Publication Date:
1982-08-27
Description:
Cellular genes potentially capable of inducing oncogenic transformation have been identified by homology to the transforming genes of retroviruses and by the biological activity of cellular DNA's in transfection assays. DNA's of various tumors induce transformation with high efficiencies, indicating that oncogenesis can involve dominant genetic alterations resulting in activation of cellular transforming genes. The identification and characterization of cellular transforming genes and their possible involvement in naturally occurring cancers, is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cooper, G M -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):801-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6285471" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
*Cell Transformation, Neoplastic
;
Cells, Cultured
;
Chick Embryo
;
DNA/genetics
;
DNA Restriction Enzymes
;
DNA, Viral/genetics
;
Gene Expression Regulation
;
*Genes
;
Genes, Viral
;
Humans
;
Mice
;
Neoplasms/*genetics
;
Oncogene Protein pp60(v-src)
;
Rats
;
Retroviridae/*genetics
;
Transfection
;
Viral Proteins/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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