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  • Books  (9)
  • E-Books: Biomedical and Life Sciences (AWI only)  (9)
  • Biomedical Research.  (9)
  • 612.8  (6)
  • 616.9041  (3)
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  • Books  (9)
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  • E-Books: Biomedical and Life Sciences (AWI only)  (9)
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  • 1
    Online Resource
    Online Resource
    Neural Circuits of Innate Behaviors (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Neurosciences. ; Medicine Research. ; Biology Research. ; Psychology. ; Neuroscience. ; Biomedical Research. ; Behavioral Sciences and Psychology.
    Description / Table of Contents: Chapter 1: Neural Circuits Underlying Innate Fear -- Chapter 2: Neurobiology and Neural Circuits of Aggression -- Chapter 3: Neural Regulation of Feeding Behavior -- Chapter 4: Neural Circuits for Reward -- Chapter 5: Neuronal response and behavioral modulation in social interaction -- Chapter 6: Neural circuit mechanisms that underlie parental care -- Chapter 7: Spatial navigation -- Chapter 8: Neural circuits for sleep-wake regulation.
    Abstract: This book summarizes the latest research findings in the neurocircuitry of innate behaviors, covering major topics such as innate fear, aggression, feeding, reward, social interaction, parental care, spatial navigation, and sleep-wake regulation. For decades, humans have been fascinated by wild animals’ instincts, like the annual two-thousand-mile migration of the monarch butterfly in North American, and the “imprint” behavior of newborn birds. Since these instincts are always displayed in stereotypical patterns in most individuals of a given species, the neural circuits processing such behaviors must be genetically hard-wired in the brain. Recently, with the development of modern techniques, including optogenetics, retrograde and anterograde virus tracing, and in vivo calcium imaging, researchers have been able to determine and dissect the specific neural circuits for many innate behaviors by selectively manipulating well-defined cell types in the brain. This book discusses recent advances in the investigation of the neural-circuit mechanisms underlying innate behaviors.
    Type of Medium: Online Resource
    Pages: IX, 112 p. 13 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811570865
    Series Statement: Advances in Experimental Medicine and Biology, 1284
    URL: https://doi.org/10.1007/978-981-15-7086-5
    DOI: 10.1007/978-981-15-7086-5
    DDC: 612.8
    Language: English
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  • 2
    Online Resource
    Online Resource
    Biochemistry of Drug Resistance (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical microbiology. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Biotechnology. ; Medical Microbiology. ; Biomedical Research. ; Pharmacology. ; Biomedical Research. ; Biotechnology.
    Description / Table of Contents: 1.Introduction to Drugs, Drug Targets and Drug Resistance -- 2.Drugs Resistance in Bacterial Diseases -- 3.Drugs Resistance Against Viral Diseases -- 4.Drug Resistance in Protozoal Infections -- 5.Antifungal Drugs: Mechanism of Action and Resistance -- 6.Drug Resistance in Ear, Nose, and Throat Infections -- 7.Drug Resistance in Skin Diseases -- 8.Drugs Resistance in Lungs Diseases -- 9.Neurological Disorders: Biochemistry of Drug Resistance and Future Challenges -- 10.Drug Resistance in Kidney Diseases -- 11.Drugs resistance in Heart Diseases -- 12.Drugs Resistance in Liver Disease -- 13.Drug Resistance in Cancer -- 14.Drugs Resistance and Treatment Failure in HIV and / or AIDS -- 15.Drug Resistance in Reproductive Diseases -- 16.Drug Resistance in Diabetes -- 17.Drug Resistance in Rheumatological Diseases -- 18.Pherotypes in Streptococcus pneumoniae and Role of CSP-1 and CSP-2 in Antibiotic Susceptibility and Resistance; Towards Development of Live Attenuated Vaccine Candidates in Inducing Netosis Based Acquired Immune Response -- 19.Hypoxia, Obesity and Drug Resistance; Towards Sustainable Development Goals and Globalization -- 20.Genetic and Molecular Mechanisms of Multidrug-resistance in Uropathogens and Novel Therapeutic Combat -- 21.Drugs Resistance Management.
    Abstract: This book provides a comprehensive discussion on the current information and evidence on the latest developments in the field of drugs resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. This leads to negative outcomes at great risk of public health; therefore, increasing efforts are dedicated to the development of a new generation of medications that will help deal with this phenomenon. Decades of technological innovations in drug design have demonstrated the potential of resistance. Enormous information on various aspects of antibiotics resistance is available. However, literature on drug resistance specifically related to infectious and non-infectious diseases is rarely presented, particularly those focusing on the mechanisms, biochemistry, kinetics, dynamics, and management of drug resistance. Therefore, there is an immense need for a systematic compilation on the available information about this issue. All the chapters are logically selected and arranged to provide state-of-the-art information about all aspects of drugs resistance. After an introductory chapter, four chapters are dedicated to infectious microbial diseases, whereas two other chapters are complimenting this theme and focusing on drugs resistance in ear, nose and throat, and skin diseases. The recent advances in the understanding of drugs resistance in lung, neurological, kidney, heart, and liver diseases are also covered. Biochemistry of drugs resistance in cancer, HIV, ocular, reproductive, and diabetes diseases is also discussed. Finally, a chapter dedicated to the “management of drug resistance” has been included. .
    Type of Medium: Online Resource
    Pages: XI, 558 p. 97 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030763206
    URL: https://doi.org/10.1007/978-3-030-76320-6
    DOI: 10.1007/978-3-030-76320-6
    DDC: 616.9041
    Language: English
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  • 3
    Online Resource
    Online Resource
    Current Thoughts on Dementia : From Risk Factors to Therapeutic Interventions (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Neurosciences. ; Zoology. ; Medical genetics. ; Biotechnology. ; Medicine Research. ; Biology Research. ; Neuroscience. ; Zoology. ; Medical Genetics. ; Biotechnology. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. ApoE: A Risk Factor for Dementia -- Chapter 2. Infection-Induced Systemic Inflammation and Dementia -- Chapter 3. Role of Impaired Insulin Signaling in the Pathogenesis of Dementia -- Chapter 4. Sex Hormones as Risk Factors of Dementia -- Chapter 5. Mitophagy Impairments as Culprit of Alzheimer’s Disease -- Chapter 6. Parkinson’s Disease: Neurochemistry and Pharmacological Treatment -- Chapter 7. Emerging Roles of TREM2 in Neurodegenerative Diseases -- Chapter 8. Molecular Mechanisms Underlying the Role of HSPB8 in Neurodegeneration -- Chapter 9. Molecular Insights into the Role of ER Stress in Neurodegenerative Diseases. Chapter 10. Role of Hypertension and Hyperlipidemia in the Pathogenesis of Dementia -- Chapter 11. Behavioral Abnormalities of Gut Microbiota and Progression of Dementia -- Chapter 12. Gut-Brain Axis in Alzheimer's Disease: Interplay between Cholecystokinin, Dysbiosis, and Brain-Derived Neurotrophic Factor -- Chapter 13. Cholesterol and Dementia: A Possible Therapeutic Approach -- Chapter 14. Therapeutic Potential of PPARs in Alzheimer’s Disease -- Chapter 15. Exploring the Role of Statins in Reversing the Cognitive and Neurovascular Dysfunctions in Dementia -- Chapter 16. Role of Immunotherapy in Ameliorating Proteopathic Dementia -- Chapter 17. Hypoxic-Hyperoxic Training in Dementia -- Chapter 18. Music Therapy in Dementia -- Chapter 19. Beneficial Effects of Citrus Flavonoids against Aβ Pathology in Alzheimer’s Disease -- Chapter 20. Therapeutic Potential of Phytochemicals: Lessons Learned from Streptozotocin-Induced Sporadic Alzheimer’s Disease -- Chapter 21. Concept of Amnesia and Dementia in Unani System of Medicine -- Chapter 22. Nanotechnological Applications in the Diagnosis and Treatment of Alzheimer’s Dementia.
    Abstract: This informative book discusses the latest research on the risk factors and therapeutics in dementia. WHO calls dementia a public health priority. Dementia manifests as a group of symptoms associated with decline in memory or other thinking skills and is severe enough to reduce a person's ability to perform everyday activities. It occurs frequently among elderly people, but it is not necessarily part of the normal aging process. The book has been divided into two broad sections. The first section reviews the risk factors involved in developing dementia, including various medical conditions, lifestyle choices, as well as genetics. The latter section describes various therapeutic interventions in dementia. Although there is no known cure for dementia, this book underlines the current treatment strategies that could momentarily reduce the symptoms and improve the quality of life of the patients. This book highlights the global effort to find better ways to halt the progression of dementia and develop novel therapeutic strategies. The book would be an interesting read for advanced graduate students and researchers working in the field of neuroscience, genetics, and medicine. It will generate good interest to neurologists, psychiatrists, geriatricians, cardiologists, internal medicine practitioners, epidemiologist, and public health workers.
    Type of Medium: Online Resource
    Pages: XV, 624 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811676062
    URL: https://doi.org/10.1007/978-981-16-7606-2
    DOI: 10.1007/978-981-16-7606-2
    DDC: 612.8
    Language: English
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  • 4
    Online Resource
    Online Resource
    COVID-19 and Sleep: A Global Outlook (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Neurosciences. ; Public health. ; Medicine Research. ; Biology Research. ; Neuroscience. ; Public Health. ; Biomedical Research.
    Description / Table of Contents: 1. The effect of sleep disruption and circadian misalignment on the immune system -- 2. Changes in the sleep and circadian pattern of sleep during the COVID-19 pandemic -- 3. Anxiety and depression during the COVID-19 pandemic and their impact on sleep -- 4. Sleep problems during the COVID-19 pandemic in children and adolescents -- 5.Sleep problems during the COVID-19 pandemic in children and adolescents -- 6. Sleep disturbances among healthcare workers during the COVID-19 pandemic -- 7. Sleep disturbances among patients with COVID-19 infection -- 8. Sleep patterns and sleep disturbances during the lockdown periods -- 9. Impact of COVID-19 Mobility Restrictions on Sleep and Wellbeing -- 10. COVID-19 vaccines and sleep disturbances -- 11. Sleep during the COVID-19 pandemic: structural inequity and racial disparity -- 12. The effect of cognitive-behavioral therapy and coping strategies on sleep disturbances during the COVID-19 pandemic -- 13. Sleep and circadian rhythm in post-COVID-19 patients -- 14. COVID-19 and obstructive sleep apnea -- 15. The correlation between COVID-19 infection and restless legs syndrome -- 16. Impact of COVID-19 pandemic lockdown on disorders of hypersomnolence -- 17. Sleep, Physical Activity, and Diet Patterns During COVID-19 Pandemic -- 18. Impact of screen time during the pandemic of COVID-19 on sleep habits -- 19. Dreams and nightmares during the COVID-19 pandemic -- 20. The impact of the COVID-19 pandemic on sleep medicine services -- 21. Protocols for conducting sleep studies during pandemics -- 22. Management of hospital and home positive airway pressure machines during pandemics -- 23. Telemedicine and telemonitoring of sleep disorders during the COVID-19 pandemic -- 24.Changes in Positive Airway Pressure Application and Practices in Patients with Sleep-Related Breathing Disorder during the COVID-19 Pandemic -- 25. Potential Therapeutic Effects of Melatonin on SARS-CoV-2 Infection.
    Abstract: This book examines the correlation of the coronavirus disease-19 [CE1] [AAS2] (COVID-19) infection with sleep, circadian rhythm, and sleep disorders. The chapters of the book explore sleep problems during the COVID-19 pandemic and its association with psychological distress and also review the prevalence of clinical cases of insomnia, anxiety, and depression in COVID-19 patients. The book further presents the correlation between sleep, circadian rhythms, and immunity that contributes toward more severe COVID-19. It summarizes the evidence on the interplay between circadian biology, sleep, and COVID-19. The chapters of the book discuss the relationship between obstructive sleep apnea (OSA) and adverse COVID-19 outcomes. Towards the end, the book presents studies on the anti-inflammatory, antioxidant, and immunotropic properties of melatonin and provides mechanistic insights into the potential therapeutic use of melatonin during the SARS-CoV-2 infection. The last chapter describes the publication output of sleep-related research during the pandemic and provides an overview and trends on sleep and covid-19 publication output. This book is an excellent source for neurologists, sleep specialists, and public health specialists.
    Type of Medium: Online Resource
    Pages: XXVI, 430 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819902408
    Series Statement: Progress in Sleep Research,
    URL: https://doi.org/10.1007/978-981-99-0240-8
    DOI: 10.1007/978-981-99-0240-8
    DDC: 612.8
    Language: English
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  • 5
    Online Resource
    Online Resource
    Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology : Overview of the First Eukaryome Congress at Institut Pasteur. Paris, October 16–18, 2019. (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical microbiology. ; Parasitology. ; Microbiology. ; Medicine Research. ; Biology Research. ; Medical Microbiology. ; Parasitology. ; Microbiology. ; Biomedical Research.
    Description / Table of Contents: Eukaryome: Emerging field with profound translational potential -- Resolving amoebozoan encystation from Dictyostelium evo-devo and amoebozoan comparative genomics -- Integrative omics analysis of the effect of bacteria on the resistance of Entamoeba histolytica to oxidative stress -- Histomonas meleagridis molecular traits –from past to future -- Exploring the biology and evolution of Blastocystis and its role in the microbiome -- Advances in the study of Blastocystis spp. in Mexico: prevalence, genetic diversity, clinical association and their possible role in the human intestine -- Cryptosporidium infection in Bangladesh children -- The current molecular epidemiological scenario of Cryptosporidium, Giardia and Blastocystis in Spain. Implication for public health -- The protozoome of the periodontal sulcus: from health to disease -- Tritrichomonas spp. and Their Impact on Gut Immune Homeostasis -- Contribution of host immunity to the development of Entamoeba histolytica-induced liver abscess -- Oxidative Stress And Heat Stress In Experimental Amoebic Liver Abscess -- Role of Extracellular Traps promoted by intestinal parasites. Relationship with virulence -- Parasite secretory molecules in host-parasite interaction -- The Role of Host PKCα during Intracellular Cryptosporidium Infection -- Immune response triggered by Entamoeba histolytica in a 3D-intestinal model -- Receptors for phagocytosis and trogocytosis in Entamoeba histolytica -- PtdIns(3,4,5)P3 binding protein screening reveals unique molecules involved in endocytic processes -- Molecular insights into E. histolytica mediated host tissue invasion -- Vesicular trafficking in Entamoeba histolytica is essential for its virulence -- MOLECULAR CHARACTERIZATION OF Entamoeba histolytica tRNA GENES -- Gene silencing and overexpression to study pathogenicity factors of Entamoeba histolytica -- Polyadenylation machineries in intestinal parasites: latest advances in the protozoan parasite Entamoeba histolytica -- Probiotics as anti-Giardia defenders: Overview on putative control mechanisms -- A protocol to quantify cellular morphodynamics: from cell labelling to automatic image analysis.-.
    Abstract: The intestine is home to diverse bacterial communities forming the microbiome that influences host nutrition, immune functions and health. DNA-based methods have been instrumental to gain insight into the microbial eukaryotic diversity of the human gut. For instance, the microbiome share the intestinal ecosystem with a population of uni- and multi-cellular eukaryotic organisms. These eukaryotic organisms are very common and often very abundant in individuals with intestinal healthy conditions as well as those with intestinal diseases. The impact of the relationship between bacterial and eukaryotic organisms within the intestinal ecosystem on homeostasis and intestinal diseases is limited and can be considered an important emerging field of research. In addition, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. All these organisms and their interplay with bacteria and the human immune system are a challenge to assess the impact (present and future) of intestinal infectious diseases on public health. This book presents an overview of the science presented and discussed in the First Eukaryome Congress, held from October 16th to 18th, 2019 at Pasteur Institute in Paris, France. This contributed volume is of special interest for PhD students, postdoctoral fellows, researchers and clinicians interested in the effect of the eukaryotic microbiome on human health.
    Type of Medium: Online Resource
    Pages: XVII, 367 p. 60 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030448264
    URL: https://doi.org/10.1007/978-3-030-44826-4
    DOI: 10.1007/978-3-030-44826-4
    DDC: 616.9041
    Language: English
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  • 6
    Online Resource
    Online Resource
    Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Medicine Research. ; Biology Research. ; Proteins . ; Biology Technique. ; Neuroscience. ; Biomedical Research. ; Protein Biochemistry. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Peroxisome: metabolic functions and biogenesis -- Chapter 2. Peroxisomal Dysfunction and Oxidative Stress in Neurodegenerative Disease: A Bidirectional Crosstalk -- Chapter 3. 7-hydroxycholesterols-induced peroxisomal disorders in glial and microglial cells: potential role in neurodegeneration -- Chapter 4. Peroxisome biogenesis disorders -- Chapter 5. Fatty Acid Oxidation in Peroxisomes: Enzymology, Metabolic Crosstalk with Other Organelles And Peroxisomal Disorders -- Chapter 6. Zellweger syndrome disorders: from severe neonatal disease to atypical adult presentation -- Chapter 7. Heimler Syndrome -- Chapter 8. Potential involvement of peroxisome in multiple sclerosis and Alzheimer’s disease -- Chapter 9. Developmental and degenerative cerebellar pathologies in peroxisomal β-oxidation deficiency -- Chapter 10. A mouse model system to study peroxisomal role in neurodegenerative diseases such as peroxisome biogenesis disorders -- Chapter 11. The Drosophila melanogaster as genetic model system to dissect the mechanisms of disease that lead to neurodegeneration in adrenoleukodystrophy -- Chapter 12. Human peroxisomal 3-keto-acyl-CoA thiolase: tissue expression and metabolic regulation -- Chapter 13. Biological functions of plasmalogens -- Chapter 14. Therapeutic efficacy of plasmalogens for Alzheimer’s disease, Mild Cognitive Impairment and Parkinson’s disease in conjunction with a new hypothesis for the etiology of Alzheimer’s disease.
    Abstract: This book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases. It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation. The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer's, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment. This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.
    Type of Medium: Online Resource
    Pages: X, 212 p. 44 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030602048
    Series Statement: Advances in Experimental Medicine and Biology, 1299
    URL: https://doi.org/10.1007/978-3-030-60204-8
    DOI: 10.1007/978-3-030-60204-8
    DDC: 612.8
    Language: English
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  • 7
    Online Resource
    Online Resource
    Ketamine : From Abused Drug to Rapid-Acting Antidepressant (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Neurosciences. ; Pharmacology. ; Medicine Research. ; Biology Research. ; Neuropsychology. ; Neurology . ; Neuroscience. ; Pharmacology. ; Biomedical Research. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: 1.Determination of ketamine in the river of China -- 2.Ketamine abuse in Taiwan -- 3.Ketamine problem in Hong Kong -- 4. Hair analysis of ketamine -- 5. Brain imaging of ketamine abusers -- 6.Management of complications of ketamine abuse -- 7.Action site of ketamine in the NMDA receptor channel -- 8.Synaptic modulation in the effect of ketamine -- 9.Rodents whole-brain imaging in the effects of ketamine -- 10. Behavioral pharmacology of ketamine: An overview of preclinical studies -- 11.Antidepressant potential of ketamine enantiomers -- 12.Effects of ketamine on pain-related depression -- 13.Role of gut microbiota in the antidepressant actions of ketamine and its enantiomers -- 14. The role of NMDA receptor GluN2D subunit in the effects of ketamine and enantiomers -- 15.Roles of the lateral habenula in the actions of ketamine -- 16.Comparison of antidepressant action of ketamine and group II mGlu receptor antagonists -- 17.Antidepressant effects of ketamine in Taiwanese patients with treatment-resistant depression.
    Abstract: This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants. .
    Type of Medium: Online Resource
    Pages: V, 189 p. 27 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811529023
    URL: https://doi.org/10.1007/978-981-15-2902-3
    DOI: 10.1007/978-981-15-2902-3
    DDC: 612.8
    Language: English
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  • 8
    Online Resource
    Online Resource
    Gut Microbiota and Pathogenesis of Organ Injury (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medical microbiology. ; Human physiology. ; Medicine Research. ; Biology Research. ; Medical Microbiology. ; Human Physiology. ; Biomedical Research.
    Description / Table of Contents: Introduction -- Gut microbiota and alimentary tract injury -- Gut microbiota and liver injury - Acute liver injury -- Gut microbiota and liver injury - Chronic liver injury -- Gut microbiota and lung injury -- Gut microbiota and brain injury -- Gut microbiota and renal injury -- Gut microbiota and heart, vascular injury -- Gut microbiota and endocrine disorders -- Gut microbiota and immune responses -- Gut microbiota and multiple organ dysfunction syndrome (MODS).
    Abstract: This book aims to introduce the latest research in gut microbiota by systematically summarizing how it modulates the pathogenesis of organ injury including alimentary tract injury, liver injury, lung injury, brain injury, renal injury, heart and vascular injury, endocrine disorders, immune responses and multiple organ dysfunction syndrome (MODS) during sepsis. Gut microbiota which is recognized as a new “organ” in the body has been demonstrated to be able to regulate the homeostasis of many organs. The key role played by gut microbiota is the hotspot in biomedical research nowadays. This book provides a state-of-the-art report on recent discoveries regarding the novel insight into the mechanisms of human diseases progression. It will also offer the overall picture of the pathophysiologic roles of gut microbiota. This book is helpful for graduate students and professional researchers to get the knowledge of frontiers in both gut microbiota and organ injury.
    Type of Medium: Online Resource
    Pages: IX, 202 p. 18 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811523854
    Series Statement: Advances in Experimental Medicine and Biology, 1238
    URL: https://doi.org/10.1007/978-981-15-2385-4
    DOI: 10.1007/978-981-15-2385-4
    DDC: 616.9041
    Language: English
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  • 9
    Online Resource
    Online Resource
    Purinergic Signaling in Neurodevelopment, Neuroinflammation and Neurodegeneration (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neurochemistry. ; Medicine Research. ; Biology Research. ; Regenerative medicine. ; Neuroscience. ; Neurochemistry. ; Biomedical Research. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: The Purinergic Signaling: Overview -- Adenosine A2A Receptor-containing Heteromers and Neuroprotection -- Purinergic Signaling in Brain Physiology -- Neurotrophic Actions of Adenosine and Guanosine: Implications for Neural Development and Regeneration? -- Purinergic Signaling in Neurogenesis and Neural Fate Determination: Current Knowledge and Future Challenges -- Purinergic Signaling in Autism Spectrum Disorder -- Purinergic Signaling in Depression -- Roles of Purinergic Receptors in Alzheimer's Disease -- Purinergic Signaling in Basal Ganglia Diseases: Parkinson's Disease -- A Step in the ALS Direction: Lessons from the Purinome -- Purinergic P2 Receptors in Epilepsy -- Purinergic Signaling in Neuroinflammation -- Purinergic Signaling in Brain Tumors -- Development of Purinergic Receptor Agonists and Antagonists -- Acupuncture for Counteracting P2X4 and P2X7 Receptor Involvement in Neuroinflammation.
    Abstract: This volume explores the quickly evolving field of Purinergic signaling, and examines how receptors for ATP and other nucleotides, and receptors for adenosine, act in neuronal transmission, control of synaptic activity, proliferation, differentiation and cell death regulation in the CNS. This book focuses on the participation of purinergic receptors and ectonucleotidases, degrading ATP into adenosine, in embryonic and adult neurogenesis in vitro and in vivo as well as in synaptic transmission and pathophysiology. Further, the chapters discuss varying brain diseases, including Parkinson’s, and Alzheimer’s disease, autism, mood disorders and epilepsy, as well as brain tumors, in the context of purinergic signaling and its clinical aspects. The development of purinergic receptor agonists is also an important issue of this book. This book provides a critical review of the current state of science and will be useful for both scientists and students who are or would like to get involved in this area. Furthermore, this book addresses neuroscientists, physician and professionals from the industry, who would like to update themselves in this exciting and rapidly growing field of neuroscience.
    Type of Medium: Online Resource
    Pages: X, 376 p. 34 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031269455
    URL: https://doi.org/10.1007/978-3-031-26945-5
    DOI: 10.1007/978-3-031-26945-5
    DDC: 612.8
    Language: English
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