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  • Books  (93)
  • Cham :Springer International Publishing :  (93)
  • IntechOpen
  • MDPI - Multidisciplinary Digital Publishing Institute
  • English  (93)
  • 571.6  (48)
  • 307.76  (45)
  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Biomedical engineering. ; Biotechnology. ; Biochemical engineering. ; Pharmaceutical chemistry. ; Vaccines Biotechnology. ; Biomaterials. ; Cell Biology. ; Biomedical Engineering and Bioengineering. ; Biotechnology. ; Bioprocess Engineering. ; Pharmaceutics. ; Biomaterials-Vaccines.
    Description / Table of Contents: Part I: Manufacturing of Recombinant Therapeutic Proteins -- Chapter 1. Single-Use Systems in Biopharmaceutical Manufacture: State of the Art and Recent Trends (Jossen et al.) -- Chapter 2. Recent Developments in Bioprocess Monitoring Systems (Rahmatnejad et al.) -- Chapter 3. Advances in Characterization of Industrial Bioreactors for Cell Culture Process (Fitschen et al.) -- Chapter 4. Continuous Bioprocessing for Upstream Process - Perfusion Process (Chotteau et al.) -- Chapter 5. Continuous Bioprocessing for Downstream (Gerstweiler) -- Chapter 6. Towards Digital Twin for Biopharmaceutical Processes: Concept and Progress (Ding et al.) -- Chapter 7. Integrated Process and Supply Chain Design and Optimization (Triantafyllou et al.) -- Chapter 8. Production of Complex Proteins in Plants – From Farming to Manufacturing (Nausch et al.) -- Chapter 9. Manufacturing of Recombinant Proteins Using Quality by Design (QbD) Methodology: Current Trend and Challenges (Shin and Landauer) -- Chapter 10. Biopharma 4.0 for Biologics Manufacturing Under Pandemic Constraints (Schmidt et al.) -- Chapter 11. Biopharma 4.0: Digital Technologies Driving Smart Manufacturing (Nargund et al.) -- Part II: Manufacturing Aspects of Cell and Gene Therapy -- Chapter 12. Essential Aspects of Mesenchymal Stem Cell Manufacturing (Fleischhammer et al.) -- Chapter 13. Towards a Continuous Production of Human Mesenchymal Stromal Cells in a Chemically Defined Medium: Opportunities and Challenges for a Robust and Scalable Expansion Process (Tasto and Salzig) -- Chapter 14. Biomanufacturing Aspects of Gene Therapy (Warnock) -- Chapter 15. Manufacturing and Quality of Advanced Therapeutics: Cellular Therapies, CAR-T and Gene Therapies (van den Bos et al.).
    Abstract: This volume “Cell Engineerring 11 - Biopharmaceutical Manufacturing: Progress, Trends and Challenges” is a source of the latest innovative research and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing productivity/efficiency, Model-assisted process understanding and development/Digital Twins, Process controls and analytics, Quality control, Quality by design, Facility design and full-scale commercial systems, manufacturing technology innovation. The book comprises contributions of experts from academia and industry active in the field of cell culture development for the production of recombinant proteins, cell therapy and gene therapy, with consideration of Digital Twin´s and facility design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. Inevitably, some omissions will occur in the test, but the authors have sought to avoid duplications by extensive cross-referencing to chapters in other volumes of this series and elsewhere. We hope the volume provides a useful compendium of techniques for scientists in industrial and research laboratories active in this field.
    Type of Medium: Online Resource
    Pages: IX, 495 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031456695
    Series Statement: Cell Engineering, 11
    DDC: 571.6
    Language: English
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  • 2
    Keywords: Cell adhesion. ; Cytology. ; Proteins . ; Cell Adhesion. ; Cell Biology. ; Protein Biochemistry.
    Description / Table of Contents: Part 1: Knockouts and animal models -- Integrins α1β1 and α2β1 – The generalist collagen receptors -- Roles for Integrin α3β1 in Development and Disease -- Part 2: Fibrosis& Cancer -- Integrins: Key targets in tissue fibrosis and tumor stroma -- Integrins in Cardiac Form, Function and Disease -- Integrin 8 and its ligand nephronectin in health and disease -- v integrin-dependent TGF activation in cancer: a brief update -- Part 3: Human disease -- a11b1, a mesenchymal collagen-binding integrin with a central role in tissue- and tumor fibrosis -- Integrins in pathological tissue remodelling of joints -- α4 integrins in immune homeostasis and disease -- β2-integrins in immunity: new roles for old players -- Structure and function of the leukocyte integrin αMβ2 -- Part 4: Integrins in hemostasis, and immune control -- Platelet integrins: Critical mediators of haemostasis and pathological thrombus formation -- Integrins as receptors for bacterial and viral pathogens.
    Abstract: Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find “Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions” authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: XII, 472 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031237812
    Series Statement: Biology of Extracellular Matrix, 13
    DDC: 571.6
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Bioinformatics. ; Imaging systems in biology. ; Cell Biology. ; Computational and Systems Biology. ; Biological Imaging.
    Description / Table of Contents: Introduction -- Batch Processing Methods in ImageJ -- Python: Data Handling, Analysis and Plotting -- Building a Bioimage Analysis Workflow Using Deep Learning -- GPU-Accelerating ImageJ Macro Image Processing Workflows Using CLIJ -- How to Do the Deconstruction of Bioimage Analysis Workflows: A Case Study with SurfCut -- i.2.i. with the (Fruit) Fly: Quantifying Position Effect Variegation in Drosophila Melanogaster -- A MATLAB Pipeline for Spatiotemporal Quantification of Monolayer Cell Migration.
    Abstract: This open access textbook aims at providing detailed explanations on how to design and construct image analysis workflows to successfully conduct bioimage analysis. Addressing the main challenges in image data analysis, where acquisition by powerful imaging devices results in very large amounts of collected image data, the book discusses techniques relying on batch and GPU programming, as well as on powerful deep learning-based algorithms. In addition, downstream data processing techniques are introduced, such as Python libraries for data organization, plotting, and visualizations. Finally, by studying the way individual unique ideas are implemented in the workflows, readers are carefully guided through how the parameters driving biological systems are revealed by analyzing image data. These studies include segmentation of plant tissue epidermis, analysis of the spatial pattern of the eye development in fruit flies, and the analysis of collective cell migration dynamics. The presented content extends the Bioimage Data Analysis Workflows textbook (Miura, Sladoje, 2020), published in this same series, with new contributions and advanced material, while preserving the well-appreciated pedagogical approach adopted and promoted during the training schools for bioimage analysis organized within NEUBIAS – the Network of European Bioimage Analysts. This textbook is intended for advanced students in various fields of the life sciences and biomedicine, as well as staff scientists and faculty members who conduct regular quantitative analyses of microscopy images.
    Type of Medium: Online Resource
    Pages: X, 212 p. 265 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030763947
    Series Statement: Learning Materials in Biosciences,
    DDC: 571.6
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Sustainability. ; Property. ; Common law. ; Education. ; Urban Sociology. ; Sustainability. ; Common Property and Land Law. ; Education.
    Description / Table of Contents: Part 1: Objectives, Substantive Issues and Structure of This Book -- Chapter 1. Scientific, knowledgeable background and Book Architecture -- Part 2: Urban Informality Transitions in the Middle East’s Cities -- Chapter 2. Governance and Sustainability Transitions on Urban Informality -- Chapter 3. Urbanization and Informality in the Era of Globalization -- Chapter 4. The Paradigm of Urban Informality: Laws, Norms, and Practices -- Chapter 5. State, Society, Economy, and Housing Informality -- Chapter 6. Land Rights, Governance and Urban Informality -- Chapter 7. Spatial Divide, Marginality, Social Exclusion, Social Cohesion, and Urban Informality -- Part 3: Cross-Regional Scene -- Chapter 8. A Puzzle of Urban Sustainability Transitions on Urban Informality in Egypt -- Chapter 9. The Pockets of Urban Informality in Lebanon -- Chapter 10. Hills of Urban Informality in Greater Amman, Jordan -- Part 4: Epilogue -- Chapter 11. A Credible Future.
    Abstract: This book develops an analytical framework for a serious investigation of the historical specificities of cities of the Global South within three Mediterranean areas and inland territories. Its starting point is the research on urban informality in three different environments; one has experienced tremendous socio-economic transformation, while the other two have experienced the conflict that occurred in the Middle East under a free-market-oriented imposed system. The book provides a unique overview of urban informality within the region. This book draws upon experience and intensive work on the definitions and taxonomies of urban informality in the Global South. It investigates urban informality as a site of transitions in different socioeconomic, socio-spatial, and political contexts, concerning theories and practice, to strengthen understanding of sustainable transition processes. It explores how urban informality operates in the context of comparative cross-national perspectives that meet the SDGs and the NUA. The book enables policymakers, planners, and designers to think about urban informality as a dynamic multi-dimensional phenomenon, or as a site of transitions, within a built environment embedded in specific contexts. It arrives at the full package of resilient benefits provided by urban informality and even the different basic ways in which a better way of life can become manifest. This book opens a new scientific discussion between urban informality and sustainability transition perspectives, between conceptual and empirical, and between structural and practical. Geoffrey Payne, Geoffrey Payne and Associates It is often assumed that informality is simply the opposite of formality – a binary structure of opposites. However, the academic literature has exposed it as far more layered and complex than this and the analysis by Professor Soliman demonstrates convincingly and comprehensively, the multi-layered nature of urban informality in Egypt and the Middle East in general. Overlapping legal forms of land tenure and property rights, together with variations both within as well as between settlements, make it vital to understand this complexity in order that policies to address it are evidence based. This book offers a synopsis of urban informality in the Middle East, ongoing research on the governance of sustainability transitions and how to deal with urban informality in the context of sustainability transitions. This provides an essential foundation for understanding the complexity of informality, reasons why it exists, the positive as well as negative features and the options for reducing it. It is essential reading for all involved in addressing the issue in a region of the world where the relationship between formal and informal development of land and housing is critical to social and economic development.
    Type of Medium: Online Resource
    Pages: XXIII, 450 p. 56 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030689889
    DDC: 307.76
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Bioinformatics. ; Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Bioinformatics.
    Description / Table of Contents: Brain Tissue Oxygen and BOLD fMRI Under Different Levels Of Neuronal Activity -- Cerebral Microcirculation and Oxygenation Modulation by Transcranial Alternating Current Stimulation in Awake and Anesthetized Mice -- The Effect of Hypercapnia on Cortical Metabolic Rate and Mitochondrial Redox Status -- Relationship Between Left-Right Dominancy of Prefrontal Cortex Activity and Heart Rate During Rest and Task Periods: An fNIRS Study -- Relationship Between Cognitive Function, Oral Conditions and Systemic Metabolic Function in the Elderly -- Pro-survival Phenotype of HIF-1α: Neuroprotection through Inflammatory Mechanisms -- Infradian Rhythms in Cerebrovascular Oxygenation and Blood Volume in Humans at Rest: A 5-year Study -- Mechanisms of Photostimulation of Brain’s Waste Disposal System: the Role of Singlet Oxygen -- Changes of Arterial and Venous Cerebral Blood Flow Correlation in Moderate-to-Severe Traumatic Brain Injury: A CT Perfusion Study -- Cerebral Net Water Uptake in Posttraumatic Cerebral Ischemia -- Brainstem Damage Underlies Changes in Hypoxic Ventilatory Response following Cardiac Arrest and Resuscitation in Rats -- Differences Between Good, Moderate and Poor Performers of a Verbal Fluency Task under Blue Light Exposure: An SPA-fNIRS Study -- Sex-specific and Dose-dependent Effects of Drag-Reducing Polymers on Microcirculation and Tissue Oxygenation in Rats after Traumatic Brain Injury -- Accuracy of Tissue Oxygen Saturation Measurements of a Textile-based NIRS Sensor -- Understanding the Role of Caveolae in Oxygen Buffering: The Effect of Membrane Curvature -- The Significance of Lipids for the Absorption and Release of Oxygen in Biological Organisms -- How Skin Color Depends on Tissue Oxygenation -- Tissue Concentration Analysis of Sulfur, Calcium and Oxygen in novel Skin Primo Nodes After Acupuncture -- Primo Vessels Inside Lymphatic Vessels are Absent in an ALS Mouse Model -- The Impact of Heterogeneous Cell Density in Hypoxic Tumors Treated with Radiotherapy -- A Critical Analysis of Possible Mechanisms for the Oxygen Effect in Radiation Therapy with FLASH -- Hyperhydration of Cancers: A Characteristic Biophysical Trait Strongly Increasing O2, CO2, Glucose and Lactate Diffusivities, and Improving Thermophysical Properties of Solid Malignancies -- No Difference in Muscle Basal Oxygenation in a Bedridden Population pre and Post Rehabilitation -- Relationship between Muscle Deoxygenation and Cardiac Output in Subjects without Attenuation of Deoxygenation Hemoglobin Concentration near the end of Ramp Cycling Exercise: A Longitudinal Study -- Image Reconstruction Using Deep Learning for Near-Infrared Optical Tomography: Generalization Assessment -- Neonatal Brain Temperature Monitoring Based on Broadband Near-Infrared Spectroscopy -- Time Domain Near-Infrared Optical Tomography Utilizing Full Temporal Data: A Simulation Study -- BIAN: A Multilayer Microfluidic-Based Tissue-Mimicking Phantom for Near-Infrared Imaging -- Do Vascular and Extracellular Measurements Consistently Reflect Intracellular pO2? Observation of Tissue Oxygenation Changes using Remote Photoplesysmography with a Smartphone -- Neurovascular, Metabolic, and Glymphatic Dynamics of the Brain Measured with fNIRS -- Imaging Cerebral Blood Vessels Using Near-Infrared Optical Tomography: A Simulation Study -- Reduced Cerebrovascular Oxygenation in Individuals with Post-Acute COVID-19 Syndrome (PACS) (“Long COVID”) -- Insufficient Oxygen Supplementation During Cardiopulmonary Resuscitation Leads to Unfavorable Biological Response While Hyperoxygenation Contributes to Metabolic Compensation -- Block of the Angiotensin Pathways Affects Flow-Volume Spirometry in Patients With SARS-CoV-2 Infection -- A Prospective Observational Pilot Study on the Effects of the Activity-based Stress Release Program on the Mental State and Autonomic Nervous System in Psychiatric patients. .
    Abstract: This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 49th annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2022). Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource.
    Type of Medium: Online Resource
    Pages: XIX, 240 p. 91 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031420030
    Series Statement: Advances in Experimental Medicine and Biology, 1438
    DDC: 571.6
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sociology, Urban. ; Geography. ; Economic geography. ; Political planning. ; Urban Sociology. ; Geography. ; Economic Geography. ; Public Policy.
    Description / Table of Contents: Introduction -- Chapter 1. The Urban, Spas And Maritime Vilegiatura -- Chapter 2. The Metropolises Grow Towards The Sea, Northeast Of Brazil -- Chapter 3. Coastal Metropolitization And Tourist Real Estate -- Chapter 4. The Social And Urbanistic Effects Of Tourism Developments In Fortaleza, Brazil -- Conclusion.
    Abstract: This book intends to present the development of socio-spatial practices in the metropolitan coast of the Northeast of Brazil, highlighting the main urban, spa and tourist agglomerations: Salvador-BA, Recife-PE, Fortaleza-CE, and Natal-RN. The objective is to study the processes of urbanization associated with maritime leisure. In the first chapter, the reader will find a historical and conceptual presentation highlighting the relevance of leisure practices, their forms-flows and their role in the formation of maritime resorts. The second chapter analyses the context of the northeastern region of Brazil and demonstrates the process of modernization and formation of the seaside function within the cities, and later, in the maritime metropolises of the region. The relationship between urbanization and touristic real estate ventures is the central theme of the third chapter, which proposes a specific methodology for studies of this nature. The final chapter presents the seaside resorts in the metropolitan area of Fortaleza, a case study similar to others in the Northeast, examining the urbanistic effects and the key ideas of the planners.
    Type of Medium: Online Resource
    Pages: IX, 74 p. 19 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030465933
    Series Statement: SpringerBriefs in Latin American Studies,
    DDC: 307.76
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Urban policy. ; Agriculture. ; Social justice. ; Urban Policy. ; Agriculture. ; Social Justice.
    Description / Table of Contents: Introduction -- Part I: A Political Ecology Lens -- Chapter 1. Vulnerable, Yet Resilient -- Part Ii: Social Networks And Access To Resources -- Chapter 2. Urban Food System Concepts -- Part Iii: Solutions Without Resolution -- Chapter 3. Land, Knowledge, Strategies -- Postscript: Final Reflection -- References.
    Abstract: This book explores how power relationships, measured through qualitative social network analysis, impact planning participation and livelihood strategies of a marginalized group of farmers cultivating the Yamuna River floodplain in Delhi, India. Through an in-depth study of 165 farming households facing land development, this book offers insights from the ground-up into how social dynamics enable and constrain agency. A novel mixed-methods approach was used to measure social networks and access to resources based on the different types of people farmers might interact with as part of their livelihoods: hired laborers, vendors, other farmers, etc. Digging deeper into social network patterns, typologies of power are illustrated as they manifest household agency through diverse pathways. More broadly, a political ecology lens is used to link together the multiple and fragmented Yamuna farmers’ stories with broader social, ecological, infrastructural, and economic contexts to suggest future directions for inquiry and policy related to localized urban food systems and sustainable development. This monograph will be of interest to academic faculty and graduate students in critical geography, cultural anthropology, food studies, landscape architecture/urban planning, and sociology. .
    Type of Medium: Online Resource
    Pages: XXIII, 276 p. 36 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031263804
    Series Statement: Cities and Nature,
    DDC: 307.76
    Language: English
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  • 8
    Keywords: Urban policy. ; Sustainability. ; Architecture. ; Urban Policy. ; Sustainability. ; Cities, Countries, Regions.
    Description / Table of Contents: Part 1: Tourism dynamics in urban city centres -- Towards resilient urbanism in tourist cities: post-pandemic challenges -- The pain of being a resident in Granada. Analysis of the accommodation offer and residents´ perception -- Recent socio-spatial transformations in the San Pedro neighbourhood (Santiago de Compostela) -- The touristification of historic centres through commercial gentrification in times of Covid-19 -- Citizen resistance in touristified neighborhoods. A post-pandemic análisis -- Neoliberalism, collaborative economy, and short-term rentals regulation in Andalusia, Spain -- Changes in the role of heritage in historic centres: the mutation of historic buildings into tourist accommodation -- Part 2: Urban-tourist spaces on the coast: New urbanised spaces and resistance -- Urban-tourism spaces on the coast: transformations, challenges and globalisation in uncertain scenarios -- Landscape preservation on the Mediterranean coast; do social movements play a decisive role? The case of the Costa Brava (Spain) -- The construction of sustainable territorial models in the aftermath of the Covid-19 pandemic: Lessons from medium-sized Mediterranean cities -- Housing change during the Covid-19 pandemic in the metropolitan areas of the Canary Island capitals (Spain) -- Two megaprojects – One city. Learning between large-scale urban development projects on Tenerife, Spain -- Touristification process in seaside destination inland: The case of Mallorca Island, Spain -- Part 3: Urban transformations: New dynamics, conflicts and challenges in a context of uncertainty -- Towards urban degrowth? Urban planning as a common thread of contradictory dynamics in cities -- Shrinking cities in Spain: Shrinking medium-sized cities in the 21st century. Depopulation and employment -- The peripheries of Spanish developmentalism. an enduring model of urban fragmentation -- Housing, a problem perpetuated over time in Spain. New initiatives to promote access to affordable housing in Madrid -- Residential expectations in a neoliberal perspective: A sociological view of social classes and the right to housing -- (Re)thinking gentrification processes. The place of religion -- Metropolitan spatial reconfiguration and the mobility transition: Sustainability challenges in the fragmented city -- Sustainability and urban development strategies: Ciudad Real -- Part 4: Postscript -- Intra-urban borders in border cities: The nationally interchangeable dynamics of urban centrality.
    Abstract: This book offers a unique perspective on urban processes affecting tourist spaces and city centres. Economic, social and environmental uncertainty has been commonplace since March 2019, when mobility slowed down across the globe. The COVID-19 pandemic accelerated trends that have been investigated in urban space for years. The incorporation of technologies, the expansion of tourism and the introduction of policies that in part want to advance sustainability are generating processes of reorganisation of territories that are driving changes. These changes will affect models of city, urbanism and society. This publication is directed to a wide spectrum of people interested in urban processes, tourism and social change in the context of the Post-Pandemic Covid-19. In particular, the book is aimed at researchers, undergraduate and postgraduate students, consultants, public administrations and the public interested in the recent challenges that are affecting developed and developing societies.
    Type of Medium: Online Resource
    Pages: XII, 371 p. 103 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031360176
    Series Statement: The Urban Book Series,
    DDC: 307.76
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Neurosciences. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Cell Biology. ; Neuroscience. ; Biomedical Research. ; Pharmacology.
    Description / Table of Contents: A historical and evolutionary view of tight junctions -- Tricellular tight junctions -- Mechanosensitivity of tight junctions -- Intracellular traffic and non-canonical roles of ZO-2 protein -- Impact of claudin-2 and occludin expression in inflammation disorders -- Tight junctions in the inflamed gut -- Intestinal barrier disruption by enteropathogenic Escherichia coli -- Tight junction barrier function regulation by microbiota -- Claudin-7 participation in cell-substrate adhesion, cell migration, salt balance in the renal collecting duct and gut cell renewal and differentiation -- Regulation of the alveolar epithelial barrier by claudin-5 -- Regulation of the blood-retinal barrier by occludin phosphorylation, norrin and sonic hedgehog signaling -- Transmigration of metastatic cells through the blood-brain barrier -- Endocytosis of tight junction proteins -- Regulated degradation of claudins. .
    Abstract: This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells. The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of an array of knock out mice. The chapters also explore in-depth studies of tight junctions in specific tissues (gut, lung and endothelia). This book offers a comprehensive understanding on post-translational modifications of occludin and its impact on tight junction function, as well as the molecular composition and function of tricellular tight junctions. This volume is particularly relevant to students and scientists in neuroscience, cell biology, physiology, cell differentiation, and cancer research.
    Type of Medium: Online Resource
    Pages: XII, 334 p. 47 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030972042
    DDC: 571.6
    Language: English
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  • 10
    Keywords: Cytology. ; Neurosciences. ; Immunology. ; Medicine Research. ; Biology Research. ; Cancer. ; Cell Biology. ; Neuroscience. ; Immunology. ; Biomedical Research. ; Cancer Biology.
    Description / Table of Contents: Part I. Cancer -- Ubiquitin-Regulated Cell Proliferation and Cancer -- Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer -- The Proteasome System in Health and Disease -- Proteostasis Dysregulation in Pancreatic Cancer -- Divergent Modulation of Proteostasis in Prostate Cancer -- Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma -- Part II. Neurodegeneration -- Altered Proteostasis in Neurodegenerative Tauopathies -- The Ubiquitin System in Alzheimer’s Disease -- The Interplay Between Proteostasis Systems and Parkinson’s Disease -- Machado–Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides -- Part III. Infection, Inflammation and Developmental Disorders -- SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends -- The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication -- By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System -- TRIM E3 Ubiquitin Ligases in Rare Genetic Disorders -- Part IV. Diet -- We Are What We Eat: Ubiquitin–Proteasome System (UPS) Modulation Through Dietary Products.
    Abstract: This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
    Type of Medium: Online Resource
    Pages: XII, 348 p. 42 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030382667
    Series Statement: Advances in Experimental Medicine and Biology, 1233
    DDC: 571.6
    Language: English
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