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  • Articles  (367,972)
  • Articles: DFG German National Licenses  (367,972)
  • Chemistry  (366,189)
  • Analytical Chemistry and Spectroscopy  (21,541)
  • Biochemistry  (1,827)
  • Chemistry and Pharmacology  (367,972)
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  • Articles  (367,972)
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Keywords
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Topic
  • 1
    Electronic Resource
    Electronic Resource
    Chemical and electrochemical approaches to the investigation of redox reactions of simple electron transfer metalloproteins
    Amsterdam : Elsevier
    Inorganica Chimica Acta 226 (1994), S. 293-340 
    Details
    ISSN: 0020-1693
    Keywords: Chemistry ; Electrochemistry ; Electron transfer ; Metalloproteins ; Redox reactions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0020-1693(94)04082-6
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  • 2
    Electronic Resource
    Electronic Resource
    Biochemistry at the University of Zambia
    Amsterdam : Elsevier
    International Journal of Biochemistry 2 (1971), S. 457-461 
    Details
    ISSN: 0020-711X
    Keywords: Biochemistry ; Zambia ; cancer ; casein polymorphism ; computer simulation ; nutritional surveys ; steroid hormones ; trace elements
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0020-711X(71)90083-8
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  • 3
    Electronic Resource
    Electronic Resource
    Biochemistry in hungary - a review
    Amsterdam : Elsevier
    International Journal of Biochemistry 4 (1973), S. 1-15 
    Details
    ISSN: 0020-711X
    Keywords: Biochemistry ; Hungary ; enzymes ; membranes ; muscle ; nucleic acids ; plant biochemistry ; regulation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0020-711X(73)90015-3
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  • 4
    Electronic Resource
    Electronic Resource
    The consequences of the mutual recognition of measurement standards for international metrology (2000)
    Springer
    Accreditation and quality assurance 5 (2000), S. 409-413 
    Details
    ISSN: 1432-0517
    Keywords: Key words Metrology ; Comparisons ; Chemistry ; Standards
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  After stressing the importance in the modern world of accurate and reproducible measurements, the actions taken by the Bureau International des Poids et Mesures to set up, together with the regional metrology organizations, a series of key comparisons are described. They are the technical foundation of a mutual recognition of national measurement standards arrangement prepared in conjunction with the National Metrology Institutes (NMIs). This arrangement also includes the recognition of calibration and measurement certificates issued by these institutes. Then, the consequences of this arrangement for trade are described. The case of chemical analysis is illustrated by the application of the Kyoto protocol on the reduction of greenhouse gases. But the global workload to be taken up by the International Committee of Weights and Measures, its Consultative Committee for Amount of Substance and the NMIs is huge.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007690000228
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  • 5
    Electronic Resource
    Electronic Resource
    Histamine receptors in the central nervous system (1989)
    Springer
    Pharmacy world & science 11 (1989), S. 146-150 
    Details
    ISSN: 1573-739X
    Keywords: Agonists ; Antagonists ; Biochemistry ; Central nervous system ; Ligands ; Pharmacology ; Receptors, histamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The role of histamine in brain function is discussed. A brief review is presented on the three types of histamine receptors with regard to their biochemistry and functions, as well as on specific ligands, both agonists and antagonists. It is concluded that several aspects of the pharmacology of histamine in the central nervous system are still a matter of empirism and speculations. The recent publications on the brain-penetrating H2 antagonist zolantidine and the selective H3 agonists and antagonists are expected to contribute to the knowledge of the histaminergic pathways in the brain. Therapeutical areas within the central nervous system are related to behaviour (including wake-sleep), neuroendocrinal processes, the control of muscle activity and cerebral circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959461
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacochemical aspects of leprosy (1989)
    Springer
    Pharmacy world & science 11 (1989), S. 3-8 
    Details
    ISSN: 1573-739X
    Keywords: Biochemistry ; Clofazimine ; Dapsone ; Ethionamide ; Isoniazide ; Mechanism of action ; Mycobacterium leprae ; Prothionamide ; Quinolones ; Ribonucleotide reductase inhibitors ; Rifampicin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract From a pharmacochemical point of view the existing anti-leprotics as well as possible innovations in the chemotherapy of leprosy are discussed. Of the main anti-leprotics, which are used nowadays — dapsone, rifampicin, clofazimine, isoniazide, ethionamide and prothionamide — the mechanism of action, the main problems in their application and possibilities to develop improved variants are reviewed. Based on the chemistry ofMycobacterium leprae, the target systems for new anti-leprotics are identified. These systems include the cell wall, the catabolism of reactive oxygen species, the metabolisms of carbon sources, the amino acid metabolism and the uptake of iron. Two possible new lead structures from other fields, 4-quinolones and mycobacterial ribonucleotide reductase inhibitors are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972907
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  • 7
    Electronic Resource
    Electronic Resource
    Progress in the research of artemisinin-related antimalarials: An update (1994)
    Springer
    Pharmacy world & science 16 (1994), S. 169-180 
    Details
    ISSN: 1573-739X
    Keywords: Antimalarials ; Artemisia annua L ; Artemisinin ; Biosynthesis ; Chemistry ; Clinical trials ; Pharmacology ; Phytochemistry ; Sesquiterpenes ; Toxicology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Artemisinin, a sesquiterpene lactone endoperoxide isolated fromArtemisia annua L., and a number of its semisynthetic derivatives have shown to possess antimalarial properties. They are all eflective againstPlasmodium parasites that are resistant to the newest and commonly used antimalarial drugs. This article gives a survey of the literature dealing with artemisinin-relaled antimalarial issues that have appeared from the end of 1989 up to the beginning of 1994. A broad range of medical and pharmaceutical disciplines is covered, including phytochemical aspects like the selection of high-producing plants, analytical procedures, and plant biotechnology. Furthermore, the organic synthesis of artemisinin derivatives is discussed, as well as their mechanism of action and antimalarial activity, metabolism and pharmacokinetics, clinical studies, sideeffects and toxicology, and biological activities other than antimalarial activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01872865
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  • 8
    Electronic Resource
    Electronic Resource
    The beta-adrenoceptor-adenylate cyclase complex (1986)
    Springer
    Pharmacy world & science 8 (1986), S. 209-222 
    Details
    ISSN: 1573-739X
    Keywords: Biochemistry ; Pharmacology ; Receptors, adrenergic, beta ; Review
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Developments in the receptor concept have greatly influenced our current knowledge of the beta-adrenoceptor. The triad of pharmacology, organic chemistry and studies in structure-activity relationships is discussed along historical lines, as it has been and still is an impetus for progress in the biochemistry of ligand-receptor interactions. With respect to the beta-adrenoceptor complex these advances which have led to a model in which three protein structures are functionally interacting within the frame of the cell wall: the beta-adrenoceptor, the regulatory guanine nucleotide binding protein, and the enzyme adenylate cyclase, are reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957781
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  • 9
    Electronic Resource
    Electronic Resource
    Abstracts of Dutch doctoral theses (1988)
    Springer
    Pharmacy world & science 10 (1988), S. 93-95 
    Details
    ISSN: 1573-739X
    Keywords: Anthracyclines ; Chemistry ; Drug stability ; Mitomycins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01962686
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  • 10
    Electronic Resource
    Electronic Resource
    Etoposide and teniposide (1988)
    Springer
    Pharmacy world & science 10 (1988), S. 101-116 
    Details
    ISSN: 1573-739X
    Keywords: Chemistry ; Chromatography ; Etoposide ; Immunoassay ; Metabolism ; Podophyllotoxin ; Pharmacokinetics ; Teniposide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Etoposide (VP 16-213) and teniposide (VM 26) are semisynthetic epipodophyllotoxin derivatives active against a variety of tumours. The clinical efficacy has led to an increasing interest in these compounds. This review presents information on the mechanism of action, biochemical pharmacology, bioanalysis, metabolism and pharmacokinetics of etoposide and teniposide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959294
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