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  • Bücher  (226)
  • E-Books: Biomedical and Life Sciences (AWI only)  (226)
  • Englisch  (226)
  • 580  (120)
  • 615  (105)
  • 550
  • 1
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Pharmacology. ; Cardiology. ; Therapeutics. ; Heart Surgery. ; Pharmacology. ; Cardiology. ; Therapeutics. ; Cardiac Surgery.
    Beschreibung / Inhaltsverzeichnis: Coronary Artery Disease: From Mechanism to Clinical Practice -- Evidence in guidelines for treatment of coronary artery disease -- Revascularization For Coronary Artery Disease: Principle And Challenges -- Antithrombotic drugs: pharmacology and perspectives -- Lipid modifying drugs: pharmacology and perspectives -- Anti-hypertensive drugs: pharmacology and perspectives -- Pharmaceutical treatment for Heart failure -- Drug discovery for coronary artery disease.
    Kurzfassung: This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.
    Materialart: Online-Ressource
    Seiten: IX, 339 p. 7 illus., 4 illus. in color. , online resource.
    Ausgabe: 1st ed. 2020.
    ISBN: 9789811525179
    Serie: Advances in Experimental Medicine and Biology, 1177
    DDC: 615
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Pharmacology. ; Pediatrics. ; Pharmacology. ; Pediatrics.
    Beschreibung / Inhaltsverzeichnis: Anti-epileptic drugs in pediatrics -- Current and new therapies for Duchenne Muscular Dystrophy -- Lysosomal diseases -- Mitochondriopathies -- Endocrinology thyroid, pituitary, growth stimulant, growth reduction -- Bone disease – bisphosphonates -- Diabetes type 1 and 3 (insulin; sulfonylurea; others) -- Diabetes type 2 (metformin etc.) -- Dermatology – part 1 urticaria, atopic dermatitis -- Dermatology part 2, ichtyosis, psoriasis -- Cardiovascular part 1- catcholamines, inotropic -- Cardiovascular part 2 – antiarhythmica, anti hypertensives -- Nephrology – dialysis -- How to use drugs in obese children and adolescents -- Haematology – CSFs, erythropoietin -- Antiretroviral/HIV -- Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life -- Antihelminth treatment -- Inflammatory bowel disease -- Constipation; laxatives -- Psychiatric diseases in children and adolescents -- Oncology – cell reducing agents part 1, part 2, part 3 -- Immunosuppressants – organ transplantation -- Bone marrow/stem cell transplantation -- Narcotic sparing approaches and the shift towards paracetamol in neonatal intensive care -- Disorders of puberty: pharmacotherapeutic strategies for management.
    Kurzfassung: This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.
    Materialart: Online-Ressource
    Seiten: VIII, 538 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2020.
    ISBN: 9783030504946
    Serie: Handbook of Experimental Pharmacology, 261
    DDC: 615
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Botany. ; Agriculture. ; Plant physiology. ; Plant Science. ; Agriculture. ; Plant Physiology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction to MAPs in the North America -- Chapter 2. Dr. Duke's Phytochemical and Ethnobotanical databases, a cornerstone in the validation of ethnoveterinary medicinal plants, as demonstrated by data on pets in British Columbia -- Chapter 3. Pharmacopoeial Wild Medicinal Plants of North America -- Chapter 4. Medicinal Plant Products, a Discussion of Actual or Probable versus Perceived Sources -- Chapter 5. Juniper species in North America to the same species in Europe with respect to phytochemistry and bioactivity -- Chapter 6. Mentha Genetic Diversity at the US National Clonal Germplasm Repository in Corvallis, Oregon -- Chapter 7. Advances in the research of basil -- Chapter 8. Advances in ther research of catnip -- Chapter 9. Diversity, conservation and sustainable harvest of medicinal plants in North America -- Chapter 10. The Great botanist, Jim Duke -- Chapter 11. TBC -- Chapter 12. Taxol or the story of the American yew -- Chapter 13. The Indian Tobacco -- Chapter 14. The American Elderberry -- Chapter 15. The American Ginseng.
    Kurzfassung: This volume is aimed at offering an insight into the present knowledge of the vast domain of Medicinal and Aromatic Plants with a focus on North America. In this era of global climate change the volume is meant to provide an important contribution to a better understanding of the diverse world of Medicinal and Aromatic Plant research, production and utilization.
    Materialart: Online-Ressource
    Seiten: VIII, 342 p. 59 illus., 24 illus. in color. , online resource.
    Ausgabe: 1st ed. 2020.
    ISBN: 9783030449308
    Serie: Medicinal and Aromatic Plants of the World, 6
    DDC: 580
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Botany. ; Plant genetics. ; Plant ecology. ; Plant Science. ; Plant Genetics. ; Plant Ecology.
    Beschreibung / Inhaltsverzeichnis: Preface -- Acknowledgement -- Chapter 1. Taxonomic History -- Chapter 2. Morphology -- Chapter 3. Biology -- Chapter 4. Economic Importance -- Chapter 5. Phylogeny, classification, and biogeography -- Chapter 6. Taxonomic revision -- Chapter 7. Conservation status.
    Kurzfassung: This book provides essential information on the morphology, biology, phytochemistry, pharmaceutical prospects, evolution, phylogeny, biogeography, and taxonomy of Paris (Melanthiaceae), a morphologically distinctive plant genus with great economic importance. Since the establishment of this genus, 70 species and 24 subspecific taxa have been described, resulting in considerable confusion in species delimitation. In this book, the taxonomy of all described taxa is carefully revised. Based on multi-disciplinary evidences, a revised classification system of Paris containing five sections is outlined. Every species is provided with a concise but diagnostic description, a color illustration, photographs that highlight distinguishing characters, examined specimens and distribution range. The interspecific relationships are clarified with an identification key. This monograph offers taxonomists, evolutionary biologists, ecologists, horticulturalists, phytochemists, and practitioners a thorough and up-to-date overview about this interesting plant group. It is equally valuable for undergraduate and graduate students, teachers and professionals engaged in related fields.
    Materialart: Online-Ressource
    Seiten: XIII, 203 p. 134 illus., 110 illus. in color. , online resource.
    Ausgabe: 1st ed. 2021.
    ISBN: 9789811579035
    DDC: 580
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Schlagwort(e): Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Beschreibung / Inhaltsverzeichnis: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Kurzfassung: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Materialart: Online-Ressource
    Seiten: VIII, 425 p. 70 illus. in color. , online resource.
    Ausgabe: 1st ed. 2021.
    ISBN: 9783030685102
    Serie: Handbook of Experimental Pharmacology, 264
    DDC: 615
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Botany. ; Botanical chemistry. ; Plant physiology. ; Agriculture. ; Plant Science. ; Plant Biochemistry. ; Plant Physiology. ; Agriculture.
    Beschreibung / Inhaltsverzeichnis: How the three organ-produced signals: auxin, cytokinin and gibberellin, induce and regulate wood formation and adaptation -- Role of plant growth regulators in the plant-environment interaction and epigenetic regulation of auxin -- The role of auxin and cytokinin signaling components in de novo shoot organogenesis -- Mechanism of crosstalk between cytokinin and gibberellin -- In vitro responses of some Mediterranean fruit crops to auxin, cytokinin and gibberellin treatments -- Integrative approach of the root architecture by interaction between auxin and nutrients -- Insights into Biosynthesis and Signaling of Cytokinins during Plant Growth, Development and Stress Tolerance -- Cytokinin signaling in plants under salt stress -- Auxin and Cytokinin Signaling in Plant Stress Response -- Gibberellins' cross talk and signal transduction in plant stress response -- Crosstalk between Salicylic acid and Auxins, Cytokinins and Gibberellins under biotic stress -- Understanding the crosstalk between chromatin remodeling mechanism and phytohormones signaling for maintenance of plant developmental plasticity: an insight -- Phytohormone-mediated regulation of sprouting in tuber and storage root crops -- Role of phytohormones in plant-microbial interaction -- Iron toxicity tolerance in rice: roles of auxins and gibberellins -- New auxin and cytokinin related compounds based on synthetic low molecular weight heterocycles.
    Kurzfassung: Plant hormones have pivotal roles in the regulation of plant growth, development, and reproduction. Their signaling pathways are interconnected in a complex network, which provides plants with an enormous regulatory potential to rapidly adapt to their environment and to utilize their limited resources for growth and survival in a cost-efficient manner. Auxin is a hormone molecule whose activity levels are most important for its regulatory roles during plant cell, organ, and tissue development. Therefore, the precise regulation of auxin levels is an essential mechanism to fine-tune the activity of this powerful hormone during plant growth and development. Likewise, cytokinins exhibit a wide range of physiological functions, including regulation of shoot and root apical meristems, stimulation of branching, vascular development, chloroplast differentiation, stabilization of the structure and function of the photosynthetic machinery, delay of senescence, stomata opening, and elevation of the sink strength and nutritional signaling. Moreover, gibberellins also regulate many aspects of plant growth and development including seed germination, stem elongation, leaf expansion, and flower and fruit development. The broad implication of gibberellins in plant development is strictly associated with tight regulation of their metabolism by multiple environmental and endogenous factors, ranging from light and temperature to other hormones including feedback control. Understanding the significant roles of these phytohormones in plant biology, the current subject has attracted the attention of scientists from across the globe. This comprehensive volume “Auxins, Cytokinins and Gibberellins Signaling in Plants” highlights the various prospects involved in the current scenario. The book comprises the chapters from diverse areas dealing with biotechnology, molecular biology, proteomics, genomics, metabolomics, etc.
    Materialart: Online-Ressource
    Seiten: IX, 377 p. 63 illus., 39 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031054273
    Serie: Signaling and Communication in Plants,
    DDC: 580
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Beschreibung / Inhaltsverzeichnis: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Kurzfassung: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Materialart: Online-Ressource
    Seiten: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Ausgabe: 1st ed. 2021.
    ISBN: 9783030700638
    Serie: Handbook of Experimental Pharmacology, 265
    DDC: 615
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Botany. ; Plant biotechnology. ; Pharmaceutical chemistry. ; Agriculture. ; Proteins . ; Plant Science. ; Plant Biotechnology. ; Pharmaceutics. ; Agriculture. ; Protein Biochemistry.
    Beschreibung / Inhaltsverzeichnis: Chapter. 1. Molecular Farming in Plants: Introduction and Applications -- Chapter. 2. Tools and Techniques Used in Plant Molecular Farming -- Chapter. 3. Production of plant natural products in heterologous microbial species -- Chapter. 4. Sustainable Manufacturing of Vaccines, Antibodies, and other Pharmaceuticals -- Chapter. 5. Limitations, Biosafety, ethics, regulatory issues in molecular farming in plants -- Chapter. 6. Conclusion and Perspectives.
    Kurzfassung: Molecular farming is a biotechnological approach that includes the genetic adjustment of agricultural products to create proteins and chemicals for profitable and pharmaceutical purposes. Plant molecular farming describes the manufacture of recombinant proteins and other biologically active product in plants. This approach depends on a genetic transformation of plants that can be accomplished by the methods of stable gene transfer, such as gene transfer to nuclei and chloroplasts, and unstable transfer methods like viral vectors. The requirement for recombinant proteins in terms of quality, quantity, and diversity is increasing exponentially This demand is traditionally met by recombinant protein construction technologies and the engineering of orthodox expression systems based on bacteria or mammalian cell cultures. However, majority of developing countries cannot afford the high costs of medicine derived from such existing methods. Hence, we need to produce not only the new drugs but also the cheaper versions of those already present in the market. Plant molecular farming is considered as a cost-effective technology that has grown and advanced tremendously over the past two decades. This book summarizes the advances and challenges of plant molecular farming for all those who are working on or have an interest in this rapidly emerging area of research.
    Materialart: Online-Ressource
    Seiten: IX, 77 p. 10 illus., 9 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031127946
    Serie: SpringerBriefs in Plant Science,
    DDC: 580
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Schlagwort(e): Botany. ; Forestry. ; Botanical chemistry. ; Biotic communities. ; Plant genetics. ; Plant physiology. ; Plant Science. ; Forestry. ; Plant Biochemistry. ; Ecosystems. ; Plant Genetics. ; Plant Physiology.
    Beschreibung / Inhaltsverzeichnis: 1. Nitrogen and Sulfur Metabolism in Microalgae and Plants: 50 Years of Research -- 2. Progress Toward Deep Sequencing-Based Discovery of Stress-Related MicroRNA in Plants and Available Bioinformatics Tools -- 3. Recent Advances in MS-Based Plant Proteomics: Proteomics Data Validation Through Integration with Other Classic and -Omics Approaches -- 4. Membrane Trafficking and Plant Signaling -- 5. Molecular Aspects of Iron Nutrition in Plants -- 6. Urea in Plants: Metabolic Aspects and Ecological Implications -- 7. Biosynthesis and Regulation of Secondary Cell Wall -- 8. Stress-Induced Microspore Embryogenesis in Crop Plants: Cell Totipotency Acquisition and Embryo Development -- 9. Potential of Microalgae Biomass for the Sustainable Production of Bio-commodities -- 10. Crassulacean Acid Metabolism and Its Role in Plant Acclimatization to Abiotic Stresses and Defence Against Pathogens -- 11. The Role of the Shikimate and the Phenylpropanoid Pathways in Root-Knot Nematode Infection -- 12. Functional Diversity of Photosynthesis, Plant-Species Diversity, and Habitat Diversity -- 13. When the Tree Let Us See the Forest: Systems Biology and Natural Variation Studies in Forest Species -- 14. The Ecological Importance of Winter in Temperate, Boreal, and Arctic Ecosystems in Times of Climate.
    Kurzfassung: With one volume each year, this series keeps scientists and advanced students informed of the latest developments and results in all areas of the plant sciences. The present volume includes reviews on plant physiology, biochemistry, genetics and genomics, forests, and ecosystems.
    Materialart: Online-Ressource
    Seiten: XIII, 399 p. 47 illus., 38 illus. in color. , online resource.
    Ausgabe: 1st ed. 2020.
    ISBN: 9783030363277
    Serie: Progress in Botany, 81
    DDC: 580
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human physiology. ; Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human Physiology.
    Beschreibung / Inhaltsverzeichnis: Successful Vaccines -- Immunogenicity and Immunodominance in Antibody Responses -- Immunogen Design -- Adjuvants -- Tools to screen vaccines -- Targeting glycans on human pathogens for vaccine design -- BnAbs and highly antigenically variable pathogens.
    Kurzfassung: Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine. .
    Materialart: Online-Ressource
    Seiten: VII, 180 p. 16 illus., 15 illus. in color. , online resource.
    Ausgabe: 1st ed. 2020.
    ISBN: 9783030580049
    Serie: Current Topics in Microbiology and Immunology, 428
    DDC: 615
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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