecting community character and human rights has been used by social housing tenants to resist changes, but the primary focus on material outcomes neglects broadening access to planning processes. Compact, mixed tenure and sustainable (re)developments are regarded as the just built environment, as they enable equal accessibility to all. But there are contradictions between the planned spatiality of justice and individuals’ socialised sensory space. Reconciliation of morphological differentiations in built forms and social cohesion remains a challenging task. This book focuses on the re-examination, integration and transferability of spatial justice. It makes a new contribution to urban justice theory by strengthening spatial justice and planning. Social housing areas are expected to adapt to changing social and economic demands while retaining much-valued established community character. This book also provides practical strategies for tackling complex planning problems in social housing redevelopment.
    Type of Medium: Online Resource
    Pages: XIX, 172 p. 40 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031380709
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 6
    Keywords: Urban policy. ; Sustainability. ; Urban Policy. ; Sustainability.
    Description / Table of Contents: Part 1: The research -- Post-pandemic challenges. The role of local governance for territorial resilience -- Part 2: Topics -- Notes of spatial implications of Covid-19. Evidence from Piedmont Region, Italy -- The role of the minor hydrographic system in increasing the ecological network -- Ecosystem services and territorial resilience: The role of green and blue infrastructure -- Indicators and scenarios for sustainable development at the local level -- Towards neighborhoods as minimum units of resilience?- Part 3: Case studies -- NO2 concentrations and Covid-19 in local systems of North-West Italy -- The COVID-19 effects and the development process of Lanzo Valleys in a metro-mountain perspective -- Analysis of hydrogeological risks related to climate change: Testing the ClimeApp assessment tool on the Torino Nord Homogenous Zone -- From knowledge to land-use planning: Local resilient experience in the territory of the municipality of Mappano -- Space for rights. The school between urban standards and social innovation -- Part 4: Digital tools -- The 3D metric survey for the digital cartographic production to support the knowledge of the new Municipality of Mappano -- Sources and data for the analysis of the metropolitan territory with GIS tools -- Part 5: Lesson learned and perspectives -- Final remarks on the implementation of the post-pandemic city and the role of technology.
    Abstract: This open access book builds a framework that holds together numerous open issues in territorial planning: from the understanding of territorial, landscape, environmental and climatic dynamics to the analysis of local vulnerabilities, to the use of modern survey techniques to support planning. What is the role of urban and regional planning in achieving the sustainable development goals of our communities considering the major issues posed by the COVID-19 pandemic in urban planning? And how do these medium- and long-term objectives interact with the needs that the emergency has given rise to? Post Un-Lock—from territorial vulnerabilities to local resilience—aims to provide the reader with a useful key to understand how the COVID-19 pandemic can be seen as a catalyst for a restart based on the concepts of sustainability and resilience. In fact, the COVID-19 experience evidences the need to propose a planning system able to integrate multiple scales according to an interdisciplinary approach focused on in-depth knowledge of the territorial risks and vulnerabilities. Besides, with the contribution of the new technologies, it is able to rethink spaces on a neighbourhood scale, conceived as a "local resilience unit" that ensures the population high standards of safety, liveability, and accessibility to proximity services. In this view, planning is increasingly concerned about social aspects and the well-being of communities, supported by indicators and evaluation tools. With the proposal of the concept of local resilience unit, Post Un-Lock takes a step forward towards the definition of a new paradigm of local planning and a topic for urban regeneration.
    Type of Medium: Online Resource
    Pages: VIII, 189 p. 53 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031338946
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Urban policy. ; Human geography. ; Urban Policy. ; Human Geography.
    Description / Table of Contents: Inquiring into self-organization and the self-organized city -- Informality and responding to the challenges of informal settlements -- Key concepts in understanding self-organization and the self-organized city -- Urbanization and the development of the Kampung in Indonesia -- Kampung Marlina, Jakarta -- Kampung Pakualaman, Yogyakarta -- Kampungs Lebak Siliwangi and Tamansari, Bandung -- Beyond the informal – Better understanding self-organization and the self-organized city.
    Abstract: This book provides a much-needed analysis of the pivotal role of the urban kampung in Indonesia’s urbanization process and importantly, provides a deeper understanding of how these communities create their complex socio-physical environments through self-organization. The book challenges the current formal approaches and practices to modern planning in Indonesia where many kampungs are classed as illegal and excluded from city plans. Beyond informality unpacks via 3 case studies the self-generated planning and development arrangements and mechanisms which occur parallel to processes of formal exclusion, adaptation, negotiation and modification. Kampungs are posited as inseparable urban entities contributing to the complex assemblage of the city and the dynamics of contemporary urban planning and design. In the context of planning and design practice, this book provides a better understanding on how one needs to consider human-scale urbanism to achieve more effective and efficient planning plans and policies in the self-organized city. Even though self-organization by residents comes with its challenges as outlined in the book, formal planning in both Indonesia and other developing countries has much to learn from understanding self-organized settlements (kampung) and informal settlements ‘as they are’.
    Type of Medium: Online Resource
    Pages: XXIX, 161 p. 109 illus., 106 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031222399
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 8
    Keywords: Urban policy. ; Human geography. ; Cultural geography. ; Cultural property. ; Urban Policy. ; Social and Cultural Geography. ; Cultural Heritage.
    Description / Table of Contents: Chapter 1: The Lived Experiences of Zimbabwean Borderlands -- Chapter 2: Peasant Accumulation and Livelihoods Strategies in Zimbabwe’s Mozambican Borderlands -- Chapter 3: Slippery Bananas? Environmental Conflicts, Banana Production and Entangled Livelihoods along the Zimbabwe-Mozambican border with specific reference to Honde Valley, 1992 – 2020 -- Chapter 4: Land Rights, Displacements and Rural Livelihoods in Zimbabwe’s South-Eastern Borderlands -- Chapter 5: Borders, Boundaries, and Livelihoods in Western and North-Western Zimbabwe, 1890 – 2021 -- Chapter 6: Local Community Perceptions on Wildlife Conservation and Park-People Relationships in the Sengwe Area, Chiredzi District, Southeast Zimbabwe -- Chapter 7: Understanding the Complexities of Human Conflict Over Wildlife in the Border Town of Kariba, Zimbabwe -- Chapter 8: The Nexus between the Zimbabwe’s Borderlands, Marginalised Peoples, Community Archiving and Archival Activism 4 -- Chapter 9: Entangled Borderlands: Effects of the 1978-1992 Mozambican Civil War on Border Communities in Zimbabwe -- Chapter 10: “Across the border, you are treated well, they care:” Patients, Travels and Therapeutic Mobilities in Honde Valley and Kariba Borderlands -- Chapter 11: The Covid-19 Pandemic and Tourism in Kariba Border Town -- Chapter 12: The Health Seeking Behaviour of Borderline Communities: The Status of the San People of Tsholotsho, Zimbabwe -- Chapter 13: Unfolding Realities of Urbanism at the Margins: Beitbridge (Zimbabwe) and Musina (South Africa) Border Towns as a Single Urban Frontier.
    Abstract: This book examines the national borders and borderlands of Zimbabwe through the presentation of empirically rich case studies. It delves into the lived experiences, both past and present, of populations residing along the borders between Zimbabwe and its neighbours, i.e., Zambia, Botswana, South Africa and Mozambique. It locates these lived experiences within the political economy of Zimbabwe, and highlights a wide range of themes pertinent to borders, including health, COVID-19, marginalisation, resource access, conservation, human-wildlife conflicts, civil wars, politico-economic crises, border jumping and cross border trade. The borderland communities discussed also include ethnic minorities such as the Tonga, San, Ndau, Shangane, and Kalanga. Overall, the book demonstrates the centrality of borders to the Zimbabwean nation-state and the importance of reading history, politics and society from the borderlands. The book fits into the wider prevailing literature of border and borderlands in Africa and beyond and thus has appeal far beyond Zimbabwe. Its diverse themes also relate to topics covered in multiple disciplines, including history, anthropology, and sociology. Academics, development specialists and policy makers will benefit in different ways from the depth and breadth of the analysis in the book.
    Type of Medium: Online Resource
    Pages: XI, 214 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031321955
    Series Statement: Springer Geography,
    DDC: 307.76
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Stem cells. ; Cytology. ; Developmental biology. ; Cancer Stem Cells. ; Cell Biology. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Assays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis.
    Abstract: This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understanding of the role of autophagy in stem cells, including germline stem cells. Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 41 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031173622
    Series Statement: Stem Cell Biology and Regenerative Medicine, 73
    DDC: 571.978
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Animal models. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Models. ; Cancer Therapy. ; Cancer Genetics and Genomics. ; Cancer Microenvironment.
    Description / Table of Contents: Chapter 1: Cancer as a Disease of Cell Proliferation -- Chapter 2: Genetic and Chromosomal Instability -- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function -- Chapter 4: The DNA Damage Checkpoint -- Chapter 5: Dynamics of the Spindle Assembly Checkpoint -- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance -- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy -- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy -- Chapter 9: The Cancer Stem Cell and Tumour Progression -- Chapter 10: Evading the antitumour immune response -- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention -- Chapter 12: In science, all conclusions are provisional.
    Abstract: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.
    Type of Medium: Online Resource
    Pages: XIV, 269 p. 96 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031325731
    DDC: 571.978
    Language: English
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  • 11
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Urban policy. ; Agriculture. ; Social justice. ; Urban Policy. ; Agriculture. ; Social Justice.
    Description / Table of Contents: Introduction -- Part I: A Political Ecology Lens -- Chapter 1. Vulnerable, Yet Resilient -- Part Ii: Social Networks And Access To Resources -- Chapter 2. Urban Food System Concepts -- Part Iii: Solutions Without Resolution -- Chapter 3. Land, Knowledge, Strategies -- Postscript: Final Reflection -- References.
    Abstract: This book explores how power relationships, measured through qualitative social network analysis, impact planning participation and livelihood strategies of a marginalized group of farmers cultivating the Yamuna River floodplain in Delhi, India. Through an in-depth study of 165 farming households facing land development, this book offers insights from the ground-up into how social dynamics enable and constrain agency. A novel mixed-methods approach was used to measure social networks and access to resources based on the different types of people farmers might interact with as part of their livelihoods: hired laborers, vendors, other farmers, etc. Digging deeper into social network patterns, typologies of power are illustrated as they manifest household agency through diverse pathways. More broadly, a political ecology lens is used to link together the multiple and fragmented Yamuna farmers’ stories with broader social, ecological, infrastructural, and economic contexts to suggest future directions for inquiry and policy related to localized urban food systems and sustainable development. This monograph will be of interest to academic faculty and graduate students in critical geography, cultural anthropology, food studies, landscape architecture/urban planning, and sociology. .
    Type of Medium: Online Resource
    Pages: XXIII, 276 p. 36 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031263804
    Series Statement: Cities and Nature,
    DDC: 307.76
    Language: English
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  • 12
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Human geography. ; Urban policy. ; Geography. ; Urban Sociology. ; Human Geography. ; Urban Policy. ; Regional Geography.
    Description / Table of Contents: Part 1: Introduction -- Introduction. Urbicidio: An unprecedented methodological entry in urban studies?- Part 2: Urbicidio. The death of the city -- Urbicide. The liturgical murder of the city -- Death by theory and the power of ideas: From theories of cities to “Smart” Cities -- Urbicide: Towards a conceptualization -- Urban order and disorder. Genealogy of urbicide -- Imaginaries and archetypes on the death of the city -- Covid 19 and the city: Reframing our Understanding of Urbicide by Learning from the Pandemic -- Part 3: Aniquilation: The end of the public space -- The ideology of public space and the new urban hygienism: Tactical urbanism in times of pandemic -- The transformation of urban and digital spaces from a democratic perspective -- Streets, avenues and highways -- The post-automobile city. From deterritorialization to the proximity city: The case of Madrid -- Mobility as an expression of the Urbicide: The risks of transport modernization in Latin American metropolises -- Part 4: Deterioration of the building environment -- The urbanization of risk -- Urbicide or suicide? Shaping environmental risk in an urban growth context: The example of Quito city (Ecuador) -- Between greens and grays: Urbanization and territorial destruction in the Sabana de Bogotá -- Overregulation, corruption and Urbicide -- Obsolescence of the building environment -- Part 5: Dissolution of social interaction -- The (un)made city: Spatial fragmentation, social inequalities and (de)compositions of urban life -- The city and the abandonment of public space. Between neoliberal urbanism and citizen urbanism -- A “New” urban colonialism? North-South migration and racially structured gentrification in Latin America -- Urban frontiers in the fracturing city: Heritage, tourism and immigration -- The production of emptied places in the borderlands of the metropolitan area of Buenos Aires -- Part 6: Degradation and abandonment -- Reconstructing cultural paradigms. Experiences in East Europe: The historical memory of the historical centers in Lithuania -- Lose the memory, lose the history, lose the city -- Revolt and destruction. The public and monument landscape in Latin American cities -- Trends of urban and territorial reconfiguration in metropolitan Buenos Aires -- Anatomy of an Urbicide. Social housing in Santiago 1980-2006 -- Urbicide. A look through the mirror -- Part 7: Destruction of common life: Violence -- The besieged city: Geographies of crime -- Urbicide, violence and destruction against cities by criminal organizations -- Discursive understandings of the city and the persistence of gender inequality -- Border cities between life and death: Ciudad Juárez and El Paso -- Part 8: Contraction of public management: Privatization -- The metamorphosis of infrastructure in Latin American urbanization: From insufficiency to presence as fictitious capital -- Public policies (or their absence) as part of urban destruction -- Metropolitanicide? Urbs, polis and civitas revisited -- International tourism, urban rehabilitation and the destruction of informal income-earning opportunities -- De-urbanization: From the shock to the revolution of a new urban logic -- Part 9: Urbicide: Cities cases -- Grassroots spaces make London exciting: The relationship between the civitas and the urbs -- Rio de Janeiro: The trajectory of the wonderful city, violence, and urban disenchantment -- The implosion of memory. City and drug trafficking in Medellín and the Aburrá Valley -- Caracas. Urbicide and precariousness of urban life at the beginning of the Venezuelan 21st century. The worst of capitalism and savage populism -- Santiago, the non-city? Destruction, creation, and precariousness of verticalized space -- Neoliberal urbicide in Barcelona. The case of Ciutat Vella -- Part 10: Epilogue -- Epilogue. Remake us from Ruins, collective memories and dreams -- Epilogue. The power of urban destruction.
    Abstract: This book uses the reflection of academics specialized in the urban area of Latin America, Europe and the United States, to initiate a comparative debate of the different dynamics in which Urbicidio expresses itself.The field or focal point of analysis that this publication approaches is the city, but under a new critical perspective of inverse methodology to that has been traditional used. It is about understanding the structural causes of self-destruction to finally thinking better and then going from pessimism to optimism. It is a deep look at the city from an unconventional entrance, because it is about knowing and analyzing what the city loses by the action deployed by own urbanites, both in the field of its production and in the field of its consumption. This suppose that the city does not have an ascending linear sequential evolution in its development but neither in each of its parts in the improvement process, showing the face that commonly not seen but others live. The category used for this purpose is that of Urbicidio or the death of the city, which contributes theoretically and methodologically to the knowledge of the city, as well as to the design of urban policies that neutralize it. In addition, it is worth mentioning that the book has an inclusive view of the authors. For this reason, gender parity, territorial representation and the presence of age groups have been sought.
    Type of Medium: Online Resource
    Pages: XV, 945 p. 107 illus., 80 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031253041
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 13
    Keywords: Urban policy. ; Demography. ; Population. ; Human ecology Study and teaching. ; Urban Policy. ; Population and Demography. ; Environmental Studies.
    Abstract: Urban expansion beyond the city’s administrative boundaries has altered villages to a great extent. These peri-urban villages are experiencing unforeseen changes in demographic, economic, land-use, and environmental characteristics. The concept of peri-urbanization is grabbing the attention of urban planners and policymakers globally. To understand the dynamics of the peri-urban region it is crucial to examine multiple rural and urban characteristics. This book studies major changes in population, land and development with the integration of remotely sensed data and census data for 615 peri-urban villages surrounding Ahmedabad city of India. The chapters of the book are designed to cover key aspects of peri-urban change with geospatial methods. This book offers a comprehensive understanding and importance of analyzing peri-urban dynamics at the smallest spatial unit. It provides a detailed conceptual and methodological framework for the students and researchers to study peri-urbanization as well as for the policymakers to redefine the urban policies.
    Type of Medium: Online Resource
    Pages: XI, 147 p. 60 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031280054
    Series Statement: SpringerBriefs in Geography,
    DDC: 307.76
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Oncology. ; Immunology. ; Metastasis. ; Cytology. ; Cancer Biology. ; Oncology. ; Immunology. ; Metastasis. ; Cell Biology.
    Description / Table of Contents: Chapter 1. A Systemic View of Metastatic Disease: Inter-organ Crosstalk and Therapeutic Implications -- Part I. Systemic Regulation in Metastatic Disease -- Chapter 2. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles -- Chapter 3. Bone Metastasis: Systemic Regulation and Impact on Host -- Chapter 4. Targeting Metastatic Disease: Challenges and New Opportunities -- Part II. Cachexia: A Debilitating Systemic Effect of Cancer -- Chapter 5. Signaling Pathways That Promote Muscle Catabolism in Cachexia -- Chapter 6. The Role of Interleukin-6 Cytokines in Cancer Cachexia -- Chapter 7. NF-kB Signaling in the Macroenvironment of Cancer Cachexia -- Part III. Therapy-induced Muscle Wasting -- Chapter 8. Therapy-induced Toxicities Associated with the Onset of Cachexia -- Chapter 9. Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy -- Part IV. Preventing and Targeting Cachexia in Cancer -- Chapter 10. New Developments in Targeting Cancer Cachexia -- Chapter 11. Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer.
    Abstract: This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.
    Type of Medium: Online Resource
    Pages: VI, 203 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031095184
    DDC: 571.978
    Language: English
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  • 15
    Keywords: Cancer. ; Metastasis. ; Lymphatics. ; Cancer Biology. ; Metastasis. ; Lymphatic System.
    Description / Table of Contents: Section 1: Genetic and Molecular Pathways of Cancer Growth and Metastasis -- Chapter 1. Hallmarks of Cancer: Molecular Underpinnings -- Chapter 2. Unifying concept of genomic changes: The mutational landscape of cancers -- Chapter 3. Tumor Microenvironment: Coconspirator in Tumorigenesis -- Chapter 4. Hallmarks of Metastasis: Molecular Underpinnings -- Chapter 5. Hereditary Cancer Syndromes and Cancer Metastasis -- Section 2: Pathology of Cancer Growth and Metastasis -- Chapter 6. Pathologic Assessment of Lymph Node Metastasis -- Chapter 7. Pathologic Assessment of Systemic or Distant Metastasis -- Chapter 8. The Role of Angiotropic Extravascular Migratory Metastasis in Metastases -- Section 3: Dormant Cancer Cells and their Reactivation in the Host Cancer Microenvironment -- Chapter 9. Tumor Dormancy and Relapse Regulated by the Extracellular Matrix -- Chapter 10. Therapy-Induced Dormancy and Residual Disease -- Section 4: The Microenvironment of Site-Specific Metastasis - Isaac P. Witz -- Chapter 11. The Microenvironment of Site-Specific Metastasis -- Section 5: Circulating Cancer Cells and Liquid Biopsy -- Chapter 12. Circulating tumor cells and ctDNA in sarcomas -- Chapter 13. Liquid biopsy using cell-free tumor DNA for gastrointestinal cancers -- Chapter 14. Circulating tumor cells and ctDNA in prostate cancer.-Chapter 15. Circulating Tumor Cells in Lung Cancer -- Chapter 16. CTCs/ ctDNA and Brain Metastasis.-Chapter 17. Epigenetics and liquid biopsy in oncology: role in metastasis and clinical utility -- Chapter 18. Metabolic reprogramming of circulating tumor cells for metastasis -- Section 6: Lymphatic System and Cancer Metastasis -- Chapter 19. Lymphatic System Biology, Pathobiology, and Relation to Cancer Metastasis -- Chapter 20. Lymphatic Specification and Development, EMT-MET, and Cancer Spread -- Chapter 21. Lymphangiogenesis, Lymph Nodes, Cancer Lymphangiogenesis and Metastasis -- Chapter 22. Immune cell trafficking in the lymphatics, hyaluronan biology and tumour metastasis -- Chapter 23. Lymphvascular Genomics and Proteomics, Clinical Syndromes, and Cancer Metastasis -- Chapter 24. Imaging of the Lymphatic System with Relevance to Cancer and Cancer Metastasis -- Chapter 25. Lymphedema: general pathophysiology, prevention and management in invasive cancer -- Section 7: Radiological Imaging of Early Cancer and Cancer Metastases -- Chapter 26. Primary Tumor Staging and Detection of Common Sites of Distant Metastatic Disease -- Chapter 27. Imaging Modalities in the Detection and Diagnosis of Metastatic Disease -- Chapter 28. Imaging of Bone Metastases -- Chapter 29. Imaging of Lung and Soft Tissue Metastases -- Chapter 30. Image-Guided Biopsy and Intervention for Metastatic Disease -- Section 8: Sentinel Lymph Node Surgery for Solid Cancer. Chapter 31. Sentinel Lymph Node Biopsy for Primary Cutaneous Malignancy -- Chapter 32. Sentinel Lymph Node Biopsy in Breast Cancer -- Chapter 33. Sentinel node navigation surgery for upper gastrointestinal cancer -- Chapter 34. Sentinel Lymph Node Mapping in Non-Small Cell Lung, Colon, and Thyroid Carcinomas -- Section 9: Surgical Treatment of Primary and Metastatic Cancer -- Chapter 35. The efficacy and evolution of surgical management based on cancer biology -- Chapter 36. The role of surgery in managing primary and metastatic melanoma -- Chapter 37. The Role of Surgery in Managing Primary and Metastatic Breast Cancer -- Chapter 38. The role of surgery in managing primary and metastatic colorectal cancer -- Chapter 39. The Role of Surgery in Management of Gastric Cancer -- Chapter 40. The role of surgery in managing primary and metastatic hepatopancreaticobiliary cancers -- Section 10: Cancer Metastasis to the Lung -- Chapter 41. Metastatic disease of the lung -- Section 11: Cancer Metastasis to the Liver -- Chapter 42. Tumor Resection and Ablation as a Means of Controlling Hepatic Metastases -- Chapter 43. Regional Arterial Infusional Therapy as a Means of Controlling Hepatic Metastases -- Section 12: Cancer Metastasis to the Bone -- Chapter 44. Molecular Mechanisms of Metastasis to the Bone.-Chapter 45. Surgical Management of Metastatic Disease to the Upper Extremity -- Chapter 46. Surgical Management of Metastatic Disease to the Lower Extremity -- Chapter 47. Surgical management of metastatic disease to the pelvis -- Chapter 48. Surgical Management of Metastatic Disease to the Spine -- Chapter 49. Interventional radiology techniques for management of skeletal metastases -- Section 13: Cancer Metastasis to the Brain and the Nervous System -- Chapter 50. Brain Metastases: Overview and Molecular Mechanisms -- Chapter 51. Indications and Techniques for Surgical Intervention in Patients with Metastatic Brain Tumors -- Chapter 52. Brain Metastases: Current and Future pharmacological treatment -- Chapter 53. Radiotherapy for CNS Metastases -- Chapter 54. Leptomeningeal Carcinomatoses -- Section 14: Urologic Cancer and 1st Patterns of Metastasis -- Chapter 55. Urologic Cancer and 1st Patterns of Metastasis -- Section 15: Biology and Clinical Aspects of Sarcoma Progression -- Chapter 56. Soft Tissue Sarcoma -- Chapter 57. Bone Sarcoma -- Chapter 58. Liposarcoma Metastasis -- Chapter 59. Desmoid Tumors.-Chapter 60. Atypical patterns of metastases: How do Sarcoma’s metastasize? -- Chapter 61. Tumor Immune Microenvironment of Soft Tissue Sarcoma -- Section 16: The Role of Radiation in the Treatment of Primary and Metastatic Cancer -- Chapter 62. Basic Principles of Radiobiology and Cancer Metastasis Prevention -- Chapter 63. Technical Innovations in the Delivery of Radiation Therapy -- Chapter 64. Radiation Therapy in the Definitive Treatment of Cancer -- Chapter 65. Radiation Therapy for Extracranial Oligometastatic Disease -- Chapter 66. Spine Radiotherapy -- Section 17: Immunotherapy of Solid Malignancies -- Chapter 67. Immunotherapy in Melanoma and Merkel Cell Cancer -- Chapter 68. Landscape of Immunotherapy in Lung Cancer -- Chapter 69. Immuno-oncologic Treatment of Genitourinary Malignancies -- Section 18: Current Topics -- Chapter 70. Personalized Systemic Cancer Therapy -- Chapter 71. Cancer Stem Cells and Their Role in Metastasis -- Chapter 72. HPV Induced Cancers -- Chapter 73. Microbiome and Cancer Metastasis -- Chapter 74. Application of Artificial Intelligence in Research on Cancer and Its Metastasis.
    Abstract: This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. .
    Type of Medium: Online Resource
    Pages: XXIV, 806 p. 145 illus., 106 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030930844
    DDC: 571.978
    Language: English
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  • 16
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Tumor markers. ; Non-coding RNA. ; Cancers. ; Tumour Biomarkers. ; Non-coding RNAs.
    Description / Table of Contents: Chapter 1. The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective -- Chapter 2. Circulating MicroRNAs as Cancer Biomarkers in Liquid Biopsies -- Chapter 3. Regulation of Immune Cells by MicroRNAs and MicroRNA-Based Cancer Immunotherapy -- Chapter 4. Machine-Learning-Based Methods and Best Practices of MicroRNA-Target Prediction and Validation -- Chapter 5. Turning Data to Knowledge: Online Tools, Databases and Resources in MicroRNA Research -- Chapter 6. Bioinformatics Methods for Modeling MicroRNA Regulatory Networks in Cancer -- Chapter 7. Analysis of the p53/MicroRNA Network in Cancer -- Chapter 8. Machine Learning Using Gene-Sets to Infer miRNA Function -- Chapter 9. miRNA:miRNA Interactions: A Novel Mode of miRNA Regulation and Its Effect on Disease -- Chapter 10. ClustMMRA v2: A Scalable Computational Pipeline for the Identification of MicroRNA Clusters Acting Cooperatively on Tumor Molecular Subgroups -- Chapter 11. 3D Modeling of Non-coding RNA Interactions.
    Abstract: This book provides an update on the latest development in the field of microRNAs in cancer research with an emphasis on translational research. Since the early 2000s, microRNAs have been recognized as important and ubiquitous regulators of gene expression. Soon it became evident that their deregulation can cause human diseases including cancer. This book focuses on the emerging opportunities for the application of microRNA research in clinical practice. In this context, computer models are presented that can help to identify novel biomarkers, e.g. in circulating microRNAs, and tools that can help to design microRNA-based therapeutic interventions. Other chapters evaluate the role of microRNAs in immunotherapy, immune responses and drug resistance. Covering key topics on microRNAs in cancer research this book is a valuable resource for both emerging and established microRNA researchers who want to explore the potential of microRNAs as therapeutic targets or co-adjuvants in cancer therapies.
    Type of Medium: Online Resource
    Pages: VII, 317 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031083563
    Series Statement: Advances in Experimental Medicine and Biology, 1385
    DDC: 571.978
    Language: English
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  • 17
    Keywords: Cancer. ; Cytology. ; Clinical biochemistry. ; Cancer Biology. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.
    Abstract: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: X, 494 p. 40 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030997083
    Series Statement: Biology of Extracellular Matrix, 11
    DDC: 571.978
    Language: English
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  • 18
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Criminology. ; Urban policy. ; Geographic information systems. ; Urban Sociology. ; Criminology. ; Urban Policy. ; Geographical Information System.
    Description / Table of Contents: Editorial -- Part 1: Multidisciplinarity in theory and education -- Plural security: Diverse disciplines, multiple actors -- Third Generation CPTED – Integrating crime prevention and neighbourhood liveability -- Social work and policing: Multidisciplinary vocational trainings for urban security -- From the borders and edges: Youth cultures, arts, urban areas and crime prevention -- Part 2: Multidisciplinarity in policy and planning -- Standardisation and multidisciplinary processes in urban crime prevention. The only crime prevention standard in Europe since the Roman Empire: From the CEN 14383 series to the worldwide ISO 22341:2021 -- Local safety contracts: Profiling a multi-disciplinary and multi-level cooperation for crime prevention -- Beyond simplicity – Urban security as a diverse and transdisciplinary approach -- The quarter as new level of urban crime prevention -- Part 3: Multidisciplinary in research and practice -- Multidimensionality in geospatial urban crime prevention modelling and decision support: The case of Porto, Portugal -- Incivilities in public spaces and insecurity. A case study in Bologna, Italy -- The role of the perception of fear in the disintegration of neighbourhoods and the appearance of crime -- CPTED evolution, from Latin America to the World -- Make the World yours! Arts-based research in action in the Cerco do Porto neighbourhood -- ‘A revolution without death’. Hip-hop as a weapon against violence.
    Abstract: This book provides an original cross-thematic and wide scope review of crime prevention processes in urban areas that are explicitly based on the cooperation between different scientific and professional fields. Focusing primarily on environmental and community-based crime prevention, this book compiles a peer-reviewed collection of papers and prospective essays that explore how, and to what extent, multi-disciplinarity can be used as a cornerstone for achieving safer cities. Relying on the input from specialists, researchers, decision-makers, and practitioners from around the world, it covers the various stages from theory to implementation, by discussing theoretical stances, interpreting policy and planning guidelines, uncovering unique educational experiences, and narrating insights and lessons learned from innovative research and practice. Hence, it provides vivid discussions and invaluable insights into processes of partnership building, planning, and management, oriented towards establishing successful mechanism for preventing crime and reducing feelings of insecurity in urban areas.
    Type of Medium: Online Resource
    Pages: XIV, 352 p. 55 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031151088
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 19
    Keywords: Urban policy. ; Technology Sociological aspects. ; Information technology. ; Political science. ; Science Social aspects. ; Urban Policy. ; Information and Communication Technologies (ICT). ; Governance and Government. ; Science and Technology Studies.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. E-government: The Role of ICTs in Support of Public Administration’s Processes -- Chapter 3. e-Democracy: The Role of ICTs in Support of Citizens Participation -- Chapter 4. Technologies that Encourage Citizen e-Participation in Urban Governance -- Chapter 5. Digital Participatory Platforms as a Tool to Satisfy Local Government and Citizen’s Needs -- Chapter 6. International Best Practices -- Chapter 7. Focus on the Italian Context -- Chapter 8. MiraMap: A Digital Participatory Platform for Urban Regeneration -- Chapter 9. An Evaluation of Success and Failure of Digital Participatory Platform in Urban Regeneration Governance -- Chapter 10. Conclusion. The Way Forward.
    Abstract: This book deals with the issue of Digital Participatory Platforms (DPPs) for urban governance. It explains the role and potential that ICTs play in the decision-making processes of the Public Administration and citizens' participation. The book also illustrates the main technologies that encourage innovation and social inclusion, with particular focus on use of DPPs in urban regeneration programs and projects. It presents international best practices from local to European level and it describes the process of creation, development and testing of a DPP project with reference to the Italian case. The book is divided into three parts: the first one gives a framework of neighborhood urban and civic engagement through ICTs, studying in depth the role of ICTs in support of Public Administration’s processes and citizens participation; the second part investigates the topic of Digital Participatory Platforms (DPPs) with the description of their potentialities, the presentation of some international best practices and a specific focus on the Italian context; the third part draws the conclusions of this path by asking which are the main challenges in the adoption of Digital Participatory Platforms, in order to increase citizen participation and collaboration via technology.
    Type of Medium: Online Resource
    Pages: XVII, 138 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030977559
    Series Statement: Local and Urban Governance,
    DDC: 307.76
    Language: English
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  • 20
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Urban policy. ; Sociology, Urban. ; Geography. ; Human geography. ; Urban Policy. ; Urban Sociology. ; Regional Geography. ; Human Geography.
    Description / Table of Contents: Introduction -- The elements of urban form -- The agents and processes of urban transformation -- Cities in history -- Contemporary cities -- The study of urban form: Different approaches -- From theory to practice -- Relationships with other fields of knowledge -- Conclusions.
    Abstract: 'This is a textbook about cities or, more precisely, about the physical form of cities. It provides an overview of the main elements of urban form—streets, street blocks, plots and buildings—structuring our cities and the fundamental agents and processes of transformation shaping these elements. It applies this analytical framework to describe the evolution of cities over history as well as to explain the functioning of contemporary cities. After the initial focus on the 'object' (cities), the book introduces how different schools of thought have been dealing with this object since the emergence of Urban Morphology, as the science of urban form, in the turning to the twentieth century. Finally, the book identifies the main contributions of urban morphology to cities, societies and economies. This second edition of the book offers updated and more accurate knowledge on several morphological issues, presents expanded contents, and it has a more explicit didactic nature, including a set of exercises in the end of each chapter, that will help teachers and students (in architecture, geography, planning, history, sociology and urban studies) in acquiring and consolidating their urban morphological knowledge.
    Type of Medium: Online Resource
    Pages: XXV, 240 p. 95 illus., 70 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030924546
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 21
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Human geography. ; Design. ; Urban Sociology. ; Human Geography. ; Design.
    Description / Table of Contents: Introduction: Is public social life in decline and are contemporary masterplanning And public space design practices to be blamed?- Theorisation of informal public social life and interaction in urban public space -- The sociality and spatiality of social encounters among strangers -- Observations on the theorized conditions that support informal social interactions in new designed public spaces -- Observations on the under-theorized conditions that support informal social -- Interactions in new designed public spaces -- ‘Fourth-places’: The contemporary public settings for informal social life and Interaction.
    Abstract: This book challenges current views that public life is in decline and that contemporary urban design trends reliant on privatisation, control, events, and thematic designs are to be blamed. Drawing on detailed and extensive analysis of a case study that illustrates well such urban design trends, it shows that informal social life and interaction occur more than its necessary in new master planned environments and new designed public settings, whether public or private owned and/or managed. Furthermore, it reveals the existence of a new category of informal public social settings which it calls fourth places because of their close relationship to Oldenburg’s third places in terms of social and behavioural characteristics – radical departure from the routines of home and work, inclusivity and social comfort – but distinct in terms of activities, locations and spatial conditions – being characterised by spatial, temporal and managerial in-betweenness, i.e. indeterminacy in form, function and times, and a great sense of publicness. The acceptance of these findings problematises well-established urban design theories about master planning, expands existing social theories about the optimal conditions for public social life by empirically and spatially elaborating on them and redefines several spatial concepts for designing public space in relation to the specific dynamics of informal social interaction. More importantly, it brings optimism to urban design practice, offering new insights into designing more lively and inclusive public spaces.
    Type of Medium: Online Resource
    Pages: XVII, 237 p. 135 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031079467
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 22
    Keywords: Cancer. ; Biochemical markers. ; Microfluidics. ; Pharmacology. ; Cancer Treatment. ; Cancer Biology. ; Biomarkers. ; Microfluidics. ; Pharmacology. ; Cancer Therapy.
    Description / Table of Contents: Part 1. Fundamentals of Microfluidics and Biosensors -- Chapter 1. Fundamentals of Biosensors and Detection Methods -- Chapter 2. How to Get Away with Gradients -- Chapter 3. Sensors and Biosensors in Organs-on-a-chip Platforms -- Chapter 4. Current Trends in Microfluidics and Biosensors for Cancer Research Applications -- Part 2. Modelling the Tumor Microenvironment and Its Dynamic Events -- Chapter 5. The Tumor Microenvironment — an Introduction for the Development of Microfluidic Devices -- Chapter 6. Biomaterials for Mimicking and Modelling Tumor Micro-environment -- Chapter 7. Advancing Tumor Microenvironment Research by Combining Organs-on-chips and Biosensors -- Chapter 8. Microfluidic-driven Biofabrication and the Engineering of Cancer-like Microenvironments -- Chapter 9. Advances in 3d Vascularized Tumor-on-a-chip Technology -- Part 3. Cancer Detection and Diagnosis -- Chapter 10. Biosensors Advances: Contributions to Cancer Diagnostics and Treatment -- Chapter 11. Flexible Sensing Systems for Cancer Diagnostics -- Chapter 12. Coupling Micro-physiological Systems and Biosensors for Improving Cancer Biomarkers Detection -- Chapter 13. Microfluidic Biosensor-based Devices for Rapid Diagnosis and Effective Anti-cancer Therapeutic Monitoring for Breast Cancer Metastasis -- Chapter 14. Liquid Biopsies: Flowing Biomarkers -- Chapter 15. From Exosomes to Circulating Tumor Cells: Using Microfludics to Detect High Predictive Cancer Biomarkers -- Chapter 16. Microfluidics for the Isolation and Detection of Circulating Tumor Cells -- Chapter 17. Evolution in Automatized Detection of Cancer Cells: Advances in Magnetic Microcytometers -- Chapter 18. Droplet-based Microfluidic Chip Design, Fabrication and Use for Ultrahigh-throughput DNA Analysis and Quantification -- Chapter 19. Emerging Microfluidic and Biosensor Technologies for Improved Cancer Theranostics -- Part 4. Clinical Applications: Towards Personalized Medicine -- Chapter 20. Microfluidics for Cancer Biomarker Discovery, Research and Clinical Application -- Chapter 21. Methods for the Detection of Circulating Biomarkers in Cancer Patients -- Chapter 22. Advances in Microfluidics for the Implementation of Liquid Biopsy in Clinical Routine.
    Abstract: This book offers a comprehensive overview of the development and application of microfluidics and biosensors in cancer research, in particular, their applications in cancer modeling and theranostics. Over the last decades, considerable effort has been made to develop new technologies to improve the diagnosis and treatment of cancer. Microfluidics has proven to be a powerful tool for manipulating biological fluids with high precision and efficiency and has already been adopted by the pharmaceutical and biotechnology industries. With recent technological advances, particularly biosensors, microfluidic devices have increased their usefulness and importance in oncology and cancer research. The aim of this book is to bring together in a single volume all the knowledge and expertise required for the development and application of microfluidic systems and biosensors in cancer modeling and theranostics. It begins with a detailed introduction to the fundamental aspects of tumor biology, cancer biomarkers, biosensors and microfluidics. With this knowledge in mind, the following sections highlight important advances in developing and applying biosensors and microfluidic devices in cancer research at universities and in the industry. Strategies for identifying and evaluating potent disease biomarkers and developing biosensors and microfluidic devices for their detection are discussed in detail. Finally, the transfer of these technologies into the clinical environment for the diagnosis and treatment of cancer patients will be highlighted. By combining the recent advances made in the development and application of microfluidics and biosensors in cancer research in academia and clinics, this book will be useful literature for readers from a variety of backgrounds. It offers new visions of how this technology can influence daily life in hospitals and companies, improving research methodologies and the prognosis of cancer patients.
    Type of Medium: Online Resource
    Pages: XIX, 590 p. 100 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031040399
    Series Statement: Advances in Experimental Medicine and Biology, 1379
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Urban policy. ; Geographic information systems. ; Landscape architecture. ; Political science. ; Urban Policy. ; Geographical Information System. ; Landscape Architecture. ; Governance and Government.
    Description / Table of Contents: Chapter 1. Introduction (Jiří Pánek) -- Chapter 2. Geoparticipation and Democratic Theory (Jakub Bakule) -- Chapter 3. Geospatial Technologies For Geoparticipation (Jaroslav Burian, Jiří Pánek and Vít Pászto) -- Chapter 4. Open Data And Its Role In Geoparticipation (Jaroslav Burian and Barbora Kočvarová) -- Chapter 5. Improving Local Democracy Works: Determinants of Participatory Local Governments (Jakub Lysek) -- Chapter 6. Participatory Budgeting in the Czech Republic (Jiří Chovaneček) -- Chapter 7. GeoParticipatory tools in action: Case study Jeseník, Czech Republic (David Žichovský, Jiří Pánek, Jiří Chovaneček) -- Chapter 8. The Application Of City-Building Games In Spatial Planning (Jan PIŇOS, Jaroslav Burian).
    Abstract: The book explores the key factors affecting the successful implementation of public participation spatial systems in participatory planning as part of the urban governance system. It brings insight from nation-wide research in the Czech Republic and the implications to other countries in the region and beyond. The main aim of the proposed book is to analyse the state-of-the-art of using geoparticipatory tools for citizens’ participation in community decision-making process and to suggest the effective implementation of the geoparticipatory tools available in urban governance. This book explores the situation in the Czech Republic as a representative of for Eastern Bloc country, three decades after the political transition, on its way to public participation in local and urban governance. The active involvement of the citizens into the local and urban decision making process via geoparticipatory spatial tools is becoming a popular research field among human geographers, behavioural geographers, GIS scientists, environmental psychologists, policy scientists and many others scientific areas.
    Type of Medium: Online Resource
    Pages: IX, 188 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031055478
    Series Statement: Local and Urban Governance,
    DDC: 307.76
    Language: English
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  • 24
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Biophysics. ; Cell interaction. ; Cytology. ; Cancer Microenvironment. ; Mechanobiological Cell Signaling. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 191 p. 31 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030471897
    Series Statement: Advances in Experimental Medicine and Biology, 1270
    DDC: 571.978
    Language: English
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  • 25
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Genetics. ; Molecular biology. ; Cancer Biology. ; Genetics and Genomics. ; Molecular Biology.
    Description / Table of Contents: 1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies.
    Abstract: Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.
    Type of Medium: Online Resource
    Pages: XVII, 167 p. 72 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030756994
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cell death. ; Cancer Biology. ; Cell Death.
    Description / Table of Contents: Preface -- Introduction -- The intersection of anoikis resistance and fatty acid metabolism in cancer -- Anoikis resistance in melanoma -- Anoikis mediated by stress-activated MAPK signaling pathways -- Metabolic Regulation of Anoikis -- Metabolic Reprogramming contributes to Anoikis resistance in Cancer Cells -- Role of the nuclear receptors in anoikis -- The roles of anoikis in cervical cancer -- Shc and the control of small GTPase dynamics in cellular anchorage -- Anoikis and the Human Gut Epithelium in Health and Disease -- Epithelial cell extrusion: the prelude to anoikis -- Microtubule modifications and mitochondria: role in anoikis.
    Abstract: This book provides a useful resource for graduate-level cancer cell biology courses. Since the first report, in 1994, of “anoikis”—the apoptosis that occurs when cells lack appropriate contact with the extracellular matrix—over 2,100 papers have been published on this subject. This book is the first comprehensive, in-depth and up-to-date compendium on anoikis. Chapters are authored by some of the leading researchers in the field. This book provides both mechanistic and translational information regarding anoikis, in a convenient format. Mechanistically, the following topics will be addressed in detail: The role of MAP kinase signaling The role of Shc proteins as cellular anchorage sensors The role of cellular metabolism, and fatty acid metabolism in particular, and how they are affected by oncogenic transformation How epithelial cell extrusion – the prelude to anoikis—is regulated in normal and cancer cells The convergence of TGF-b and androgen receptor signaling in the regulation of anoikis This book also discusses the specialized functions and dysregulation of anoikis in the following cancer settings: Colon cancer Melanoma Cervical cancer The book serves to update i nvestigators actively working on problems in the anoikis field, in either experimental or translational settings. For investigators encountering novel biological phenomena that might relate to anoikis, it serve as an entry point to the literature that does not require an extensive background in cell adhesion signaling or apoptosis mechanisms. .
    Type of Medium: Online Resource
    Pages: VIII, 202 p. 6 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030738563
    DDC: 571.978
    Language: English
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  • 27
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Cancer Biology. ; Medical Microbiology. ; Biomedical Research. ; Human Physiology. ; Immunology.
    Description / Table of Contents: Chapter 1: The Microbiome And The Hallmarks Of Cancer -- Chapter 2: Microbiome In Human GI Cancers -- Chapter 3: The Gut Microbiome And Colorectal Cancer -- Chapter 4: Salmonella Infection In Human Cancers -- Chapter 5: Biomarkers Of Esophageal Cancers And Precancerous Lesions -- Chapter 6: Epithelial And Immune Cell Responses To Helicobacter Pylori That Shape The Gastric Tumor Microenvironment -- Chapter 7: Microbiome And Liver Cancer -- Chapter 8: THE MICROBIOME AND UROLOGIC CANCERS -- Chapter 9: Role Of Infections And Tissue Inflammation In The Pathology Of The Fallopian Tube And High-Grade Serous Ovarian Cancer -- Chapter 10: Commensal Microbes And Their Metabolites: Influence On Host Pathways In Health And Disease -- Chapter 11: Dietary And Microbiome In Cancer Prevention -- Chapter 12: Autophagy And Cancer-Current Biology And Drug Development -- Chapter 13: Mitochondrial Regulation Of Inflammation In Cancer -- Chapter 14: Modern Germ-Free Study Designs And Emerging Static Housing Technology In A Growing ‘Human Microbiome’ Market -- Chapter 15: Machine Learning In Identification Of Disease-Associated Microbiota -- Chapter 16: Mediation Analysis Of Microbiome Data And Detection Of Causality In Microbiome Studies.
    Abstract: This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.
    Type of Medium: Online Resource
    Pages: XII, 509 p. 31 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030679514
    Series Statement: Physiology in Health and Disease,
    DDC: 571.978
    Language: English
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  • 28
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Sustainability. ; Property. ; Common law. ; Education. ; Urban Sociology. ; Sustainability. ; Common Property and Land Law. ; Education.
    Description / Table of Contents: Part 1: Objectives, Substantive Issues and Structure of This Book -- Chapter 1. Scientific, knowledgeable background and Book Architecture -- Part 2: Urban Informality Transitions in the Middle East’s Cities -- Chapter 2. Governance and Sustainability Transitions on Urban Informality -- Chapter 3. Urbanization and Informality in the Era of Globalization -- Chapter 4. The Paradigm of Urban Informality: Laws, Norms, and Practices -- Chapter 5. State, Society, Economy, and Housing Informality -- Chapter 6. Land Rights, Governance and Urban Informality -- Chapter 7. Spatial Divide, Marginality, Social Exclusion, Social Cohesion, and Urban Informality -- Part 3: Cross-Regional Scene -- Chapter 8. A Puzzle of Urban Sustainability Transitions on Urban Informality in Egypt -- Chapter 9. The Pockets of Urban Informality in Lebanon -- Chapter 10. Hills of Urban Informality in Greater Amman, Jordan -- Part 4: Epilogue -- Chapter 11. A Credible Future.
    Abstract: This book develops an analytical framework for a serious investigation of the historical specificities of cities of the Global South within three Mediterranean areas and inland territories. Its starting point is the research on urban informality in three different environments; one has experienced tremendous socio-economic transformation, while the other two have experienced the conflict that occurred in the Middle East under a free-market-oriented imposed system. The book provides a unique overview of urban informality within the region. This book draws upon experience and intensive work on the definitions and taxonomies of urban informality in the Global South. It investigates urban informality as a site of transitions in different socioeconomic, socio-spatial, and political contexts, concerning theories and practice, to strengthen understanding of sustainable transition processes. It explores how urban informality operates in the context of comparative cross-national perspectives that meet the SDGs and the NUA. The book enables policymakers, planners, and designers to think about urban informality as a dynamic multi-dimensional phenomenon, or as a site of transitions, within a built environment embedded in specific contexts. It arrives at the full package of resilient benefits provided by urban informality and even the different basic ways in which a better way of life can become manifest. This book opens a new scientific discussion between urban informality and sustainability transition perspectives, between conceptual and empirical, and between structural and practical. Geoffrey Payne, Geoffrey Payne and Associates It is often assumed that informality is simply the opposite of formality – a binary structure of opposites. However, the academic literature has exposed it as far more layered and complex than this and the analysis by Professor Soliman demonstrates convincingly and comprehensively, the multi-layered nature of urban informality in Egypt and the Middle East in general. Overlapping legal forms of land tenure and property rights, together with variations both within as well as between settlements, make it vital to understand this complexity in order that policies to address it are evidence based. This book offers a synopsis of urban informality in the Middle East, ongoing research on the governance of sustainability transitions and how to deal with urban informality in the context of sustainability transitions. This provides an essential foundation for understanding the complexity of informality, reasons why it exists, the positive as well as negative features and the options for reducing it. It is essential reading for all involved in addressing the issue in a region of the world where the relationship between formal and informal development of land and housing is critical to social and economic development.
    Type of Medium: Online Resource
    Pages: XXIII, 450 p. 56 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030689889
    DDC: 307.76
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. NMR-Based Metabolomics in Cancer Research -- 2. Capillary Electrophoresis–Mass Spectrometry for Cancer Metabolomics -- 3. Chemical Isotope Labeling LC-MS for Metabolomics -- 4. Single cell metabolomics by mass spectrometry imaging -- 5. Fatty Acid Metabolism and Cancer -- 6. Metabolomics of Gastric Cancer -- 7. HIF-1α metabolic pathways in human cancer -- 8. Regulation of glycolysis in head and neck cancer -- 9. Metabolomics of oral/head and neck cancer -- 10. Ion chromatography with mass spectrometry for metabolomic analysis -- 11. Methods of lipidomic analysis: Extraction, derivatization, separation and identification of lipids -- 12. Functional metabolomics and chemoproteomics approaches reveal novel metabolic targets for anti-cancer therapy -- 13. Metabolomics of glioma -- 14. Microbial metabolomics: From methods to translational applications -- 15. Advances in the study of N6-methyladenine in eukaryotes -- 16. NMR Based Metabolomics -- 17. Quantitative analysis of oncometabolite 2-hydroxyglutarate -- 18. Tracer-based Cancer Metabolomic Analysis -- 19. Mass spectrometry-based shotgun lipidomics for cancer research -- 20. Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry-based Metabolomics.
    Abstract: Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
    Type of Medium: Online Resource
    Pages: XV, 312 p. 80 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030516529
    Series Statement: Advances in Experimental Medicine and Biology, 1280
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Immunology. ; Cancer Biology. ; Immunology.
    Description / Table of Contents: 1. The role of targeted therapy in multiple myeloma -- 2. Lenalidomide -- 3. Pomalidomide -- 4. Mechanisms driving resistance to proteasome inhibitors bortezomib, carfilzomib and ixazomib in multiple myeloma -- 5. Daratumumab -- 6. Elotuzumab -- 7. Histone deacetylase inhibitors -- 8. Bone targeted therapies -- 9. New targeted therapies for multiple myeloma under clinical investigation.
    Abstract: Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.
    Type of Medium: Online Resource
    Pages: XVII, 154 p. 5 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030734404
    Series Statement: Resistance to Targeted Anti-Cancer Therapeutics, 22
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Notch signaling in prevention ant therapy: fighting cancer with a two-sided sword -- Transcription factor RBPJ as a molecular switch in regulating the Notch response -- Unraveling of Hidden Secrets: The tumour suppressor Lethal (2) giant discs (Lgd)/CC2D1, Notch Signaling and Cancer -- Notch and endometrial cancer -- Notch and Esophageal Squamous Cell Carcinoma -- Notch signaling and liver cancer -- Notch inHead and Neck Cancer -- Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis -- The impact of Notch signalingfor carcinogenesis and progression of non-melanoma skin cancer: lessons learned fromcancer stem cells, tumor angiogenesis, and beyond -- Notch Signaling in Thyroid Cancer -- The Relevance of Notch Signaling in Cancer Progression -- Notch Signaling and the Breast Cancer Microenvironment -- Notch pathway: a journey from notching phenotypes to cancer immunotherapy -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books -- Notch Signaling and Embryologic Development and Molecular Basis of Notch Signaling – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XVII, 228 p. 28 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030550318
    Series Statement: Advances in Experimental Medicine and Biology, 1287
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Cancer Microenvironment. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: 1. The Tumour Microenvironment and Circulating Tumour Cells: A partnership driving metastasis and glycan-based opportunities for cancer control -- 2. Dormancy in the Tumor Microenvironment -- 3. Tumor-associated tertiary lymphoid structures: A cancer biomarker and a target for next-generation immunotherapy -- 4. Studying the tumor microenvironment in zebrafish -- 5. Pre-metastatic niche formation by neutrophils in different organs -- 6. Tumor cell invasion and the tumor microenvironment: Special focus on brain tumors -- 7. The dog as a model to study the tumor microenvironment -- 8. EFFEROCYTOSIS AND THE STORY OF “FIND ME’’, ‘’EAT ME” AND “DON’T EAT ME” SIGNALING IN THE TUMOR MICRO ENVIRONMENT -- 9. Color-coded imaging of the tumor micro-environment (TME) in human patient-derived orthotopic xenograft (PDOX) mouse models -- 10. Mitochondria and the tumor microenvironment in blood cancer -- 11. Telocytes in the tumor microenvironment -- 12. Modeling the roles of astrocytes in the metastatic tumor cell microenvironment -- 13. Roles of fibroblasts in microenvironment formation associated with radiation-induced cancer -- 14. Tumor microenvironment-associated pericyte populations may impact therapeutic response in thyroid cancer -- 15. The adrenergic nerve network in cancer -- 16. Current treatment modalities targeting tumor microenvironment in castration-resistant prostate cancer -- 17.Brain metastases and tumor microenvironment -- 18. MIGRATION STIMULATING FACTOR (MSF). ITS ROLE IN THE TUMOUR -- MICROENVIRONMENT -- 19. Mechanical Signaling in the Mammary Microenvironment - from Homeostasis to Cancer -- 20. Osteopontin Signaling in Shaping Tumor Microenvironment Conducive to Malignant Progression -- 21. Progesterone receptor signaling in the breast tumor microenvironment -- 22. Progranulin/GP88, a complex and multi-faceted player of tumor growth by direct action and via the tumor microenvironmen -- 23. Sex-based differences in the tumor microenvironmet. .
    Abstract: This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 548 p. 79 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030731199
    Series Statement: Advances in Experimental Medicine and Biology, 1329
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Proteins . ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Protein Biochemistry. ; Internal Medicine.
    Description / Table of Contents: CCL2 in the tumor microenvironment -- CXCL3 signaling in the tumor microenvironment -- CXCL8 Signaling in the Tumor Microenvironment -- CXCL11 signaling in the tumor microenvironment -- CXCL12 signaling in the tumor microenvironment -- CXCL13 signaling in the tumor microenvironment -- CCL24 signaling in the tumor microenvironment -- CCL25 signaling in the tumor microenvironment -- CCL27 signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression, their regulation, and their roles in immune cell recruitment, as well as how they affect cancer immunity and tumorigenesis. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Chemokines – Part Bupdates us on what we know about various aspects of the tumor microenvironment, as well as apprises us on future directions in the field. This book is essential reading for advanced cell biology and cancer biology students as well as scientists seeking an update on recent developments and research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: IX, 139 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030626587
    Series Statement: Advances in Experimental Medicine and Biology, 1302
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. Defining breast cancer -- 2: Breast Cancer Recurrence and Survival -- 3: Synopsis of the Treatment of Breast Cancer -- 4: The Present Treatment of Hereditary Breast Cancer -- 5: Basis for the Epigenetic Treatment of Triple Negative Breast Cancer -- 6: A New Treatment Strategy foe BRCA1 Related Breast Cancer -- 7: Present Options in the Prevention of Breast Cancer -- 8: The Physiological Basis of Breast Cancer Prevention -- 9: The Present and Future of Screening in Breast Cancer Prevention -- 10: A Vision of the Future.
    Abstract: The objective of this book is to provide a critical analysis of the present prevention strategies for breast cancer, emphasizing the cost benefits and quality of life of the patient. Rooted in the present knowledge of breast cancer biology and prevention and treatment options, the book will describe the future tools that could be available to oncologists and how these new approaches may change the landscape of recurrence and survival of the disease. Special emphasis will be given to the prevention strategies counterposing the present limitations and conflicting prevention guidelines for both hereditary and preventive non-hereditary breast cancer, and propose how the implementation of new strategies based on the present knowledge could save millions of lives and be more cost efficient. The book will present a critical status of the treatment and prevention of breast cancer and detail how a quantum leap could be achieved in the field by applying present basic research knowledge to clinical application.
    Type of Medium: Online Resource
    Pages: XI, 192 p. 41 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030728151
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Metabolism. ; Cancer Treatment. ; Cancer Metabolism. ; Cancer Therapy. ; Cancer Biology.
    Description / Table of Contents: Part I. Basic Metabolism of Cancer Cells -- Glucose Metabolism in Cancer the Warburg effect and Beyond -- Glutamine Metabolism in Cancer -- The Heterogeneity of Lipid Metabolism in Cancer -- Part II. Heterogeneity of Cancer Metabolism -- The Multifaceted Glioblastoma: from Genomic Alterations to Metabolic Adaptions -- The Intricate Metabolism of Pancreatic Cancers -- The heterogeneity of breast cancer metabolism for therapy -- Non-Hodgkin Lymphoma Metabolism -- The Heterogeneity Metabolism of Renal Cell Carcinomas -- The Heterogeneity Metabolism of Liver Cancer -- Different Tumor Microenvironments Lead to Different Metabolic Phenotypes -- The Intratumoral Heterogeneity of Cancer Metabolism -- Cancer Stem Cells Metabolism -- Metabolism of Immune cells in the Tumor Microenvironment -- Part III. Relationship between Cancer Cells and Cancer-Associated Fibroblasts -- Metabolic Relationship between Cancer-Associated Fibroblasts and Cancer Cells -- Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts -- Part IV. The metabolic interplay between cancer and other diseases -- Diabetes and Cancer: the Epidemiological and Metabolic Associations -- Bridging the Metabolic Parallels between Neurological Diseases and Cancer -- Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy -- Index.
    Abstract: This open access volume will introduce recent discoveries in the field of cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, etc. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students. .
    Type of Medium: Online Resource
    Pages: XXIII, 271 p. 55 illus., 54 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030657680
    Series Statement: Advances in Experimental Medicine and Biology, 1311
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Tumors Immunological aspects. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Tumour Immunology. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: Interleukin-6 function and targeting in prostate cancer -- IL-7 signaling in the tumor microenvironment -- IL-10 Signaling in the Tumor Microenvironment of Epithelial Ovarian Cancer -- Targeted delivery of IL-12 adjuvants immunotherapy by oncolytic viruses -- IL-22 signaling in the tumor microenvironment -- IL-23 and the Tumor Microenvironment -- Interleukin (IL)-24: Reconfiguring the tumor microenvironment for eliciting antitumor response -- Interleukin-31, a potent pruritus-inducing cytokine and its role in inflammatory disease and in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment. Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-6, IL-7, IL-10, IL-12, IL-22, IL-23, and IL-24 signaling. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Interleukins – Part Bupdates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XII, 134 p. 23 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030556174
    Series Statement: Advances in Experimental Medicine and Biology, 1290
    DDC: 571.978
    Language: English
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    Keywords: Sociology, Urban. ; Ethnology. ; Culture. ; Arts. ; Cultural property. ; Urban Sociology. ; Regional Cultural Studies. ; Fine Art. ; Cultural Heritage.
    Description / Table of Contents: Structural Analysis and Safety Assessment of a Historic Hydraulic Structure in Egypt -- Stabilization and Strengthening Proposals for the Ancient Serapeum at Saqqara Using Advanced Composite Materials -- Trends of Contemporary Arts in Innovative Interior Architecture Design of Cultural Spaces -- Why does Revenge challenge conservators more than Avaton? -- Quest for Latent Habitats -- Travel Literature Illustrations and Topography and Their Role in Documenting the Islamic Arabic identification and the geopolitical alterations of Jerusalem city -- The Deep Ground: A Fourth Layer in Creative Cities that Represents Silent Identities -- Historic Urban Landscapes and Archaeological Sites: Perspectives and Directions -- Redeveloping the Historic Urban Ensemble: The Case of the King Abdulaziz Historic Centre, ArRiyadh Saudi Arabia -- The Influence of Public Art in Developing Chinese Urban Public Space: Current Trends and Future Directions -- Reviving the Historical Hajj Route in Old Jeddah.
    Abstract: This book covers a broad range of topics relating to architecture and urban design, such as the conservation of cities’ culture and identity through design and planning processes, various ideologies and approaches to achieving more sustainable cities while retaining their identities, and strategies to help cities advertise themselves on the global market. Every city has its own unique identity, which is revealed through its physical and visual form. It is seen through the eyes of its inhabitants and visitors, and is where their collective memories are shaped. In turn, these factors affect tourism, education, culture & economic prosperity, in addition to other aspects, making a city’s identity one of its main assets. Cities’ identities are constructed and developed over time and are constantly evolving physically, culturally and sociologically. This book explains how architecture and the arts can embody the historical, cultural and economic characteristics of the city. It also demonstrates how cities’ memories play a vital role in preserving their physical and nonphysical heritage. Furthermore, it examines the transformation of cities and urban cultures, and investigates the various new approaches developed in contemporary arts and architecture. Given its scope, the book is a valuable resource for a variety of readers, including students, educators, researchers and practitioners in the fields of city planning, urban design, architecture and the arts.
    Type of Medium: Online Resource
    Pages: XII, 238 p. 331 illus., 298 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030148690
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    DDC: 307.76
    Language: English
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    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling -- Overview of Basic Mechanisms of Notch Signaling in Development and Disease -- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate -- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling -- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster -- Molecular Regulation of Notch Signaling by Gremlin -- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex -- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss -- Insulin–dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation -- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF-κB and beyond -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XIII, 172 p. 32 illus., 31 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030364229
    Series Statement: Advances in Experimental Medicine and Biology, 1227
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: MicroRNAs in the tumor microenvironment -- The Impact of Estrogen in the Tumor Microenvironment -- The non-bone related role of RANK/RANKL signaling in cancer -- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment -- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma -- COX-2 Signaling in the Tumor Microenvironment -- Renin–angiotensin system in the tumor microenvironment -- Stem cell secreted factors in the tumor microenvironment -- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy -- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms -- Index.
    Abstract: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIV, 162 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030502249
    Series Statement: Advances in Experimental Medicine and Biology, 1277
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: The tumor microenvironment: focus on extracellular matrix -- Keratan Sulphate in the Tumour Environment -- Hyaluronan in the tumor microenvironment -- Fibronectin in the tumor microenvironment -- Matrix metalloproteinases role in tumor microenvironment -- Flipping the Molecular Switch: Influence of Perlecan and its Modifiers in the Tumor Microenvironment -- Heparan sulfate in the tumor microenvironment -- The role of Glypican-1 in the tumour microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components with the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newer generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book will be an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.
    Type of Medium: Online Resource
    Pages: XI, 181 p. 29 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030401467
    Series Statement: Advances in Experimental Medicine and Biology, 1245
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Medical microbiology. ; Cytology. ; Pediatrics. ; Cancer Biology. ; Medical Microbiology. ; Cell Biology. ; Pediatrics.
    Description / Table of Contents: The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies -- Genomics and the Immune Landscape of Osteosarcoma -- RECQ DNA Helicases and Osteosarcoma -- Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma -- Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma -- Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response -- Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: 2019 update -- The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets -- Autophagy in OS -- Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs -- Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment -- Comparative Immunology and Immunotherapy of Canine Osteosarcoma -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.
    Type of Medium: Online Resource
    Pages: XIII, 233 p. 34 illus., 23 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030430856
    Series Statement: Advances in Experimental Medicine and Biology, 1258
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.
    Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.
    Abstract: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
    Type of Medium: Online Resource
    Pages: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030345211
    Series Statement: Advances in Experimental Medicine and Biology, 1221
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Dermatology. ; Oncology. ; Cancer Biology. ; Dermatology. ; Oncology.
    Description / Table of Contents: Section I: Introduction -- Lessons learned from paleolithic models and evolution for human health: a snap shot on beneficial effects and risks of solar radiation -- Section II: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences (I) -- Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need? -- Section III: Solar radiation, Vitamin D and human health -- Vitamin D status and cancer incidence and mortality -- Vitamin D receptors polymorphisms and cancer -- On the relationship between sun exposure and all-cause mortality -- Lindqvist PG (2020) Women with greater sun exposure habits seem to be healthier and to live longer. Are these results in contrast to other research? No -- Section IV: Epidemiology of skin cancer -- Epidemiology of skin cancer and UV radiation – update 2019 -- Solar UV exposure and mortality from skin tumors: an update -- Solarium Use and Risk for Malignant Melanoma: many open questions,not the time to close the debate -- Section V: Photocarcinogenesis of skin cancer -- Molecular biology of basal and squamous cell carcinomas -- Human papillomaviruses and skin cancer -- The immune system and pathogenesis of melanoma and nonnmelanoma skin cancer -- Section VI: The relevance of the vitamin D endocrine system for skin cancer -- Protection from ultraviolet damage and photocarcinogenesis by vitamin D compounds -- The role of classical and novel forms of vitamin D in the pathogenesis and progression of non-melanoma skin cancers -- The Vitamin D Receptor as tumor suppressor in skin -- Cancer prevention in skin and other tissues via cross-talk between vitamin D- and p53- signalling -- Section VII: Prevention and Management of Skin Cancer -- Sunscreens in the United States: Current Status and Future Outlook -- A handful of sunscreen for whole body application -- Sunlight, vitamin D and Xeroderma pigmentosum -- Update: Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs) -- Section VIII: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences – II. promise and outlook -- Ultraviolet exposure scenarios: balancing risks of erythema and cutaneous vitamin D synthesis -- The Paleolithic nutrition model in relation to ultraviolet light and vitamin D -- Index.
    Abstract: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‑exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
    Type of Medium: Online Resource
    Pages: XIV, 428 p. 83 illus., 28 illus. in color. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030462277
    Series Statement: Advances in Experimental Medicine and Biology, 1268
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Biomechanics. ; Cancer Biology. ; Biomechanics.
    Description / Table of Contents: Metabolism in the tumor microenvironment -- Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment -- Viral hepatitis, inflammation, and tumour microenvironment -- Effects of HIV on the tumor microenvironment -- GLI2-mediated inflammation in the tumor microenvironment -- Stellate Cells in the Tumor Microenvironment -- Endothelial Progenitors in the Tumor microenvironment -- Chimeric antigen receptors for the tumour microenvironment -- Toll-Like Receptors (TLRs) in the Tumor Microenvironment (TME): A dragon-Like Weapon in a Non-Fantasy Game of Thrones -- Multiple dynamics in tumor microenvironment under radiotherapy -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research in the field. A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more. Taken alongside its companion volumes, Tumor Microenvironment: State of the Science updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 208 p. 28 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030445188
    Series Statement: Advances in Experimental Medicine and Biology, 1263
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Novel techniques to study the bone-tumor microenvironment -- An emerging model for cancer development from a tumor -- microenvironment perspective in mice and humans -- Effects of Exercise on the Tumour Microenvironment -- Effects of inhaled tobacco smoke on the pulmonary tumor microenvironment -- Multimodal molecular imaging of the tumour microenvironment -- Necrosis in the tumor microenvironment and its role in cancer recurrence -- The Multifaceted Effects of Autophagy on the Tumor Microenvironment -- The Sociobiology of Brain Tumors -- Tumor microenvironment conditioning by abortive lytic replication of oncogenic γ-herpesviruses -- The microbiome as a component of the tumor microenvironment -- Index.
    Abstract: This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment. Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XI, 160 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030357276
    Series Statement: Advances in Experimental Medicine and Biology, 1225
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Adipocytes in the tumour microenvironment -- Fibroblasts in the tumor microenvironment -- Mesenchymal stem cells in the tumor microenvironment -- Hepatic stellate cells in liver tumor -- Pancreatic stellate cells: The key orchestrator of the pancreatic tumor microenvironment -- Endothelial cells in the tumor microenvironment -- Lymphatic endothelial cell progenitors in the tumor microenvironment -- Oligodendrocyte progenitors in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor microenvironment.Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include fibroblasts, adipocytes, mesenchymal stem cells, stellate cells, and more. Taken alongside its companion volumes, Tumor Microenvironment: Non-Hematopoietic Cells updates us on what we know about the different aspects of the tumor microenvironment as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists focused in the tumor microenvironment and how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment. All of the chapter authors are renowned international experts in the cancer biology field in specific subfields that will be the focus of their chapters.
    Type of Medium: Online Resource
    Pages: X, 129 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030371845
    Series Statement: Advances in Experimental Medicine and Biology, 1234
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Human physiology. ; Medicine Research. ; Biology Research. ; Gynecology . ; Cancer Biology. ; Human Physiology. ; Biomedical Research. ; Gynecology.
    Description / Table of Contents: Preface -- PART 1: Basic Considerations -- Anatomy and Physiology of the Breast during Pregnancy and Lactation -- Diagnosis of Breast Disorders in Pregnancy and Lactation -- Clinical Presentations of Breast Disorders in Pregnancy and Lactation -- PART 2: Benign and Premalignant Disorders of the Breast in Pregnancy and Lactation -- Benign Disorders of the Breast in Pregnancy and Lactation -- Mastitis, Breast Abscess, and Granulomatous -- Premalignant disorders of the Breast in Pregnancy and Lactation -- PART 3: Breast Cancer in Pregnancy and Lactation -- Epidemiology of Pregnancy-Associated Breast Cancer -- Histology of Pregnancy-Associated Breast Cancer -- Clinical presentation, Diagnosis, and Prognosis of Pregnancy-Associated Breast Cancer -- . Treatment of Pregnancy-Associated Breast Cancer -- Special Clinical Situations -- Prenatal Care during and after Breast Cancer Treatment -- Lactation during and after Breast Cancer -- Pregnancy in Breast Cancer Survivors. Impact of Breast Cancer Treatment on Fertility -- Fertility Counseling and Preservation for Breast Cancer Patients -- Pregnancy after Breast Reconstruction -- Pregnancy and Lactation: Risk or Protective Factors for Breast Cancer -- Psychological Aspects of Pregnancy and Lactation in Patients with Breast Cancer.
    Abstract: Symptoms of the breast in gravid women commonly represent physiological changes, however they may also be related to serious underlying breast disease; this challenging dilemma is aggravated by diagnostic and therapeutic limitations imposed by safety issues regarding the mother and fetus. A comprehensive coverage of all aspects of normal and pathologic breast changes during pregnancy and lactation, their diagnosis and management is provided in the present work. The organized structure of this book begins with gestational changes of the breast, while discussing safety, hazards, and arguments regarding diagnostic approaches. It then goes on by describing various clinical presentations and common and uncommon benign disorders during gravidity. The book then addresses pre-malignant lesions of the breast, opening the dialogue on how to manage these confusing lesions in pregnant and nursing women. It continues toward pregnancy-associated breast cancer, focusing on every facet of the problem, including epidemiology, diagnosis, treatment and complications, anesthetic considerations, prenatal care, and rare malignancies; and comes to an end by arguing main psychological concerns. In the midst of this orderly sequence fertility issues, pregnancy, and breastfeeding in women who have overcome their breast cancer are also discussed. This unique reference has been written by academic experts from different centers and diverse disciplines in a practical format. It is intended to be an ideal resource for every practitioner and specialist who manages complaints of gravid and nursing women or treats breast disorders in women of child bearing age.
    Type of Medium: Online Resource
    Pages: XXV, 216 p. 55 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030415969
    Series Statement: Advances in Experimental Medicine and Biology, 1252
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Stem cells. ; Regenerative medicine. ; Cytology. ; Cancer Microenvironment. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Cell Biology.
    Description / Table of Contents: Elastin in the Tumor Microenvironment -- Decorin in the tumor microenvironment -- Syndecan-1 in the tumor microenvironment -- Versican in the tumor microenvironment -- Chondroitin Sulphate Proteoglycans in the Tumour Microenvironment -- Lipoproteins and the Tumor Microenvironment -- The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility -- Thrombospondin in Tumor Microenvironment -- Tenascin-C function in glioma: immunomodulation and beyond -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor microenvironment during cancer development. Furthermore, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include elastin, decorin, syndecan-1, versican, lipoproteins, brevican, thrombospondin, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part B updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapters authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.
    Type of Medium: Online Resource
    Pages: XIII, 178 p. 36 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030484576
    Series Statement: Advances in Experimental Medicine and Biology, 1272
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Immunology. ; Oncology. ; Cancer Biology. ; Immunology. ; Oncology.
    Description / Table of Contents: Overview of Basic Immunology and Clinical Application -- Advances in Diagnostic Procedures and their Applications in the era of Cancer Immunotherapy -- Immunotherapy for Melanoma -- Immunotherapy in Lung Cancer: From a minor God to the Olympus -- Immunotherapy in Gastrointestinal Malignancies -- Current Landscape of Immunotherapy in Genitourinary Malignancies -- Immuno-oncology for Gynecologic Malignancies -- Immunotherapy for Neuro-Oncology -- Immunotherapy and Radiation -- CAR T-cells -- Skin Reactions to Immune Checkpoint Inhibitors -- Gastrointestinal Tract Adverse Events -- Immune-Related Adverse Events: Pneumonitis -- Hepatobiliary Adverse Events -- Immune Checkpoint Inhibitors (ICIs) Related Cardiotoxicity -- Renal Toxicity -- Immune-Related Oral, Otologic and Ocular Adverse Events -- Cancer Imaging in Immunotherapy -- The Microbiome in Immuno-Oncology -- New developments in the use of Patient-reported outcomes in Cancer Patients undergoing Immunotherapies.
    Abstract: Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. The third edition of Immunotherapy is an updated overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. It explores the breath of immunotherapeutic strategies available to treat a wide range of cancers, from melanoma and non-small cell lung cancer to gastrointestinal, genitourinary, gynecologic and nervous system malignancies. With increasing use of checkpoint inhibitors as standard of care and in clinical trials, the challenges associated with their use undoubtedly increase. As objective response is limited to a subset of patients and is often associated with distinct immune related side effects that are potentially life threatening, it is essential to identify patients who are likely to respond to immunotherapy and those who are at a risk for developing treatment-related side effects. In the absence of a validated predictive biomarker, innovative technologies and assays are being used to identify critical biomarkers that drive the immune response. Hence, a chapter to provide a basic understanding of the diagnostic procedures has been included besides the chapter on the cellular components of the human immune system. This new edition will also inform readers on use of novel microbiome and imaging approaches. Finally, the book includes a chapter on patient-reported outcomes in patients treated with immunotherapies as the authors recognize the importance of including missing patient voice in clinical trials and longitudinal assessment of symptom reports. In short, the third edition of this book provides a comprehensive overview of the latest developments in the field of immune-oncology that will help health care professionals make informed treatment decisions. The book’s chapters are written by a diverse cast of experts conducting cutting-edge research, providing the reader with the most up-to-date science.
    Type of Medium: Online Resource
    Pages: XII, 339 p. 44 illus., 35 illus. in color. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030410087
    Series Statement: Advances in Experimental Medicine and Biology, 1244
    DDC: 571.978
    Language: English
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  • 50
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Stem cells. ; Cancer Biology. ; Biomedical Research. ; Biotechnology. ; Stem Cell Biology.
    Description / Table of Contents: Preface -- Introduction – Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs -- Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis -- Disseminated Tumor Cells and Dormancy in Breast Cancer Progression -- Methodology for the Isolation and Analysis of CTCs -- Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-derived Models for Drug Testing -- Circulating Tumor Cells (CTCs) Heterogeneity in Metastatic Breast Cancer: Different Approaches for Different Needs -- Relevance of CTC Clusters in Breast Cancer Metastasis -- Epigenetics of Circulating Tumor Cells in Breast Cancer -- Circulating Tumor Cells: Applications for Early Breast Cancer -- Clinical Relevance and Therapeutic Application of CTCs in Advanced Breast Cancer. .
    Abstract: This book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients. This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine. The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer.
    Type of Medium: Online Resource
    Pages: XV, 167 p. 15 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030358051
    Series Statement: Advances in Experimental Medicine and Biology, 1220
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Endocrinology. ; Pathology. ; Cancer Biology. ; Endocrinology. ; Pathology.
    Description / Table of Contents: 1. Biophysiology of the uterus: development, cyclic changes, menopause -- 2. Hormonal effects in reproductive technology (ovulation stimulation, in vitro fertilization) -- 3. Hormonal role and therapy in common benign uterine lesions: endometrial polyps, leiomyomas, adenomyosis -- 4. Endometrial hyperplasia; precancerous lesions of the endometrium. Hormone therapy -- 5. Endometrial Carcinoma. Endometriosis, Hormonal Role in Carcinogenesis. Hormonal Therapy -- 6. Menopausal Hormone Therapy. Contraceptives -- 7. Replacement hormone therapy for gender dysphoria and congenital sexual anomalies -- 8. Hormone therapy for endometrial neoplasia related to breast cancer therapy (Tamoxifen) -- 9. Endometrial histopatholigic changes in hormonal therapy (contraceptives, ovulation stimulation, hormone replacement therapy, hormonal antitumoral therapy).
    Abstract: Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of “natural” hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women’s health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women’s health. .
    Type of Medium: Online Resource
    Pages: VIII, 185 p. 66 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030384746
    Series Statement: Advances in Experimental Medicine and Biology, 1242
    DDC: 571.978
    Language: English
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    Keywords: Sociology, Urban. ; Urban economics. ; Urban Sociology. ; Urban Economics.
    Description / Table of Contents: The reform of Cohesion Policy in the 2014-2020 programming period and the regional smart specialization strategy -- Regions and Macro-regions in European Territorial Cooperation: present and 2021+ -- The urban question with the EU integration project. A continuous project of experimentation -- Innovation in EU “urban policy” during the 2014-2020 programming period: conceptions, experiences and perspectives -- Conclusions. .
    Abstract: The book critically reflects on some of the most important novelties and experimentations in the context of the European Union’s renewed urban and regional policy in the last programming period, 2014-2020. In particular, it examines four main innovations characterizing this period, which emerged as a result of the deep rethinking and reorganization of Cohesion Policy in the spirit of the place-based approach to local development, i.e. the development of the smart specialization strategy, the establishment of macro-regions, the focus on the urban dimension as a horizontal priority, and the role of social innovation in urban policy. Unlike other similar books, it analyzes the urban dimension of the reformed EU cohesion policy, especially focusing on its interplay with the regional dimension, and which has not been fully addressed to date. The book is intended for social scientists engaged in research on European issues, especially from regional and urban perspectives, policy-makers, particularly at the local level, and graduate students interested in regional and urban European matters.
    Type of Medium: Online Resource
    Pages: VI, 88 p. 5 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030345754
    Series Statement: PoliMI SpringerBriefs,
    DDC: 307.76
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Sports Sociological aspects. ; Economic geography. ; Political science. ; Urban Sociology. ; Sport Sociology. ; Economic Geography. ; Political Science.
    Description / Table of Contents: Foreword -- 1 Introduction -- 2. The Los Angeles Olympics 1932 -- 3 The Los Angeles Olympics 1984 -- 4 The Los Angeles Olympics 2028 -- 5 Similarities and differences between the three LA Olympics -- 6 Conclusionf: Legacies of the 2028 Olympics -- Index -- Acronyms. .
    Abstract: This open access book describes the three planning approaches and legacy impacts for the Olympic Games in one locale: the city of Los Angeles, USA. The author critically compares the similarities and differences of the LA Olympics by reviewing the 1932 and 1984 Olympics and by analyzing the concurrent planning process for the 2028 Olympics. The author unravels the conditions that make (or do not make) LA28’s argument “we have staged the Games before, we can do it again” compelling. Setting the bid’s promises into the contemporary local and global mega-event contexts, the author analyzes why LA won the bids, how those wins allowed LA to negotiate concessions with the IOC and NOC, and how legacies were planned, executed, and ultimately evolved. The author concludes with a prediction which 2028 legacy promises might and might not be fulfilled given the local and international Olympic contexts.
    Type of Medium: Online Resource
    Pages: XV, 60 p. 5 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030385538
    Series Statement: SpringerBriefs in Geography,
    DDC: 307.76
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Sustainable architecture. ; Sustainability. ; Economic development. ; Urban Sociology. ; Sustainable Architecture/Green Buildings. ; Sustainability. ; Development Studies.
    Description / Table of Contents: Part I. Environment, Perception and Design of the Built -- Chapter 1. An introduction (Mainak Ghosh) -- Part II. Environment and the Built: Earth as an Inspiration -- Chapter 2. A Place-making between Mountain and River: A General View on Dwelling culture and Architecture of the Indigenous Vernacular Villages in Indonesia (Indah Widiastuti) -- Chapter 3. Reflection on Rhetorics, Appropriate Building Materials and Domestic Utilities Towards Reduction of Housing Costs in Tanzania (Moses Felician Moses) -- Chapter 4. Sustainable Planning Interventions for Urban Crisis in respect to Outdoor Thermal Comfort-Case study of Kolkata (Debashish Das) -- Chapter 5. Traditional Houses of Cunda Island in Anatolia (Ayten Erdem) -- Part III. Perception and the Built: Eyes of the Mind -- Chapter 6. Regionalising Contemporary Architecture in West Sumatra (Feni Kurniati) -- Chapter 7. Hyderabad: A city with glorious past and flying future (Madhu Vottery) -- Chapter 8. Recife Fascinations (Rachael Carter) -- Chapter 9. Living in Alleys: A Story of Urban Kampong (Achmad Syaiful) -- Part IV: Design and the Built: Man the Place Maker -- Chapter 10. The ‘smart’ as a project for the city (V. Geropanta) -- Chapter 11. Urban Transformations of Residential Settlements in Colonial Towns: Case Study of Little Europe (Ruchira Das) -- Chapter 12. Evaluating and Comparing The Effectiveness of Subnational Policies Concerning Hurricane Evacuation Zones in Built Environment: Applicability of the State of Florida Model (Haris Alibasic) -- Chapter 13. Transformation of Commercial Centres and Urban Development Process in Global South (Sanghamitra Sarkar) -- Part V: Future of the Built -- Chapter 14. Future of the Built: A Holistic View, (Mainak Ghosh).
    Abstract: T his edited volume is a compilation of the ‘built environment’ in response to many investigations, analyses and sometimes mere observations of the various dialogues and interactions of the built, in context to its ecology, perception and design. The chapters concentrate on various independent issues, integrated as a holistic approach, both in terms of theoretical perspectives and practical approaches, predominantly focusing on the Global South. The book builds fabric knitting into the generic understanding of environment, perception and design encompassing ‘different’ attitudes and inspirations. This book is an important reference to topics concerning urbanism, urban developments and physical growth, and highlights new methodologies and practices. The book presumes an understanding unearthed from various dimensions and again woven back to a common theme, which emerges as the reader reads through. Various international experts of the respective fields working on the Global South contributed their latest research and insights to the different parts of the book. This trans-disciplinary volume appeals to scientists, students and professionals in the fields of architecture, geography, planning, environmental sciences and many more.
    Type of Medium: Online Resource
    Pages: XI, 580 p. 248 illus., 186 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030258795
    Series Statement: Springer Geography,
    DDC: 307.76
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Sustainability. ; Ethnology. ; Culture. ; Urban Sociology. ; Sustainability. ; Regional Cultural Studies.
    Description / Table of Contents: Introduction -- Modern Dreams. Modern Illusions – Ideas on Cooperativism -- Progress Through Architecture. Two Modernisms? -- How Does the Space Perform? -- Sensitive Urban Planning or Critical Spatial Practice? -- An Old or New Urban Issue? -- Workshop? Settlement House? Laboratory? -- Models of Urban Cultures -- ‘Total Pedagogisation’? -- State of Emergency and Everyday Life in Żoliborz.
    Abstract: This book discusses the unknown and remote urban experiment of modernist social practices and dreams of a better tomorrow. It describes the history of the Warsaw Housing Cooperative not as a historical relic or a single case study, but instead analyses this working-class social housing estate – in itself an extremely interesting emancipatory project – from the perspective of contemporary urban studies. It focuses on issues related to the power of architecture, architects and the estate residents themselves: the city's performative actions, problems related to the polycentric character of the city authorities, the opportunities of building urban institutions, and social identities and urban common goods. Inspired by the history of the Warsaw Housing Cooperative, the book investigates how the estate residents, assisted by social reformers (today called urban activists), organised the urban space of performative democracy, and how they developed anti-capitalist, urban-survival strategies and created new lifestyles. It also analyses how passive tenants turned into active citizens claiming their right to the city. The inspiring book is intended for researchers in the field of performative studies, urban sociologists, critical urban studies researchers, animators of social life and urban activists.
    Type of Medium: Online Resource
    Pages: XV, 292 p. 44 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030230777
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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    Keywords: Sociology, Urban. ; Sustainable architecture. ; Urban ecology (Biology). ; Landscape ecology. ; Urban Sociology. ; Sustainable Architecture/Green Buildings. ; Urban Ecology. ; Landscape Ecology.
    Description / Table of Contents: Part 1: Concepts -- Chapter 1. The Green City: general concept -- Chapter 2. The nature concept - of what the green consist of -- Chapter 3. The benefit concept - How people can benefit from urban nature -- Part 2: Challenges and Practices -- Chapter 4. Urban Parks -- Chapter 5. Urban Gardening -- Chapter 6. Urban Agriculture -- Chapter 7. Urban Forests -- Chapter 8. Urban waters and wetlands -- Chapter 9. Urban Protected Areas -- Chapter 10. Urban Biodiversity -- Chapter 11. Multi-functional urban green spaces -- Chapter 12. Conflicting nature in cities. .
    Abstract: This book shows what role nature can play in a city and how this can make it a better place for people to live. People, planners, designers and politicians are working towards the development of green cities. Some cities are already promoted as green cities, while others are on their way to become one. But their goals are often unclear and can include different facets. Presenting contributions from world leading researchers in the field of urban ecology, the editors provide an interdisciplinary overview of best practices and challenges in creating green cities. They show examples of how to build up these cities from bits and pieces to districts and urban extensions. Each example concludes with a summary of the collected knowledge, the learning points and how this can be used in other places. The best practices are collected from around the world – Europe, Australia, America and Asia. The new dynamic urban development of Asia is illustrated by case studies from China and the Indian subcontinent. The reader will learn which role nature can play in green cities and what the basic requirements are in terms of culture, pre-existing nature conditions, existing urban surroundings, history, design and planning. .
    Type of Medium: Online Resource
    Pages: IX, 532 p. 230 illus., 158 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030377168
    Series Statement: Cities and Nature,
    DDC: 307.76
    Language: English
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    Keywords: Sociology, Urban. ; Entrepreneurship. ; New business enterprises. ; Political science. ; Economic sociology. ; Education and state. ; Technological innovations. ; Urban Sociology. ; Entrepreneurship. ; Political Science. ; Economic Sociology. ; Education Policy. ; Innovation and Technology Management.
    Description / Table of Contents: Demography -- Incentives -- Urban Design -- Education -- Collaborative Governance.
    Abstract: This book attempts to advance critical knowledge and practices for fostering a variety of entrepreneurship at a city level. The book aims to connect scholarship and policy practice in two disciplines: Urban Studies and Entrepreneurship. The book has included contributions from developed, emerging, and developing countries. The chapters are clubbed under five main sections; I. Startups and Entrepreneurial Opportunities, II. Knowledge Spillover, III. Social and Bureaucratic Entrepreneurialism, IV. Demography and Informal Entrepreneurs V. Perspectives from Emerging and Developing Economies. In this regard, the book explores a number of questions, such as: what are the important varieties of entrepreneurship, how can they be observed and measured, and how does each variety emerge and operate under various conditions of infrastructure and opportunity? Which type(s) of entrepreneurship should a city prefer? What can cities do to stimulate desirable forms of entrepreneurship or is it more of a spontaneous phenomenon? Why do policies that enhance entrepreneurship in some contexts seem instead to promote crony capitalism and rent-seeking in other contexts? Should cities focus on growing their own entrepreneurs and entrepreneurial enterprises or on luring them from other cities and countries? How can a collective action in a city promote (or hinder) entrepreneurship? The contributions in the present volume address head-on these questions at the intersection of urban studies, economic theory, and the practicalities of economic development and urban governance, in a genuinely global range of places and applications.
    Type of Medium: Online Resource
    Pages: XII, 288 p. 27 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030151645
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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    Keywords: Sociology, Urban. ; Demography. ; Population. ; Emigration and immigration. ; Regional economics. ; Spatial economics. ; Architecture. ; Urban Sociology. ; Population and Demography. ; Human Migration. ; Regional and Spatial Economics. ; Cities, Countries, Regions.
    Description / Table of Contents: Introduction -- Functional Urban Areas - Theoretical Background -- Population Growth in Functional Urban Areas -- Regional Variation of Age Composition of Functional Urban Areas -- Ageing Processes in Functional Urban Areas -- Changes in Fertility and Mortality in Functional Urban Areas -- Changes in Migrations in Functional Urban Areas -- Spatial Typology of Functional Urban Areas (Based on Demographic Measurements) -- Summary.
    Abstract: This book explores demographic changes in Functional Urban Areas (FUAs) in Poland since 1990. Functional Urban Areas, introduced by ESPON, refer to functional territorial units that can be defined as travel-to-work-area, representing strong integration between urban cores and their immediate hinterland. The functional urban area consists of a city plus its commuting zone. It fills a significant gap in the academic literature by providing a deep and thorough analysis of the process of population change in Polish FUAs over the past 30 years. In particular, this empirical research work addresses population growth and decline; the main components of population growth including fertility, mortality and migration; age composition; and the pace of population ageing. The book argues that the transformations of urban structures are triggered by second demographic transition (SDT) and suburbanization processes. Based on data from the Central Statistical Office, this comparative study on FUAs in Poland, which employs a division into core and commuting zones, reveals essential similarities and differences in population development, making it possible to construct a demographic typology of FUAs and investigate their spatial arrangements. A unique and innovative book, it will appeal to geographers, demographers, urbanists, city planners and policymakers, as well as students, academic researchers and others involved in urban studies.
    Type of Medium: Online Resource
    Pages: VIII, 196 p. 97 illus., 95 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030315276
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Demography. ; Population. ; Geography. ; Religion and sociology. ; Political sociology. ; Urban Sociology. ; Population and Demography. ; Regional Geography. ; Sociology of Religion. ; Political Sociology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. The Haredi Jews in the UK -- Chapter 3. Measurement of the Jewish population in the UK -- Chapter 4. The Litvish world -- Chapter 5. The Hasidic world -- Chapter 6. Summary and conclusion.
    Abstract: This book focuses on the strict orthodox Jewish (Haredi) community, which comprises many sects whose communal identity plays a central role in everyday life and spatial organization. The research reveals and analyses powerful mechanisms of residential segregation acting at the apartment-, building- and near-neighbourhood levels. Identifying the main engines of spontaneous and organised neighbourhood change and evaluating the difficulties of liberalism dealing with non-autonomous individuals in the housing market sheds light on similar processes occurring in other city centres with diverse population groups. Highlighting the impact of various organisational levels on the spatial structure of the urban enclave, the book focuses on the internal dynamics of ethno-religious enclaves that emerge from three levels of action: (1) individuals' relationships with their own and other groups; (2) the community leadership's powers within the group and in respect of other groups; and (3) government directives and tools (e.g planning). The study examines how different levels of communal organisation are reflected in the residential patterns of four British communities: the Litvish communities of Golders Green and Gateshead, and the Hassidic communities of Stamford Hill and Canvey Island.
    Type of Medium: Online Resource
    Pages: XIII, 154 p. 32 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030258580
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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    Keywords: Sociology, Urban. ; Cities and towns History. ; Geography. ; Ethnology. ; Culture. ; Collective memory. ; Urban Sociology. ; Urban History. ; Regional Geography. ; Regional Cultural Studies. ; Memory Studies.
    Description / Table of Contents: Introduction -- Spatial Symbolism and Politics -- The Politicization of Berlin’s Urban Landscape, 1945 – 1989 -- Identity, Politics, and the Creation of Consensus -- The Cultural Landscape of the Berliner Republic: Undoing the Socialist Past -- Putting It All Together: Spatial Symbolism, Cultural Memory, Nation-Building, and Berlin’s Urban Development after 1989 -- Conclusion: Current Outlook, Recent Developments and Wider Relevance.
    Abstract: This book comprehensively examines post-1989 changes to the symbolic landscape of Berlin – specifically, street names, architecture, urban planning and monuments – and links these changes to concepts of contested cultural memory and national identity in Berlin and Germany in the post-Wall period. The core of the book is made up of an analysis of built space changes in the eastern half of the city before and after the Berlin Wall, flanked by an introduction to the theoretical underpinnings of the topic and a wider interpretation of the events in Berlin in relation to other geographic and historical contexts. It furthermore offers an explanatory model for the phenomenon of the "symbolic foreigner" whereby former citizens of the GDR feel disenfranchised and excluded from today's German society. This book is a valuable resource for researchers, students, and also appeals to a wider, non-academic audience with an interest in both cultural memory and Berlin.
    Type of Medium: Online Resource
    Pages: XXIII, 197 p. 58 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030297183
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Cities and towns History. ; Geography. ; Urban Sociology. ; Urban History. ; Regional Geography.
    Description / Table of Contents: Chapter 1. The urban, political and socioeconomic rise and fall of Belgrade through its history -- Chapter 2. Milena Vukmirovic -- Chapter 3. The rise and fall of New Belgrade with current developments in retrospect -- Chapter 4. Belgrade’s Waterfront revitalization -- Chapter 5. Reimaging Belgrade: the case of Savamala district -- Chapter 6. Public Art in Belgrade -- Chapter 7. Pedestrian-friendly Belgrade -- Chapter 8. Belgrade’s development visions and aims.
    Abstract: This book highlights Belgrade, reviewing its recent and historical developments and emphasizing its major ongoing planning projects. The book is divided into eight chapters. The first, entitled The urban, political and socioeconomic rise and fall of Belgrade through its history, introduces the reader to the city, and is followed by a chapter on Belgrade’s urban plans through history. The book continues with a chapter on one of the major urban projects in the former Yugoslavia, the construction of New Belgrade, its development and results, entitled New Belgrade: from no man’s land to modern city. In turn, the following three chapters explore three dominant contemporary topics: Belgrade’s riverfront redevelopment; Reimaging Belgrade: the case of Savamala; and Sustainable Belgrade. Expansion of the pedestrian zone in the city center. The book draws to a close with a chapter on Future predictions: South-Eastern European metropolis of the 21st century. This chapter in particular discusses large city projects and includes predictions about the city’s future.
    Type of Medium: Online Resource
    Pages: XII, 308 p. 213 illus., 203 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030350703
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Geography. ; Economic geography. ; Political planning. ; Urban Sociology. ; Geography. ; Economic Geography. ; Public Policy.
    Description / Table of Contents: Introduction -- Chapter 1. The Urban, Spas And Maritime Vilegiatura -- Chapter 2. The Metropolises Grow Towards The Sea, Northeast Of Brazil -- Chapter 3. Coastal Metropolitization And Tourist Real Estate -- Chapter 4. The Social And Urbanistic Effects Of Tourism Developments In Fortaleza, Brazil -- Conclusion.
    Abstract: This book intends to present the development of socio-spatial practices in the metropolitan coast of the Northeast of Brazil, highlighting the main urban, spa and tourist agglomerations: Salvador-BA, Recife-PE, Fortaleza-CE, and Natal-RN. The objective is to study the processes of urbanization associated with maritime leisure. In the first chapter, the reader will find a historical and conceptual presentation highlighting the relevance of leisure practices, their forms-flows and their role in the formation of maritime resorts. The second chapter analyses the context of the northeastern region of Brazil and demonstrates the process of modernization and formation of the seaside function within the cities, and later, in the maritime metropolises of the region. The relationship between urbanization and touristic real estate ventures is the central theme of the third chapter, which proposes a specific methodology for studies of this nature. The final chapter presents the seaside resorts in the metropolitan area of Fortaleza, a case study similar to others in the Northeast, examining the urbanistic effects and the key ideas of the planners.
    Type of Medium: Online Resource
    Pages: IX, 74 p. 19 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030465933
    Series Statement: SpringerBriefs in Latin American Studies,
    DDC: 307.76
    Language: English
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    Keywords: Sociology, Urban. ; Sustainability. ; Political planning. ; Urban Sociology. ; Sustainability. ; Public Policy.
    Description / Table of Contents: (Introduction) Making Sense of the Urban Agendas: Studies in the Production and Use of the Urban in Agenda Discourses -- Part I: The Urban Agenda for the European Union: Spatiality, Knowledge, Powers -- Understanding the Emergence of the Spanish Urban Agenda: Towards a New Multi-level Policy Scenario? -- Urban Policies in Portugal -- Gender Impact in the Agenda 2030 -- Part II: Scottish City Regional Deals: A New Type of Multi-level Partnership? -- The Politics of Making Regions - Competitiveness and the Re-presentation of Territoriality in Europe. The Case of the International Øresund Region -- Metropolitan Areas in Italy, Between National Agenda and Local Agendas -- Part III: The Urban Question in German Policy Making -- Metropolitan Development and Governance: the Cases of England and France -- Metropolitanizing a Nordic state? City-regionalist Imaginary and State Territorial Restructuring in Finland -- Part IV: Urban Agenda at the Regional Scale: the Case of Andalusia -- The Implementation of Madrid 2030 Agenda -- Urban Agenda and Metropolitan Governance: the Case of Milan -- Conclusion. Advancing Urban Agenda Research.
    Abstract: This book highlights the discontinuities and the ongoing development of the urban question in policy-making in the context of the controversial current issues of global reversal and regional revival. It critically examines contemporary public policies and practices at the urban, regional and national scales in order to offer a timely contribution to the debate on the significance of the urban dimension and interpretation in terms of the theory, policy and practice of social-spatial research in the twenty-first century. Focusing on Europe, it explores the current urban policy agendas at different scales - and the mobility of those agendas -, their implications, contradictions and controversies. It brings together original contributions from multiple disciplines but with an urban perspective, including empirical case studies and critical discussions of the following topics: the UN 2030 Agenda for Sustainable Development, the global “New Urban Agenda” as part of the Habitat III process; the Urban Agenda for the European Union; national spatial policies related to urban agendas; urban agendas at regional/urban levels; city regionalism discourse and state rescaling; new formal regional and metropolitan governments as a solution (or problem); the role of new actors in regional urbanization dynamics; multi-level governance processes in developing an urban agenda; informal assemblages at the metropolitan scale aiming at constructing the urban concept and dimension. Given its scope, the book is of interest to urban, regional and EU policy-makers, scholars and students working in the fields of urban geography, urban studies, EU urban and regional policies, and planning.
    Type of Medium: Online Resource
    Pages: XV, 316 p. 18 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030290733
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 64
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Engineering design. ; Buildings Design and construction. ; Medical informatics. ; Computer networks . ; Urban Sociology. ; Engineering Design. ; Building Construction and Design. ; Health Informatics. ; Computer Communication Networks.
    Description / Table of Contents: Part 1: PERSPECTIVES ON THE CITY. Chapter1.Smart Equity (Somwrita Sarkar) -- Chapter2. The Convenient City(Rob Roggema) -- Chapter3. Conceptualization of Smart City: A Methodological Framework for Smart Infrastructure, Smart Solutions and Smart Governance (Aurobindo Ogra) -- Part 2:SMART URBAN INFRASTRUCTURE. Chapter4. Development challenges for Big Data Command and Control Centres for Smart Cities in India (Sarbeswar Praharaj) -- Chapter5. Understanding consumer demand for new transport technologies and services, and implications for the future of mobility (Akshay Vij) -- Chapter6. Smart Interactive Cities: The Use of Computational Tools and Technologies [CTTs] as a Systemic Approach to Reduce Water and Energy Consumption in Urban Areas (Al Saeed Mahmoud and Fadli Fodil) -- Part 3: URBAN HEALTH AND WELLBEING. chapter7. Centenarian Transhumanism Aging in Place (Jennifer Loy) -- Chapter8. Grey smart societies: Supporting the social inclusion of older adults by smart spatial design (Nienke Moor and Masi Mohammadi) -- Chapter9. Real-time interactive multimodal systems for physiological and emotional wellbeing(Nimish Biloria and Dimitra Dritsa) -- Part 4: URBAN LIVING LABS -- Chapter10. Design Labs for Data Driven Multivalence(Mathias Funk) -- Chapter11. The role of living labs in developing smart cities in Indonesia(Hendra Sandhi Firmansyah) -- Part 5: DISRUPTIVE TECHNOLOGIES -- Chapter12. Algae Building: Is This the New Smart Sustainable Technology?( Sara J Wilkinson, Peter J Ralph and Nimish Biloria) -- Chapter13. The qualitative image: urban analytics, hybridity and digital representation(Linda Mathews) -- Part 6: SOCIO-SPATIAL ECOSYSTEMS -- Chapter14. Multimodal Accommodations for the Nomadic International citizen [MANIC}(Kas Oosterhuis) -- Chapter15. Understanding the relationship between smart cities and entrepreneurial ecosystems: the case of Sydney(Cetindamar, D., Lammers, T. and Sick, N.) -- Chapter16. Urban Wellbeing in the Contemporary City(Nimish Biloria, Prasuna Reddy, Yuti Ariani and Dhrumil Mehta) -- Part7: CONCLUSIONS.
    Abstract: This book sets the stage for understanding how the exponential escalation of digital ubiquity in the contemporary environment is being absorbed, modulated, processed and actively used for enhancing the performance of our built environment. S.M.A.R.T., in this context, is thus used as an acronym for Systems & Materials in Architectural Research and Technology, with a specific focus on interrogating the intricate relationship between information systems and associative material, cultural and socioeconomic formations within the built environment. This interrogation is deeply rooted in exploring inter-disciplinary research and design strategies involving nonlinear processes for developing meta-design systems, evidence based design solutions and methodological frameworks, some of which, are presented in this issue. Urban health and wellbeing, urban mobility and infrastructure, smart manufacturing, Interaction Design, Urban Design & Planning as well as Data Science, as prominent symbiotic domains constituting the Built Environment are represented in this first book in the S.M.A.R.T. series. The spectrum of chapters included in this volume helps in understanding the multivalence of data from a socio-technical perspective and provides insight into the methodological nuances involved in capturing, analysing and improving urban life via data driven technologies. .
    Type of Medium: Online Resource
    Pages: XIV, 338 p. 83 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030121808
    Series Statement: S.M.A.R.T. Environments,
    DDC: 307.76
    Language: English
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    Keywords: Sociology, Urban. ; Sustainable architecture. ; Urban Sociology. ; Sustainable Architecture/Green Buildings.
    Description / Table of Contents: Sustainable Urbanism: Advancing Compact Cities and Eco-cities through Data-Driven Smart Solutions and Approaches -- The Compact City Paradigm and its Centrality in Sustainable Urbanism: Ideals, Paradoxes, Strategies, and Data–driven Solutions -- Practical Advances in Compact City Planning and Development: The Cases of Gothenburg and Helsingborg, Sweden -- The Eco–City Paradigm and its Centrality in Sustainable Urbanism: Ideals, Models, Strategies, Limitations, and Data–Driven Smart Approaches -- Practical Advances in Eco–City Planning and Development: The Leading Examples and Cases of Stockholm and Malmö, Sweden -- The Data–Driven Smart City Paradigm and its Usefulness to Sustainable Urbanism: Technologies, Systems, and Sciences for Urban Intelligence Functioning -- Data–Driven Sustainable Urbanism and Data–Intensive Urban Sustainability Science: Novel Approaches to Urban Complexity -- The IoT and Big Data Analytics for Sustainable Cities: Enabling Technologies, Infrastructures, and Applications.
    Abstract: This book explores the recent advances in the leading paradigms of urbanism, namely compact cities, eco-cities, and data–driven smart cities, and the evolving approach to their amalgamation under the umbrella term of smart sustainable cities. It addresses these advances by investigating how and to what extent the strategies of compact cities and eco-cities and their merger have been enhanced and strengthened through new planning and development practices, and are being supported and leveraged by the applied solutions pertaining to data-driven smart cities. The ultimate goal is to advance sustainability and harness its synergistic effects on multiple scales. This entails developing and implementing more effective approaches to the balanced integration of the three dimensions of sustainability, as well as to producing combined effects of the strategies and solutions of the prevailing approaches to urbanism that are greater than the sum of their separate effects in terms of the tripartite value of sustainability. Sustainable urban development is today seen as one of the keys towards unlocking the quest for a sustainable world. And the big data revolution is set to erupt in cities throughout the world, heralding an era where instrumentation, datafication, and computation are increasingly pervading the very fabric of cities and the spaces we live in thanks to the IoT. Big data and the IoT technologies are seen as powerful forces that have tremendous potential for advancing urban sustainability. Indeed, they are instigating a massive change in the way sustainable cities can tackle the kind of special conundrums, wicked problems, and significant challenges they inherently embody as complex systems. They offer a multitudinous array of innovative solutions and sophisticated approaches informed by groundbreaking research and data–driven science. As such, they are becoming essential to the functioning of sustainable cities. Besides, yet knowing to what extent we are making progress towards sustainable cities is problematic, adding to the fragmented, conflicting picture that arises of change on the ground in the face of the escalating rate and scale of urbanization and in the light of emerging ICT and its novel applications. In a nutshell, new circumstances require new responses. This timely and multifaceted book is intended for a wide readership. As such, it will appeal to researchers, academics, urban scientists, urbanists, planners, designers, policy-makers, and futurists, as well as all readers interested in sustainable cities and their ongoing and future data-driven transformation.
    Type of Medium: Online Resource
    Pages: XVI, 290 p. 42 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030417468
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    DDC: 307.76
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Human geography. ; Regionalism. ; Urban Sociology. ; Human Geography. ; Regionalism.
    Description / Table of Contents: Co-production, Participatory Planning and Resilient Cities to Climate Change -- Participatory Transport Planning: the Experience of Eight Euro-pean Metropolitan Regions -- Participatory Planning in a Post-socialist Ur-ban Context: Experience From Five Cities in Central and Eastern Europe -- Governance and Management Systems in Mediterranean Marine and Coastal Biosphere Reserves -- Promises and Limits of Participatory Urban Greens Development: Experience from Maribor, Budapest, and Krakow.
    Abstract: This open access book provides in-depth insights into participatory research and planning by presenting practical examples of its use. In particular, it describes theoretical and methodological aspects of participatory research and planning, as well as the implementation of participatory processes in fields such as transport planning, cultural heritage management, environmental planning and post-earthquake recovery. Further, it compares participatory planning experiences from different territorial levels – from the macro-regional, e.g. Southeastern Europe, Mediterranean or European metropolitan regions, to national, regional and local levels. The book will help researchers, planners, public administration officials, decision-makers and the general public to understand the advantages, disadvantages and constraints of participatory planning and research. Using various examples, it will guide readers through the theory of participatory planning and research, its methods, and different perspectives on how to use it in practice.
    Type of Medium: Online Resource
    Pages: XI, 227 p. 26 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030280147
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Human geography. ; Urban Sociology. ; Human Geography.
    Description / Table of Contents: 1. Technocene,- 2. Sharing as cultural revolution -- 3. Sharing as cultural pre-existence -- 4. Co-housing -- 5. Co-housing cases -- 6. Hopes.
    Abstract: This book presents 50 case studies of contemporary co-housing projects spread all over the world to show how communities of shared living have become a global phenomenon that can serve as a tool to promote social and urban sustainability. By presenting evidence that shared housing experiences are capable of revitalizing sterile urban fabrics and promoting social sustainable practices, the volume situates co-housing experiences as microscale responses to the macroscale challenges posed by environmental degradation and the decline of communitarian ways of living. The volume also reviews the most famous typologies of shared living in different parts of the world across human history. By analyzing historical experiences in different regions of Africa, Americas, Asia, Europe and Oceania, the author shows that living together is part of a historical culture of sharing that is being rediscovered all over the world by people who activate public spaces, work in shared offices or live in contractual communities. The Co-Housing Phenomenon – Environmental Alliance in Times of Changes will be of interest to both professionals and scholars involved in urban design, urban planning and architecture, especially those in the field of sustainable urbanism. It will also be a valuable resource for public agents and civil society organizations dealing with housing, social, environmental and sustainability policies.
    Type of Medium: Online Resource
    Pages: XVI, 269 p. 195 illus., 188 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030370978
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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    Keywords: Sociology, Urban. ; Human geography. ; Cultural geography. ; Tourism. ; Management. ; Urban Sociology. ; Social and Cultural Geography. ; Tourism Management.
    Description / Table of Contents: Changing spaces in historical places -- Clarksdale, Mississippi: Downtown regeneration, cultural heritage, tourism and blues music -- Beer as cultural lubricant: Brewing Tsingtao, regenerating Qingdao -- Sporting heritage and touristic transformation: Pacaembu stadium and the football museum in São Paulo, Brazil -- Old town Tallinn: Medieval built heritage amid transformation.
    Abstract: Urban regeneration is often regarded as the process of renewal or redevelopment of spaces and places. There is a need to look at tourism and urban regeneration with a particular focus on cultural heritage. Cultural heritage consists of tangible heritage (such as historic buildings) and intangible heritage (such as events). The wider need and impact for such work is that places plan for change to keep up with the shifts in demand in the global economy in order for places to maintain a competitive advantage. Moreover, places need to keep up with the pace of global change or they risk stagnation and decline as increased competition is resulting in increased opportunities and choice for consumers. Each chapter in this book explores a specific form of cultural heritage that is driving change in urban spaces. Intended for a wide readership, the book will appeal to students of urban studies, human geography, heritage studies and international tourism management, as well as experts conducting research in and across these areas.
    Type of Medium: Online Resource
    Pages: XI, 213 p. 31 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030419059
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Sustainability. ; Religion. ; Urban Sociology. ; Sustainability. ; Religion.
    Description / Table of Contents: Religion and Urban Planning -- Religious Matrimony and Urban Sprawl -- The dichotomy between the living and the dead -- Theology and Governance -- On Faith and Big Data.-Conclusion. .
    Abstract: Even though theology does provide interesting and important contributions to ethics that laid the foundation of our modern societies, this book looks at exploring how theology has impacted on urban morphology and has led to questionable unsustainable practices which impacts on both climate and societal living standards. This is seen as being accelerated with the impacts of climate change coupled with increasing urbanisation rates that stresses on contemporary notions and foundations, as initially sparked by religion. Through an argumentative style, the author sets forth to explore the ethics of religious dogmas in a rapidly urbanising world that is stressed by increasing consumption from a booming demographic.
    Type of Medium: Online Resource
    Pages: XI, 83 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030296735
    Series Statement: SpringerBriefs in Geography,
    DDC: 307.76
    Language: English
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    Keywords: Sociology, Urban. ; Political science. ; Public administration. ; Urban Sociology. ; Governance and Government. ; Public Administration.
    Description / Table of Contents: Conceptualising Metropolitan Regions: How Institutions, Policies, Spatial Imaginaries and Planning are Influencing Metropolitan Development -- Part I: Institutions and Contemporary Institutional Shifts -- Metropolitan Revolution or Metropolitan Evolution? The (Dis)continuities in Metropolitan Institutional Reforms -- The Multiple Agencies of Metropolitan Institutions: Is There Convergence? -- What is at Stake for Metropolitan Regions and Their Governance Institutions? -- Part II: Policies and Ideas -- Learning from Elsewhere? A Critical Account on the Mobilisation of Metropolitan Policies -- From Here to There: Mapping the Metropolitan Politics of Policy Mobilities.
    Abstract: The aim of this book is to investigate contemporary processes of metropolitan change and approaches to planning and governing metropolitan regions. To do so, it focuses on four central tenets of metropolitan change in terms of planning and governance: institutional approaches, policy mobilities, spatial imaginaries, and planning styles. The book’s main contribution lies in providing readers with a new conceptual and analytical framework for researching contemporary dynamics in metropolitan regions. It will chiefly benefit researchers and students in planning, urban studies, policy and governance studies, especially those interested in metropolitan regions. The relentless pace of urban change in globalization poses fundamental questions about how to best plan and govern 21st-century metropolitan regions. The problem for metropolitan regions—especially for those with policy and decision-making responsibilities—is a growing recognition that these spaces are typically reliant on inadequate urban-economic infrastructure and fragmented planning and governance arrangements. Moreover, as the demand for more ‘appropriate’—i.e., more flexible, networked and smart—forms of planning and governance increases, new expressions of territorial cooperation and conflict are emerging around issues and agendas of (de-)growth, infrastructure expansion, and the collective provision of services.
    Type of Medium: Online Resource
    Pages: XV, 270 p. 16 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030256326
    DDC: 307.76
    Language: English
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    Keywords: Cancer. ; Medical microbiology. ; Cytology. ; Pediatrics. ; Cancer Biology. ; Medical Microbiology. ; Cell Biology. ; Pediatrics.
    Description / Table of Contents: Adjuvant and Neoadjuvant Chemotherapy for Osteosarcoma: A Historical Perspective -- Part 1: Surgical Considerations and Outcomes -- Limb Salvage and Reconstruction Options in Osteosarcoma -- Advances in the functional assessment of patients with sarcoma -- Part II: Novel Therapeutic Approaches Based on Biology -- Radiopharmaceuticals for Treatment of Osteosarcoma -- HER-2 Targeted Therapy in Osteosarcoma -- Aerosolized Chemotherapy for Osteosarcoma -- The Histone Deacetylase inhibitor Entinostat/Syndax 275 in Osteosarcoma -- Relapsed Osteosarcoma Trial Concepts to Match the Complexity of the Disease -- Using liquid biopsy in the treatment of patient with osteosarcoma -- Part III: Novel Immunotherapeutic Approaches -- Genetically modified T-cell therapy for osteosarcoma: into the roaring 2020’s -- Muramyl Tripeptide-Phosphatidyl Ethanolamine Encapsulated in Liposomes (L-MTP-PE) in the Treatment of Osteosarcoma -- Natural Killer Cell Immunotherapy for Osteosarcoma -- Nanocapsule delivery of IL-12 -- Discovery of cell surface vimentin (CSV) as a sarcoma target and development of CSV-targeted IL-12 immune therapy -- Part IV: Survivorship and Late Effects -- Editorial Comments on late effects -- Anthracycline-Induced Cardiotoxicity: Causes, mechanisms & prevention -- Exercise and Physical Activity in Patients with Osteosarcoma and Survivors -- Index.
    Abstract: This thoroughly revised second edition complied in 2 books is an up-to-date overview of the current clinical advances in sarcoma and osteosarcoma. The new edition features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, these essential volumes also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists focused in sarcoma.
    Type of Medium: Online Resource
    Pages: XIII, 212 p. 24 illus., 17 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030430320
    Series Statement: Advances in Experimental Medicine and Biology, 1257
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Cancer Biology.
    Description / Table of Contents: Chapter 1. Chemoprevention of Cancer - Past,Present, and Future -- Chapter 2. Resveratrol for Cancer Prevention: Current Gaps and Opportunities -- Chapter 3. Pterostilbene as a Potent Chemopreventive Agent in Cancer -- Chapter 4. Pharmacokinetics and Bioavailability Enhancement of Natural Products -- Chapter 5. Vitamin D Compounds and Cancer Stem Cells in Cancer Prevention -- Chapter 6. Anti-cancer Effects of Silibinin – The Current Status in Cancer Chemoprevention -- Chapter 7. Adjuvant Value of Turmeric Extract (Containing Curcumin) in Colorectal Cancer Management -- Chapter 8. Cancer Prevention by Tea Polyphenols -- Chapter 9. The Chemopreventive Power of Isothiocyanates -- Chapter 10. Xanthohumol and Structurally Related Prenylflavonoids for Cancer Chemoprevention and Control -- Chapter 11. Anthocyanins and Cancer Prevention -- Chapter 12. Grape ChemopreventiveAgents AgainstAngiogenesis and Metastasis -- Chapter 13. Punicagranatum L. Constituents for Cancer Prevention, Chemosensitisation and Therapeutic Treatment -- Chapter 14. Cancer ChemopreventivePotential of Epidermal Growth Factor Receptor Inhibitors from Natural Products -- Chapter 15. Anti-cancer Dynamics of Natural Phytochemical Inhibitors of Cyclin-dependent Kinases -- Chapter 16. Pro-apoptotic Properties of Chemopreventive Agents -- Chapter 17. The Use of Anti-inflammatory Agents for Cancer Chemoprevention -- Chapter 18. Combination Chemoprevention by Targeting the Epigenome -- Chapter 19. Perspective – a positive cocktail effect of the bioactive components in the diet.
    Abstract: This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research. .
    Type of Medium: Online Resource
    Pages: XX, 629 p. 59 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030398552
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Hematopoietic system. ; Cytology. ; Cancer Microenvironment. ; Haematopoietic System. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: Eosinophils in the tumor microenvironment -- Dendritic cells in the tumor microenvironment -- Resident memory T cells in the tumor microenvironment -- NK cells in the tumor microenvironment -- γδ T cells in tumor microenvironment -- Regulatory T Cells in the Tumor Microenvironment -- The Hematopoietic Microenvironment in Myeloproliferative Neoplasms: The Interplay Between Nature (Stem Cells) and Nurture (the Niche) -- Langerhans cells in the tumor microenvironment -- Mast cells in the tumor microenvironment -- B cells in the gastrointestinal tumor microenvironment with a focus on pancreatic cancer: opportunities for precision medicine? -- Microglia in the Brain Tumor Microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include eosinophils, NK cells, γδ T cells, regulatory T Cells, Langerhans cells, hematopoietic stem cells, Mast cells, B cells and Microglia, and more. Taken alongside its companion volumes, Tumor Microenvironment: Hematopoietic Cells – Part B updates us on what we know about various aspects of the tumor microenvironment as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIV, 215 p. 26 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030492700
    Series Statement: Advances in Experimental Medicine and Biology, 1273
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Oncology. ; Cancer Biology. ; Oncology.
    Description / Table of Contents: Role of specific phytochemicals against gastrointestinal malignancies -- Role of phytochemicals on growth and metastasis of GI cancer -- Cancer Stem Cells as Therapeutic Targets for Gastrointestinal cancers -- Phytochemicals plus checkpoint inhibitors in GI cancers -- Crucial role of curcumin on gut microbiota associated with GI cancers -- Cellular and Molecular mechanisms of garlic compounds in common GI cancers -- Combination of Phytochemicals with Nanotechnology for Targeting GI Cancer Therapy -- Emerging Roles of Phytochemicals in the Pathobiology and Management of Esophageal Cancer -- Gastric Cancer: Role of Phytochemicals and Tyrosine Kinase Inhibitors -- Therapeutic Efects Of Curcumin Against Colorectal Cancer -- Molecular Pathways Involved in the Pathogenesis of Pancreatic Cancer: Role of Phytochemicals in Targeting the Clinical Outcomes -- Role of Dietary Supplementation of Natural products in the Prevention and Treatment of Liver Diseases -- Emerging Roles of Phytochemicals in Hepatocellular Carcinoma -- Phytochemicals: Current Understandings of the Modern Therapeutic Approaches for Hepatocellular Carcinoma -- Index.
    Abstract: Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
    Type of Medium: Online Resource
    Pages: XI, 340 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030484057
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: Targeting Glioblastoma Tumor Microenvironment -- Recent Advances in Head and Neck Tumor Microenvironment Based Therapy -- Meningioma Tumor Microenvironment -- The microenvironment of tongue cancer -- Laryngeal Tumor Microenvironment -- Esophageal tumor microenvironment -- The pituitary tumours and their tumour specific microenvironment -- Pineal gland tumor microenvironment -- Carotid Body Tumor Microenvironment -- The mammary tumor microenvironment -- Integrated Targeting of Lethal Prostate Tumor Phenotype -- The Many Microenvironments of Ovarian Cancer -- Endometrial tumour microenvironment -- Liver Tumor Microenvironment -- Pancreatic Tumor Microenvironment -- Sweat gland tumor microenvironment -- The tumor microenvironment of bladder cancer -- Tumor microenvironment in penile cancer -- Seminal vesicle tumor microenvironment -- Sarcoma tumor microenvironment -- Tumor Environment of Retinoblastoma, Intraocular Cancer -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment components in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in several organs, including brain, neck, tongue, larynges, esophagus, carotid body, breast, prostate, ovary, endometrium, liver, pancreas, bladder, penis, seminal vesicle, retina, and pituitary, pineal and sweat glands, and more. Taken alongside its companion volumes, Tumor Microenvironments in Organs: From the Brain to the Skin – Part B updates us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XVII, 376 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030590383
    Series Statement: Advances in Experimental Medicine and Biology, 1296
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Medical genetics. ; Immunology. ; Human physiology. ; Cytology. ; Cancer Biology. ; Biomedical Research. ; Medical Genetics. ; Immunology. ; Human Physiology. ; Cell Biology.
    Description / Table of Contents: Preface -- Tumor microenvironment a job of several holders -- Tumor microenvironment- a selective pressure boosting cancer -- Lactate and lactate transporters as key players in the maintenance of the Warburg effect -- Section 1. Adaptive metabolic features are sustained by tumor microenvironment -- Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis -- Gut microbiota and cancer of the host: colliding interests -- Metabolic plasticity of tumor cells: how they do adapt to food deprivation -- Multifaceted oncogenic role of adipocytes in the tumour microenvironment -- Endothelial cells (ECs) metabolism a valuable piece to disentangle cancer biology -- Monocytes and macrophages in cancer: unsuspected roles -- Section 2. Microenvironment and metabolic signalling- the way cancer cells know how to survive.-: Wnt signaling: paths for cancer progression -- Microenvironment driven metabolic adaptation in melanoma -- Metabolic reprogramming and signaling to chromatin modifications in tumorigenesis -- Inflammatory microenvironment modulation of alternative splicing in cancer: a way to adapt -- The bone marrow niche - the tumor microenvironment that ensures leukemia progression -- Section 3. Metabolic fitness and therapy response in cancer -- Exploiting cancer cells metabolic adaptability to enhance therapy response in cancer -- The metabolic remodelling in lung cancer and its putative consequence in therapy response -- Hydrogen sulfide metabolism and signaling in the tumor microenvironment -- Using metabolic adaptation to design new drugs -- Metabolomics- a new way of screening cancer -- NMR as a tool for metabolomics -- Section 5. Animal models- addressing cancer microenvironment -- Animal models to study cancer and its microenvironment -- Modulating the metabolic phenotype of cancer microenvironment -- Modeling of Solid-tumor Microenvironment in Zebrafish (Danio Rerio) Larvae -- Section 6. In vitro and ex vivo cancer models -- In vitro and ex vivo models- the tumor microenvironment in a flask -- Index.
    Abstract: This book will allow readers to discover the crucial role of tumor microenvironment (TME) in the selection of cancer cells that are more prone to carry on cancer initiation and progression. The metabolic remodeling, as the basis of life overall, allows the adaptive establishment of a tumor in a certain TME, which in turn presents a variety of selective pressures. Coupled with the late diagnosis, the poor therapy response are the main hurdles limiting oncological disease control and eventual cure. Thus the metabolic plasticity of cancer cells often underlies chemoresistance. This edited work presents an exhaustive description and comprehensive view of cancer metabolism as a weapon used by cancer cells to adapt to TME. TME and the organ microenvironment is analyzed as a whole, considering cancer cells, stromal cells and microbiota. This complex circuit is observed as the support for disease development and therapy evasion but also as a valuable kernel, presenting new players to be targeted in a more precise cancer therapy. The various threads of cancer biology related to TME and metabolic adaptation will be addressed including: 1) key players in the metabolic network; 2) the way adaptive metabolic features are sustained by TME; 3) TME and metabolic signaling, accounting for cancer cells survival; 4) metabolic fitness driven limitations in therapy response, and 5) the way TME and cancer metabolism can be helpful in the design of new drugs. In addition, the usefulness, technical strengths and weaknesses of analytical techniques useful in cancer metabolomics will be presented in an integrative way. Moreover, the use of innovative and traditional in vitro and in vivo cancer models, as powerful tools to address the influence of TME in cancer progression and metabolic reprogramming will be also presented. This work was written by experts and dedicated to researchers with interests in cancer biology, TME, cancer metabolism and therapy. It will interest the Advances in Experimental Medicine and Biology readership, including basic researchers, analytic researchers, bio-engineers and clinicians.
    Type of Medium: Online Resource
    Pages: VII, 443 p. 63 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030340254
    Series Statement: Advances in Experimental Medicine and Biology, 1219
    DDC: 571.978
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Biology.
    Description / Table of Contents: Chapter 1: Introduction to Kinases, Cellular Signaling, and Kinase Inhibitors -- Chapter 2: Overview of Current Type I/II Kinase Inhibitors -- Chapter 3: Avoiding or Co-opting ATP Inhibition: Type III, IV, V, and VI Kinase Inhibitors -- Chapter 4: Structural Features Regulating Kinase Interactions with Regulatory and Substrate Proteins -- Chapter 5: Developing Kinase Inhibitors using Computer-Aided Drug Design Approaches -- Chapter 6: A Toolbox of Structural Biology and Enzyme Kinetics Reveals the Case for ERK Docking Site Inhibition -- Chapter 7: Novel Stabilized Peptide Inhibitors of Protein Kinases -- Chapter 8: Novel peptide-based inhibitors of protein kinases -- Index.
    Abstract: Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease. .
    Type of Medium: Online Resource
    Pages: XII, 217 p. 59 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030482831
    DDC: 571.978
    Language: English
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  • 78
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Notch signalling and embryology: an introduction -- Notch signaling and embryonic development: an ancient friend, revisited -- The Five Faces of Notch Signalling During Drosophila melanogaster Embryonic CNS Development -- Epigenetic regulation of Notch signaling during Drosophila development -- Regulation of proneural wave propagation through a combination of Notch-mediated lateral inhibition and EGF-mediated reaction diffusion -- A nucleolar protein, Nepro, is essential for the maintenance of early neural stem cells and preimplantation embryos -- The role of Notch signaling in leg development in Drosophila melanogaster -- Notch pathway and inherited diseases: challenge and promise -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books – Molecular Biology of Notch Signaling and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students. .
    Type of Medium: Online Resource
    Pages: XIII, 195 p. 16 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030344368
    Series Statement: Advances in Experimental Medicine and Biology, 1218
    DDC: 571.978
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Proteins. ; Cancer Biology. ; Cell Biology. ; Proteins.
    Description / Table of Contents: Introduction to purinergic signaling in the brain -- Adenosine signaling in glioma cells -- Cross-talk in nucleotide signaling in glioma c6 cells -- Calcium signaling in glioma cells – the role of nucleotide receptors -- Purinergic signaling in glioma progression -- Cytoskeleton and nucleotide signaling in glioma c6 cells -- Signaling determinants of glioma cell invasion -- Receptor tyrosine kinases: principles and functions in glioma invasion -- Recent advances in understanding mechanisms of tgf beta signaling and its role in glioma pathogenesis -- Stat signaling in glioma cells -- Cannabinoid signaling in glioma cells -- Effects of arginine and its deprivation on human glioblastoma physiology and signaling -- Histone modifying enzymes and chromatin modifiers in glioma pathobiology and therapy responses -- Role of infiltrating microglia/macrophages in glioma. .
    Abstract: Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumor, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. This book is a reference on cellular signaling processes regulating gliomas physiology and invasiveness. The work is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides and formation of complex signaling cascades induced by growth factors, cytokines and cannabinoids. The second edition of the book enriched in new chapters provides a framework explaining how signal transduction elements may modulate numerous genetic and epigenetic alterations, describes the role of local microenvironment in cellular growth, progression and invasion and, in the light of extensive new results, presents perspectives concerning potential targets for gliomas therapy.
    Type of Medium: Online Resource
    Pages: XI, 305 p. 48 illus., 36 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030306519
    Series Statement: Advances in Experimental Medicine and Biology, 1202
    DDC: 571.978
    Language: English
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  • 80
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Cultural property. ; Critical theory. ; Urban Sociology. ; Cultural Heritage. ; Critical Theory.
    Description / Table of Contents: Introduction -- Using Foucault’s Toolbox: Heterotopia as a New Tool for Assessing Built Heritage -- Heterotopia as Materialised Utopia. Utopias and their Architectural Embodiment. The ‘Heritage Utopia’ -- Heterotopia of Function vs. the Heterotopia of Form. The Heterotopic Principles, their Interpretation and the Built Heritage. The Heritage Perspective -- Heritage as Heterotopia and the Heterotopic Profile as an Analysis Tool.
    Abstract: This book approaches the field of built heritage and its practices by employing the concept of heterotopia, established by the French philosopher Michel Foucault. The fundamental understandings of heritage, its evolution and practices all reveal intrinsic heterotopic features (the mirror function, its utopic drive, and its enclave-like nature). The book draws on previous interpretations of heterotopia and argues for a reading of heritage as heterotopia, considering various heritage mechanisms – heritage selection, conservation and protection practices, and heritage as mnemonic device – in this regard. Reworking the six heterotopic principles, an analysis grid is designed and applied to various built heritage spaces (vernacular, religious architecture, urban 19th century ensembles). Guided through this theoretical itinerary, the reader will rediscover the heterotopic lens as a minor yet promising Foucauldian device that allows a better understanding of heritage and its everyday practices.
    Type of Medium: Online Resource
    Pages: X, 483 p. 6 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030182595
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 81
    Keywords: Sociology, Urban. ; Transportation engineering. ; Traffic engineering. ; Urban ecology (Biology). ; Urban Sociology. ; Transportation Technology and Traffic Engineering. ; Urban Ecology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Transit-Oriented Development (TOD) and its problems -- Chapter 3. Why GOD? The benefits of Greenspace-Oriented Development 1 -- Chapter 4. A manual for implementing Greenspace-Oriented Development -- Chapter 5. Conclusion.
    Abstract: Transit-Oriented Development (TOD) planning principles have informed Australian city planning for over two decades. As such, policy makers and planners often unquestioningly apply its principles. In contrast, this book critiques TOD and argues that while orientating development towards public transport hubs makes some sense, the application of TOD principles in Australia has proven a significant challenge. As a complementary strategy, the book stakes out the potential of Greenspace-Oriented Development (GOD) in which urban density is correlated with upgraded green spaces with reasonable access to public transport. Concentrating urban densification around green spaces offers many advantages to residents including ecosystem services such as physical and mental health benefits, the mitigation of extreme heat events, biodiversity and clean air and water. Moreover, the open space and leafy green qualities of GOD will ensure it resonates with the lifestyle aspirations of suburban residents who may otherwise resist urban densification. We believe in this way, that GOD could be an urban dream that befits the challenges of this 21st century.
    Type of Medium: Online Resource
    Pages: XV, 94 p. 51 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030296018
    Series Statement: SpringerBriefs in Geography,
    DDC: 307.76
    Language: English
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  • 82
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Financial risk management. ; Physical geography. ; Climatology. ; Urban Sociology. ; Risk Management. ; Physical Geography. ; Climate Sciences.
    Description / Table of Contents: Chapter 1. The promise of security -- Chapter 2. Responding to disasters -- Chapter 3. The Region of Umbria as case study -- Chapter 4. Planning for resilience -- Reference.
    Abstract: Given the increasing uncertainty due to catastrophic climate events, terrorist attacks, and economic crises, this book addresses planning for resilience by focusing on sharing knowledge among policy-makers, urban planners, emergency teams and citizens. Chapters look at the nature of contemporary risks, the widespread of resilience thinking and the gap between the theoretical conception and the practices. The book explores how resilience implies a change in planning practices, highlighting the need for flexibility in terms of procedures, and for dynamism in the knowledge systems and learning processes that are the main tools for interaction among different actors and scales. Given its breadth of coverage, the book offers a valuable resource for both academic readers (spatial planners, geographers, social scientists) and practitioners (policymakers, citizens’ associations).
    Type of Medium: Online Resource
    Pages: X, 88 p. 4 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030172626
    Series Statement: SpringerBriefs in Geography,
    DDC: 307.76
    Language: English
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  • 83
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Sustainability. ; Regionalism. ; Urban Sociology. ; Sustainability. ; Regionalism.
    Description / Table of Contents: Introduction -- Shifting urban dynamics: An overview -- From megacity to megacity region: Is an Asian paradigm emerging?- Asian MCR: Urban-Rural interface and multidimensionality of the spread region -- Scale and where the three prongs meet -- The national capital region, Delhi, India: An empirical exploration -- Concluding thoughts.
    Abstract: This book argues that close and disciplined scrutiny of the Asian megacity regions is of critical importance to understanding Asian urbanization. However, any approach to studying these regions must adopt a multi-dimensional and trans-urban perspective; otherwise, we Without such an approach, we cannot truly make meaningful decisions about growth management and sustainable development for such regions. Amidst the sweeping demographic and structural shifts produced by global urbanization, Asian urbanization has a fascinating and prominent role. Asian urbanization is heterogeneous, and more accurately constitutes “phenomena” than a “phenomenon.” However, despite this diversity, there are certain common features that we can identify. One of them is the Asian “megacity region”— the administrative and/or delineated territory of mixed urban-rural landscape surrounding a giant metropolis. The purpose of this book is to: Understand the main features of 21st century urbanization Note the limitations of current approaches (e.g. disparate scales, city-centric views, inadequate data sets) Articulate a pragmatically framed three-pronged approach (scale-based, trans-urban, multi-dimensional) Demonstrate the application of such an approach with a case study of one of the most important megacity regions in South Asia, the Delhi National Capital Region, underscoring the methodological requirements of such an approach Discuss the next steps for the field as a whole: questions to be raised and directions to be explored for further study. This timely, conceptual and empirical book will appeal to students of urbanization, architects involved in urban policy and planning, and researchers alike.
    Type of Medium: Online Resource
    Pages: XIX, 225 p. 28 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030426491
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 84
    Keywords: Sociology, Urban. ; Environment. ; Renewable energy sources. ; Refuse and refuse disposal. ; Quality of life. ; Urban Sociology. ; Environmental Sciences. ; Renewable Energy. ; Waste Management/Waste Technology. ; Quality of Life Research.
    Description / Table of Contents: 1. The Rocinha favela and past slum upgrading programmes in Rio de Janeiro / Brazil; shortcomings of past experiences and limitations of fragmented transformation actions -- 2. The Integrated Modification Methodology (how it works + past examples of its application to formal contexts + comparison with other methodologies/tools used for similar purposes) -- 3. Analysis of the existing situation (IMM Diagnostic phase) -- 4. Urban metabolism and identification of intervention areas (IMM Assumption phase) -- 5. Projects: energy -- 6. Projects: ecosystem -- services -- 7. Projects: waste -- 8. Projects: wastewater treatment -- 9. Projects: food -- 10. Projects: mobility -- 11. Analysis of system-wide improvements (IMM Retrofit phase) -- 12. Conclusions.
    Abstract: This book discusses the potential of a systemic and multidisciplinary design approach to improve urban quality, health, livability, and inclusiveness for people living in informal settlements. In most instances, attempts to address informal settlements lack an adequate assessment of their impact on the wider built environment and implementation of the UN’s Sustainable Development Goals. The Integrated Modification Methodology (IMM), introduced here, offers a systematic, multidisciplinary design tool encompassing several of the aspects that define the environmental performance of urban systems. The book also demonstrates the application of the methodology to an informal settlement, proving its potential to guide systemicurban transformations, also in urban areas lacking formal planning. The case study investigated is in the Rocinha favela in Rio de Janeiro, which ischaracterized by poor water quality, lack of drainage and sanitation systems, and very few green spaces. Based on a rigorous methodology, the process described here can also be applied in similar contexts around the world.
    Type of Medium: Online Resource
    Pages: XIV, 236 p. 121 illus., 110 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030443528
    Series Statement: Research for Development,
    DDC: 307.76
    Language: English
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  • 85
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Europe Politics and government. ; Comparative government. ; Political science. ; Knowledge, Sociology of. ; Urban Sociology. ; European Politics. ; Comparative Politics. ; Political Science. ; Sociology of Knowledge and Discourse.
    Description / Table of Contents: Preface -- List of Tables -- List of Figures -- Abbreviations and Acronyms -- Abstract -- Zusammenfassung -- 1) Introduction: The European Metropolis in the Making? -- 2) The European Dimension of Metropolitan Policies -- 3) Theorising Europeanisation as Policy Learning and Reframing -- 4) Understanding Metropolitan Policies from a Comparative-Interpretive Perspective -- 5) Europeanising Metropolitan Regions: The European Dimension of Metropolitan Policies in Lyon and Stuttgart -- 6) The European Dimension of French and German Metropolitan Policies -- 7) Metropolitan Policies of the European Union -- 8) Comparing the European Dimension of Metropolitan Policies from an Interpretive Perspective -- 9) Concluding Reflections on Europeanising Metropolitan Policies -- Appendices -- Appendix A) Examples of Interview Guidelines and Questionnaires -- Appendix B) List of Interview Partners -- Appendix C) Overview of Selected Documents from the European Union Context -- Appendix D) Example Coding Tree -- References.
    Abstract: This book questions how policies for the metropolis become Europeanised. The book analyses how spatial concepts and political ideas permeate the European multi-level system. Through an interpretive comparison of five contexts, the book provides an overview of the European orientation tracing two interdependent developments. First, the book examines references to ‘Europe’ in national and subnational policies. In French and German policies, metropolitan regions are increasingly framed as being central not only for inter-municipal coordination, but also as nodes within the European space. Moreover, Europeanised metropolitan regions such as Lyon and Stuttgart develop European strategies. The second development shows how metropolitan regions appear as actors and issues in the European policy arena, contributing to a tentative and implicit metropolitan dimension. This multi-scalar analysis is of interest for scholars and practitioners specialised in metropolitan regions, European urban and regional policies, geography and related areas.
    Type of Medium: Online Resource
    Pages: XXII, 348 p. 17 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030146146
    Series Statement: Springer Geography,
    DDC: 307.76
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Urban economics. ; Dynamics. ; Nonlinear theories. ; Urban Sociology. ; Urban Economics. ; Applied Dynamical Systems.
    Description / Table of Contents: Introduction -- Theories of complexity and urban systems -- Scaling laws: universal solutions for urban planning or contingent products of circumstances? -- Economy versus geography: theories of urbanization and cities development -- Urban theories and international comparisons -- Complex systems modeling for better understanding urbanization theories -- Conclusion.
    Abstract: This book provides a thorough discussion about fundamental questions regarding urban theories and modeling. It is a curated collection of contributions to a workshop held in Paris on October 12th and 13th 2017 at the Institute of Complex Systems by the team of ERC GeoDiverCity. There are several chapters conveying the answers given by single authors to problems of conceptualization and modeling and others in which scholars reply to their conception and question them. Even, the chapters transcribing keynote presentations were rewritten according to contributions from the respective discussions. The result is a complete “state of the art” of what is our knowledge about urban processes and their possible formalization.
    Type of Medium: Online Resource
    Pages: VIII, 330 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030366568
    Series Statement: Lecture Notes in Morphogenesis,
    DDC: 307.76
    Language: English
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  • 87
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Geographic information systems. ; Public health. ; Environmental geography. ; Computer simulation. ; Big data. ; Urban Sociology. ; Geographical Information System. ; Public Health. ; Integrated Geography. ; Computer Modelling. ; Big Data.
    Description / Table of Contents: Chapter 1. Introduction -- Part I. Urban Health Risk and Disease -- Chapter 2. Geospatial Approaches to Measuring Personal Heat Exposure and Related Health Effects in Urban Settings -- Chapter 3. Geographic variation in Cardiovascular disease mortality: A study of linking risk factors and built environment at a local health unit in Canada -- Chapter 4. Evaluating the effect of domain size of the Community Multiscale Air Quality (CMAQ) model on regional PM2.5 simulations -- Part II- Urban Health Service Access -- Chapter 5. Serving a Segregated Metropolitan Area: Disparities in Spatial Access to Primary Care Physicians in Baton Rouge, Louisiana -- Chapter 6. Considerations When Using Individual GPS Data in Food Environment Research: A Scoping Review of ‘Selective (Daily) Mobility Bias’ in GPS Exposure Studies and its Relevance to the Retail Food Environment -- Chapter 7. Dynamic Emergency Medical Service Dispatch: Role of Spatiotemporal Machine Learning -- Part III. Healthy Behavior and Urban Lifestyle -- Chapter 8. Incorporating Online Survey and Social Media Data into a GIS Analysis for Measuring Walkability -- Chapter 9. Leveraging social media to track urban park quality for improved citizen health -- Part IV. Health Policies and Urban Health Management -- Chapter 10. Spatio-temporal Analysis and Data Mining of the 2014-2016 Ebola Virus Disease Outbreak in West Africa -- Chapter 11. Extending Volunteered Geographic Information (VGI) with Geospatial Software as a Service: Participatory Asset Mapping Infrastructures for Urban Health -- Chapter 12. Improving Urban and Peri-Urban Health Outcomes Through Early Detection and Aid Planning.
    Abstract: This volume presents a timely collection of research papers on the progress, opportunities, and challenges related to the advancement of geospatial technologies for applications in urban health research and management. The chapter authors cover technologies ranging from traditional GIS and remote sensing technologies, to recently developed tracking/locational technologies and volunteered geographic information (VGI). In four main sections, the book uniquely contributes to the conversation of how geospatial technologies and other GIScience research may be enhanced by addressing the data and challenges presented by urban health issues. The book is intended for those with backgrounds in health and medical geography, social epidemiology, urban planning, health management, and lifestyle research. The book starts with an introduction by the editors, providing an overview of traditional and emerging geospatial technologies and how they each can significantly contribute to urban health studies. Section 1 covers urban health risk and disease, and analyses the spatial and temporal patterns of selected urban health issues. Section 2 addresses urban health service access, and demonstrates how traditional and new geospatial technologies apply to different segments of urban populations facing varied challenges. Section 3 focuses on incorporating geospatial technologies in promoting healthy behaviours and lifestyles in urban settings. Section 4 assesses how geospatial technologies may be incorporated into urban health policies and management practices. Adopting a forward-looking perspective, these papers examine the various health challenges in urban systems, and explore how new and emerging geospatial technologies will need to develop to address these problems. .
    Type of Medium: Online Resource
    Pages: XI, 259 p. 60 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030195731
    Series Statement: Global Perspectives on Health Geography,
    DDC: 307.76
    Language: English
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  • 88
    Keywords: Sociology, Urban. ; Cultural property. ; Natural disasters. ; Political sociology. ; Human geography. ; Cultural geography. ; Urban Sociology. ; Cultural Heritage. ; Natural Hazards. ; Political Sociology. ; Social and Cultural Geography.
    Description / Table of Contents: Introduction -- Part I: Urban Heritage and Cultural Identity -- Public Open Spaces in Bahrain: Connecting Migrants and Urban Heritage in a Transcultural City -- Paradise Extended; Re-examining the Cultural Anchors of the Historic Pleasure Avenues -- Landscape Architecture Significance in Restoration Historical Areas, Old “Muharak” City, Bahrain -- Part II: Governing Urban Heritage -- The Rise of the Facilitation Approach in Tackling Neighbourhood Decline in Tehran.
    Abstract: This book examines examples of contemporary situation of historic regions in the Middle East and its broader geographic context connected to the historic trade routes, offering cross-disciplinary and cross-sectoral perspectives. The region is home to ancient settlements and early human endeavors to form cities, and across the region historic urban historic features, such as ancient city centers, still exist alongside contemporary ones. Many of those historic regions are along the Silk Roads. However, the urban continuity that once existed over generations in the physical and social paradigm have been interrupted by rapid urbanization, globalization and urban economic pressures, in addition to conflicts and frequent destructive natural hazards. It is often the case that dealing with such pressing issues in a historic city is more complex than dealing with those in newly built cities and urban areas. Based on carefully selected and updated papers from the Silk Cities 2017 International Conference, this book appeals to researches, practitioners and policy makers.
    Type of Medium: Online Resource
    Pages: XIII, 268 p. 129 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030227623
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 89
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Transportation engineering. ; Traffic engineering. ; Sustainability. ; Political planning. ; Asia Economic conditions. ; Urban Sociology. ; Transportation Technology and Traffic Engineering. ; Sustainability. ; Public Policy. ; Asian Economics.
    Description / Table of Contents: Policy transfer as an emerging field of study -- Theoretical approaches to studying policy transfer -- Transport policy transfer in ‘Tiger Cub’ city-regions -- Sustainable urban transport in Southeast Asia: Making it happen.
    Abstract: By now, planners everywhere know - more or less - what the ingredients of a sustainable city are, in theory. The problem is that only bits of solutions are being implemented in the cities that most need them, the majority of which are located in the Global South. This book examines issues related to policy transfer in urban transport planning in Southeast Asia. The metropolitan regions of four major capitals - Jakarta, Kuala Lumpur, Manila, and Bangkok - are considered. The book assesses the in-bound and out-bound transfer of sustainable transport planning policies, concepts, and tools. The investigation focuses on who transfers policy and why, what elements of policy are transferred, in what direction and to what degree, and what barriers does transfer face. It also discusses how policy transfer processes in the transportation planning arena can be improved.
    Type of Medium: Online Resource
    Pages: XV, 121 p. 38 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030419752
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 90
    Keywords: Sociology, Urban. ; Demography. ; Population. ; Human geography. ; Economic geography. ; Social policy. ; Urban Sociology. ; Population and Demography. ; Human Geography. ; Economic Geography. ; Social Policy.
    Description / Table of Contents: Chapter1. Introduction -- Chapter2. A Policy Perspective on Shrinkage -- Chapter3. Rural shrinkage in a Nordic Welfare State -- Chapter4. Policy implications of rural depopulation -- Chapter5. Why do they fail? -- Chapter6. Arguments for a local adaptation policy.
    Abstract: This book builds on case studies in depopulating and shrinking areas in Northern Europe. While most contemporary literature on shrinkage focuses on these issues from a planning standpoint, this book uniquely applies a policy perspective when approaching the material. The book assesses the potential of demographic adaptation policies to manage depopulation, that is, policy programs aiming at managing depopulation through adaptation, rather than through growth policies intended to foster population growth. In 6 chapters, the book acts as an up-to-date resource on demographic adaptation for master and Ph.D. students, researchers, and practitioners working in local and regional development, governance, and planning. Chapter 1 gives an overview of recent demographic trends in Northern Europe and introduces the theoretical differences between growth policy and adaptation policy. Chapter 2 accounts for the policy concept and introduces a framework for how local adaptation policies could be systematically analysed. Chapter 3 suggests that the Nordic welfare states exhibit two characteristics that prove to be relevant when discussing the consequences and policy implications of demographic decline, i.e. an extremely sparse population structure and an ambitious welfare assignment that in many respects has been devolved to the local level of government. Chapter 4 suggests that whether shrinkage constitutes a problem or not depends upon the interpretations of those in power, but also upon political, economic and geographic conditions Chapter 5 seeks to understand why local level policymakers avoid developing strategies for how to handle long-term population decline. Chapter 6 summarizes the points of the previous chapters, and concludes that local governments in shrinking areas ought to develop local adaptation policies. These policies, however, also need to be subjected to critical analysis, and the chapter introduces a model for how local adaptation policy priorities could be assessed in a more structured manner. .
    Type of Medium: Online Resource
    Pages: X, 93 p. 6 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030340469
    Series Statement: SpringerBriefs in Geography,
    DDC: 307.76
    Language: English
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