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  • Books  (19)
  • Journals
  • E-Books: Biomedical and Life Sciences (AWI only)  (19)
  • Biomedical Engineering and Bioengineering.  (19)
  • 2020-2024  (19)
  • 660.6  (17)
  • 571.6  (2)
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  • Books  (19)
  • Journals
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  • E-Books: Biomedical and Life Sciences (AWI only)  (19)
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  • 2020-2024  (19)
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  • 1
    Online Resource
    Online Resource
    Biopharmaceutical Manufacturing : Progress, Trends and Challenges (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Biomedical engineering. ; Biotechnology. ; Biochemical engineering. ; Pharmaceutical chemistry. ; Vaccines Biotechnology. ; Biomaterials. ; Cell Biology. ; Biomedical Engineering and Bioengineering. ; Biotechnology. ; Bioprocess Engineering. ; Pharmaceutics. ; Biomaterials-Vaccines.
    Description / Table of Contents: Part I: Manufacturing of Recombinant Therapeutic Proteins -- Chapter 1. Single-Use Systems in Biopharmaceutical Manufacture: State of the Art and Recent Trends (Jossen et al.) -- Chapter 2. Recent Developments in Bioprocess Monitoring Systems (Rahmatnejad et al.) -- Chapter 3. Advances in Characterization of Industrial Bioreactors for Cell Culture Process (Fitschen et al.) -- Chapter 4. Continuous Bioprocessing for Upstream Process - Perfusion Process (Chotteau et al.) -- Chapter 5. Continuous Bioprocessing for Downstream (Gerstweiler) -- Chapter 6. Towards Digital Twin for Biopharmaceutical Processes: Concept and Progress (Ding et al.) -- Chapter 7. Integrated Process and Supply Chain Design and Optimization (Triantafyllou et al.) -- Chapter 8. Production of Complex Proteins in Plants – From Farming to Manufacturing (Nausch et al.) -- Chapter 9. Manufacturing of Recombinant Proteins Using Quality by Design (QbD) Methodology: Current Trend and Challenges (Shin and Landauer) -- Chapter 10. Biopharma 4.0 for Biologics Manufacturing Under Pandemic Constraints (Schmidt et al.) -- Chapter 11. Biopharma 4.0: Digital Technologies Driving Smart Manufacturing (Nargund et al.) -- Part II: Manufacturing Aspects of Cell and Gene Therapy -- Chapter 12. Essential Aspects of Mesenchymal Stem Cell Manufacturing (Fleischhammer et al.) -- Chapter 13. Towards a Continuous Production of Human Mesenchymal Stromal Cells in a Chemically Defined Medium: Opportunities and Challenges for a Robust and Scalable Expansion Process (Tasto and Salzig) -- Chapter 14. Biomanufacturing Aspects of Gene Therapy (Warnock) -- Chapter 15. Manufacturing and Quality of Advanced Therapeutics: Cellular Therapies, CAR-T and Gene Therapies (van den Bos et al.).
    Abstract: This volume “Cell Engineerring 11 - Biopharmaceutical Manufacturing: Progress, Trends and Challenges” is a source of the latest innovative research and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing productivity/efficiency, Model-assisted process understanding and development/Digital Twins, Process controls and analytics, Quality control, Quality by design, Facility design and full-scale commercial systems, manufacturing technology innovation. The book comprises contributions of experts from academia and industry active in the field of cell culture development for the production of recombinant proteins, cell therapy and gene therapy, with consideration of Digital Twin´s and facility design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. Inevitably, some omissions will occur in the test, but the authors have sought to avoid duplications by extensive cross-referencing to chapters in other volumes of this series and elsewhere. We hope the volume provides a useful compendium of techniques for scientists in industrial and research laboratories active in this field.
    Type of Medium: Online Resource
    Pages: IX, 495 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031456695
    Series Statement: Cell Engineering, 11
    URL: https://doi.org/10.1007/978-3-031-45669-5
    DOI: 10.1007/978-3-031-45669-5
    DDC: 571.6
    Language: English
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  • 2
    Online Resource
    Online Resource
    Ultra-Weak Photon Emission from Biological Systems : Endogenous Biophotonics and Intrinsic Bioluminescence (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Medicine Research. ; Biology Research. ; Biomedical engineering. ; Biotechnology. ; Biomedical Research. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Introduction -- Part 1. History of UPE research -- Mitogenetic rays -- Oxidation, free-radicals and ultraweak luminescence -- Biophotons and the International Institute of Biophysics (IIB) -- Part 2. Physics of light and light research -- Physics of photon emission -- Chemiluminescence as a tool for free radical research -- Highly sensitive imaging and spectral analysis of UPE from biological systems and their application -- Part 3. Molecular mechnisms of UPE -- Free radicals in biology -- Ultraweak luminescence from aqueous systems -- Chemiluminescence in oxidation of hydrocarbons: mechanistic fundamentals -- Chemiluminescence in oxidation of fatty acids and lipids -- Chemiluminescence in protein oxidation -- Emitters of endogenous biological chemiluminescence: quantum chemical modeling insights -- Enzymatic sources of free radicals -- Part 4. UPE research in life science -- Luminescence of animal tissues and vegetable oils -- Ultraweak photon emission from human body in relation to anatomy and histology -- Chronobiological aspects of spontaneous ultra-weak photon emission in humans: Ultradian, circadian and infradian rhythms -- Autoluminescence in seedlings: applications -- Application potentiality of Delayed Luminescence in Medicine, Biology and Food Quality researches -- Part 5. Mitogenetic effect and related phenomena: unresolved problems of UPE -- Mitogenetic effect: preface -- Mitogenetic effect in biological systems -- Physical properties of mitogenetic radiation -- Secondary, degradation and necrobiotic radiation -- Mitogenetic research in medicine: radiation of blood and cancer diagnostics -- Part 6. Non-chemical distant interaction hypothesis - pro et contra -- Non-chemical distant interaction: preface -- The possible functions of electromagnetic cell communication -- Understanding of Fritz-Albert Popp’s biophoton theory from the viewpoint of a biologist -- Limits to the information transfer through UPE -- Quantum nonlocality and biological coherence -- Part 7. Perspectives -- Integrating ultraweak photon emission in mitochondrial research -- Selected biophysical methods for enhancing biological autoluminescence -- Upconverting nanoparticles as sources of singlet oxygen -- Upconverting nanoparticles as sources of singlet oxygen -- Delayed Luminescence as a tool to study the structures of systems of biological interest and their collective long-living excited states -- Index.
    Abstract: This book addresses the phenomenon of biological autoluminescence (also known as ultraweak photon emission, UPE, biochemiluminescence, or biophotons) and deals with a very broad spectrum of subjects, ranging from basic observational studies to molecular mechanisms, free-radical processes, physics of electron excitation and photon emission, as well as detection techniques. The chapter topics include UPE in plants, animals, and the human body; microorganisms and subcellular structures; and model systems, illustrating its high prevalence. Several sections of the book provide some backstory, with emphasis on methodology, unresolved questions, and existing controversies. The authors raise and discuss complex, potentially divisive aspects: Are there any reasons to assume the existence of non-chemical interaction in biological systems? Can research results in the field of mitogenetic radiation, delayed luminescence, and oxychemiluminescence of model systems, be correctly interpreted? What does the future hold for this area of research? Altogether, this publication gives the reader a thorough overview of biological autoluminescence (UPE, biophotonics) research, making it ideal for students and researchers who are new to the area as well as those who are specializing in it.
    Type of Medium: Online Resource
    Pages: XII, 521 p. 345 illus., 198 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031390784
    URL: https://doi.org/10.1007/978-3-031-39078-4
    DOI: 10.1007/978-3-031-39078-4
    DDC: 660.6
    Language: English
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  • 3
    Online Resource
    Online Resource
    Regenerative Medicine and Stem Cell Biology (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Regenerative medicine. ; Reproductive health. ; Stem cells. ; Cancer. ; Biomedical engineering. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Reproductive Medicine. ; Stem Cell Biology. ; Cancer Biology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1. Basic Concepts of Stem Cells: The Facts and Hype in Stem Cells Research and Development -- Chapter 2. Embryonic and Pluripotent Stem Cells -- Chapter 3. Adult Stem Cells: Hematopoietic Stem Cells, and Control Of Hematopoiesis -- Chapter 4. Adult Stem Cells: Adult Stem Cells: Mesenchymal Stromal Cells, Endothelial Progenitor Cells and Pericytes -- Chapter 5. Cancer Stem Cells and the Development of Cancer -- Chapter 6. Stem Cell Applications In Metabolic Disorders: Diabetes Mellitus -- Chapter 7. Epigenetics in Stem Cell Biology -- Chapter 8. Practicum: Isolation of Bone Marrow and Adipose Tissue Mesenchyme Stromal Cells -- Chapter 9. Induced Pluripotent Stem Cells: Biology, History and in-vitro Generation -- Chapter 10. Tissue Engineering Modalities and Nanotechnology -- Chapter 11. Practicum: Scaffold engineering using the amniotic membrane -- Chapter 12. The Scientific Method, Ethical Consideration and Implications in Stem Cell Research.
    Abstract: This textbook covers the basic aspects of stem cell research and applications in regenerative medicine. Each chapter includes a didactic component and a practical section. The book offers readers insights into: How to identify the basic concepts of stem cell biology and the molecular regulation of pluripotency and stem cell development. How to produce induced pluripotent stem cells (iPSCs) and the basics of transfection. The biology of adult stem cells, with particular emphasis on mesenchymal stromal cells and hematopoietic stem cells, and the basic mechanisms that regulate them. How cancer stem cells arise and metastasize, and their properties. How to develop the skills needed to isolate, differentiate and characterize adult stem The clinical significance of stem cell research and the potential problems that need to be overcome. Evaluating the use of stem cells for tissue engineering and therapies (the amniotic membrane) The applications of bio-nanotechnology in stem cell research. How epigenetic mechanisms, including various DNA modifications and histone dynamics, are involved in regulating the potentiality and differentiation of stem cells. The scientific methods, ethical considerations and implications of stem cell research.
    Type of Medium: Online Resource
    Pages: X, 374 p. 45 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030553593
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-55359-3
    DOI: 10.1007/978-3-030-55359-3
    DDC: 660.6
    Language: English
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  • 4
    Online Resource
    Online Resource
    Biomechanics for Instructors (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Medicine History. ; Biomedical engineering. ; Biotechnology. ; History of Medicine. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Introduction by Vera L. Talis -- Lecture 1 -- Lecture 2 -- Lecture 3 -- Lecture 4 -- Lecture 5 -- Lecture 6 -- Lecture 7 -- Lecture 8 -- Lecture 9 -- Lecture 10.
    Abstract: This book comprises a series of lectures given by celebrated Soviet neurophysiologist Nikolai Alexandrovich Bernstein in Moscow in 1925 and first published in Russian in 1926. Bernstein’s groundbreaking work, which has had a significant influence on the development of neuroscience, movement studies, and other fields of study in Russia, Eastern Europe, and the West, was suppressed during Stalin’s regime. At the time of its publication, Biomechanics for Instructors was a significant resource for teachers, with its descriptions of the movement of joints and degrees of freedom, illustrations of how to calculate the work capacity of muscles with bones acting as levers, the role of the central nervous system in movement, and more. Though the terminologies and methods have changed and been updated as research and technologies have progressed, the book remains a valuable introduction for those interested in Bernstein’s work more generally, and to those involved in the study of biomechanics. This book is also of interest to historians and philosophers of neuroscience, as well as those involved in movement studies in both the scientific and artistic domains, and to physiotherapists and those involved in sports research and practice.
    Type of Medium: Online Resource
    Pages: XXXIII, 155 p. 86 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030361631
    URL: https://doi.org/10.1007/978-3-030-36163-1
    DOI: 10.1007/978-3-030-36163-1
    DDC: 660.6
    Language: English
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  • 5
    Online Resource
    Online Resource
    Basic Concepts on 3D Cell Culture (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Cytology Technique. ; Biomedical engineering. ; Regenerative medicine. ; Biotechnology. ; Cytological Techniques. ; Biomedical Engineering and Bioengineering. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Chapter 1. Introduction to 3D cell culture -- Chapter 2. Lab equipment for 3D cell culture -- Chapter 3. A view from the cellular perspective -- Chapter 4. Biological, natural and synthetic 3D matrices -- Chapter 5. Hydrogels for 3D cell culture -- Chapter 6. Vascularization in 3D cell culture -- Chapter 7. Application of scaffold-free 3D models -- Chapter 8. 10. Microfluidic Systems and Organ (Human) on a Chip -- Chapter 9. 3D-Bioprinting -- Chapter 10. Non-destructive and label-free monitoring of 3D cell constructs.
    Abstract: This textbook shall introduce the students to 3D cell culture approaches and applications. An overview on existing techniques and equipment is provided and insight into various aspects and challenges that researchers need to consider and face during culture of 3D cells is given. The reader will learn the importance of physiological cell, tissue and organ models and gains important knowledge on 3 D analytics. This textbook deepens selected aspects of the textbook “Cell Culture Technology”, which also is published in this series, while offering extended insight into 3D cell culture. The concept of the textbook encompasses various lectures ranging from basics in cell cultivation, tissue engineering, biomaterials and biocompatibility, in vitro test systems and regenerative medicine. The textbook addresses Master- and PhD students interested and/or working in the field of modern cell culture applications and will support the understanding of the essential strategies in 3D cell culture and waken awareness for the potentials and challenges of this application.
    Type of Medium: Online Resource
    Pages: XV, 252 p. 88 illus., 83 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030667498
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-66749-8
    DOI: 10.1007/978-3-030-66749-8
    DDC: 660.6
    Language: English
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  • 6
    Online Resource
    Online Resource
    Advances in Application of Stem Cells: From Bench to Clinics (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Stem cells. ; Medicine Research. ; Biology Research. ; Regenerative medicine. ; Biomedical engineering. ; Stem Cell Biology. ; Translational Research. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Basics of stem cell biology -- Types and classifications stem cells -- Method of isolation and characterization of stem cells -- Differentiation of stem cells into neuronal lineage: In vitro cell culture, In vivo transplantation in animal models -- Differentiation of stem cells into cardiomyocyte lineage: In vitro cell culture, In vivo transplantation in animal models -- Differentiation of stem cells into hepatocyte lineage: In vitro cell culture, In vivo transplantation in animal models -- Differentiation of stem cells into pancreatic lineage: In vitro cell culture, In vivo transplantation in animal models -- Application of stem cells in treatment of bone diseases: pre-clinical and clinical perspectives -- Stem cells in regenerative medicine: clinical trials -- Stem cell production: Scale up, GMP production, Bioreactor -- Stem cell based products in the market -- Commercialization, IPR and market of stem cell products.
    Abstract: The field of stem cell biology is expanding with a continued surge of new information related to its applications. Over past few years, stem cells have been extensively used in cell therapy, tissue engineering, in vitro drug testing among others. At the moment there is no single book available which comprehensively describes the significance of various application of stem cells derived from embryonic and adult sources from lab to clinics. In this edited volume, we discuss basics and advanced topics of stem cells to help researchers, students and professional find the most important information in a single source of updated information about stem cells and relevant applications. This book is divided in 12 chapters and covers topics such as in vitro cell culture, 3D cell culture, cell therapy, tissue engineering, cell factory, cell functionality, in vitro drug testing, organ development, autologous transplantation, allogeneic transplantation, adult stem cells, multipotent stem cells, induced pluripotent stem cells, a pluripotent and embryonic stem cells.
    Type of Medium: Online Resource
    Pages: XI, 316 p. 36 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030781019
    Series Statement: Stem Cell Biology and Regenerative Medicine, 69
    URL: https://doi.org/10.1007/978-3-030-78101-9
    DOI: 10.1007/978-3-030-78101-9
    DDC: 571.6
    Language: English
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  • 7
    Online Resource
    Online Resource
    Deep Learning in Medical Image Analysis : Challenges and Applications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Biomedical engineering. ; Radiology. ; Bioinformatics. ; Biotechnology. ; Biomedical Engineering and Bioengineering. ; Radiology. ; Computational and Systems Biology.
    Description / Table of Contents: Deep Learning in Medical Image Analysis -- Medical Image Synthesis via Deep Learning -- Deep Learning for Pulmonary Image Analysis: Classification, Detection, and Segmentation -- Deep Learning Computer Aided Diagnosis for Breast Lesion in Digital Mammogram -- Decision support system for lung cancer using PET/CT and microscopic images -- Lesion Image Synthesis using DCGANs for Metastatic Liver Cancer Detection -- Retinopathy analysis based on deep convolution neural network -- Diagnosis of Glaucoma on retinal fundus images using deep learning: detection of nerve fiber layer defect and optic disc analysis -- Automatic segmentation of multiple organs on 3D CT images by using deep learning approaches -- Techniques and Applications in Skin OCT Analysis -- Deep Learning Technique for Musculoskeletal Analysis -- Index.
    Abstract: This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems. Each of its chapters covers a topic in depth, ranging from medical image synthesis and techniques for muskuloskeletal analysis to diagnostic tools for breast lesions on digital mammograms and glaucoma on retinal fundus images. It also provides an overview of deep learning in medical image analysis and highlights issues and challenges encountered by researchers and clinicians, surveying and discussing practical approaches in general and in the context of specific problems. Academics, clinical and industry researchers, as well as young researchers and graduate students in medical imaging, computer-aided-diagnosis, biomedical engineering and computer vision will find this book a great reference and very useful learning resource.
    Type of Medium: Online Resource
    Pages: VIII, 181 p. 131 illus., 114 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030331283
    Series Statement: Advances in Experimental Medicine and Biology, 1213
    URL: https://doi.org/10.1007/978-3-030-33128-3
    DOI: 10.1007/978-3-030-33128-3
    DDC: 660.6
    Language: English
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  • 8
    Online Resource
    Online Resource
    Advances in the Diagnosis and Treatment of Sleep Apnea : Filling the Gap Between Physicians and Engineers (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Neurology . ; Biomedical engineering. ; Biotechnology. ; Neurology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Section A Physiology -- An Overview On Sleep Medicine -- Covering The Gap Between Sleep And Cognition – Mechanisms and Clinical Examples -- Obstructive sleep apnoea: Focus on Pathophysiology -- Diagnosis of obstructive sleep apnea in patients with associated comorbidity -- Pediatric Obstructive Sleep Apnea: What’s in a Name? -- Treatment of Cheyne-Stokes respiration in heart failure with adaptive servo-ventilation: An integrative model -- Section B Diagnostic innovations -- Automated scoring of sleep and associated events -- Conventional machine-learning methods applied to the automatic diagnosis of sleep apnea -- Home Sleep Testing of Sleep Apnea -- ECG and heart rate variability in sleep-related breathing disorders -- Cardiopulmonary Coupling -- Pulse oximetry: the working principle, signal formation, and applications -- Oximetry indices in the management of sleep apnea: from overnight minimum saturation to the novel hypoxemia measures -- Airflow Analysis In The Context OF Sleep Apnea -- Deep-learning Model Based on Convolutional Neural Networks to Classify Apnea-hypopnea Events From The Oximetry Signal -- Tracheal sound analysis -- Obstructive Sleep Apnea with COVID-19 -- Section C Therapeutic innovations -- APAP, BPAP, CPAP and new modes of positive airway pressure therapy -- Adherence monitoring using telemonitoring techniques -- Innovations in The Treatment of Pediatric Obstructive Sleep Apnea -- Hypoglossal Nerve Stimulation Therapy -- Anna M. Mohammadieh -- Index.
    Abstract: The book focuses on biomedical innovations related to the diagnosis and treatment of sleep apnea. The latest diagnostic tools are described, including sleep laboratory equipment, wearables, and even smartphone apps. Innovative medical devices for treatment are also covered, such as CPAP, Auto-PAP, hypoglossal nerve stimulation, phrenic nerve stimulation, acoustic brain stimulation and electrical brain stimulation. This is an ideal book for biomedical engineers, pneumologists, neurologists, cardiologists, physiologists, ENT physicians, pediatrics, and epidemiologists who are interested in learning about the latest technologies in treating and diagnosing sleep apnea. Chapter 12 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XI, 389 p. 68 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031064135
    Series Statement: Advances in Experimental Medicine and Biology, 1384
    URL: https://doi.org/10.1007/978-3-031-06413-5
    DOI: 10.1007/978-3-031-06413-5
    DDC: 660.6
    Language: English
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  • 9
    Online Resource
    Online Resource
    Electrical Properties of Tissues : Quantitative Magnetic Resonance Mapping (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Radiology. ; Biomedical engineering. ; Neurosciences. ; Biotechnology. ; Radiology. ; Biomedical Engineering and Bioengineering. ; Neuroscience.
    Description / Table of Contents: Electromagnetic Properties and the Basis for CDI, MREIT and EPT -- Modeling for Electromagnetic Characterization, Prediction and Reconstruction -- Magnetic Resonance Imaging Basics -- Phantom Construction and Equipment Configurations for Characterizing Electrical Properties using MRI -- MR Current Density and MREIT Data Acquisition -- Magnetic Resonance Current Density Imaging (MR-CDI) -- Magnetic Resonance Electrical Impedance Tomography -- Index.
    Abstract: This book covers the latest developments in tissue electrical conductivity and current density imaging, increasingly popular as well as challenging applications of MRI. These applications are enabled by the acquisition of high-quality MR phase images. This book provides a practical description of the MRI physics needed to understand and acquire phase images in MRI and the key details required to reconstruct them into conductivity, current density or electric field distributions. Comprehensive details are provided about the electrical properties of biological tissues, computational modeling considerations, experimental methods, construction of non-biological and biological phantoms and MRI pulse sequences. An inclusive review of image reconstruction algorithms, and their potential applications is provided for applications directed at determining current density or electric fields, such as in transcranial DC or AC stimulation techniques; as well as electrical conductivity reconstructions that may be of use in quantitative MRI applications used to detect cancer or other pathologies. This is an excellent book for undergraduate and graduate students beginning to explore phase, current density, and conductivity imaging in MRI, and will also be of great use to researchers interested in the area of MR-based electrical property imaging.
    Type of Medium: Online Resource
    Pages: VII, 206 p. 101 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031038730
    Series Statement: Advances in Experimental Medicine and Biology, 1380
    URL: https://doi.org/10.1007/978-3-031-03873-0
    DOI: 10.1007/978-3-031-03873-0
    DDC: 660.6
    Language: English
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  • 10
    Online Resource
    Online Resource
    Advanced Imaging and Bio Techniques for Convergence Science (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Biomedical engineering. ; Biotechnology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: 1.Confocal laser scanning microscopy and fluorescence correlation methods for evaluation of molecular interactions -- 2.Number and Brightness Imaging: visualization of protein oligomerization state in living cell -- 3.Single-molecule analysis on the coupling of molecular state and reaction kinetics -- 4.Imaging lipid rafts in the plasma membrane using novel probe and super-resolution microscopy -- 5.Multiplex Immunohistochemistry (IHC) -- 6.Micro-endoscopy for live small animal fluorescent imaging -- 7.Immuno-gold techniques -- 8.Correlative Light and Electron Microscopy for Nanoparticle-Cell Interaction -- 9.Diagnostic and Therapeutic Nanomedicine -- 10.Semiconductor nanocrystals for biological imaging and fluorescence spectroscopy -- 11.DNA/RNA fluorescence imaging by synthetic nucleic acids -- Section II: Label-free techniques and advanced tomographic imaging -- 12.“Magnetic resonance imaging for preclinical study -- 13.Holotomography techniques for 3D label-free imaging of live cells and tissues -- 14.Dynamic-contrast optical imaging techniques -- 15.Emerging biological and clinical applications of photoacoustic tomography -- Section III: Potential (synergic) biotechnologies to be joined with imaging techniques -- 16.Generation of genetically-engineered mouse models using CRISPR-Cas system -- 17.Highly efficient generation of cell lines stably expressing genes of interest via Cre recombinase mediated knock-in method in mouse embryonic stem (ES) cells and its application for microscopic imaging techniques -- 18.Mass spectrometry based metabolomics in translational research -- 19.Application of mass spectrometry in drug metabolism and pharmacokinetics for drug development -- 20.Discovery and Application of Chemical Probes for Translational Research -- 21.Regeneration of skin cells by mesenchymal stem cell-derived exosomes.
    Abstract: This book is a wide-ranging guide to advanced imaging techniques and related methods with important applications in translational research or convergence science as progress is made toward a new era in integrative healthcare. Conventional and advanced microscopic imaging techniques, including both non-fluorescent (i.e., label-free) and fluorescent methods, have to date provided researchers with specific and quantitative information about molecules, cells, and tissues. Now, however, the different imaging techniques can be correlated with each other and multimodal methods developed to simultaneously obtain diverse and complementary information. In addition, the latest advanced imaging techniques can be integrated with non-imaging techniques such as mass spectroscopic methods, genome editing, organic/inorganic probe synthesis, nanomedicine, and drug discovery. The book will be of high value for researchers in the biological and biomedical sciences or convergence science who need to use these multidisciplinary and integrated techniques or are involved in developing new analytical methods focused on convergence science. .
    Type of Medium: Online Resource
    Pages: VI, 564 p. 191 illus., 161 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813360648
    Series Statement: Advances in Experimental Medicine and Biology, 1310
    URL: https://doi.org/10.1007/978-981-33-6064-8
    DOI: 10.1007/978-981-33-6064-8
    DDC: 660.6
    Language: English
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