ALBERT

Description / Table of Contents: Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling -- Overview of Basic Mechanisms of Notch Signaling in Development and Disease -- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate -- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling -- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster -- Molecular Regulation of Notch Signaling by Gremlin -- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex -- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss -- Insulin–dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation -- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF-κB and beyond -- Index.

Description / Table of Contents: MicroRNAs in the tumor microenvironment -- The Impact of Estrogen in the Tumor Microenvironment -- The non-bone related role of RANK/RANKL signaling in cancer -- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment -- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma -- COX-2 Signaling in the Tumor Microenvironment -- Renin–angiotensin system in the tumor microenvironment -- Stem cell secreted factors in the tumor microenvironment -- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy -- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms -- Index.

Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Unconventional functions of transcription factors -- GAGA transcription factor -- Heterochromatin protein 1 -- Retinoblastoma protein -- STAT -- ATF-2 -- NF-kB -- Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer -- STAT and HP1 promote longevity -- STAT and HP1 protect against DNA damage -- Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model -- Chapter 4 The possible biological significance of transcription factors’ unconventional functions -- The epigenome -- Processes in the cell nucleus -- Future Work.

Description / Table of Contents: Introduction to genes, oncogenes, and anti-oncogenes -- Introduction to free radicals (including nitric oxide), antioxidants, lipid peroxidation and their effects on cell proliferation -- Immune system, inflammation and essential fatty acids and their metabolites in cancer -- PUFAs and their metabolites in carcinogenesis -- Molecular mechanism of anti-cancer action of PUFAs with particular reference to GLA in glioma -- Bioactive lipids (BAL)-based therapeutic approach to cancer that enhances anti-tumor action and ameliorates cytokine release syndrome of immune check point inhibitors -- A new therapeutic strategy to treat cancer based on bioactive lipids (BAL) -- Index.

Description / Table of Contents: Economic/Academic importance -- Background of the sequencing initiatives -- Molecular mapping and cloning of genes and QTLs -- Physical mapping of the genome -- Whole genome sequencing and assembling -- Structure and composition of centromere in Brassica genome -- Genome annotation -- Gene loss -- Alternative splicing -- Gene conversion -- Gene family differentiation in Brassica species -- Glucosinates -- R genes variations after triplication -- Structural & functional genomic resources developed -- Impact on plant breeding and crop improvement -- Data bases -- Future prospects.

Description / Table of Contents: Application of iPSC to modelling of respiratory diseases -- Gene editing in human pluripotent stem cells: recent advances for clinical therapies -- Vascular wall as source of stem cells able to differentiate into endothelial cells -- Physiological and therapeutic roles of neuropeptide Y on biological functions -- Rho signaling-directed YAP/TAZ regulation encourages 3D spheroid colony formation and boosts plasticity of Parthenogenetic Stem Cells -- Transamniotic Stem Cell Therapy -- Regenerative medicine: Injectable cell-based therapeutics and approved products -- Stem Cell Therapy for Hepatocellular Carcinoma: Future Perspectives -- Potential of tribological properties of metalnanomaterials in biomedical applications -- The impact of the low frequency of the electromagnetic field on human.

Description / Table of Contents: Introduction -- Batch Processing Methods in ImageJ -- Python: Data Handling, Analysis and Plotting -- Building a Bioimage Analysis Workflow Using Deep Learning -- GPU-Accelerating ImageJ Macro Image Processing Workflows Using CLIJ -- How to Do the Deconstruction of Bioimage Analysis Workflows: A Case Study with SurfCut -- i.2.i. with the (Fruit) Fly: Quantifying Position Effect Variegation in Drosophila Melanogaster -- A MATLAB Pipeline for Spatiotemporal Quantification of Monolayer Cell Migration.

Description / Table of Contents: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.

Description / Table of Contents: Chapter 1. A Systemic View of Metastatic Disease: Inter-organ Crosstalk and Therapeutic Implications -- Part I. Systemic Regulation in Metastatic Disease -- Chapter 2. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles -- Chapter 3. Bone Metastasis: Systemic Regulation and Impact on Host -- Chapter 4. Targeting Metastatic Disease: Challenges and New Opportunities -- Part II. Cachexia: A Debilitating Systemic Effect of Cancer -- Chapter 5. Signaling Pathways That Promote Muscle Catabolism in Cachexia -- Chapter 6. The Role of Interleukin-6 Cytokines in Cancer Cachexia -- Chapter 7. NF-kB Signaling in the Macroenvironment of Cancer Cachexia -- Part III. Therapy-induced Muscle Wasting -- Chapter 8. Therapy-induced Toxicities Associated with the Onset of Cachexia -- Chapter 9. Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy -- Part IV. Preventing and Targeting Cachexia in Cancer -- Chapter 10. New Developments in Targeting Cancer Cachexia -- Chapter 11. Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer.

Description / Table of Contents: 1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies.

Description / Table of Contents: The tumor microenvironment: focus on extracellular matrix -- Keratan Sulphate in the Tumour Environment -- Hyaluronan in the tumor microenvironment -- Fibronectin in the tumor microenvironment -- Matrix metalloproteinases role in tumor microenvironment -- Flipping the Molecular Switch: Influence of Perlecan and its Modifiers in the Tumor Microenvironment -- Heparan sulfate in the tumor microenvironment -- The role of Glypican-1 in the tumour microenvironment -- Index.

Description / Table of Contents: The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies -- Genomics and the Immune Landscape of Osteosarcoma -- RECQ DNA Helicases and Osteosarcoma -- Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma -- Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma -- Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response -- Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: 2019 update -- The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets -- Autophagy in OS -- Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs -- Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment -- Comparative Immunology and Immunotherapy of Canine Osteosarcoma -- Index.

Description / Table of Contents: Data Analysis of Infection Rates Among Exposed Healthcare Workers Could Reveal Effective Prophylactics Against SARS-CoV-2 -- Immune Responses to SARS-CoV, MERS-CoV AND SARS-CoV-2 -- Normothermic Preservation of Liver – What does the Future Hold? -- Tissues from Post-Mortem Donors as Alternative Sources of Stem Cells for Regenerative Medicine -- New Pioneers of Optogenetics in Neuroscience -- A Current Overview of Scaffold-Based Bone Regeneration Strategies with Dental Stem Cells -- The Importance of Stem Cell Senescence in Regenerative Medicine -- Hematological Malignancies and Fertility -- Unraveling polymeric nanoparticles cell uptake pathways: two decades working to understand nanoparticles journey to improve gene therapy -- Cellular Dust as a Novel Hope for Regenerative Cancer Medicine.

Description / Table of Contents: Apelin Receptor Signaling During Mesoderm Development -- Epidermal stem cells in regenerative medicine -- The cellular and molecular patterns involved in the neural differentiation of adipose-derived stem cells -- Biomatrices for heart regeneration and cardiac tissue modelling in vitro -- Dentin-Pulp Tissue Regeneration Approaches in Dentistry: An Overview and Current Trends -- Stem Cell Culture under Simulated Microgravity -- Smart Polymeric Systems: A Biomedical Viewpoint -- Acute lung injury: Disease modelling and the therapeutic potential of stem cells -- COVID-19 and Mesenchymal Stem Cell Treatment; Mystery or Not -- PCDH19 pathogenic variants in males: Expanding the phenotypic spectrum.

Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.

Description / Table of Contents: A historical and evolutionary view of tight junctions -- Tricellular tight junctions -- Mechanosensitivity of tight junctions -- Intracellular traffic and non-canonical roles of ZO-2 protein -- Impact of claudin-2 and occludin expression in inflammation disorders -- Tight junctions in the inflamed gut -- Intestinal barrier disruption by enteropathogenic Escherichia coli -- Tight junction barrier function regulation by microbiota -- Claudin-7 participation in cell-substrate adhesion, cell migration, salt balance in the renal collecting duct and gut cell renewal and differentiation -- Regulation of the alveolar epithelial barrier by claudin-5 -- Regulation of the blood-retinal barrier by occludin phosphorylation, norrin and sonic hedgehog signaling -- Transmigration of metastatic cells through the blood-brain barrier -- Endocytosis of tight junction proteins -- Regulated degradation of claudins. .

Description / Table of Contents: Preface -- Supercritical Fluid Technologies: A Green Solvent Approach for Pharmaceutical Product Development -- Supercritical Green Solvent for Amazonian Natural Resources -- Non-catalytic and catalytic supercritical water oxidation of phenol in the wastewaters of petroleum and other industries -- Production of Platform Chemicals using Supercritical Fluid Technology -- Supercritical carbon dioxide — a glimpse from the modern era of green chemistry -- Extraction of phenolic compounds by Supercritical fluid extraction -- The Application of Supercritical Carbon Dioxide in the Extraction of Biomolecules -- Chemistry of ionic liquid, switchable solvents, supercritical carbon dioxide and sub/supercritical water -- Applications of supercritical carbon dioxide in the rubber industry -- Compressed fluids for food by-products biorefinery -- Index.

Description / Table of Contents: Foreword -- Preface -- Accelerated Breeding of Plants: Methods and Applications -- Speed Breeding: Methods and Applications -- Genomic Selection in Cereal Crops: Methods and Applications -- Data Driven Decisions for Accelerated Plant Breeding -- Advanced Quantitative Genetics Technologies for Accelerating Plant Breeding -- Haploid Production Technology: Fasten Wheat Breeding to Meet Future Food Security -- Recent Advances in Chromosome Elimination Mediated Doubled Haploidy Breeding: Focus on Speed Breeding in Bread and Durum Wheats -- Acceleration of the Breeding Program for Winter Wheat -- Genomics, Biotechnology and Plant Breeding Towards Improving Rice Production -- High Frequency Androgenic Green Plant Regeneration in Indica Rice for Accelerated Breeding -- Doubled Haploid Technology for Rapid and Efficient Maize Breeding -- Bio-fortification of Maize using Accelerated Breeding Tools -- Efficient Barley Breeding -- Finger Millet (Eleusine coracana L. Gaertn.) Genetics and Breeding for Rapid Genetic Gains -- Breeding Advancements in Barnyard Millet -- Sorghum Improvement Through Efficient Breeding Technologies -- Index.

Description / Table of Contents: Part I. Cancer -- Ubiquitin-Regulated Cell Proliferation and Cancer -- Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer -- The Proteasome System in Health and Disease -- Proteostasis Dysregulation in Pancreatic Cancer -- Divergent Modulation of Proteostasis in Prostate Cancer -- Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma -- Part II. Neurodegeneration -- Altered Proteostasis in Neurodegenerative Tauopathies -- The Ubiquitin System in Alzheimer’s Disease -- The Interplay Between Proteostasis Systems and Parkinson’s Disease -- Machado–Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides -- Part III. Infection, Inflammation and Developmental Disorders -- SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends -- The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication -- By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System -- TRIM E3 Ubiquitin Ligases in Rare Genetic Disorders -- Part IV. Diet -- We Are What We Eat: Ubiquitin–Proteasome System (UPS) Modulation Through Dietary Products.

Description / Table of Contents: Section I: Introduction -- Lessons learned from paleolithic models and evolution for human health: a snap shot on beneficial effects and risks of solar radiation -- Section II: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences (I) -- Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need? -- Section III: Solar radiation, Vitamin D and human health -- Vitamin D status and cancer incidence and mortality -- Vitamin D receptors polymorphisms and cancer -- On the relationship between sun exposure and all-cause mortality -- Lindqvist PG (2020) Women with greater sun exposure habits seem to be healthier and to live longer. Are these results in contrast to other research? No -- Section IV: Epidemiology of skin cancer -- Epidemiology of skin cancer and UV radiation – update 2019 -- Solar UV exposure and mortality from skin tumors: an update -- Solarium Use and Risk for Malignant Melanoma: many open questions,not the time to close the debate -- Section V: Photocarcinogenesis of skin cancer -- Molecular biology of basal and squamous cell carcinomas -- Human papillomaviruses and skin cancer -- The immune system and pathogenesis of melanoma and nonnmelanoma skin cancer -- Section VI: The relevance of the vitamin D endocrine system for skin cancer -- Protection from ultraviolet damage and photocarcinogenesis by vitamin D compounds -- The role of classical and novel forms of vitamin D in the pathogenesis and progression of non-melanoma skin cancers -- The Vitamin D Receptor as tumor suppressor in skin -- Cancer prevention in skin and other tissues via cross-talk between vitamin D- and p53- signalling -- Section VII: Prevention and Management of Skin Cancer -- Sunscreens in the United States: Current Status and Future Outlook -- A handful of sunscreen for whole body application -- Sunlight, vitamin D and Xeroderma pigmentosum -- Update: Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs) -- Section VIII: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences – II. promise and outlook -- Ultraviolet exposure scenarios: balancing risks of erythema and cutaneous vitamin D synthesis -- The Paleolithic nutrition model in relation to ultraviolet light and vitamin D -- Index.

Description / Table of Contents: 1. The BRCA1 and BRCA2 genes in early onset breast cancer patients -- 2. Anti-cancer effect of Xao tam phan Paramignya trimera methanol root extract on human breast cancer cell line MCF-7 in 3D model -- 3. A novel nonsense mutation c.374C〉G in CYP21A2 gene of a Vietnamese patient with congenital adrenal hyperplasia -- 4. Variation of Mitochondrial DNA HV1 AND HV2 of the Vietnamese Population -- 5. Synthesis and Characterization of PLGA-PEG Thymoquinone Nanoparticles and its Cytotoxicity Effects in Tamoxifen-resistant Breast Cancer Cells -- 6. Adipose-derived mesenchymal stem cells promote growth and migration of lung adenocarcinoma cancer cells -- 7. Predictive potential of PD-L1, TYMS and DCC expressions in treatment outcome of colorectal carcinoma -- 8. Clinical trials with cytokine-induced killer cells and CAR-T cell transplantation for non-small cell lung cancer treatment -- 9. Isopanduratin A isolated from Boesenbergia pandurata reduces HepG2 hepatocellular carcinoma cell proliferation in both monolayer and three-dimensional cultures -- 10. Hopea Odorata extract can efficiently kill breast cancer cells and cancer stem like cells in three-dimensional culture more than in monolayer cell culture -- 11. Selective cytotoxicity of some plant extracts against hepatocellular carcinoma cells but not mesenchymal stem cells: A pilot screening.

Description / Table of Contents: 1. An Introduction to Sri Lanka and its cinnamon industry -- 2. Historical, Ethno-botanical and Social Aspects of Cinnamon Cultivation in Sri Lanka -- 3. Ceylon Cinnamon Production and Markets -- 4. Botany of Endemic Cinnamomum species of Sri Lanka -- 5. Genetics and Molecular Characterization of Genus Cinnamomum -- 6. Germplasm Resources, Crop Improvement and Biotechnological Tools in aid of Cinnamon Breeding -- 7. Ecology, Agronomy and Management of Cinnamon (Cinnamomum zeylanicum Blume) -- 8.Pests and Diseases of Cinnamon (Cinnamomum zeylanicum Blume) -- 9. Cinnamon Process Technology -- 10. Chemistry and Bioactive Compounds of Cinnamomum zeylanicum Blume -- 11. Tapping into the potential of cinnamon as a therapeutic agent in neurological disorders and metabolic syndrome -- 12. Pharmacological Properties of Ceylon Cinnamon -- 13. Industrial applications of Ceylon Cinnamon (Cinnamonium zeylanicum Blume) as Nutraceuticals and Cosmeceuticals -- 14. Public-private partnership in growth and development of cinnamon industry in Sri Lanka -- 15. Value Creation and Food Products of Cinnamon -- 16. Cinnamon value chain dynamics and enhancement -- 17. Planning and Strategic Policy Interventions for Building a Globally Competitive Cinnamon Industry in Sri Lanka -- Index.

Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.

Description / Table of Contents: Introduction -- Porosome: Cells Secretory Nanomachine -- Ubiquitin-Proteasome Machinery: Cells Garbage Disposal -- Chaperonin: Protein Folding Machinery in Cells -- ATP Synthase: Energy Generator of the Cell -- Ribosome: Cells Protein Synthetic Machinery -- Nuclear Pore: A Bidirectional Transport Machinery -- Myosin: Cellular Molecular Motor -- Assembly of Cellular Nanomachines. Index.

Description / Table of Contents: Introduction (MCG and FN) -- Updates on ATMP regulations from EU: experience with PRIME procedure and list of approved ATMP -- EU portal for clinical trials application -- European Pharmacopoeia texts on gene therapy medicinal products -- Updates on ATMP regulations from UK after Brexit and list of approved ATMP -- Updates on ATMP regulations from Switzerland and list of approved ATMP -- Updates on ATMP regulations from US FDA: experience with breakthrough/accelerated procedures and list of approved ATMP -- Updates on ATMP regulations from Canada and list of approved ATMP -- Updates on ATMP regulations from Brasil and list of approved ATMP -- Updates on ATMP regulations from Singapore and list of approved ATMP -- Updates on ATMP regulations from Japan: experience with new law and list of approved ATMP -- Updates on ATMP regulations from South Korea and list of approved ATMP -- Updates on ATMP regulations from Taiwan and list of approved ATMP -- Updates on ATMP regulations from Thailand and list of approved ATMP -- ATMP regulations in China and list of approved ATMP -- ATMP regulations in Australia and list of approved ATMP -- ATMP regulations in India and list of approved ATMP -- International harmonization programs. .

Description / Table of Contents: The Art of Cell Therapy -- Scope and Applicability of Autologous Cell Therapies -- Scale and Accessibility of Allogeneic Cell Therapies -- Acellular Stem Cell Products. Potency Assays: The Buggy Boo of Stem Cell Therapy -- Potency Assay Development: A Keystone for Clinical Use -- Quantifying Critical Quality Attributes -- Advanced Technologies for Potency Assay Measurement -- Potency Quality by Design: Tailoring for Specific Therapy -- Contract Research Organizations Expediting Therapeutic Availability -- Regulatory Authority Perspectives for Potency Release Criteria -- Illustrative Potency Assay Examples from Approved Therapies -- The Integrity of Potency Assays and Safe Intervention -- The Evolving Landscape of Potency Assays.

Description / Table of Contents: Part 1: Functions of Macropinocytosis -- Chapter 1: Functional Diversity of Macropinocytosis -- Chapter 2: Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways -- Chapter 3: The amoebal model for micropinocytosis -- Chapter 4: Extracellular ATP and macropinocytosis -- Chapter 5: Macropinocytosis and Cell Migration: Don't drink an drive -- Chapter 6: Macropinocytosis in phagocyte function and immunity -- Part 2: Signaling Mechanisms Driving Macropinocytosis -- Chapter 7: Roles of 3' Phosphoinositides in Macropinocytosis -- Chapter 8: Signaling pathways that regulate macropinocytosis in mammalian cells -- Chapter 9: Wnt, GSK3 and Macropinocytosis -- Chapter 10: Kras addiction promotes cancer cell adapation in harsh microenvironment through micropinocytosis -- Chapter 11: Kras-independent macropinocytosis in pancreatic cancer.

Description / Table of Contents: Chapter 1. The hope and the hype in organoid technology in regenerative medicine (Badrul Hisham Yahaya) -- Chapter 2. Pluripotent stem cell derived and adult-tissue-derived organoid (Tiago G. Fernandes) -- Chapter 3. Generation of human organoid for 3D stem cell culture Hans Clevers -- Chapter 4. Organogenesis in a dish: Organ developmental study using organoid technology (Kursad Tuksen) -- Chapter 5. Disease modelling using patient-derived organoid (Narisorn Kitiyanant) -- Chapter 6. Tumor organoid as a model to study cancer microenvironment (Ahmad Faried) -- Chapter 7. Gene-editing in organoid to improve understanding of human disease (Yinming Liang) -- Chapter 8. Organoid culture as a good model to study lung development (Mitsuru Morimoto) -- Chapter 9. Organoid as good model for respiratory diseases (Badrul Hisham Yahaya).-Chapter 10. In vitro 3D model on reproductive system (Ruttachuk Rungsiwiwut) -- Chapter 11. Modelling of neuronal organoid: The way forward and challenges (Juntang Lin) -- Chapter 12. Generation of cardiac organoid in early heart organogenesis (Tan Jun Jie) -- Chapter 13. Neural Crest-Derived Stem Cells in organoid development for neurodegenerative disease modelling (Darius Widera) -- Chapter 14. Organoid for drug discovery and personalized treatment (Toshio Takahashi) -- Chapter 15. Ethical concern on patient-derived organoid (Phuc Van Pham).

Description / Table of Contents: Part 1: Nutritional and Pharmaceuticals Properties -- Chapter 1. Date Palm: Source of Foods, Sweets and Beverages -- Chapter 2. Date Palm Bioactive Compounds: Nutraceuticals, Functional Nutrients and Pharmaceuticals -- Chapter 3. Green Synthesis of Nanoparticles from Date Palm (Phoenix dactylifera L.) -- Part 2: Omics Technologies -- Chapter 4. Omics Resources and Applications in Date Palm -- Chapter 5. Proteomic Insights of Date Palm Embryogenesis and Responses to Environmental Stress -- Chapter 6. Date Palm Metabolomics -- Part 3: Molecular Breeding and Genome Modification -- Chapter 7. Induced Mutagenesis in Date Palm (Phoenix dactylifera L.) Breeding -- Chapter 8. Date Palm Quantitative Trait Loci -- Chapter 9. CRISPR-Cas Based Precision Breeding in Date Palm: Future Applications -- Part 4: Genomics of Abiotic and Biotic Stress -- Chapter 10. Metagenomics of Beneficial Microbes in Abiotic Stress Tolerance of Date Palm -- Chapter 11. Genomics Approaches for Insect Control and Insecticide Resistance Development in Date Palm.

Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.

Description / Table of Contents: Section 1: Genetic and Molecular Pathways of Cancer Growth and Metastasis -- Chapter 1. Hallmarks of Cancer: Molecular Underpinnings -- Chapter 2. Unifying concept of genomic changes: The mutational landscape of cancers -- Chapter 3. Tumor Microenvironment: Coconspirator in Tumorigenesis -- Chapter 4. Hallmarks of Metastasis: Molecular Underpinnings -- Chapter 5. Hereditary Cancer Syndromes and Cancer Metastasis -- Section 2: Pathology of Cancer Growth and Metastasis -- Chapter 6. Pathologic Assessment of Lymph Node Metastasis -- Chapter 7. Pathologic Assessment of Systemic or Distant Metastasis -- Chapter 8. The Role of Angiotropic Extravascular Migratory Metastasis in Metastases -- Section 3: Dormant Cancer Cells and their Reactivation in the Host Cancer Microenvironment -- Chapter 9. Tumor Dormancy and Relapse Regulated by the Extracellular Matrix -- Chapter 10. Therapy-Induced Dormancy and Residual Disease -- Section 4: The Microenvironment of Site-Specific Metastasis - Isaac P. Witz -- Chapter 11. The Microenvironment of Site-Specific Metastasis -- Section 5: Circulating Cancer Cells and Liquid Biopsy -- Chapter 12. Circulating tumor cells and ctDNA in sarcomas -- Chapter 13. Liquid biopsy using cell-free tumor DNA for gastrointestinal cancers -- Chapter 14. Circulating tumor cells and ctDNA in prostate cancer.-Chapter 15. Circulating Tumor Cells in Lung Cancer -- Chapter 16. CTCs/ ctDNA and Brain Metastasis.-Chapter 17. Epigenetics and liquid biopsy in oncology: role in metastasis and clinical utility -- Chapter 18. Metabolic reprogramming of circulating tumor cells for metastasis -- Section 6: Lymphatic System and Cancer Metastasis -- Chapter 19. Lymphatic System Biology, Pathobiology, and Relation to Cancer Metastasis -- Chapter 20. Lymphatic Specification and Development, EMT-MET, and Cancer Spread -- Chapter 21. Lymphangiogenesis, Lymph Nodes, Cancer Lymphangiogenesis and Metastasis -- Chapter 22. Immune cell trafficking in the lymphatics, hyaluronan biology and tumour metastasis -- Chapter 23. Lymphvascular Genomics and Proteomics, Clinical Syndromes, and Cancer Metastasis -- Chapter 24. Imaging of the Lymphatic System with Relevance to Cancer and Cancer Metastasis -- Chapter 25. Lymphedema: general pathophysiology, prevention and management in invasive cancer -- Section 7: Radiological Imaging of Early Cancer and Cancer Metastases -- Chapter 26. Primary Tumor Staging and Detection of Common Sites of Distant Metastatic Disease -- Chapter 27. Imaging Modalities in the Detection and Diagnosis of Metastatic Disease -- Chapter 28. Imaging of Bone Metastases -- Chapter 29. Imaging of Lung and Soft Tissue Metastases -- Chapter 30. Image-Guided Biopsy and Intervention for Metastatic Disease -- Section 8: Sentinel Lymph Node Surgery for Solid Cancer. Chapter 31. Sentinel Lymph Node Biopsy for Primary Cutaneous Malignancy -- Chapter 32. Sentinel Lymph Node Biopsy in Breast Cancer -- Chapter 33. Sentinel node navigation surgery for upper gastrointestinal cancer -- Chapter 34. Sentinel Lymph Node Mapping in Non-Small Cell Lung, Colon, and Thyroid Carcinomas -- Section 9: Surgical Treatment of Primary and Metastatic Cancer -- Chapter 35. The efficacy and evolution of surgical management based on cancer biology -- Chapter 36. The role of surgery in managing primary and metastatic melanoma -- Chapter 37. The Role of Surgery in Managing Primary and Metastatic Breast Cancer -- Chapter 38. The role of surgery in managing primary and metastatic colorectal cancer -- Chapter 39. The Role of Surgery in Management of Gastric Cancer -- Chapter 40. The role of surgery in managing primary and metastatic hepatopancreaticobiliary cancers -- Section 10: Cancer Metastasis to the Lung -- Chapter 41. Metastatic disease of the lung -- Section 11: Cancer Metastasis to the Liver -- Chapter 42. Tumor Resection and Ablation as a Means of Controlling Hepatic Metastases -- Chapter 43. Regional Arterial Infusional Therapy as a Means of Controlling Hepatic Metastases -- Section 12: Cancer Metastasis to the Bone -- Chapter 44. Molecular Mechanisms of Metastasis to the Bone.-Chapter 45. Surgical Management of Metastatic Disease to the Upper Extremity -- Chapter 46. Surgical Management of Metastatic Disease to the Lower Extremity -- Chapter 47. Surgical management of metastatic disease to the pelvis -- Chapter 48. Surgical Management of Metastatic Disease to the Spine -- Chapter 49. Interventional radiology techniques for management of skeletal metastases -- Section 13: Cancer Metastasis to the Brain and the Nervous System -- Chapter 50. Brain Metastases: Overview and Molecular Mechanisms -- Chapter 51. Indications and Techniques for Surgical Intervention in Patients with Metastatic Brain Tumors -- Chapter 52. Brain Metastases: Current and Future pharmacological treatment -- Chapter 53. Radiotherapy for CNS Metastases -- Chapter 54. Leptomeningeal Carcinomatoses -- Section 14: Urologic Cancer and 1st Patterns of Metastasis -- Chapter 55. Urologic Cancer and 1st Patterns of Metastasis -- Section 15: Biology and Clinical Aspects of Sarcoma Progression -- Chapter 56. Soft Tissue Sarcoma -- Chapter 57. Bone Sarcoma -- Chapter 58. Liposarcoma Metastasis -- Chapter 59. Desmoid Tumors.-Chapter 60. Atypical patterns of metastases: How do Sarcoma’s metastasize? -- Chapter 61. Tumor Immune Microenvironment of Soft Tissue Sarcoma -- Section 16: The Role of Radiation in the Treatment of Primary and Metastatic Cancer -- Chapter 62. Basic Principles of Radiobiology and Cancer Metastasis Prevention -- Chapter 63. Technical Innovations in the Delivery of Radiation Therapy -- Chapter 64. Radiation Therapy in the Definitive Treatment of Cancer -- Chapter 65. Radiation Therapy for Extracranial Oligometastatic Disease -- Chapter 66. Spine Radiotherapy -- Section 17: Immunotherapy of Solid Malignancies -- Chapter 67. Immunotherapy in Melanoma and Merkel Cell Cancer -- Chapter 68. Landscape of Immunotherapy in Lung Cancer -- Chapter 69. Immuno-oncologic Treatment of Genitourinary Malignancies -- Section 18: Current Topics -- Chapter 70. Personalized Systemic Cancer Therapy -- Chapter 71. Cancer Stem Cells and Their Role in Metastasis -- Chapter 72. HPV Induced Cancers -- Chapter 73. Microbiome and Cancer Metastasis -- Chapter 74. Application of Artificial Intelligence in Research on Cancer and Its Metastasis.

Description / Table of Contents: Brain Tissue Oxygen and BOLD fMRI Under Different Levels Of Neuronal Activity -- Cerebral Microcirculation and Oxygenation Modulation by Transcranial Alternating Current Stimulation in Awake and Anesthetized Mice -- The Effect of Hypercapnia on Cortical Metabolic Rate and Mitochondrial Redox Status -- Relationship Between Left-Right Dominancy of Prefrontal Cortex Activity and Heart Rate During Rest and Task Periods: An fNIRS Study -- Relationship Between Cognitive Function, Oral Conditions and Systemic Metabolic Function in the Elderly -- Pro-survival Phenotype of HIF-1α: Neuroprotection through Inflammatory Mechanisms -- Infradian Rhythms in Cerebrovascular Oxygenation and Blood Volume in Humans at Rest: A 5-year Study -- Mechanisms of Photostimulation of Brain’s Waste Disposal System: the Role of Singlet Oxygen -- Changes of Arterial and Venous Cerebral Blood Flow Correlation in Moderate-to-Severe Traumatic Brain Injury: A CT Perfusion Study -- Cerebral Net Water Uptake in Posttraumatic Cerebral Ischemia -- Brainstem Damage Underlies Changes in Hypoxic Ventilatory Response following Cardiac Arrest and Resuscitation in Rats -- Differences Between Good, Moderate and Poor Performers of a Verbal Fluency Task under Blue Light Exposure: An SPA-fNIRS Study -- Sex-specific and Dose-dependent Effects of Drag-Reducing Polymers on Microcirculation and Tissue Oxygenation in Rats after Traumatic Brain Injury -- Accuracy of Tissue Oxygen Saturation Measurements of a Textile-based NIRS Sensor -- Understanding the Role of Caveolae in Oxygen Buffering: The Effect of Membrane Curvature -- The Significance of Lipids for the Absorption and Release of Oxygen in Biological Organisms -- How Skin Color Depends on Tissue Oxygenation -- Tissue Concentration Analysis of Sulfur, Calcium and Oxygen in novel Skin Primo Nodes After Acupuncture -- Primo Vessels Inside Lymphatic Vessels are Absent in an ALS Mouse Model -- The Impact of Heterogeneous Cell Density in Hypoxic Tumors Treated with Radiotherapy -- A Critical Analysis of Possible Mechanisms for the Oxygen Effect in Radiation Therapy with FLASH -- Hyperhydration of Cancers: A Characteristic Biophysical Trait Strongly Increasing O2, CO2, Glucose and Lactate Diffusivities, and Improving Thermophysical Properties of Solid Malignancies -- No Difference in Muscle Basal Oxygenation in a Bedridden Population pre and Post Rehabilitation -- Relationship between Muscle Deoxygenation and Cardiac Output in Subjects without Attenuation of Deoxygenation Hemoglobin Concentration near the end of Ramp Cycling Exercise: A Longitudinal Study -- Image Reconstruction Using Deep Learning for Near-Infrared Optical Tomography: Generalization Assessment -- Neonatal Brain Temperature Monitoring Based on Broadband Near-Infrared Spectroscopy -- Time Domain Near-Infrared Optical Tomography Utilizing Full Temporal Data: A Simulation Study -- BIAN: A Multilayer Microfluidic-Based Tissue-Mimicking Phantom for Near-Infrared Imaging -- Do Vascular and Extracellular Measurements Consistently Reflect Intracellular pO2? Observation of Tissue Oxygenation Changes using Remote Photoplesysmography with a Smartphone -- Neurovascular, Metabolic, and Glymphatic Dynamics of the Brain Measured with fNIRS -- Imaging Cerebral Blood Vessels Using Near-Infrared Optical Tomography: A Simulation Study -- Reduced Cerebrovascular Oxygenation in Individuals with Post-Acute COVID-19 Syndrome (PACS) (“Long COVID”) -- Insufficient Oxygen Supplementation During Cardiopulmonary Resuscitation Leads to Unfavorable Biological Response While Hyperoxygenation Contributes to Metabolic Compensation -- Block of the Angiotensin Pathways Affects Flow-Volume Spirometry in Patients With SARS-CoV-2 Infection -- A Prospective Observational Pilot Study on the Effects of the Activity-based Stress Release Program on the Mental State and Autonomic Nervous System in Psychiatric patients. .

Description / Table of Contents: Molecular Mechanisms of SARS-CoV-2/COVID-19 Pathogenicity on the Central Nervous System: Bridging Experimental Probes to Clinical Evidence and Therapeutic Interventions -- The Probable Protective Effect of Photobiomodulation on the Inflammation of the Airway and Lung in COVID-19 Treatment: A Preclinical and Clinical Meta-Analysis -- Metabolomics Signatures of SARS-CoV-2 Infection -- Autophagic Mediators in Bone Marrow Niche Homeostasis -- Pluripotency Stemness and Cancer: More Questions than Answers -- In Vitro Culturing of Adult Stem Cells: The Importance of Serum and Atmospheric Oxygen -- Mouse Models of Asthma: Characteristics, Limitations and Future Perspectives on Clinical Translation -- From Cells to Organs: The Present and Future of Regenerative Medicine -- Tissue-Restricted Stem Cells as Starting Cell Source for Efficient Generation of Pluripotent Stem Cells: An Overview -- Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium.

Description / Table of Contents: Preface -- Mango: The King of Fruits -- Botanical descriptions -- Propagation practices -- Germplasm and genetic resources -- Genetic diversity analysis -- Alternate flowering -- Classical genetics and breeding -- In Vitro Culture and genetic transformation -- Molecular mapping and breeding in mango -- Genome sequence -- Sequencing of organellar genomes -- Functional genomics -- Genomic resources and database.

Description / Table of Contents: Climate-smart potato: An integrated breeding, genomics and phenomics approach -- Genomic designing for climate-smart tomato -- The importance of genetic and epigenetic research in the Brassica vegetables in the face of climate change -- Eggplant breeding and improvement for future climates.

Description / Table of Contents: Part 1: Biology and Phylogeny -- Chapter 1. Date Palm (Phoenix dactylifera L.) Biology and Utilization -- Chapter 2. Systematics and Evolution of the Genus Phoenix: Towards Understanding Date Palm Origins -- Chapter 3. A Brief History of the Origin of Domesticated Date Palms -- Part 2: Biodiversity and Molecular Identification -- Chapter 4. Genome Conformity of In Vitro Cultures of Date Palm -- Chapter 5.Date Palm Genetic Identification and Improvement Utilizing Molecular Markers and DNA Barcoding -- Chapter 6. DNA Fingerprinting of Date Palm Pollen Sources and their Relevance to Yield and Fruit Traits -- Chapter 7. Gender Determination of Date Palm -- Part 3: Genome Mapping and Bioinformatics -- Chapter 8. Whole Genome Mapping of Date Palm (Phoenix dactylifera L.) -- Chapter 9. Date Palm (Phoenix dactylifera L.) Chloroplast Genome -- Chapter 10. Comparative Analysis of Date Palm (Phoenix dactylifera L.) Mitochondrial Genomics -- Chapter 11. Date Palm Bioinformatics.

Description / Table of Contents: Metabolism in the tumor microenvironment -- Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment -- Viral hepatitis, inflammation, and tumour microenvironment -- Effects of HIV on the tumor microenvironment -- GLI2-mediated inflammation in the tumor microenvironment -- Stellate Cells in the Tumor Microenvironment -- Endothelial Progenitors in the Tumor microenvironment -- Chimeric antigen receptors for the tumour microenvironment -- Toll-Like Receptors (TLRs) in the Tumor Microenvironment (TME): A dragon-Like Weapon in a Non-Fantasy Game of Thrones -- Multiple dynamics in tumor microenvironment under radiotherapy -- Index.

Description / Table of Contents: Shaping of the tumor microenvironment by Notch signaling -- Erythropoietin signaling in the microenvironment of tumors and healthy tissues -- Neuropilin – handyman and power broker in the tumor microenvironment -- Translational landscape of mTOR signaling in integrating cues between cancer and tumor microenvironment -- Toll-like receptors signaling in the tumor microenvironment -- Rho-ROCK signaling in normal physiology and as a key player in shaping the tumor microenvironment -- S1P signaling in the tumor microenvironment -- CD200-CD200R pathway in the regulation of tumor immune microenvironment and immunotherapy -- Index.

Description / Table of Contents: Novel techniques to study the bone-tumor microenvironment -- An emerging model for cancer development from a tumor -- microenvironment perspective in mice and humans -- Effects of Exercise on the Tumour Microenvironment -- Effects of inhaled tobacco smoke on the pulmonary tumor microenvironment -- Multimodal molecular imaging of the tumour microenvironment -- Necrosis in the tumor microenvironment and its role in cancer recurrence -- The Multifaceted Effects of Autophagy on the Tumor Microenvironment -- The Sociobiology of Brain Tumors -- Tumor microenvironment conditioning by abortive lytic replication of oncogenic γ-herpesviruses -- The microbiome as a component of the tumor microenvironment -- Index.

Description / Table of Contents: Neutrophils in the Tumor Microenvironment -- Basophils in Tumor Microenvironment and Surroundings -- Janus or Hydra: The many faces of T helper cells in the human tumour microenvironment -- Cytotoxic CD8+ lymphocytes in the tumor microenvironment -- Mucosal-associated invariant T cells in tumors of epithelial origin -- Fibrocytes in the Tumor Microenvironment -- Models for Monocytic Cells in the Tumor Microenvironment -- Myeloid-Derived Suppressor Cells in the Tumor Microenvironment -- Index.

Description / Table of Contents: Adipocytes in the tumour microenvironment -- Fibroblasts in the tumor microenvironment -- Mesenchymal stem cells in the tumor microenvironment -- Hepatic stellate cells in liver tumor -- Pancreatic stellate cells: The key orchestrator of the pancreatic tumor microenvironment -- Endothelial cells in the tumor microenvironment -- Lymphatic endothelial cell progenitors in the tumor microenvironment -- Oligodendrocyte progenitors in the tumor microenvironment -- Index.

Description / Table of Contents: Preface -- PART 1: Basic Considerations -- Anatomy and Physiology of the Breast during Pregnancy and Lactation -- Diagnosis of Breast Disorders in Pregnancy and Lactation -- Clinical Presentations of Breast Disorders in Pregnancy and Lactation -- PART 2: Benign and Premalignant Disorders of the Breast in Pregnancy and Lactation -- Benign Disorders of the Breast in Pregnancy and Lactation -- Mastitis, Breast Abscess, and Granulomatous -- Premalignant disorders of the Breast in Pregnancy and Lactation -- PART 3: Breast Cancer in Pregnancy and Lactation -- Epidemiology of Pregnancy-Associated Breast Cancer -- Histology of Pregnancy-Associated Breast Cancer -- Clinical presentation, Diagnosis, and Prognosis of Pregnancy-Associated Breast Cancer -- . Treatment of Pregnancy-Associated Breast Cancer -- Special Clinical Situations -- Prenatal Care during and after Breast Cancer Treatment -- Lactation during and after Breast Cancer -- Pregnancy in Breast Cancer Survivors. Impact of Breast Cancer Treatment on Fertility -- Fertility Counseling and Preservation for Breast Cancer Patients -- Pregnancy after Breast Reconstruction -- Pregnancy and Lactation: Risk or Protective Factors for Breast Cancer -- Psychological Aspects of Pregnancy and Lactation in Patients with Breast Cancer.

Description / Table of Contents: Chapter 1. The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective -- Chapter 2. Circulating MicroRNAs as Cancer Biomarkers in Liquid Biopsies -- Chapter 3. Regulation of Immune Cells by MicroRNAs and MicroRNA-Based Cancer Immunotherapy -- Chapter 4. Machine-Learning-Based Methods and Best Practices of MicroRNA-Target Prediction and Validation -- Chapter 5. Turning Data to Knowledge: Online Tools, Databases and Resources in MicroRNA Research -- Chapter 6. Bioinformatics Methods for Modeling MicroRNA Regulatory Networks in Cancer -- Chapter 7. Analysis of the p53/MicroRNA Network in Cancer -- Chapter 8. Machine Learning Using Gene-Sets to Infer miRNA Function -- Chapter 9. miRNA:miRNA Interactions: A Novel Mode of miRNA Regulation and Its Effect on Disease -- Chapter 10. ClustMMRA v2: A Scalable Computational Pipeline for the Identification of MicroRNA Clusters Acting Cooperatively on Tumor Molecular Subgroups -- Chapter 11. 3D Modeling of Non-coding RNA Interactions.

Description / Table of Contents: Chapter 1. Mechanisms and biological roles of DNA methyltransferases and DNA methylation – from past achievements to future challenges -- Chapter 2.Bacterial DNA Methylation and Methylomes -- Chapter 3. ChapterDomain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases -- Chapter 4. Enzymology of Mammalian DNA Methyltransferases -- Chapter 5. Genetic Studies on Mammalian DNA Methyltransferase -- Chapter 6. Structure and Mechanism of Plant DNA Methyltransferases -- Chapter 7. DNA Methylation in Honey Bees and the Unresolved Questions in Insect Methylomics -- Chapter 8. N6-Methyladenine: A Conserved and Dynamic DNA Mark -- Chapter 9. Pathways of DNA Demethylation -- Chapter 10. Structure and Function of TET Enzymes -- Chapter 11.Proteins That Read DNA Methylation -- Chapter 12. Recent advances on DNA base flipping – a general mechanism for writing, reading, and erasing DNA modifications.-Chapter 13. The Role of DNA Methylation in Cancer -- Chapter 14. DNMTs and DNA damage -- Chapter 15. Role of DNMTs in brain -- Chapter 16. Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns.-Chapter 17. Inhibitors of DNA methylation -- Chapter 18. Rewriting DNA Methylation Signatures at Will: The Curable Genome Within Reach? -- Chapter 19. DNA Labeling Using DNA Methyltransferases.

Description / Table of Contents: Preface -- Introduction: Nanotechnology and Nanobiotechnology, Different Types of Nanomaterials, and General Characterization Techniques -- Microbial Synthesis of Different Nanomaterials using Prokaryotic Microorganisms (Bacteria and Actinomycetes) -- Microbial Synthesis of Different Nanomaterials using Prokaryotic Microorganisms (Bacteria and Actinomycetes) -- Photosynthesis of Different Nanomaterials Using Different Plant Extracts and the Extracts of Agro-Industrial Waste (Phytonanotechnology) -- Different Application Fields of Biologically Synthesized Nanoparticles -- Safety of Prepared Nanomaterials and Future Prospectives -- Bibliography -- Index.

Description / Table of Contents: Elastin in the Tumor Microenvironment -- Decorin in the tumor microenvironment -- Syndecan-1 in the tumor microenvironment -- Versican in the tumor microenvironment -- Chondroitin Sulphate Proteoglycans in the Tumour Microenvironment -- Lipoproteins and the Tumor Microenvironment -- The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility -- Thrombospondin in Tumor Microenvironment -- Tenascin-C function in glioma: immunomodulation and beyond -- Index.

Description / Table of Contents: Involvement of Endothelial Nitric Oxide Synthase in Cerebral Microcirculation and Oxygenation in Traumatic Brain Injury -- Imaging cerebral energy metabolism in healthy infants -- Changes in cerebral oxygenation and systemic physiology during a verbal fluency task: Differences between men and women -- Brain Tissue Conductivity in Focal Cerebral Ischemia -- Physical stress Attenuates Cognitive inhibition: An fNIRS Examination -- Changes in Prefrontal Cortical Oxygenation During Tilt Table Orthostatic Hypotension in Subarachnoid Haemorrhage Patients -- Effects of different optical properties of head tissues on near-infrared spectroscopy Using Monte Carlo Simulations -- Frontal cerebral oxygenation in humans at rest: A mirror symmetry in the correlation with cardiorespiratory activity -- Photomodulation of lymphatic delivery of bevacizumab to the brain: the role of singlet oxygen -- NIRS-based study of local cerebral oxygenation during transcranial direct current stimulation in patients with mild traumatic brain injury -- Postnatal Exposure to Brief Hypoxia Alters Brain VEGF Expression and Capillary Density in Adult Mice -- Impaired Cognitive Performance in Mice Exposed to Prolonged Hyperoxia -- Chronic Ketosis Modulates HIF1α-Mediated Inflammatory Response in Rat Brain -- Motor Imagery and Frontal Head Oxygenation: An fNIRS Study -- Non-invasive detection of persistent cortical hypoxia in Multiple Sclerosis using frequency domain near-infrared spectroscopy (fdNIRS) -- Evaluation of intraoperative end-tidal Carbon dioxide change relates to length hospitalization in peridiaphragmatic surgery: a pilot study -- Pulmonary Embolism in COVID-19 patients is not related to a worsening in tissue oxygenation -- Cardiovascular risk score and gas exchange in COVID-19 patients: no correlation -- Heme Oxygenase 1/ High Mobility Group Box 1 pathway may have a possible role in Covid-19 ARDS (Acute respiratory distress syndrome): a pilot histological study -- Silent Hypoxemia in COVID-19 pneumonia -- Low Flow and Microvascular Shunts: A Final Common Pathway to Cerebrovascular Disease: A Working Hypothesis -- A case of intracranial vertebral artery stenosis treated with percutaneous transluminal angioplasty and stenting guided by brain oximetry -- Assessment of Optimal Arterial Pressure with Near-Infrared Spectroscopy in Traumatic Brain Injury Patients -- Effects of exercise-diet therapy on cognitive function in healthy elderly people evaluated by deep learning based on basic blood test data -- NIRS studies show reduced interhemispheric functional connectivity in individuals with Multiple Sclerosis that exhibit cortical hypoxia -- Eye Tracking Parameters Correlate With the Level of Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Preliminary Study -- Critical closing pressure of cerebral circulation at concomitant moderate-to-severe traumatic brain injury -- Hybrid convolutional neural network (hCNN) for image reconstruction in near-infrared optical tomography -- Cross-frequency coupling between brain and body biosignals: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Machine learning distinguishes familiar from unfamiliar pairs of subjects performing an eye contact task: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Assessing Neurovascular Coupling Using Wavelet Coherence in Neonates With Asphyxia -- Basic examination of hemoglobin phase of oxygenation and deoxygenation in resting state and task periods in adults using fNIRS -- Development and validation of robust and cost-effective liquid heterogeneous phantom for time domain near-infrared optical tomography -- Effect of Exercise Therapy on Stress Response Evaluated by IoMT Monitoring System -- Improved optical tissue model for tissue oximetry imaging applications -- In vitro validation of a new tissue oximeter using visible light -- Photon and Proton Dose Painting based on Oxygen Distribution – Feasibility Study and Tumour Control Probability Assessment -- Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O2 Consumption of Tumour Cells -- Feasibility of non-invasive measurement of tumor NAD(H) by in vivo phosphorus-31 magnetic resonance spectroscopy -- Acidosis-induced regulation of Egr1 and Ccn1 in vitro and in experimental tumors in vivo -- Perfusion-Limited Hypoxia Determines the Outcome of Radiation Therapy of Hypoxic Tumours -- Improved Oxygenation of Human Skin, Subcutis and Superficial Cancers upon Mild Hyperthermia Delivered by wIRA-Irradiation -- Blood Supply and Oxygenation Status of the Liver: From Physiology to Malignancy -- Optical Redox Imaging Is Responsive to TGFβ Receptor Signaling in Triple-Negative Breast Cancer Cells -- Evaluation of betulinic acid derivatives as PET tracers for hypoxia-induced carbonic anhydrase IX (CA IX) expression -- Role of the mTOR signaling pathway during extracellular acidosis in tumor cells -- Feasibility Study of Remote Contactless Perfusion Imaging with Consumer-Grade Mobile Camera -- Stability of a Novel PEGylation site on a Putative Hemoglobin Based Oxygen Carrier -- Oxygen storage in stacked phospholipid membranes under an oxygen gradient as a model for myelin sheaths -- Confocal laser and electron microscopic investigation of gap junctions in anaplastic astrocytomas -- A radiation biological analysis of the oxygen effect as a possible mechanism in FLASH -- Assessment of nicotinamide adenine dinucleotide in human tissues by in vivo phosphorus-31 magnetic resonance spectroscopic imaging at 1.5 Tesla -- Drag-Reducing Polymers Improve Vascular Hemodynamics and Tissue Oxygen Supply in Mouse Model of Diabetes Mellitus -- Hemorheologic Enhancement of Cerebral Perfusion increases oxygen supply and reduces Ab plaques deposition in a mouse model of Alzheimer’s Disease -- Calorimetric Characterization of the Binding Reaction Between Human Ferric Hemoglobins and Haptoglobin to Develop a Drug for Removal of Cell-Free Haemoglobin -- Feasibility To Measure Tissue Oxygen Saturation Using Textile-integrated Polymer Optical Fibers -- Effect of Atorvastatin on Microcirculation Evaluated by Vascular Occlusion Test with Peripheral Near lnfrared Spectroscop -- Flow characteristics of the conjugate of anti-CD3 monoclonal antibodies and magnetic nanoparticle in the PBS and the blood vessel -- Cerebrovascular Reserve (CVR) and Stages of Hemodynamic Compromise -- On the mechanism of sustained mitochondrial membrane potential without functioning complex IV -- Further evidence that gradients of extracellular pH direct migration of MDA-MB-231 cells in vitro -- Blood Flow and Respiratory Gas Exchange in the Human Placenta at Term: A Data Update -- Oxyhaemoglobin Level Measured Using Near-Infrared Spectrometer is Associated with Brain Mitochondrial Dysfunction After Cardiac Arrest in Rats -- Changes in Oxygenation Levels During Moderate Altitude Simulation (Hypoxia-Induced): A Pilot Study Investigating the Impact of Skin Pigmentation in Pulse Oximetry -- The Intramuscular Circulation is Affected by Neck and Shoulder Pain -- Intramuscular circulation of the lumbar multifidus in different trunk positions on standing -- Numerical Optimization of a NIRS Device for Monitoring Tissue Oxygen Saturation -- Upper trapezius muscle tonicity, assessed by palpation, relates to change in tissue oxygenation and structure as measured by Time-Domain Near Infrared Spectroscopy -- Perceived exertion correlates with multiple physiological parameters during cardiopulmonary exercise testing -- Systemic and Quadriceps Muscle O2 Dynamics in Subjects without Attenuation Point of Deoxygenated Hemoglobin Concentration during Ramp Cycling Exercise -- Jaw-Clenching Intensity Effects on Masseter Oxygen Dynamics and Fatigue: A NIRS Oximetry Study. .

Description / Table of Contents: Overview of Basic Immunology and Clinical Application -- Advances in Diagnostic Procedures and their Applications in the era of Cancer Immunotherapy -- Immunotherapy for Melanoma -- Immunotherapy in Lung Cancer: From a minor God to the Olympus -- Immunotherapy in Gastrointestinal Malignancies -- Current Landscape of Immunotherapy in Genitourinary Malignancies -- Immuno-oncology for Gynecologic Malignancies -- Immunotherapy for Neuro-Oncology -- Immunotherapy and Radiation -- CAR T-cells -- Skin Reactions to Immune Checkpoint Inhibitors -- Gastrointestinal Tract Adverse Events -- Immune-Related Adverse Events: Pneumonitis -- Hepatobiliary Adverse Events -- Immune Checkpoint Inhibitors (ICIs) Related Cardiotoxicity -- Renal Toxicity -- Immune-Related Oral, Otologic and Ocular Adverse Events -- Cancer Imaging in Immunotherapy -- The Microbiome in Immuno-Oncology -- New developments in the use of Patient-reported outcomes in Cancer Patients undergoing Immunotherapies.

Description / Table of Contents: Preface -- Introduction – Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs -- Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis -- Disseminated Tumor Cells and Dormancy in Breast Cancer Progression -- Methodology for the Isolation and Analysis of CTCs -- Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-derived Models for Drug Testing -- Circulating Tumor Cells (CTCs) Heterogeneity in Metastatic Breast Cancer: Different Approaches for Different Needs -- Relevance of CTC Clusters in Breast Cancer Metastasis -- Epigenetics of Circulating Tumor Cells in Breast Cancer -- Circulating Tumor Cells: Applications for Early Breast Cancer -- Clinical Relevance and Therapeutic Application of CTCs in Advanced Breast Cancer. .

Description / Table of Contents: Preface -- New approaches for renewable energy using metal electrocatalysts for lithium-O2 and zinc-air batteries -- Biodiesel production for the sustainable development of chemical industry -- Cellulose based green and sustainable energy -- Design of dithienopyrrole-based organic dyes for efficient dye-sensitized solar cells: Strategies and outcome -- Sonochemical production of hydrogen: A novel approach -- Impact of alcohol and its blends on engine performance -- Photovoltaic performance of bipyridine and dipyridophenazine-based ruthenium complexes in application of dye-sensitized solar cell sensitizers -- Compressed fluids for food by-products biorefinery -- Green and sustainable biomass processing for fuels and chemicals -- Enriching of carotenes by supercritical desorption of buriti oil (Mauritia flexuosa Mart.) from alumina adsorbent -- Utilization of bio waste in green chemistry -- The role of heterogeneous catalysts in cellulose conversion to platform chemicals and biofuels -- Potential of neem oil as source of biodiesel -- Sustainable photocatalyst for energy and environment application -- Implementation guidelines for modelling gasification processes in computational fluid dynamics: A tutorial overview approach -- Sustainable cellulose based absorbents for heavy metal remediation -- Recent trend in photo-catalytic water of azo dyes -- Hospital effluents treatment -- Solar photocatalytic treatment of tannery effluent -- Modification of natural fibers by graft copolymerization and their environmental applications -- Dye degradation for environmental remediation -- Exploring natural coagulant application in the treatment of water for safe drinking -- Sustainable technologies for the wastewater treatment generated by leather industry sector: Regulation and economic aspects -- Physical and biological techniques to remediate carcinogenic Cr(VI) from industrial effluents -- Separation of industrial effluents -- Application of polymers in purification of industrial wastewater -- Role of disinfectants in green chemistry -- Sonochemistry in green processes: modeling, experiments and technology -- Biosynthesis of silymarin through plant in-vitro cultures -- Chemistry for new frontiers in supramolecular theranostics -- Cellulose nanocrystal aerogels: Synthesis, functional properties, and applications -- Graphene oxide: An efficient, and recyclable nano catalyst for the synthesis of 2-substituted benzimidazoles from aldehydes and diamines at ambient temperature -- Green synthesis of TiO2 nanomaterials photocatalyst -- Green corrosion inhibitors for industrial cleaning processes -- Cellulose amphiphilic materials: Chemistry, process, and applications -- Oleogels and their applications -- Measuring corrosion abrasion in various solid-fluid systems -- Base-free conversion of aldose sugar to aldonic acid -- Treatment of dairy products with conversion of useful bio-products -- Green corrosion inhibitor for petroleum pipelines -- Impact and challenges of polymerization -- Index.

Description / Table of Contents: Cathepsin D in the tumor microenvironment of breast and ovarian cancers -- Galectins in the tumor microenvironment: Focus on galectin-1 -- Iron in the tumor microenvironment -- Oxygen in the tumor microenvironment: mathematical and numerical modeling -- Roles for Phospholipase D1 in the tumor microenvironment -- Leptin in tumor microenvironment -- The immune consequences of lactate in the tumor microenvironment -- Fatty acid mediators in the tumor microenvironment -- Extracellular Vesicles in the tumor microenvironment: various implications in tumor progression -- Index.

Description / Table of Contents: Preface -- Introduction -- The intersection of anoikis resistance and fatty acid metabolism in cancer -- Anoikis resistance in melanoma -- Anoikis mediated by stress-activated MAPK signaling pathways -- Metabolic Regulation of Anoikis -- Metabolic Reprogramming contributes to Anoikis resistance in Cancer Cells -- Role of the nuclear receptors in anoikis -- The roles of anoikis in cervical cancer -- Shc and the control of small GTPase dynamics in cellular anchorage -- Anoikis and the Human Gut Epithelium in Health and Disease -- Epithelial cell extrusion: the prelude to anoikis -- Microtubule modifications and mitochondria: role in anoikis.

Description / Table of Contents: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.

Description / Table of Contents: Introduction to genome editing techniques: Implication in modern agriculture -- Application of bioinformatics tools in CRISPR/Cas -- CRISPR and food security: Application in cereal crops -- Improvement of floriculture crops using CRISPR/Cas and genome editing techniques -- Engineering crop plant resistance against abiotic stresses: CRISPR/Cas application and challenges -- Vegetable crop improvement using CRISPR/Cas -- Use of CRISPR/Cas in climate smart/resilient agriculture -- Intellectual Property Landscape on CRISPR/Cas.

Description / Table of Contents: Chapter 1: The Microbiome And The Hallmarks Of Cancer -- Chapter 2: Microbiome In Human GI Cancers -- Chapter 3: The Gut Microbiome And Colorectal Cancer -- Chapter 4: Salmonella Infection In Human Cancers -- Chapter 5: Biomarkers Of Esophageal Cancers And Precancerous Lesions -- Chapter 6: Epithelial And Immune Cell Responses To Helicobacter Pylori That Shape The Gastric Tumor Microenvironment -- Chapter 7: Microbiome And Liver Cancer -- Chapter 8: THE MICROBIOME AND UROLOGIC CANCERS -- Chapter 9: Role Of Infections And Tissue Inflammation In The Pathology Of The Fallopian Tube And High-Grade Serous Ovarian Cancer -- Chapter 10: Commensal Microbes And Their Metabolites: Influence On Host Pathways In Health And Disease -- Chapter 11: Dietary And Microbiome In Cancer Prevention -- Chapter 12: Autophagy And Cancer-Current Biology And Drug Development -- Chapter 13: Mitochondrial Regulation Of Inflammation In Cancer -- Chapter 14: Modern Germ-Free Study Designs And Emerging Static Housing Technology In A Growing ‘Human Microbiome’ Market -- Chapter 15: Machine Learning In Identification Of Disease-Associated Microbiota -- Chapter 16: Mediation Analysis Of Microbiome Data And Detection Of Causality In Microbiome Studies.

Description / Table of Contents: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.

Description / Table of Contents: Preface -- Nanomedicine: General Introduction from A to Z -- Immunology and Nanotechnology: Effects and Affects -- Role of Nanotechnology in Sensor Development -- Nanotechnology in the Characterization of Cancer -- Nano Vaccine -- Nanotechnology in Theranostics and In Vivo Imaging -- The Implication of Physical and Chemical Characterization of Therapeutic and Imaging Applications -- Polymers in Nanomedicine -- Delivery of Drug Payloads to Organs and Organ-Systems of Human Beings -- Drug Delivery Towards Cancer -- Drug Delivery Towards Malaria -- Nanotechnology in Tissue Engineering and Implant Development -- Interactions Between Nano-Delivery Agents and Immune Systems -- The Fate of Drug Delivery Agents after Delivery of Payload -- Index.

Description / Table of Contents: 1. Biophysiology of the uterus: development, cyclic changes, menopause -- 2. Hormonal effects in reproductive technology (ovulation stimulation, in vitro fertilization) -- 3. Hormonal role and therapy in common benign uterine lesions: endometrial polyps, leiomyomas, adenomyosis -- 4. Endometrial hyperplasia; precancerous lesions of the endometrium. Hormone therapy -- 5. Endometrial Carcinoma. Endometriosis, Hormonal Role in Carcinogenesis. Hormonal Therapy -- 6. Menopausal Hormone Therapy. Contraceptives -- 7. Replacement hormone therapy for gender dysphoria and congenital sexual anomalies -- 8. Hormone therapy for endometrial neoplasia related to breast cancer therapy (Tamoxifen) -- 9. Endometrial histopatholigic changes in hormonal therapy (contraceptives, ovulation stimulation, hormone replacement therapy, hormonal antitumoral therapy).

Description / Table of Contents: The Origin of Eukaryotic Cells and Multicellular Organisms -- Multicellular Organisms Propagation -- Grow Fast and Well or Die -- Why Do Animals Grow, Age and then Die? -- How Do Tissues Regenerate After an Injury? Epilog. The Future of Humankind Could Depend on Unicellular Life.

Description / Table of Contents: Chapter 1: Cash crops: An introduction -- Part I: Beverages -- Chapter 2: Cocoa -- Chapter 3: Coffee -- Part II: Industrial crops -- Chapter 4: Sugarcane -- Chapter 5: Rubber -- Chapter 6: Jute -- Part III: Oil seeds -- Chapter 7: Coconut -- Chapter 8: Oil Palm -- Chapter 9: Mustard -- Part IV: Pulses -- Chapter 10: Groundnut -- Chapter 11: Lentil -- Part V: Fruits and nuts -- Chapter 12: Date palm -- Chapter 13: Tomato -- Chapter 14: Cashewnut -- Part VI: Spices -- Chapter 15: Cardamom.

Description / Table of Contents: Recent Advances in the Generation of β-cells from Induced Pluripotent Stem Cells As a Potential Cure for Diabetes Mellitus -- Differentiated cells derived from hematopoietic stem cells and their applications in translational medicine -- Organoids in Tissue Transplantation -- Aldo keto reductases AKR1B1 and AKR1B10 in cancer: molecular mechanisms and signaling networks -- Bilayer Scaffolds for Interface Tissue Engineering and regenerative medicine: A Systematic Review -- Pluripotent Stem Cell Derived Neurons as In Vitro Models for Studying Autosomal Recessive Parkinson’s Disease (ARPD): PLA2G6 and Other Gene Loci -- Stem Cell Applications In Lysosomal Storage Disorders: Progress And Ongoing Challenges -- Mechanisms of Drug Resistance and Use of Nanoparticle Delivery to Overcome Resistance in Breast Cancers -- Telomere length and oxidative stress in patients with St-elevation and Non-St-elevation myocardial infarction -- Eosinophils as major player in Type 2 inflammation: autoimmunity and beyond.

Description / Table of Contents: 1.Challenges of Stem Cell Therapies for the Treatment of Infertility in Reproductive Medicine -- 2.Regeneration of Human Ovaries Through Mesenchymal Stem Cell Transplantation Is Becoming a Reality -- 3.In Vitro Activation of Follicles for Treatment of Ovarian Insufficiency -- 4.Ovarian Cancer Stem Cells and their Regulatory Mechanisms: Potential Targets -- 5.Ovarian Cancer Stem Cells: Approach to Individualized Medicine -- 6.New Insights in Spermatogonial Stem Cells -- 7.Spermatogonial Stem Cell Cryopreservation for Fertility Preservation -- 8.Endometrial Stem Cells and Endometriosis -- 9.Pathogenesis of Endometriosis: Are Endometrial Stem/Progenitor Cells Involved? -- 10.Stem Cell Transplantation for Endometrial Regeneration in Humans -- 11.Germinal Origin of Very Small Embryonic-like Stem Cells (VSELs): Relation to Primordial Germ Cells -- 12.The Role of Very Small Embryonic-like Stem Cells (VSELs) in Reproductive Tissues -- 13.Amniotic Membrane: A Unique Combination of Stem-Like Cells and Extracellular Matrix with Indispensable Potential for Regenerative Medicine -- 14.Human Umbilical Cord Blood Mesenchymal Stem Cell Transplantation in Kidney Injury Animal Models: a Critical Review -- 15.Stem Cells in Human Breast Milk and Neonate.

Description / Table of Contents: Preface -- Introduction -- Quantum Dots: Synthesis and Characterization -- Biochemical Effect of Quantum Dots on Plant Systems -- Functionalization of Quantum Dots -- Transport Mechanism from Quantum Dots to Plant Systems -- Graphene Quantum Dots -- Carbon Quantum Dots -- Quantum Dots for Sensing Microorganisms -- Potential Risks of Quantum Dots for Plant Systems -- Index.

Description / Table of Contents: Adjuvant and Neoadjuvant Chemotherapy for Osteosarcoma: A Historical Perspective -- Part 1: Surgical Considerations and Outcomes -- Limb Salvage and Reconstruction Options in Osteosarcoma -- Advances in the functional assessment of patients with sarcoma -- Part II: Novel Therapeutic Approaches Based on Biology -- Radiopharmaceuticals for Treatment of Osteosarcoma -- HER-2 Targeted Therapy in Osteosarcoma -- Aerosolized Chemotherapy for Osteosarcoma -- The Histone Deacetylase inhibitor Entinostat/Syndax 275 in Osteosarcoma -- Relapsed Osteosarcoma Trial Concepts to Match the Complexity of the Disease -- Using liquid biopsy in the treatment of patient with osteosarcoma -- Part III: Novel Immunotherapeutic Approaches -- Genetically modified T-cell therapy for osteosarcoma: into the roaring 2020’s -- Muramyl Tripeptide-Phosphatidyl Ethanolamine Encapsulated in Liposomes (L-MTP-PE) in the Treatment of Osteosarcoma -- Natural Killer Cell Immunotherapy for Osteosarcoma -- Nanocapsule delivery of IL-12 -- Discovery of cell surface vimentin (CSV) as a sarcoma target and development of CSV-targeted IL-12 immune therapy -- Part IV: Survivorship and Late Effects -- Editorial Comments on late effects -- Anthracycline-Induced Cardiotoxicity: Causes, mechanisms & prevention -- Exercise and Physical Activity in Patients with Osteosarcoma and Survivors -- Index.

Description / Table of Contents: Chapter 1. Chemoprevention of Cancer - Past,Present, and Future -- Chapter 2. Resveratrol for Cancer Prevention: Current Gaps and Opportunities -- Chapter 3. Pterostilbene as a Potent Chemopreventive Agent in Cancer -- Chapter 4. Pharmacokinetics and Bioavailability Enhancement of Natural Products -- Chapter 5. Vitamin D Compounds and Cancer Stem Cells in Cancer Prevention -- Chapter 6. Anti-cancer Effects of Silibinin – The Current Status in Cancer Chemoprevention -- Chapter 7. Adjuvant Value of Turmeric Extract (Containing Curcumin) in Colorectal Cancer Management -- Chapter 8. Cancer Prevention by Tea Polyphenols -- Chapter 9. The Chemopreventive Power of Isothiocyanates -- Chapter 10. Xanthohumol and Structurally Related Prenylflavonoids for Cancer Chemoprevention and Control -- Chapter 11. Anthocyanins and Cancer Prevention -- Chapter 12. Grape ChemopreventiveAgents AgainstAngiogenesis and Metastasis -- Chapter 13. Punicagranatum L. Constituents for Cancer Prevention, Chemosensitisation and Therapeutic Treatment -- Chapter 14. Cancer ChemopreventivePotential of Epidermal Growth Factor Receptor Inhibitors from Natural Products -- Chapter 15. Anti-cancer Dynamics of Natural Phytochemical Inhibitors of Cyclin-dependent Kinases -- Chapter 16. Pro-apoptotic Properties of Chemopreventive Agents -- Chapter 17. The Use of Anti-inflammatory Agents for Cancer Chemoprevention -- Chapter 18. Combination Chemoprevention by Targeting the Epigenome -- Chapter 19. Perspective – a positive cocktail effect of the bioactive components in the diet.

Description / Table of Contents: The future of stem cell research and its clinical translation in Canada: Exploring questions of governance and policy options -- Future cell and gene therapy for osteoarthritis (OA): potential for using mammalian protein production platforms, irradiated and transfected protein packaging cell lines for over-production of therapeutic proteins and growth factors -- The Horizon of Gene Therapy in Modern Medicine: Advances and Challenges -- Developments in Artificial Platelet and Erythroid Transfusion Products -- Advancing mesenchymal stem cell therapy with CRISPR/Cas9 for clinical trial studies -- Mesenchymal Stem Cells in Asthma -- Oocyte Aging: the Role of Cellular and Environmental Factors and Impact on Female Fertility -- Targeting Cancer Metabolism and Cell Cycle by Plant-derived Compounds -- Differentiation potential of Mesenchymal Stem Cells into Pancreatic β-Cells -- Zooming in across the Skin: A Macro-to-Molecular Panorama.

Description / Table of Contents: Introduction -- Assays for thiols and modifications -- Pitfalls of ROS measurements by fluorescent probes and mitochondrial superoxide determination using MitoSOX -- Methods and Reagents -- Clinical Probes for ROS and Oxidative Stress -- Measurement of oxidative stress markers in vitro using commercially available kits -- Oxidative Lipidomics - Analysis of Oxidized Lipids and Lipid Peroxidation in Biological Systems with Relevance to Health & Disease -- Clinically Related Models and Approaches -- Oxidant-Induced Models of Vascular Leak -- Ozone-Specific’ Oxysterols and Neuronal Cell Signaling -- Measurement Oxidative Stress Status in Human Populations: A Critical Need for a Metabolomic Approach -- Instrumental Methods -- Sense and Sensibility of Oxygen in Pathophysiology using EPR Oximetry -- Resonators for Clinical EPR -- Biomedical Overhauser Magnetic Resonance Imaging (OMRI). Noninvasive Imaging of Redox Processes -- Index.

Description / Table of Contents: The intestinal tumour microenvironment -- Gastric Tumor Microenvironment -- Parathyroid tumor microenvironment -- Microenvironment in Cardiac Tumor Development: What Lies Beyond the Event Horizon? -- The roles of bone marrow-resident cells as a microenvironment for bone metastasis -- Adipose tumor microenvironment -- Appendix Tumor Microenvironment -- Spinal cord tumor microenvironment -- Cancer stem cell niche and immune-active tumor microenvironment in testicular germ cell tumors -- Tumor microenvironment in skin carcinogenesis -- Index.

Description / Table of Contents: Preface -- Recent Advances in Electrochemical Sensor and Biosensors for Environmental Contaminants -- Research Insights on the Development of Biosensors -- Toxic Gas Sensors and Biosensors -- Biosensors Used for Monitoring Environmental Contaminants -- Screen Printed Electrochemical Sensors for Environmental Contaminants -- Sensors and Biosensors for Environmental Contaminants -- Green Synthesis of (Nano)Materials for (Bio)Sensing -- Green Synthesis of Plasmonic Metal Nanoparticles and Their Application of Environmental Contaminants -- Ionic Liquids Modified Sensors and Biosensors for Detection of Environmental Contaminants -- Nano-Biosensors for Detection of Phenolic Compounds -- Noble Metal: Metal Oxide Hybrid Nanoparticles for SERS-Based Sensors -- Molecularly Imprinted Nanosensors for Microbial Contaminants -- Nanomaterials as Toxic Gas Sensors and Biosensors -- Flexible Substrate-Based Sensors in Healthcare and Biosensing Applications -- Lab-On-A-Chip Devises for Water Quality Monitoring -- Advanced Nanostructure-Based Electrochemical Sensors for Pharmaceutical Drug Detection -- Green Sensors for Environmental Contaminants -- Bibliography -- Index.

Description / Table of Contents: Assays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis.

Description / Table of Contents: Preface -- Major Paradigm Shifts in Potato Breeding -- A Rapid Disease Resistance Breeding in Tomato (Solanum lycopersicum L.) -- Improvement of Onion through Accelerated Approaches -- Rapid Methods for Onion Breeding -- Accelerated Improvement of Cole Vegetable Crops -- Marker Assisted Selection in Pea Breeding -- Efficient Methods for the Improvement of Temperate Root Vegetables -- Rapid Methods of Improvement in Brinjal -- Conventional and Contemporary Approaches to Enhance Efficiency in Breeding Chilli/Hot Pepper -- Accelerated Breeding in Cucumber Using Genomic Approaches -- Advances in Improvement of Pumpkin and Squashes -- Accelerated Breeding in Okra -- New Initiatives in Quick Bitter Guard Breeding -- Principles and Techniques for Rapid Improvement of Muskmelon for Yield, Fruit Quality and Resistance to Biotic Stresses -- Accelerated Breeding of Cowpea [Vigna unguiculata (L.) Walp.] for Improved Yield and Pest Resistance -- Recent Trends in Sweet Pepper Breeding -- Index.

Description / Table of Contents: Chapter 1. General Principles -- Chapter 2. Signals – Scattering -- Chapter 3. Signals - Fluorescence, Phosphorescence, Impedance, Extinction -- Chapter 4. Fluidics -- Chapter 5. Light Sources -- Chapter 6. Optical Benches -- Chapter 7. Detectors and Electronics -- Chapter 8. Signal Analysis -- Chapter 9. The Cytometric File -- Chapter 10. Data Transformation -- Chapter 11. Data Representation -- Chapter 12. Data Analysis -- Chapter 13. Standards, Setup, Calibration, and Control Techniques -- Chapter 14. Fluorochromes – Overview -- Chapter 15. Fluorochromes Suitable for Antibody Conjugation -- Chapter 16. Fluorochromes That Bind Nucleic Acids -- Chapter 17. Fluorochromes for the Study of the Cell Features -- Chapter 18. Fluorescent Proteins -- Chapter 19. Spillover and Compensation -- Chapter 20. Artifacts -- Chapter 21. Cell Sorting -- Chapter 22. Non-Conventional Flow Cytometry -- Chapter 23. Statistics: A Cytometric Point of View.

Description / Table of Contents: IL-1 signaling in tumor microenvironment -- Interleukin-8 in the Tumor Immune Niche: Lessons from Comparative Oncology -- IL-9 and Th9 cells in tumor immunity -- IL-17 signaling in the tumor microenvironment -- Emerging roles for Interleukin-18 in the gastrointestinal tumor microenvironment -- IL-21 signaling in the tumor microenvironment -- ST2 signaling in the tumor microenvironment -- IL-36 Signaling in the Tumor Microenvironment -- Index.

Description / Table of Contents: Genomic Designing for New Climate-Resilient Almond Varieties -- Challenges and Strategies for Developing Climate-Smart Apple Varieties through Genomic Approaches -- Genomic Designing for New Climate-Resilient Apricot Varieties in a Warming Context -- Breeding Climate Resilient Bananas.

Description / Table of Contents: Eosinophils in the tumor microenvironment -- Dendritic cells in the tumor microenvironment -- Resident memory T cells in the tumor microenvironment -- NK cells in the tumor microenvironment -- γδ T cells in tumor microenvironment -- Regulatory T Cells in the Tumor Microenvironment -- The Hematopoietic Microenvironment in Myeloproliferative Neoplasms: The Interplay Between Nature (Stem Cells) and Nurture (the Niche) -- Langerhans cells in the tumor microenvironment -- Mast cells in the tumor microenvironment -- B cells in the gastrointestinal tumor microenvironment with a focus on pancreatic cancer: opportunities for precision medicine? -- Microglia in the Brain Tumor Microenvironment -- Index.

Description / Table of Contents: 1. NMR-Based Metabolomics in Cancer Research -- 2. Capillary Electrophoresis–Mass Spectrometry for Cancer Metabolomics -- 3. Chemical Isotope Labeling LC-MS for Metabolomics -- 4. Single cell metabolomics by mass spectrometry imaging -- 5. Fatty Acid Metabolism and Cancer -- 6. Metabolomics of Gastric Cancer -- 7. HIF-1α metabolic pathways in human cancer -- 8. Regulation of glycolysis in head and neck cancer -- 9. Metabolomics of oral/head and neck cancer -- 10. Ion chromatography with mass spectrometry for metabolomic analysis -- 11. Methods of lipidomic analysis: Extraction, derivatization, separation and identification of lipids -- 12. Functional metabolomics and chemoproteomics approaches reveal novel metabolic targets for anti-cancer therapy -- 13. Metabolomics of glioma -- 14. Microbial metabolomics: From methods to translational applications -- 15. Advances in the study of N6-methyladenine in eukaryotes -- 16. NMR Based Metabolomics -- 17. Quantitative analysis of oncometabolite 2-hydroxyglutarate -- 18. Tracer-based Cancer Metabolomic Analysis -- 19. Mass spectrometry-based shotgun lipidomics for cancer research -- 20. Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry-based Metabolomics.

Description / Table of Contents: Induced pluripotent stem cell derived human lung organoids to map and treat the SARS-CoV2 infections in vitro -- Embryonic Stem Cells in Clinical Trials: Current Overview of Developments and Challenges -- Functions of Mesenchymal Stem Cells in Cardiac Repair -- Cardiac Progenitor Cells -- Cardiac Immunology: a new era for immune cells in the heart -- Conventional and Alternative Mesenchymal Stem Cell Therapies for the Treatment of Diabetes -- Mesenchymal stem cells: The past present and future -- Extracellular vesicles therapeutics in regenerative medicine -- Exosomes as part of the human adipose-derived stem cells secretome- opening new perspectives for cell-free regenerative applications -- A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke.

Description / Table of Contents: Immune dysregulation and recurring mutations in myelodysplastic syndromes pathogenesis -- Stem Cell Aging and Regenerative Medicine -- Potential of Chimeric Antigen Receptor T-cells in cancer therapy -- Drug sensitivity and drug repurposing platform for cancer precision medicine -- Role and regulation of Lin28 in progenitor cells during central nervous system development -- Cartilage Repair by Mesenchymal Stem Cell-Derived Exosomes: Preclinical and Clinical Trial Update and Perspective -- Kaempferol induce cell death and sensitizes human head and neck squamous cell carcinoma cell lines to cisplatin -- A comprehensive approach to Urticaria: from clinical presentation to modern biological treatments through pathogenesis -- The potentials and pitfalls of using adult stem cells in cancer treatment -- The Outcome of Stem Cell-Based Therapies on the Immune Responses in Rheumatoid Arthritis.

Description / Table of Contents: 1. The role of targeted therapy in multiple myeloma -- 2. Lenalidomide -- 3. Pomalidomide -- 4. Mechanisms driving resistance to proteasome inhibitors bortezomib, carfilzomib and ixazomib in multiple myeloma -- 5. Daratumumab -- 6. Elotuzumab -- 7. Histone deacetylase inhibitors -- 8. Bone targeted therapies -- 9. New targeted therapies for multiple myeloma under clinical investigation.

Description / Table of Contents: Role of specific phytochemicals against gastrointestinal malignancies -- Role of phytochemicals on growth and metastasis of GI cancer -- Cancer Stem Cells as Therapeutic Targets for Gastrointestinal cancers -- Phytochemicals plus checkpoint inhibitors in GI cancers -- Crucial role of curcumin on gut microbiota associated with GI cancers -- Cellular and Molecular mechanisms of garlic compounds in common GI cancers -- Combination of Phytochemicals with Nanotechnology for Targeting GI Cancer Therapy -- Emerging Roles of Phytochemicals in the Pathobiology and Management of Esophageal Cancer -- Gastric Cancer: Role of Phytochemicals and Tyrosine Kinase Inhibitors -- Therapeutic Efects Of Curcumin Against Colorectal Cancer -- Molecular Pathways Involved in the Pathogenesis of Pancreatic Cancer: Role of Phytochemicals in Targeting the Clinical Outcomes -- Role of Dietary Supplementation of Natural products in the Prevention and Treatment of Liver Diseases -- Emerging Roles of Phytochemicals in Hepatocellular Carcinoma -- Phytochemicals: Current Understandings of the Modern Therapeutic Approaches for Hepatocellular Carcinoma -- Index.

Description / Table of Contents: Notch signaling in prevention ant therapy: fighting cancer with a two-sided sword -- Transcription factor RBPJ as a molecular switch in regulating the Notch response -- Unraveling of Hidden Secrets: The tumour suppressor Lethal (2) giant discs (Lgd)/CC2D1, Notch Signaling and Cancer -- Notch and endometrial cancer -- Notch and Esophageal Squamous Cell Carcinoma -- Notch signaling and liver cancer -- Notch inHead and Neck Cancer -- Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis -- The impact of Notch signalingfor carcinogenesis and progression of non-melanoma skin cancer: lessons learned fromcancer stem cells, tumor angiogenesis, and beyond -- Notch Signaling in Thyroid Cancer -- The Relevance of Notch Signaling in Cancer Progression -- Notch Signaling and the Breast Cancer Microenvironment -- Notch pathway: a journey from notching phenotypes to cancer immunotherapy -- Index.

Description / Table of Contents: Preface -- Genetic Resources of Medicinal and Aromatic Plants -- Analysis of Secondary Metabolites in Breeding Research and Plant Breeding -- Cannabis sativa L. - Cannabis -- Coriandrum sativum L. - Coriander -- Duboisia sp. – Corkwood Tree -- Lavandula angustifolia Mill. and Lavandula x intermedia Emeric ex Loisel - Lavender and Lavandin -- Matricaria recutita L. – True Chamomile -- Nasturtium officinale R.Br. - Watercress -- Nicotiana tabacum L. - Tobacco -- Ocimum basilicum L. - Basil -- Origanum majorana L. – Marjoram -- Origanum vulgare L. and Origanum onites L. – Oregano -- Petroselinum crispum (Mill.) Nyman - Parsley -- Rosa x damascena Mill. – Rose -- Rosmarinus officinalis L. - Rosemary -- Salvia officinalis L. and Salvia fruticosa Mill. – Dalmatian and Three-Lobed Sage -- Salvia sclarea L. – Clary Sage -- Thymus vulgaris L. – Thyme -- Valeriana officinalis L. s.l. – Valerian -- Zingiber officinale Roscoe - Ginger -- DNA content (C-values), chromosome numbers and mating system of medicinal, aromatic and stimulant plants -- Index.

Description / Table of Contents: In Vivo Optical Imaging and Manipulation of Brain Pericytes -- The complex and integral roles of pericytes within the neurovascular unit in health and disease -- Role of pericytes in brain metastasis -- Effects of Cytomegalovirus on Pericytes -- Pericytes in Retinal Ischemia -- Inflammatory mediators released by brain pericytes as sensors and effectors in blood-brain barrier dysfunction -- TLR-4 signaling in Pericytes -- EphA7+ Multipotent Pericytes and Their Roles in Multicellular Organisms -- Skeletal Muscle-Resident Pericyte Responses to Conditions of Use and Disuse -- Pericytes in myocardial diseases -- Adventitial and skeletal muscle pericytes in health and in ischemic tissue regeneration.

Description / Table of Contents: 1. Secondary Metabolite Production in Plant Cell Culture: A New Epigenetic Frontier -- 2. Plant Cell Biofactories as in vitro production platforms of the anti-cancer drug Camptothecin -- 3. Not One for All: The Interwoven Relationship Between Morphophysiology and Secondary Metabolite Production in Plant Cell Cultures -- 4. Anthocyanins and proanthocyanidins as Anti-cancer agents -- 5. Duckweeds for the production of therapeutic proteins -- 6. Essential oils from plants: Industrial applications and Biotechnological production -- 7. Biotechnological production of antistress compounds: Current status and future prospects -- 8. Elicitors as a biotechnological tool for in vitro production of bioactive phenolic compounds -- 9. Immobilization and Application of Industrial Enzymes on Plant Based New Generation Polymers -- 10. Recent advances towards development plant cell culture process for sustainable production of lignans and its health benefits -- 11. Physiology of camptothecin synthesis in plants and root organ cultures of Ophiorrhiza mungos L. and its production in root fermenters -- 12. In vitro culture of Haloxylon recurvum and Haloxylon salicornicum: valuable source of food additives, pharmaceutical and nutritional components from extreme arid zone.

Description / Table of Contents: Part 1: Knockouts and animal models -- Integrins α1β1 and α2β1 – The generalist collagen receptors -- Roles for Integrin α3β1 in Development and Disease -- Part 2: Fibrosis& Cancer -- Integrins: Key targets in tissue fibrosis and tumor stroma -- Integrins in Cardiac Form, Function and Disease -- Integrin 8 and its ligand nephronectin in health and disease -- v integrin-dependent TGF activation in cancer: a brief update -- Part 3: Human disease -- a11b1, a mesenchymal collagen-binding integrin with a central role in tissue- and tumor fibrosis -- Integrins in pathological tissue remodelling of joints -- α4 integrins in immune homeostasis and disease -- β2-integrins in immunity: new roles for old players -- Structure and function of the leukocyte integrin αMβ2 -- Part 4: Integrins in hemostasis, and immune control -- Platelet integrins: Critical mediators of haemostasis and pathological thrombus formation -- Integrins as receptors for bacterial and viral pathogens.

Description / Table of Contents: Chapter 1: Introduction to the collagen superfamily -- Chapter 2: Collagen IV-related disease -- Chapter 3: Articular collagens related diseases -- Chapter 4: Collagens as new players of nervous system disease -- Chapter 5: Collagens and EDS -- Chapter 6: Collagens and dystrophic epidermolysis bullosa -- Chapter 7: Collagen-related myopathies: pathogenic mechanisms and prospective therapies -- Chapter 8: Procollagen trafficking and its implicaitons in Osteogenesis Imperfecta.

Description / Table of Contents: The origin of cisgenesis, and its evolving definition -- Cisgenesis: enabling an innovative green agriculture by deploying genes from the breeders’ gene pool -- Cisgenesis and Intragenesis: innovative tool for crop improvement -- Cis Genesis of Crops -- Cisgenesis and plant breeding: A Review -- Opportunities for generic cisgenic crops -- Cisgenesis and Organic Farming -- Cisgenic Crops and Disease Resistance -- Cisgenesis and intragenesis as a biotechnological tool to improve abiotic stress tolerance in commercial crops -- DNA markers: an essential tool for cis-genic improvement of rice -- Cisgenic crops: major strategies to create cisgenic plants based on genome editing -- Cisgenesis in the era of genome editing and modern plant biotechnology -- The application of the bioinformatic, biotechnological, agronomic, and genetic improvement tools can help to develop plant species in less time, and with better characteristics.

Description / Table of Contents: Epithelial Stem Cells: Making, Shaping and Breaking the Niche -- Parathyroid Cell Differentiation from Progenitor Cells and Stem Cells: Development, Molecular Mechanism, Function, and Tissue Engineering -- Regenerative Medicine Application of Mesenchymal Stem -- Identification of Small Molecules That Enhance the Expansion of Mesenchymal Stem Cells Originating from Bone Marrow -- Human-Induced Pluripotent Stem Cell-Based Models for Studying Sex-Specific Differences in Neurodegenerative Diseases -- Current Status, Barriers, and Future Directions for Humanized Mouse Models to Evaluate Stem Cell-Based Islet Cell Transplant -- Mesenchymal Stem Cell Therapy for Osteoarthritis: Practice and Possible Promises -- The Historical Relationship Between Meis1 and Leukemia -- An Overview of Zebrafish Modeling Methods in Drug Discovery and Development -- Cellular Stress Responses in Oocytes: Molecular Changes and Clinical Implications.

Description / Table of Contents: 1.Extracellular Vesicle-associated Moonlighting Proteins: HSP and Metalloproteinases -- 2.Heat Shock Proteins and Periodontitis ― Crossreaction between Bacterial and Human HSP in Periodontal Infection Linking with Cardiovascular Diseases -- 3.Protective Role of Heat Shock Proteins during Neurodegeneration in Parkinson's Disease -- 4.HSP Stimulation on Macrophages and Dendritic Cells Activates Innate Immune System -- 5.Heat Shock Factor 1 and its Small Molecule Modulators with Therapeutic Potential -- 6.Heat Shock Proteins, a Key Modulator of Neuroinflammation in Alzheimer’s Disease -- 7.Role of Heat Shock Factor 1 in HIV -- 8.Heat Shock Protein and Cancer Based Therapies -- 9.Effects of Heat Shock Protein 70 kDa in Allergic Airway Inflammation -- 10.Role of Heat Shock Factor 1 in Neural Development and Disorders -- 11.Small Heat Shock Proteins in Inflammatory Diseases -- 12.Overview of Multifaceted Role and Significance of Heat Shock Proteins during Inflammation, Apoptosis and Other Diseases -- 13.Heat Shock Proteins as Target Autoantigens in Autoimmune Rheumatic Diseases -- 14.DNAJA3, a Co-chaperone in Development and Tumorigenesis -- 15.Therapeutic Potential of Heat Shock Proteins in Human Inflammation/Autoimmune Skin Diseases: Future Directions -- 16.Role of HSP in the Pathogenesis of Age-related Inflammatory Diseases -- 17.Heat Shock Factor Network in Kidney Diseases -- 18.Binary Role of Heat Shock Proteins in Cancer Immunotherapy: A Detailed Perspective -- 19.The role of heat shock proteins in reproductive functions -- 20.Heat shock proteins 70 in cellular stress: fight or flight -- 21.Indispensable role of protein turnover in autophagy, apoptosis and ubiquitination pathways -- 22.Heat Shock Proteins in Leishmania Parasites -- 23.HSF1 in RNA Polymerase II Promoter-Proximal Pausing and HSP70 Transcription -- 24.Induction of HSPA1A and Autophagy by SARS-CoV-2: Combined Potential Influence on Pregnancy Outcome.

Description / Table of Contents: 1. The Tumour Microenvironment and Circulating Tumour Cells: A partnership driving metastasis and glycan-based opportunities for cancer control -- 2. Dormancy in the Tumor Microenvironment -- 3. Tumor-associated tertiary lymphoid structures: A cancer biomarker and a target for next-generation immunotherapy -- 4. Studying the tumor microenvironment in zebrafish -- 5. Pre-metastatic niche formation by neutrophils in different organs -- 6. Tumor cell invasion and the tumor microenvironment: Special focus on brain tumors -- 7. The dog as a model to study the tumor microenvironment -- 8. EFFEROCYTOSIS AND THE STORY OF “FIND ME’’, ‘’EAT ME” AND “DON’T EAT ME” SIGNALING IN THE TUMOR MICRO ENVIRONMENT -- 9. Color-coded imaging of the tumor micro-environment (TME) in human patient-derived orthotopic xenograft (PDOX) mouse models -- 10. Mitochondria and the tumor microenvironment in blood cancer -- 11. Telocytes in the tumor microenvironment -- 12. Modeling the roles of astrocytes in the metastatic tumor cell microenvironment -- 13. Roles of fibroblasts in microenvironment formation associated with radiation-induced cancer -- 14. Tumor microenvironment-associated pericyte populations may impact therapeutic response in thyroid cancer -- 15. The adrenergic nerve network in cancer -- 16. Current treatment modalities targeting tumor microenvironment in castration-resistant prostate cancer -- 17.Brain metastases and tumor microenvironment -- 18. MIGRATION STIMULATING FACTOR (MSF). ITS ROLE IN THE TUMOUR -- MICROENVIRONMENT -- 19. Mechanical Signaling in the Mammary Microenvironment - from Homeostasis to Cancer -- 20. Osteopontin Signaling in Shaping Tumor Microenvironment Conducive to Malignant Progression -- 21. Progesterone receptor signaling in the breast tumor microenvironment -- 22. Progranulin/GP88, a complex and multi-faceted player of tumor growth by direct action and via the tumor microenvironmen -- 23. Sex-based differences in the tumor microenvironmet. .