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  • Articles  (46)
  • Articles: DFG German National Licenses  (46)
  • Latest Papers from Table of Contents or Articles in Press
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  • Springer  (46)
  • American Chemical Society (ACS)
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  • 2020-2024
  • 2015-2019
  • 1985-1989  (42)
  • 1980-1984
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  • 1987  (25)
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  • Medicine  (46)
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  • Articles  (46)
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  • Articles: DFG German National Licenses  (46)
  • Latest Papers from Table of Contents or Articles in Press
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  • Springer  (46)
  • American Chemical Society (ACS)
  • American Society of Hematology
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  • 2020-2024
  • 2015-2019
  • 1985-1989  (42)
  • 1980-1984
  • 1970-1974  (4)
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  • 1
    Electronic Resource
    Electronic Resource
    Mechanism of interaction of tolbutamide and phenylbutazone in diabetic patients (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 291-294 
    Details
    ISSN: 1432-1041
    Keywords: Tolbutamide ; phenylbutazone ; diabetes ; drug interaction ; phenylbutazone metabolites ; tolbutamide metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Four hospitalized women with adult onset diabetes mellitus received the following treatments for periods of three days: diet alone (D), 1000 mg tolbutamide daily (T), 600 mg phenylbutazone daily (P), and 1000 mg tolbutamide plus 600 mg phenylbutazone daily (P+T). The serum level of phenylbutazone rose during P-period and changed little during the following P+T period. The plasma levels of phenylbutazone metabolites and urinary excretion of phenylbutazone and its metabolites showed similar changes. During the T-period the serum level of tolbutamide fell almost to zero at some time each day. During the T+P-period there was accumulation of tolbutamide. In contrast, urinary tolbutamide and carboxytolbutamide excretion during the T+P-period were significantly lower than in the T-period. The results suggest that the interaction of tolbutamide and phenylbutazone is mainly due to inhibition of excretion of tolbutamide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00560347
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of oral ferrous sulphate on the half-life of doxycycline in man (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 361-363 
    Details
    ISSN: 1432-1041
    Keywords: Iron ; doxycycline ; drug interaction ; enterohepatic circulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double-blind cross-over study in seven patients, oral ferrous sulphate (80 mg Fe++) given 3, 7 and 11 h after a daily oral dose of doxycycline, lowered the serum concentration of doxycycline by 20–45%. The half-life of intravenous doxycycline was shortened from 16.6±0.7 h to 11.0±0.4 h by concomitant oral iron therapy. These results are an indirect indication of significant intestinal secretion and reabsorption of doxycycline. The interaction between doxycycline and iron cannot be avoided completely by leaving an interval of 3 h between doses of the two drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558207
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  • 3
    Electronic Resource
    Electronic Resource
    Plasma levels of lidocaine during combined treatment with phenytoin and procainamide (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 455-459 
    Details
    ISSN: 1432-1041
    Keywords: Lidocaine ; phenytoin ; procainamide ; plasma concentration ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of phenytoin and procainamide on plasma concentrations of lidocaine have been studied in patients and dogs receiving continuous intravenous infusions of the latter drug. All drugs were given in doses that produced therapeutic plasma concentrations. In the patients, no changes were observed in plasma lidocaine levels after intravenous or intramuscular phenytoin, or after intravenous or oral procainamide. Similarly, in the dogs, intravenous phenytoin had no effect on plasma lidocaine concentrations. However, in both patients and dogs a high incidence of CNS side-effects was recorded during lidocaine — phenytoin combination therapy, which suggests a potential pharmacodynamic interaction between them. The absorption of phenytoin administered intra-muscularly was impaired, probably because of pH-dependent crystallization. This route of administration should be avoided in acute treatment with phenytoin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00560358
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of josamycin on plasma cyclosporine levels (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 327-328 
    Details
    ISSN: 1432-1041
    Keywords: josamycin ; cyclosporine ; drug interaction ; case reports
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607585
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  • 5
    Electronic Resource
    Electronic Resource
    Comparative pharmacokinetics of theophylline following two fluoroquinolones co-administration (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 431-432 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; fluoroquinolones ; drug interaction ; pharmacokinetics ; ofloxacin ; norfloxacin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Pretreatment for 3 days with oral ofloxacin or norfloxacin had no significant effect on the disposition of a single i.v. dose the theophylline in healthy volunteers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543982
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  • 6
    Electronic Resource
    Electronic Resource
    Enoxacin — a potent inhibitor of theophylline metabolism (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 227-230 
    Details
    ISSN: 1432-1041
    Keywords: enoxacin ; theophylline ; drug interaction ; healthy volunteers ; adverse effects ; pharmacokinetics ; renal tubular excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The mechanism of the theophylline-enoxacin interaction has been studied in six healthy subjects. Theophylline 250 mg was administered p.o., twice daily for 11 days in a sustained release dosage form. On the 4th day of treatment, blood samples were taken every 2 h and urine was collected over 1 dose interval. From Days 5 to 11 coated tablets of enoxacin 400 mg b.i.d. were coadministered. On Day 11 blood and urine were collected as on Day 4. The mean plasma theophylline concentration rose from 4.4 to 15.1 mg/l, corresponding to a 73.6% reduction in total clearance. The urinary excretion of unchanged theophylline increased from 12.7 to 35.3%, whereas the production of metabolites was reduced (1-demethylation 81.4%; 3-demethylation 83.1%, 8-hydroxylation 74.6%). The results indicate that the theophylline-enoxacin interaction may be due to inhibition of the cytochrome P-450 isozymes responsible for theophylline metabolism. Unexpectedly, the renal clearance of theophylline metabolites was found to be drastically reduced when enoxacin was coadministered. This led to unchanged or even to elevated plasma levels of the metabolites. The mechanism of this interaction is still to be elucidated, but it may be due to competition for renal tubular secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637553
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  • 7
    Electronic Resource
    Electronic Resource
    Absence of a clinically significant interaction between theophylline and furosemide (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 487-491 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; furosemide ; drug interaction ; urinary flow ; renal clearance ; urinary excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In new of previous contradictory results, the possible interaction between the loop diuretic furosemide and theophylline was re-evaluated in 12 healthy volunteers with a steady-state plasma theophylline level. Two doses of furosemide 20 mg at a 4 h interval did not influence the steady-state plasma concentration of theophylline despite causing a moderate diuresis. Urinary recovery of theophylline and its metabolites amounted to 106±21% of the dose without furosemide and 96±19% of the dose with furosemide, demonstrating that there was no influence on the enteral absorption of theophylline of the furosemide treatment. After the first dose of furosemide the fractional renal clearance (CLR1) of theophylline (fractional = hourly sampling period) changed in parallel with the urinary flow rate, without a significant difference between treatment with and without furosemide. After the second dose of furosemide, CLR1 was increased in the first hour and then it declined to levels far lower than the control value. This unexpected result could explain the unchanged plasma concentration of theophylline during furosemide treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544241
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  • 8
    Electronic Resource
    Electronic Resource
    Troleandomycin-triazolam interaction in healthy volunteers: Pharmacokinetic and psychometric evaluation (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 389-393 
    Details
    ISSN: 1432-1041
    Keywords: triazolam ; troleandomycin ; benzodiazepines ; antibiotics ; drug interaction ; pharmacokinetics ; first-pass effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Seven healthy volunteers received a single oral dose of triazolam 0.25 mg after 7 days on troleandomycin 2 g/day p.o. or placebo in a double-blind cross-over study. Plasma triazolam and psychometric and memory tests (including Critical Flicker Fusion threshold, Choice Reaction Time, Digit Symbol Substitution and Self-Rating Scales) were assessed at regular intervals after the final treatment. Troleandomycin was found to prolong the psychomotor impairment and amnesia produced by triazolam. There was a significant enhancement of the AUC, the peak concentration and the delay to tmax of triazolam after 7 days treatment with troleandomycin compared to placebo. Thus, there is a pharmacokinetic interaction, and the combination of triazolam and troleandomycin should be avoided or the dose of triazolam should be adjusted. The most likely mechanism is a diminished hepatic first-pass effect, and a decrease in the apparent oral clearance of triazolam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543975
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  • 9
    Electronic Resource
    Electronic Resource
    Femoxetine and cimetidine: Interaction in healthy volunteers (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 299-302 
    Details
    ISSN: 1432-1041
    Keywords: femoxetine ; cimetidine ; pharmacokinetics ; drug interaction ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The possibility of a pharmacokinetic interaction between femoxetine and cimetidine has been evaluated in 8 healthy volunteers. Two volunteers received single doses of femoxetine, and 6 were given multiple doses of femoxetine for 7 days with and without concurrent cimetidine. No influence of cimetidine was observed on the kinetics of single doses of femoxetine, but after multiple doses the plasma concentration of femoxetine was significantly increased. Similarly, the AUC at steady state tended to be increased, but not to a significant extent. Concurrent cimetidine did not cause a reduction in the AUC of the active desmethyl metabolite. It is recommended that femoxetine is given in reduced doses (e.g. 400 mg) when administered with cimetidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00981127
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  • 10
    Electronic Resource
    Electronic Resource
    Influence of slow calcium-channel blockade on the cardiovascular effects of coffee (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 171-175 
    Details
    ISSN: 1432-1041
    Keywords: caffeine ; verapamil ; coffee ; blood pressure ; slow calcium-channel blockade ; drug interaction ; healthy volunteers ; plasma catecholamines ; plasma renin activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary An increase in blood pressure after coffee and caffeine has recently been reported. A possible pharmacological mechanism for this pressor response is a rise in the intracellular calcium concentration, caused by an increase in calcium influx due to a direct effect of caffeine. Accordingly, the cardiovascular effects of drinking coffee after placebo and verapamil 3 × 80 mg in 1 day in 10 normotensive volunteers have been examined in a single-blind study. After placebo, coffee led to an increase in blood pressure (7/14 mm Hg), and a fall in heart rate (−7 beats/min); forearm blood flow did not change. Plasma epinephrine rose (257%), plasma norepinephrine did not change and the plasma renin activity fell significantly. The haemodynamic and humoral changes after coffee were not altered by pretreatment with verapamil. It is concluded that increased transmembrane calcium influx after caffeine does not appear to be an important pharmacological mechanism for the circulatory effects of coffee.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614297
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