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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Processing and storage can cause changes and interactions in food components that have effects on nutritional value, organoleptic characteristics or even food safety. This book includes 19 research works showing important and interesting advances, as well as new approaches, in this research topic. Four articles are dedicated to studying the effect of canning conditions (filling media and some ingredients) on the diverse parameters of quality for fish and pet foods. Three articles are devoted to studying the effects of dehydration (pre-treatments and drying procedures). One article is dedicated to monitoring the elaboration of a fermented and dehydrated product (sausage) using a portable NIRS device. The ninth article of this book studies the effect of low-dose electron beam irradiation on cooking quality, moisture migration, and thermodynamics, as well as the digestion properties of the isolated starches in newly harvested and dried rice. The next contribution studies the use of different preservatives to avoid the formation of undesirable volatile organic compounds in stracciatella cheese. Another article examines the impact of source material, kibble size, temperature, and duration on the efficiency of the aqueous extraction of sugars and phenolics from carob kibbles by conventional heat-assisted (HAE) and ultrasound-assisted (UAE) methods. In two articles, marinating with different extracts, alone or combined with other seasoning/conditioning methods, was essayed to tenderize beef or to improve the sensory quality of chicken leg and breast meat. The effect of various cooking methods on the quality, structure, pasting, water distribution and protein oxidation of fish and meat-based snacks is studied in the fourteenth article. The last five articles are dedicated to the study of the effects of storage on several foods (olive oil, blueberry, beetroot and Atlantic mackerel).
    Schlagwort(e): Electron Beam Irradiation ; rice ; moisture ; physicochemical properties ; rabbiteye blueberry ; postharvest storage ; firmness ; aroma compounds ; off-odor ; dry-fermented sausages ; near infrared spectroscopy ; portable device ; PLS-DA ; Scomber colias ; prior chilling ; Fucus spiralis ; packaging medium ; canning ; lipid damage ; colour ; trimethylamine ; quality ; carob kibbles ; carob juice ; aqueous extraction ; sugars ; phenolics ; free amino acids ; biogenic amines ; filling medium ; European eels ; stracciatella cheese ; volatile organic compounds ; sensory characteristics ; natural preservatives ; cheese storage ; pineapple by-products ; hydrostatic pressure ; bromelain ; enzyme activity ; marinade ; meat ; texture ; water status and distribution ; microstructure ; secondary structure of protein ; Atlantic mackerel ; saffron quality ; secondary metabolites ; drying ; high performance liquid chromatography-diode array detection (HPLC-DAD) ; spectrophotometry ; canned eels ; olive oil ; sunflower oil ; oxidation ; antioxidants ; total phenols ; vitamin E ; fresh wet noodles ; humidity-controlled dehydration ; microorganisms ; shelf-life ; noodle quality ; “Rocha” pear ; ultrasound ; microwave ; quality characteristics ; empirical models ; beetroot ; organic farming ; storage ; bioactive compounds ; betalain ; nitrate ; sugar ; phenolic compounds ; total dry matter ; chicken meat ; sensory evaluation ; superheated steam ; marination ; hot smoking ; storage effect ; extra virgin olive oil ; phenols ; sterols ; tocopherols ; temperature ; argon ; freeze-thaw cycles ; anthocyanins ; gas chromatography-mass spectrometry ; aroma profiles ; hot-air drying ; blueberry ; cooking methods ; fish meat snacks ; LF-NMR ; SEM ; protein oxidation ; expressible moisture ; gel ; gum ; heat penetration ; thermally processed ; wet pet food ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: This book is motivated by our passion to compile recent research on antimicrobial surfaces. We aimed to assemble research papers on the preparation of new materials, antimicrobial testing using different pathogens (bacteria, fungi, and viruses), and the relationship between the coating nanostructure and its reactivity towards the studied pathogen(s). We believe that a good antimicrobial coating should by characterized by (i) a fast activity towards the pathogen, (ii) sustainable activity based on the stability of the coating, and (iii) the lowest possible toxicity for humans and reduced risks for the environment. Striking a compromise between these different challenges is difficult and requires more research.
    Schlagwort(e): active packaging ; chitosan ; methylcellulose ; natamycin ; antimicrobial action ; quaternary ammonium groups ; acrylic acid ; glycidyl methacrylate ; crosslinking reaction ; coating ; edible films ; edible coatings ; antimicrobial agents ; fresh fish ; spoilage ; shelf-life ; black anther disease ; orchid cut flower ; silver nanoparticles ; antifouling efficacy ; flow-through ; triangular box ; Amphibalanus amphitrite ; cuprous oxide ; dynamic aging ; repellant activity ; raft experiment ; bioassay ; biofouling of ships’ hull ; polypropylene ; hernia meshes ; antibacterial ; drug release ; polydopamine ; antimicrobial ; citric acid ; cross-linked ; cold plasma ; antimicrobial activity ; brilliant green ; crystal violet ; demethylation ; lignin ; polyurethane coatings ; triphenylmethane dyes ; 3D printing ; catheters ; dialysis ; extrusion ; infections ; manufacturing ; infection ; coatings ; silver ; nanomaterials ; plasma deposition ; titanium-based thin films ; copper ; magnetron sputtering ; super-elastic coatings ; E. coli inactivation ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Anthropogenic and natural disturbances to freshwater quantity and quality are a greater issue for society than ever before. To successfully restore water resources requires understanding the interactions between hydrology, climate, land use, water quality, ecology, and social and economic pressures. This Special Issue of Water includes cutting edge research broadly addressing investigative areas related to experimental study designs and modeling, freshwater pollutants of concern, and human dimensions of water use and management. Results demonstrate the immense, globally transferable value of the experimental watershed approach, the relevance and critical importance of current integrated studies of pollutants of concern, and the imperative to include human sociological and economic processes in water resources investigations. In spite of the latest progress, as demonstrated in this Special Issue, managers remain insufficiently informed to make the best water resource decisions amidst combined influences of land use change, rapid ongoing human population growth, and changing environmental conditions. There is, thus, a persistent need for further advancements in integrated and interdisciplinary research to improve the scientific understanding, management, and future sustainability of water resources.
    Schlagwort(e): physical habitat ; aquatic ecology ; stream health ; environmental flows ; land use ; hydrology ; hydroecology ; ecohydrology ; climate change ; Appalachia ; reforestation ; land use-land cover ; land-atmosphere coupling ; water quality ; environmental perceptions ; human dimensions ; spatial models ; socioeconomics ; urban watershed management ; municipal watershed ; water quality impairment ; collaborative adaptive management ; water resources ; urban watersheds ; endocrine disrupting chemical ; opioid ; pathway analysis ; ontology ; metabolomics ; decision-making ; logit regression ; farmer perceptions ; social networks ; public funds ; water conservation adoption ; good governance ; sanitation ; sustainability ; water supply ; water-saving agriculture ; Chinese provincial input efficiency ; three-stage DEA model ; environmental variables ; Boufakrane river watershed ; remote sensing ; LULCC ; water balances ; vulnerability ; total dissolved solids ; drinking water ; Appalachian Mountains ; streamflow sensitivity ; water security ; water balance partitioning ; Budyko ; Escherichia coli ; Suspended particulate matter ; Water quality ; Land use practices ; Watershed management ; basin ; hydrologic model ; reaeration rates ; stream metabolism ; watershed ; physicochemistry ; land use practices ; experimental watershed ; suspended particulate matter ; stream water temperature ; watershed management ; bacteria ; land-use practices ; environmental persistence ; saturated hydraulic conductivity ; pedotransfer function ; model validation ; Chesapeake Bay Watershed ; experimental watershed study ; human dimensions of water ; watershed modeling ; hydrological modeling ; water pollutants ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: This Special Issue provides an insight, collated from 26 articles, focusing on various aspects of the Fit-For-Purpose Land Administration (FFPLA) concept and its application. It presents some influential and innovative trends and recommendations for designing, implementing, maintaining and further developing Fit-For-Purpose solutions for providing secure land rights at scale. The first group of 14 articles is published in Volume One and discusses various conceptual innovations related to spatial, legal and institutional aspects and its wider applications within land use management. The second group of 12 articles is published in Volume Two and focuses on case studies from various countries throughout the world, providing evidence and lessons learned from the FFPLA implementation process.
    Schlagwort(e): complete cadastre ; legal element ; fixing boundary ; eligible landowner ; agreement ; boundary marker ; fit-for-purpose land administration (FFP LA) ; violent conflict ; United Nations ; extra-legal ; transitional justice ; peace building ; land governance ; power relations ; securing land rights ; land registration ; development impacts ; fit-for-purpose land administration ; land administration ; decentralization ; India ; fit-for-purpose ; institutions ; governance ; politics ; Amazon ; deforestation ; Fit-For-Purpose land administration ; participatory mapping ; indigenous land conflict ; Cumaribo ; Colombia ; community-based land adjudication ; components of adjudication ; land tenure ; land rights ; good practices ; updating land records ; systematic land registration ; unconventional approach ; case study ; Benin ; cadaster ; land administration domain model ; LADM ; cadastre ; FFPLA ; customary tenure ; land inventory ; land management ; mobile-based applications ; pro-poor ; land surveying ; tenure security ; land rights and tenure ; fit-for-purpose approach ; human rights ; design science research ; design thinking ; fit for purpose ; spatial data quality ; spatial data quality assurance ; maintenance ; update ; upgrade ; upkeep ; renewal ; data quality ; spatial framework ; STDM ; technology ; UAV ; feature extraction ; rapid urbanization ; climate change ; pandemic ; urban resilience ; spatial ; legal ; and institutional frameworks ; land tenure security ; pro-poor land recordation ; land governance reform ; cost effectiveness ; innovative technology ; case studies ; Uganda ; customary land tenure ; land recordation tools ; semantic technologies ; land information system ; fit-for-purpose land management ; aerial and street level imagery ; machine learning ; integrated land programs ; land policy ; pilot study ; informal settlements ; urban development ; Brazil ; community-based crowdsourcing ; SiGIT ; Ecuador ; land and resources rights ; public-private partnerships ; corporate social responsibility ; poverty reduction ; business driven solutions ; social enterprises ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: During cell metabolism, oxygen is partially reduced to reactive oxygen species (ROS) that play a physiological role in cellular processes. However, an imbalance between the production of ROS and the ability of defenses to detoxify the organism provokes oxidative stress. Oxidative stress and its subsequent damages to vital cellular components have been associated with numerous severe chronic disorders. In addition, oxidation reactions are responsible for food deterioration during processing and storage. Peptides from animal and vegetal food sources have attracted attention due to the large evidence of their in vitro antioxidant properties. In addition to their potential as safer alternatives to synthetic antioxidants used to prevent oxidative reactions in foods, antioxidant peptides can also act by reducing the risk of numerous oxidative stress-associated diseases. Furthermore, peptides can act synergistically with nonpeptide antioxidants, enhancing their protective effect. This Special Issue of the Foods journal includes outstanding papers illustrating examples of the most recent advances on antioxidant peptides from both vegetal and animal sources. The existing data on their bioactivities demonstrated by in silico, in vitro, and animal models are included as well as the mechanisms of action of identified antioxidant peptides.
    Schlagwort(e): food peptides ; reactive oxygen species ; antioxidant enzymes ; whey protein hydrolysate ; hydrolysis condition ; food antioxidant ; ORAC ; cellular ROS ; HepG2 ; peptides ; egg white ; egg yolk ; antioxidant peptides ; sarcopenia ; whey protein ; muscle ; C2C12 ; aged animals ; older adult ; exercise ; bioactive peptides ; animal protein ; multifunctionality ; antioxidant activity ; in silico ; cell models ; fruit residues ; antioxidant ; extraction ; albumin ; albumin peptide ; antioxidant peptide ; bioactive peptide ; mung bean ; mung bean albumin ; peptide sequencing ; Vigna radiata ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: As an important tool of systems biology, proteomics has enabled a deep understanding of different plant processes and functions. Complemented with genomic data, computational tools, and improved sample preparation strategies, proteomics has an unprecedented opportunity to characterize plant proteoforms in high spatial and temporal resolution. This special issue of Plant Proteomic Research 4.0 captures the recent advancements in proteomics and addresses the current challenges of plant stress response and resilience in the ever-changing climate. It contains 12 articles, including three reviews and nine original research articles. The three reviews deal with pollen phosphoproteomics, starch biosynthesis-related proteins and posttranslational modifications (PTMs) in rice developing seeds, and PTMs of waxy proteins in rice grain. The nine research articles include three related to temperature, two on water stress, two on salt stress, one on fungal pathogen, and the last one on field-grown potato apoplast proteome. The articles reflect the current frontiers of plant proteomics, focusing on themes of environmental stresses, proteoforms/PTMs, crop species, and new development in data-independent acquisition mass spectrometry. They provide readers insights into current technologies, their utility in understanding plant growth and resilience, as well as directions of proteomics in the frontiers of systems biology and synthetic biology.
    Schlagwort(e): peptide markers ; Quercus ilex ; drought tolerance ; targeted post-acquisition proteomics ; plant pathogenesis responses ; quantitative proteomics ; data-independent acquisition ; Phytophthora infestans ; waxy ; amylose ; posttranslational modification ; GBSSI ; rice ; wheat ; salt stress ; physiological characteristics ; ER proteome ; label-free quantitation ; starch biosynthesis ; proteomics ; starch functionality ; cooking and eating quality ; Mesembryanthemum crystallinum ; McHB7 ; transcription factor ; late embryogenesis abundant ; Arabidopsis ; seed germination ; metabolomics ; heat-stable proteome ; dehydrins ; LEA transcripts ; intrinsically disordered proteins ; floral thermogenesis ; Nelumbo nucifera ; DIA-based quantitative proteomics ; time series analysis ; protein-protein interaction network ; WGCNA ; mutant soybean ; flooding ; glycoprotein folding ; fermentation ; cell death ; rice endosperm ; phosphorylation ; high temperature ; sucrose and starch metabolism ; ABPP ; apoplast ; serine hydrolases ; β-glycosidases ; potato ; field-omics ; phosphoproteomics ; pollen tube ; male gametophyte ; root hair ; signal transduction ; kinase motif ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Our world is facing many challenges, such as poverty, hunger, resource shortage, environmental degradation, climate change, and increased inequalities and conflicts. To address such challenges, the United Nations proposed the Sustainable Development Goals (SDG), consisting of 17 interlinked global goals, as the strategic blueprint of world sustainable development. Nevertheless, the implementation of the SDG framework has been very challenging and the COVID-19 pandemic has further impeded the SDG implementation progress. Accelerated efforts are needed to enable all stakeholders, ranging from national and local governments, civil society, private sector, academia and youth, to contribute to addressing this dilemma. This volume of the Climate Change and Environmental Sustainability book series aims to offer inspiration and creativity on approaches to sustainable development. Among other things, it covers topics of COVID-19 and sustainability, environmental pollution, food production, clean energy, low-carbon transport promotion, and strategic governance for sustainable initiatives. This book can reveal facts about the challenges we are facing on the one hand and provide a better understanding of drivers, barriers, and motivations to achieve a better and more sustainable future for all on the other. Research presented in this volume can provide different stakeholders, including planners and policy makers, with better solutions for the implementation of SDGs. Prof. Bao-Jie He acknowledges the Project NO. 2021CDJQY-004 supported by the Fundamental Research Funds for the Central Universities. We appreciate the assistance from Mr. Lifeng Xiong, Mr. Wei Wang, Ms. Xueke Chen and Ms. Anxian Chen at School of Architecture and Urban Planning, Chongqing University, China.
    Schlagwort(e): climate change ; sustainable development goals ; urban transformation ; decarbonization ; built environment ; governance ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-03-21
    Beschreibung: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Schlagwort(e): hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
    Sprache: Englisch
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: This Special Issue explored different topics concerning recent progress in the synthesis and characterization of suitable innovative macromolecular systems, proposed as carriers of specific antimicrobial molecules, to be employed in the biomedical and pharmaceutical fields. Many infectious diseases are induced by omnipresent micro-organisms, including bacteria, viruses, protozoa, fungi, and algae, and, consequently, are very common, accounting for a significant share of the global disease burden. Unfortunately, antimicrobial resistance, adverse effects, and the high cost of antimicrobials are crucial health challenges worldwide. One of the common efforts in addressing this issue lies in improving the existing antimicrobial delivery systems. In this regard, nanoparticles as well as three-dimensional hydrophilic systems represent valuable tools able to ensure excellent performances. Biocompatible polymeric particles, entrapping these bioactive molecules, are capable of releasing them over a desired period of time, thereby decreasing the frequency of their administration. At the same time, these systems are able to protect antimicrobial drugs from degradation, enhancing their bioavailability. This Special Issue serves to highlight and capture the contemporary progress recorded in this field.
    Schlagwort(e): film nanocomposite ; essential oil ; supercritical CO2 ; long-term package ; hybrid nanoparticles ; biocompatible polymer ; antimicrobial amphiphiles ; dynamic light scattering ; scanning electron microscopy ; cell viability from counting of colony-forming unities ; antimicrobial activity of nanoparticles ; Escherichia coli ; Staphylococcus aureus ; Candida albicans ; hydrogel ; polyvinyl alcohol ; aliphatic dicarboxylic acids ; sustained release ; linezolid ; equilibrium swelling ratio ; accumulative release ; thermogravimetric analysis ; gram-negative bacteria ; multidrug resistance ; polymer therapeutics ; colistin ; polymyxin B ; nanoliposomes ; MDR-Bacteria ; chitosan ; nanotechnologies ; plant extracts ; agro-food-wastes ; antimicrobial agents ; polymeric nanocarriers ; mixed polymeric micelles ; drug delivery ; antibiotics ; Pluronic F127 ; antimicrobial agent ; polymeric nanomaterial ; self-assembly ; antimicrobial peptide ; silver nanoparticle ; anti-biofilm ; wound healing ; bromelain ; nisin ; bioactivity ; biomedicine ; carrier ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-05-06
    Beschreibung: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Schlagwort(e): systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Sprache: Englisch
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-06-21
    Beschreibung: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Schlagwort(e): Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 12
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: In light of the considerable impact of global food supply chains on climate change, more sustainable ways of producing, distributing, and consuming food appear critical for sustainable development. With the aim of contributing to this topic, this Special Issue on sustainable food consumption and food marketing addresses various relevant issues related to food consumption, including innovative and sustainable forms of food production and consumption, animal welfare and meat consumption, price transmission, social media communication, alternative food production, and organic agriculture, among others. As such, this Special Issue sheds light on more sustainable and carbon-friendly food production and consumption systems from various angles. It delivers valuable scientific evidence for the transformation of current carbon-based food supply chains to more eco-friendly, fair, and future-oriented food supply chains.
    Schlagwort(e): aquaponics ; Structural Equation Modeling ; consumer behavior ; purchase intention ; willingness to pay ; sustainability ; food market ; veganic ; vegan-organic ; vegan ; stockless ; attitudes ; environmental marketing ; green product ; green consumer ; green purchase decision ; consumer behaviour ; theory of planned behaviour ; sustainable consumption ; Bangladesh ; out-of-home catering ; sustainable nutrition ; variety seeking ; spontaneous choice ; company canteens ; trust ; social media ; small and medium enterprises ; Bresse Gauloise ; choice experiment ; dual-purpose breeds ; faba beans ; Kollbecksmoor ; theory of planned behavior ; Vorwerkhuhn ; White Rock ; green products ; palm oil free ; structural equation modeling ; SEM ; sustainable food consumption ; food waste ; theoretical framework ; food tourism ; community-based tourism ; sustainable development ; community engagement ; rural development ; food heritage ; carbon-friendly food ; emotions ; animal welfare ; cured ham ; discrete choice experiment ; latent construct model ; market instability ; nonlinear empirical dynamics ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Cognitive building is a pioneering topic envisioning the future of our built environment. The concept of "cognitive" provides a paradigm shift that steps from the static concept of the building as a container of human activities towards the modernist vision of "machine à habiter" of Le Corbusier, where the technological content adds the capability of learning from users' behavior and environmental variables to adapt itself to achieve major goals such as user comfort, energy-saving, flexible functionality, high durability, and good maintainability. The concept is based on digital frameworks and IoT networks towards the concept of a smart city.
    Schlagwort(e): explainable post occupancy ; humanoid robot ; lighting simulation software ; BIM ; openBIM ; IFC ; IoT ; sensors ; cognitive buildings ; asset management ; digital twin ; BEM ; simulation modelling ; dynamic simulation ; Building Information Modelling (BIM) ; Internet of Things (IoT) ; facility management ; cyber-physical systems ; Building Management System ; Digital Twin ; Post-Occupancy Evaluations ; cognitive ; digital twins ; building lifecycle management ; artificial intelligence ; decision support ; self-learning ; optimization ; building performance simulation ; lighting simulation ; lighting quality ; visual comfort ; office field study ; evidence-based design ; building information modeling ; HVAC ; fan coil ; Internet of Things ; predictive maintenance ; fault detection ; smart building ; sustainable building ; construction projects ; BIM implementation ; stakeholders ; barriers ; construction product ; servitization ; level of evidence ; level curves ; ground slopes ; embankments ; road and rail design ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: In this book are reported nine works related to land subsidence monitoring using remote sensing techniques. Land subsidence is a common phenomenon in many regions of the world, where it causes degradation of local ecosystems and disruption of economic activities. Its effects are more evident in densely populated areas in particular in low-lying territories such as river deltas and coastal areas where the combination of land subsidence and sea level rise increases the flooding risk. For this reason, the monitoring of ground deformations is a crucial step to obtain important information for the development of risk mitigation strategies. In the presented papers, the characteristics of land subsidence occurring in different study areas are described, and recent developments in the used methodologies for the monitoring of the ground displacements are discussed and validated also by means of ground-based data. Moreover, advantages and disadvantages of the adopted techniques are highlighted. The outcomes of these research works can provide national and local authorities with useful information for the implementation of integrated monitoring systems in the areas most affected by land subsidence.
    Schlagwort(e): land subsidence ; IPTA ; land-use ; water resource utilization ; groundwater change ; deformation ; geology ; Gävle ; InSAR ; PSI ; precise levelling ; sentinel-1 ; subsidence ; Sweden ; ALOS/PALSAR ; time series analysis ; SBAS ; hot spring water ; hydrothermal fluids ; Hakone Volcano ; satellite geodesy ; radar interferometry ; persistent scatterers ; distributed scatterers ; orbit combination ; Sentinel-1 ; cavern field ; salt deposit ; geophysical modeling ; underground gas storage ; GNSS ; ground movement ; subsidence monitoring ; integrated numerical simulation ; Dubrovnik ; satellite altimetry ; tide gauges ; vertical land motion ; DInSAR ; mining-induced tremors ; land surface deformation ; Upper Silesian Coal Basin ; Interferometry ; SNAP-StaMPS ; Ground deformation ; Po River Delta ; integrated monitoring ; time-series analysis ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 15
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: Extracellular vesicles (EVs) are particles wrapped in a lipid bilayer membrane and are naturally released from cells. This kind of cargo vessel is a nanostructure that mainly transfers lipids, proteins, various nucleic acid fragments, and metabolic components to neighboring cells or distant parts of the body through the circulatory system. EVs are of great significance to the communication mechanism between cells. This book collects feature articles to enhance our understanding of the biological characteristics of EVs and their potential applications.
    Schlagwort(e): extracellular vesicle ; precision oncology ; cancer biomarker ; prostate cancer ; drug delivery ; extracellular vesicles ; lysosome ; nanocarriers ; ultrasound ; size exclusion chromatography ; differential ultracentrifugation ; head and neck squamous cell carcinoma (HNSCC) ; exosomes ; cancer ; biomarker ; diagnostic ; therapy ; liquid biopsy ; small extracellular vesicles (sEV) ; tumor-derived exosomes (TEX) ; melanoma cell-derived exosomes (MTEX) ; proteomics ; tumor microenvironment ; biomarkers ; ectosomes ; neoplasia ; microvesicles ; small extracellular vesicles ; isolation ; purification ; size-exclusion chromatography ; ultracentrifugation ; sucrose density cushion ; lymph node ; spleen ; solid tissue ; microvesicle ; exosome ; cancer therapeutic ; drug carrier ; flow cytometry ; immunophenotyping ; swarm detection ; tumor-associated macrophages ; macrophage polarization ; mannose receptor ; HIV-1 Nef ; glioblastoma ; microRNA ; immunoprecipitation ; CD44 ; human milk ; nutrient ; microbiota ; microRNAs ; nanocommunicator ; diagnostic biomarker ; drug delivery vehicle ; personalized cancer immunotherapy ; therapeutic agents ; cell-to-cell communication ; ionising radiation ; non-targeted effects ; signalling ; imaging flow cytometry ; biomarker reservoirs ; cancer diagnostics ; disease monitoring ; large EVs ; ovarian cancer cells ; ES-2 ; OAW-42 ; adipose tissue origin mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 16
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-10-25
    Beschreibung: This reprint is related to the latest research in the field of thyroid surgery, including molecular and imaging diagnosis, surgical treatment, and the treatment of recurrent disease and advanced thyroid carcinoma.
    Schlagwort(e): thyroid carcinoma ; prophylactic central lymph node dissection ; lymph node metastases ; RET ; medullary thyroid carcinoma ; clinical management ; variants of uncertain significance ; differentiated thyroid cancer ; papillary thyroid cancer ; minimal extrathyroidal extension ; radioactive iodine therapy ; prognosis ; TNM ; histology ; multifocality ; lymph node metastasis ; vascular invasion ; autoimmune thyroid diseases ; radioiodine refractory ; Lenvatinib ; 18F-FDG-PET/CT ; cost-benefit analysis ; economics ; medical ; thyroid neoplasms ; radiomics ; ultrasound ; magnetic resonance imaging ; computer tomography ; prediction ; classification ; angiogenic microenvironment ; prognostic factors ; antiangiogenic therapy ; therapeutic target ; tumor microenvironment ; tumor behavior ; proliferation pathways ; cell cycle control pathways ; angiogenesis process ; thyroid cancer ; Gal-3 expression ; NIFTP ; EFVPTC ; lymphocytic thyroiditis (LT) ; immunohistochemical (IHC) analysis ; molecular imaging ; theranostics ; companion diagnostics ; immunoPET ; anaplastic thyroid cancer ; poorly thyroid cancer ; genetic landscape ; genetically guided therapy ; fluorodeoxyglucose F18 (18F-FDG) ; positron emission tomography (PET) ; magnetic resonance imaging (MRI) ; recurrence ; neoplasm metastasis ; thyroid surgery ; hypoparathyroidism ; fluorescence-guided surgery ; near-infrared autofluorescence ; PRKAR1A ; PKA ; Carney complex ; cAMP ; bone metastasis ; metastasectomy ; stereotactic radiosurgery ; ultrasound imaging ; thyroid nodule ; fine-needle aspiration ; papillary thyroid carcinoma ; lobectomy ; operative extent ; CONUT score ; tyrosine kinase inhibitors ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Sprache: Englisch
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  • 17
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: This Urological Cancer 2020 collection contains a set of multidisciplinary contributions to the extraordinary heterogeneity of tumor mechanisms, diagnostic approaches, and therapies of the renal, urinary tract, and prostate cancers, with the intention of offering to interested readers a representative snapshot of the status of urological research.
    Schlagwort(e): renal cell carcinoma ; iron ; macrophages ; chelation therapy ; urothelial carcinoma ; transcriptome ; microtubule ; MAP1B ; prognosis ; KLF5 ; androgen receptor ; cell proliferation ; tumorigenesis ; prostate cancer ; precision medicine ; whole genome sequencing ; optical mapping ; therapy ; prostate carcinoma ; prostate mpMRI ; machine learning ; artificial intelligence ; deep learning ; neural network ; angiogenesis ; angiogenic growth factors ; antiangiogenic therapy ; renal tumors ; prevention ; α1-adrenoceptor antagonists ; anoikis ; vascularity ; research model ; oncogenes ; tumor suppressor genes ; MR-guided ; radiotherapy ; MRgRT ; stereotactic ablative radiotherapy ; stereotactic ablative radiation therapy (SABR) ; renal cell cancer ; RCC ; online adaptive ; [68Ga]Ga-PSMA PET/CT ; dual-time point imaging ; delayed imaging ; biphasic imaging ; lesion positivity rate ; CXCL9 ; PD1 ; PD-L1 ; stage T1 NMIBC ; prostatic neoplasms/mortality ; prostatic neoplasms/epidemiology ; SEER Program ; bladder cancer ; transurethral resection ; en-bloc resection ; CPT1A ; fatty acids ; serine ; androgen response ; ROS ; oxidative stress ; DONSON ; Downstream Neighbor of SON ; biomarker ; metastatic spread ; diagnosis ; differential diagnosis ; histopathology ; immunohistochemistry ; stroma signature ; patient-derived xenografts ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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  • 18
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: In this book, the performance of homogeneous and heterogeneous catalysts applied in biomass processing was assessed, paying special attention to the main advantages and challenges related to their use. Indeed, these challenges are opportunities to develop new research lines that could be fruitful in the near future. Thus, different studies are included, dealing with diverse subjects, with one main goal in common: the improvement of different aspects related to biomass processing through the use of catalysts.
    Schlagwort(e): nanospheroids ; zinc-doped CaO ; natural triglycerides ; aminolysis ; heterogeneous catalyst ; recyclability ; catalyst ; sodium hydroxide ; fatty acid methyl ester ; central composite rotatable design ; operational conditions ; aerated irrigation ; soil enzyme activity ; soil microbial biomass ; soil respiration ; bio-derived phenol ; Ni-Cu-Co/Al2O3 ; in-situ hydrodeoxygenation ; cyclohexane ; hydrogenolysis ; biomass ; 5-hydroxymethylfurfural ; 2,5-furandicrboxylic acid ; aerobic oxidation ; metal catalysts ; acid catalysis ; biodiesel ; biofuel ; esterification ; fatty acid ; methanolysis ; molybdenum oxide ; transesterification ; vegetable oil ; fatty acid methyl esters ; 2-ethyl-1-hexanol ; 1-heptanol ; 4-methyl-2-pentanol ; viscosity ; flash and combustion points ; methyl oleate ; methyl ricinoleate ; cellulase ; cellulose ; paper sludge ; Saccharomyces cerevisiae ; synergism ; furfural ; carbon-supported catalyst ; xylose conversion ; iron ; heterogeneous catalysts ; thermoset polymer ; epoxy ; cellulose nanofiber ; curing characteristics ; thermal properties ; mechanical properties ; RSM ; numerical optimization ; keratinase ; feather ; Bacillus sp. ; amino acids ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 19
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: Due to their lightweight and high specific strength, Mg-based alloys are considered as substitutes to their heavier counterparts in applications in which corrosion is non-relevant and weight saving is of importance. Furthermore, due to the biocompatibility of Mg, some alloys with controlled corrosion rates are used as degradable implant materials in the medical sector. The typical processing route of Mg parts incorporates a casting step and, subsequently, a thermo–mechanical treatment. In order to achieve the desired macroscopic properties and thus fulfill the service requirements, thorough knowledge of the relationship between the microstructure, the processing steps, and the resulting property profile is necessary. This Special Issue covers in situ and ex situ experimental and computational investigations of the behavior under thermo–mechanical load of Mg-based alloys utilizing modern characterization and simulation techniques. The papers cover investigations on the effect of rare earth additions on the mechanical properties of different Mg alloys, including the effect of long-period stacking-ordered (LPSO) structures, and the experimental and computational investigation of the effect of different processing routes
    Schlagwort(e): Arabidopsis ; abiotic stress response ; photosynthesis ; phosphoglycolate phosphatase ; photorespiration ; 2-phosphoglycolate ; Arabidopsis thaliana ; glycolate oxidase ; protein phosphorylation ; Zea mays ; Portulaca grandiflora ; C4 photosynthesis ; Crassulacean acid metabolism (CAM), evolution ; development ; PEP carboxylase ; Portulacaceae ; glycine decarboxylase ; metabolite signaling/acclimation ; TCA cycle ; Calvin–Benson cycle ; photoperiodic changes ; redox-regulation ; environmental adaptation ; Glycolate oxidase ; evolution ; Archaeplastida ; Cyanobacteria ; MCF ; oxidative phosphorylation ; mitochondrial carriers ; transporters ; energy balancing ; cyclic electron flux ; malate valve ; C3 cycle ; acclimation ; chlorophyll a fluorescence ; fluctuating light ; natural variation ; pyruvate kinase ; glycolysis ; respiratory metabolism ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 20
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    Cambridge University Press
    Publikationsdatum: 2022-02-11
    Beschreibung: law; medicine; medico legal; bioethics and health law; ethics; philosophy
    Schlagwort(e): law; medicine; medico legal; bioethics and health law; ethics; philosophy ; bic Book Industry Communication::L Law ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAD Bio-ethics ; bic Book Industry Communication::H Humanities::HP Philosophy
    Sprache: Englisch
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  • 21
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-05-06
    Beschreibung: Chronic intestinal diseases are increasing around the world. With poor quality of life and expensive healthcare costs, the patients demand novel approaches and treatments for better clinical outcomes. This book illustrates the state of the art and the envisaged near future in the management of these pathologies.
    Schlagwort(e): chronic intestinal pseudo-obstruction ; parenteral nutrition ; pediatrics ; myopathy ; neuropathy ; IBS ; microbiota ; visceral hypersensitivity ; colorectal motility ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; anti-TNF ; ustekinumab ; vedolizumab ; postoperative complications ; surgery ; preoperative therapy ; biologic therapy ; bio-naïve ; IBD ; pro-inflammatory cytokines ; lymphocyte migration ; treatment ; inflammatory bowel diseases ; biologic treatment ; combination ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 22
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: The use of renewable energy sources (RESs) is a need of global society. This editorial, and its associated Special Issue “Grid-Connected Renewable Energy Sources”, offers a compilation of some of the recent advances in the analysis of current power systems that are composed after the high penetration of distributed generation (DG) with different RESs. The focus is on both new control configurations and on novel methodologies for the optimal placement and sizing of DG. The eleven accepted papers certainly provide a good contribution to control deployments and methodologies for the allocation and sizing of DG.
    Schlagwort(e): solar energy ; wind energy ; energy storage ; renewable energy integration ; Europe ; advanced metering infrastructure ; data acquisition ; IEC standards ; low-cost ; open source ; power measurement ; smart meter ; uncertainty evaluation ; frequency stabilization ; coordinated control ; wind turbine generator ; high-fidelity battery model ; releasable and absorbable energy ; photovoltaic emulator ; photovoltaic panel ; single diode model ; MPPT ; FSWT-SCIG ; battery storage system ; power system stability ; synchronous generator ; hybrid system ; voltage source converter ; passivity-based control ; proportional-integral control ; voltage regulation ; bi-directional converter ; LC impedance source converter ; DC–DC power converter ; bi-directional power flow ; alternating current networks ; direct current networks ; optimal power flow ; non-linear optimization ; control of power electronic converters ; distributed generation ; mixed-integer nonlinear programming ; second-cone programming ; discrete-sine cosine algorithm ; metaheuristic optimization ; DG placement ; evolutionary algorithms ; energy management ; fuzzy controller ; power systems analysis ; interconnected power systems ; latencies ; time-delay effects ; wide area monitoring systems ; renewable energy conversion ; power conditioning devices ; renewable energy policies ; power quality ; computations methods ; control strategies ; electric vehicle charging ; energy management systems ; ancillary services ; monitoring ; prognostic and diagnostic ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 23
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-06-21
    Beschreibung: This Special Issue is aimed to offer an overview of studies presenting new rehabilitation approaches addressed to children with neurodevelopmental disorders, designed to enhance the effects of learning processes through the use of new technologies. The contributions of this Special Issue, authored by researchers and clinicians from some of the most valued Italian scientific institutions in the field of neurodevelopmental disorders, can offer some useful data and advice on the use of technology in rehabilitation and telerehabilitation to researchers, rehabilitators, clinicians and pratictioners (psychologists, neuropsychologists, speech therapists, etc.).
    Schlagwort(e): neurorehabilitation ; cognitive enhancement in children ; tech mediated rehabilitation ; developmental coordination disorders ; virtual reality ; telerehabilitation ; specific learning disorders ; cerebral palsy ; well-being ; dyslexia ; rhythm ; music therapy ; intervention ; developmental dyslexia ; new technologies ; augmented reality ; good practices ; Delphi method ; rehabilitation ; remote intervention ; children ; age ; severity ; improvement ; follow-up ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 24
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Coastal regions are susceptible to rapid changes, as they constitute the boundary between the land and the sea. The resilience of a particular segment of coast depends on many factors, including climate change, sea-level changes, natural and technological hazards, extraction of natural resources, population growth, and tourism. Recent research highlights the strong capabilities for remote sensing applications to monitor, inventory, and analyze the coastal environment. This book contains 12 high-quality and innovative scientific papers that explore, evaluate, and implement the use of remote sensing sensors within both natural and built coastal environments.
    Schlagwort(e): big data applications ; data processing ; data visualization ; neural networks ; reduction ; coastal waters ; urban expansion ; remote sensing and GIS ; expansion types and rates ; major explanatory factors ; Miami metropolitan area ; cliff coastlines ; cliff retreat ; time-series analysis ; airborne laser scanner ; warm upwelling ; sea surface temperature ; numerical modelling ; winter ; southern Baltic Sea ; beach monitoring ; mobile terrestrial LiDAR ; intensity calibration ; beach surface moisture ; Baltic coast ; Poland ; CORINE Land Cover ; land cover flow ; urbanisation ; afforestation ; deforestation ; spatial analysis ; SDGs ; coastal habitats ; ecosystem monitoring ; land cover mapping ; random forest algorithm ; Sentinel-2 ; modified soil-adjusted vegetation index 2–MSAVI2 ; normalized difference water index 2–NDWI2 ; brightness index 2–BI2 ; oil spill ; remote sensing ; review ; machine learning ; deep learning ; trajectory modeling ; vulnerability assessment ; coastal geomorphology ; shoreline change ; coastal process ; monitoring ; geomatic techniques ; Po River Delta ; archival multi-temporal data ; coastline changes ; emerged/submerged surfaces ; land subsidence ; relative sea level rise 2100 ; land cover ; dune coast ; air photograph ; South Baltic Sea ; coastal monitoring ; estuaries ; IoT ; lidar ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 25
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: There is a growing recognition that rapid action in response to climate change is urgently necessary, and that many of the responsibilities for this action (e.g., relating to transport, land-use planning and economic development) rest at the local level. This is attested to by the growing number of local authorities that have declared climate emergencies across the globe. Responding to this emergency will require significant changes in the assumptions, expectations, priorities and procedures of locally elected representatives and government officials. This Special Issue will explore the responses of local government, as a key locus of sustainability governance, to the need for rapid climate action, drawing on examples from diverse locations (UK, western Europe, Chile and South Africa) and at various scales (from the smallest local areas, to city regions, counties and provinces).
    Schlagwort(e): climate change ; local government ; climate governance ; urban transport ; politics ; local climate action ; climate emergency ; phronesis ; practical wisdom ; crisis ; UK ; Paris Agreement ; carbon budgets ; transport ; governance ; carbon accounting ; scalar ; top-down ; bottom-up ; local governments ; critical infrastructure investment ; capacities ; political leadership attributes ; municipal organizational robustness ; Chile ; pop-up consultancy centre ; local authorities ; home renovation ; decentralised approach ; home-owner renovation journey ; business models ; multi-level governance ; informal settlements ; sanitation services ; institutional remaking ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 26
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Salamanders are relevant components of many terrestrial and aquatic ecosystems. However, despite the importance of salamanders in many resource–consumer networks, their functional role remains remarkably understudied. Therefore, this volume, entitled The Ecological Role of Salamanders as Prey and Predators, provides an opportunity for researchers to highlight the new research on the ecological role of salamanders and newts in prey–predator systems, their trophic behavior, and the variability of their trophic niche in space and time. Various innovative methods, such as COI metabarcoding and network analysis, are applied in the present study to test both the classical and new hypotheses concerning the trophic ecology of salamanders and their interactions with their prey. The present volume is composed of one review and seven research papers, all of which are published after undergoing a complete and impartial peer-review process.
    Schlagwort(e): artificial cave ; ecotone ; prey-predator system ; salamanders ; Speleomantes ; subterranean habitat ; amphibia ; energy flow ; habitat coupling ; predator–prey interactions ; top–down control ; trophic cascades ; trophic ecology ; Urodela ; cave biology ; prey ; hypogean ; underground ; stygofauna ; Monolistra ; Sphaeromatidae ; Niphargus ; flatworm ; aqueduct ; seepage ; individual diet specialization ; ecological opportunity ; diet ; plethodontid ; community ecology ; Triturus ; Lissotriton ; coexisting species ; trophic niche ; niche width ; niche variation hypothesis ; amphibians ; feeding ecology ; individual specialization ; resource selection ; Hydromantes ; body condition ; biospeleology ; parental species ; size ; capture-mark-recapture ; COI ; DNA metabarcoding ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 27
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    Publikationsdatum: 2023-05-10
    Beschreibung: Recent research of epidural and transcutaneous electrical spinal cord stimulation has demonstrated unprecedented improvements in motor function thought to be irreversibly lost due to chronic, severe spinal cord injury. Studies in parallel assess these methods for spasticity management as an alternative to medications that are often accompanied by deleterious side effects. As a noninvasive intervention, transcutaneous spinal cord stimulation holds the great potential to find its way into wide clinical application. Its firm establishment and lasting acceptance as clinical practice in spinal cord injury will not only hinge on the demonstration of safety and efficacy, but also on the delineation of a conceptual framework of the underlying physiological mechanisms. This will also require advancing our understanding of immediate and temporary effects of transcutaneous spinal cord on neuronal circuits in the intact and injured spinal cord. The purpose of this collection of papers is to bring together peers in the field to share—and eventually fuse—their pertinent research into current neurorehabilitation practice by providing a clinical perspective and novel insights into the underlying mechanisms.
    Schlagwort(e): human ; neuromodulation ; neurorehabilitation ; non-invasive ; spinal cord injury ; transcutaneous spinal cord stimulation ; evoked potentials motor ; motor activity ; spinal cord stimulation ; spinal reflexes ; voluntary ankle control ; walking ; hand training ; combined intervention ; cervical spinal cord ; activity-based therapy ; gait ; locomotion ; paraplegia ; task-specific training ; tetraplegia ; use-dependent plasticity ; antispasmodic ; electrical stimulation ; pendulum test ; intensity effect ; muscle strength effect ; cervical ; corticospinal pathway ; spinal reflex ; electrically evoked spinal motor potentials ; cervical spinal cord injury ; motor evoked potentials ; automation ; electromyography ; noninvasive ; Parkinson’s disease ; posterior root-muscle reflexes ; spasticity ; transcutaneous ; biophysics ; H reflex ; M wave ; posterior root-muscle reflex ; posterior root stimulation ; spine alignment ; spinal cord ; spine ; spinal stimulation ; corticospinal tract ; functional connectivity ; movement ; sensorimotor networks ; task dependence ; interlimb coordination ; rehabilitation ; neurophysiology ; Hoffmann (H)-reflex ; motor-evoked potential ; electroencephalography ; event-related desynchronisation ; posterior root muscle reflex ; evoked potentials ; lumbar spinal cord ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
    Sprache: Englisch
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  • 28
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: The concept of advanced therapy medicinal products (ATMPs) encompasses novel kinds of medicines for human use that are based on genes, cells or tissues. These intend to offer not only regeneration, but complete functional recovery of diseased tissues and organs using different strategies. Gene therapy, cell therapy and tissue engineering are the main areas in which promising advanced therapies are emerging. The eye is a very complex organ whose main structures, the cornea and the retina, play a pivotal role in maintaining normal vision, as severe alterations in these tissues can lead to blindness. Ocular tissues are starting to benefit from ATMPs by fighting against the enormous complexity and devastating potential of many ocular diseases. However, developments arising from this field of work face important challenges related to vectors to deliver drugs and genetic material to target tissues, suitable biomaterials to prepare cell scaffolds and cell stemness, among others—not to mention the complicated legislation around ATMPs, the complexity in production and quality control and the absence of standardized protocols.The purpose of this Special Issue is to serve as an overview of the current progress in the application of cell and gene therapies, as well as tissue engineering to restore functionality in diseased ocular structures, and the challenges linked to reaching patients.
    Schlagwort(e): MPC polymer ; dry eye ; ocular surface ; lacrimal fluid ; mucin ; 3D bioprinting ; cornea ; retina ; ophthalmology ; tissue regeneration ; electrospinning ; conjunctiva ; decellularized tissue matrix ; small intestinal submucosa ; urinary bladder matrix ; polycaprolactone ; fiber ; tissue engineering ; stratification ; conjunctival epithelial cells ; hydrogel ; keratoplasty ; scaffold ; collagen ; advanced therapy medicinal product ; ATMP ; cell therapy ; gene therapy ; eye ; ocular ; regulatory ; marketing authorization ; double-crosslinking ; carbodiimide ; glutaraldehyde ; sodium metabisulfite ; sodium borohydride ; EDC/NHS ; stem cells ; retinal diseases ; optic nerve diseases ; cell replacement ; cell sources ; advanced therapies ; ocular mucosa ; blindness ; CLET ; limbal niche ; limbal stem cell ; LSCD ; mesenchymal stem cell transplantation ; MSCT ; corneal limbus ; decellularized xenograft ; recellularization ; mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 29
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: Dear Colleagues, When Hayflick and Moorhead coined the term “cellular senescence” (CS) almost 60 years ago, this phenomenon was understood as a mechanism, usually induced by activation of the DNA-repair machinery, to prevent uncontrolled proliferation. Meanwhile, additional beneficial roles for CS have been identified, such as embryonic development and wound healing. The senescence associated secretory phenotype (SASP) activated in most senescent cells (SC) signals to the immune system “come here and remove me”. In organisms with young and functional immune systems, occurring SC are usually detected and removed. If SC remain in the tissue expressing the SASP, this will cause not just a damaging local inflammation but can also induce remodeling and regeneration of the surrounding tissue as well as spreading of senescence. Old organisms show reduced regenerative potential and immune function which leads to accumulation of SC. Accordingly, accumulation of SC was observed in tissues of aged individuals, but importantly also in the context of age-related disorders, neurodegenerative, or cardiovascular diseases and others. Because of its detrimental effect of the surrounding tissue, accumulation of SC is not just a consequence, but can rather been understood as a major driver of aging. In line with this, recent studies described that removal of SC showed beneficial effects on healthspan and lifespan. This exciting research led to the discovery of “senolytics”, drugs which can kill SC. Given the heterogeneity of cell types that show senescence-like phenotypes, including heart muscle and post-mitotic neuronal cells, further research is required to unravel the molecular background that renders a cell type vulnerable to senesce. Additionally, it will be important to understand how senescence is cell type-specifically induced and which molecules serve as drug targets to prevent senescence and its spreading, or actively kill SC. This special issue will shed light on the molecular pathways of CS and inflammaging and on possible strategies to interfere with these processes. Dr. Markus Riessland Guest Editor
    Schlagwort(e): γH2AX ; Alzheimer’s disease ; DNA damage ; mild cognitive impairment ; senescence ; secreted protein acidic and rich in cysteine ; regeneration ; homeostasis ; cellular senescence ; biology of aging ; neurodegeneration ; brain ; geroscience ; senolytics ; tauopathy ; cancer ; stress response ; post-mitotic ; neuronal senescence ; amyotrophic lateral sclerosis ; senescence-associated secretory phenotype (SASP) ; cell-cycle ; melanoma ; pancreatic adenocarcinoma ; tumor infiltration ; chemotherapy resistance ; prostate ; inflammation ; AIM2 inflammasome ; POP3 ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Sprache: Englisch
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  • 30
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: This book examines the state of the art of biosorption as an economical and environmentally friendly technique for pollutant removal in wastewater. Several articles are included that develop the applications of biosorption showing the high efficiency and versatility of this process, as well as showing recent advances in this field. Different modalities of biosorption are demonstrated from free biomass to immobilized biomass, as well as the combination of biomass with modern materials to form composites, emphasizing the significant versatility of this technique. In addition, different examples with biomasses of very different natures are also included and discussed, as are the factors that influence biosorption processes. Other contributions offer some examples of apparently useless materials that are reused and applied in the elimination of pollutants. Therefore, this book is an excellent complement for those researchers who work on biosorption as well as a starting point for those who want to begin research on this topic.
    Schlagwort(e): landfill ; leachate treatment ; POME ; removal efficiency ; mixing ratio ; biosorbent ; Ni2+ ; background electrolytes ; kinetic modeling ; biosorption ; biomass ; bioaccumulation ; biocomposite ; pollutants ; metals ; emerging organic contaminants ; dyes ; Spirulina ; alginate ; immobilization ; fixed-bed column ; Mxene–CS composite ; Cr(VI) contaminated aqueous solution ; Green Synthesis ; treatment of wastewater ; heavy metals ; citrus waste biomass ; bio-sorbent ; pre-treatment ; activated carbon ; batch adsorption ; fixed-bed adsorption column ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 31
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-08-12
    Beschreibung: The scope of the Special Issue is research and reviews on evaluations of current practice, innovations in medication management, developments in therapeutics, and pharmaceutical science research that informs and improves practice and administration, as well as the social and administrative pharmacy. We will mainly feature original research, reviews, short reports, and clinical studies, but also case reports, descriptive/how-to, and commentary submissions for consideration.
    Schlagwort(e): older adults ; polypharmacy ; internal medicine ward ; community pharmacy ; drug disposal ; unused medication ; environment ; awareness ; practice ; ambulatory care facilities ; health workforce ; pharmacists ; Taiwan ; Commonwealth Partnerships for Antimicrobial Stewardship (CwPAMS) ; National Health Service (NHS) ; Chief Pharmaceutical Officer’s Global Health Fellowship ; CPhOGH Fellows ; CwPAMS ; pharmacy ; fellowship ; health partnerships ; antimicrobial resistance (AMR) ; global health ; leadership ; non-prescription medicines ; emergency contraception ; community pharmacies ; information gathering ; availability ; pricing ; mystery calls ; ulipristal acetate ; levonorgestrel ; Germany ; e-prescription ; prescription writing ; Jazan ; Saudi Arabia ; prescription errors ; medicine consumption ; defined daily dose ; adolescents and young adults ; cancer patients ; fragility ; pain ; MUR ; medication review ; barriers ; pharmacist ; pregabalin ; abuse ; community pharmacists ; reproductive health ; contraception ; emergency contraceptives ; patient education ; biosensing technology ; digital medicine system ; medication adherence ; medication event monitoring system ; nonadherence ; prescription opioids ; mortality ; standardized mortality ratio ; underlying cause of death ; prescriptions ; community pharmacy services ; emergency prescribing ; pharmacy practice ; pharmacy law and regulation ; COVID-19 ; additional monitoring ; black triangle ; adverse event reporting ; pharmacovigilance ; intervention ; outcomes ; systematic review ; pharmacy education ; decision to study in pharmacy ; selecting pharmacy as a first choice ; pharmacogenomics ; learning activity ; asynchronous learning ; virtual learning ; student survey ; Program of All-Inclusive Care for the Elderly ; adverse drug events ; medication-related problems ; drug-related problems ; medication safety ; Medicare ; Medicaid ; financial management ; pharmacy management ; business ; entrepreneurship ; pharmacy students ; perception ; attitudes ; ability ; interprofessional ; simulation ; acute care ; nursing ; students ; standardized patients ; high fidelity ; SPICE-R2 ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
    Sprache: Englisch
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  • 32
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: A growing interest has been devoted to the development of host systems for ionic and neutral species based on calixarenes. These cyclic oligomers show important host–guest properties, which has led to numerous applications in a broad range of fields, including organocatalysis, sensing, extraction and separation, and, more recently, biomedical applications. The relative ease of the functionalization of their upper and lower rims and the presence of a pre-organized cavity that is available in different sizes and conformations make calixarenes attractive building blocks for the construction of supramolecular assemblies. This book presents the most recent developments on the host–guest properties of calixarenes, as well as the new synthetic methods and applications.
    Schlagwort(e): thiosemicarbazone ; calix[4]arene ; metal complex ; X-ray structure ; antimicrobial ; anticancer ; copper ; supramolecular ; inclusion complex ; fluorescence ; sensor ; density functional theory ; calix[3]arenes ; metacyclophanes ; calixarene-analogous metacyclophanes ; inherent chirality ; host-guest chemistry ; dihomooxacalix[4]arenes ; naphthyl(thio)urea anion receptors ; alkylammonium hydrochlorides ; ditopic receptors ; chiral recognition ; NMR studies ; UV-Vis absorption studies ; fluorescence studies ; X-ray diffraction ; DFT calculations ; calixarene ; resorcinarene ; pillararene ; antibiotic ; fungicide ; biofilm inhibition ; calixarenes ; threading ; chirality ; barfate salts ; pseudorotaxane ; chiral axles ; chiral wheels. ; calixarene-like structure ; polyoxometalates ; nitronate ; crystal structure ; host–guest chemistry ; anion receptor ; anion ; sensors ; lanthanides ; UV–vis studies ; quantum yields ; lifetime measurements ; noncovalent synthesis ; hierarchical control ; calix[4]tubes ; metallo-porphyrins ; phthalimide derivatives ; conventional synthesis ; microwave irradiation ; ball milling ; NMR spectroscopy ; electronic absorption and fluorescence studies ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 33
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: It is widely believed that a large proportion of greenhouse gas emissions originated anthropogenically from the use of fossil fuels with additional contributions coming from manufactured materials, deforestation, soil erosion, and agriculture (including livestock). The global society actively supports measures to create a flexible and low-carbon energy economy to attenuate climate change and its devastating environmental consequences. In this Special Issue, the recent advancements in the next-generation thermochemical conversion processes for solid fuels and renewable energies (e.g., the operational flexibility of co-combustion of biomass and lignite, integrated solar combined cycle power plants, and advanced gasification systems such as the sorption-enhanced gasification and the chemical looping gasification) were shown.
    Schlagwort(e): hydrochar ; hydrothermal carbonization ; biogas upgrading ; CO2 capture ; pressure swing adsorption ; gasification ; kinetic model ; conversion model ; reaction model ; low-rank coal ; tar absorption ; process simulation ; validation study ; sensitivity analyses ; lignite ; lignite gasification ; fluidized-bed gasifier ; olivine ; solar cooling ; solar cooling system ; TRNSYS ; absorption chiller ; performance and analysis ; solar energy ; chemical looping ; biomass gasification ; process control ; CO2 absorption ; experimental study ; energy analysis ; exergy analysis ; CSP ; PTC ; ISCC ; power plant ; CFB combustion ; operational flexibility ; load transients ; fluctuating electricity generation ; renewables ; one-dimensional SEG model ; dual fluidized bed ; sorbent deactivation ; hydrodynamics ; kinetics ; fuel feeding rate ; biomass ; thermochemical conversion technologies ; combustion ; carbon capture and storage/utilization ; solar-driven air-conditioning ; integrated solar combined cycle ; energy and exergy analyses ; thermodynamic modeling ; dynamic process simulation ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 34
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Conflicts in forest management are unavoidable because of the large temporal and spatial scales characteristic of forests ecosystems and the large number of actors involved. Forests are multifunctional ecosystems par excellence, and it can be hypothesized that current public policies, and especially those labeled as societal transitions, can affect this widespread holistic management goal. In this Special Issue, the different contributions by the authors raise the questions of how different types of conflicts arise and what alternatives exist to solve those conflicts. The Issue contains examples from both temperate and tropical forests and addresses, for instance, conflicts arising from REDD+ programs, the declaration of new protected areas, the complexity of negotiating carbon offset targets, the loss of local knowledge because of demographic trends, and meeting biodiversity and biomass targets simultaneously, among others. We present a general typology of sources of conflicts because of two dimensions: a vertical dimension represented by bottom-up versus top-down approaches and a horizontal dimension arising by ecosystem extent and ownership boundaries. Awareness that new policies can be a source of unexpected conflicts calls for precaution while testing new ‘transition’ approaches.
    Schlagwort(e): forest planning and management ; rural community sustainability ; ecosystem services ; forest sociology ; forestry in the media ; forest vulnerability ; adaptive capacity ; multiple-use land management ; conflicting perspectives ; natural processes ; high-yield silviculture ; forest management ; multifunctionality ; carbon offset ; collective action ; conflict avoidance ; mitigation ; payment for ecosystem services ; social-ecological ; France ; protected areas establishment ; stakeholder participation ; landscape protection ; qualitative research ; Soutok Protected Landscape Area (Czech Republic) ; REDD+ ; conflict ; forests ; land tenure ; political ecology ; ecological unit ; synergy/trade-off ; spatial structure ; attribute characteristics ; forest sustainability ; production forests ; environment forests ; carbon credit ; retention approach ; common-pool resource management ; local vs. global ; economic oligopoly ; panacea paradigm ; renewable energy ; sectoral organization ; CHANS ; globalization ; historical data ; socio-ecological frameworks ; dry-edge ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 35
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: The trend of digitalization is an omnipresent phenomenon nowadays – in social life and in the dental community. Advancement in digital technology has fostered research into new dental materials for the use of these workflows, particularly in the field of prosthodontics and oral implantology.CAD/CAM-technology has been the game changer for the production of tooth-borne and implant-supported (monolithic) reconstructions: from optical scanning, to on-screen designing, and rapid prototyping using milling or 3D-printing. In this context, the continuous development and speedy progress in digital workflows and dental materials ensure new opportunities in dentistry.The objective of this Special Issue is to provide an update on the current knowledge with state-of-the-art theory and practical information on digital workflows to determine the uptake of technological innovations in dental materials science. In addition, emphasis is placed on identifying future research needs to manage the continuous increase in digitalization in combination with dental materials and to accomplish their clinical translation.This Special Issue welcomes all types of studies and reviews considering the perspectives of the various stakeholders with regard to digital dentistry and dental materials.
    Schlagwort(e): Dentistry ; Prosthodontics ; Implant ; dentistry ; Digital ; technology ; Dental ; materials ; Rapid ; prototyping ; CAD/CAM ; Optical ; scanning ; 3D ; printing ; Translational ; research ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 36
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-05-06
    Beschreibung: Rare diseases, or orphan diseases, are those that individually affect a small number of patients, but taken together affect over 300 million people worldwide. They are characterized by their etiological, diagnostic and evolutionary complexity, important morbi-mortality, with high levels of disability that entail and hinder the development of a normal vital subject, not only in those who suffer from them, but also their families; therefore, a comprehensive social health approach is necessary to address this problem.About 80% of rare diseases have a genetic origin, mainly monogenic; thus, genetic testing is mandatory for the confirmation of clinical diagnostics and to ensure correct genetic counseling. Next-generation sequencing (NGS) has enabled a revolution in genetic diseases, specially in rare diseases. However, their complexity makes diagnoses difficult even with the advent of NGS.In this Special Issue, we present several examples of the complexity of genetic diagnosis for most of these diseases and the consequences that genetic testing implies for genetic counseling. There are examples of the genetic heterogeneity of hearing loss, some metabolic and lisosomal disorders, ataxia, Prader–Willi syndrome, and three comprehensive reviews on syndromic retinal dystrophies, the complexity of the molecular diagnosis of neuromuscular disorders, and the value of genetic counseling before and after a genetic test.
    Schlagwort(e): retina ; inherited retinal diseases ; syndrome ; Turner syndrome ; mosaicism ; ring chromosomes ; growth hormone deficiency ; pituitary microadenoma ; clinical genetics ; early onset ataxia ; dystonia ; neurodevelopment ; network analysis ; bioinformatics ; ataxia ; phenotype ; child ; NGS ; next generation sequencing ; inborn errors of metabolism ; lysosomal disorders ; neuromuscular disease ; genetic testing ; whole exome sequencing ; Prader–Willi syndrome ; imprinting disorder ; recombinant human growth hormone ; insulin-like growth factor 1 ; HMGLD ; HMGCL ; HMG-CoA lyase deficiency ; inherited metabolic diseases ; familial hearing loss ; multiple diagnoses ; non-syndromic hearing loss ; ACTG1 ; MYH9 ; genetic counselling ; rare diseases ; professional recognition ; hearing loss ; genetic diagnosis ; SLC26A4 ; DFNB4 ; Tuvinians ; Altaians ; Southern Siberia ; Russia ; GSDME ; DFNA5 ; single-exon CNV ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 37
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: The need for energy is increasing and at the same time production from the conventional reservoirs is declining quickly. This requires an economically and technically feasible source of energy for the coming years. Among some alternative future energy solutions the most approachable source is from unconventional reservoirs. As the name “unconventional” implies it requires different and challenging approach to characterize and to develop such a resource. This special issue covers some of the technical challenges for developing unconventional energy sources from shale gas/oil, tight gas sand, and coalbed methane.
    Schlagwort(e): bedding fractures ; failure criterion ; lamina ; tight oil ; tight sandstone ; finite element simulation ; numerical simulation ; unconventional reservoir ; permeability ; group method of data handling ; artificial neural network ; well logs ; sensitivity analysis ; tight gas reservoir ; multi-fractured horizontal well (MFHW) ; unstable productivity model ; productivity forecast ; influencing factor analysis ; horizontal well with multiple finite-conductivity fractures ; elliptical-shaped drainage ; productivity index ; non-Darcy flow ; pressure-dependent conductivity ; reservoir properties ; void space structure ; porosity ; complex rocks ; NMR ; MICP ; CT ; SEM ; coal-bearing tight sandstone ; organic-rich clasts ; occurrence ; classifications ; formation mechanisms ; Ordos Basin ; hydraulic fracturing ; fracturing fluids ; fluids-rock interaction ; environmental implication ; history matching ; semianalytic model ; unconventional gas reservoirs ; multistage fractured horizontal wells ; fractal theory ; pore structure ; heterogeneity ; NMR measurements ; multifractal analysis ; shale reservoir ; elastic properties ; brittleness ; rock physics ; brittle spot identification ; shale gas ; reservoir characteristics ; gas content ; eastern Sichuan Basin ; the Da’anzhai member ; pulse decay method ; gas adsorption ; dual media ; unconventional core ; natural fracture ; influencing factor ; oil production ; carbonate rock ; basement reservoir ; Jizhong Sub-basin ; dynamic pore network modeling ; shale reservoirs ; water imbibition ; discrete element method ; modified fluid-mechanical coupling algorithm ; injection sequence ; well spacing ; stress shadow effect ; seismic location ; microseismic events ; waveform stacking ; induced seismicity ; CBM ; surfactant ; solid-free drilling fluid ; CBM reservoir wettability ; machine learning ; lithofacies ; umiat ; Alaska ; proppant transportation ; cross fractures ; CFD simulation ; dimensional analysis ; equilibrium proppant height ; coalbed methane ; Lattice Boltzmann method ; gas diffusion ; adsorption–desorption ; pore-scale ; clay minerals ; pore structures ; tight gas reservoirs ; Xujiaweizi Rift ; Northern Songliao Basin ; methane adsorption isotherm ; coal properties ; gradient boosting decision tree ; estimation model ; shale gas reservoir ; geology ; Gibbs excess adsorption ; supercritical adsorption ; gas viscosity ; high voltage spark discharge ; electrohydraulic effect ; electrical conductivity ; drilling ; rock damage ; pressure waves ; water fracturing ; turbulence effect ; Eulerian multiphase modeling ; proppant transport mechanism ; equilibrium height prediction model ; adaptive filtering ; complex noise canceling ; electromagnetic telemetry ; multifractured horizontal wells ; production analysis ; irregular stimulated region ; natural gas hydrate ; seismic modeling ; fractional derivatives ; gas geochemical characteristics ; noble gas ; shale gas evolution ; Large Igneous Province (LIP) ; gas loss ; geological structure ; gas controlling pattern ; neutral surface ; tectonic movement ; Bumu region ; seismic interpretation ; depositional environments characteristics ; Wheeler diagram ; seismic attributes ; heterogeneous sequence ; sample size ; neutron scattering ; mercury injection capillary pressure ; adsorption ; shale ; junggar basin ; hong-che fault zone ; carboniferous ; volcanic reservoir ; main controlling factors of hydrocarbon accumulation ; fracture ; vug ; micro CT ; carbonate ; wave velocity ; amorphous SiO2 ; X-ray diffraction ; X-ray fluorescence spectrometry ; scanning electron microscope ; quantitative analysis ; void ratio ; FEM ; ABAQUS ; matrix porosity ; kerogen porosity ; water saturation ; gas hydrate ; saturation ; deep learning ; recurrent neural network ; molecular simulation ; enhanced oil recovery ; methane ; shale petroleum ; technological development ; patent ; network analysis ; imbibition ; osmosis ; unconventional formations ; EOR ; water flooding ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 38
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: This Special Issue (SI) on “Land Degradation Assessment with Earth Observation” comprises 17 original research papers with a focus on land degradation in arid, semiarid and dry-subhumid areas (i.e., desertification) in addition to temperate rangelands, grasslands, woodlands and the humid tropics. The studies cover different spatial, spectral and temporal scales and employ a wealth of different optical and radar sensors. Some studies incorporate time-series analysis techniques that assess the general trend of vegetation or the timing and duration of the reduction in biological productivity caused by land degradation. As anticipated from the latest trend in Earth Observation (EO) literature, some studies utilize the cloud-computing infrastructure of Google Earth Engine to cope with the unprecedented volume of data involved in current methodological approaches. This SI clearly demonstrates the ever-increasing relevance of EO technologies when it comes to assessing and monitoring land degradation. With the recently published IPCC Reports informing us of the severe impacts and risks to terrestrial and freshwater ecosystems and the ecosystem services they provide, the EO scientific community has a clear obligation to increase its efforts to address any remaining gaps—some of which have been identified in this SI—and produce highly accurate and relevant land-degradation assessment and monitoring tools.
    Schlagwort(e): bfast ; Mann–Kendall ; Sen’s slope ; East Africa ; NDVI ; breakpoint analysis ; vegetation trends ; greening ; browning ; Kenya ; Uganda ; trend analysis ; land use ; land cover ; spatial heterogeneity ; mining development ; geographically weighted regression (GWR) ; Mann-Kendall ; arid and semi-arid areas ; salinization ; irrigated systems ; Niger River basin ; salinity index ; vegetation index ; TI-NDVI ; Sentinel-2 images ; high temporal resolution ; wind erosion modeling ; RWEQ ; GEE ; central Asia ; spatial-temporal variation ; land degradation ; archetypes ; self-organizing maps ; drivers ; savannah ; Nigeria ; reference levels ; REDD+ ; greenhouse gas emissions ; Xishuangbanna ; monitoring and reporting ; Normalised Difference Vegetation Index (NDVI) ; Vegetation Condition Index (VCI) ; drought ; land use-land cover ; remote sensing ; Botswana ; developing countries ; Google Earth Engine ; Landsat time series analysis ; semi-arid areas ; sustainable land management programmes ; precipitation ; breakpoints and timeseries analysis ; ecosystem structural change ; BFAST ; land degradation neutrality ; SDG ; land productivity ; Landsat ; vegetation-precipitation relationship ; soil organic carbon ; Kobresia pygmaea community ; unmanned aerial vehicle ; Gaofen satellite ; spatial distribution ; aridity index ; satellite-based aridity index ; remote sensing index ; salinized land degradation index (SDI) ; Amu Darya delta (ADD) ; satellite imagery ; gully mapping ; machine learning ; random forest ; support vector machines ; South Africa ; semi-arid environment ; shrub encroachment ; slangbos ; Earth observation ; time series ; Sentinel-1 ; Sentinel-2 ; Synthetic Aperture Radar (SAR) ; Soil Adjusted Vegetation Index (SAVI) ; Kyrgyzstan ; pastures ; MODIS ; land surface phenology ; drought impacts ; drought adaptation ; drought index ; vegetation resilience ; drought vulnerability ; standardized precipitation evapotranspiration index ; AVHRR ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 39
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Nowadays, forecast applications are receiving unprecedent attention thanks to their capability to improve the decision-making processes by providing useful indications. A large number of forecast approaches related to different forecast horizons and to the specific problem that have to be predicted have been proposed in recent scientific literature, from physical models to data-driven statistic and machine learning approaches. In this Special Issue, the most recent and high-quality researches about forecast are collected. A total of nine papers have been selected to represent a wide range of applications, from weather and environmental predictions to economic and management forecasts. Finally, some applications related to the forecasting of the different phases of COVID in Spain and the photovoltaic power production have been presented.
    Schlagwort(e): Direct Normal Irradiance (DNI) ; IFS/ECMWF ; forecast ; evaluation ; DNI attenuation Index (DAI) ; bias correction ; nowcast ; meteorological radar data ; optical flow ; deep learning ; Bates–Granger weights ; uniform weights ; (REG) ARIMA ; ETS ; Hodrick–Prescott trend ; Google Trends indices ; Himalayan region ; streamflow forecast verification ; persistence ; snow-fed rivers ; intermittent rivers ; costumer relation management ; business to business sales prediction ; machine learning ; predictive modeling ; microsoft azure machine-learning service ; travel time forecasting ; time series ; bus service ; transit systems ; sustainable urban mobility plan ; bus travel time ; learning curve ; forecasting ; production cost ; cost estimating ; semi-empirical model ; logistic map ; COVID-19 ; SARS-CoV-2 ; PV output power estimation ; PV-load decoupling ; behind-the-meter PV ; baseline prediction ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 40
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: Climate change is becoming visible today, and so this book—through including innovative solutions and experimental research as well as state-of-the-art studies in challenging areas related to sustainable energy development based on hybrid energy systems that combine renewable energy systems with fuel cells—represents a useful resource for researchers in these fields. In this context, hydrogen fuel cell technology is one of the alternative solutions for the development of future clean energy systems. As this book presents the latest solutions, readers working in research areas related to the above are invited to read it.
    Schlagwort(e): fuel cell powered vehicle ; medium- and heavy-duty trucks ; component sizing ; ownership cost ; optimization ; hybrid power systems ; renewable energy sources ; fuel cell systems ; required-power-following control ; fuel economy ; permanent magnet synchronous generator ; fault ride-through ; interval type-2 fuzzy logic system ; wind energy conversion ; proton exchange membrane fuel cell ; hydrogen economy ; fueling flows control ; global extremum seeking ; load following ; matlab ; simulink ; real-time capability ; dynamic fuel cell model ; electricity distribution networks ; optimal capacitor allocation ; Genetic Algorithm ; Particle Swarm Optimization ; Bat Algorithm ; Whale Algorithm ; Sperm-Whale Algorithm ; alternative energy ; energy efficiency ; fuel cell ; hydrogen energy ; stationary application ; electrical vehicle ; AC charging station in mode 3 ; PLC ; steam methane reforming ; steam methanol reforming ; electrical efficiency ; exergy efficiency ; LNG ; Stirling engine ; solar concentrator ; automation system ; human–machine interface ; sensors ; direct methanol fuel cell ; multi stacks ; portable power ; energy management system ; Internet of Things ; long-term ; in-field test ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 41
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: This book gathers reviews and articles on the role of O-GlcNAcylation in cancer underlying the pharmacological targeting of the O-GlcNAcylation enzymes OGT and OGA as a promising anticancer strategy. Particular attention is paid to the involvement of O-GlcNAcylation in the regulation of transcription and as a link between nutrition and epigenetic dynamics or cellular energy metabolism. The role of O-GlcNAcylation in metastasis, immune responses, and resistance to chemotherapeutic agents is also discussed.
    Schlagwort(e): UNC5A ; O-GlcNAcylation ; OGT ; EZH2 ; nutrition ; epigenetics ; colon cancer ; transcription ; O-GlcNAc ; O-GlcNAc transferase ; O-GlcNAcase ; mOGT ; mitochondria ; glucose ; energy metabolism ; breast cancer ; cellular stress ; cancer ; immune surveillance ; invasiveness ; lung adenocarcinoma ; SAM68 ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 42
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-11-17
    Beschreibung: The year 2021 saw the publication of the Special Issue “"Diseases of the Salivary Glands" (https://www.mdpi.com/journal/jcm/special_issues/Salivary_Glands), Part I, covering recent and novel advancements as well as future trends in the field of research evaluating diagnostic and therapeutic treatment of salivary gland (SGs) diseases. Given the enormous success of Part I, the Special Issue “Diseases of the Salivary Glands” Part II has been launched, with the firm belief that it will enrich the panorama of world research in this field. Topics include: 1) Clinical features and presentation of potentially malignant SG disorders; 2) Risk factors and etiopathogenesis of SGs tumors; 3) Etiopathogenesis and molecular mechanisms involved in the chronic inflammatory condition characterizing Sjӧgren’s syndrome; 4) New discoveries in the field of micro RNAs associated with Sjӧgren’s syndrome; 5) Molecular markers linked to development and progression of SG diseases: current knowledge and future implications; 6) More innovative techniques for the study of the SG diseases: current limitations and future directions.
    Schlagwort(e): xerostomia ; dry mouth ; protein–protein interaction ; drug target ; head and neck cancer ; Sjögren’s Syndrome ; major histocompatibility complex (MHC) ; human leukocyte antigen (HLA) ; autoantigens ; T cells ; E-cadherins ; salivary glands ; morphogenesis ; EMT ; Sjögren’s syndrome ; autoimmunity ; hydrogen peroxide ; adrenaline ; blood loss ; tonsillectomy ; fibrosis ; pleomorphic adenoma ; epithelial–mesenchymal transition ; carcinoma ex-pleomorphic adenoma ; 99mTc-interleukin-2 ; activated lymphocytes ; inflammation imaging ; Sjögren syndrome ; nuclear medicine ; radiopharmaceuticals ; PET ; SPECT ; Follistatin-like 1 protein ; TGF-β1 ; SMAD2/3 ; fluoride ; sodium fluoride ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 43
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: The present volume “New Trends in Lithium Niobate: From Bulk to Nanocrystals” contains the materials of a Special Issue of the MDPI journal Crystals dedicated to the memory of Prof. Dr. Ortwin F. Schirmer and provides a new synopsis of his research focusing on LiNbO3. It also includes recent developments, exemplifying the continued interest in this outstanding ferroelectric, non-linear optical and holographic crystal as a workhorse for testing and realizing new ideas and applications.This book starts with reviews on intrinsic and extrinsic crystal defects in LiNbO3 of single-crystal, thin-film or nano-powder forms, studied by various optical, magnetic resonance and nuclear methods, clarifying in particular the reasons for the suppression of anion vacancy formation upon thermal reduction, mechano-chemical processing or irradiations of various types. The reviews are followed by research papers on the experimental and theoretical investigation of small polarons, together with recent results on the properties of Li(Nb,Ta)O3 mixed crystals. Among the various contributions dealing with nonlinear optical applications, papers on device development, entangled photon pair generation and thin films on the Lithium Niobate On Insulator (LNOI) platform can also be found.
    Schlagwort(e): lithium niobate ; small polaron hopping ; transient absorption ; mode-locked laser ; nonlinear mirror mode locking ; lithium tantalate ; crystal structure ; chemical composition ; ferroelectrics ; second harmonic generation ; lead-free piezoelectrics ; intrinsic defects ; extrinsic defects ; elemental doping ; ferromagnetism ; diluted-magnetic oxides ; LiNbO3 ; LiTaO3 ; oxide crystals ; lanthanides ; luminescence ; LNOI ; ferroelectric domains ; domain-wall conduction ; AFM ; thin film lithium niobate ; TFLN ; x-cut LN ; domain walls ; piezoresponse force microscopy ; second-harmonic generation ; Raman scattering ; electro-optics ; whispering gallery resonators ; polarons ; photorefractivity ; Marcus-Holstein’s theory ; Monte Carlo simulations ; strontium titanate ; self-trapped electrons ; oxygen vacancies ; defects ; impurity ; intrinsic defect ; paramagnetic ion ; electron paramagnetic resonance ; electron nuclear double resonance ; lithium vacancy ; lithium ; niobate ; epitaxy ; thin film ; liquid phase epitaxy ; molecular beam epitaxy ; sputtering ; pulsed laser deposition ; chemical vapor deposition ; lithium niobate-tantalate ; piezoelectric ; acoustic ; high-temperature ; sensor ; Q-factor ; BAW resonator ; parametric down-conversion ; photon-pair generation ; extended phase matching ; microring resonator ; varFDTD ; lithium tantalate thin film ; electro-optical devices ; lattice location ; radiation damage ; ion beam analysis ; hyperfine interactions ; charge localization ; lattice deformation ; optical response ; density-functional theory ; Bethe-Salpeter equation ; nanoparticles ; nanopowders ; X-ray diffraction ; Raman spectroscopy ; temperature dependence of electroconductivity ; bipolarons ; defect structure and generation ; Li diffusion ; bulk crystals ; thin films ; nanocrystals ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 44
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: The Mediterranean Sea is a semi-enclosed basin which experienced different natural and anthropogenic phenomena causes of community or intra-species changes over time. The Mediterranean Sea went through dramatic changes in its biota through the last 6 million years and more quickly in the recent century. All the events left a footprint on the gene pool of marine species, on their morpho-anatomical features, and on the loss or expansion of the geographical range extent. Nowadays the Mediterranean basin is changing its physical and ecological characteristics. The changes in its environmental conditions are followed by changes in its species composition and have been recorded in historical museum collections. In this book, the biodiversity in the Mediterranean Sea is described at a synchronic or diachronic level, highlighting the past two centuries for which museum collections can provide overlooked information.
    Schlagwort(e): Mediterranean Sea ; mtDNA ; control region ; swordfish ; Monachus monachus ; Mediterranean monk seal ; mitochondrial DNA ; Adriatic Sea ; endangered species ; biodiversity ; climate change ; herbaria ; macroalgae collections ; chondrichthyans ; conservation ; fishing ; historical ecology ; Annelida ; Polychaeta ; benthos ; community structure ; algae ; environmental changes ; historical data ; benthic communities ; biomonitoring ; taxonomy ; museum collections ; environmental heritage ; marine mammals ; cetacean strandings ; natural history museums ; zoological collections ; Mediterranean biodiversity ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVG Environmental economics
    Sprache: Englisch
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  • 45
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-24
    Beschreibung: Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. The exact prevalence of endometriosis is unknown, but estimates range from 2%–10% of women of reproductive age, to 50% of infertile women. Its etiopathogenesis of endometriosis still remains controversial—immune, hormonal, genetic, and epigenetic factors may be all involved, and several theories have been proposed to explain it.This book aims to summarize recent ground-breaking studies that may open new scenarios and change the perspective of the topic, including cutting-edge elements about diagnosis, pharmacologic and surgical treatments, as well as basic/translational science (immunology, cell biology, genetics, and epigenetics) pieces of evidence, to unravel new pathways to follow for the future diagnosis and management of endometriosis, and to improve our current knowledge of its aetiology.
    Schlagwort(e): BTG1 ; endometriosis ; human endometrial stromal cells ; endometrium ; uterus ; purinergic signaling ; ATP ; pathogenesis ; genetics ; epigenetics ; immunology ; ion channels ; etiology ; CFTR ; aquaporin ; chloride channels ; biomarker ; angiogenesis ; cytokines ; urinary biomarkers ; genetic polymorphisms ; SNPs ; aetiology ; Mediterranean population ; Sardinian population ; peritoneal fluid ; microenvironment ; precision medicine ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
    Format: image/jpeg
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  • 46
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-05-06
    Beschreibung: This Special Issue focuses on the current state of pharmacogenomics (PGx) and the extensive translational process, including the identification of functionally important PGx variation; the characterization of PGx haplotypes and metabolizer statuses, their clinical interpretation, clinical decision support, and the incorporation of PGx into clinical care.
    Schlagwort(e): pharmacogenomics ; return of results ; genetic counseling ; qualitative ; pharmacogenetics ; implementation ; pharmacogenetics service ; screening ; pre-emptive ; personalized medicine ; precision medicine ; community pharmacy ; pharmacogenomic testing ; genetic privacy ; pharmaco-economics ; polymorphisms ; pharmacogenes ; pharmacogenomic ; machine learning ; adaptation ; human evolution ; US Food and Drug Administration ; clinical actionability ; clinical translation ; chronic kidney disease ; CYP3A5 ; polymorphism ; progression ; pharmacogenomics (PGx) ; pediatrics ; best practice alerts (BPAs) ; electronic health records (EHR) ; genomic indicators ; clinical decision support (CDS) ; phenotype ; genotype ; polypharmacy ; chronic disease ; medication management ; electronic medical record ; artificial intelligence ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Sprache: Englisch
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  • 47
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    Publikationsdatum: 2023-05-10
    Beschreibung: Trauma is still a leading cause of death in patients below 40 years of age. Clinical management of severely injured patients is challenging in all phases of treatment during the clinical course. Numerous factors, such as injury severity, injury pattern, patient characteristics and trauma system, affect the decision-making process in our patients. After the successful initial management of an unstable multiply injured patient, secondary definitive surgeries and reconstructions may have a risk for further systemic complications and the deterioration of the patient’s physiology. A “Safe Definitive Surgery” (SDS) concept considers the dynamics of the clinical course (prehospital, operations, complications, etc.) and the patient’s physiology. Due to the repeated re-evaluation and assessment of the patient’s clinical course, dynamics and adaptation of the treatment strategy, the safe management of polytraumatized patients is possible. Many unanswered questions still exist and need to be addressed in future studies: Which patients profit by the damage control strategy and which do not? When is it best to start with the definitive fixation of fractures in multiply injured patients? How can one improve the quality of life in polytraumatized patients? What are the strategies in elderly severely injured patients? With this Special Issue, we would like to stimulate research in the field of polytrauma in order to shed light on the above-mentioned questions
    Schlagwort(e): pelvic ring fracture ; PCCD ; position ; associated injuries ; geriatric trauma ; scoring ; polytrauma ; ISS ; AIS ; geriatric patients ; orthogeriatric ; E-bike injuries ; outcome ; injury pattern comparison ; traumatic injury ; reactive oxygen species ; phagocytosis ; CD14 ; CD16 ; CD62L ; fMLP ; PMA ; emergency surgery ; trauma team competence ; trauma system ; life-saving intervention ; trauma ; non-invasive external pelvic stabilizers ; bleeding ; pelvic fractures ; post mortem analysis ; biomechanical force ; pneumatic pelvic sling VBM® ; T-POD® ; cloth sling ; SAM Sling® ; trauma victims ; prehospital death ; Injury Severity Score (ISS) ; hemorrhage ; shock ; resuscitation ; coagulopathy ; oxygen transport ; endotheliopathy ; microcirculation ; macrocirculation ; orthopaedic trauma ; nutritional deficiencies ; vitamins ; lower extremity ; wound complications ; nutrition wound healing ; platelets ; immune system ; posttraumatic organ failure ; posttraumatic lung dysfunction ; posttraumatic hyperinflammation ; I-FABP ; biomarker ; intestinal damage ; hemorrhagic shock ; major trauma ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
    Format: application/octet-stream
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  • 48
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: In higher mammals, including primates and carnivores, the asymmetrical aspects of brain morphology and function have been shown to be species-related, sex-related, and subject to individual diversity, and are associated with cognition, emotion, language, preference of hand/paw use, and numerous other aspects. Disturbance of the brain lateralization is involved in human neurodevelopmental disorders with cognitive impairments, social deficits, and/or specific language impairments. Asymmetric development may be essential to the evolution of the brain in acquiring higher and/or more diverse functions. The purpose of this Special Issue on “Brain Asymmetry in Evolution” is to highlight morphological and functional lateralization of the brain in various species of mammals toward understanding the evolution of the brain.
    Schlagwort(e): oxyhemoglobin level ; state anxiety ; task performance ; heart rate ; human ; asymmetry ; sex difference ; MRI ; volumetry ; cerebellum ; ferret ; lateralization ; side bias ; fish ; methodological artefacts ; symmetry ; non-human primate ; Old World monkey ; evolution ; evolutionary expansion ; gyrification ; structural asymmetry ; language laterality ; topological data analysis ; persistent homology ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 49
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: Predation and scavenging are pervasive ecological interactions in both terrestrial and aquatic environments. The ecology, evolution and conservation of predators and scavengers have received wide scientific attention and public awareness. However, the close connection that exists between predation and scavenging has not been emphasized until very recently. The recognition that carnivorous animals may obtain meat by either hunting prey or scavenging their carcasses has profound implications from individual behavior to population, community and ecosystem levels. However, many relevant questions still remain unexplored. This book deals with some of these questions, with the final aim to definitively dismiss the traditional view that predation and scavenging are disconnected ecological processes. This compendium of science may help to inspire ecologists, evolutionary biologists, paleontologists, anthropologists, epidemiologists, forensic scientists, anatomists, and, of course, conservation biologists in their stimulating and promising endeavor of achieving a more comprehensive understanding of carnivory in a rapidly changing world.
    Schlagwort(e): caching ; Capreolus capreolus ; carrion ; Eurasian lynx ; Lynx lynx ; Norway ; predation ; roe deer ; scavenging ; decomposition ; nitrogen ; nutrient recycling ; trophic cascade ; apex predators ; bear ; interspecific interactions ; moose ; wolf ; birds of prey ; foraging ; predators ; scavengers ; vision ; carcass ; confrontational scavenging ; disease risk ; facultative scavenger ; landscape of peril ; marine ecosystems ; parasite risk ; predator risk ; terrestrial ecosystems ; anthropogenic food ; diet ; urban habitats ; ecological functions ; carnivorous ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere
    Sprache: Englisch
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  • 50
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: The development of civilization entails the need to find new technological solutions leading to products with new properties. Allies in these efforts are microorganisms that have developed skills to synthesize products with properties of interest to the industry, environmental remediation or water treatment. The evolution of the omics approaches brought new tools to explore the microbial diversity and microorganisms’ potential. These new methodological approaches are readily used in both industrial and environmental microbiology. This Special Issue collects research papers as well as review articles addressing recent advances on applied and environmental microbiology. The review articles critically discuss the importance of biopolymers, specifically xanthan gum, to improve soil properties and the importance that microorganisms of poorly explored environments, such as caves, may have in the production of new bioactive compounds. The microbiological aspects of wastewater treatment and occurrence of antibiotic resistance genes in wastewater and sludge are studied in two research papers. These works demonstrate the effect that treatment conditions may have in the modulation of the water bacterial communities and how treated wastewater may impact the receiving environment in terms of pollution with antibiotic resistance genes. Additionally, the influence that an invasive species (alligator weed) may have on wetlands organic matter accumulation and bacterial communities was studied, being demonstrated that the presence of the invasive weed affects the wetland microhabitat both in terms of organic matter content and bacterial communities structure.
    Schlagwort(e): Alternanthera philoxeroide ; bacterial composition ; organic matter ; wetland ; antibiotic resistance ; wastewater ; WWTP ; ARGs ; sulfonamides ; fluoroquinolones ; intermittent aeration ; TSS-rich meat-processing wastewater ; extracellular polymeric substances ; complete denitrification ; microbial structure ; karst ; methane ; carbon dioxide ; greenhouse gases ; methanotrophy ; cave bacteria ; bioactive compounds ; geotechnical engineering ; microbiology ; biopolymer ; bioclogging ; xanthan gum ; soil improvement ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 51
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: The future food systems will have to provide food and nutrition security while facing unprecedented sustainability challenges: this underlines the need for a transition to more sustainable food systems. Taking into account these premises and considering the complexity of food systems, this book aims to present original research articles, reviews, and commentaries concerning the following:Advancements in food and beverage;Dietary supplements, nutraceuticals, and functional food;Food allergy and public health;Food and nutritional toxicology;Food biotechnology and food processing;Food microbiology and food safety;Food packaging;Food safety and food inspection;Food security and environmental impacts;Food waste management;Nutrition and metabolism;Sustainable food systems and agro-ecological food production.
    Schlagwort(e): perceived consumer effectiveness ; green food consumption ; social trust theory ; social ideal theory ; psychological wellbeing ; China ; food additives ; food industry ; food safety ; health impacts ; maltitol ; metabolism ; sweeteners ; consumer’s perceptions and attitudes ; food security ; natural food products ; natural sweeteners ; sustainability ; food sovereignty ; reindeer herding ; food value chain ; Indigenous peoples ; COVID-19 pandemic ; the Arctic ; Western Siberia ; Yamal-Nenets Autonomous Okrug ; epistemic trust ; risk perception ; genetically modified food ; public acceptance ; partial least squares structural equation modeling ; community-based intervention ; diet ; home food availability ; home food environment ; sugar sweetened beverages ; fruit and vegetable intake ; Mediterranean diet ; Mediterranean diet pyramid ; sustainable diets ; environmental concerns ; nutrition ; food-based dietary guidelines ; migrants ; diabetes ; food habits ; culturally tailored diet ; transcultural mediator ; café ; green ambience ; Delphi method ; indicator design ; grain production ; spatial–temporal characteristic ; influencing factors ; the Huang-Huai-Hai Plain ; Crepis vesicaria L. subsp. taraxacifolia ; nutritional value ; phenolic profile ; chicoric acid ; antioxidant ; anti-inflammatory ; Brazil ; community restaurants ; food handlers ; food insecurity ; low-income ; COVID-19 ; families ; children ; food acquisition ; restaurants ; biofilms ; food microbiology ; dietary guidelines ; Mediterranean ; the USA ; Japan ; Argentina ; South Africa ; egg quality traits ; ginger ; immunity ; Japanese quail performance ; halal food performance ; availability ; healthy/nutritional factor ; accreditation ; clean/safe/hygiene factor ; trust ; attachment ; halal-friendly image ; retention ; muslim travelers ; Escherichia coli ; bacterial retention ; surface topographies ; meat exudate ; wipe cleaning ; conditioning film ; Cape Verde ; cereals ; metals ; dietary intake ; risk assessment ; Indigenous health ; food systems ; colonialism ; community-based ; participatory ; n/a ; dysphagia ; the elderly ; food products ; processing ; rheology ; texture ; capital endowment ; ecological cognition ; environment-friendly technology ; adoption level ; Hackman model ; environmental health ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies::JBCC4 Cultural studies: food and society
    Sprache: Englisch
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  • 52
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    Firenze University Press
    Publikationsdatum: 2022-06-02
    Beschreibung: TOX is a manual aimed primarily at the Toxicology courses of the Faculty of Pharmacy and Science, that can also be profitably utilised by students following different degree courses in other Faculties (Medicine, Agriculture, Engineering)and by anyone else looking for a thorough but succinct overview of toxicological questions. TOX covers the principal sectors of general toxicology (acute and chronic toxicity, mutagenesis, teratogenesis, carcinogenesis, reproductive toxicity, oxidative damage, epidemiological methods), specialist toxicology(dietary toxicity, tobacco smoke, pesticides, N-nitroso compounds, heterocyclic amines and aromatic amines toxicity) and environmental toxicology (environmental estrogens, PAH, heavy metals, dioxins and polychlorinated di-benzo-furans, water and air pollution).
    Schlagwort(e): Medicina ; Tossicologia ; Farmacologia ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 53
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: This text presents cutting-edge topics on and the diagnostic and therapeutic approaches for tear film abnormities, including dry eye disease and Meibomian gland dysfunction. A new management algorithm for Meibomian gland dysfunction, therapeutic eye drops and intense pulsed lasers for dry eye disease, and topical and systemic agents for neuropathic ocular pain are proposed in this issue.
    Schlagwort(e): cross-sectional study ; dry eye disease ; systemic comorbidity ; graves’ ophthalmopathy ; inflammation ; meibomian glands ; morphological changes ; meibomian gland dysfunction ; ocular surface disease ; dry eye symptoms ; questionnaire ; Bangladesh ; global health ; epidemiology ; aqueous-deficient dry eye ; meibomian gland ; intense pulsed light ; severe keratitis ; hyaluronan ; hylan A ; multicenter ; randomized trial ; gabapentin ; dry eye ; neuropathic pain ; diabetes ; neuropathic keratopathy ; neuropathy ; nerve growth ; neurotrophic ; Houttuynia ; ultrasonic atomization ; meibography ; meiboscore ; TRPM8 agonist ; cryosim-3 ; fatty acids ; vitamin D ; brief-type self-administered diet history questionnaire ; Japanese ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 54
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-06-24
    Beschreibung: Natural products or organic compounds isolated from natural sources as primary or secondary metabolites have inspired numerous drugs. It is not an overstatement that the majority of medicines in clinics, even in the 21st century, have been derived from natural resources despite the decline of industry research into natural products due to a variety of drawbacks. Saffron crocus, considered to be the most valuable spice by weight, and its bioactive constituents, have been studied for the treatment of a wide range of pathologies, including neuropsychiatric and neurodegenerative disorders, cancer, diabetes, and even cardiovascular diseases. In this book on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents, we aimed to assess new advances in the understanding of the therapeutic action of saffron and its constituents in targeting different pathologies. In this context, eight original research articles covering recent advances in the therapeutic actions of saffron and its ingredients in different diseases are reported. Two studies reporting novel methods regarding the bioanalysis of saffron extracts have been included. The collection is completed with two very interesting reviews reporting advances in the fields of schizophrenia and cancer. In conclusion, in this book, we are delighted to have received several contributions that we hope will provide new and interesting information for the scientific community on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents.
    Schlagwort(e): saffron ; affron® ; depression ; anxiety ; antioxidant ; crocins ; glucose ; β-pancreatic cells ; insulin ; pck1 ; neuroprotective activity ; P2X7 receptor ; fraction ; flumazenil ; rat ; Crocus sativus ; cancer ; anticancer activity ; chemoprevention ; clinical trials ; patents ; anesthetic ketamine ; memory ; Crocus sativus L. ; schizophrenia ; crocetin ; pubertal testis ; X-rays ; radiotherapy ; fertility preservation ; SIRT1 ; HuR ; oxidative stress ; autophagy ; crocin ; picrocrocin ; safranal ; dietary supplement ; nutraceutical ; Crocus sativus L. (Iridaceae) ; reversed-phase UPLC ; metabolomics ; HR MS ; inflammatory bowel disease ; gut microbiota ; colitis ; cytokines ; colorectal cancer ; HCT116 ; MLH1 ; MSH3 ; DNA damage and repair ; apoptosis ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 55
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-05-06
    Beschreibung: In the past few years, knowledge about glaucoma diagnosis and follow up has evolved dramatically through advances in intraocular pressure (IOP) measurement, corneal biomechanics, structural and functional assessment of the ocular surface, anterior chamber, retina, optic nerve and intracranial visual pathways, as well as the advent of artificial intelligence. In addition, the development of new modalities of IOP-lowering and non-IOP-lowering drugs, alternative deliveries, refined laser technologies, and minimally invasive glaucoma surgery (MIGS) techniques with different implants have widened the therapeutic possibilities for treating this disease. Finally, current insights into risk factors and quality of life in relation to glaucomatous impairment are emerging. The purpose of this Special Issue is to present the latest exciting clinical developments that are taking place in the field of glaucoma.
    Schlagwort(e): ripasudil ; suture trabeculotomy ab interno ; Schlemm’s canal incision ; aqueous outflow ; open-angle glaucoma ; glaucoma ; inflammation ; oxidative stress ; phenotype ; polymorphism ; susceptibility ; intraocular pressure ; ocular inflammation ; cornea biomechanics ; Corvis® ST ; subclinical keratoconus ; ocular hypertension ; tears ; miRNAs ; next generation sequencing ; biomarkers ; genes ; signaling pathways ; apoptosis ; neurodegeneration ; glaucoma suspect ; lamina cribrosa ; optical coherence tomography angiography ; peripapillary vessel density ; OCTA ; vessel density ; disc ; peripapillary ; NTG ; BRVO ; corneal hysteresis ; corneal biomechanics ; ocular biomarkers ; deep learning ; perimetry ; optic nerve ; obesity ; risk factor ; young adults ; multifocal visual evoked potentials ; mfVEP ; physical exercise ; sport ; acrobatic gymnastics ; baseline intraocular pressure ; central corneal thickness ; ocular health ; tumbling skills ; hand balance ; cytokines ; BDNF ; VEGF ; fractalkine ; microglia ; saffron ; crocin ; retinal glial cells ; microperimetry ; OCT ; macula ; structure ; function ; correlation ; retina ; inner ; outer ; macular segmentation ; optical coherence tomography-angiography ; vascular density ; blood flow ; biomarker ; myopia ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 56
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Agricultural practices involving the excessive use of chemical fertilizers and pesticides pose major risks to the environment and to human health. The development and adoption of sustainable ecofriendly agricultural management to preserve and enhance the physical, chemical, and biological properties of soils and improve agroecosystem functions is a challenge for both scientists and farmers. The Special Issue entitled “Sustainable Agricultural Practices—Impact on Soil Quality and Plant Health” is a collection of 10 original contributions addressing the state of the art of sustainable agriculture and its positive impact on soil quality. The content of this Special Issue covers a wide range of topics, including the use of beneficial soil microbes, intercropping, organic farming and its effects on soil bacteria and nutrient stocks, application of plant-based nematicides and zeolite amendments, sustainability in CH4 emissions, and the effect of irrigation, fertilization, and environmental conditions as well as land suitability on crop production.
    Schlagwort(e): natural substances ; nematicidal ; root-knot nematodes ; oregano ; soil amendments ; basic substances ; PCA ; land capability ; crop suitability ; GIS ; NWCE ; Egypt ; microbial inoculants ; soil enzyme activities ; soil microbes ; 16S rRNA ; planting pattern ; soil chemical properties ; soil microbial community ; genotype × environment interaction ; maize ; yield ; soil amelioration ; resource use efficiency ; water conservation ; nutrient retention ; heavy metal toxicity ; Cucumis melo L. ; chemical composition ; cultivar ; drip irrigation ; fruit quality ; long term field experiment ; sustainable crop production ; nutrient balances ; legume nutrition ; drained peat ; greenhouse gas ; global warming ; organic soil ; pineapple ; water table ; AMF ; enzyme activity ; microbial communities ; PGPR ; plant growth ; PLFAs ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 57
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-24
    Beschreibung: This special issue on the genetics of Alzheimer's disease was edited by Drs. Laura Ibanez and Justin Miller in 2021. It contains 10 original articles and reviews that help readers understand specific genetic contributions to Alzheimer's disease and how genetics will play a role in future Alzheimer's disease research.
    Schlagwort(e): Alzheimer disease ; expression quantitative trait loci (eQTL) ; rare variants ; set-based eQTL ; SKAT-O ; pathways ; immune system ; inflammation ; ROSMAP ; ADNI ; complement ; complement receptor 1 ; clusterin ; late-onset Alzheimer’s disease ; genetics ; neuroinflammation ; Alzheimer’s disease ; cytokines and growth factors ; genome-wide association study (GWAS) ; Polygenic Risk Score (PRS)-based analysis ; TOMM40 gene ; RNA transcription ; pseudogene ; mitochondrial dysfunction ; ITIM ; ITAM ; SIGLEC14 ; SIGLEC5 ; copy number variation ; CNV ; GWAS ; long non-coding RNA ; biomarkers ; peripheral system ; amyloid β ; tau ; APOE ; TREM2 ; OMICS ; therapeutics ; pairwise feature correlation ; feature reduction ; machine learning ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 58
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: This Special Issue is designed to celebrate the founding of the open-access journal Oceans and is focused on presenting new ideas and advances at the cutting edge of ocean science. The scope of this Special Issue includes, but is not limited to: ocean geosciences, physics, biogeochemistry, and ecology; ocean ecosystem services and sustainable ocean resource use; and ocean operations and engineering. The fifteen articles published in this Special Issue focus on diverse areas of oceanography, including ocean ecology and biology, ocean geosciences, ocean climate and meteorology, ocean circulation, ocean chemistry and biogeochemistry, ocean resources (e.g., fisheries, aquaculture, and mining), ocean engineering, ocean modeling and ocean governance.
    Schlagwort(e): SIDS ; UN Member States ; sustainable development goal 14 ; SAMOA pathway ; capacity building ; scientific infrastructure ; IAEA ; ocean challenges ; nuclear and isotopic techniques ; ecology ; oceanography ; Portugal ; abundance rate ; nursery ; common dolphin ; Delphinus delphis ; phytoplankton ; zooplankton ; time series ; regime shift ; climate ; nutrients ; composite ; delamination ; seawater ; immersion ; ageing ; Black Sea ; biogeochemical modelling ; seasonal phytoplankton and inter-annual variation ; capture–recapture ; Cayman Islands ; Seychelles ; monitoring ; endangered species ; maximum number of individuals ; photo-identification ; mark-recapture ; movement ecology ; phosphorus ; polyphosphates ; pyrophosphate ; pyrophosphatase activity ; seaweed ; Ulva ; ras al hadd oceanic dipole ; arabian sea ; cyclonic and anticyclonic eddies ; altimetric data ; angular momentum eddy detection and tracking algorithm (AMEDA) ; HYCOM model ; ARGO floats ; carbon cycle ; tropical Atlantic ; dissolved inorganic carbon ; alkalinity ; Demerara Rise ; millennial-scale variability ; Late Quaternary paleoclimate ; seafloor mapping ; vulnerable deep-sea habitats ; deep-sea corals ; chemosynthesis-based communities ; vulnerable marine ecosystem ; Atlantic Ocean ; seismic faults ; slope instabilities ; submarine volcanism ; fluid-flow processes ; bottom currents ; tsunamis ; canyon heads ; tectonic indentation ; multidisciplinary approach ; carbon ; eutrophic ; Hiroshima Bay ; nitrogen ; sulfur ; sediment ; ocean forecasting ; reflexivity ; fisheries ; harmful algal blooms ; coupled natural-human systems ; Anthropocene ocean ; shark ; luminescence ; Etmopteridae ; Dalatiidae ; Somniosidae ; photophore ; hormonal control ; counter-illumination ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 59
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: The topics of the book cover forest parameter estimation, methods to assess land cover and change, forest disturbances and degradation, and forest soil drought estimations. Airborne laser scanner data, aerial images, as well as data from passive and active sensors of different spatial, spectral and temporal resolutions have been utilized. Parametric and non-parametric methods including machine and deep learning methods have been employed. Uncertainty estimation is a key topic in each study. In total, 15 articles are included, of which one is a review article dealing with methods employed in remote sensing aided greenhouse gas inventories, and one is the Editorial summary presenting a short review of each article.
    Schlagwort(e): forest structure change ; EBLUP ; small area estimation ; multitemporal LiDAR and stand-level estimates ; forest cover ; Sentinel-1 ; Sentinel-2 ; data fusion ; machine-learning ; Germany ; South Africa ; temperate forest ; savanna ; classification ; Sentinel 2 ; land use land cover ; improved k-NN ; logistic regression ; random forest ; support vector machine ; statistical estimator ; IPCC good practice guidelines ; activity data ; emissions factor ; removals factor ; Picea crassifolia Kom ; compatible equation ; nonlinear seemingly unrelated regression ; error-in-variable modeling ; leave-one-out cross-validation ; digital surface model ; digital terrain model ; canopy height model ; constrained neighbor interpolation ; ordinary neighbor interpolation ; point cloud density ; stereo imagery ; remotely sensed LAI ; field measured LAI ; validation ; magnitude ; uncertainty ; temporal dynamics ; state space models ; forest disturbance mapping ; near real-time monitoring ; CUSUM ; NRT monitoring ; deforestation ; degradation ; tropical forest ; tropical peat ; forest type ; deep learning ; FCN8s ; CRFasRNN ; GF2 ; dual-FCN8s ; random forests ; error propagation ; bootstrapping ; Landsat ; LiDAR ; La Rioja ; forest area change ; data assessment ; uncertainty evaluation ; inconsistency ; forest monitoring ; drought ; time series satellite data ; Bowen ratio ; carbon flux ; boreal forest ; windstorm damage ; synthetic aperture radar ; C-band ; genetic algorithm ; multinomial logistic regression ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVG Environmental economics
    Sprache: Englisch
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  • 60
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Mixed cropping, also known as inter-cropping or co-cultivation, is a plant production system that involves planting two or more species (or cultivars) in the same field in a variable order—row or rowless—simultaneously. Mixed cropping plays an important role in sustainable agriculture by adding value to crop rotations and agroecosystems. Scientific investigations on environmentally friendly mixed cropping should be supported by studies on the direct costs and long-term benefits that are the most relevant to farmers. Meeting the need to strengthen the scientific basis for mixed crops, the papers in this Special Issue enhance our understanding of the following: The selection of species and cultivars for a mixed crop system as well as the choice of agricultural treatments that will secure a stable yield of mixtures; Inter- and intra- species competition of plants in a canopy; Ecological intensification approaches and opportunities for maximizing crop performance and yield in mixtures; The effects of mixed crops on crop rotations; The short- and long-term ecosystem benefits of mixtures; The effects on pests and the biodiversity of agroecosystems provided by mixtures; The economic aspects of adopting the mixtures in farms; The nutritive value of mixtures for livestock; Other topics related to the mixed cropping.
    Schlagwort(e): barley ; oats ; triticale ; yield ; leaf area index ; land equivalent ratio ; standard gross margin ; brachiaria ; cereal-livestock production ; perception ; push-pull technology ; smallholder farmers ; proximity effect ; border effect ; neighbor effect ; strip intercropping ; legume ; cereals ; Hordeum vulgare ; Lolium multiflorum ; phosphorus ; water stress ; competition indices ; plant development stages ; spring cereal mixtures ; grain yield ; protein yield ; metabolic energy yield ; differentiations of cereal mixture ; sustainable agriculture ; maize ; Zea mays L. ; biodiversity ; intercropping ; silage ; growth ; quality ; non-legume ; mixed crop ; herbivores ; pest population ; natural enemy ; cereal–legume mixture ; common vetch ; cultivar ; soil quality ; cereal-legume mixture ; organic farming ; conventional farming ; leaf greenness index ; seed yield ; yield components ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity.
    Schlagwort(e): arginine methylation ; erythroid differentiation ; MKK3 ; phosphorylation, PRMT1 ; p38 MAPK ; cocaine ; conditioned place preference ; reward ; stress ; anxiety ; depression ; nucleus accumbens ; social interaction ; k opioid receptors ; p38α ; Rab5 ; endosome ; Alzheimer’s ; Lewy Bodies ; amyloid-β ; tau ; α-synuclein ; p38-MAPK α inhibitor ; Alzheimer’s disease ; synaptic plasticity ; neuroinflammation ; β-amyloid ; Tau ; Kv4.2 ; seizure ; temporal lobe epilepsy ; hippocampus ; neuronal firing and excitability ; p38MAPK ; nuclear translocation ; β-like importins ; inflammation ; cancer ; skeletal muscle ; energy metabolism ; signal transduction ; exercise ; type 2 diabetes ; p38 mitogen-activated protein kinase ; bleomycin-induced pulmonary fibrosis ; idiopathic pulmonary fibrosis ; RNA sequencing ; alveolar epithelial type II cells ; MAPK ; p38 ; physiology ; metabolism ; signaling ; hypoxia ; arrhythmia ; MAPK11 ; p38β ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 62
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: The book collects nine original contributions in the field of integrated geophysical methods for the characterization and modeling of shallow aquifers. The first contribution introduces the following eight contributions into the overall framework of the topic. The second contribution integrates seismic and electrical techniques to define geometry and identify the transient groundwater features in a coastal alluvial aquifer. The third contribution assesses the effectiveness of electrical and electromagnetic techniques to study the geometry of a thick carbonate aquifer. The fourth contribution couples electrical techniques with implicit modeling tools to characterize the geometry and saltwater intrusion in a coastal alluvial aquifers. The fifth contribution combines electrical techniques and datasets from borehole logs to analyze the inner geometry of a gravel-bed ephemeral stream. The sixth contribution uses electromagnetic and seismic techniques to evaluate the groundwater resource in a coastal town hydrologically influenced by peri-urban irrigation agriculture. The seventh contribution uses geophysical and hydrochemical data to assess groundwater contamination in an industrial chemical complex. The eighth contribution compiles and examines different geophysical prospecting surveys of interest in groundwater research in a large urban area. The ninth contribution uses electrical and electromagnetic techniques to assess surface water and shallow groundwater salinity in a coastal groundwater-dependent ecosystem.
    Schlagwort(e): multichannel analysis of surface waves ; electrical resistivity tomography ; time-lapse inversion ; aquifer geometry ; groundwater-dependent ecosystem ; Santo André Lagoon ; Portugal ; Jurassic dolomite aquifer ; seismic reflection ; time-domain electromagnetic ; loma de Úbeda ; Spain ; managed aquifer recharge ; saltwater intrusion ; soil aquifer treatment ; sustainable development goal 6 ; deposition patterns ; climate change ; ephemeral gravel-bed stream ; borehole samples ; urban hydrogeology ; hydrogeological map ; ground penetrating radar ; groundwater resource evaluation ; Adra town ; groundwater ; contamination ; time-space ; geophysics ; hydrochemistry ; geophysical prospecting techniques ; groundwater research ; urban water supply ; Metropolitan District of Quito ; Ecuador ; Everglades National Park (ENP) ; electrical resistivity ; electromagnetism ; formation factor ; salinity and constrained inversion ; n/a ; dipole-dipole ; fractures ; saprolite ; pumping well ; Federal district of Brazil ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: In the last decade, research on cold atmospheric plasma (CAP) has significantly advanced our understanding of the effect of CAP on cancer cells and their potential for cancer treatment. This effect is due to the reactive oxygen and nitrogen species (RONS) created by plasma. This has been demonstrated for different cancer cell lines and the first clinical trials showed promising results. In addition, plasma could be combined with other treatments—such as immunotherapy—to boost its anticancer activity. The addition of new research tools to study the response of cancer cells to CAP—such as 3D in vitro, in ovo, and in vivo models and in silico approaches—as well as the use of -OMICS technologies could aid in unravelling the underlying mechanisms of CAP in cancer treatment. In order to progress towards widespread clinical application of CAP, an integrated study of the multidimensional effect of CAP in cancer treatment is essential. In this book, reviews and original research papers are published that provide new insights into the mechanisms of cold atmospheric plasma in cancer treatment, based on in vitro and in vivo experiments, clinical studies, as well as computer modeling.
    Schlagwort(e): cell adhesion ; plasma medicine ; oncology ; cold atmospheric plasma ; selectivity ; plasma-treated liquid ; dielectric barrier discharge ; pancreatic cancer ; pancreatic stellate cells ; immunogenic cell death ; dendritic cells ; cell communication ; extracellular matrix (ECM) ; reactive oxygen and nitrogen species (ROS) ; tumour microenvironment (TME) ; extracellular vesicles ; communication junctions ; three-dimensional in vitro culture models ; apoptosis ; breast cancer ; genome-wide expression ; reactive oxygen species ; anticancer drugs ; screening ; tumor spheroids ; combination therapy ; kINPen ; reactive oxygen and nitrogen species ; ROS ; cancer ; non-thermal atmospheric pressure plasma (NTP) ; indirect treatment ; plasma-treated phosphate-buffered saline ; electroporation ; electric pulses ; pulsed electric field amplitude ; melanoma ; long-lived reactive species ; bone cancer ; osteosarcoma ; reactive species ; plasma-activated liquid ; Ringer’s saline ; organotypic model ; nonthermal biocompatible plasma ; soft jet plasma ; human glioblastoma ; p38/MAPK pathway ; tissue penetration ; non-thermal plasma ; non-invasive plasma treatment (NIPP) ; cervical intraepithelial neoplasia (CIN) ; Raman imaging ; Raman microspectroscopy ; Plasma lipid interactions ; cold physical plasma ; radiation therapy ; radio-frequency discharge ; PARP-inhibitor ; olaparib ; DNA-damage ; gold quantum dots ; plasma ; nanomaterials ; cellular uptake ; invasiveness ; cold atmospheric pressure plasma ; plasma-activated Ringer’s lactate solution ; ovarian cancer ; cytotoxicity ; plasma-activated liquids ; multicellular tumor spheroids ; long-lived reactive oxygen and nitrogen species ; high frequency electrosurgery ; plasma treatment ; cold atmospheric plasma (CAP) ; free radicals ; cancer selectivity ; cervical cancer treatment ; cervical intraepithelial neoplasia ; cholangiocarcinoma ; cold plasma ; innovative therapy ; tumor cells ; macrophages ; plasma selectivity ; plasma jet ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 64
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: The devastating effects caused by the recent catastrophic earthquakes that took place all over the world from Japan, New Zealand, to Chile, as well as those occurring in the Mediterranean basin, have once again shown that ground motion, although a serious source of direct damage, is not the only parameter to be considered, with most damage being the result of coseismic geological effects that are directly connected to the earthquake source or caused by ground shaking. The primary environmental effects induced by earthquakes as well as the secondary effects (sensu Environmental Seismic Intensity - ESI 2007 scale) must be considered for a more correct and complete evaluation of seismic hazards, at both regional and local scales. This Special Issue aims to collect all contributions that, using different methodologies, integrate new data produced with multi-disciplinary and innovative methods. These methodologies are essential for the identification and characterization of seismically active areas, and for the development of new hazard models, obtained using different survey techniques. The topic attracted a lot of interest, 19 peer-reviewed articles were collected; moreover, different areas of the world have been analyzed through these methodologies: Italy, USA, Spain, Australia, Ecuador, Guatemala, South Korea, Kyrgyzstan, Mongolia, Russia, China, Japan, and Nepal.
    Schlagwort(e): Arctic–Asian seismic belt ; regional segment ; active fault ; paleoseismogenic structure ; Late Cenozoic deformation ; earthquake mechanism ; seismotectonic deformation ; potential seismicity ; earthquake hazard ; DIC ; CPO ; model selection ; Pohang earthquake ; South Korea ; ground effects ; liquefaction ; geological control ; fault barrier ; seismic hazard ; earthquake hazards ; ESI scale 2007 ; EEE database ; microtremor H/V spectral ratio ; inversion ; shear-wave velocity structure ; site amplification ; Ulaanbaatar ; earthquake environmental effects ; Suusamyr earthquake ; Kyrgyzstan ; Tien Shan ; surface rupture ; landslide ; digital elevation model (DEM) ; Structure-from-Motion ; earthquake-induced landslide ; fully probabilistic technique ; Newmark’s method ; Sakhalin Island ; risk ; machine learning ; expert estimate ; maximum possible magnitudes of earthquakes ; one class classification ; seismic zoning ; earthquake forecasting ; paleoliquefaction ; paleoearthquake ; ESI-07 scale ; earthquake environmental effects (EEEs) ; earthquake archaeological effects (EAEs) ; intensity maps ; seismic scenarios ; earthquake catalogues ; Spain ; emergency shelter ; earthquake ; disaster ; weighted coefficient ; suitability analysis ; geographic information systems (GIS) ; catalog incompleteness ; coseismic landslides ; macroseismic intensity ; Pedernales earthquake ; Ecuador ; georisk ; probabilistic seismic hazard ; ESI scale ; ground-shaking map ; Guatemala ; Intraplate earthquake ; Australian earthquakes ; reverse earthquake ; ESI 2007 scale ; historical and recent earthquakes ; attenuation ; GMPE ; crustal model ; MMI ; intraplate region ; mass movements ; inventory map ; amalgamation ; earth observation (EO) ; spatial resolution ; in situ tests ; laboratory tests ; soil liquefaction ; cyclic triaxial tests ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 65
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: This book collects contributions to the Special Issue entitled "Symmetries in Quantum Mechanics and Statistical Physics" of the journal Symmetry. These contributions focus on recent advancements in the study of PT–invariance of non-Hermitian Hamiltonians, the supersymmetric quantum mechanics of relativistic and non-relativisitc systems, duality transformations for power–law potentials and conformal transformations. New aspects on the spreading of wave packets are also discussed.
    Schlagwort(e): non-Hermitian quantum dynamics ; unitary vicinity of exceptional points ; degenerate perturbation theory ; Hilbert-space geometry near EPs ; relativistic wave equation ; Klein–Gordon equation ; Dirac equation ; Proca equation ; supersymmetry ; quantum mechanics ; shape invariance ; curved space ; position-dependent mass ; supersymmetric quantum mechanics ; self-adjoint extensions ; infinite square well ; contact potentials ; power-law duality ; classical and quantum mechanics ; semiclassical quantization ; quark confinement ; spreading wave function ; scattering ; localization ; Klein–Gordon oscillator ; Green’s function ; semiclassical theories and applications ; classical general relativity ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Biosensors are analytical devices capable of providing quantitative or semi-quantitative information by using a biological recognition element and a transducer. Depending upon the nature of the recognition element, different surface sensitive techniques can be applied to monitor these molecular interactions. In order to increase sensitivities and to lower detection limits down to even individual molecules, nanomaterials are promising candidates. This is possible due to the potential to immobilize more bioreceptor units at reduced volumes and their ability to act as transduction elements by themselves. Among such nanomaterials, gold nanoparticles, quantum dots, polymer nanoparticles, carbon nanotubes, nanodiamonds, and graphene are intensively studied. Biosensors provide rapid, real-time, accurate, and reliable information about the analyte under investigation and have been envisioned in a wide range of analytical applications, including medicine, food safety, bioprocessing, environmental/industrial monitoring, and electronics. A variety of biosensors, such as optical, spectroscopic, molecular, thermal, and piezoelectric, have been studied and applied in countless fields. In this book, examples of spectroscopic and optical biosensors and immunoassays are presented. Furthermore, two comprehensive reviews on optical biosensors are included
    Schlagwort(e): brain tumour diagnosis ; classification ; forward feature extraction algorithm ; intraoperative use ; Raman spectroscopy ; Raman probe ; SERS on ultrafine solid supports ; glass coverslips ; BPE ; thiol-DNA probe ; annealed gold nanostructures ; Brucella abortus ; Brucella melitensis ; Brucella suis ; optical fiber ; biosensor ; nucleotide probe ; light transmission ; diagnosis ; silver nanoparticles ; synthesis ; coating ; alloy ; core@shell ; LSPR ; biosensors ; water pollution ; environmental water ; drinking water ; milk ; heavy metal ions ; detection limits ; optical spectroscopy ; proteins ; functional nucleic acids ; flow-through immunoassay ; lateral flow immunoassay ; food allergen ; multiplex ; smartphone analysis ; carbon nanoparticle labeling ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-07-06
    Beschreibung: Reactive oxygen species (ROS) are produced by healthy cells and are maintained at physiological levels by antioxidant systems. However, when ROS increase in number, a condition of oxidative stress occurs, leading to many human diseases, including cancer. The relationship between oxidative stress and cancer is complex since ROS play a double-edged role in cancer development and under therapy response. This paradox represents a great challenge for researchers and needs to be investigated. The articles collected in this Special Issue can help to clarify the role of ROS modulation in cancer prevention and treatment, and to dissect the molecular mechanisms underlying its paradoxical role in order to counteract carcinogenesis or enhance sensitivity to anticancer therapy.
    Schlagwort(e): sonodynamic therapy ; carbon doped titanium dioxide ; sonosensitizers ; ultrasound ; cancer treatment ; breast cancer treatment ; radiotherapy ; hematological malignancies ; oxidative stress ; lymphoma ; leukemia ; multiple myeloma ; apoptosis ; mitochondria ; ultraviolet-C (UVC) ; withanolide ; combined treatment ; oral cancer ; DNA damage ; cancer therapy ; immune system ; Hypericum perforatum ; hyperforin ; reactive oxygen species ; pH regulation ; tumor prevention ; tumor therapy ; cancerogenesis ; inflammatory signaling ; natural compounds ; pancreatic cancer ; antitumor agents ; coordination polymers ; bioinorganic chemistry ; cold atmospheric plasma ; reactive oxygen and nitrogen species ; nitrite ; cancer stem cells ; chemoresistance ; glutathione ; lipid peroxidation ; ZEB-1 ; GPX4 ; ferroptosis ; HO-1 ; Nrf2 ; cancer progression ; patients ; therapy ; prognosis ; biomarker ; Eprenetapopt ; Erastin ; glutathione (GSH) ; SLC7A11 ; iron ; NRF2 ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Sprache: Englisch
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  • 68
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-03-21
    Beschreibung: This book includes articles written by over 80 specialists from many countries that demonstrate the biological functions of ultrasonic vocalizations and how they are used in studies of vocal expression of emotional states and in numerous animal models of neuropsychiatric diseases and disorders. Results of investigations of emissions of ultrasonic vocalizations are useful in studies of emotional disturbances, affective disorders, autism spectrum disorders, addiction, developmental abnormalities, and many other pathologies.
    Schlagwort(e): ultrasonic vocalization ; maternal immune activation ; autism ; communication ; rat ; sex differences ; social play ; rats ; anxiety ; observational fear learning ; USV ; maternal separation ; pup ; vasopressin antagonists ; righting reflex ; negative geotaxis ; ACTH ; corticosterone ; Brattleboro rat ; larynx ; female ; male ; 50-khz ultrasonic vocalizations (USVs) ; individual differences ; chronic variable stress (CVS) ; dopamine ; nucleus accumbens ; microdialysis ; evolution of vocalization ; 22 kHz calls ; 50 kHz calls ; infant isolation calls ; emotional arousal ; mesolimbic dopaminergic system ; mesolimbic cholinergic system ; hedonia ; ultrasonic vocalizations ; cognitive development ; respiration ; brain oscillations ; Cav1.2 ; calcium ; animal model ; rough-and-tumble play ; social approach ; playback ; social contact call ; alarm call ; social buffering ; distress ; emotional contagion ; fear contagion ; aversive state ; automated scoring ; addiction ; mental health ; machine learning ; drug discovery ; drug development ; Parkinson’s disease ; alpha-synuclein ; 6-OHDA ; Pink1 ; DJ1 ; exercise ; pharmacology ; pathology ; hypervigilance ; hyperreactivity ; exaggerated reactivity ; generalization ; PTSD ; depression ; heart rate ; Wistar ; 22-kHz calls ; 50-kHz calls ; affect ; aversion ; NOR ; reward ; working memory ; Y maze ; opioids ; fentanyl ; self-administration ; play ; food ; dam–pup interaction ; ethanol ; pup isolation ; rat pup ; 50 kHz vocalizations ; 22 kHz vocalizations ; amphetamine ; chemogenetics ; clozapine-n-oxide ; UMAP ; males ; females ; vocalizations ; fear extinction ; pain ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 69
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: The tendency for climate to change has been one of the most surprising outcomes of the study of Earth's history. Marine geoscience can reveal valuable information about past environments, climates, and biota just before, during and after each climate perturbation. Particularly, certain intervals of geological records are windows to key episodes in the climate history of the Earth–life system. Ιn this regard, the detailed analyses of such time intervals are challenging and rewarding for environmental reconstruction and climate modelling, because they provide documentation and better understanding of a warmer-than-present world, and opportunities to test and refine the predictive ability of climate models. Marine geological dynamics such as sea-level changes, hydrographic parameters, water quality, sedimentary cyclicity, and (paleo)climate are strongly related through a direct exchange between the oceanographic and atmospheric systems. The increasing attention paid to this wide topic is also motivated by the interplay of these processes across a variety of settings (coastal to open marine) and timescales (early Cenozoic to modern). In order to realize the full predictive value of these warm (fresh)/cold (salty) intervals in Earth's history, it is important to have reliable tools (e.g., integrated geochemical, paleontological and/or paleoceanographic proxies) through the application of multiple, independent, and novel techniques (e.g., TEX86, UK’37, Mg/Ca, Na/Ca, Δ47, and μCT) for providing reliable hydroclimate reconstructions at both local and global scales.
    Schlagwort(e): microfacies types ; Pantokrator Limestones ; Vigla Formation ; Senonian calciturbidites ; Eocene brecciated limestones ; carbonate porosity ; petroleum prospectivity ; stratigraphic correlations ; marine biogenic carbonates ; depositional environment ; paleoceanographic evolution ; planktonic foraminifera ; pteropods ; stable isotopes ; sea surface temperature (SST) ; stratification ; productivity ; sapropel S1 ; Aegean Sea ; Late Quaternary ; shell weight ; climate variability ; sea surface density ; carbonate production ; X-ray microscopy (μCT) ; δ18O and Mg/Ca analyses ; offshore groundwater exploration ; coastal aquifers ; salt-/fresh-water relationship ; Mediterranean Sea ; Attica-Greece ; cleaning protocol ; unconsolidated core sediments ; climate reconstruction ; synchrotron X-ray microtomography (SμCT) ; foraminiferal-based proxies ; BTEX natural attenuation ; hydro-stratigraphy ; multi-layered aquifer ; Thriassion Plain ; confined and unconfined aquifer ; coastal aquifer ; Gulf of Eleusis ; ocean paleodensity ; Atlantic Meridional Circulation (AMOC) ; planktonic foraminiferal biogeography ; surface sediments ; morphometrics ; shell size ; environmental biomonitoring ; ecological optimum conditions ; primary productivity ; depth habitat preference ; cryptic speciation ; central Mediterranean hydrodynamics ; sea level fluctuations ; soluble substances ; coastal environment change ; diatom ; geochemical elements ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-03-21
    Beschreibung: This book includes 17 papers published in the Special Issue/Article Collectoin “New Insights in the Genetics and Genomics of adrenocortical tumors and pheochromocytomas” including an editorial, 10 research papers and six review articles. Adrenal tumors represent a hot topic in contemporary endocrine oncology. Significant advancements in the genetics of genomics of these tumors have been made in recent years, and these articles give a useful and comprehensive overview of these issues. Questions regarding molecular pathogenesis, diagnosis (biomarkers) and even treatment are discussed in the papers written by international leaders of the field. Manuscripts are focused on three main topics: i. primary aldosteronism (the most common cause of secondary endocrine hypertension), ii. adrenocortical cancer and iii. pheochromocytoma/paraganglioma, which are the tumors with the highest heritability in humans. The book is edited by Prof. Peter Igaz (Department of Endocrinology, Faculty of Medicine, Semmelweis University).
    Schlagwort(e): pheochromocytoma ; paraganglioma ; genetics ; non-coding RNA ; malignancy ; biomarker ; treatment ; adaptive metabolism ; adrenal gland ; conn adenoma ; fatty acid metabolism ; ferroptosis ; hyperaldosteronism ; metabolic reprogramming ; β-oxidation ; PPARα ; tumor microenvironment ; Next Generation Sequencing ; hereditary cancer ; endocrine tumor syndrome ; KCNJ5 somatic mutation ; pulse wave velocity ; aldosterone-producing adenoma ; adrenalectomy ; propensity score matching ; arterial stiffness ; pheochromocytomas ; paragangliomas ; mutations ; susceptibility genes ; driver mutations ; hereditary ; germline ; somatic ; environment ; variants ; tumor suppressor genes ; metastatic ; RNAseq ; next generation sequencing ; adrenocortical carcinoma ; in silico analysis ; machine learning ; bioinformatic clustering ; biomarker prediction ; aldosterone producing adenoma ; ATP2B3 ; K416-F418delinsN mutation ; primary aldosteronism ; PPGL ; telomeres ; TERT ; ATRX ; NOP10 ; prognostic biomarker ; ALT ; phaeochromocytoma ; cancer ; mitochondrial complex II ; zebrafish ; therapy ; drug discovery ; redox balance pathway ; Vitamin C ; mitotane ; H295 strains ; microRNA ; aldosterone ; circulating ; adrenocortical ; transcriptomics ; epigenetics ; metabolomics ; epidemiology ; genetic analysis ; mortality ; surveillance ; TP53 R337H ; genetic testing ; adrenocortical tumor ; neonatal screening ; screening ; adenoma ; adrenal ; tissue ; artificial intelligence ; neural network ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 71
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: The transport sector, which is currently almost completely based on fossil fuels, is one of the major contributors to greenhouse gas emissions. Heading towards a more sustainable development of mobility could be possible with more energy efficient automotive technologies such as battery electric vehicles. The number of electric vehicles has been increasing over the last decade, but there are still many challenges that have to be solved in the future. This Special Issue “Prospects for Electric Mobility: Systemic, Economic and Environmental Issues” contributes to the better understanding of the current situation as well as the future prospects and impediments for electro mobility. The published papers range from historical development of electricity use in different transport modes and the recent challenges up to future perspectives.
    Schlagwort(e): electricity ; transportation ; e-mobility ; CO2 emissions ; decarbonization ; marginal cost ; sustainability ; V2G ; bidirectionally chargeable electric vehicles ; smart charging ; unmanaged charging ; spot markets ; day-ahead market ; intraday auction ; continuous intraday trading ; mixed integer linear optimization ; revenues potentials of EVs ; electric mobility ; charging strategies ; economics ; promotion policies ; mixed-integer optimization ; flexible systems ; charging infrastructure ; load management ; battery electric vehicle ; urban area ; multi-apartment building ; zero emission mobility ; private charging ; second life of batteries ; electromobility ; battery energy system storage ; ancillary service ; frequency regulation ; economic evaluation ; electric vehicle ; life cycle assessment ; AC charging ; DC charging ; economic assessment ; mountain rescue operations ; emergency response ; multi-method-research ; best–worst scaling ; shared parking ; sharing economy ; P + R car park ; low-power chargers ; battery electric vehicles ; public transport ; emissions ; policies ; distributed energy systems ; cost- and GHG emission minimization ; environment ; passenger cars ; mobility-as-a-Service ; electric vehicles ; e-car sharing ; e-scooter sharing ; sustainable mobility ; suburban area ; choice-based conjoint ; latent class analysis ; willingness to pay ; market simulations ; genetic algorithm ; V2G services ; valley filling ; peak shaving ; flexibility ; motorized private transport ; modelling electricity demand ; driving patterns ; electricity demand profile ; transport ; electricity sector ; demand side integration ; total system costs ; COVID-19 pandemic ; transportation modeling ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 72
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Recently, there has been a growing awareness of the need to make better use of natural resources. Hence, the utilization of biomass has led to so-called biorefinery, consisting of the fractionation or separation of the different components of the lignocellulosic materials in order to achieve a total utilization of the same, and not only of the cellulosic fraction for paper production. The use of plant biomass as a basic raw material implies a shift from an economy based on the exploitation of non-renewable fossil fuels, with limited reserves or with regeneration cycles far below the rates of exploitation, to a bioeconomy based on the use of renewable organic natural resources, with balanced regeneration and extraction cycles. To make this change, profound readjustments in existing technologies are necessary, as well as the application of new approaches in research, development, and production."Biorefinery" is the term used to describe the technology for the fractionation of plant biomass into energy, chemicals, and consumer goods. The future generation of biorefinery will include treatments, leading to high-value-added compounds. The use of green chemistry technologies and principles in biorefineries, such as solvent and reagent recovery and the minimization of effluent and gas emissions, is essential to define an economically and environmentally sustainable process.In particular, the biorefinery of lignocellulosic materials to produce biofuels, chemicals and materials is presented as a solid alternative to the current petrochemical platform and a possible solution to the accumulation of greenhouse gases.
    Schlagwort(e): lignocellulosic biomass ; solid-state fermentation ; enzymatic hydrolysis ; aerated bioreactor ; Aspergillus oryzae ; lignin ; lignocellulose ; aromatics ; biobased ; epoxy ; fatty acid ; biopolymers ; biobased materials ; biorenewable ; bio-based filament ; 3D printing ; sugarcane bagasse pulp ; barley straw ; composite ; flexural strength ; biobased polyethylene ; nanocellulose ; β-cyclodextrin ; cryogels ; films ; biomaterials ; cellulose ; dialdehyde cellulose ; organosilane chemistry ; 29Si NMR ; solid state NMR ; silanization ; lignocellulose valorization ; ‘lignin-first’ ; reductive catalytic fractionation ; lignocellulose nanofibers ; horticultural residues ; paperboard ; recycling ; biosurfactants ; enzymatic saccharification ; fermentation ; quinoa saponins ; steam-pretreated spruce ; lignocellulosic material ; xylose ; furfural ; iron chloride ; microwave reactor ; biorefinery ; electrosynthesis ; biomass ; carbohydrate ; saccharides ; electro-oxidation ; electroreduction ; residue ; agro-industry ; high-value products ; banana ; torrefaction ; Jerusalem artichoke ; biofuel ; energy crops ; agiculture ; micro-fibrillated cellulose ; formaldehyde adhesives ; wood-based panels ; kraft lignin ; adsorbent material ; copper adsorption ; H2S adsorption ; H2S removal ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 73
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Proteins represent one of the most abundant classes of biological macromolecules and play crucial roles in a vast array of physiological and pathological processes. The knowledge of the 3D structure of a protein, as well as the possible conformational transitions occurring upon interaction with diverse ligands, are essential to fully comprehend its biological function.In addition to globular, well-folded proteins, over the past few years, intrinsically disordered proteins (IDPs) have received a lot of attention. IDPs are usually aggregation-prone and may form toxic amyloid fibers and oligomers associated with several human pathologies. Peptides are smaller in size than proteins but similarly represent key elements of cells. A few peptides are able to work as tumor markers and find applications in the diagnostic and therapeutic fields. The conformational analysis of bioactive peptides is important to design novel potential drugs acting as selective modulators of specific receptors or enzymes. Nevertheless, synthetic peptides reproducing different protein fragments have frequently been implemented as model systems in folding studies relying on structural investigations in water and/or other environments.This book contains contributions (seven original research articles and five reviews published in the journal Molecules) on the above-described topics and, in detail, it includes structural studies on globular folded proteins, IDPs and bioactive peptides. These works were conducted usingdifferent experimental methods.
    Schlagwort(e): mass spectrometric epitope mapping ; gas phase immune complex dissociation ; apparent gas phase dissociation constants ; apparent gas phase activation energies ; ITEM-TWO ; native mass spectrometry ; TRIOBP ; cancer ; deafness ; hearing loss ; mental illness ; schizophrenia ; actin ; cytoskeleton ; disordered structure ; protein aggregation ; solid-state NMR ; ELDOR-detected NMR ; ATP hydrolysis ; ATP analogues ; DnaB helicase ; ABC transporter ; biopesticides ; antifungal activity ; insecticidal activity ; mechanism of action ; transgenic crops ; protein folding ; NMR ; High Hydrostatic Pressure ; ACE2 ; viral spike receptor-binding domain ; SARS-CoV-2 ; transmission ; bioinformatics ; IDP 1 ; binding 2 ; molecular dynamics 3 ; MELD×MD 4 ; advanced sampling 5 ; p53 6 ; MDM2 7 ; NAD(P)H-dependent oxidoreductase ; zinc-containing alcohol dehydrogenase ; cofactor binding and release ; interdomain cleft dynamics ; molecular dynamics simulations ; denatured state ensemble ; protein coil library ; peptides ; intrinsically disordered proteins ; ion-pairing interaction ; side-chain length ; charged amino acids ; β-hairpin ; peptide ; Friedman’s test ; backbone atom coordinate variances and uncertainties ; superimposition ; nanobody ; protein structure ; immunoglobulin domain ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 74
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: In recent years, the methodologies of teaching have been in a process of transition. Multiple active methodologies have proliferated, with the aim of changing the concept we have had of teaching so far. These advocate for a student who plays a leading role in the process of building learning, while the teacher acts as a figure who facilitates and glimpses the paths to learning. In order to be able to carry out this type of teaching in an optimal way, it is necessary for the teaching and research community to be correctly trained in its pedagogical principles and in the tools that boost its implementation. Among these principles and tools, it is of vital importance that information and communication technologies (ICT) be adequately handled. The use of active methodologies (project-based learning, problem-based learning, service learning, flipped classroom, mobile learning, etc.) or innovative pedagogical approaches (simulation, role-playing, gamification, etc.) promotes an improvement in the motivation of students as well as their skills. This aspect is especially important in the area of mathematics, whose contents are characterized by their abstraction, thus highlighting the need for its dynamization in classrooms of different educational stages.
    Schlagwort(e): emerging methodology ; educational innovation ; e-learning ; educational experimentation ; adults ; students ; b-learning ; ICT ; vocational training ; constructivism ; mathematics learning ; MOOC ; new teaching techniques ; students’ access to MOOC ; learning ; reading comprehension ; complexity ; problem-solving ; arithmetic word problems ; fraction operator ; technological environment ; active methodology ; escape room ; gamification ; methodological contrast ; mathematics ; secondary education ; musical activities ; learning-teaching ; preschool ; mathematical modeling ; modeling projects ; elementary school ; learning opportunities ; computational thinking ; STEAM education ; leisure-time education ; mathematical education ; good practices in mathematics education ; mathematics achievement ; influencing factors ; university ; social sciences ; structural equation modelling (SEM) ; Flipped Classroom ; flipped learning ; higher education ; educational robotics ; active learning ; case studies ; videogame ; early childhood education ; education ; learning environments ; educational games ; engineering students ; augmented reality ; spatial intelligence ; STEM ; Geogebra AR ; teaching differential equations ; teaching mathematics ; solving problem ; formative assessment ; teacher education ; teachers’ knowledge ; game-based learning ; affective domain ; mathematics education ; systematic review ; EXPLORIA ; STEAM ; active methodologies ; university level ; afective domain ; mathematical teaching methodologies ; educative innovation ; learning through video games ; real-valued functions ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 75
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: The school of thought surrounding the urban ecosystem has increasingly become in vogue among researchers worldwide. Since half of the world’s population lives in cities, urban ecosystem services have become essential to human health and wellbeing. Rapid urban growth has forced sustainable urban developers to rethink important steps by updating and, to some degree, recreating the human–ecosystem service linkage.Assessing as well as estimating the losses of ecosystem services can denote the essential effects of urbanization and increasingly indicate where cities fall short. This second book on urban ecosystem services contains 11 thoroughly refereed contributions published within the Special Issue “Urban Ecosystem Services II: Toward a Sustainable Future”. The book addresses topics such as cultural ecosystem services, green infrastructure, urban trees, urban green spaces, and more. The contributions highlight current knowledge, gaps, and future research with the focus on building a sustainable future.
    Schlagwort(e): urban biodiversity ; urban watersheds ; Bogota Colombia ; corruption ; Unwillingness to Invest ; natural capital ; blue-green infrastructure ; urban environmental challenges ; Global South ; tropical cities ; urban forestry ; cultural ecosystem services ; public survey ; tree maintenance ; urbanization ; birds ; ecosystem services ; survival ; adaptations ; traits ; land-based financing ; land monetisation ; policy ; infrastructure ; Sustainable Development Goals ; compensation measures ; urban resilience ; urban development ; impact assessment ; cityscape visual perception ; green infrastructure ; linear parks ; sustainable landscape planning ; tram lanes ; Warsaw ; ecosystem service value ; farmland loss ; construction land expansion ; remote sensing ; landscape architecture ; design ; evaluation ; urban ecosystem services ; urban tree planting ; i-Tree Canopy ; Office for National Statistics ; health damage costs ; United Kingdom ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere
    Sprache: Englisch
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  • 76
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-06-21
    Beschreibung: People who have chronic diseases spend a significant amount of time in self-management in out-of-hospital environments, in their homes and in their community settings. These patients have different disease statuses and management requirements, so providing personalized care is key.Personalized care is a collaborative process that should be used in chronic condition management in which patients, caregivers, and healthcare providers identify and discuss problems caused by or related to the patient's condition and then develop plans and goals to empower patients.Personalized care can improve aspects of physical health, mental health, and the ability to self-manage conditions. Thus, a personalized care approach could greatly benefit patients with chronic conditions.In this book, we have included 20 articles that expand the current knowledge on the personalized care approach to diagnosing and treating chronically ill patients.
    Schlagwort(e): fibromyalgia ; physical functioning ; obesity ; pain catastrophizing ; pain acceptance ; chronic pain ; rehabilitation ; clinical psychology ; performance-based test ; dual-tasking ; cognitive function ; postural control ; older adults ; Parkinson disease ; personalized medicine ; clinical exercise ; exercise prescription ; boot camp ; physiotherapy ; compliance ; qualitative ; empowerment ; medication acceptability ; intentional nonadherence ; decision ; self esteem ; pharmacology ; rheumatology ; autoimmune ; adolescent ; nursing ; review literature ; sexuality ; virtual reality ; pain ; fatigue ; quality of life ; meta-analysis ; temporomandibular disorders ; surface electromyography ; aerobic exercise ; therapeutic exercise ; diabetes mellitus ; SGLT-2 inhibitors ; antidiabetic agents ; cardiovascular outcomes ; personalized therapy ; sleep ; chronic liver disease ; informal caregiver ; caregiver ; bibliometrics ; data analysis ; needs ; intervention ; patient-focused care ; aged ; disease prevention ; health promotion ; nursing education ; nursing students ; mental disorders ; mental illness ; social stigma ; students ; ageism ; stereotyping ; prejudice ; discrimination ; assessment ; aging ; stroke ; ischemia ; biomarkers ; mortality risk ; patient adherence ; glaucoma ; personalized care ; patient compliance ; child ; child abuse ; maltreatment ; neglect ; risk factors ; family ; caregivers ; child protective services ; advanced nursing practice ; rehabilitation nursing ; transitional care ; hospital discharge ; continuity of care ; hip fracture ; older person ; returning home ; safety ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Sprache: Englisch
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  • 77
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-01
    Beschreibung: This Special Issue covers original and innovative basic research regarding the anti-inflammatory potential of several classes of secondary metabolites (i.e., polyphenols, phytosterols, proteoglycans, and polysaccharides) in manifestations of acute and chronic inflammation in both in vitro and in vivo experimental models.
    Schlagwort(e): laminarin ; aging ; transient cerebral ischemia ; neuroprotection ; oxidative stress ; neuroinflammation ; marine-derived fungi ; anti-inflammation ; anti-neuroinflammation ; PTP1B ; marine biocompounds ; neurodegeneration ; Alzheimer’s disease ; Parkinson’s disease ; Bacillus sp. ; proteoglycan ; macrophages ; Padina boryana ; RAW 264.7 macrophages ; Nrf2/HO-1 ; MAPK ; NF-κB ; P. oceanica ; inflammation ; pain ; CD-1 mice ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 78
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: This book covers recent trends in all aspects of basic and applied scientific research on marine skeletal proteins and biopolymers (e.g., chitin, collagen), and their derivatives. Some recent innovations of marine proteins have been incorporated in this book that could be potentially applied in scientific and industrial research. Due to their broad array of biological functions in biopolymer- and protein-based drugs, such as anticancer, antimicrobial, bone tissue regeneration, antioxidant, and anti-aging functions, bioactive skeletal proteins and biopolymers have recently attracted a great amount of interest in the pharmaceutical, nutraceutical, and cosmeceutical industries (including anti-aging drugs).
    Schlagwort(e): Thunnus obesus ; collagen ; isoelectric precipitation ; physicochemical properties ; proliferation and migration ; red stingray (Dasyatis akajei) ; cartilage ; peptide ; antioxidant activity ; lung cancer ; nereis active protease ; H1299 cells ; PI3K/AKT/mTOR pathway ; benzyl glycidyl ether ; epoxide hydrolase ; enantioselective ; marine microorganism ; fish skin ; structure ; functional properties ; thermal properties ; rheology properties ; chitin ; scaffolds ; pigmental cells ; demosponges ; Ianthella ; bromotyrosines ; decamethoxine ; drug delivery ; gelatin ; marine gastropod ; Black Sea ; acidic and enzymatic extraction ; biocompatibility ; cytokines ; Lophius litulon skin ; pepsin-solubilized collagen ; characterization ; biological materials ; electrolysis ; Antipatharia ; black corals ; Cirrhipathes sp. ; sponges ; 3D scaffolds ; AgNPs ; antibacterial properties ; Aplysina aerophoba ; sponge ; osculum size ; respiration ; clearance rate ; depth ; Chondrosia reniformis ; integrated multitrophic aquaculture ; collagen fibers ; scaffold ; biomedical device ; Nibea japonica ; swim bladder ; marine collagen peptides ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 79
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Mitochondria play an increasingly central role in the context of cellular physiology. These organelles possess their own genome (mtDNA), which is functionally coordinated with the nuclear genome. Mitochondrial gene expression is mediated by molecular processes (replication, transcription, translation, and assembly of respiratory chain complexes) that all take place within the mitochondria. Several aspects of mtDNA expression have already been well characterized, but many more either are under debate or have yet to be discovered. Understanding the molecular processes occurring in mitochondria also has clinical relevance. Dysfunctions affecting these important metabolic ‘hubs’ are associated with a whole range of severe disorders, known as mitochondrial diseases. In recent years, significant progress has been made to understand the pathogenic mechanisms underlying mitochondrial dysfunction; however, to date, mitochondrial diseases are complex genetic disorders without any effective therapy. Current therapeutic strategies and clinical trials are aimed at mitigating clinical manifestations and slowing the disease progression to improve the quality of life of patients. The goal of the Special Issue ‘Mitochondria: from Physiology to Pathology’ published in Life (ISSN: 2075-1729) was to collect research and review articles covering the physiological and pathological aspects related to mtDNA maintenance and gene expression, mitochondrial biogenesis, protein import, organelle metabolism, and quality control.
    Schlagwort(e): atherosclerosis ; carotid intima-media thickness ; mitochondrial mutations ; cardiovascular risk factors ; mitochondria ; mtDNA ; cristae ; mitochondrial fission ; mitochondrial fusion ; mitochondrial diseas ; mitochondrial dynamics ; mitoenergetics ; mitosteroidogenesis ; LH ; cAMP ; Leydig cell ; mitochondrial DNA segregation ; heteroplasmy ; selective elimination ; mitophagy ; mitochondrial engineered nucleases ; kinases ; phosphorylation ; disease ; PINK1 ; Parkinson’s disease ; mitochondria homeostasis ; Cterm ; MELAS ; transmitochondrial cybrids ; aminoacyl-tRNA synthetases ; LARS2 ; mitochondrial disease ; therapeutic peptides ; FAD synthase ; FAD1 ; mitochondria localization ; Saccharomyces cerevisiae ; mRNA ; mitochondrial localization motif ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 80
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: This special issue of JCM ‘The Prevention and Treatment of Atherosclerosis’ will walk the Readers across novel diagnostic achievements in atherosclerosis and contemporary actions towards optimizing therapy.Everything begins with diagnosis. Accurate diagnostic tools and tests are of utmost importance. Contemporary research on microparticles, non-coding RNAs, proteomic characterization, …, offers detailed molecular characteristics of athero-thrombosis.Prevention is equally important as treatment. The impact of eating habits in prophylaxis of many pathologies, including cardiovascular disease has been documented.Then new pharmacological agents. Managing hypercholesterolemia with PCSK9 inhibitors, shown great potential in efficient lipid lowering to achieve LDL-C treatment goals, as well as reduction in cardiovascular mortality and morbidity.However, therapeutic goals accomplishment requires supervision. Arising number of data support that cardiovascular risk prediction can be improved with imaging modalities displaying atheroma: carotid plaque ultrasonography, coronary calcium score, intravascular ultrasonography, and optical coherent tomography or many others.As atherosclerosis is a progressive disease, it comes the time for more radical management, including endovascular and surgical intervention. There is field for new stent and equipment technologies, new surgical and endovascular techniques, supervision of endovascular procedures with IVUS, OCT, functional flow assessment or cell therapy.From diagnosis to risk stratification, elaborated prevention models, finally to modern and optimized therapeutic intervention.
    Schlagwort(e): familial hypercholesterolemia ; genetic screening ; atherosclerosis prevention ; early detection ; atherosclerosis ; cigarette smoking ; miR-27b ; peripheral artery disease ; subclinical atherosclerosis ; SCORE ; Framingham ; QRISK ; PROCAM ; cardiovascular risk ; pulse wave velocity ; intima media thickness ; malondialdehyde low-density lipoprotein ; high-risk plaque ; coronary computed tomography angiography ; statin ; cardiovascular risk factors ; heart failure ; major cardiac and cerebral ischemic events ; degenerative aortic stenosis ; risk stratification ; vascular resistance ; cardiovascular disease ; acute myocardial infarction ; intravascular imaging ; statins ; control-theoretic model ; logistic growth ; coronary artery disease ; fibrin clot ; fibrinolysis ; thromboembolism ; carotid intima-media complex ; carotid plaque ; major adverse cardiac and cerebral events ; prevention ; scores ; vitamin D ; myocardial infarction ; males ; Coronary Artery Surgery Study Score ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 81
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Since the 1990s, food chemistry opened a new chapter in foods and plants investigation. An increasing attention to secondary metabolites and micro-constituents of nutraceutical interest present in foods has been noticed, supporting previous studies on macronutrient composition. Thanks to positive scientific opinions on the presence of bioactive molecules in plants and foods, the previous vision of exploring foods exclusively from a “caloric” point of view has been changed to looking at foodstuffs as having positive effects on human health.This book focuses on the optimization and validation of advanced analytical methodologies dedicated to the characterization and valorization of foods and plants containing bioactive molecules. Qualitative and quantitative characterization, food security, traceability, and innovation in the field of nutraceutical and functional nutrition will be of particular interest in order to stimulate a dialogue on correct nutrition concepts in a constantly changing cultural, technological, and climate context.
    Schlagwort(e): HPTLC-MS coupling ; HPTLC ; negative ion DESI-HR-MS/MS ; anthraquinones ; Chilean mushrooms ; genus Cortinarius ; millet starch ; edible film ; Clove ; GC-MS ; beetroot ; lactic acid bacteria ; betalains ; functional food products ; NMR ; metabolomics ; Brassica oleracea (var. italica) ; organic and conventional pratices ; glucosinolates ; extra-virgin olive oils ; oleuropein ; phenols ; tocopherols ; HPLC-MS ; multivariate statistical data ; 6-gingerol ; 6-shogaol ; commercial formulation ; ginger extract ; green reversed phase high-performance thin-layer chromatography (RP-HPTLC) ; simultaneous analysis ; kaempferol ; Ocimum basilicum ; high performance thin layer chromatography in connection with ultraviolet detection (HPTLC-VIS) ; box-Behnken design ; optimization ; validation ; microalgae ; isolation ; identification ; lipid productivity ; berries ; fruit wines polyphenols identification ; LC–MSn ; whole barley flour ; pearling fractions ; proteins ; β-glucans ; arabinoxylans ; tocols ; phenolic compounds ; antioxidant capacity ; functional food ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 82
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: This book contains seven reviews and four research articles on the various modern approaches to the problem of quark confinement in quantum chromodynamics (QCD). These approaches include microscopic models of the Yang–Mills vacuum, which are based on the condensation of magnetic monopoles and center vortices, as well as the models of the confining quark-antiquark string. Possible applications of these models to the analysis of the novel superinsulating state, which emerges in such condensed-matter systems as Josephson junction arrays, are further discussed in one of the reviews. Two reviews from this collection discuss the approaches towards the analytic construction of effective confining theories, at the classical level and within the center-vortex model of the Yang–Mills vacuum. Other aspects of non-perturbative physics addressed by this collection include a possible connection between the localization of low-lying Dirac eigenmodes with the deconfinement and the chiral QCD phase transitions, as well as the role of topology in baryon-rich matter. Last but not least, a novel model of dark matter, based on ultralight axion particles, whose masses are arising due to distinct SU(2) Yang–Mills scales and the Planck mass, is suggested and developed in one of the contributed articles.
    Schlagwort(e): quantum chromodynamics ; confinement ; center vortex model ; vacuum structure ; cooling ; Lattice Gauge Theories ; Effective String Theories ; localization ; QCD ; lattice gauge theory ; finite temperature ; galaxy rotation curves ; low surface brightness ; dark matter ; dark energy ; ultralight axion particles ; cores ; halos ; mass-density ; profiles ; pure Yang–Mills theory ; monopoles ; topological interactions ; ensembles and effective fields ; topological solitons ; higher order theories ; gauge theory ; effective field theory ; magnetic flux symmetry ; chiral symmetry ; monopole ; lattice QCD ; spontaneous symmetry breaking ; Abelian projection ; magnetic catalysis ; magnetic disorder ; confinement models ; center vortices ; magnetic monopoles ; quark condensate ; topology ; lattice field theory ; dense matter ; phase transitions ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 83
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-05-06
    Beschreibung: The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments, and even within the segment, are dependent on many factors, e.g., the surrounding pH, fluid composition, transporters expression, metabolic enzymes activity, tight junction resistance, different morphology along the GIT, variable intestinal mucosal cell differentiation, changes in drug concentration (in cases of carrier-mediated transport), thickness and types of mucus, and resident microflora. Each of these variables, alone or in combination with others, can fundamentally alter the solubility/dissolution, the intestinal permeability, and the overall absorption of various drugs. This is the underlying mechanistic basis of regional-dependent intestinal drug absorption, which has led to many attempts to deliver drugs to specific regions throughout the GIT, aiming to optimize drug absorption, bioavailability, pharmacokinetics, and/or pharmacodynamics. In the book "Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation" we aim to highlight the current progress and to provide an overview of the latest developments in the field of regional-dependent intestinal drug absorption and delivery, as well as pointing out the unmet needs of the field.
    Schlagwort(e): bioequivalence ; Biopharmaceutics Classification System ; in vitro ; dissolution test ; pravastatin ; oral absorption ; in silico modeling ; GastroPlus ; Phoenix WinNonlin ; pharmacokinetics ; clinical studies ; ibuprofen ; manometry ; gastrointestinal ; mechanistic modeling ; PBPK ; PBBM ; disintegration ; dissolution ; enteric-coated ; ICH ; quality control ; regional intestinal permeability ; permeation enhancers ; absorption-modifying excipients ; oral peptide delivery ; intestinal perfusion ; pharmaceutical development ; controlled release drug product ; biopharmaceutics classification system ; drug solubility ; drug permeability ; location-dependent absorption ; segregated flow intestinal model (SFM) ; traditional model (TM) ; route-dependent intestinal metabolism ; first-pass effect ; drug-drug interactions ; DDI ; in vitro in vivo extrapolations ; IVIVE ; zero-order absorption ; first-order absorption ; combined zero- and first-order absorption ; transit compartment absorption model ; in situ perfusion ; microdevices ; shape ; mucoadhesion ; colon absorption ; nutrient digestion ; nutrient absorption ; gastrointestinal hormone ; postprandial glycaemia ; energy intake ; region of the gut ; obesity ; type 2 diabetes ; Franz–PAMPA ; BCS drugs ; biomimetic membrane ; Franz cell ; passive drug transport ; BCS class IV drugs ; segmental-dependent intestinal permeability ; intestinal absorption ; oral drug delivery ; biopharmaceutics ; physiologically-based pharmacokinetic (PBPK) modeling ; furosemide ; intestinal permeability ; human colon carcinoma cell layer (Caco-2) ; hierarchical support vector regression (HSVR) ; drug absorption ; drug solubility/dissolution ; regional/segmental-dependent permeability and absorption ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
    Sprache: Englisch
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  • 84
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: The notion of smart and sustainable cities offers an integrated and holistic approach to urbanism by aiming to achieve the long-term goals of urban sustainability and resilience. In essence, a smart and sustainable city is an urban locality that functions as a robust system of systems with sustainable practices to generate desired outcomes and futures for all humans and non-humans. This book contributes to improving research and practice in smart and sustainable metropolitan as well as regional cities and urbanism by bringing together literature reviews and scholarly perspective pieces, forming an open access knowledge warehouse. It contains contributions that offer insights into research and practice in smart and sustainable metropolitan and regional cities by producing in-depth conceptual debates and perspectives, insights from the literature and best practice, and thoroughly identified research themes and development trends. This book serves as a repository of relevant information, material, and knowledge to support research, policymaking, practice, and the transferability of experiences to address challenges in establishing smart and sustainable metropolitan as well as regional cities and urbanism in the era of climate change, biodiversity collapse, natural disasters, pandemics, and socioeconomic inequalities.
    Schlagwort(e): regional towns ; regional cities ; regional Australia ; regional lifestyle location ; regional innovation system ; regional turnaround ; post-pandemic urban growth ; COVID-19 impact ; regional planning ; sustainable urban development ; smart cities ; blockchain ; building information management (BIM) ; city information management (CIM) ; sustainable building ; life cycle ; VOSviewer ; commuting ; employment ; housing price ; GDP ; income ; big data ; prediction ; urbanization ; sustainability ; corporate social responsibility ; ready-made garments ; framework for strategic sustainable development ; Bangladesh ; PCB shield ; HX711 ; amplifier chip ; Sim900A ; e-commerce ; virtual store ; firmware ; embedded system ; virtual reality and haptic sensing ; urban sustainability ; sustainable behavior ; sustainability understanding ; awareness ; perception ; attitude ; pro-environmental behavior ; influencing factors ; Turkey ; Istanbul ; sustainable city ; sustainable development ; environmental performance ; online platform ; municipalities ; artificial intelligence (AI) ; green AI ; sustainable AI ; responsible AI ; ethical AI ; explainable AI ; AI regulation ; green sensing ; sustainable development goals ; waste sorting ; supply chain redesigning ; function allocation ; path planning ; incinerable waste ; smart city ; smart city industry ; industrial ecosystem ; input–output analysis ; structural path analysis ; knowledge-based development ; knowledge-based urban development ; smart and sustainable city ; local development ; urban development ; knowledge cities world summit ; international events ; Bento Gonçalves ; Brazil ; technology ; governance ; knowledge workers ; knowledge precincts ; open data ; Gold Coast ; digital engineering ; information requirements ; infrastructure asset management ; technology integration matrix ; master-planned estate ; community ; community identity ; social connectedness ; social infrastructure: physical infrastructure ; housing developments ; longitudinal study ; social capital ; neighbourhoods ; sustainable social development ; ecological study ; ordinal logistic regression ; northern Sweden ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVG Environmental economics
    Sprache: Englisch
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  • 85
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Natural Antioxidants: Innovative Extraction and Application in Foods compiles comprehensive information and recent findings on the extraction of antioxidants from different natural resources and investigates their application in food. The book focuses on different sources of natural antioxidants such as the Hypochaeris and Hyoseris species, pomegranate seed oil, thyme, hemp, coriander, olive mill wastewaters, the edible mushroom Hericium erinaceus, Brewer’s spent grain, broccoli byproducts, cardoon, and Norway spruce bark. Moreover, the effect of different treatments such as blanching, microwave exposure, roasting, and enzymatic browning on the phytochemical content and bioactivity of the extracts is also addressed. Readers will find valuable insights into the impact of extraction methodologies on the bioactivity of the extracts, along with an understanding of the vast potential of natural extracts for the quality of food products. Readership Food and nutrition researchers, health professionals, nutritionists, and food science and chemistry students
    Schlagwort(e): supercritical fluid extraction ; pressurized liquid extraction ; ultrasound-assisted extraction ; trans-resveratrol ; Norway spruce bark ; shelf life ; byproducts ; fresh pasta ; vegetable extracts ; antimicrobial activity ; wood waste ; phenolic profile ; planar chromatography ; DPPH-HPTLC assay ; Cynara cardunculus L. ; cardoon leaves ; by-products ; antioxidant activity ; ferulic acid ; brewer’s spent grain ; alkaline hydrolysis ; adsorption ; synthetic resin ; macroporous resin XAD-7HP ; olive mill wastewaters ; oxidative stability ; polyphenols ; sunflower oil ; enzymatic browning ; antioxidant compounds ; Hericium erinaceus ; mushroom metabolites ; polyphenol oxidase ; tyrosinase ; laccase ; natural inhibitor ; selenomethionine ; green coffee ; acrylamide ; Arabica ; Robusta ; Maillard reaction ; selenium uptake ; pretreatment ; ultrasound assisted extraction—UAE ; rapid solid-liquid dynamic extraction—RSLDE ; gas chromatography-mass spectrometry—GC-MS ; antioxidants ; C. sativa ; T. vulgaris ; C. sativum ; pomegranate seeds ; oil ; microwave pretreatment ; total phenolic content ; antioxidant capacity ; Hyoseris radiata ; Hyoseris taurina ; Hypochaeris laevigata ; Hypochaeris radicata ; phytochemicals ; obesity ; diabetes type 2 ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 86
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-02-24
    Beschreibung: Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests.The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first “site-agnostic” drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic “signatures” that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.
    Schlagwort(e): patient-derived tumor xenograft (PDX) ; anti-cancer drug development ; immunodeficient mice ; precision medicine ; molecular profiling ; immunohistochemistry ; next-generation sequencing ; targeted therapy ; molecular oncology ; biomarkers ; molecular imaging ; non-small cell lung cancer ; proliferation ; cancer stem cells ; circulating tumour cells ; personalised treatment ; renal cell carcinoma ; clear cell ; VEGF ; immunotherapy ; PD-L1 ; immune checkpoint inhibitors ; immune checkpoint blockade ; tyrosine-kinase inhibitors ; integrin-linked kinase (ILK) ; ovarian cancer ; sgRNA ; gene expression ; microarray ; xenograft ; MTB ; cancer ; oncology practice ; community setting ; CGP ; pancreatic cancer ; FOLFIRINOX ; chemotherapy ; gender ; cholangiocarcinoma ; biliary tract cancer ; prognosis ; neutrophils ; BRCA1 ; BRCA2 ; PALB2 ; homologous recombination repair ; colorectal cancer ; heme oxygenase-1 ; endothelin-1 ; endothelin con-verting enzyme-1 ; bosentan ; precision oncology ; tumor-agnostic indications ; solid tumors ; tumor markers ; FDA-approved therapeutics ; n/a ; bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 87
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: The Special Issue “Game Theory” of the journal Mathematics provides a collection of papers that represent modern trends in mathematical game theory and its applications. The works address the problem of constructing and implementation of solution concepts based on classical optimality principles in different classes of games. In the case of non-cooperative behavior of players, the Nash equilibrium as a basic optimality principle is considered in both static and dynamic game settings. In the case of cooperative behavior of players, the situation is more complicated. As is seen from presented papers, the direct use of cooperative optimality principles in dynamic and differential games may bring time or subgame inconsistency of a solution which makes the cooperative schemes unsustainable. The notion of time or subgame consistency is crucial to the success of cooperation in a dynamic framework. In the works devoted to dynamic or differential games, this problem is analyzed and the special regularization procedures proposed to achieve time or subgame consistency of cooperative solutions. Among others, special attention in the presented book is paid to the construction of characteristic functions which determine the power of coalitions in games. The book contains many multi-disciplinary works applied to economic and environmental applications in a coherent manner.
    Schlagwort(e): pursuit ; control functions ; integral constraints ; strategies ; value of the game ; decision-making ; game theory ; project management ; differential games ; cooperative differential games ; Time Consistency ; IDP-core ; IDP dominance ; two-sided platform market ; pricing ; Hotelling’s duopoly on the plane ; Nash equilibrium ; optimal location of platforms ; prescribed duration ; characteristic function ; environmental resource management ; pollution control ; discrete-time games ; cooperation ; the core ; linear transformation ; time consistency ; multistage game ; chance moves ; subgame perfect equilibria ; cooperative trajectory ; imputation distribution procedure ; random time horizon ; time until failure ; discounted equilibrium ; weibull distribution ; chen distribution ; equivalence principle ; cooperative game ; satisfaction criteria ; proportional value ; axiomatization ; cooperative stochastic game ; strong subgame consistency ; core ; dynamic games ; multicriteria games ; Nash bargaining solution ; dynamic stability ; rational behavior conditions ; Shapley-Solidarity value ; coalition structure ; potential ; bidding mechanism ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science
    Sprache: Englisch
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  • 88
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Today, new technologies bring with them an everchanging panorama, forcing us to constantly update our knowledge. For this reason, quality education is necessary in all areas of knowledge and at all educational levels. The quality of our educational systems and the questions raised by reviewing whether our educational institutions offer quality education or not are some of the main reasons why quality education is a topic that, in recent years, has captured the interest of governments, researchers and lecturers, among others. This issue brings together different socioeducational actors with their concerns for and commitments to higher education, in order to achieve the aim of providing people with the competencies necessary to adapt to a changing and competitive world, in which the individual needs to engage in lifelong learning and where education must align with sustainable development goals, such as democracy, justice and equality. All of this provides us with a scenario for reflecting on and researching fundamental questions, such as how to prevent school absenteeism, how to deal with students leaving school early, how to prevent or alleviate the phenomenon of dropping out in higher education, etc. In other words, can we assume that student failure is partly due to the failure of our educational systems? Are we educating self-regulated, critical, learning-motivated and competent students? These and other questions lead us to search for measures with which we can improve the quality of our educational systems by proposing strategies and developing tools to enhance the lecturing–learning processes in our classrooms.
    Schlagwort(e): higher education ; inclusive education ; disability ; technological platforms ; faculty members ; international students ; service quality evaluation ; perceived satisfaction ; sustainable higher education system ; China ; active learning ; career adaptability ; Hong Kong ; human resources management ; university students ; university teaching ; mobile-assisted language learning ; foreign language learning ; productive-receptive skills ; technology acceptance model ; WhatsApp ; Line App ; VET ; European ; validation principles ; Spain ; virtual meeting platform ; technology readiness ; social presence ; course satisfaction ; sustained use intention ; serial mediation ; science scenario ; collaborative problem solving ; behavioral transition patterns ; lag sequential analysis ; disadvantaged students ; higher education SPROUT project ; learning effects ; qualitative changes ; distance learning ; university authorities ; lecturers ; students ; cross-cultural pragmatic competence ; social context ; communicative dynamics in classroom situations ; EFL context ; online instruction ; students’ perceptions ; education quality ; online learning ; socioemotional competence ; models ; emotional intelligence ; social intelligence ; TAM Model ; learning analytics ; academic performance ; COVID-19 ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 89
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    Unbekannt
    University of Calgary Press
    Publikationsdatum: 2022-07-19
    Beschreibung: The University of Calgary’s innovative and collaborative approach to health care education is celebrated in an interdisciplinary collection. Bedside and Community is the inside story of fifty years of health care and health research at the University of Calgary. Drawing on the first-person accounts of researchers, administrators, faculty, and students along with archival research, and faculty histories, this collection celebrates the many significant contributions the University of Calgary has made to the health of Albertans. With contributions from the Cumming School of Medicine, the Faculty of Nursing, Faculty of Kinesiology, Faculty of Veterinary Medicine, Faculty of Environmental Design, Department of Psychology, and Indigenous Health Initiatives Bedside and Community is a truly collaborative history. Addressing the links between departments, the relationship between the university and the community, and evolving research and teaching methods, this book places the University of Calgary within a wider national context and shows how it has addressed the unique health needs of Southern Alberta. With a pioneering focus on primary care and commitment to interdisciplinary connections, the University of Calgary has made strides in health research, health education, and community outreach. Bedside and Community tells the story of a tradition of excellence that will light the way to future outreach and discovery.
    Schlagwort(e): Medicine ; Nursing ; Education ; Health ; Veterinary ; Medical administration ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBD Medical profession::MBDC Medical ethics & professional conduct
    Sprache: Englisch
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  • 90
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Many recent events, including the COVID-19 pandemic and climate change, have proven the necessity of a transformation of the current economic system based on a linear schema of: “take”, “make”, “use”, and “dispose”. This radical change should involve all of the actors involved in the economic system: institutions, industries, consumers, and scientific research. Only cooperation among these stakeholders can ensure an effective shift toward a circular model. However, which kinds of actions can be performed to implement an effective circular economy? The present Special Issue collects nine papers that prove the possibility of implementing the circular economy from different points of view. The authors analyze all of the spheres of sustainability (environmental, economic, and social) in a variety of contexts, evaluating the effect of the circular choices. The nine papers include several key product value chains, in agreement with the most recent European Circular Economy Action Plan (e.g., electronics and ICT, batteries, plastics, construction and buildings, and food). The present paper collection proves that the circular economy is not only a simple business model, but rather, it involves the integration of many strategies for the protection of the natural ecosystem and the maintenance of worldwide economic stability. The holistic approach is essential for a successful business model, and innovation has an indispensable role in the transition. In this context, the present Special Issue aims to be a multidisciplinary collection of innovations useful for all of the stakeholders involved in the circular economy.
    Schlagwort(e): printed circuit boards ; biotechnologies ; circular economy ; Aspergillus niger ; copper ; zinc ; food waste ; life cycle assessment ; secondary mining resources ; electrodialytic process ; upscale ; tungsten ; arsenic ; hydrogen ; agriculture residue ; environmental sustainability ; bio-based product ; innovation capability and resilience ; business dynamics ; ecoinnovation index ; R&D personnel by sector ; inclusiveness ; stakeholders ; capacity building ; entrepreneurship ; cooperative business models ; collaborative networks ; lithium-ion batteries (LIBs) ; energy storage ; Extended Producer Responsibility (EPR) ; European Union (EU) legislation ; critical raw materials (CRM) ; organizational sustainability ; knowledge management ; total quality management ; sustainable development ; linear economy ; circular design ; circularity ; vernacular architecture ; Egypt ; competitiveness ; investments and patents governance ; innovation and policy for sustainability ; societal transformation ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 91
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Enter For a long time, natural medicine has been used as a therapeutic therapy based on generations of indigenous practices. Today the rise in natural remedies has been largely driven by public demand and billions of dollars are spent annually on herbal medicines. It is therefore important to document the effectiveness of natural medicine, its potential side effects, and potential interactions.
    Schlagwort(e): Piper sylvaticum ; anxiolytic ; antioxidant ; molecular docking ; phytochemistry ; Stevia serrata ; essential oil ; inflammation ; antinociception ; pain ; Alzheimer’s disease ; cognitive function ; streptozotocin ; Orthosiphon stamineus ; oxidative stress ; terpenoids ; invasomes ; thymol ; menthol ; camphor ; cineol ; S. aureus ; E. coli ; bactericidal ; Aristolochia trilobata ; sulcatyl acetate ; antinociceptive effect ; anti-inflammatory activity ; Rhamnus triquetra ; NiONPs ; cytotoxicity ; biocompatibility ; antimicrobial ; enzyme inhibition ; Coriolus versicolor ; Trametes ; cancer ; polysaccharides ; PSP ; PSK ; immunostimulation ; adjuvant therapy ; isoquercitrin ; cardiovascular anaphylaxis ; rats ; guinea pigs ; histamine ; β-Caryophyllene ; CB2 receptors ; oral mucositis ; periodontitis ; ergosterol ; cyclin D1 ; androgen receptor ; 5α-reductase ; bladder cancer ; hemocyanin ; snail Rapana venosa ; snail Helix lucorum ; snail Helix aspersa ; antitumor activity ; colorectal adenocarcinoma ; apoptosis ; resveratrol ; transforming growth factor-beta (TGF-β) ; chronic diseases ; fibrosis ; diabetes ; therapy ; natural antimicrobial ; antimicrobial resistance ; polyphenols ; future medicine ; natural origin ; antibacterial compound ; phytochemicals ; dental diseases ; luteolin ; flavonoids ; lipopolysaccharide ; anti-inflammatory ; autophagy ; phytochemical ; natural compound ; treatment ; Centella asiatica L. ; Curcuma longa L. ; Bdnf ; mTOR ; protein synthesis ; neuroplasticity ; botanicals ; Withaferin A ; anticancer ; chaperone ; cisplatin ; coffee ; kahweol ; acute kidney injury ; necroptosis ; plumericin ; inflammatory bowel disease ; intestinal epithelial cells ; experimental colitis ; intestinal barrier ; cellular stress response ; neurodegenerative disorders ; ER stress proteotoxicity ; neuroinflammation ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 92
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-28
    Beschreibung: This book proposes a list of contributions in the field of control of power electronics converters for different topologies: DC-DC, DC-AC and AC-DC. It particularly focuses on the use of different advanced control techniques with the aim of improving the performances, flexibility and efficiency in the context of several operation conditions. Sliding mode control, fuzzy logic based control, dead time compensation and optimal linear control are among the techniques developed in the special issue. Simulation and experimental results are provided by the authors to validate the proposed control strategies.
    Schlagwort(e): Power ; electronic ; converters ; DC-DC ; DC-AC ; AC-DC ; Nonlinear ; control ; Microgrids ; Intelligent ; Hybrid ; Robust ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Sprache: Englisch
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  • 93
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-05-06
    Beschreibung: The first national conference with international participation, “Fundamental aspects of atherosclerosis: scientific research for improving the technologies of personalized medicine”, was held in Novosibirsk on 15 October, 2021. The purpose of this conference was to disseminate the latest basic and clinical findings in the fields of etiology, clinical characteristics, and modern diagnostics and treatments of atherosclerosis among various relevant specialists. The conference was intended for practicing cardiologists, primary care physicians, medical geneticists, and physician–scientists. The conference included plenary sessions, specialty sessions, satellite symposia, an open competition for young scientists.
    Schlagwort(e): metalloproteinases ; calcification ; atherosclerosis ; multiplex assay ; coronary heart disease ; aspirin ; resistance ; non-sensitivity ; antiplatelet ; light transmission aggregometry ; Plateletworks® ; familial hypercholesterolemia ; targeted sequencing technologies ; multiplex ligation-dependent probe amplification ; LDLR ; APOB ; ABCG5 ; APOC3 ; LPL ; SREBF1 ; rare variants ; coronary atherosclerosis ; ischemic heart disease ; saturated fatty acids ; monounsaturated fatty acids ; polyunsaturated fatty acids ; oxidative stress ; superoxide dismutase ; catalase ; glutathione peroxidase ; cumulative LDL-C level ; prognosis ; DNA methylation ; epigenetic age ; myocardial infarction ; acute coronary syndrome ; population ; nested case-control ; HAPIEE project ; HAPIEE study ; atrial fibrillation ; arterial hypertension ; obesity ; diabetes mellitus ; aging ; determinants ; prevalence ; Russian population cohort ; Cox regression analysis ; adiponectin ; leptin ; interleukin-6 ; epicardial adipose tissue ; perivascular adipose tissue ; circulating biochemical markers ; coronary atherosclerosis presence and severity ; integrated biomarker (i-BIO) ; validation ; visual markers ; lipoprotein(a) ; immune cells blood count ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
    Sprache: Englisch
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  • 94
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Children today face significant challenges in response to living in a globalised world and the impact of environmental threats to the planet. As such, there is an increasing need for schools to have a global perspective and to cultivate a critical sense of environmental and social responsibility in students. Environmental and Sustainability Education (ESE) in schools is frequently promoted as a route to achieving this, as it has the potential to empower learners to develop the necessary knowledge, understanding, skills, or competences to respond to the complex socio-environmental issues. However, there remains a general lack of pedagogical consensus as to how to teach either about or for ESE within school contexts.To develop effective ESE pedagogies, some educators look to transformative learning theory to encourage learners to move beyond the simple acquisition of knowledge to a change in worldview which not only affects their deeper level of understanding but, importantly for ESE, builds their capacity to think critically and plays an active role in providing a sustainable transformation of society. This book explores the pedagogy and practice of ESE, particularly focus on transformative pedagogies. Exploring themes including the attitudes of the teachers who are implementing transformative pedagogies, the tensions and emotional loads that teachers experience when seeking to develop their professional identity in the context of ESE, and how learning through ESE-informed practice involves and is intimately connected with emotions, this book will be of significant value for researchers and practitioners globally looking to develop transformative ESE practice.
    Schlagwort(e): education ; didactics ; teaching ; learning ; pragmatism ; sustainability commitment ; sustainability ; sustainable development ; cultural diversity ; teacher quality ; transculturalism ; educational transformation ; Environmental and Sustainability Education ; geography teacher ; teacher identity ; Environmental and Sustainability Education (ESE) ; secondary schools ; Initial Teacher Education (ITE) ; selective traditions ; teaching traditions ; teaching habits ; environmental and sustainability education ; functions of teaching ; functions of education ; ESD teaching approaches ; transformative sustainability learning ; collaborative reflection ; sport and the environment ; sport ecology ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 95
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: This book offers a specialized study focusing on the phenomenon of the female mystic and the divine feminine in the global Sufi experience. Drawing on classical and modern periods, it presents a considered approach to the topic from the disciplines of literature, history, religion, philosophy, language and linguistics, and anthropology. As each author offers their expertise in their respective fields, each article, therefore, whilst a standalone piece, contributes collectively to the multidisciplinary understanding of the female and the feminine in Sufi experience. The book addresses the topic from different points of view, showing the authors’ interest in subjectivity, literary and artistic productivity, as well as notable figures of importance, but narrows the purview of its examination to case studies, historical periods, and philosophical concerns of relevance. Focused areas of inquiry include the economic power of Sufi women in history; the hierophanic dialectics of mystical Islamic poetry with regard to “the feminine” experience in Yunus Emre; the ontology of the sacred feminine and female mystic in classical Sufi poiesis; the mystical autochthonous presence in local Sufi praxis of Indonesia; reconfigurations of gendered understanding in Argentinian Sufism; and symbolism and spiritual psychology in Sufi cosmology. This book is an interdisciplinary publication that brings together an international host of scholars from around the world, including University of Amsterdam, University of St Gallen, University of Haifa, Western Sydney University, Monash University, and Australian National University.
    Schlagwort(e): sacred feminine ; divine feminine in Sufism ; Sufi orders ; female saints ; female leadership in Sufism ; Dewi Anjani ; Nahdlatul Wathan ; Lombok ; Indonesia ; indigenous feminine ; Sufism ; female mystic ; divine feminine ; phenomenology ; history ; mysticism ; Aredvi Sura Anahita ; Mount Qaf ; Divine Feminine ; Xvarnah ; Khezr ; mystical experience ; Yunus Emre ; the Feminine ; hierophanic dialectics ; deconstruction ; literary analysis ; phenomenology of Sufi ; arfāq al-niswān (women’s donations) ; sisters ; mothers ; ḥaqq al-wālida (mother’s right) ; poverty ; charity ; khidma (service) ; Sufism in Latin America ; Islam in Latin America ; gender and Sufism ; Naqshbandiyya Haqqaniyya ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 96
    facet.materialart.
    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: This book covers different topics in the framework of remote sensing of the oceans. Latest research advancements and brand-new studies are presented that address the exploitation of remote sensing instruments and simulation tools to improve the understanding of ocean processes and enable cutting-edge applications with the aim of preserving the ocean environment and supporting the blue economy. Hence, this book provides a reference framework for state-of-the-art remote sensing methods that deal with the generation of added-value products and the geophysical information retrieval in related fields, including: Oil spill detection and discrimination; Analysis of tropical cyclones and sea echoes; Shoreline and aquaculture area extraction; Monitoring coastal marine litter and moving vessels; Processing of SAR, HF radar and UAV measurements.
    Schlagwort(e): ocean modeling ; counter-flow ; vertical migration ; Kuroshio intrusion ; marine economy ; storm surge ; tropical cyclone size (TC size) ; ideal test ; marine-economic effects ; Northern East China Sea (NECS) ; surface currents ; HF radar ; eddy detection algorithms ; general compact polarimetry ; hybrid dual-polarization ; oil spill discrimination ; target decomposition ; ocean environment ; oil spill ; Synthetic Aperture Radar ; polarimetric decomposition ; superpixel ; convolutional neural networks ; unmanned-aerial-vehicles ; UAVs ; anthropogenic-marine-debris ; AMD ; beached-marine-litter ; BML ; marine-protected-areas ; MPA ; ortho-photo ; marine-pollution ; accumulation-rate ; synthetic aperture radar (SAR) ; moving vessel ; multicomponent polynomial phase signal(mc-PPS) ; adaptive joint time-frequency (AJTF) decomposition ; co-evolutionary particle swarm optimization ; airborne HF/VHF radar ; sea echo ; mathematical model ; radar cross section ; marine raft aquaculture ; Sentinel-1 ; nonsubsampled contourlet transform ; semantic segmentation ; fully convolutional network ; SAR images ; shoreline extraction ; geometric active contour model ; SAR ; sentinel-1 ; low-backscattering areas ; azimuth autocorrelation function ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 97
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    Firenze University Press
    Publikationsdatum: 2022-06-02
    Beschreibung: The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus.
    Schlagwort(e): bic Book Industry Communication::M Medicine
    Sprache: Englisch
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  • 98
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: Chirality, or handedness, is a fundamental physical characteristic, which spans the length scales ranging from elementary particles to the chiral asymmetry of spiral galaxies. The way in which chirality in chemistry, or molecular handedness, may have emerged in a primitive terrestrial environment, and how it can be triggered, amplified, and transferred, are deeply challenging problems rooted in both fundamental scientific interests and the technological potentials for science and society. Chirality constitutes a unifying feature of the living world and is a prime driving force for molecular selection and genetic evolution in biology. In this book, we offer a selection of five distinct approaches to this problem by leading experts in the field. The selected topics range from protein chirality and its relevance to protein ageing, protein aggregation and neurodegeneration, entropy production associated with chiral symmetry breaking in closed systems, chiral oscillations in polymerization models involving higher-order oligomers, the mirror symmetry breaking in liquids and its implications for the development of homochirality in abiogenesis, the role of chirality in the chemical sciences, and some philosophical implications of chirality.
    Schlagwort(e): biochirality ; post-translational modifications ; protein folding ; protein aggregation ; spontaneous chemical reactions ; neurodegeneration ; non-equilibrium phase transitions ; chiral symmetry breaking ; entropy production ; closed systems ; nonequilibrium ; dissipative structures ; mirror symmetry breaking ; biological chirality ; liquid crystals ; proto-RNA ; networks ; compartmentalization ; chiral liquids ; cubic phases ; prebiotic chemistry ; chirality amplification ; helical self-assembly ; chiral oscillations ; spontaneous mirror symmetry breaking ; origin of homochirality ; absolute asymmetric synthesis ; biological homochirality ; chemical abiotic evolution ; chirality ; origin of life ; dissipative reaction systems ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 99
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2024-03-27
    Beschreibung: BioPolymers could be either natural polymers – polymer naturally occurring in Nature, such as cellulose or starch…, or biobased polymers that are artificially synthesized from natural resources. Since the late 1990s, the polymer industry has faced two serious problems: global warming and anticipation of limitation to the access to fossil resources. One solution consists in the use of sustainable resources instead of fossil-based resources. Hence, biomass feedstocks are a promising resource and biopolymers are one of the most dynamic polymer area. Additionally, biodegradability is a special functionality conferred to a material, bio-based or not. Very recently, facing the awareness of the volumes of plastic wastes, biodegradable polymers are gaining increasing attention from the market and industrial community. This special issue of Molecules deals with the current scientific and industrial challenges of Natural and Biobased Polymers, through the access of new biobased monomers, improved thermo-mechanical properties, and by substitution of harmful substances. This themed issue can be considered as collection of highlights within the field of Natural Polymers and Biobased Polymers which clearly demonstrate the increased interest in this field. We hope that this will inspire researchers to further develop this area and thus contribute to futures more sustainable society.”
    Schlagwort(e): imine ; epoxide ; amine ; thermoset ; bio-based ; biobased epoxy ; cardanol ; cationic photocuring ; microfibrillated cellulose ; biobased composites ; sustainable materials ; biomass ; green chemistry ; mechanims ; humins ; epoxy resins ; thermosets ; kinetics ; ring-opening ; biobased ; polyurethane foam ; catalyst ; polycarbonates ; furan-maleimide ; Diels-Alder ; fatty acids ; melt extrusion ; 3D printing ; cellulose nanofibrils ; biocomposite filaments ; physical property ; drained and undrained peatlands ; peats ; humic acids ; thermal ; paramagnetic and optical properties ; acetylated starch ; etherified starch ; chemical composition ; macromolecular characteristics ; surface characterization ; lignin ; fractionation ; biobased polymers ; solvent extraction ; membrane-assisted ultrafiltration ; plant oil-based monomers ; mixed micelles ; methyl-β-cyclodextrin inclusion complex ; emulsion polymerization ; nanocellulose ; polymer ; coating ; textile ; adhesion ; biobased monomer ; photoinduced-polymerization ; eugenol-derived methacrylate ; bacterial cellulose ; alginate ; gelatin ; curcumin ; biomaterials ; chitosan ; silane coupling agent ; microfiber ; crosslinking ; mechanical strength ; block copolymers ; renewable resources ; RAFT ; alkyl lactate ; PSA ; terpenoid ; exo-methylene ; conjugated diene ; renewable monomer ; biobased polymer ; radical polymerization ; copolymerization ; living radical polymerization ; RAFT polymerization ; heat-resistant polymer ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Sprache: Englisch
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  • 100
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    Unbekannt
    MDPI - Multidisciplinary Digital Publishing Institute
    Publikationsdatum: 2022-05-06
    Beschreibung: Dear Readers, Oncolytic Viruses (OV) are self-propagating agents that can selectively induce the lysis of cancer cells while sparing normal tissues. OV-mediated cancer cell death is often immunogenic and triggers robust anticancer immune responses and immunoconversion of tumor microenvironments. This makes oncolytic virotherapy a promising new form of immunotherapy and OVs ideal candidates for combination therapy with other anticancer agents, including other immunotherapeutics. There are more than 40 OVs from nine different families in clinical development and many more at the preclinical stage. Each OV has its own unique characteristics, its pros and cons. Although herpes simplex virus is currently the lead clinical agent, a real champion among the OVs has not yet emerged, justifying the continuous development and optimization of these agents. This book, “Oncolytic Virus Immunotherapy”, summarizes the state-of-the-art and gives a comprehensive overview of the OV arena with a particular focus on new trends, directions, challenges, and opportunities.
    Schlagwort(e): oncolytic viruses ; melanoma ; immunotherapy ; checkpoint inhibitors ; combinatory therapy ; reovirus ; oncolytic virus ; adenovirus ; oncolytic ; virotherapy ; targeting ; immunogenic cell death ; αvβ6 integrin ; oncolytic adenovirus ; cancer immunotherapy ; multi-stage ; immunostimulatory ; arming ; HSV-1 ; clinical trials ; newcastle disease virus ; NDV ; cancer ; immune checkpoint inhibitor ; PD-1 ; PD-L1 ; CTLA-4 ; type I interferon ; herpes simplex virus ; retargeted virus ; tropism retargeting ; tumor ; checkpoint inhibitor ; vaccination ; antigen-agnostic vaccination ; HER2 ; parvovirus ; tumor microenvironment ; combination therapy ; glioblastoma ; pancreatic cancer ; colorectal cancer ; measles virus ; vector engineering ; immune checkpoint blockade ; antitumor immune response ; delivery ; genetic modification ; biomarkers ; personalized oncolyticvirotherapy ; class I HLA ; immunosurveillance ; immunoediting ; oncogenic signaling ; RAS ; DNA methyltransferase inhibitor (DNMTi) ; viral mimicry ; epigenetic silencing ; adoptive T cell therapy ; CAR T cell ; pancreatic ductal adenocarcinoma ; vesicular stomatitis virus ; small molecule ; cancer immune therapy ; cancer therapy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
    Sprache: Englisch
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