ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

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How to clean up the Ganges? (2018)

Shah, T., Ray, C., Lele, U.

American Association for the Advancement of Science (AAAS)

In: Science

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Publication Date: 2018

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

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Protecting entangled pairs (2018)

Osborne, I. S.

American Association for the Advancement of Science (AAAS)

In: Science

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Publication Date: 2018

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

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Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN (2018)

Sievers, Q. L., Petzold, G., Bunker, R. D., Renneville, A., Słabicki, M., Liddicoat, B. J., Abdulrahman, W., Mikkelsen, T., Ebert, B. L., Thomä, N. H.

American Association for the Advancement of Science (AAAS)

In: Science

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Publication Date: 2018

Description: 〈p〉The small molecules thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) by recruiting a Cys〈sub〉2〈/sub〉-His〈sub〉2〈/sub〉 (C2H2) zinc finger domain to Cereblon (CRBN), the substrate receptor of the CRL4〈sup〉CRBN〈/sup〉 E3 ubiquitin ligase. We screened the human C2H2 zinc finger proteome for degradation in the presence of thalidomide analogs, identifying 11 zinc finger degrons. Structural and functional characterization of the C2H2 zinc finger degrons demonstrates how diverse zinc finger domains bind the permissive drug-CRBN interface. Computational zinc finger docking and biochemical analysis predict that more than 150 zinc fingers bind the drug-CRBN complex in vitro, and we show that selective zinc finger degradation can be achieved through compound modifications. Our results provide a rationale for therapeutically targeting transcription factors that were previously considered undruggable.〈/p〉

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

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Stress in Neanderthal children (2018)

Aldenderfer, M.

American Association for the Advancement of Science (AAAS)

In: Science

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Publication Date: 2018

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

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Moments to spare (2018)

Voosen, P.

American Association for the Advancement of Science (AAAS)

In: Science

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Publication Date: 2018

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

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Engaging community with humility (2018)

Delborne, J., Kokotovich, A., Barnhill-Dilling, S. K.

American Association for the Advancement of Science (AAAS)

In: Science

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Publication Date: 2018

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

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East Asian hydroclimate modulated by the position of the westerlies during Termination I (2018)

Zhang, H., Griffiths, M. L., Chiang, J. C. H., Kong, W., Wu, S., Atwood, A., Huang, J., Cheng, H., Ning, Y., Xie, S.

American Association for the Advancement of Science (AAAS)

In: Science

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Publication Date: 2018

Description: 〈p〉Speleothem oxygen isotope records have revolutionized our understanding of the paleo East Asian monsoon, yet there is fundamental disagreement on what they represent in terms of the hydroclimate changes. We report a multiproxy speleothem record of monsoon evolution during the last deglaciation from the middle Yangtze region, which indicates a wetter central eastern China during North Atlantic cooling episodes, despite the oxygen isotopic record suggesting a weaker monsoon. We show that this apparent contradiction can be resolved if the changes are interpreted as a lengthening of the Meiyu rains and shortened post-Meiyu stage, in accordance with a recent hypothesis. Model simulations support this interpretation and further reveal the role of the westerlies in communicating the North Atlantic influence to the East Asian climate.〈/p〉

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An ironclad role in metastasis (2018)

Kiberstis, P. A.

American Association for the Advancement of Science (AAAS)

In: Science

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Publication Date: 2018

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Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

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Poly(ADP-ribose) drives pathologic {alpha}-synuclein neurodegeneration in Parkinsons disease (2018)

Kam, T.-I., Mao, X., Park, H., Chou, S.-C., Karuppagounder, S. S., Umanah, G. E., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., Andrabi, S. A., Qi, C., Poirier, G. G., Pletnikova, O., Troncoso, J. C., Bekris, L. M., Leverenz, J. B., Pantelyat, A.,

American Association for the Advancement of Science (AAAS)

In: Science

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Publication Date: 2018

Description: 〈p〉The pathologic accumulation and aggregation of α-synuclein (α-syn) underlies Parkinson’s disease (PD). The molecular mechanisms by which pathologic α-syn causes neurodegeneration in PD are not known. Here, we found that pathologic α-syn activates poly(adenosine 5'-diphosphate–ribose) (PAR) polymerase-1 (PARP-1), and PAR generation accelerates the formation of pathologic α-syn, resulting in cell death via parthanatos. PARP inhibitors or genetic deletion of PARP-1 prevented pathologic α-syn toxicity. In a feed-forward loop, PAR converted pathologic α-syn to a more toxic strain. PAR levels were increased in the cerebrospinal fluid and brains of patients with PD, suggesting that PARP activation plays a role in PD pathogenesis. Thus, strategies aimed at inhibiting PARP-1 activation could hold promise as a disease-modifying therapy to prevent the loss of dopamine neurons in PD.〈/p〉

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Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

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Steps to smaller rings (2018)

Yeston, J.

American Association for the Advancement of Science (AAAS)

In: Science

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Publication Date: 2018

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

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