ISSN:
1432-1017
Keywords:
tRNA cycle
;
optimization
;
elongation rate
;
codon frequency
;
tRNA synthetase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Physics
Notes:
Abstract With the aid of a kinetic model, we have investigated how the adaptation between the various components of the tRNA cycle and the codon frequencies affects the rate of protein synthesis. Depending on the relative amounts of total tRNA, synthetase and ribosomes, the optimal correlations vary between a situation where all tRNA species are either present in equal amounts or are present in amounts proportional to the square-root of the corresponding codon frequencies, and a situation where the amounts of the different tRNA species present are linearly proportional to the codon frequencies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00260434
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