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  • Books  (33)
  • Journals
  • E-Books: Biomedical and Life Sciences (AWI only)  (33)
  • Stem Cell Biology.  (33)
  • 2020-2024  (33)
  • 571.6  (29)
  • 660.6  (4)
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  • Books  (33)
  • Journals
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  • E-Books: Biomedical and Life Sciences (AWI only)  (33)
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  • 2020-2024  (33)
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  • 1
    Online Resource
    Online Resource
    Stem Cells : Biology and Therapeutics (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Stem cells. ; Regenerative medicine. ; Molecular genetics. ; Biotechnology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Molecular Genetics. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Stem cells an Overview -- Chapter 2. Sources, Isolation and culture, of stem cells -- Chapter 3. Cryopreservation of stem cells -- Chapter 4. Glycosylation of stem cells -- Chapter 5. Sialylation of stem cells -- Chapter 6. Markers of stem cells -- Chapter 7. Cancer Stem cells -- Chapter 8. Next generation sequencing and stem cells -- Chapter 9. Nanoparticles and stem cells -- Chapter 10. Stem Cells in clinical research and therapy -- Chapter 11. Plant stem cell biology.
    Abstract: Stem cells hold great promise for cell therapy, tissue engineering, regenerative medicine and pharmaceutical and biotechnological applications. This book highlights the potency of stem cells, their property of self-renewal and their ability to differentiate into different cell lineages. It further describes the different markers to identify stem cells, sources, methods of isolation, culture including 2D, 3D and beyond and their cryopreservation. This is among the first books to discuss glycosylation and sialylation in stem cells. Chapters describe application of stem cells in regenerative medicine and therapy, and highlight their application in cancer therapy and spinal cord injury. The book talks about the important patents on stem cells. The book also highlights the plant stem cells, discussing their pluoripotent nature, role in organ regeneration after injury, specific stem cell niches, that signals to block differentiation studied in plants shoot, root, and vascular meristems, differentiation of plant stem cell, transcriptional regulation and epigenetic modification of plant stem cells. This book is exciting and cutting edge. It will be of great interest to doctors, students and researchers in the field of regenerative medicine, cancer , biotechnology and plant sciences.
    Type of Medium: Online Resource
    Pages: XI, 266 p. 43 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811616389
    URL: https://doi.org/10.1007/978-981-16-1638-9
    DOI: 10.1007/978-981-16-1638-9
    DDC: 571.6
    Language: English
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  • 2
    Online Resource
    Online Resource
    Regenerative Medicine and Stem Cell Biology (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Regenerative medicine. ; Reproductive health. ; Stem cells. ; Cancer. ; Biomedical engineering. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Reproductive Medicine. ; Stem Cell Biology. ; Cancer Biology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1. Basic Concepts of Stem Cells: The Facts and Hype in Stem Cells Research and Development -- Chapter 2. Embryonic and Pluripotent Stem Cells -- Chapter 3. Adult Stem Cells: Hematopoietic Stem Cells, and Control Of Hematopoiesis -- Chapter 4. Adult Stem Cells: Adult Stem Cells: Mesenchymal Stromal Cells, Endothelial Progenitor Cells and Pericytes -- Chapter 5. Cancer Stem Cells and the Development of Cancer -- Chapter 6. Stem Cell Applications In Metabolic Disorders: Diabetes Mellitus -- Chapter 7. Epigenetics in Stem Cell Biology -- Chapter 8. Practicum: Isolation of Bone Marrow and Adipose Tissue Mesenchyme Stromal Cells -- Chapter 9. Induced Pluripotent Stem Cells: Biology, History and in-vitro Generation -- Chapter 10. Tissue Engineering Modalities and Nanotechnology -- Chapter 11. Practicum: Scaffold engineering using the amniotic membrane -- Chapter 12. The Scientific Method, Ethical Consideration and Implications in Stem Cell Research.
    Abstract: This textbook covers the basic aspects of stem cell research and applications in regenerative medicine. Each chapter includes a didactic component and a practical section. The book offers readers insights into: How to identify the basic concepts of stem cell biology and the molecular regulation of pluripotency and stem cell development. How to produce induced pluripotent stem cells (iPSCs) and the basics of transfection. The biology of adult stem cells, with particular emphasis on mesenchymal stromal cells and hematopoietic stem cells, and the basic mechanisms that regulate them. How cancer stem cells arise and metastasize, and their properties. How to develop the skills needed to isolate, differentiate and characterize adult stem The clinical significance of stem cell research and the potential problems that need to be overcome. Evaluating the use of stem cells for tissue engineering and therapies (the amniotic membrane) The applications of bio-nanotechnology in stem cell research. How epigenetic mechanisms, including various DNA modifications and histone dynamics, are involved in regulating the potentiality and differentiation of stem cells. The scientific methods, ethical considerations and implications of stem cell research.
    Type of Medium: Online Resource
    Pages: X, 374 p. 45 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030553593
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-55359-3
    DOI: 10.1007/978-3-030-55359-3
    DDC: 660.6
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cell Biology and Translational Medicine, Volume 20 : Organ Function, Maintenance, Repair in Health and Disease (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Cytology. ; Stem cells. ; Cancer. ; Biophysics. ; Pharmacology. ; Regenerative medicine. ; Cell Biology. ; Stem Cell Biology. ; Cancer Biology. ; Biophysics. ; Pharmacology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Direct Cardiac Reprogramming: Current Status and Future Prospects -- Stem Cell-Based Therapeutic Approaches in Genetic Diseases -- Gene Therapeutic Delivery to the Salivary Glands -- Cancer Stem Cells and Their Therapeutic Usage -- Rafting on the Plasma Membrane: Lipid Rafts in Signaling and Disease -- Sounding a New Era in Biomechanics with Acoustic Force Spectroscopy -- Drug Therapeutics Delivery to the Salivary Glands: Intraglandular and Intraductal Injections -- Negative-Pressure Wound Therapy: What We Know and What We Need to Know -- Vitamin A Deficiency, COVID-19, and Rhino-Orbital Mycormycosis (Black Fungus): An Analytical Perspective -- Treatment Strategies for Multiple Myeloma Treatment and the Role of High-Throughput Screening for Precision Cancer Therapy. .
    Abstract: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 20th volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 189 p. 18 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031416880
    Series Statement: Cell Biology and Translational Medicine, 1436
    URL: https://doi.org/10.1007/978-3-031-41688-0
    DOI: 10.1007/978-3-031-41688-0
    DDC: 571.6
    Language: English
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  • 4
    Online Resource
    Online Resource
    Organoid Technology for Disease Modelling and Personalized Treatment (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Stem cells. ; Regenerative medicine. ; Diseases Animal models. ; Medicine Research. ; Biology Research. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Disease Models. ; Translational Research.
    Description / Table of Contents: Chapter 1. The hope and the hype in organoid technology in regenerative medicine (Badrul Hisham Yahaya) -- Chapter 2. Pluripotent stem cell derived and adult-tissue-derived organoid (Tiago G. Fernandes) -- Chapter 3. Generation of human organoid for 3D stem cell culture Hans Clevers -- Chapter 4. Organogenesis in a dish: Organ developmental study using organoid technology (Kursad Tuksen) -- Chapter 5. Disease modelling using patient-derived organoid (Narisorn Kitiyanant) -- Chapter 6. Tumor organoid as a model to study cancer microenvironment (Ahmad Faried) -- Chapter 7. Gene-editing in organoid to improve understanding of human disease (Yinming Liang) -- Chapter 8. Organoid culture as a good model to study lung development (Mitsuru Morimoto) -- Chapter 9. Organoid as good model for respiratory diseases (Badrul Hisham Yahaya).-Chapter 10. In vitro 3D model on reproductive system (Ruttachuk Rungsiwiwut) -- Chapter 11. Modelling of neuronal organoid: The way forward and challenges (Juntang Lin) -- Chapter 12. Generation of cardiac organoid in early heart organogenesis (Tan Jun Jie) -- Chapter 13. Neural Crest-Derived Stem Cells in organoid development for neurodegenerative disease modelling (Darius Widera) -- Chapter 14. Organoid for drug discovery and personalized treatment (Toshio Takahashi) -- Chapter 15. Ethical concern on patient-derived organoid (Phuc Van Pham).
    Abstract: Organoid Technology for Disease Modelling and Personalised Treatment provides a comprehensive overview of current knowledge of the organoid as a human-organ-in-a-dish, a powerful new technology for studying fundamental aspects of human organ development and disease progression in the search for drugs for personalised treatment. This preclinical tool is extensively being utilised as a model for studying human diseases in a dish, which is critical for accurate predictive modelling in precision medicine. The chapters in this book introduces readers to the numerous applications of organoids in various fields of study, as well as ethical considerations associated with organoids. In stem cell biology and regenerative medicine, where chimaera research, biomaterials for tissue vascularisation, gene-editing technologies, and their use in clinical procedures especially issues related to ethical concern over the use of human organoids have gotten much attention. Organoid Technology for Disease Modelling and Personalised Treatment is an excellent resource for in-depth research on one of the most interesting and significant topics in stem cell and regenerative medicine. This book's chapter collection covers a fresh viewpoint on organoid technology that scholars will require reading.
    Type of Medium: Online Resource
    Pages: VI, 208 p. 2 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030930561
    Series Statement: Stem Cell Biology and Regenerative Medicine, 71
    URL: https://doi.org/10.1007/978-3-030-93056-1
    DOI: 10.1007/978-3-030-93056-1
    DDC: 571.6
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cardiovascular Applications of Stem Cells (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Stem cells. ; Blood-vessels Growth. ; Cardiology. ; Stem Cell Biology. ; Angiogenesis. ; Cardiology.
    Description / Table of Contents: Chapter 1_Recent advances in in vitro generation of mature cardiomyocyte -- Chapter 2_Cardiac Reprogramming with Stem Cells: An Advanced Therapeutic Strategy in Advanced Heart Failure -- Chapter 3_Administration routes for advanced therapy medicinal products in patients with cardiovascular diseases -- Chapter 4_Cardiac Progenitor Cells, their Derivatives and Therapeutic Applications -- Chapter 5_Regenerative medicine: therapeutic insights from young cardiac stem cells -- Chapter 6_Rejuvenation and regenerative potential of heart stem cells -- Chapter 7_Cardiac Stem cells and utilization of atrial appendage microtissues or micrografts in the treatment of heart failure -- Chapter 8_Stem cells and regenerative medicine in valvulopathies -- Chapter 9_Cardiac tissue regeneration based on stem cell therapy -- Chapter 10_Stem Cell Applications in Cardiac Tissue Regeneration -- Chapter 11_Epicardial progenitors and stem cells in the cardiovascular applications -- Chapter 12_Human myoblast genome therapy and the regenerative heart -- Chapter 13_Exosomes and stem cell therapy -- Chapter 14_Mesenchymal stem cells in the clinical perspective for myocardial regeneration and repair -- Chapter 15_Towards the Human Induced Pluripotent Stem Cells (hiPSC)-derived Exosomes as Therapeutic Intervention for Cardiovascular Diseases -- Chapter 16_Stem cell- derived extracellular vesicles as next generation tools in regenerative medicine -- Chapter 17_Avant-garde Hydrogels as Stem Cell Niche for Cardiovascular Regenerative Medicine -- Chapter 18_Stem cell-derived cardiac organoids: past, present and future -- Chapter 19_Stem cell-based organoid engineering -- Chapter 20_Cardiovascular Stem Cell Applications Animal Models.
    Abstract: The book covers multifarious aspects of stem cell-based therapy for cardiovascular diseases. In addition to stem cells from different sources for cell-based therapy, it covers stem cell organoids and stem cell-derived exosomes in regenerative medicine. The book also encompasses advances in state-of-the-art infrastructure to improve the maturation aspects of pluripotent stem cells-derived cardiomyocytes using a novel scaffold-based cell culture system for cell delivery in experimental animal models and clinical settings. Besides the use of mesenchymal stem cells, the book includes chapters on the use of cardiac progenitor cells (CPCs), microtissue implantation, use of PSCs for valvulopathies, application of de-cellularized organ arrays as natural scaffolds for cardiac tissue engineering, use of epicardial stem cells, and skeletal myoblasts in cell-based therapy for myocardial regeneration. Besides the cell-based therapy approach, the book also reviews the stem cell-derived exosomes, their characteristics, and engineering strategies to enhance their therapeutic potential via targeting and drug loading and use in disease models. Additionally, the book also discusses the latest research on injectable hydrogels for cardiovascular regeneration and how hydrogel-based delivery protects the cells and their retention post-engraftment in the heart, a problem, which significantly reduces the efficacy of cell-based therapy.
    Type of Medium: Online Resource
    Pages: XI, 514 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819907229
    URL: https://doi.org/10.1007/978-981-99-0722-9
    DOI: 10.1007/978-981-99-0722-9
    DDC: 571.6
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cell Biology and Translational Medicine, Volume 15 : Stem Cells in Tissue Differentiation, Regulation and Disease (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Stem cells. ; Medicine Research. ; Biology Research. ; Cell Biology. ; Stem Cell Biology. ; Translational Research.
    Description / Table of Contents: Molecular Mechanisms of SARS-CoV-2/COVID-19 Pathogenicity on the Central Nervous System: Bridging Experimental Probes to Clinical Evidence and Therapeutic Interventions -- The Probable Protective Effect of Photobiomodulation on the Inflammation of the Airway and Lung in COVID-19 Treatment: A Preclinical and Clinical Meta-Analysis -- Metabolomics Signatures of SARS-CoV-2 Infection -- Autophagic Mediators in Bone Marrow Niche Homeostasis -- Pluripotency Stemness and Cancer: More Questions than Answers -- In Vitro Culturing of Adult Stem Cells: The Importance of Serum and Atmospheric Oxygen -- Mouse Models of Asthma: Characteristics, Limitations and Future Perspectives on Clinical Translation -- From Cells to Organs: The Present and Future of Regenerative Medicine -- Tissue-Restricted Stem Cells as Starting Cell Source for Efficient Generation of Pluripotent Stem Cells: An Overview -- Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium.
    Abstract: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s long-standing and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 15th volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 206 p. 31 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031023781
    Series Statement: Cell Biology and Translational Medicine, 1376
    URL: https://doi.org/10.1007/978-3-031-02378-1
    DOI: 10.1007/978-3-031-02378-1
    DDC: 571.6
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cell Biology and Translational Medicine, Volume 14 : Stem Cells in Lineage Specific Differentiation and Disease (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Stem cells. ; Medicine Research. ; Biology Research. ; Cell Biology. ; Stem Cell Biology. ; Translational Research.
    Description / Table of Contents: Recent Advances in the Generation of β-cells from Induced Pluripotent Stem Cells As a Potential Cure for Diabetes Mellitus -- Differentiated cells derived from hematopoietic stem cells and their applications in translational medicine -- Organoids in Tissue Transplantation -- Aldo keto reductases AKR1B1 and AKR1B10 in cancer: molecular mechanisms and signaling networks -- Bilayer Scaffolds for Interface Tissue Engineering and regenerative medicine: A Systematic Review -- Pluripotent Stem Cell Derived Neurons as In Vitro Models for Studying Autosomal Recessive Parkinson’s Disease (ARPD): PLA2G6 and Other Gene Loci -- Stem Cell Applications In Lysosomal Storage Disorders: Progress And Ongoing Challenges -- Mechanisms of Drug Resistance and Use of Nanoparticle Delivery to Overcome Resistance in Breast Cancers -- Telomere length and oxidative stress in patients with St-elevation and Non-St-elevation myocardial infarction -- Eosinophils as major player in Type 2 inflammation: autoimmunity and beyond.
    Abstract: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s long-standing and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 14th volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 224 p. 3 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030804923
    Series Statement: Cell Biology and Translational Medicine, 1347
    URL: https://doi.org/10.1007/978-3-030-80492-3
    DOI: 10.1007/978-3-030-80492-3
    DDC: 571.6
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cell Biology and Translational Medicine, Volume 11 : Stem Cell Therapy - Potential and Challenges (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Stem cells. ; Medicine Research. ; Biology Research. ; Cell Biology. ; Stem Cell Biology. ; Translational Research.
    Description / Table of Contents: Induced pluripotent stem cell derived human lung organoids to map and treat the SARS-CoV2 infections in vitro -- Embryonic Stem Cells in Clinical Trials: Current Overview of Developments and Challenges -- Functions of Mesenchymal Stem Cells in Cardiac Repair -- Cardiac Progenitor Cells -- Cardiac Immunology: a new era for immune cells in the heart -- Conventional and Alternative Mesenchymal Stem Cell Therapies for the Treatment of Diabetes -- Mesenchymal stem cells: The past present and future -- Extracellular vesicles therapeutics in regenerative medicine -- Exosomes as part of the human adipose-derived stem cells secretome- opening new perspectives for cell-free regenerative applications -- A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke.
    Abstract: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s long-standing and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the eleventh volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 181 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030719258
    Series Statement: Cell Biology and Translational Medicine, 1312
    URL: https://doi.org/10.1007/978-3-030-71925-8
    DOI: 10.1007/978-3-030-71925-8
    DDC: 571.6
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cell Biology and Translational Medicine, Volume 12 : Stem Cells in Development and Disease (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Stem cells. ; Medicine Research. ; Biology Research. ; Cell Biology. ; Stem Cell Biology. ; Translational Research.
    Description / Table of Contents: Immune dysregulation and recurring mutations in myelodysplastic syndromes pathogenesis -- Stem Cell Aging and Regenerative Medicine -- Potential of Chimeric Antigen Receptor T-cells in cancer therapy -- Drug sensitivity and drug repurposing platform for cancer precision medicine -- Role and regulation of Lin28 in progenitor cells during central nervous system development -- Cartilage Repair by Mesenchymal Stem Cell-Derived Exosomes: Preclinical and Clinical Trial Update and Perspective -- Kaempferol induce cell death and sensitizes human head and neck squamous cell carcinoma cell lines to cisplatin -- A comprehensive approach to Urticaria: from clinical presentation to modern biological treatments through pathogenesis -- The potentials and pitfalls of using adult stem cells in cancer treatment -- The Outcome of Stem Cell-Based Therapies on the Immune Responses in Rheumatoid Arthritis.
    Abstract: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s long-standing and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the twelfth volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 188 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030719333
    Series Statement: Cell Biology and Translational Medicine, 1326
    URL: https://doi.org/10.1007/978-3-030-71933-3
    DOI: 10.1007/978-3-030-71933-3
    DDC: 571.6
    Language: English
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  • 10
    Online Resource
    Online Resource
    Biology of Pericytes – Recent Advances (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Stem cells. ; Medicine Research. ; Biology Research. ; Human physiology. ; Physiology. ; Pathology. ; Stem Cell Biology. ; Biomedical Research. ; Human Physiology. ; Physiology. ; Pathology.
    Description / Table of Contents: In Vivo Optical Imaging and Manipulation of Brain Pericytes -- The complex and integral roles of pericytes within the neurovascular unit in health and disease -- Role of pericytes in brain metastasis -- Effects of Cytomegalovirus on Pericytes -- Pericytes in Retinal Ischemia -- Inflammatory mediators released by brain pericytes as sensors and effectors in blood-brain barrier dysfunction -- TLR-4 signaling in Pericytes -- EphA7+ Multipotent Pericytes and Their Roles in Multicellular Organisms -- Skeletal Muscle-Resident Pericyte Responses to Conditions of Use and Disuse -- Pericytes in myocardial diseases -- Adventitial and skeletal muscle pericytes in health and in ischemic tissue regeneration.
    Abstract: Pericytes were originally discovered and named more than hundred years ago as contractile cells around the blood vessel endothelial cells. Due to the lack of exclusive markers, pericytes are now defined by a combination of location, morphology and gene expression. Pericytes are attracting increasing attention as important regulators during development and during normal and disturbed organ function. In recent years, remarkable progress has been made in the identification and characterization of pericytes subpopulations and their amazing functions using state-of-art techniques. These advantages facilitated identification of molecular basis of interaction between these cells with several other more well studied cell types, and revealed key signals derived from pericytes involved in homeostasis, regeneration, and disease regulation. In the last ten years, several unexpected roles of pericytes have been discovered. It has been demonstrated that pericytes from different tissues differ in their properties as well as functions. Even more, pericytes are heterogeneous also within the same organ. This book is will describe the major contributions of pericytes to different organs biology in physiological and pathological conditions. The book will teach the readers about this so special cell type that 10 years ago was almost completely forgotten, and it was associated basically only with vascular stability. Recently, it become a very hot topic to work in. Several articles in Nature, Science and Cell have been and are being currently published about this cell type. These recent works are revealing how important those cells are for before unimaginable biological processes. Thus, this book will update us on what are the most novel functions attributed to these cells. Also, will introduce to the young generation all the history about these cells from when they were discovered in different organs till where we are now in this field. So it will be a great book for both cell biology students as well as researchers that will have an update on these cells biology in different organs.
    Type of Medium: Online Resource
    Pages: XI, 278 p. 51 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030621292
    Series Statement: Stem Cell Biology and Regenerative Medicine, 68
    URL: https://doi.org/10.1007/978-3-030-62129-2
    DOI: 10.1007/978-3-030-62129-2
    DDC: 571.6
    Language: English
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