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  • Articles  (148)
  • Chemistry  (148)
  • Engineering
  • nitrogen
  • 1965-1969  (148)
  • Medicine  (148)
  • Electrical Engineering, Measurement and Control Technology
  • Energy, Environment Protection, Nuclear Power Engineering
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  • Articles  (148)
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  • 1
    Electronic Resource
    Electronic Resource
    Editorial (1967)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 1 (1967), S. 1-2 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820010102
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  • 2
    Electronic Resource
    Electronic Resource
    Masthead (1967)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 1 (1967) 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820010101
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  • 3
    Electronic Resource
    Electronic Resource
    The in vivo metabolic degradation of poly (methyl cyanoacrylate) via thiocyanate (1967)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 1 (1967), S. 11-16 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Methyl α-cyanoacrylate, when implanted subcutaneously in rats and dogs, has been shown to lead to an increase in thiocyanate output in the urine, presumably through the formation of cyanide anions which are subsequently converted to thiocyanate. It is postulated that this reaction may be one of the reactions contributing to tissue necrosis when methyl α-cyanoacrylate is used as a tissue adhesive.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820010104
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  • 4
    Electronic Resource
    Electronic Resource
    Tissue adhesives and hemostasis-inducing compounds: The alkyl cyanoacrylates (1967)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 1 (1967), S. 3-9 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: In an effort to obtain tissue adhesive monomers which would wet and spread on tissue substrates and be rapidly biodegradable, the branched esters of alkyl α-cyanoacrylates, as well as a 95-5 wt.-% mixture of n-heptyl and methyl α-cyanoacrylate, were studied. The data indicate that alkyl α-cyanoacrylates having branched alkoxy groups appear to be promising in this regard.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820010103
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  • 5
    Electronic Resource
    Electronic Resource
    Electrochemical behavior of metals as stimulus electrodes (1967)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 1 (1967), S. 27-31 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A theory for the behavior of anodes as stimulus electrodes, particularly as pacemaker electrodes, is presented. Expressions are obtained for the minimum duration and energy of the stimulus. These expressions are applied to that for the dissolution of the anode and transport of the resulting ions in the tissue in order to obtain an estimate of the extent of penetration. Comparison with experimental data indicates good agreement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820010106
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  • 6
    Electronic Resource
    Electronic Resource
    New synthetic membranes for dialysis. IV. A copolyether-urethane membrane systemThis investigation was supported by the John A. Hartford Foundation, Inc. and the National Institute of Arthritis and Metabolic Diseases under Contract No. PH-43-66-493. (1967)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 1 (1967), S. 17-26 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: New dialysis membranes, prepared from linear block copolymers, have shown unique separation properties which appear to be based on definite solute-membrane interaction. The synthesis and characterization of block copolyetherurethanes based on poly (oxyethylene glycol) is described.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820010105
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  • 7
    Electronic Resource
    Electronic Resource
    Problems of materials in mechanical heart systemsSupported by U.S. Public Health Service Grant HE-06510 and Contract PH-43-66-7. (1967)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 1 (1967), S. 33-54 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Currently available materials for mechanical heart systems are surveyed, particularly with respect to long-term implantation, from the viewpoints of availability and workability, mechanical and biological durability, and compatibility with blood and tissue. Some materials have one or more desirable physical properties, but none offers perfect blood and tissue compatibility. Medical grade Silastic, considered best for blood handling parts, has produced promising results in auxiliary ventricle patency experiments. The insufficient tensile strength of Silastic should be increased, and it may be possible to accomplish this while maintaining the present resilience, elongation, and inertness. No long-term data on thrombus formation are available, but clot-retarding quality is essential and may perhaps be obtained by incorporating heparin. Developments in polymer chemistry may also lead to other surfaces with the requisite mechanical properties with blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820010107
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  • 8
    Electronic Resource
    Electronic Resource
    Comparative studies of cyanoacrylate derivatives in vivoThis paper was read by Dr. Ota at the Japanese Society for Artificial Organs and Tissues in July 1964. (1967)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 1 (1967), S. 55-65 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Seven surgical adhesives were prepared; n-butyl, 2-ethylhexyl, and isopropyl cyanoacrylate monomers and several combinations of ethyl cyanoacrylate and a plasticizer (either di-2-ethylhexyl phthalate or tricresyl phosphate). These were implanted as a thin film over the entire circumference of the adventitia of 48 canine carotid arteries. Vicissitude of cyanoacrylate polymers in vivo and tissue reaction to the polymers were traced for 6 months and investigated histologically. All adhesives tested in this study were insoluble in vivo and more resistant to biodegradation than methyl cyanoacrylate polymer. Tissue reaction against n-butyl, 2-ethylhexyl, or isopropyl cyanoacrylate was essentially the same as against ethyl cyanoacrylate in quality and was not less in degree than ethyl cyanoacrylate in spite of having longer side chains than ethyl radical.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820010108
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  • 9
    Electronic Resource
    Electronic Resource
    Metallic and plastic prosthetic devices as vascular wall substitutes: Biophysical criteria and methods for evaluationSupported in part by grants No. HE 03879, 07821, 07371, and 10795 from the National Heart Institute, National Institutes of Health, United States Public Service, Bethesda, Maryland. (1967)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 1 (1967), S. 83-101 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Evidence is presented for the view that intravascular thrombosis proceeds via an electrochemical mechanism. It is strongly substantiated by some recent work on electrical wire thrombosis. These experiments show that thrombosis occurs on noble metal electrodes at potentials more positive than 0.3 v (NHE) but tends not to occur on electrodes more negative than this interfacial potential. Further, the same factors which prevent intravascular thrombosis are shown to prevent thrombosis on electrodes maintained at all potentials up to + 1.0v. Thus occurrence or prevention of thrombosis appears related to electrical and electrochemical properties of both blood and blood vessel wall. Methods for the determination of these properties are described and experimental results briefly presented. The studies have proved useful in establishing criteria for the selection of metal and plastic vascular substitutes. A combination of several electrochemical and biophysical criteria have been discovered which aid in the selection of nonthrombogenic vascular substitutes. Unfortunately not all metals which satisfy anti-thrombotic electrochemical criteria are suitable. Many, including magnesium, have cellular and proteolytic destructive characteristics. Certain metals and electrically treated Teflon tubes do not suffer from this defect and have proven useful in preliminary testing.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820010110
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  • 10
    Electronic Resource
    Electronic Resource
    Improved hemodialysis membranes for the artificial kidneyThis research was supported by the National Institutes of Health, initially by the National Heart Institute under Contract No. PH 43-64-496, and currently by the National Institute of Arthritis and Metabolic Diseases under Contract No. PH 43-66-545. (1967)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 1 (1967), S. 67-81 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A major part of current effort in improving artificial hemodialysis techniques concerns the development of improved membrane structures. Although blood compatibility of membranes is a part of the Battelle program, this discussion is confined to membrane composition, structure, and transport. On the basis of a need for improved hemodialysis techniques, membranes for use in the artificial kidney were prepared and evaluated for urea, creatinine, and uric acid permeability. Water-soluble polymers were crosslinked to form insoluble, but swellable, membranes. Faster metabolic waste transfer than with the conventional cellulosic membranes was obtained with diisocyanate-crosslinked poly (vinyl pyrrolidone) and poly (vinyl pyrrolidone)-dextran membranes and with membranes obtained by crosslinking poly (vinyl alcohol) with polyfunctional aldehydes. Membranes prepared from emulsions of vinyl pyrrolidone-ethyl acrylate and vinyl pyrrolidone-styrene copolymers had exceptionally high urea and creatinine dialysis rates, but were deficient in uric acid transfer. This shortcoming was corrected by incorporating solutes such as sucrose into the membranes followed by leaching. Another important approach concerned the development of a relatively high-strength membrane based on an impermeable nylon resin. Permeability of these membranes which have dialysis characteristics superior to those currently used was obtained through the addition of DMSO and one of several other additives to the coating solution.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820010109
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