Publication Date:
2008-10-18
Description:
Conventional magnetic resonance methods that provide interior temperature profiles, which find use in clinical applications such as hyperthermic therapy, can develop inaccuracies caused by the inherently inhomogeneous magnetic field within tissues or by probe dynamics, and work poorly in important applications such as fatty tissues. We present a magnetic resonance method that is suitable for imaging temperature in a wide range of environments. It uses the inherently sharp resonances of intermolecular zero-quantum coherences, in this case flipping up a water spin while flipping down a nearby fat spin. We show that this method can rapidly and accurately assign temperatures in vivo on an absolute scale.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080759/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080759/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galiana, Gigi -- Branca, Rosa T -- Jenista, Elizabeth R -- Warren, Warren S -- EB2122/EB/NIBIB NIH HHS/ -- EB5979/EB/NIBIB NIH HHS/ -- R01 EB002122/EB/NIBIB NIH HHS/ -- R01 EB002122-22A2/EB/NIBIB NIH HHS/ -- New York, N.Y. -- Science. 2008 Oct 17;322(5900):421-4. doi: 10.1126/science.1163242.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18927389" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Body Temperature
;
Lipids
;
Magnetic Resonance Imaging/*methods
;
Mice
;
Mice, Obese
;
*Temperature
;
Water
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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