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1

Digitale Medien

Nature Medicine 2.0 (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 1-1

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In the future, Nature Medicine will be famous to 15 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0107-1

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2

Digitale Medien

Human T H 17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation (2007)

Kebir, Hania ; Kreymborg, Katharina ; Ifergan, Igal ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 1173-1175

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] TH17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1651

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3

Digitale Medien

In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' (2007)

Hatfield, Alan ; Owen, Samantha ; Pilot, Paul Richard

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 13-13

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor: The recent article by Kerkelä et al. reported clinical findings of congestive heart failure (CHF) in ten patients, and preclinical studies showing that imatinib-treated mice can develop left ventricular contractile dysfunction and cellular abnormalities suggestive of a toxic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0107-13a

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4

Digitale Medien

In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' (2007)

Atallah, Ehab ; Kantarjian, Hagop ; Cortes, Jorge

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 14-14

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor: We read with interest the article of Kerkelä et al. discussing the potential cardiotoxicity of imatinib mesylate in animal models and detailing ten patients, nine from our institution, who developed congestive heart failure (CHF) on imatinib therapy. This report has generated ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0107-14

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5

Digitale Medien

Is leptin an important physiological regulator of CRP? (2007)

Hutchinson, Winston L ; Coll, Anthony P ; Gallimore, J Ruth ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 17-18

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the Editor: Binding between C-reactive protein (CRP) and human leptin in vitro, and inhibition by CRP of the effects of human leptin in mice in vivo, have recently been reported by Chen et al.. In their in vitro studies the authors showed that after exposure of leptin-coupled agarose beads to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0107-17

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6

Digitale Medien

The Young and the Restless (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 649-649

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The issue of aging academics in times of budgetary constraints has stirred vigorous debate. Many older professors continue to be productive researchers and inspiring teachers with plenty of wind in their sails. However, some say the abundance of older professors is clogging an already narrow ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0607-649

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7

Digitale Medien

Emergency trials of blood substitutes skirt ethical questions (2007)

Anderson, Andrea

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 652-652

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Did you wear a thick, blue plastic bracelet with the words “I decline the Northfield PolyHeme study” splashed across it in bold black writing during the years 2004 to 2006?... If not, and had you been in a serious accident during that time, you could have been unwittingly enrolled in a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0607-652

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8

Digitale Medien

Sluggish approvals blocking Africans' access to bed nets (2007)

Marris, Emma

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 651-651

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In the fight against malaria, long-lasting insecticidal bed nets—made from polyester or plastic and treated with insecticides—are a favorite tool. Because they can be washed and reused for years, donors such as the Roll Back Malaria Partnership push for their use.... But the nets are ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0607-651

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9

Digitale Medien

London hospital launches infectious disease 'biobank' (2007)

Towie, Narelle

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 653-653

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] British doctors have begun collecting samples for Britain's first storehouse of infectious diseases, two years after the launch of the UK's ambitious BioBank project.... Following nearly a year of discussion over ethical approval, Guy’s & St Thomas’ hospital in London has a £45 million ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0607-653a

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10

Digitale Medien

Chromosome 5q deletion and epigenetic suppression of the gene encoding α-catenin ( CTNNA1 ) in myeloid cell transformation (2007)

Liu, Ting Xi ; Becker, Michael W ; Jelinek, Jaroslav ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 78-83

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Interstitial loss of all or part of the long arm of chromosome 5, or del(5q), is a frequent clonal chromosomal abnormality in human myelodysplastic syndrome (MDS, a preleukemic disorder) and acute myeloid leukemia (AML), and is thought to contribute to the pathogenesis of these diseases by deleting ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1512

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11

Digitale Medien

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors (2007)

Rousseaux, Christel ; Thuru, Xavier ; Gelot, Agathe ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 35-37

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of μ-opioid and cannabinoid receptors in intestinal epithelial ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1521

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12

Digitale Medien

Biomarkers trump behavior in mental illness diagnosis (2007)

Haag, Amanda Leigh

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 3-3

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Here's how doctors decide which mental or neurological disorder their troubled patients suffer from: they ask questions like, “Are you hearing voices?” and “Do you feel like people are out to get you?”... Not all that different from how they used to do it about 100 years ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0107-3

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13

Digitale Medien

A 'good death' for tumor immunology (2007)

Storkus, Walter J ; Falo, Louis D

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 28-30

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Findings by Obeid et al. in this issue highlight a way to potentially enhance the ability of the immune system to kill tumor cells. The authors suggest that how cells die during chemotherapy is critical; one set of chemotherapeutic agents in particular, anthracyclins, seem to foster a favorable ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0107-28

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14

Digitale Medien

Abrogation of nuclear receptors Nr4a3 andNr4a1 leads to development of acute myeloid leukemia (2007)

Mullican, Shannon E ; Zhang, Shuo ; Konopleva, Marina ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 730-735

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nur77 (NR4A1) and Nor-1 (NR4A3) are highly homologous orphan nuclear receptors that regulate the transcription of overlapping target genes. The transcriptional activity of both proteins is regulated in a ligand-independent manner by cell- and stimulus-specific gene induction and protein ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1579

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15

Digitale Medien

Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists (2007)

Buonpane, Rebecca A ; Churchill, Hywyn R O ; Moza, Beenu ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 725-729

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Exotoxins of Staphylococcus aureus belong to a family of bacterial proteins that act as superantigens by activating a large subset of the T-cell population, causing massive release of inflammatory cytokines. This cascade can ultimately result in toxic shock syndrome and death. Therapeutics ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1584

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16

Digitale Medien

T H 17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 (2007)

Amadi-Obi, Ahjoku ; Yu, Cheng-Rong ; Liu, Xuebin ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 711-718

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] T-helper type 17 cells (TH17) are implicated in rodent models of immune-mediated diseases. Here we report their involvement in human uveitis and scleritis, and validate our findings in experimental autoimmune uveoretinitis (EAU), a model of uveitis. TH17 cells were present in human peripheral blood ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1585

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17

Digitale Medien

Retinaldehyde represses adipogenesis and diet-induced obesity (2007)

Ziouzenkova, Ouliana ; Orasanu, Gabriela ; Sharlach, Molly ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 695-702

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The metabolism of vitamin A and the diverse effects of its metabolites are tightly controlled by distinct retinoid-generating enzymes, retinoid-binding proteins and retinoid-activated nuclear receptors. Retinoic acid regulates differentiation and metabolism by activating the retinoic acid receptor ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1587

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18

Digitale Medien

Dramatic rescue relieves rare case of smallpox infection (2007)

Marris, Emma

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 517-517

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Soldier's son, wife develop rare case of eczema ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0507-517

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19

Digitale Medien

News feature: Bugs vs Drugs (2007)

Braaten, Douglas

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 522-523

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In the ongoing battle between bacteria and antibiotics, strains of Staphylococcus aureus are emerging the winners, reports Douglas ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0507-522

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20

Digitale Medien

Straight talk from... Jim Young (2007)

Mandavilli, Apoorva

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 524-524

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] How good is the new prostate cancer ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0507-524

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21

Digitale Medien

News in brief (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 520-521

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] 19 Mar A group of nine prominent American scientific institutions call for an increase in funding for the US National Institutes of Health, warning that stagnant budgets outpaced by inflation threaten the progress of biomedical research.... 19 Mar Mosquitoes modified to carry a gene that ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0507-520

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22

Digitale Medien

The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells (2007)

Ohsugi, Takeo ; Kumasaka, Toshio ; Okada, Seiji ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 527-528

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor: Adult T-cell leukemia/lymphoma (ATLL) is a fatal T-cell neoplasm caused by infection with human T-cell leukemia virus type I (HTLV-I). Hasegawa et al. have described transgenic mice that express HTLV-I Tax viral regulatory protein/oncoprotein in thymocytes. These mice developed ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0507-527

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23

Digitale Medien

Autism: highly heritable but not inherited (2007)

Beaudet, Arthur L

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 534-536

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Until recently, only 5–10% of autism cases were traceable to an underlying genetic cause. Two studies now change this. Jacquemont et al. and Sebat et al. suggest that this number is actually 10–20%, and it may grow to 30–40% with further research. The advance is based primarily on ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0507-534

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24

Digitale Medien

A new way to regulate the NMJ (2007)

Davies, Kay E ; Khurana, Tejvir S

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 538-539

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] This year marks the twentieth anniversary of the discovery of the dystrophin gene, which is mutated in the devastating X-linked recessive muscle disease Duchenne muscular dystrophy (DMD). During DMD, heart and skeletal muscles break down, so that the affected boys are typically wheelchair-bound by ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0507-538

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25

Digitale Medien

The bridge between dendritic cells and asthma (2007)

Shinohara, Mari L ; Cantor, Harvey

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 536-538

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The key immunological regulator osteopontin was first identified as a structural protein in bone that formed a bridge (Latin pons) between the bone's mineral matrix and the bone cells inside it. Later, expression of osteopontin by activated T cells and dendritic cells was found to be an essential ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0507-536

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26

Digitale Medien

Eat your heart out (2007)

Kitsis, Richard N ; Peng, Chang-Fu ; Cuervo, Ana Maria

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 539-541

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Heart failure is a common and lethal condition, yet why the heart muscle fails remains a mystery. Alterations in myocardial metabolism, defects in calcium handling, alterations in myosin isoforms, cytoskeletal abnormalities and excessive cardiac myocyte apoptosis have all been implicated as causal ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0507-539

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27

Digitale Medien

MicroRNAs loom large in the heart (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 541-541

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] How microRNAs (miRNAs) influence heart development and disease is a topic of growing interest. miRNAs regulate gene expression post-transcriptionally, typically by binding to mRNAs and inhibiting their translation. Three recent papers show that miRNAs are essential for heart development and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0507-541

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28

Digitale Medien

Research highlights (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 542-542

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Gender matters How infertility-causing mutations are inherited is a tough puzzle. A dominant mutation with sex-specific phenotypes provides a clue (PLoS, doi:10.1371/journal.pbio.0050105). In screening mice for infertility, Laura Bannister et al. isolated a male sterile allele of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0507-542

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29

Digitale Medien

Derivation of engraftable skeletal myoblasts from human embryonic stem cells (2007)

Bradbury, Michelle ; Dincer, Zehra ; Panagiotakos, Georgia ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 642-648

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Human embryonic stem cells (hESCs) are a promising source for cell therapy in degenerative diseases. A key step in establishing the medical potential of hESCs is the development of techniques for the conversion of hESCs into tissue-restricted precursors suitable for transplantation. We recently ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1533

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30

Digitale Medien

Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells (2007)

Duncan, Mathew J ; Song, Jeongmin ; Li, Guojie ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 625-630

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The superficial bladder epithelium is a powerful barrier to urine and also serves as a regulator of bladder volume, which is achieved by apical exocytosis of specialized fusiform vesicles during distension of the bladder. We report that type 1 fimbriated uropathogenic Escherichia coli (UPEC) ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1572

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31

Digitale Medien

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes (2007)

Berdeaux, Rebecca ; Goebel, Naomi ; Banaszynski, Laura ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 597-603

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] During physical exercise, increases in motor neuron activity stimulate the expression of muscle-specific genes through the myocyte enhancer factor 2 (MEF2) family of transcription factors. Elevations in intracellular calcium increase MEF2 activity via the phosphorylation-dependent inactivation of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1573

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Controversy over cervical cancer vaccine spurs safety surveillance (2007)

Keim, Brandon

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 392-393

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] When Gardasil, the first vaccine against human papilloma virus (HPV), was approved in June 2006 by the US Food and Drug Administration, it was widely hailed as a godsend for women.... Clinical trials involving more than 20,000 women showed the vaccine to be safe and effective. But the vaccine's ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0407-392b

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Aggressive drug marketing tactics trigger backlash (2007)

Singer, Emily

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 393-393

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The average doctor's office these days looks much like a pharmaceutical sales convention: patients wipe their noses with Lipitor tissues and sign forms with Boniva pens attached to Lunesta clipboards. The ubiquity of these drug ads—and the sales representatives that place them—is ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0407-393

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Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance (2007)

Lesniewski, Lisa A ; Hosch, Sarah E ; Neels, Jaap G ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 455-462

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Cbl-associated protein (Cap) is a member of a phosphatidylinositol 3-kinase–independent pathway for insulin-stimulated translocation of the glucose transporter GLUT4. Despite this positive role of Cap in glucose uptake, here we show that deletion of the gene encoding Cap (official gene name: ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1550

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Angiogenic inhibition reduces germinal matrix hemorrhage (2007)

Xu, Hongmin ; Hu, Furong ; Braun, Alex ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 477-485

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The germinal matrix of premature infants is selectively vulnerable to hemorrhage within the first 48 h of life. To assess the role of vascular immaturity in germinal matrix hemorrhage (GMH), we evaluated germinal matrix angiogenesis in human fetuses and premature infants, as well as in premature ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1558

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News in brief (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 234-235

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] 22 Jan Hoping to raise flagging employee morale, the US Centers for Disease Control and Prevention will hire a full-time ombudsman, agency director Julie Gerberding announces. 24 Jan The first draft of the human 'metabolome' describes more than 2,500 metabolites found in the body, of which fewer ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-234

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Plagues and people meet the microbe hunters (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 239-239

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In the history many of us are taught, the fates of societies are determined almost exclusively by the acts of humans, and then primarily humans bearing at least one Y chromosome. In The Power of Plagues, Irwin Sherman challenges this perspective. In the tradition of the Hans Zinsser's 1935 Rats, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-239

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Langerhans cells lap up HIV-1 (2007)

Schwartz, Olivier

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 245-246

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Paul Langerhans, a German medical student, was 21 when he described in 1868 a new epidermal cell type which now bears his name. The cells have long dendrites, so Langerhans regarded them as a component of the nervous system. A century later, Inga Silberberg discovered that these cells instead have ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-245

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Cracking the cytokine code in psoriasis (2007)

Nickoloff, Brian J

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 242-244

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Recent research has led to a shift in thinking about the pathology of Crohn disease, in which chronic inflammation damages the gastrointestinal track. This paradigm shift highlights a key role for the interleukin (IL)-23 cytokine, rather than the previous emphasis on IL-12, as the driving force ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-242

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Long-distance affair with adrenal GRK2 hangs up heart failure (2007)

Liggett, Stephen B

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 246-248

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] G protein–coupled receptors (GPCRs) are the largest superfamily of receptors in the human genome. These cell surface receptors transduce signals of an amazing diversity: vision, smell, central and peripheral neurotransmission, and a host of hormone, autocrine and paracrine actions regulating ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-246

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Vaccine leads to memory loss (2007)

Haanen, John B A G ; Schumacher, Ton N M

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 248-250

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Can a vaccine be 'too efficient'? Can it provide such a strong stimulus to the immune system that the response is ultimately abortive rather than productive? In this issue, Berner et al. use mouse models to show that a widely heralded approach to vaccine adjuvants, targeting of the CD40 receptor, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-248

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Regulatory T-cell development: is Foxp3 the decider? (2007)

Curiel, Tyler J

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 250-253

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Tregs play essential roles in immune homeostasis and protection against autoimmunity, but also contribute to immunopathology in cancers, infections and other diseases. The recent discovery that the nuclear transcription factor forkhead box P3 (Foxp3) appeared necessary and sufficient for Treg ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-250

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A plague upon fibrin (2007)

Titball, Richard W ; Oyston, Petra C F

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 253-254

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Pneumonic plague is one of the most feared infectious diseases, but it is only recently that progress has been made in understanding the molecular interplay between pathogen and host during the disease. A recent study by Lathem et al. in Science shows that plasminogen activator (Pla), a surface ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-253

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Health agency pulls back on 'patronizing' approach to TB treatment (2007)

Mandavilli, Apoorva

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 269-269

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] For more than a decade, the World Health Organization (WHO) has relied on Direct Observed Therapy Short-course, or DOTS, to fight tuberculosis (TB)—and for nearly as long, the strategy has been controversial.... The idea behind DOTS is that a healthcare worker should directly observe those ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-269

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Spotlight on... Mark Harrington (2007)

Opar, Alisa

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 270-270

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] For a liberal arts graduate with no formal science background, Mark Harrington has a lot of influence on research for AIDS and tuberculosis (TB).... The head of the New York–based activist organization Treatment Action Group (TAG), Harrington commands respect from even the most senior AIDS ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-270

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Spotlight on... Ken Duncan (2007)

Opar, Alisa

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 271-271

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Ken Duncan began the year with a new job to fight an old foe.... In January, he became a senior program officer for the Bill & Melinda Gates Foundation's tuberculosis (TB) program, where his job will be to shepherd the development of new drugs for the disease. Duncan's main goal is to help ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-271b

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Virtually incurable TB warns of impending disaster (2007)

Mandavilli, Apoorva

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 271-271

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Like something out of a horror movie, a lethal strain of tuberculosis blazed in 2005 across Tugela Ferry, a small village in South Africa, striking down nearly everyone it touched.... The strain, dubbed XDR for extensively drug-resistant, doesn't respond to known TB drugs and killed 52 of 53 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-271a

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A dozen vaccine candidates bring shot of hope to TB epidemic (2007)

Marris, Emma

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 274-274

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The best hope of eradicating tuberculosis (TB) is to prevent it with mass vaccination. Trouble is, those vaccines don't exist—at least, not yet. The World Health Organization (WHO) has set a goal for a new vaccine by 2015. That may be a bit ambitious: scientists are still trying to pin down ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-274a

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Profile: Wafaa El-Sadr (2007)

Mandavilli, Apoorva

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 275-275

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In January, Médecins Sans Frontières hosted a two-day symposium in New York on tuberculosis (TB). The speakers were much like those at most scientific meetings—a long list of men, most of them from the US or Europe, speaking in lofty terms about big-picture goals.... Then came ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-275

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The top twenty papers on tuberculosis (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 276-277

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Which papers have provided the most interesting recent advances in tuberculosis research? Which new discoveries in pathogenesis, epidemiology, drug discovery or vaccine development have been the most important or are likely to have the highest impact to the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-276

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The open book of infectious diseases (2007)

Sassetti, Christopher M ; Rubin, Eric J

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 279-280

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Poor William Stewart. This former US Surgeon General is unfairly credited with stating in 1967 that it was “time to close the book on infectious disease.” Although it appears that he never said such a thing, the sentiment was certainly widely shared. For the past several decades, while ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-279

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Highly cited papers on tuberculosis (2003–2005) (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 278-278

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The following tables show the primary research papers on tuberculosis published between 2003 and 2005 that have had the highest number of citations in the literature. To create these tables, we queried the Scopus database (http://www.scopus.com) to search for articles that included the term ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-278

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Defining the 'survivasome' of Mycobacterium tuberculosis (2007)

Lamichhane, Gyanu ; Bishai, William

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 280-282

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The worldwide mortality and morbidity due to tuberculosis remains excessive despite the availability of drugs that can stably cure it. Multiple factors underlie this paradox. One is treatment duration: regimens of multiple drugs that need to be taken for at least six months without interruption ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-280

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The survival kit of Mycobacterium tuberculosis (2007)

Warner, Digby F ; Mizrahi, Valerie

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 282-284

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Macrophages are phagocytes at the frontline of host immune defense against microbial pathogens. They are also the primary habitat of Mycobacterium tuberculosis: unlike bacteria that dependent on the avoidance of phagocytosis to survive, M. tuberculosis preferentially targets macrophage vacuoles. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-282

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Research highlights (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 288-289

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Meet the family From an evolutionary perspective, Mycobacterium tuberculosis and its close relatives are so similar that they seem to have separated from a common ancestor only 20,000–35,000 years ago. What happened before this separation? A 2005 paper by Cristina Gutierrez et al. has ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-288

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Mycobacterium tuberculosis virulence: lipids inside and out (2007)

Ehrt, Sabine ; Schnappinger, Dirk

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 284-285

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Lipids have long been thought to play key roles in the pathogenesis of Mycobacterium tuberculosis. In early studies, Segal and Bloch found fatty acids rather than carbohydrates to stimulate respiration of M. tuberculosis if the bacteria were isolated from mouse lungs instead of liquid cultures. In ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-284

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Mycobacterial virulence and specialized secretion: same story, different ending (2007)

Behr, Marcel A ; Sherman, David R

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 286-287

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Since its introduction as a public health intervention in 1921, vaccination with Bacillus Calmette-Guérin (BCG) has a long and controversial history. As a tool to study the pathogenesis of tuberculosis, BCG has a much shorter, but no less interesting, history. Despite its excellent safety ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-286

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Challenges in tuberculosis drug research and development (2007)

Ginsberg, Ann M ; Spigelman, Melvin

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 290-294

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The present decade has seen a reawakening of tuberculosis (TB) drug research and development (R&D), spurred on by an urgent need to stem the tide of the disease globally and develop new, more effective treatments against drug-sensitive and resistant strains. As a result, there are now seven ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-290

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From magic bullets back to the Magic Mountain: the rise of extensively drug-resistant tuberculosis (2007)

Dorman, Susan E ; Chaisson, Richard E

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 295-298

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Extensively drug-resistant tuberculosis (XDR-TB) occurs where health systems have been historically weak; it lays bare the reality of TB as a serious public health problem, especially in areas of high HIV prevalence, and reinforces the need for effective TB control strategies that are coordinated ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-295

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Changing funding patterns in tuberculosis (2007)

Kaufmann, Stefan H E ; Parida, Shreemanta K

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 299-303

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Exactly 125 years after the discovery of the etiological agent of tuberculosis (TB), the disease remains as threatening as ever. The insufficient control measures in place today were developed in the late nineteenth and early twentieth centuries. A research and development gap in the latter half of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-299

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Aligning pharmaceutical innovation with medical need (2007)

Nathan, Carl

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 304-308

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] How can we make vaccines and medicines for major diseases that have been largely ignored? How can we get vaccines and medicines to populations that cannot afford them? A fundamental solution to these problems requires aligning three basic processes—innovation, incentive and access—so ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-304

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Erratum: A brief history of T H 17, the first major revision in the T H 1/T H 2 hypothesis of T cell–mediated tissue damage (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 385-385

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nature Med. 13, 139–145 (2007); published online 6 February 2007; corrected after print 21 February 2007. In the version of this article initially published, the labeling in Figure 1 is incorrect. Tregs should be shown as producing TGF-β, not IL-17. The error has been corrected in the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-385a

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Corrigendum: Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 385-385

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nature Medicine 12, 1259–1268 (2006); published online 22 October 2006. In page 1264 of this article, it is stated that “The donor cells were dispersed over an average radius of 1.6 ± 0.6 mm, and the mean number of HNA+ nuclei/mm3 within each was 136,726 ± 23,515”. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-385b

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Digitale Medien

Tuberculosis, a neglected opportunity? (2007)

Harper, Claire

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 309-312

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Historically, tuberculosis (TB) has fallen firmly in the group of 'neglected diseases'—diseases in which pharmaceutical companies have been reluctant to invest due to a perception of low commercial potential. According to the World Health Organization (WHO), an estimated 1.7 million deaths ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0307-309

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In vivo imaging of siRNA delivery and silencing in tumors (2007)

Medarova, Zdravka ; Pham, Wellington ; Farrar, Christian ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 372-377

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] With the increased potential of RNA interference (RNAi) as a therapeutic strategy, new noninvasive methods for detection of siRNA delivery and silencing are urgently needed. Here we describe the development of dual-purpose probes for in vivo transfer of siRNA and the simultaneous imaging of its ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1486

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Digitale Medien

Humanization of autoantigen (2007)

Nishie, Wataru ; Sawamura, Daisuke ; Goto, Maki ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 378-383

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Transmissibility of characteristic lesions to experimental animals may help us understand the pathomechanism of human autoimmune disease. Here we show that human autoimmune disease can be reproduced using genetically engineered model mice. Bullous pemphigoid (BP) is the most common serious ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1496

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Langerin is a natural barrier to HIV-1 transmission by Langerhans cells (2007)

de Witte, Lot ; Nabatov, Alexey ; Pion, Marjorie ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 367-371

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Human immunodeficiency virus-1 (HIV-1) is primarily transmitted sexually. Dendritic cells (DCs) in the subepithelium transmit HIV-1 to T cells through the C-type lectin DC-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin (DC-SIGN). However, the epithelial Langerhans cells ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1541

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ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor (2007)

Yang, Zhiming ; Chang, Yu-Jia ; Yu, I-Chen ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 348-353

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Motor neuron degeneration resulting from the aggregation of the androgen receptor with an expanded polyglutamine tract (AR-polyQ) has been linked to the development of spinal and bulbar muscular atrophy (SBMA or Kennedy disease). Here we report that adding ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1547

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β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment (2007)

Brunham, Liam R ; Kruit, Janine K ; Pape, Terry D ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 340-347

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Type 2 diabetes is characterized by both peripheral insulin resistance and reduced insulin secretion by β-cells. The reasons for β-cell dysfunction in this disease are incompletely understood but may include the accumulation of toxic lipids within this cell type. We examined the role of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1546

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Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure (2007)

Lymperopoulos, Anastasios ; Rengo, Giuseppe ; Funakoshi, Hajime ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 315-323

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Cardiac overstimulation by the sympathetic nervous system (SNS) is a salient characteristic of heart failure, reflected by elevated circulating levels of catecholamines. The success of β-adrenergic receptor (βAR) antagonists in heart failure argues for SNS hyperactivity being pathogenic; ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1553

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Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3β activity (2007)

Trivedi, Chinmay M ; Luo, Yang ; Yin, Zhan ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 324-331

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In the adult heart, a variety of stresses induce re-expression of a fetal gene program in association with myocyte hypertrophy and heart failure. Here we show that histone deacetylase-2 (Hdac2) regulates expression of many fetal cardiac isoforms. Hdac2 deficiency or chemical histone deacetylase ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1552

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IFN-γ mediates CD4 + T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy (2007)

Berner, Vanessa ; Liu, Haiyan ; Zhou, Qing ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 354-360

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Protective cell-mediated immune responses in cancer are critically dependent on T-helper type 1 (TH1) cytokines such as interferon-γ (IFN-γ). We have previously shown that the combination of CD40 stimulation and interleukin-2 (IL-2) leads to synergistic antitumor responses in several ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1554

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Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer (2007)

Beane, Jennifer E ; Shah, Vishal ; Steiling, Katrina ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 361-366

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Lung cancer is the leading cause of death from cancer in the US and the world. The high mortality rate (80–85% within 5 years) results, in part, from a lack of effective tools to diagnose the disease at an early stage. Given that cigarette smoke creates a field of injury throughout the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1556

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Safeguarding clinical trials (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 107-107

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Conducting clinical trials has never been easy, but when testing a new drug or therapy can risk lives, it stands to reason that the public should demand strict oversight. Yet the public is equally impatient for better disease treatments, and increased regulation has the potential to slow the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-107

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Reformed US malaria program garners critics' approval (2007)

Schubert, Charlotte

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 109-109

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] It's been almost two years since the US Congress, spurred by reports that the country's malaria aid programs were hemorrhaging money, took the responsible agency to task for poor accounting and outsize payments to consultants.... The administration seems to have got the message. US malaria ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-109a

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Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions (2007)

Yamauchi, Toshimasa ; Nio, Yasunori ; Maki, Toshiyuki ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 332-339

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Adiponectin plays a central role as an antidiabetic and antiatherogenic adipokine. AdipoR1 and AdipoR2 serve as receptors for adiponectin in vitro, and their reduction in obesity seems to be correlated with reduced adiponectin sensitivity. Here we show that adenovirus-mediated expression of AdipoR1 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1557

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Tied up in red tape, European trials shut down (2007)

Keim, Brandon

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 110-110

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The chemotherapy drug doxorubicin has been used to treat soft-tissue cancers in children for more than 20 years, but doctors don't know the most effective dose, nor how it interacts with other drugs. In 2005, European researchers set out to find these answers in a large, multi-center trial. Two ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-110a

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Supplement makers face bitter pill (2007)

Wadman, Meredith

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 109-109

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The last time US Democrats controlled Congress, in 1994, dietary supplement makers received a huge windfall: a new law that gave them the right to make unproven health claims about their products. This time around, things don't look quite so rosy for the industry, which has grown from a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-109b

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Ambitious scheme for developing world trials in 'big trouble' (2007)

Keim, Brandon

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 110-110

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] When the European and Developing Countries Clinical Trials Programme (EDCTP) was formed in 2003, some public health experts worried that the pan-European scheme would conflict with national research programs. Others wondered whether its emphasis on AIDS, malaria and tuberculosis would cause other ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-110b

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Australia set to test insulin 'vaccine' for juvenile diabetes (2007)

Grose, Simon

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 111-111

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A 'vaccine-like' approach to juvenile diabetes, set to be tested in a clinical trial in Australia, aims to test whether delivering insulin through the nose can keep the immune system from attacking the body's own cells. Vaccines prime the immune system to attack invaders and protect the body. But ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-111a

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US proposal to expand access to untested drugs draws fire (2007)

Waltz, Emily

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 111-111

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Should those who are sick or dying and have exhausted all other options be able to try drugs that haven't yet been approved? The US Food and Drug Administration (FDA) seems to think so and in December proposed a controversial scheme to help people get the drugs they need. The move could cause ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-111b

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Biomass fuels blamed for premature deaths in rural settings (2007)

Padma, T.V.

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 112-112

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Pollution is seen mostly as an urban problem, with mega cities spewing soot and fumes into the air. Twigs, leaves, dung and the countryside hardly fit that picture.... In millions of homes across rural Asia, Africa and Latin America, however, indoor air pollution caused by burning biomass and coal ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-112a

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British scientists find patent loophole (2007)

Keim, Brandon

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 112-112

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Two British researchers say they have found a way to produce low-cost versions of expensive pharmaceuticals without breaking patent laws. Sunil Shaunak and Steve Brocchini call their products “ethical pharmaceuticals.” Their first target is a naturally occurring molecule called ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-112b

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Vikram Kumar (2007)

Keim, Brandon

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 113-113

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In rural Zambia, people are often on the move, changing homes, schools and clinics with every move. Their medical records are rarely, if ever, maintained by hospitals.... But since last year, 60,000 HIV-positive Zambians in Lusaka district have carried their entire medical histories on plastic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-113

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News in brief (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 114-115

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] 16 Dec Women who receive high doses of hormones for in vitro fertilization are more likely to produce genetically damaged embryos, UK researchers report. 21 Dec A specialized PET scan can detect deposits of amyloid and tau proteins, associated with Alzheimer disease, before symptoms emerge, US ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-114

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Gut warfare (2007)

Check, Erika

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 116-117

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] HIV is supposed to be a slow and stealthy killer. For years, scientists have thought the virus begins its assault in the blood, destroying just a few of its favorite targets—specialized immune cells called CD4 T-helper cells, which anchor the body's defenses against infections.... After that ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-116

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Large stem cell grafts could lead to erroneous interpretations of behavioral results? (2007)

Christophersen, Nicolaj Strøyer ; Brundin, Patrik

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 118-118

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor: The recent paper by Roy et al. presents highly interesting results that could represent a major advance in the area of stem cell–based brain repair. The results also illustrate that it can be difficult to evaluate functional effects of stem cell–derived transplants to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-118a

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Large stem cell grafts could lead to erroneous interpretations of behavioral results? (2007)

Goldman, Steven A ; Roy, Neeta S ; Beal, M Flint ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 118-119

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Roy et al. reply: We thank Christophersen and Brundin for their comments. They expressed two principal concerns: that our behavioral results might not have unequivocally established graft-dependent functional recovery and that our graft volumes might have been excessive relative to the striatal ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-118b

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Where is the problem in the Ramón y Cajal program? (2007)

Sanz-Menéndez, Luis

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 119-120

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor: Your report on Spain's Ramón y Cajal program (RyC) states that part of the problem with this initiative is that “the government launched an ambitious scheme without consulting with the universities.” This is incorrect; universities were involved in the promotion, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-119

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ACE inhibitor bulks up muscle (2007)

Chamberlain, Jeffrey S

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 125-126

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Because of its outstanding regenerative capabilities, skeletal muscle recovers readily from a variety of acute and chronic injuries. But what happens in a serious disorder in which the disease process impairs muscle regeneration? In this issue of Nature Medicine, Cohn et al. examine this question. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-125

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Orexins: looking forward to sleep, back at addiction (2007)

Scammell, Thomas E ; Saper, Clifford B

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 126-128

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Roman god Janus displays two faces, one looking back and the other toward what lies ahead. Like Janus, we can look back over the last several years and appreciate how much we have learned about the roles of the orexin neuropeptides in the regulation of wakefulness and sleep, the control of body ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-126

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92

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Receptor feasts on sugar and cholesterol (2007)

Rodgers, Joseph T ; Puigserver, Pere

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 128-129

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The essence of energy homeostasis is the ability to sense the amounts of circulating nutrients and to adjust metabolic pathways in order to maintain tightly controlled nutrient levels. A vast array of hormones and nutrients impinge on metabolic networks, with the end result being homeostasis. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-128

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93

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The past, present and future of neural prosthetics (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 123-123

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Shattered Nerves by Victor Chase is a comprehensive and easily readable survey of the field of neural prosthetics—devices that interact with the nervous system to restore or replace lost neural function. I was impressed by the book's level-headed and unbiased coverage of the successes and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-123

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94

Digitale Medien

Seeing what Alzheimer saw (2007)

de Leon, Mony J ; Mosconi, Lisa ; Logan, Jean

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 129-131

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Since Alois Alzheimer's seminal report in November of 1906, pathologists have regarded amyloid-β deposits in senile plaques and neurofibrillary tangles as essential for the diagnosis of Alzheimer disease. In the past 30 years, progress has been made in developing biomarkers to bridge the gap ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-129

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95

Digitale Medien

A prize catch for diabetic retinopathy (2007)

Gardner, Thomas W ; Antonetti, David A

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 131-132

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Many disease mechanisms are identified by testing candidate mediators based on educated guesses. This approach is inherently limiting and fails to allow for discovery of completely novel aspects of a disease process. In this issue, Gao et al. use an unbiased proteomics approach to identify a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-131

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96

Digitale Medien

Research highlights (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 136-137

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Mice are us A new technical advance should accelerate research into mouse models of human disease. Helen Wallace et al. have 'humanized' mice by developing a technique to insert large segments of human DNA—greater than 100 kb—in place of the endogenous mouse DNA (Cell 128, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-136

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97

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Eating bone or adding it: the Wnt pathway decides (2007)

Goldring, Steven R ; Goldring, Mary B

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 133-134

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Joint pain comes in many flavors. When it comes to arthritis, however, there is at least one major difference among the various types. In inflammatory conditions such as rheumatoid arthritis, bone destruction kicks into overdrive and there is a shutdown of bone repair. In contrast, in conditions ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-133

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98

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Corrigendum: In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' (2007)

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 224-224

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nature Medicine 13, 13–14 (2007); corrected after print 25 January 2007 , the corresponding author's last name was stated as Gambacorti, but should have been Gambacorti-Passerini. The error has been corrected in the HTML and PDF versions of the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0207-224

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99

Digitale Medien

Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection (2007)

Tsui, Nancy B Y ; Chiu, Rossa W K ; Lau, Tze K ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 218-223

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Current methods for prenatal diagnosis of chromosomal aneuploidies involve the invasive sampling of fetal materials using procedures such as amniocentesis or chorionic villus sampling and constitute a finite risk to the fetus. Here, we outline a strategy for fetal chromosome dosage assessment that ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1530

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100

Digitale Medien

Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein (2007)

O'Connor, Kevin C ; McLaughlin, Katherine A ; De Jager, Philip L ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 211-217

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The role of autoantibodies in the pathogenesis of multiple sclerosis (MS) and other demyelinating diseases is controversial, in part because widely used western blotting and ELISA methods either do not permit the detection of conformation-sensitive antibodies or do not distinguish them from ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1488

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