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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.
    Abstract: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).
    Type of Medium: Online Resource
    Pages: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031229039
    Series Statement: Current Cancer Research,
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Treatment. ; Neurosciences. ; Immunotherapy. ; Cancer Biology. ; Cancer Therapy. ; Neuroscience. ; Cancer Microenvironment. ; Immunotherapy.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.
    Abstract: This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.
    Type of Medium: Online Resource
    Pages: XII, 202 p. 21 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324291
    DDC: 571.978
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Immunotherapy. ; Cancer Genetic aspects. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Tumour Immunology. ; Immunotherapy. ; Cancer Genetics and Genomics. ; Cancer Stem Cells.
    Description / Table of Contents: Interdisciplinary Approach in Hepatobiliary Cancers -- Liver Cancer: Interdisciplinary Approach -- The Immune System in Liver Cancer: From Beginning to Progression -- The Tumor Microenvironment in Hepatocellular Carcinoma -- Metabolic Alterations of Hepatocellular Cancer Stem Cells -- Τhe Role of Senescence in NASH-related HCC -- Regulators of Genetic Risk for the Progression of Non-alcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Reconstruction of Transcriptional Network and Signature-Based Metabolic Profiling -- Tumor Microenvironment and Immunotherapy in Advanced Biliary Tract Cancers -- Fibrosis and Immunotherapy in Hepatocellular Carcinoma -- Liver Cancer and the Curative Potential of Nanomedicine -- Locoregional Therapies for Hepatocellular Carcinoma -- Drug Resistance in Hepatocellular Carcinoma -- Liver Stereotactic Body Radiotherapy.
    Abstract: Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.
    Type of Medium: Online Resource
    Pages: XI, 365 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031445286
    Series Statement: Interdisciplinary Cancer Research, 3
    DDC: 571.978
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Cancer. ; Cancer Treatment. ; Oncology. ; Immunotherapy. ; Tumors Immunological aspects. ; Nanomedicine. ; Cancer Biology. ; Cancer Therapy. ; Oncology. ; Immunotherapy. ; Tumour Immunology. ; Cancer Nanotechnology.
    Description / Table of Contents: Interdisciplinary Approach in Gastrointestinal Cancers -- Gastrointestinal Cancers: What Is the Real Board of Microenvironment and the Role of Microbiota-Immunity Axis -- Epithelial-Mesenchymal Transition in Gastrointestinal Cancer: From a Basic to a Clinical Approach -- Metabolomics of Gastrointestinal Cancers -- Deregulation of Immune System in Gastric Cancer Development, How Immune Nutrition Might Restore the Functions of Immune Cells -- Helicobacter pylori Virulence Factors, Pathogenicity, and Gastric Cancer -- Gastric Cancer and Helicobacter pylori -- Role of Neuromodulators in Regulation of the Tumor Microenvironment of Gastric and Colorectal Cancers -- The Role of Tumor Microenvironment in Colon Cancer -- Unraveling the Esophageal Cancer Tumor Microenvironment: Insights and Novel Immunotherapeutic Strategies -- The Interplay Between Immunity and Gut Microbiota in Colon Cancer -- Immunotherapy in Gastrointestinal Cancer Focusing on CAR-T Cell Therapy -- Development of Biocompatible Nanocarriers for the Treatment of Colorectal Cancer -- Challenges of Onco-therapeutics in Early Onset Colorectal Cancer -- Unintentional Weight Loss and Malnutrition After Esophageal Cancer and Treatment -- Current Clinical Landscape of Immunotherapeutic Approaches in Pancreatic Cancer Treatment. The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy. .
    Abstract: Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.
    Type of Medium: Online Resource
    Pages: XI, 404 p. 22 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031483714
    Series Statement: Interdisciplinary Cancer Research, 4
    DDC: 571.978
    Language: English
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  • 5
    Keywords: Cancer. ; Oncology. ; Medical screening. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Oncology. ; Cancer Screening. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Chapter 1. Introduction: The Application of AI in Precision Oncology: Tailoring Diagnosis, Treatment, and the Monitoring of Disease Progression to the Patient -- Part I. Artificial Intelligence for Screening, Diagnosis, Monitoring in Precision Oncology -- Chapter 2. Application of AI in Novel Biomarkers Detection that Induce Drug Resistance, Enhance Treatment Regimens and Advancing Precision Oncology -- Chapter 3. Use of Artificial Intelligence in Implementing Mainstream Precision Medicine to Improve Traditional Symptom-driven Practice of Medicine: Allowing Early Interventions and Tailoring better-personalized Cancer Treatments -- Chapter 4. AI as a Novel Approach for Exploring ccfNAs in Personalized Clinical Diagnosis and Prognosis: Providing Insight into the Decision-Making in Precision Oncology -- Chapter 5. AI-Enhanced Digital Pathology and Radiogenomics in Precision Oncology -- Part II. Artificial Intelligence and Omics in Precision Oncology -- Chapter 6. Epigenetics Analysis Using Artificial Intelligence in the Era of Precision Oncology -- Chapter 7. Association of Metabolomics with AI in Precision Oncology: Emerging Perspectives for More Effective Cancer Care -- Chapter 8. Artificial Intelligence Application to Microbiomics Data for Improved Clinical Decision Making in Precision Oncology -- Part III. Artificial Intelligence in Cancer Therapy and the Clinical Applications -- Chapter 9. AI and Nanotechnology in Realizing the Goal of Precision Medicine: Tailoring the Best Treatment for Personalized Cancer Treatment -- Chapter 10. Artificial Intelligence-Based Medical Devices Revolution in Cancer Screening: Impact into Clinical Practice -- Chapter 11. Intelligent Drug Design and Use for Cancer Treatment: The Roles of AI and Precision Oncology in Targeting Patient-Specific Splicing Profiles -- Chapter 12. Applying Artificial Intelligence Prediction Tools for Advancing Precision Oncology in Immunotherapy: Future Perspectives in Personalized Care -- Chapter 13. Employing AI-Powered Decision Support Systems in Recommending the Most Effective Therapeutic Approaches for Individual Cancer Patients: Maximizing Therapeutic Efficacy -- Chapter 14. AI-Pathway Companion in Clinical Decision Support: Enabling Personalized and Standardized Care Along Care Pathways in Oncology -- Chapter 15. AI Tools Offering Cancer Clinical Applications for Risk Predictor, Early Detection, Diagnosis, and Accurate Prognosis: Perspectives in Personalised Care -- Chapter 16. Conclusion and Insights into the Future of AI in Precision Oncology.
    Abstract: This book highlights the use of artificial intelligence (AI), big data and precision oncology for medical decision making in cancer screening, diagnosis, prognosis and treatment. Precision oncology has long been thought of as ideal for the management and treatment of cancer. This strategy promises to revolutionize the treatment, control, and prevention of cancer by tailoring tests, treatments and predictions to specific individuals or population groups. In order to accomplish these goals, vast amounts of patient or population group specific data needs to be integrated and analysed to be able to identify key patterns or features which can be used to define or characterize the disease or the response to the disease in these individuals. These patterns or features can be as varied as molecular patterns or features in medical images. This level of data analysis and integration can only be achieved through the use of AI. The book is divided into three parts starting with a section on the use of artificial intelligence for screening, diagnosis and monitoring in precision oncology. The second part: Artificial intelligence and Omics in precision oncology, highlights the use of AI and epigenetics, metabolomics, microbiomics in precision oncology. The third part covers artificial intelligence in cancer therapy and its clinical applications. It also highlights the use of AI tools for risk prediction, early detection, diagnosis and accurate prognosis. This book, written by experts in the field from academia and industry, will appeal to cancer researchers, clinical oncologists, pathologists, medical students, academic teaching staff and medical residents interested in cancer research as well as those specialising as clinical oncologists.
    Type of Medium: Online Resource
    Pages: XIV, 315 p. 64 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031215063
    DDC: 571.978
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.
    Description / Table of Contents: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.
    Abstract: This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.
    Type of Medium: Online Resource
    Pages: XXI, 542 p. 229 illus., 221 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031162862
    DDC: 571.978
    Language: English
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  • 7
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancers. ; Cancer Therapy. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Chapter 1 An introduction to breast cancer -- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators -- Chapter 4 Cell cycle and cancer -- Chapter 5 cell cycle dysregulation in breast cancer -- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation -- Chapter 7 Breast tumor micro environment and CDks -- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis -- Chapter 9 CDK1 Dysregulation in Breast Cancer -- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers -- Chapter 11 Therapeutic implications of CDKs in Breast Cancer -- Chapter 12 Novel CDK Inhibitors in Breast Cancer -- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach -- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer -- Chapter 15 CDk inhibitor for treatment of breast cancer -- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer -- Chapter 17 Different cyclins and their significance in Breast cancer.
    Abstract: This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.
    Type of Medium: Online Resource
    Pages: XVII, 373 p. 133 illus., 92 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811989117
    DDC: 571.978
    Language: English
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  • 8
    Keywords: Cancer. ; Cancer Genetic aspects. ; Oncology. ; Therapeutics. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Oncology. ; Therapeutics.
    Description / Table of Contents: Chapter 1 Evolution of translational cancer therapeutics -- Chapter 2 Oncology: Way forward from clinical and molecular diagnosis to treatment -- Chapter 3 Oncogenic genomics alterations in cancer patient -- Chapter 4 Altered mRNA expression profiles in cancer patients -- Chapter 5 microRNAs and long non-coding RNAs as key targets -- Chapter 6 Oncogenic alterations translated into diagnostics -- Chapter 7 Precision medicine in oncology -- Chapter 8 Precision medicine – translation of individualistic treatment in oncology -- Chapter 9Pharmacogenetics and Pharmacogenomics in Precision Medicine -- Chapter 10 Pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines -- Chapter 11 Biomarkers in Precision Medicine in oncology -- Chapter 12 Bioinformatics and biostatistics in Precision Medicine -- Chapter 13 Omics in Precision medicine -- Chapter 14 Translational therapeutic targets : from bench to clinical trials -- Chapter 15 Strength of integartive genomic alterations, precision medicine and therapeutic targets as treatment choice in patient care.
    Abstract: This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.
    Type of Medium: Online Resource
    Pages: XVI, 274 p. 23 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819915293
    DDC: 571.978
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Cancer. ; Cancer Treatment. ; Stem cells. ; Cytology. ; Medical genetics. ; Immunology. ; Cancer Biology. ; Cancer Therapy. ; Cancer Stem Cells. ; Cell Biology. ; Medical Genetics. ; Immunology.
    Description / Table of Contents: Interdisciplinary Approaches in Cancer Research -- Role of Immune Cells in the Tumor Microenvironment -- Spatial Transcriptomic Approaches for Understanding the Tumor Microenvironment (TME) -- Role of Mesenchymal Stem/Stromal Cells in Cancer Development -- Cancer-associated Fibroblasts and Their Role in Cancer Progression -- The Role of Tumoroids in Cancer Research -- Myokines Expression in Cancer Cachexia -- Epigenetics in Cancer Biology -- Epigenetic Regulation of Cancer by Natural Touch: Phytochemicals and Epigenetic Regulation -- Telomerase Reverse Transcriptase in Humans: From Biology to Cancer Immunity -- Molecular Mechanisms of Metal-induced Carcinogenesis -- Epi-drugs Targeting RNA Dynamics in Cancer -- Oncologic Emergencies: Pathophysiology, Diagnosis, and Initial Management -- Malignancies in Inborn Errors of Immunity -- Hematopoietic Stem Cell Transplantation in Patients with Inborn Errors of Immunity and Malignancy -- Personalized Immuno-oncology with Immunodeficiency Mouse Models -- Allergy and Cancer: New Perspectives -- Depression and Cancer: the Inflammatory Bridge -- Impact of Cancer-Related Sarcopenia on Systemic Immune Status -- Surveillance of Subclinical Cardiovascular Complications in Childhood Cancer Survivors: Exercise as a Diagnostic and Therapeutic Modality.
    Abstract: Cancer is a major public health concern and one of the leading causes of death. There is no simple solution for this complex disease, therefore interdisciplinary approaches might help to find solutions to many unanswered questions and challenges about cancer. The rapid flow of interdisciplinary research in cancer during recent years has increased our understanding of the nature of cancers. Such interdisciplinary approaches could be helpful for both the diagnosis and the development of more effective therapeutic strategies. The “Interdisciplinary Cancer Research” series publishes comprehensive volumes on different cancers and presents the most updated and peer-reviewed articles on human cancers. Over the past decade, increased cancer research has greatly improved our understanding of the nature of cancerous cells which has led to the development of more effective therapeutic strategies to treat cancers. This interdisciplinary series is of special value to researchers and practitioners working on cell biology, immunology, hematology, biochemistry, genetics, oncology and related fields. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN).
    Type of Medium: Online Resource
    Pages: XI, 611 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324581
    Series Statement: Interdisciplinary Cancer Research, 1
    DDC: 571.978
    Language: English
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  • 10
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Buildings Repair and reconstruction. ; Buildings Maintenance. ; Construction industry Management. ; Geotechnical Engineering and Applied Earth Sciences. ; Building Repair and Maintenance. ; Construction Management.
    Description / Table of Contents: Introduction -- Measurement and Analysis of Ground Settlement of Shield Tunneling Adjacent to Different Foundation Buildings -- Calculation of Soil Deformation Caused by Shield Tunneling -- Studies the Influence of Longitudinal Tunneling of Shield on Adjacent Shallow Foundation Buildings -- Research on the Influence of Shield Longitudinal Excavation Adjacent to Short Pile Foundation Buildings -- Research on the Influence of Double-line Shield tunneling Adjacent to Buildings and Control Standards -- Prediction of Lateral Ground Settlement Caused by Shield Tunneling Adjacent to Buildings -- Construction Control Technology of Shield Tunneling Adjacent to Structures.
    Abstract: This book introduces the synergy theory model to analyze the calculation results of the soil deformation and the lateral displacement law caused by the longitudinal shield tunneling based on in-depth scientific research and engineering practice on deformation of structures caused by shield tunneling. The influence of shield tunneling on different adjacent foundation buildings was studied, and the deformation law and internal force distribution law of the structures were obtained. It aims to help practitioners in understanding the mechanism, predictive analysis method, and corresponding control technology of the influence of surrounding structures’ deformation caused by shield tunneling.
    Type of Medium: Online Resource
    Pages: XV, 247 p. 191 illus., 92 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811911347
    DDC: 624.151
    Language: English
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  • 11
    Keywords: Geotechnical engineering. ; Engineering geology. ; Natural disasters. ; Environmental management. ; Geotechnical Engineering and Applied Earth Sciences. ; Geoengineering. ; Natural Hazards. ; Environmental Management.
    Description / Table of Contents: Foreword -- Chapter 1 Introduction -- Chapter 2 Classification and geological identification of hazard-causing system for water and mud inrush in tunnel -- Chapter 3 Typical cases and analysis of water and mud inrush in tunnel -- Chapter 4 Route selection of tunnel in karst area -- Chapter 5 Interval dynamic risk assessment of water and mud rush in tunnel construction -- Chapter 6 Resistance body assessment method against water and mud inrush in tunnel -- Chapter 7 Identification method of water and mud inrush hazard-causing system in tunnel -- Chapter 8 Dynamic management and analysis platform of water and mud inrush cases in tunnel -- References -- Appendix.
    Abstract: This book is composed of eight chapters, introducing the authors’ research and application achievements in the hazard-causing system and disaster evaluation of water and mud inrush in tunnels over the past 10 years. Through a large number of case studies and analysis, and on the basis of existing research, this book puts forward 3 categories and 11 types of tunnel water and mud inrush hazard-causing systems and 4 typical water and mud inrush disaster-forming modes. The authors carefully study the typical cases of tunnel water and mud inrush hazard-causing system, discuss the types of karst water system, structural characteristics, macro-geological identification, engineering identification, karst tunnel route selection principles and evaluation methods in detail, and then develop a dynamic evaluation method of tunnel water and mud inrush construction risk interval and an evaluation method for the resistance body. Ultimately, the authors put forward a systematic identification method of tunnel water and mud inrush disaster, which integrates geological identification, geophysical exploration identification, and drilling identification, and construct a dynamic management and analysis platform for tunnel water and mud inrush cases. This book is used as a reference book for teachers, graduate students, and undergraduates in colleges and universities of civil engineering, transportation, water conservancy and hydropower, mining, geology, etc., and also as a reference for technicians in related engineering fields.
    Type of Medium: Online Resource
    Pages: XIII, 408 p. 114 illus., 104 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811995231
    DDC: 624.151
    Language: English
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  • 12
    Keywords: Geotechnical engineering. ; Water. ; Hydrology. ; Cogeneration of electric power and heat. ; Fossil fuels. ; Earth sciences. ; Rock mechanics. ; Soil mechanics. ; Geotechnical Engineering and Applied Earth Sciences. ; Water. ; Fossil Fuel. ; Earth Sciences. ; Soil and Rock Mechanics.
    Description / Table of Contents: Chapter 1: Introduction to the Discrete Element Method (DEM) and Related Fluid Mechanics Concepts -- Chapter 2: Discrete Element Modeling of Hydraulic Fracturing -- Chapter 3: DEM Coupled with Computational Fluid Dynamics (CFD) -- Chapter 4: DEM Coupled with Dynamic Fluid Mesh (DFM) -- Chapter 5: DEM Coupled with Lattice-Boltzmann Method (LBM) -- Chapter 6: Hydraulic Stimulation of Naturally Fractured Reservoirs -- Chapter 7: Models of Stimulation and Production from Enhanced Geothermal Systems -- Chapter 8: Hydraulic Fracturing Induced Fault Reactivation -- Chapter 9: 3D Lattice Modeling of Hydraulic Fracturing in Naturally Fractured Reservoirs -- Chapter 10: Heat Advection and Forced Convection in a Lattice Code -- Chapter 11: Near Wellbore HF Propagation for Different Perforation Models -- Chapter 12: Design of Extreme Limited Entry Perforation.
    Abstract: The subject of thermo-hydro-mechanical coupled processes in fractured rock masses has close relevance to energy-related deep earth engineering activities, such as enhanced geothermal systems, geological disposal of radioactive waste, sequestration of CO2, long-term disposal of waste water and recovery of hydrocarbons from unconventional reservoirs. Despite great efforts by engineers and researchers, comprehensive understanding of the thermo-hydro-mechanical coupled processes in fractured rock mass remains a great challenge. The discrete element method (DEM), originally developed by Dr. Peter Cundall, has become widely used for the modeling of a rock mass, including its deformation, damage, fracturing and stability. DEM modeling of the coupled thermo-hydro-mechanical processes in fractured rock masses can provide some unique insights, to say the least, for better understanding of those complex issues. The authors of this book have participated in various projects involving DEM modeling of coupled thermo-hydro-mechanical processes during treatment of a rock mass by fluid injection and/or extraction and have provided consulting services to some of the largest oil-and-gas companies in the world. The breadth and depth of our engineering expertise are reflected by its successful applications in the major unconventional plays in the world, including Permian, Marcellus, Bakken, Eagle Ford, Horn River, Chicontepec, Sichuan, Ordos and many more. The unique combination of the state-of-the-art numerical modeling techniques with state-of-the-practice engineering applications makes the presented material relevant and valuable for engineering practice. We believe that it is beneficial to share the advances on this subject and promote some further development.
    Type of Medium: Online Resource
    Pages: XIX, 306 p. 227 illus., 201 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031257872
    DDC: 624.151
    Language: English
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  • 13
    Keywords: Geotechnical engineering. ; Natural disasters. ; Engineering design. ; Engineering geology. ; Sustainability. ; Geotechnical Engineering and Applied Earth Sciences. ; Natural Hazards. ; Engineering Design. ; Geoengineering. ; Sustainability.
    Description / Table of Contents: Introduction -- Terms and Notations -- Performance-based Seismic Design of Slope -- Seismic Ground Motion Excitations for Slope Seismic Dynamic Performance Design and Assessment -- Deterministic Analysis Methods for Slope Seismic Dynamic Response -- Probabilistic Performance-based Seismic Design and Assessment for Slope Engineering -- Case Study -- Conclusions and Prospects.
    Abstract: This book provides a new design and evaluation framework based on slope Stochastic Dynamics theory to probabilistic seismic performance for slope engineering. For the seismic dynamic stability safety of slope, it shifts from deterministic seismic dynamic analysis to quantitative analysis based on nonlinear stochastic dynamics, that is, from qualitative to the description of stochasticity of earthquake excitation that meet the needs in related design specification and establish a performance standard. In the nonlinear dynamic time history analysis of slope subjected to seismic ground motion, the term “randomness” is used to express the uncertainty in the intensity and frequency of earthquake excitation for slope engineering dynamic seismic performance. It mainly includes seismic design fortification standard, corresponding ground motion excitation, performance index threshold, and slope deterministic nonlinear seismic dynamic response. Even more than that, the seismic dynamic large deformation approaches of the whole process and comprehensive analysis for flow analysis after slope instability failure. Eventually, the probabilistic seismic dynamic performance of the slope engineering will be characterized by nonlinear dynamic reliability.
    Type of Medium: Online Resource
    Pages: XVII, 134 p. 51 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811991837
    DDC: 624.151
    Language: English
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  • 14
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Underground construction. ; Geotechnical Engineering and Applied Earth Sciences. ; Underground Engineering and Tunnel Construction.
    Description / Table of Contents: 1. Introduction -- Risk control system for subsea tunnels -- 3. Composite grouting technology and its application -- 4. Water inrush mechanism and evolution characteristics -- 5. Process control theory of construction safety -- 6. Active controlled waterproof-drainage system and its design method.
    Abstract: This book puts forward a technological system for the construction of subsea tunnel using drilling and blasting method. Taking the water-induced disaster as the core risk, the safety guarantee system for large cross-sectional subsea tunnels is established. The composite grouting technology referred to ground reinforcement and water plugging is established, which breaks through the technical bottleneck of subsea tunnel construction in highly permeable strata. The process control theory based on water inrush mechanism is created, which gets rid of the over-dependence on engineering experience for disaster control of submarine tunnel. An active control waterproof drainage system based on the synergy of reinforcement ring and support system is invented to solve the contradiction between the control of water displacement and water pressure. The above-mentioned achievements have been successfully applied in the first three large cross-sectional subsea tunnels in China, and have played a key role in the construction safety. The proposed technological system can improve the overall construction level of subsea tunnel, which can provide reference for the design and construction of subsea tunnels, especially for those crossing through weakness zones.
    Type of Medium: Online Resource
    Pages: XVI, 405 p. 265 illus., 209 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811987533
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Surfaces (Technology). ; Thin films. ; Fluid mechanics. ; Condensed matter. ; Soft condensed matter. ; Geotechnical Engineering and Applied Earth Sciences. ; Surfaces, Interfaces and Thin Film. ; Engineering Fluid Dynamics. ; Phase Transitions and Multiphase Systems. ; Soft and Granular Matter.
    Description / Table of Contents: Introduction -- Electrospun Fibrous Mats -- Tailored Electrospun Gas Diffusion Layers With a Graded Pore Structure for Polymer Electrolyte Membrane Fuel Cells -- Dispersed Nanostructured Thin Film (Dnstf) Catalyst -- Electrochemical Actuation of a Nanoporous Polypyrrole Hybrid Material -- Laser-Excited Elastic Guided Waves Reveal the Complex Mechanics of Nanoporous Silicon -- Sample Layout Aiding Efficient Scans of Heterogeneous Sheet-Like Materials -- Protective Porous Media - The Pore & Fiber Structure of Face Masks -- Individual Fibers in Nonwoven are Identified with Artificial Intelligence -- Mechanism of Imperfect Atomic Layer Deposition in Porous Materials -- Mass Transport in Conformally Coated Porous Materials -- Optical Microfabrication of Porous Films -- Bicontinuous Porosity by Spinodal Phase Separation -- Nucleation and Crystal Growth on the Secondary Substrate -- Double-Porosity in Soil -- Boreal Mosses and Lichens -- The Gorgonian Octocoral Eunicella Cavolinii Forms a Porous Biological Material with Outstanding Material Properties -- Foraminifer -- Trovants: The “Living” Stones of Romania Formed as High Porosity Spherical Sandstone Concretions Developed Around a Fossil -- The Complex Pore Spaces of Our Brain: A Challenge and Opportunity for Computer Simulations -- Scaling and Resolution Effect of an Andesite Sample -- Length-Scale Dependence of Pore Space Topology -- Microstructure of Crushable Expanded Clay Aggregates -- Reticulated Rutile -- Mineral Map of Rotliegendes -- Boise Brown -- North Netherlands Gas Reservoir -- Fib-Sem Images From a Cathode Material: Unfiltered and Filtered (Curtaining Filter) -- Vesicles and Fractures in Volcanic Ash -- A View of the Internal Pore Structure of a Volcanic Rock: Xaltipan Ignimbrite -- In Situ Microtomography of the Tensile Fracture and Fragmentation of Porphyry Copper Ores -- Fractured Porous Media: A Cretaceous Carbonate Outcrop Sample -- Fracture Network in a Shale Cube Hydraulically Fractured in the Laboratory -- Geological Carbon Storage at the University of Bergen, Norway.
    Abstract: Graphical depictions of abstract concepts have played a major role in the formulation and communication of ideas since prehistoric times. The invention of photography in the nineteenth century and more recent advances in visualization techniques have catalyzed an enormous wealth of insights into every field of science and engineering by extending our senses far beyond our natural sensorial capabilities. The field of porous media has also benefited enormously from these developments in visualization techniques. Indeed, improvements in these techniques have led to the better morphological characterization of porous media and an enhanced understanding of the assorted physical processes, such as mass transport, capillarity, swelling, and fracturing, that can occur at the pore level. These observations, in turn, have led to superior usage practices for existing porous materials and the design of new products with porous media. Therefore, this bilingual English-Spanish album is aimed at providing a collection of state‐of‐the‐art visualizations of the diverse aspects of porous media that will serve as a reference in education and research. To cover all these aspects properly, the album is organized into seven thematic parts. Each part includes a collection of chapters with images accompanied by a brief English-Spanish description of the novelty of the observation, the visualization technique used, and the phenomenological insights gained. Las representaciones gráficas de conceptos abstractos han jugado un papel importante en la formulación y comunicación de ideas desde tiempos prehistóricos. La invención de la fotografía en el siglo XIX y los avances más recientes en las técnicas de visualización han catalizado una enorme riqueza de conocimientos en todos los campos de la ciencia y la ingeniería al extender nuestros sentidos mucho más allá de nuestras capacidades sensoriales naturales. El campo de los medios porosos también se ha beneficiado enormemente de estos avances en las técnicas de visualización. De hecho, las mejoras en estas técnicas han llevado a una mejor caracterización morfológica de los medios porosos y una mejor comprensión de los diversos procesos físicos, como el transporte de masa, la capilaridad, la hinchazón y la fractura, que pueden ocurrir a nivel de poro. Estas observaciones, a su vez, han llevado a mejores prácticas de uso para los materiales porosos existentes y al diseño de nuevos productos con medios porosos. Por lo tanto, este álbum bilingüe inglés y español tiene como objetivo proporcionar una colección de visualizaciones del estado del arte de los diversos aspectos de los medios porosos que servirán como referencia en la educación y la investigación. Para cubrir adecuadamente todos estos aspectos, el álbum está organizado en siete partes temáticas. Cada parte incluye una colección de capítulos con imágenes acompañadas de una breve descripción en inglés y español de la originalidad de la observación, la técnica de visualización utilizada y los conocimientos fenomenológicos obtenidos.
    Type of Medium: Online Resource
    Pages: XV, 145 p. 119 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031238000
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Buildings Design and construction. ; Engineering geology. ; Geotechnical Engineering and Applied Earth Sciences. ; Building Construction and Design. ; Geoengineering.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Mechanisms of progressive collapse of concrete structures -- Chapter 3. Dynamic increase factor (DIF) of concrete structures -- Chapter 4. Spatial and slab effects on concrete structures -- Chapter 5. Mechanisms of progressive collapse of flat slab structures -- Chapter 6. Performance of infilled frames during progressive collapse -- Chapter 7. Vulnerability and robustness of RC frames to resist progressive collapse.
    Abstract: The book introduces the comprehensive analysis methodology regarding progressive collapse, and the critical issues may happen in concrete structures. Main topics include: the influential parameters of the development of the main load-resisting mechanisms; the dynamic effects with sudden column removal scenarios; the contribution of non-structural components to improve the resilience of concrete structures; uncertainties in progressive collapse analysis. Based on the empirical research of the author and his team, the book provides valuable knowledge in the field of progressive collapse and bridges the gap between academic research and practice.
    Type of Medium: Online Resource
    Pages: XII, 278 p. 224 illus., 179 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819907724
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Petrology. ; Rock mechanics. ; Soil mechanics. ; Mining engineering. ; Mathematical models. ; Geotechnical Engineering and Applied Earth Sciences. ; Petrology. ; Soil and Rock Mechanics. ; Mining and Exploration. ; Mathematical Modeling and Industrial Mathematics.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Establishing a high resolution 3D fracture dataset in chalk: possibilities and obstacles working with outcrop data -- Chapter 3. Calibration and applications of a rate-dependent geomechanical model for Danian and Maastrichtian reservoir chalk (Danish North Sea) -- Chapter 4. Deformation induced variations in porosity of the Chalk Group in the North Sea Basin -- Chapter 5. Strain evolution of the Kraka Chalk inferred from stratigraphic reconstruction -- Chapter 6. Improved visualization of structural deformation on the Kraka structure (Danish Central Graben) with color-processed seismic data -- Chapter 7. Using geomechanical models to simulate the growth of the fracture network in the Ekofisk Formation of the Kraka structure, Danish Central Graben -- Chapter 8. Geomechanical modelling the evolution of a connected natural fracture network to explain fluid flow variations across a fractured chalk-marl reservoir -- Chapter 9. Numerical study on the influence of induced hydraulic fractures on oil production in a line drive -- Chapter 10. Conclusions.
    Abstract: This book summarizes new discoveries on fracturing in chalk. Based on studies on the Danish North Sea, this book shows how observations from outcrop analogues, core and seismic data can be used to characterize the density, distribution and geometry of natural fractures in chalk and marl. Laboratory experiments on chalk samples reveal the controls on the geomechanical properties of chalk and thus on the growth of natural fractures. Finally, various modeling techniques are employed to investigate the mechanical deformation in the chalk structures of the Danish North Sea and to predict fracture distribution and geometry in the subsurface. An understanding of fracture density, distribution and geometry is essential for planning efficient fluid extraction or injection strategies and CO2 sequestration. This book provides the necessary knowledge.
    Type of Medium: Online Resource
    Pages: VIII, 271 p. 114 illus., 106 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031353277
    Series Statement: Petroleum Engineering,
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Geomorphology. ; Sedimentology. ; Geotechnical Engineering and Applied Earth Sciences. ; Geomorphology. ; Sedimentology.
    Description / Table of Contents: General Introduction: Transportation System and Geomorphic Landscape -- Types and Development of Transportation Infrastructure -- Transportation Infrastructure and Geomorphic Connectivity -- Transportation Infrastructure, Slope Instability, and Soil Erosion -- Transportation Infrastructure and Road Surface Hydrology -- Geomorphological Alteration by Trails and Off-roading Activities.
    Abstract: This book focuses on a significant branch of anthropogeomorphology, which is not adequately studied: the impact of transportation systems on altering earth surface processes and landforms. This book fills the gap with in-depth study on the interaction between individual modes of transport network (e.g., trail, roads, railways, waterways, airports, and tunnel) and surface hydro-geomorphology with intensive literature review, fieldwork, geo-environmental modelling, mapping, case studies, and examples from different parts of the world. On the one hand, this book also addresses the vulnerability of transport networks from climate change and critical geo-hazards like floods, landslides, etc. with case studies from the high-risk zones of India. Overall, this book promotes peaceful harmony between the transport network and its surrounding landscapes as an essential lesson for policymakers, planners, and stakeholders.
    Type of Medium: Online Resource
    Pages: XVI, 244 p. 121 illus., 95 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031378973
    Series Statement: Earth and Environmental Sciences Library,
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Environmental engineering. ; Civil engineering. ; Transportation engineering. ; Traffic engineering. ; Geology. ; Geotechnical Engineering and Applied Earth Sciences. ; Environmental Civil Engineering. ; Transportation Technology and Traffic Engineering. ; Geology.
    Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Composite Girder (the structure of bridge deck) and its applicability -- Chapter 3 Cable-stayed Bridge with Composite Girder -- Chapter 4 Suspension Bridge with Composite Girder -- Chapter 5 Arch Bridge with Combined Deck (or Composite Girder) -- Chapter 6 Construction -- Chapter 7 Mechanical Performance and Economy of Cable-stayed Bridge with Composite Beam -- Chapter 8 Mechanical Performance and Economics of Suspension Bridge with Composite Girder -- Chapter 9 Prospect -- References -- Index.
    Abstract: This book introduces the latest developments in long-span cable-supported composite cable-stayed bridges, suspension bridges, and mid- and through-type cable-supported composite arch bridges. Based on the engineering application and practice of cable-supported composite bridges, this book systematically expounds the structural systems of these bridge types. It also summarizes the main construction methods, analyzes the mechanical properties of cable-stayed bridges and suspension bridges with composite girders and the influence rule with alternative spans, and proposes the reasonable span range based on economic efficiency. The prospect of using orthotropic composite bridge decks in long-span cable-supported bridges is also analyzed. This book is a valuable reference for both bridge professional technicians and graduate students for research, design and construction.
    Type of Medium: Online Resource
    Pages: XVI, 771 p. 949 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819932085
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Stem cells. ; Cytology. ; Developmental biology. ; Cancer Stem Cells. ; Cell Biology. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Assays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis.
    Abstract: This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understanding of the role of autophagy in stem cells, including germline stem cells. Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 41 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031173622
    Series Statement: Stem Cell Biology and Regenerative Medicine, 73
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Biology Technique. ; Stem cells. ; Cancer Biology. ; Biological Techniques. ; Cancer Stem Cells. ; Stem Cell Biology.
    Description / Table of Contents: 1. On the origin of cancer -- 2. Culture of Cells: Basic Principles -- 3. Stem cell culture from embryos -- 4. Reprogramming of normal cells -- 5. Maintenance of human Pluripotent Stem Cells -- 6. Identification of cancer stem cells by different molecular markers -- 7. Enrichment of Cancer Stem Cell from malignant tumor -- 8. Isolation of single clonal cell from primary cultured cells and establishment of a cancer stem cell line -- 9. Artificial Generation of Cancer Stem Cells from Normal Stem Cells -- 10. Quick method to assess non-mutagenic carcinogens with iPS cells -- 11. Self-renewal potential of caner stem cells -- 12. Differentiation potential of cancer stem cells in vitro -- 13. Tumor Angiogenesis by cancer stem cells in vivo -- 14. Invasion and Metastatic potential of cancer stem cells in vitro -- 15. Metastatic potential of cancer stem cells In Vivo- 16. Anchorage-independent cell growth assay for Cancer Stem Cells: Tumorigenic assay in vitro -- 17. Tumorigenic potential of cancer stem cells in vivo -- 18. Development of immunoliposomes using monoclonal antibodies targeting cancer stem cells -- 19. In-vitro evaluation of anti-cancer stem cell drugs -- 20. In vitro Tumoroid Model Using Cancer Stem Cells.
    Abstract: This book describes the use of stem cells and cancer stem cell generation in the inflammatory microenvironment (cancer-inducing niche) using induced pluripotent stem cells. It provides step-by-step techniques and manuals for studying stem cell and cancer stem cell generation with different applications in cancer research. The development of induced pluripotent stem cells has provided a new approach to studying cancer initiation by producing cancer stem cells without introducing mutations or foreign genes. The book features the research of the authors’ group, which was the first to generate cancer stem cells from stem cells in the presence of inflammatory conditions. The 20 chapters if this book cover topics such as generating pluripotent stem cells, converting normal stem cells to cancer stem cells, enriching, isolating and evaluating cancer stem cells. Methods for evaluating the characteristics of cancer stem cells and possible therapies against them are also discussed. The book provides easy-to-follow protocols that help researchers in the study of cancer stem cells. Illustrations help readers understand how the method of cancer stem cell generation can be applied as an essential method for assessing the carcinogenic potential of various non-mutagenic compounds. It will be a useful resource for graduate students, researchers, technicians, and physicians working in academic, hospital, and pharmaceutical settings. .
    Type of Medium: Online Resource
    Pages: XVII, 243 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819913312
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Cancers. ; Cancer Therapy. ; Cancer Biology. ; Tumour Immunology.
    Description / Table of Contents: Chapter 1. Hypoxia and its Biological Implications for Cancer Therapy -- Chapter 2. Hypoxia's function in cancer -- Chapter 3. Role of Hypoxia and Reactive Oxygen Species in cancer biology -- Chapter 4. Hypoxic tumor microenvironment: driver for cancer progression -- Chapter 5. Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression -- Chapter 6. Hypoxia Regulated Gene Expression and Metastasis -- Chapter 7. piRNA based cancer therapy in hypoxic tumor -- Chapter 8. MicroRNA Signatures of Tumor Hypoxia -- Chapter 9. Hypoxia and the Metastatic Cascade -- Chapter 10. Hypoxia and Extra Cellular Matrix-major drivers of tumor Metastasis -- Chapter 11. Role of Hypoxia in Cancer Therapy – Introduction -- Chapter 12. Hypoxic regulation of telomerase gene expression in cancer -- Chapter 13. CRISPR/Cas9-editing-based modeling of tumor hypoxia -- Chapter 14. Tumor-on-a-chip: Microfluidic models for Hypoxic tumor microenvironment -- Chapter 15. Imaging the Hypoxic Tumor microenvironment in cancer models -- Chapter 16. Hypoxia-targeting drugs as new cancer chemotherapy agents Hypoxia-targeting drugs as new cancer chemotherapy agents - Molecular Insights -- Chapter 17. Identification of Hypoxia targeting drugs in the tumor microenvironment and prodrug Strategies for Targeting Tumor Hypoxia -- Chapter 18. Hypoxia Induced Apoptosis in Cancer Development -- Chapter 19. Hypoxia in drug resistance and radioresistance.
    Abstract: This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.
    Type of Medium: Online Resource
    Pages: XV, 447 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819903139
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Animal models. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Models. ; Cancer Therapy. ; Cancer Genetics and Genomics. ; Cancer Microenvironment.
    Description / Table of Contents: Chapter 1: Cancer as a Disease of Cell Proliferation -- Chapter 2: Genetic and Chromosomal Instability -- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function -- Chapter 4: The DNA Damage Checkpoint -- Chapter 5: Dynamics of the Spindle Assembly Checkpoint -- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance -- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy -- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy -- Chapter 9: The Cancer Stem Cell and Tumour Progression -- Chapter 10: Evading the antitumour immune response -- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention -- Chapter 12: In science, all conclusions are provisional.
    Abstract: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.
    Type of Medium: Online Resource
    Pages: XIV, 269 p. 96 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031325731
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Cancer Genetic aspects. ; Cancer Treatment. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1. Breast cancer -- Chapter 1.1. Epidemiology -- Chapter 1.2. Etiology -- Chapter 1.3. Types of breast cancer -- Chapter 1.4. Signs and symptoms -- Chapter 1.5. Stages -- Chapter 1.6. Diagnosis -- Chapter 1.7. Treatment -- Chapter 2. Genetic landscape of breast carcinogenesis -- Chapter 2.1. Hormone receptor positive breast cancer -- Chapter 2.1. Her2 positive breast cancer -- Chapter 2.2. Triple negative breast cancer -- Chapter 3. Epigenetic involvement in breast carcinogenesis -- Chapter 3.1. Histone modification -- Chapter 3.2. DNA methylation -- Chapter 3.3. miRNA -- Chapter 4. Breast cancer control -- Chapter 4.1. Conventional drugs targeting Genetic and Epigenetics in Breast cancer -- Chapter 4.2. Pitfalls of conventional therapy -- Chapter 4.3. Natural remediation -- Chapter 5. Conclusion.
    Abstract: This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment.
    Type of Medium: Online Resource
    Pages: X, 87 p. 13 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811999253
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Stem cells. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Stem Cells. ; Cancer Therapy. ; Cancer Biology. ; Cancer Genetics and Genomics.
    Description / Table of Contents: 1. Introduction and perspective in carcinogenesis -- 2. Origin and Development of Cancer Stem Cells -- 3. Detection and Isolation of Cancer Stem Cells -- 4. The genetic and epigenetic landscape of cancer stem cells -- 5. Metabolism of Cancer Stem Cell -- 6. Plasticity of Cancer Stem Cell -- 7. Cancer Stem Cells in Cancer Initiation and Progression -- 8. Cancer Stem Cells and Metastasis -- 9. Roles of Cancer Stem Cells in Therapy resistance and Disease Recurrence -- 10. Novel therapeutics targeting cancer stem cell surface markers -- 11. Therapeutics targeting cancer stem cells signalling pathways -- 12. Cancer stem cells therapeutics delivery and EPR effect -- 13. Immunotherapy against cancer stem cells -- 14. Engineering nanobody targeting cancer stem cells -- 15. Biological barriers for drug delivery to cancer stem cells -- 16. Cancer Stem Cell Markers in Haematological Malignancies -- 17. Diagnostic and Prognostic Significance of Cancer Stem Cells Surface Markers -- 18. Diagnostic and prognostic implications of cancer stem cells transcription factors -- 19. Diagnostic and prognostic significance of intracellular markers of CSCs in patients with cancers. .
    Abstract: This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.
    Type of Medium: Online Resource
    Pages: XVI, 372 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819931859
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Tumors Immunological aspects. ; Therapeutics. ; Cancers. ; Tumour Immunology. ; Therapeutics.
    Description / Table of Contents: Chapter 1_Introduction to Cancer -- Chapter 2_Expression pattern of Chemokines in Cancer -- Chapter 3_Implications of Cytokine-Chemokine Heterogenity in Cancer -- Chapter 4_Cytokine and chemokines networks in cancer stemness -- Chapter 5_Cytokine and chemokines networks in angiogeneis -- Chapter 6_Role of Cytokine-Chemokine cascades in Epithelial to Mesenchymal Transition -- Chapter 7_Role of Chemokines in establishment of Metastatic Niche -- Chapter 8_CXCL12-CXCR4 axis in Metastasis -- Chapter 9_Chemokine and cytokine networks in the tumor microenvironment -- Chapter 10_CXCL9, CXCL10, CXCL11/CXCR3 axis and Immune Activation -- Chapter 11_CXCL8-CXCR1/2 axis in cancer and inflammatory diseases -- Chapter 12_Cytokine and Chemokine Networks in Therapeutic Resistance -- Chapter 13_Prognostic and diagnostic significance of Chemokines and cytokines in cancer -- Chapter 14_Therapeutic implications of Chemokines and cytokines networks in cancer -- Chapter 15_Chemokines in cancer therapy.
    Abstract: Cytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.
    Type of Medium: Online Resource
    Pages: XVII, 440 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819946570
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Metabolism. ; Cancer Treatment. ; Biochemistry. ; Oxidation-reduction reaction. ; Cancer Metabolism. ; Cancer Therapy. ; Redox Biology.
    Description / Table of Contents: 1. ROS, redox regulation and signaling in cancer cells -- 2. ROS and redox regulation/signaling and metabolism in cancer stem cells -- 3. . ROS/Redox regulation with dietary phytochemicals and role in anticancer activity -- 4. ROS/Redox signaling and apoptosis/necroptosis/autophagy in cancer -- 5. Cancer Metastasis, ROS/redox signaling and PCD resistance/redox metabolism -- 6. Immune system, redox signaling and cancer immunity -- 7. P53, ROS- redox regulation signaling, metabolic reprogramming and autophagy in cancer -- 8. Cell cycle, DNA damage-repair systems and impact of redox regulation in cancer -- 9. ROS, redox regulation and anticancer therapy -- 10. Perspectives in ROS/redox regulation cancer therapy.
    Abstract: This book aims to provide an association of the major redox-sensitive pathways and networks involved in cancer. The initial chapter of the book discusses basic information about oxidative stress, its generation, and regulation (redox regulation or redox homeostasis) via cell signaling in normal and cancer cells. The book also explores antioxidants and metabolic events in cancer cells compared to normal cells. It further covers the application of nanoparticles in redox regulation in cancer cells. The role of redox regulation in cancer therapy, its influence, and its involvement in programmed cell death (PCD), metastasis, immune system, p53, and cell cycle/DNA damage repair pathways have been discussed in separate chapters. It further reviews the importance of dietary phytochemicals in redox regulation in normal and cancer pathophysiology. Towards the end, the book focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells.
    Type of Medium: Online Resource
    Pages: XI, 431 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819973422
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Geophysics. ; Sedimentology. ; Geotechnical Engineering and Applied Earth Sciences. ; Geophysics. ; Sedimentology.
    Description / Table of Contents: Chapter 1. Definitions, History, and Differentiating Characteristics of Shale Hydrocarbon Recovery -- Chapter 2. Drilling, Completion, and Monitoring Operations -- Chapter 3. Reserve Estimation Through Rate-time Analysis -- Chapter 4. Rate-pressure-time Analysis for Reserve Estimation.
    Abstract: The main focus of this book is to show the challenges specific to shale hydrocarbon recovery and the practices to overcome these challenges. This book starts with an overview to the technological evolution that led to successful production of shale plays, and the implications of the shale being a source rock for its hydrocarbon recovery. The second chapter presents the operations of well drilling, hydraulic fracturing, and monitoring activities. Chapter 3 provides an overview of the available methods for reserve estimation of shale resources followed by comprehensive coverage of decline curve analysis (DCA). In a departure from the mostly empirical rate-time DCA methods covered in Chapter 3, advanced rate-time-pressure analysis – often referred to as rate transient analysis (RTA) - methods are presented in Chapter 4. Chapter 4 ends with discussing the complications of fluid flow in shale reservoirs and the required modeling improvements.
    Type of Medium: Online Resource
    Pages: VIII, 78 p. 43 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031235597
    Series Statement: SpringerBriefs in Earth Sciences,
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Geophysics. ; Cogeneration of electric power and heat. ; Fossil fuels. ; Fluid mechanics. ; Industrial engineering. ; Production engineering. ; Energy policy. ; Energy and state. ; Geotechnical Engineering and Applied Earth Sciences. ; Geophysics. ; Fossil Fuel. ; Engineering Fluid Dynamics. ; Industrial and Production Engineering. ; Energy Policy, Economics and Management.
    Description / Table of Contents: Chapter 1: Reservoir Characteristics, Storage and Percolation Capacities of Ultradeep Carbonate Gas Reservoirs -- Chapter 2: Percolation Mechanism of Ultradeep Carbonate Gas Reservoir -- Chapter 3: Stress Sensitivity Characteristics of Ultradeep Carbonate Gas Reservoir -- Chapter 4: Gas Production Characteristics of Ultradeep Carbonate Gas Reservoir.
    Abstract: This book provides a systematical investigation on the reservoir characteristics and percolation mechanism of ultradeep carbonate gas reservoirs, including reservoir characteristics and classification, gas storage and percolation capacities, gas-phase and gas-water two-phase percolation mechanism, microscale complex gas-water relationship, reservoir sensitivity characteristics, and gas production characteristics of heterogeneous carbonate reservoirs. Some advanced and improved experimental techniques and analytical methods are introduced and applied, including comprehensive evaluation technique of storage and percolation capacities, ultra-high temperature and pressure physical simulation experiment technique, microscopic visualization technique based on CT scanning and microelectronics lithography, and physical simulation technique for heterogeneous reservoir development. In addition, it summarizes strategies for the efficient development of ultradeep carbonate gas reservoirs based on these theoretical research results. The key techniques and methods introduced in this monograph satisfy the need for efficient development of ultradeep carbonate gas reservoirs and provide theoretical basis and methodological value for investigations on similar gas reservoirs. This book serves as a reference for engineering technical professionals, researchers, and graduate students who are engaged in the exploration and development of carbonate gas reservoirs.
    Type of Medium: Online Resource
    Pages: XV, 325 p. 194 illus., 191 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811997082
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Geology. ; Geophysics. ; Petrology. ; Geotechnical Engineering and Applied Earth Sciences. ; Geology. ; Geophysics. ; Petrology.
    Description / Table of Contents: Preliminary study of the opportunity to predict changes in rock samples inner structure caused by triaxial loading based on stress-strain relationship -- Estimates of the periodicity of atmospheric blockings over Kazakhstan in the spring-summer time according to ERA 5 reanalysis data -- Relations of interannual variability of topography of water surfaces of oceanic regions with solar activity on the example of Black and Azov seas -- Filtration of salt solutions taking into account the Osmotic effect -- Investigation of features of water circulation in the northern part of the Black Sea on the basis of the assimilation of observational data in the autumn-winter season of 2016 -- Propagation of tsunami waves in a T-shaped bay -- The Features of Simulation of Radar Altimeter Return Waveform Using Hermite Polynomials -- Abnormal Statistics of Sea Waves -- Emission of nanoparticles during loading rock salt -- Retrospective analysis methods in the study of the existence of anomalous processes in geodynamic systems.
    Abstract: The book presents short papers of participants of the 8th International Scientific Conference-School for Young Scientists "Physical and Mathematical Modeling of Earth and Environment Processes" (Ishlinsky Institute for Problems in Mechanics of the Russian Academy of Sciences). The book includes theoretical and experimental studies of processes in the atmosphere, oceans, the lithosphere and their interaction; environmental issues; problems of human impact on the environment; methods of geophysical research.
    Type of Medium: Online Resource
    Pages: X, 646 p. 277 illus., 180 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031259623
    Series Statement: Springer Proceedings in Earth and Environmental Sciences,
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Underground construction. ; Geotechnical Engineering and Applied Earth Sciences. ; Underground Engineering and Tunnel Construction.
    Description / Table of Contents: Introduction,- TBM Principle and Structure -- TBM Selection and Adaptability Design -- TBM Cutterhead and Cutter Design -- TBM Construction Organization -- TBM Assembling and Tunneling -- TBM Construction in Special Stratum -- Cutter Management in TBM Construction -- TBM Maintenance and Disassembling -- Risk Control in TBM Construction -- TBM Design and Construction Example. .
    Abstract: This book comprehensively covers the latest technology of TBM's structure and working principle, selection and adaptability design, cutter head design, construction organization and risk control and discusses typical domestic and global case studies on different periods of major TBM projects. Through detailed data and accurate charts, it offers operational guidance with high empirical value. This book is suitable for design, manufacturing, project management, construction and civil and mechanical engineering in the field of TBM technology.
    Type of Medium: Online Resource
    Pages: XXIII, 854 p. 474 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819900596
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Water. ; Hydrology. ; Refuse and refuse disposal. ; Sedimentology. ; Geotechnical Engineering and Applied Earth Sciences. ; Water. ; Waste Management/Waste Technology. ; Sedimentology.
    Description / Table of Contents: 1. Introduction -- 2. Study on stratigraphic sedimentary characteristics and sedimentary water control mechanism in Yushen mining area -- 3. Characteristics of eco geological environment zoning in ecologically fragile mining areas -- 4. Classification and characteristic analysis of roof water disaster in Yushen mining area -- 5. Study on deformation and damage law of coal seam mining intensity on overlying water bearing (impermeable) rock layer -- 6. Study on the impact of coal mining on surface ecology and groundwater flow field -- 7. Mechanism and prevention and control technology of water inrush caused by mining deterioration in extremely thick sandstone weakly cemented aquifer -- 8. Mechanism and prevention technology of water inrush and sand break under the condition of strong mining with thick loose pores in thin bedrock -- 9. Study on the construction and development of "coal water" dual resource mine under the threat of roof water disaster -- 10. Conclusion.
    Abstract: This book targets to earth scientists and engineers, in particular students, researchers, managers, and practitioners, who are interested in mining engineering, environmental engineering, green coal mining, sustainable water resource management, and effective measures to balance mine safety and ecological conservation. In the disciplines of mine hydrogeology and mining engineering, there have always been difficulties in the theoretical interpretation of the changes in the physical and hydraulic characteristics of water resisting strata during coal seam mining. In the past 10 years, the authors studied the relevant contents by using the methods of physical simulation, numerical simulation, field test and mining practice of similar materials, so as to understand the internal relationship between the stratigraphic sedimentary characteristics of the mining area and the occurrence mechanism of mine water disaster. On the premise of analyzing and studying the stratigraphic sedimentary environment in the mining area in detail, it is of great significance for the realization of "coal water" dual resource mining in the mining area to divide the types of roof water disaster in the mining area and study the formation mechanism of mine water disaster caused by different rock formation combinations and mining methods.
    Type of Medium: Online Resource
    Pages: XVI, 360 p. 222 illus., 194 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031331404
    Series Statement: Professional Practice in Earth Sciences,
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Engineering geology. ; Natural disasters. ; Geotechnical Engineering and Applied Earth Sciences. ; Geoengineering. ; Natural Hazards.
    Description / Table of Contents: Conceptual analysis of the processes of geospatial management of the development of complex systems -- Methodological bases of development management complex systems -- Methodological apparatus for providing geoinformational management of the development of complex systems -- Geoinformation systems of development management complex systems -- Risk management in management decision making development of complex systems.
    Abstract: The monograph presents the results of the development of the theoretical foundations of geoinformation management of the development of distributed organizational and technical systems and territories. The objectives of the research identified the main tasks to be solved: 1) conceptual analysis of the processes of geoinformation management of the development of spatially distributed natural and technical systems. 2) methodological foundations for managing the development of natural and technical systems. 3) methodological apparatus for providing geoinformation management for the development of natural and technical systems. 4) geoinformation systems for managing the development of natural and technical systems. 5) methods and models of decision-making risk management in managing the development of natural and technical systems. The results obtained allow, at subsequent stages of research, to develop decision-making methods based on geoinformation for real control systems of various levels and purposes, practical recommendations for improving geoinformation risk management for the development of territories and organizational and technical systems, as well as methods for measuring the parameters of distributed systems, territories and water areas.
    Type of Medium: Online Resource
    Pages: VII, 413 p. 39 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031331664
    Series Statement: Earth and Environmental Sciences Library,
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Engineering geology. ; Rock mechanics. ; Soil mechanics. ; Building construction. ; Environmental engineering. ; Civil engineering. ; Foundations. ; Geotechnical Engineering and Applied Earth Sciences. ; Geoengineering. ; Soil and Rock Mechanics. ; Solid Construction. ; Environmental Civil Engineering. ; Foundation Engineering.
    Description / Table of Contents: Introduction -- Observation Methods and Geotechnical Issues -- Types of Instrumentation -- Planning Geotechnical Instrumentation Projects -- Geotechnical Instrument Installation -- Monitoring, Data Verification, and Presentation -- Analyses and Performance Assessment -- Factors Affecting Measured Instrument Data -- Case Studies.
    Abstract: Geotechnical Instrumentation and Applications explains the geotechnical issues encountered in the implementation of construction projects dealing with ground, groundwater, and earth infrastructures, including land reclamations, dams, embankments, landfill construction, excavations, and tunnelling. The book describes the types of geotechnical instrumentation available in the market and walks readers through the geotechnical issues usually encountered in construction projects and observational methods applying geotechnical instruments, planning, and implementation of geotechnical instrumentation projects. Detailed coverage of the calibration and installation process of geotechnical instruments, the verification of measured data, and the recording and documentation of as-built drawings of geotechnical instruments installed are presented. Coverage also includes methods of measurement, recommended monitoring frequencies for manual monitoring and methods of data processing and presentation, as well as analyses and interpretations of monitored data for performance assessment. Factors affecting measured instrument data are also discussed with a few examples. Case studies are presented with field data collected during the implementation of large-scale ground improvements and ground engineering projects involving extensive geotechnical instrumentation works. The book will be an ideal text for upper-undergraduate and graduate geotechnical engineering, foundation engineering, and soil mechanics courses and a hands-on reference for practitioners who apply geotechnical instrumentation in the construction industry. Written by experienced practicing engineers; Discusses geotechnical issues in ground, groundwater, and earth infrastructures; Includes numerous case studies on the application of geotechnical instrumentation and observational methods.
    Type of Medium: Online Resource
    Pages: XIX, 355 p. 284 illus., 185 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031342752
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Technological innovations. ; Engineering geology. ; Geophysics. ; Geotechnical Engineering and Applied Earth Sciences. ; Innovation and Technology Management. ; Geoengineering. ; Geophysics.
    Description / Table of Contents: Chapter 1. Engineering Management Ontology -- Chapter 2. Engineering Management Epistemology -- Chapter 3. Engineering Management Methodology -- Chapter 4. Engineering Management Decision Theory -- Chapter 5. Engineering Management Organization Theory -- Chapter 6. Engineering Management Value Theory -- Chapter 7. Engineering Management Innovation Theory -- Chapter 8. Engineering Management Environment Theory -- Chapter 9. Engineering Management Humanities -- Chapter 10. Engineering Management Theory -- Index.
    Abstract: This book presents a comprehensive overview of engineering management, giving readers a complete picture of this research field. Following an introduction, the book explores: • Engineering Management Ontology • Engineering Management Epistemology • Engineering Management Methodology • Engineering Management Decision Theory • Engineering Management Organization Theory • Engineering Management Value Theory • Engineering Management Innovation Theory • Engineering Management Environment Theory • Engineering Management Humanities • Engineering Management Ethics Theory The book includes case studies that demonstrate how various concepts can be practically applied to resolve real-world problems. The book is a valuable read for professionals of engineering management, management and systems engineering.
    Type of Medium: Online Resource
    Pages: X, 566 p. 53 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819911684
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Engineering geology. ; Refuse and refuse disposal. ; Geotechnical Engineering and Applied Earth Sciences. ; Geoengineering. ; Waste Management/Waste Technology.
    Description / Table of Contents: Chapter 1 Introduction -- Part 1 Fundamentals -- Chapter 2 Shear behavior and damage characteristics of rock fracture -- Chapter 3 Water-rock interaction in rock fracture -- Chapter 4 Thermal effects on rock mechanical and hydraulic behaviors -- Part 2 Numerical methods -- Chapter 5 Governing equations for coupled THMC processes in fractured rocks -- Chapter 6 Numerical Modeling on coupled THMC processes in fractured rocks -- Chapter 7 Equivalent flow channels in fractured rocks.
    Abstract: This book presents the coupled Thermo-Hydro-Mechanical-Chemical (THMC) processes in fractured rocks at varying scales from single fractures to fracture networks. It also discussed the implication and potential application of the advanced understanding of coupled THMC processes in fractured rocks for geotechnical and geo-energy engineering.
    Type of Medium: Online Resource
    Pages: XI, 267 p. 143 illus., 135 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819962105
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Geology. ; Water. ; Hydrology. ; Environmental monitoring. ; Geotechnical Engineering and Applied Earth Sciences. ; Geology. ; Water. ; Environmental Monitoring.
    Description / Table of Contents: Introduction to “Groundwater in Arid and Semi-arid Areas” -- Groundwater in Arid and Semi-Arid Regions of India: A Review on the Quality, Management and Challenges -- Vulnerability to Pollution of Karstic Aquifers in the Tafna River Basin and Risk Mitigation Strategies (Northwest Algeria) -- Effect of Urbanization on Water Resources: Challenges and Prospects -- Understanding the Challenges: Sustainable Usage of Groundwater Resources in Türkiye -- Application of Geospatial Multicriteria Decision Analysis in the evaluation of groundwater Quality for Irrigation in the Northern sector of Gabes region (SE Tunisia) -- Creation of Rational Groundwater Management Schemes in the Chu Valley of the Kyrgyz Republic Based on Groundwater Modelling -- Applications of Machine Learning Models for Solving Complex Groundwater Modelling, Monitoring and Management Problems -- New Trends in Groundwater Contaminant Transport Modelling -- Groundwater Environment and Management in Kabul, Afghanistan -- Groundwater in the Nile Delta Aquifer, Egypt: Assessment, Modelling and Management with Climate Change in the Core -- Groundwater Contamination by Fluoride and Mitigation Measures for Sustainable Management of Groundwater in the Indo-Gangetic Plains of India -- Groundwater Quality in Shallow Aquifers of the Sedimentary Plain in Iraq: A Potential Concern for Drinking and Irrigation -- Investigating and Improving Natural Treatment Processes by Riverbank 2 Filtration in Egypt.
    Abstract: This book provides comprehensive studies from Middle East, African countries and Asia including Afghanistan, Algeria, Egypt, India, Iraq, Kyrgyzstan, Tunisia and Turkey on groundwater management, modelling and monitoring. A broad approach such as modelling, artificial intelligence, machine learning, and statistical models was applied in arid and semi-arid areas for management of the groundwater. These new approaches are currently in high demand. The book delves into the applications of these methods and will be a potential asset to the researchers worldwide. The book is a timely publication containing chapters based on primary data or/and extensive review chapters comprising new emerging techniques. Current high-demand research on management through the application of modelling, artificial intelligence and machine learning is the main selling point of this book.
    Type of Medium: Online Resource
    Pages: VIII, 368 p. 95 illus., 87 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031433481
    Series Statement: Earth and Environmental Sciences Library,
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Engineering geology. ; Geographic information systems. ; Natural disasters. ; Geotechnical Engineering and Applied Earth Sciences. ; Geoengineering. ; Geographical Information System. ; Natural Hazards.
    Description / Table of Contents: Section 1: Geo-Informatics and Remote Sensing -- Section 1.1: Remote Sensing Tools and Applications -- Section 1.2: Urban Remote Sensing Applications -- Section 1.3: Geospatial Information Systems (GIS), Tools and Applications -- Section 1.4: Land use applications -- Section 1.5: Natural Hazard modelling and risk assessment -- Section 1.5: Natural Hazard modelling and risk assessment -- Section 1.6: Machine learning approaches -- Section 2: Geological Engineering and Geotechnical Engineering -- Section 2.1: Soil and rock mechanics -- Section 2.2: Engineering geology -- Section 2.3: Geo-environmental engineering.
    Abstract: This book contains the best papers accepted for presentation at the 3rd Springer Conference of the Arabian Journal of Geosciences (CAJG-3). The book is divided into three parts to distinguish research studies from the fields of (1) geological and geotechnical engineering, (2) geomechanical studies based on numerical and analytical methods, and (3) geo-informatics and remote sensing. The content of these papers provides new scientific knowledge for further understanding on landslides, new stabilization techniques, importance of geophysics for engineering geology investigations as well as new empirical approaches for easily predicting some physical and hydrogeomechanical properties of geomaterials. It also sheds the light on usage of different remote sensing technologies, mapping techniques in a geographic information systems environment along with some advanced signal processing, and deep learning approaches. The book is of interest to all researchers, practitioners, and students in the fields of geological and mining engineering, geotechnical engineering, hydrogeomechanics, engineering geology, geotechnologies, groundwater and natural hazards, and analyses of some emerging earth processes and environmental variabilities.
    Type of Medium: Online Resource
    Pages: XXVIII, 240 p. 180 illus., 160 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031437595
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Water. ; Hydrology. ; Pollution. ; Engineering geology. ; Geotechnical Engineering and Applied Earth Sciences. ; Water. ; Pollution. ; Geoengineering.
    Description / Table of Contents: Evolution of vegetation and forests with future expectations of changes in Lakhdar Sub-basin -- Hydraulic study of fan spillway using Computational fluid dynamics (CFD) and experimental approaches -- Accumulation of Potentially Hazardous Elements in Water of A Significant Reservoir in Marmara Region of Türkiye -- Quality Assessment in Terms of Agricultural Water Supply and Macro Element Contents in Water of Çorlu Stream (Thrace Region, Türkiye) -- Evolution of vegetation and forests with future expectations of changes in Lakhdar Sub-basin -- Analysis of wind energy production in five cities in the southern region of Morocco -- Assessing Organic Matter of Port Dredged Sediment for Valorization in Civil Engineering -- Unveiling the Physicochemical Characteristics of Organic Materials for Composting: Unleashing Their Potential for Sustainable Waste Management in Morocco.
    Abstract: The industrial acceleration intensifies the negative environmental impacts, mainly in some very sensitive geographical areas. Environmental problems like water stress, deadly floods, scarcity of building materials, and prolonged periods of drought affect southern countries, including African nations. This book comprises the peer-reviewed proceedings of the fourth scientific conference on geosciences and environmental management (GeoME'4), held in Salé, Morocco, on June 22–24, 2023. The book interests all researchers, practitioners, and students in geosciences, the environment, and water management. The book delivers a comprehensive overview of the latest research covering the following aspects of green technologies for sustainable water and wastewater management: nature-based solutions in the water cycle and advanced technologies in geosciences, geotechnics, and the environment. Additionally, it features six keynote speakers by international experts, providing valuable insights and further enhancing its value as a comprehensive resource on the following topics: Water management Environmental engineering Geosciences and geotechnical engineering.
    Type of Medium: Online Resource
    Pages: IX, 482 p. 256 illus., 217 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031493454
    Series Statement: Springer Proceedings in Earth and Environmental Sciences,
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Engineering geology. ; Geochemistry. ; Geotechnical Engineering and Applied Earth Sciences. ; Geoengineering. ; Geochemistry.
    Description / Table of Contents: Chapter 1: Characterization of soils used in earthen building materials -- Chapter 2: Role of soil suction in the engineering behavior of earthen building materials -- Chapter 3: Stabilizers for earthen building materials -- Chapter 4: Characteristics of cement stabilized and cement +wood ash stabilized compressed earth blocks -- Chapter 5: Stabilization of adobes by plant fibers -- Chapter 6: Stabilization of adobes by cow dung particles -- Chapter 7: General conclusions.
    Abstract: Increased environmental and energy concerns have renewed global interest in raw earth as a building material. Low-energy requirements, low-cost, high availability at construction sites, and favorable engineering properties make (EBMs) an attractive alternative to conventional cement-based construction materials. Though the use of native binders to improve soil properties has garnered attention in recent literature, the available knowledge has not been covered in a single document. This book highlights the key soil properties that determine the mechanical performance of earthen building materials, importance of unsaturated soil mechanics in the engineering behavior of earthen building materials, the different types of stabilizers used to improve the engineering performance of earthen building materials including the use of select native binders, the characteristics of compressed earth blocks stabilized with cement and cement + wood ash additives and the improvement in the engineering properties of adobes stabilized with plant fibers and cow dung. .
    Type of Medium: Online Resource
    Pages: XIX, 223 p. 129 illus., 119 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031489877
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Statistics . ; Geophysics. ; Geotechnical Engineering and Applied Earth Sciences. ; Applied Statistics. ; Geophysics.
    Description / Table of Contents: A Geostatistical Heterogeneity Metric For Spatial Feature Engineering -- Iterative Gaussianisation For Multivariate Transformation -- Comparing And Detecting Stationarity And Dataset Shift -- Simulation Of Stationary Gaussian Random Fields With A Gneiting Spatio-Temporal Covariance -- Spectral Simulation Of Gaussian Vector Random Fields On The Sphere -- Geometric And Geostatistical Modeling Of Point Bars -- Application Of Reinforcement Learning For Well Location Optimization -- Compression-Based Modelling Honouring Facies Connectivity In Diverse Geological Systems -- Spatial Uncertainty In Pore Pressure Models At The Brazilian Continental Margin -- The Suitability Of Different Training Images For Producing Low Connectivity, High Net:Gross Pixel-Based Mps Models -- Probabilistic Integration Of Geomechanical And Geostatistical Inferences For Mapping Natural Fracture Networks.
    Abstract: This open access book provides state-of-the-art theory and application in geostatistics. Geostatistics Toronto 2021 includes 28 short abstracts, 18 extended abstracts, and 7 full articles in the fields of geostatistical theory, multi-point statistics, earth sciences, mining, optimal drilling, domains, seismic, classification uncertainty risk, and artificial intelligence and machine learning. All contributions were presented at the 11th International Geostatistics Congress held in virtually at Toronto, Canada, from July 12-16, 2021. This book is valuable to researchers, scientists, and practitioners in geology, mining, petroleum, geometallurgy, mathematics, and statistics.
    Type of Medium: Online Resource
    Pages: XVII, 281 p. 146 illus., 129 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031198458
    Series Statement: Springer Proceedings in Earth and Environmental Sciences,
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Energy policy. ; Energy and state. ; Environmental management. ; Geotechnical Engineering and Applied Earth Sciences. ; Energy Policy, Economics and Management. ; Environmental Management.
    Description / Table of Contents: Assessment of the Relationship between the Current Economic Development State and Environmental Pollution in the Republic of Buryatia, Russia -- New Guidelines and Risks for Asian Russia in the Implementation of the “One Belt – One Road” Project Under Current Geopolitical and Global Climate Changes -- Placer Gold Mining in the Zabaikalskii Krai and its Role in the Development of Municipal Districts -- Ecological and Economic Assessment of the Use of Wood Fuel for Heat Supply Purposes -- Demographic potential of agglomerations of Siberia: influence of the factor of population density -- Landscape-ecological zoning of a territory as the basis for identifying lands of the ecological framework of an administrative district.
    Abstract: This book highlights the environmental issues, an assessment of environmental risks within the borders of Northeast Asia and neighboring territories. This book pays special attention to the transboundary factor as the main factor in international and interregional cooperation. This book develops methods of complex, thematic, interpretative mapping, geoinformation modeling, processing of remote sensing data for geographical and environmental studies, models for the analysis of spatial and temporal geographic data, and their long series. The book is planned to widely cover economic, physical–geographical and environmental studies, including the analysis of natural resources from the state of the natural environment and resource potential to its change under the influence of various factors. .
    Type of Medium: Online Resource
    Pages: VII, 196 p. 53 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031289781
    Series Statement: Springer Proceedings in Earth and Environmental Sciences,
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Earth sciences. ; Engineering geology. ; Materials. ; Water. ; Hydrology. ; Geotechnical Engineering and Applied Earth Sciences. ; Earth Sciences. ; Geoengineering. ; Materials Engineering. ; Water.
    Description / Table of Contents: The Contribution of Engineering Geosciences to the Durability of Concrete Structures -- Comparative Analysis of Clinker Manufactured in Two Cement Plants in Spain: Use of Alternative Fuels -- Sludges from the Ornamental Rock Primary Cut: Mortar Incorporation Study -- Soil Stabilisation Using 3rd Generation Polymers -- Applying Soil Thermal Regime to Improve Storage Conditions of Temperature-Sensitive Materials in Camping Tents -- Impact of the New European Standardization on Soil Laboratory Routines and Test Results: The Case of Grain Size Distribution Analysis -- Soil Particle Density Determination According to EN ISO 17892-3: 2015: Some Difficulties in Laboratory Practices -- Physical and Chemical Characterisation of Fillers for the Manufacture of Bituminous Mixtures -- Case Study of an Inert Steel Aggregate in Road Construction: Characterisation and Monitoring of the Structural Behaviour -- Review on Laboratory Testing for Hydraulically Bound Mixtures Used in Road Applications.
    Abstract: This book comprises the peer-reviewed proceedings of the 1st Conference on Georesources, Geomaterials, Geotechnologies and Geoenvironment (4GEO), Porto, Portugal, on November 7–8, 2019. The book interests all researchers, practitioners, and students in engineering geosciences, geotechnics, georesources, materials engineering, and earth and environmental sciences. Georesources, geomaterials, geotechnologies, and geoenvironment are very topical subjects and therefore deserve a deeper reflection by academia, practitioners, and society. That approach is vital to a correct sustainable resource management and an engineering design with nature within a geoethical framework. Georesources, understood as geological, hydrological and energetic resources are greatly important to society. Minerals, rocks, and water are resources that, over time, have assumed an important role in the technological development of communities. Given the increase in population and the increasing needs and intensification of their use, it is very important to ensure their sustainable management. Geomaterials are functional geological materials artificially processed for the generality of the activities developed by societies. The functional geomaterials may include rock, clay, granular materials, treated soils, and industrial waste. Geotechnologies are a very important tool for decision-making, supporting the collection, mapping, processing, and analysis of data with geographical information systems and other geo-techniques used in the most diverse fields, including to support the monitoring and prediction of geohazards. The geoenvironment is a transversal field that identifies continuous earth changes and to find solutions to the resulting socioeconomic and environmental changes. Climate change, industrialization, and anthropic activity are, among others, factors of pressure and alteration of the natural environment, so minimizing impacts and emerging hazards and risks. Main topics include: 1. Geomaterials, Geotechnics, and Georesources 2. Geotechnologies, Engineering Geosciences, and Geohazards 3. Geoenvironment, Water, and Climate Change.
    Type of Medium: Online Resource
    Pages: XXV, 291 p. 162 illus., 141 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031259869
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Mechanical engineering. ; Geotechnical Engineering and Applied Earth Sciences. ; Mechanical Engineering.
    Description / Table of Contents: 1 Introduction -- Part I Laboratory observation -- 2 Rock mechanics in hydraulic fracturing operations -- Part II Laboratory observation -- 3 Reservoir characteristics -- 4 Constant flow injection -- 5 Constant pressure injection -- Part III Theoretical modeling considering Nonuniform fluid pressure -- 6 Fracture initiation -- 7 Fracture propagation -- 8 Fracture interaction behaviors -- Part IV Field implication -- 9 Formation of complex networks -- Epilogue -- References.
    Abstract: This open access book is the first to consider the effect of non-uniform fluid pressure in hydraulic fractures. The book covers the key topics in the process of hydraulic fracture nucleation, growth, interaction and fracture network formation. Laboratory experiments and theoretical modeling are combined to elucidate the formation mechanism of complex fracture networks. This book is suitable for master’s/Ph.D. students, scientists and engineers majoring in rock mechanics and petroleum engineering who need to use a more reliable model to predict fracture behavior.
    Type of Medium: Online Resource
    Pages: XII, 268 p. 147 illus., 141 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819925407
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Geotechnical engineering. ; Geology. ; Sedimentology. ; Geophysics. ; Geotechnical Engineering and Applied Earth Sciences. ; Geology. ; Sedimentology. ; Geophysics.
    Description / Table of Contents: Chapter 1: Analysis of existing approaches to solving the problem of sand production during the operation of UGS wells -- Chapter 2: Experimental facilities for studying the deformation and strength properties of rocks and geomechanical modelling -- Chapter 3: Methodology for performing TILTS experiments to study the deformation, strength and filtration properties of rocks -- Chapter 4: Results of TILTS testing of the deformation, strength and filtration characteristics of reservoir rocks at uderground gas storage facilities based on triaxial tests -- Chapter 5: Geomechanical modelling of the stress-strain state in UGS reservoirs during cyclic changes in reservoir pressure and downhole pressure -- Chapter 6: Physical modelling programs of rock deformation and fracture in the near-wellbore zone of USG during gas injection and extraction -- Chapter 7: Results of physical modelling of deformation and filtration processes in the bottomhole zone of ugs wells during gas extraction and injection -- Chapter 8: Rationale for the possibility of using the directed unload reservoir method (DUR method) to increase rock permeability in the bottomhole zone of UGS wells -- Chapter 9: Justification of predictive recommendations for maximum and minimum allowable drawdowns, well flow rates and prevention of sand production.
    Abstract: This book is devoted to the most important and urgent problems arising during the operation of underground gas storage facilities (UGS) and associated with the destruction of the reservoir and sand production into the wells. UGS facilities play a special role in ensuring high reliability of stable and guaranteed gas supplies to consumers. However, despite many years of experience in UGS well operation, there is still no sufficiently substantiated geomechanical model of reservoir failure and a mathematical description of the processes occurring in the reservoir-well system, taking into account the peculiarities of the mechanical behavior of reservoir rocks during cyclic injection and extraction of gas. As a result, there are no reliable criteria for establishing a rational regime for the operation of an UGS wells in conditions of a possible destruction of reservoir rocks. Further development of underground gas storage direction requires the introduction of innovative technologies that can be used both in the design of new UGS facilities and to extend the safe and efficient operation of existing underground gas storage facilities. To solve these problems, the most promising technologies, taking into account their efficiency, relatively low cost and environmental safety, are those based on the geomechanical approach. The book is addressed to specialists in the development and operation of underground gas storage facilities, as well as specialists in geomechanics of oil and gas fields. It can be useful for students and graduate students studying in the speciality "Development of oil and gas fields".
    Type of Medium: Online Resource
    Pages: XIV, 147 p. 56 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031347658
    Series Statement: Springer Geology,
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Oncology. ; Immunology. ; Metastasis. ; Cytology. ; Cancer Biology. ; Oncology. ; Immunology. ; Metastasis. ; Cell Biology.
    Description / Table of Contents: Chapter 1. A Systemic View of Metastatic Disease: Inter-organ Crosstalk and Therapeutic Implications -- Part I. Systemic Regulation in Metastatic Disease -- Chapter 2. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles -- Chapter 3. Bone Metastasis: Systemic Regulation and Impact on Host -- Chapter 4. Targeting Metastatic Disease: Challenges and New Opportunities -- Part II. Cachexia: A Debilitating Systemic Effect of Cancer -- Chapter 5. Signaling Pathways That Promote Muscle Catabolism in Cachexia -- Chapter 6. The Role of Interleukin-6 Cytokines in Cancer Cachexia -- Chapter 7. NF-kB Signaling in the Macroenvironment of Cancer Cachexia -- Part III. Therapy-induced Muscle Wasting -- Chapter 8. Therapy-induced Toxicities Associated with the Onset of Cachexia -- Chapter 9. Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy -- Part IV. Preventing and Targeting Cachexia in Cancer -- Chapter 10. New Developments in Targeting Cancer Cachexia -- Chapter 11. Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer.
    Abstract: This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.
    Type of Medium: Online Resource
    Pages: VI, 203 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031095184
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Tumors Immunological aspects. ; Cancer Treatment. ; Biochemistry. ; Metabolism. ; Cell biology. ; Immunology. ; Cancer Biology. ; Cancer Microenvironment. ; Tumour Immunology. ; Cancer Therapy. ; Metabolic Pathways. ; Immunology.
    Description / Table of Contents: 1 Cancer Metabolism and Aggressive Tumor Behaviour -- 2 Immune Cell Metabolism and Function -- 3 Cancer Cell Metabolism Effecting Immune function -- 4 Immune Cell Metabolites as Fuel for Cancer Cells -- 5 Immuno-Onco metabolism and Resistance to Therapy -- 6 Targeting Immuno-Onco metaolism in Cancers -- 7 Timing of the major metabolic switches in immune cell activation and differentiation during cancer development.
    Abstract: This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.
    Type of Medium: Online Resource
    Pages: X, 218 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811662263
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Metastasis. ; Lymphatics. ; Cancer Biology. ; Metastasis. ; Lymphatic System.
    Description / Table of Contents: Section 1: Genetic and Molecular Pathways of Cancer Growth and Metastasis -- Chapter 1. Hallmarks of Cancer: Molecular Underpinnings -- Chapter 2. Unifying concept of genomic changes: The mutational landscape of cancers -- Chapter 3. Tumor Microenvironment: Coconspirator in Tumorigenesis -- Chapter 4. Hallmarks of Metastasis: Molecular Underpinnings -- Chapter 5. Hereditary Cancer Syndromes and Cancer Metastasis -- Section 2: Pathology of Cancer Growth and Metastasis -- Chapter 6. Pathologic Assessment of Lymph Node Metastasis -- Chapter 7. Pathologic Assessment of Systemic or Distant Metastasis -- Chapter 8. The Role of Angiotropic Extravascular Migratory Metastasis in Metastases -- Section 3: Dormant Cancer Cells and their Reactivation in the Host Cancer Microenvironment -- Chapter 9. Tumor Dormancy and Relapse Regulated by the Extracellular Matrix -- Chapter 10. Therapy-Induced Dormancy and Residual Disease -- Section 4: The Microenvironment of Site-Specific Metastasis - Isaac P. Witz -- Chapter 11. The Microenvironment of Site-Specific Metastasis -- Section 5: Circulating Cancer Cells and Liquid Biopsy -- Chapter 12. Circulating tumor cells and ctDNA in sarcomas -- Chapter 13. Liquid biopsy using cell-free tumor DNA for gastrointestinal cancers -- Chapter 14. Circulating tumor cells and ctDNA in prostate cancer.-Chapter 15. Circulating Tumor Cells in Lung Cancer -- Chapter 16. CTCs/ ctDNA and Brain Metastasis.-Chapter 17. Epigenetics and liquid biopsy in oncology: role in metastasis and clinical utility -- Chapter 18. Metabolic reprogramming of circulating tumor cells for metastasis -- Section 6: Lymphatic System and Cancer Metastasis -- Chapter 19. Lymphatic System Biology, Pathobiology, and Relation to Cancer Metastasis -- Chapter 20. Lymphatic Specification and Development, EMT-MET, and Cancer Spread -- Chapter 21. Lymphangiogenesis, Lymph Nodes, Cancer Lymphangiogenesis and Metastasis -- Chapter 22. Immune cell trafficking in the lymphatics, hyaluronan biology and tumour metastasis -- Chapter 23. Lymphvascular Genomics and Proteomics, Clinical Syndromes, and Cancer Metastasis -- Chapter 24. Imaging of the Lymphatic System with Relevance to Cancer and Cancer Metastasis -- Chapter 25. Lymphedema: general pathophysiology, prevention and management in invasive cancer -- Section 7: Radiological Imaging of Early Cancer and Cancer Metastases -- Chapter 26. Primary Tumor Staging and Detection of Common Sites of Distant Metastatic Disease -- Chapter 27. Imaging Modalities in the Detection and Diagnosis of Metastatic Disease -- Chapter 28. Imaging of Bone Metastases -- Chapter 29. Imaging of Lung and Soft Tissue Metastases -- Chapter 30. Image-Guided Biopsy and Intervention for Metastatic Disease -- Section 8: Sentinel Lymph Node Surgery for Solid Cancer. Chapter 31. Sentinel Lymph Node Biopsy for Primary Cutaneous Malignancy -- Chapter 32. Sentinel Lymph Node Biopsy in Breast Cancer -- Chapter 33. Sentinel node navigation surgery for upper gastrointestinal cancer -- Chapter 34. Sentinel Lymph Node Mapping in Non-Small Cell Lung, Colon, and Thyroid Carcinomas -- Section 9: Surgical Treatment of Primary and Metastatic Cancer -- Chapter 35. The efficacy and evolution of surgical management based on cancer biology -- Chapter 36. The role of surgery in managing primary and metastatic melanoma -- Chapter 37. The Role of Surgery in Managing Primary and Metastatic Breast Cancer -- Chapter 38. The role of surgery in managing primary and metastatic colorectal cancer -- Chapter 39. The Role of Surgery in Management of Gastric Cancer -- Chapter 40. The role of surgery in managing primary and metastatic hepatopancreaticobiliary cancers -- Section 10: Cancer Metastasis to the Lung -- Chapter 41. Metastatic disease of the lung -- Section 11: Cancer Metastasis to the Liver -- Chapter 42. Tumor Resection and Ablation as a Means of Controlling Hepatic Metastases -- Chapter 43. Regional Arterial Infusional Therapy as a Means of Controlling Hepatic Metastases -- Section 12: Cancer Metastasis to the Bone -- Chapter 44. Molecular Mechanisms of Metastasis to the Bone.-Chapter 45. Surgical Management of Metastatic Disease to the Upper Extremity -- Chapter 46. Surgical Management of Metastatic Disease to the Lower Extremity -- Chapter 47. Surgical management of metastatic disease to the pelvis -- Chapter 48. Surgical Management of Metastatic Disease to the Spine -- Chapter 49. Interventional radiology techniques for management of skeletal metastases -- Section 13: Cancer Metastasis to the Brain and the Nervous System -- Chapter 50. Brain Metastases: Overview and Molecular Mechanisms -- Chapter 51. Indications and Techniques for Surgical Intervention in Patients with Metastatic Brain Tumors -- Chapter 52. Brain Metastases: Current and Future pharmacological treatment -- Chapter 53. Radiotherapy for CNS Metastases -- Chapter 54. Leptomeningeal Carcinomatoses -- Section 14: Urologic Cancer and 1st Patterns of Metastasis -- Chapter 55. Urologic Cancer and 1st Patterns of Metastasis -- Section 15: Biology and Clinical Aspects of Sarcoma Progression -- Chapter 56. Soft Tissue Sarcoma -- Chapter 57. Bone Sarcoma -- Chapter 58. Liposarcoma Metastasis -- Chapter 59. Desmoid Tumors.-Chapter 60. Atypical patterns of metastases: How do Sarcoma’s metastasize? -- Chapter 61. Tumor Immune Microenvironment of Soft Tissue Sarcoma -- Section 16: The Role of Radiation in the Treatment of Primary and Metastatic Cancer -- Chapter 62. Basic Principles of Radiobiology and Cancer Metastasis Prevention -- Chapter 63. Technical Innovations in the Delivery of Radiation Therapy -- Chapter 64. Radiation Therapy in the Definitive Treatment of Cancer -- Chapter 65. Radiation Therapy for Extracranial Oligometastatic Disease -- Chapter 66. Spine Radiotherapy -- Section 17: Immunotherapy of Solid Malignancies -- Chapter 67. Immunotherapy in Melanoma and Merkel Cell Cancer -- Chapter 68. Landscape of Immunotherapy in Lung Cancer -- Chapter 69. Immuno-oncologic Treatment of Genitourinary Malignancies -- Section 18: Current Topics -- Chapter 70. Personalized Systemic Cancer Therapy -- Chapter 71. Cancer Stem Cells and Their Role in Metastasis -- Chapter 72. HPV Induced Cancers -- Chapter 73. Microbiome and Cancer Metastasis -- Chapter 74. Application of Artificial Intelligence in Research on Cancer and Its Metastasis.
    Abstract: This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. .
    Type of Medium: Online Resource
    Pages: XXIV, 806 p. 145 illus., 106 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030930844
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Tumor markers. ; Non-coding RNA. ; Cancers. ; Tumour Biomarkers. ; Non-coding RNAs.
    Description / Table of Contents: Chapter 1. The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective -- Chapter 2. Circulating MicroRNAs as Cancer Biomarkers in Liquid Biopsies -- Chapter 3. Regulation of Immune Cells by MicroRNAs and MicroRNA-Based Cancer Immunotherapy -- Chapter 4. Machine-Learning-Based Methods and Best Practices of MicroRNA-Target Prediction and Validation -- Chapter 5. Turning Data to Knowledge: Online Tools, Databases and Resources in MicroRNA Research -- Chapter 6. Bioinformatics Methods for Modeling MicroRNA Regulatory Networks in Cancer -- Chapter 7. Analysis of the p53/MicroRNA Network in Cancer -- Chapter 8. Machine Learning Using Gene-Sets to Infer miRNA Function -- Chapter 9. miRNA:miRNA Interactions: A Novel Mode of miRNA Regulation and Its Effect on Disease -- Chapter 10. ClustMMRA v2: A Scalable Computational Pipeline for the Identification of MicroRNA Clusters Acting Cooperatively on Tumor Molecular Subgroups -- Chapter 11. 3D Modeling of Non-coding RNA Interactions.
    Abstract: This book provides an update on the latest development in the field of microRNAs in cancer research with an emphasis on translational research. Since the early 2000s, microRNAs have been recognized as important and ubiquitous regulators of gene expression. Soon it became evident that their deregulation can cause human diseases including cancer. This book focuses on the emerging opportunities for the application of microRNA research in clinical practice. In this context, computer models are presented that can help to identify novel biomarkers, e.g. in circulating microRNAs, and tools that can help to design microRNA-based therapeutic interventions. Other chapters evaluate the role of microRNAs in immunotherapy, immune responses and drug resistance. Covering key topics on microRNAs in cancer research this book is a valuable resource for both emerging and established microRNA researchers who want to explore the potential of microRNAs as therapeutic targets or co-adjuvants in cancer therapies.
    Type of Medium: Online Resource
    Pages: VII, 317 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031083563
    Series Statement: Advances in Experimental Medicine and Biology, 1385
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Cytology. ; Clinical biochemistry. ; Cancer Biology. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.
    Abstract: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: X, 494 p. 40 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030997083
    Series Statement: Biology of Extracellular Matrix, 11
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Cancer Epidemiology. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Epidemiology. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Module 1_Overview of Breast Cancer -- Module 2_Cell and Molecular Biology of Breast Cancer-Diagnosis and Prognosis -- Module 3_Breast Cancer Treatment.
    Abstract: This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy. Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.
    Type of Medium: Online Resource
    Pages: XVII, 536 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811901973
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Geography. ; Earth sciences. ; Civil engineering. ; Environmental monitoring. ; Mineralogy. ; Geotechnical Engineering and Applied Earth Sciences. ; Regional Geography. ; Earth and Environmental Sciences. ; Civil Engineering. ; Environmental Monitoring. ; Mineralogy.
    Description / Table of Contents: Chapter 1. Drilling targets in the Polar Regions -- Chapter 2. Drilling challenges in the Polar Regions -- Chapter 3. Direct-push and percussion drilling -- Chapter 4. Non-coring erosion drilling in permafrost -- Chapter 5. Auger and rotary dry drilling -- Chapter 6. Rotary drilling with drilling fluid circulation -- Chapter 7. Air and foam drilling -- Chapter 8. Special drilling methods in the Polar Regions -- Chapter 9. Offshore drilling and sampling in the Polar Regions. Concluding Remarks, References.
    Abstract: This book provides a comprehensive review of drilling technologies in the polar regions, from the portable drilling equipment for shallow sampling and coring, to heavy drilling equipment for deep onshore and offshore drilling. Particular attention is given to safe drilling methods in permafrost. In recent years, interest in drilling in the polar regions has increased under the pressure of the geopolitical “rush” and the undiscovered resource potential. In addition, borehole monitoring of permafrost thermal states is urgently needed to obtain evidence of climate change. The book focuses on the latest drilling technologies but also discusses the historical development of sampling, and drilling tools and devices, over the last 60–70 years providing valuable insights into a way forward and future possibilities.
    Type of Medium: Online Resource
    Pages: XVI, 387 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031072697
    Series Statement: Springer Polar Sciences,
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Geophysics. ; Geology. ; Computer vision. ; Image processing. ; Mineralogy. ; Geotechnical Engineering and Applied Earth Sciences. ; Geophysics. ; Geology. ; Computer Vision. ; Image Processing. ; Mineralogy.
    Description / Table of Contents: 1. Introduction to South African deep-level gold and platinum mining -- 2. Scenarios -- 3. Physical properties -- 4. Overview of key geophysical technologies -- 5. Top issues and applicability guidelines -- 6. Case histories.
    Abstract: This book provides the basic know-how and guidance to effectively exploit non-destructive geophysical technologies and apply them in the underground mining environment to optimise mineral extraction and to contribute to safer mining. The effective application of these technologies can enable a better understanding of the unseen orebody and the surrounding rock mass ahead of the mining face; the potential benefits of applying in-mine geophysics is demonstrated through a selection of case studies conducted in deep-level hard rock mines in South Africa. This book also offers valuable insight and training material for students in a variety of relevant mining disciplines like geology, rock engineering, mining engineering, mine planning and mineral resource management.
    Type of Medium: Online Resource
    Pages: VI, 76 p. 53 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031094910
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Natural disasters. ; Engineering design. ; Civil engineering. ; Sustainability. ; Geotechnical Engineering and Applied Earth Sciences. ; Natural Hazards. ; Engineering Design. ; Civil Engineering. ; Sustainability.
    Abstract: This book provides a new framework for analysis of slope nonlinear stochastic seismic dynamic response based on the new theoretical tool of stochastic dynamics. The coupling effects of uncertainty of geological parameters, strong dynamic nonlinearity, and randomness of ground motion are considered in the process of the seismic dynamic stability assessment of slope. In this book, an intensity frequency non-stationary stochastic ground motion model based on time-domain stochastic process description is preliminarily established to characterize the randomness of earthquakes. The spatial distribution random field model of geotechnical parameters is established to describe the time-space variability of geotechnical parameters. Based on the basic theory of stochastic dynamics, the seismic stability performance evaluation method of slope is established. The slope seismic dynamic model test based on large complex shaking table is performed to verify and modify the proposed framework and method. This book sheds new light on the development of nonlinear seismic stochastic dynamics and seismic design of slope engineering. .
    Type of Medium: Online Resource
    Pages: XXII, 155 p. 86 illus., 79 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811696978
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Geology. ; Petrology. ; Geotechnical Engineering and Applied Earth Sciences. ; Geology. ; Petrology.
    Description / Table of Contents: Introduction -- Rock Mechanical Basics -- The Bmwi Project “Dolomitkluft” and the Study Site -- Sampling and Methodology -- Results -- Discussion -- Conclusions, Implementation and Outlook.
    Abstract: The development of the base-load capable, climate-friendly, and practically inexhaustible source of "geothermal energy" represents an important pillar of the energy supply of the future. If it were possible to expand geothermal energy production accordingly, Germany could generate 100% of its energy in a climate-neutral manner by 2050. The joint research project "Dolomitkluft," funded by the German Federal Ministry for Economic Affairs and Energy from 2016 to 2018, aims to establish a new and improved reservoir model for the Upper Jurassic carbonates of the Northern Alpine Foreland Basin for deep geothermal energy. Emerged from this project, the dissertation by Mr. Stockinger geomechanically and numerically characterizes the deep geothermal reservoir in carbonate rocks—limestones and dolomites—of the Upper Jurassic in the Northern Alpine Foreland Basin in over 4000 m depth. This book specifically addresses fracture initiation, propagation, and hydraulic conductivity around a borehole and their controlling factors such as the in situ stress, the existing discontinuity network, and the geomechanical rock properties. Mr. Stockinger has thus successfully addressed the most important aspects for the retrievability of deep geothermal energy at its point of origin—namely the (deep) borehole.
    Type of Medium: Online Resource
    Pages: XLIII, 258 p. 179 illus., 166 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030945695
    Series Statement: Springer Theses, Recognizing Outstanding Ph.D. Research,
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Geography. ; Geotechnical Engineering and Applied Earth Sciences. ; Regional Geography. ; Geography.
    Description / Table of Contents: Research on Highway Canyon Bridges in China -- Suspension Bridges -- Cable-stayed Bridges -- Arch Bridges -- Girder Bridges.
    Abstract: This book presents 108 canyon bridges that best represent the highest level of bridge construction in China and is divided into four chapters including suspension bridge, cable-stayed bridge, arch bridge and beam bridge. It introduces the definition of canyon bridge for the first time and gives an overview of each bridge's structural characteristics, design and construction techniques, as well as management and maintenance measures. Furthermore, this book provides elevation layout drawings and real view pictures. Chinese version of this book was awarded “Fan Lichu Book Prize” by Bridge and Structure Committee of China Civil Engineering Society in August 2020. It is the first book accounting of canyon bridges and appeals to a wide readership, from bridge designers and engineers to the general public who has interests to learn bridge construction in mountainous areas.
    Type of Medium: Online Resource
    Pages: XI, 218 p. 247 illus., 137 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811644313
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Geology. ; Petrology. ; Geotechnical Engineering and Applied Earth Sciences. ; Geology. ; Petrology.
    Description / Table of Contents: Petrophysics or Geomechanics: A branch of Mechanics -- Petrophysical Classification of Rocks -- Experimental Permeability Tensor for Fractured Porous Rocks -- Scaling Experimental Immiscible Flow and Geomechanics in Fractured Porous Rock -- General General Conclusions.
    Abstract: The book offers novel petrophysical methods for obtaining and characterizing physical properties of sandstone and fractured carbonate rocks. The proposed experimental petrophysical test for the determination of permeability tensor ellipses in fractured rocks at a laboratory scale is a methodology of easy application and does not require complicated equipment. Such a test can be extended with 3D digital petrophysics. The estimation of principal permeability directions is useful in the realization of immiscible or miscible displacements in the rock. This book is of interest for professionals and researchers in the field of petrophysics and oil and gas exploration. .
    Type of Medium: Online Resource
    Pages: XII, 57 p. 74 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031177385
    Series Statement: Advances in Oil and Gas Exploration & Production,
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Tumor markers. ; Cancer. ; Cancer Treatment. ; Nanomedicine. ; Tumour Biomarkers. ; Cancer Biology. ; Cancer Therapy. ; Cancer Nanotechnology.
    Description / Table of Contents: Chapter 1. Introduction to cancer biomarkers -- Chapter 2.Technologies for identification and validation of cancer biomarkers -- Chapter 3. BIOMARKERS FOR CANCER DRUG DEVELOPMENT -- Chapter 4. Clinical proteomics: diagnostics and prognostic markers of Cancer -- Chapter 5.Microbiome as cancer biomarkers -- Chapter 6. Predictive biomarkers for anticancer drugs -- Chapter 7. Biomarkers in Cancer Survival and Drug Resistance -- Chapter 8. Biomarkers in tumor recurrence and metastasis -- Chapter 9. Biomarkers for Cancer Immunotherapy -- Chapter 10. Role of Biomarkers in Personalized Medicine -- Chapter 11.Development of Novel Cancer Biomarkers for Diagnosis and Prognosis -- Chapter 12. Nanotechnology for Cancer Biomarkers.
    Abstract: This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.
    Type of Medium: Online Resource
    Pages: XII, 365 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811657597
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Biochemical markers. ; Microfluidics. ; Pharmacology. ; Cancer Treatment. ; Cancer Biology. ; Biomarkers. ; Microfluidics. ; Pharmacology. ; Cancer Therapy.
    Description / Table of Contents: Part 1. Fundamentals of Microfluidics and Biosensors -- Chapter 1. Fundamentals of Biosensors and Detection Methods -- Chapter 2. How to Get Away with Gradients -- Chapter 3. Sensors and Biosensors in Organs-on-a-chip Platforms -- Chapter 4. Current Trends in Microfluidics and Biosensors for Cancer Research Applications -- Part 2. Modelling the Tumor Microenvironment and Its Dynamic Events -- Chapter 5. The Tumor Microenvironment — an Introduction for the Development of Microfluidic Devices -- Chapter 6. Biomaterials for Mimicking and Modelling Tumor Micro-environment -- Chapter 7. Advancing Tumor Microenvironment Research by Combining Organs-on-chips and Biosensors -- Chapter 8. Microfluidic-driven Biofabrication and the Engineering of Cancer-like Microenvironments -- Chapter 9. Advances in 3d Vascularized Tumor-on-a-chip Technology -- Part 3. Cancer Detection and Diagnosis -- Chapter 10. Biosensors Advances: Contributions to Cancer Diagnostics and Treatment -- Chapter 11. Flexible Sensing Systems for Cancer Diagnostics -- Chapter 12. Coupling Micro-physiological Systems and Biosensors for Improving Cancer Biomarkers Detection -- Chapter 13. Microfluidic Biosensor-based Devices for Rapid Diagnosis and Effective Anti-cancer Therapeutic Monitoring for Breast Cancer Metastasis -- Chapter 14. Liquid Biopsies: Flowing Biomarkers -- Chapter 15. From Exosomes to Circulating Tumor Cells: Using Microfludics to Detect High Predictive Cancer Biomarkers -- Chapter 16. Microfluidics for the Isolation and Detection of Circulating Tumor Cells -- Chapter 17. Evolution in Automatized Detection of Cancer Cells: Advances in Magnetic Microcytometers -- Chapter 18. Droplet-based Microfluidic Chip Design, Fabrication and Use for Ultrahigh-throughput DNA Analysis and Quantification -- Chapter 19. Emerging Microfluidic and Biosensor Technologies for Improved Cancer Theranostics -- Part 4. Clinical Applications: Towards Personalized Medicine -- Chapter 20. Microfluidics for Cancer Biomarker Discovery, Research and Clinical Application -- Chapter 21. Methods for the Detection of Circulating Biomarkers in Cancer Patients -- Chapter 22. Advances in Microfluidics for the Implementation of Liquid Biopsy in Clinical Routine.
    Abstract: This book offers a comprehensive overview of the development and application of microfluidics and biosensors in cancer research, in particular, their applications in cancer modeling and theranostics. Over the last decades, considerable effort has been made to develop new technologies to improve the diagnosis and treatment of cancer. Microfluidics has proven to be a powerful tool for manipulating biological fluids with high precision and efficiency and has already been adopted by the pharmaceutical and biotechnology industries. With recent technological advances, particularly biosensors, microfluidic devices have increased their usefulness and importance in oncology and cancer research. The aim of this book is to bring together in a single volume all the knowledge and expertise required for the development and application of microfluidic systems and biosensors in cancer modeling and theranostics. It begins with a detailed introduction to the fundamental aspects of tumor biology, cancer biomarkers, biosensors and microfluidics. With this knowledge in mind, the following sections highlight important advances in developing and applying biosensors and microfluidic devices in cancer research at universities and in the industry. Strategies for identifying and evaluating potent disease biomarkers and developing biosensors and microfluidic devices for their detection are discussed in detail. Finally, the transfer of these technologies into the clinical environment for the diagnosis and treatment of cancer patients will be highlighted. By combining the recent advances made in the development and application of microfluidics and biosensors in cancer research in academia and clinics, this book will be useful literature for readers from a variety of backgrounds. It offers new visions of how this technology can influence daily life in hospitals and companies, improving research methodologies and the prognosis of cancer patients.
    Type of Medium: Online Resource
    Pages: XIX, 590 p. 100 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031040399
    Series Statement: Advances in Experimental Medicine and Biology, 1379
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Tumors Blood-vessels. ; Blood-vessels Growth. ; Cancer Imaging. ; Cancer Genetic aspects. ; Cancer Biology. ; Tumour Angiogenesis. ; Cancer Imaging. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Part I: Basic Background -- Chapter 1. Fighting with Cancer: A Common Man’s Dilemma -- Chapter 2. Introduction to Cell Biology and Cell Behavior in Cancer -- Chapter 3. Tumor Biology: An Introduction -- Chapter 4. Role of Angiogenesis in Tumours -- Chapter 5. Biology, Chemistry and Physics of Cancer Cell Motility and Metastasis -- Part II: Diagnostics and Theory -- Chapter 6. MRI, CT and PETSCAN: Engineer’s Perspective -- Chapter 7. Diffusion, MRI and Cancer Diagnosis: Physicist’s Outlook -- Chapter 8. Oncology: Radiation Oncologist’s View -- Chapter 9. Oncology: Biochemists’ Perspective -- Chapter 10. Oncology: Pathologist’s View -- Part III: Cancer Therapeutics -- Chapter 11. Surgical Oncology: An Overview -- Chapter 12. Medical Oncology in Cancer Treatment -- Chapter 13. Chemotherapy Effects on Immune System -- Chapter 14. Telomerase and its therapeutic implications in Cancer -- Chapter 15. Pain Management in Oncology -- Part IV: Emerging Trends in Cancer Research -- Chapter 16. New Approaches in Cancer Research: Stem-cell research, Translational Research, Immuno-therapy, and others -- Chapter 17. Cancer Cell Lines: Its Implication for Therapeutic Use -- Chapter 18. Genomics of Cancer -- Chapter 19. Chapter 19: Diabetes and Cancer -- Chapter 20. Oncology Informatics, AI, and Drug Discovery -- Chapter 21. Radiomics: Cropping More from the Images -- Part V: Epidemiology and Statistics of Cancer -- Chapter 22. Statistics in Cancer: Diagnosis, Disease Progression, Treatment Efficacy and Patient Survival Studies -- Chapter 23. Epidemiology of Cancer: Asian Perspective -- Chapter 24. Cancer Genomics and Diagnostics: Northeast Indian Scenario.
    Abstract: This book presents multiple facets of cancer biology, including cancer diagnosis, therapeutics to the latest developments in cancer informatics, and applications of artificial intelligence for improving oncologic care. The initial section of the book discusses factors contributing to the development and causes of cancer. The subsequent sections discuss the basic principle of imaging and therapeutic techniques, including MRI, CT, and positron emission tomography (PET) Scan. The book further, explores the implications of cancer chemotherapy on the immune system and emphasizes the effective management of cancer-related pain. Towards the end, it covers recent advancements in cancer treatment, including targeted therapy, immunotherapy, interventional radiotherapy, and stem cell-based therapy. Lastly, it summarizes essential strategic elements of cancer informatics for improving patient outcome.
    Type of Medium: Online Resource
    Pages: XIX, 529 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811647529
    DDC: 571.978
    Language: English
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    Keywords: Geotechnical engineering. ; Underground construction. ; Buildings Design and construction. ; Geotechnical Engineering and Applied Earth Sciences. ; Underground Engineering and Tunnel Construction. ; Building Construction and Design.
    Description / Table of Contents: 1.Summarize -- 2. Basic theory -- 3. Analysis of ground settlement caused by subway tunnel excavation -- 4. Analysis of Deformation and Stress of Buildings under Tunnel -- 5. Quantitative prediction method of building damage -- 6. Risk Management of Crossing Buildings in Tunnel Construction -- 7. Law of ground movement in foundation pit construction of adjacent tunnel buildings -- 8. Key technologies for foundation pit construction of adjacent tunnel buildings -- 9. Impact of high-rise construction on adjacent existing tunnels.
    Abstract: This book covers tunnel construction and building construction and design. It has two parts. Part one is for the engineering practice of the subway tunnel through the base of the building in typical geological conditions, to study the mechanism and law of building damage caused by stratum deformation by in-situ monitoring, numerical simulation and theoretical analysis methods. At the same time, the risk management of subway tunnel through the bottom of the building is discussed. Second part, in view of the excavation and unloading of the foundation pit and the main structure loading in the process of high-rise building construction, discusses optimization of the construction scheme, systematic evaluation of the safety of the existing tunnel and control measures combined with the engineering practice. This book provides a valuable contribution to the field of tunnel construction and design and construction of building for both the engineering experts and graduate students as well.
    Type of Medium: Online Resource
    Pages: XVI, 309 p. 304 illus., 200 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811934742
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Renewable energy sources. ; Sustainability. ; Environmental management. ; Geographic information systems. ; Climatology. ; Geotechnical Engineering and Applied Earth Sciences. ; Renewable Energy. ; Sustainability. ; Environmental Management. ; Geographical Information System. ; Climate Sciences.
    Description / Table of Contents: Time is running out -- Why there is no time left -- City, Urbanization, and Energy -- City, Urbanization, and Energy -- Energy Footprints, the Intra Muros-Principle and Plus-Minus-Regions -- The Space-Resources Principle -- The Spatial-Prototype Principle -- The Principle of Closing Loops.
    Abstract: This book explains and illustrates how Indonesia as the largest and most populous country in Southeast Asia can become independent of fossil fuels by both reducing its energy needs and using renewable resources. A study presented in this work focuses on the Maluku Archipelago in eastern Indonesia with Ambon as its capital. Conventional energy is brought to the islands over long distances by partly simple means as boats, ships and aircrafts. This unsustainable situation calls for a decentralized renewable energy supply strategy. Based on the research presented in this book, it is clear that the archipelago has the potential to become a so-called plus-minus region. Plus-minus regions are regions that produce more renewable energy than they need and capture more CO2 than they emit. The authors are convinced that the presented strategy illustrated on the Maluku Archipelago can be transferred to other regions of the world and that only by developing plus-minus regions the international 2°C climate goal can be achieved. The model region thus serves as proof that the plus-minus target can also be achieved in emerging countries with limited financial resources. .
    Type of Medium: Online Resource
    Pages: XXIX, 166 p. 64 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030935962
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Engineering geology. ; Buildings Design and construction. ; Environmental sciences Social aspects. ; Environmental management. ; Geotechnical Engineering and Applied Earth Sciences. ; Geoengineering. ; Building Construction and Design. ; Environmental Social Sciences. ; Environmental Management.
    Description / Table of Contents: 1. Introduction -- 2. Concrete Dams -- 3. Concrete Gravity Dams -- 4. Roller Compacted Concrete Dams -- 5. Embankment Dams -- 6. Earthfill Dams -- 7. Rockfill Dams -- 8. Failure of Embankment Dams -- 9. Foundation Treatment of Dams -- 10. River Diversion -- 11. Hill Slope Stabilization at Dam and Power Projects in Himalayas -- 12. Reservoir Sedimentation -- 13. Instrumentation -- 14. Construction Aspects of Dams -- 15. Dams and Environmental Issues -- 16. Dam Safety.
    Abstract: This book discusses recent developments in dam engineering, covering theoretical as well as practical aspects. The chapters provide detailed descriptions of the types, surveys and investigations, layouts, design, thermal stresses and foundation of dams. The differences between various theories/methods of analysis used in design and their practical application and limitations are clarified. The book focuses on earth fills and landfills and stresses the importance of the foundation treatment. Failure of embankment dams is discussed particularly in the planning and construction stages of the dam. The environmental impact of dams is treated with references to river diversions and reservoir sedimentation. The book is written as a reference book for professional engineers and is also suitable for post graduate courses.
    Type of Medium: Online Resource
    Pages: XXIV, 366 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030322786
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Mechanical engineering. ; Geotechnical Engineering and Applied Earth Sciences. ; Mechanical Engineering.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Strength and failure behavior of layered sandstone under uniaxial compression and Brazilian test -- Chapter 3. Strength, deformation and damage evolution behavior of red sandstone under triaxial compression -- Chapter 4. Mechanical damage characteristics of red sandstone under triaxial cyclic loading -- Chapter 5. Strength and deformation behavior of red sandstone under simple and complex loading paths -- Chapter 6. Mechanical and fracture behaviors of yellow sandstone under triaxial monotonic and cyclic loading -- Chapter 7. Triaxial strength and deformation failure behavior of coarse marble under six different loading paths -- Chapter 8. Deformation failure characteristics of crystalline marble under triaxial cyclic loading -- Chapter 9. Strength, deformation and fracture behavior of deeply-buried marble under different confining pressures -- Chapter 10. Mechanical behaviour and damage fracture mechanism of shale under Brazilian compression -- Chapter 11. Mechanical behavior and brittleness characteristics of Longmaxi formation shale under triaxial compression -- Chapter 12. Deformation and damage failure behaviour of mudstone under single-stage and multi-stage triaxial compression -- Chapter 13. Deformation, peak strength and crack damage behavior of hollow sandstone under conventional triaxial compression -- Chapter 14. Fracturing mechanism of compressed hollow-cylinder sandstone evaluated by X-ray micro-CT scanning -- Chapter 15. Fracture evolution mechanism of hollow sandstone by X-ray micro-CT observations and 3-D numerical simulations -- Chapter 16. Thermal damage and uniaxial mechanical behavior of granite after exposure to different high temperature treatments -- Chapter 17. Triaxial mechanical and permeability behavior of sandstone after exposure to different high temperature treatments -- Chapter 18. Effect of high temperature on the permeability evolution and failure response of granite under triaxial compression.
    Abstract: This book presents mainly experimental studies on the mechanical behavior and damage fracture mechanism of deep rocks including sandstone, marble, mudstone and granite, combining with several advanced technologies of X-ray micro-CT and AE monitoring. It has several unique features: 1) Investigates the influence of loading path on triaxial strength and deformation behavior of sandstone and marble; 2) Analyzes the effect of borehole size on triaxial strength and deformation behavior of hollow sandstone; 3) Explores the influence of high temperature on triaxial deformation and permeability behavior of sandstone and granite; 4) to reveal the damage fracture mechanism of deep rocks using spatial AE techniques and X-ray micro CT observations. This work will appeal to a wide readership from technicians in the field of geotechnical engineering and engineering geology to scholars carrying out research in the rock mechanics.
    Type of Medium: Online Resource
    Pages: XXIV, 501 p. 378 illus., 347 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811677397
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Buildings Design and construction. ; Geophysics. ; Geotechnical Engineering and Applied Earth Sciences. ; Building Construction and Design. ; Geophysics.
    Description / Table of Contents: Analysis of the influence of atriums in seismic performance of RC primary school buildings -- Design Approach for an Irregular Hospital Building in Bucharest -- Performance of RC Beam Column Joint with Varying Hoop Reinforcement -- Seismic behaviour of torsionally-weak buildings with and without base isolators -- Seismic response of masonry building aggregates in historic centres: observations, analyses and tests.
    Abstract: This volume contains papers of the 9th European Workshop on the Seismic Behaviour of Irregular and Complex Structures (9EWICS) held in Lisbon, Portugal, in 2020. This workshop, organized at Instituto Superior Técnico, University of Lisbon, continued the successful three-annual series of workshops started back in 1996. Its organization had the sponsorship of Working Group 8 (Seismic Behaviour of Irregular and Complex Structures) of the European Association of Earthquake Engineering. This international event provided a platform for discussion and exchange of ideas and unveiled new insights on the possibilities and challenges of irregular and complex structures under seismic actions. The topics addressed include criteria for regularity, seismic design of irregular structures, seismic assessment of irregular and complex structures, retrofit of irregular and complex structures, and soil-structure interaction for irregular and complex structures. Beyond an excellent number of interesting papers on these topics, this volume includes the papers of the two invited lectures – one devoted to irregularities in RC buildings, including perspectives in current seismic design codes, difficulties in their application and further research needs, and another one dedicated to the challenging and very up to date topic in the area of seismic response of masonry building aggregates in historical centers. This volume includes 26 contributions from authors of 11 countries, giving a complete and international view of the problem. The holds particular interest for all the community involved in the challenging task of seismic design, assessment and/or retrofit of irregular and complex structures.
    Type of Medium: Online Resource
    Pages: IX, 320 p. 215 illus., 170 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030832216
    Series Statement: Geotechnical, Geological and Earthquake Engineering, 50
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Geophysics. ; Renewable energy sources. ; Geology. ; Geotechnical Engineering and Applied Earth Sciences. ; Geophysics. ; Renewable Energy. ; Geology.
    Description / Table of Contents: Introduction to Geothermal Systems -- Geothermal Potential across Europe -- Technologies for Deep Geothermal Energy -- Risks and Barriers -- Summary and Conclusions.
    Abstract: Since nearly 50 % of Europe's energy demand is in the heating and cooling sector, it is expected that geothermal energy will play an important role in the transition to a decarbonized energy system. However, deep geothermal energy is currently harvested mainly from areas with very favorable geothermal conditions. As these areas are geographically limited, the use of geothermal energy in less favorable regions is essential for unleashing the full potential of geothermal energy, since they make up the majority of the total geothermal potential in Central Europe. Motivated by the growing interest in deep geothermal energy among, e.g., energy companies and communities, this text reviews the state of the art in deep geothermal energy with focus on direct heating in geothermally less favorable regions. It provides an overview of technologies used to generate heat from the deep underground and discusses main technical and non-technical risks associated with deep geothermal projects. The text addresses readers with an interest in geothermal energy but does not require a background in geoscience or engineering sciences. It is suitable as textbook for Geothermal Energy courses for undergraduate students from different disciplines.
    Type of Medium: Online Resource
    Pages: VIII, 92 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030968700
    Series Statement: SpringerBriefs in Earth System Sciences,
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Geotechnical Engineering and Applied Earth Sciences.
    Description / Table of Contents: Chapter 1. Non-seismic and unconventional exploration methods for oil and gas in Cuba: perspective sectors -- Chapter 2. Geological-structural mapping and favorable sectors for oil and gas in Western Cuba through non-seismic exploration methods -- Chapter 3. Identification of hydrocarbon microseepage through remote sensors in the Majaguillar - Motembo sector, Cuba -- Chapter 4. Physical-geological modeling of potential fields in the northeastern zone of the Central Basin of Cuba.
    Abstract: The so-called "Non-conventional geophysical-geochemical exploration methods" are used, in the particular case of oil and gas exploration, for the detection and mapping of active microseepage of light hydrocarbons with a vertical nature on the gas-oil accumulations. The non-seismic exploration methods used in Cuba are: Remote Sensing, Gravimetry, Aeromagnetometry, Airborne Gamma Spectrometry (AGS) and Morphometry (non-conventional, from the Digital Elevation Model 90x90m). The AGS also classifies, as a non-conventional geophysical-geochemical method, together with the Redox Complex. Besides, it is of interest to know the geological-structural framework where these microseepage occur. That is why the benefits of using these methods (excluding Redox Complex), prior to their integration with geological and seismic data, translate into a first approximation, valid for an initial understanding of geology and mapping of favourable areas of possible gas-oil interest. Finally, from the implementation of these methods (including Redox Complex), perspective sectors for oil and gas are obtained, once the integration with geology and seismic has been carried out. The book presents a brief theoretical account of the methods used and, as practical results, a set of perspective sectors of possible interest for exploration in Cuba. As a complementary result, the book also offer an evaluation of the areas that meet the petroleum-geologist premises for the presence of large accumulations of high quality oil in Cuba.
    Type of Medium: Online Resource
    Pages: XXIX, 106 p. 63 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030929756
    Series Statement: SpringerBriefs in Earth System Sciences,
    DDC: 624.151
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Engineering geology. ; Mechanics, Applied. ; Geotechnical Engineering and Applied Earth Sciences. ; Geoengineering. ; Engineering Mechanics.
    Description / Table of Contents: Area coverage method of spatial fracture curve dimensioning -- Volume coverage method for fractal dimensioning of spatial rough sections -- AI recognition algorithm and fractal reconstruction algorithm for spatial void structure -- Evaluation of multiple fractal features of nodal spacing in granite borehole cores -- Fractal modeling of the equation of motion at the gas-liquid two-phase flow interface of low-permeability coal rocks -- Fractal modeling for calculating tortuosity and permeability of low permeability salt rocks -- Fractal order modeling of long-time creep in salt rocks under TM coupling.
    Abstract: This book focuses on learning and adapting nonlinear geometry tool in rock engineering through fractal theories, hypotheses, algorithm, practical understandings, and case studies. Understanding self-similarity and self-affinity is a prerequisite to the fractal model in rock mechanics. The book aims to provide a guide for the readers seeking to understand and build nonlinear model by fractal algorithm. The book is motivated by recent rapid advances in rock engineering in China including application of fractal theory, in addition to percolation theory. It is an essential reference to the most promising innovative rock engineering. Chapters are carefully developed to cover (1) new fractal algorithms (2) five engineering cases. This authored book addresses the issue with a holistic and systematic approach that utilizes fractal theory to nonlinear behavior in rock engineering. The book is written for researchers interested in rock and geological engineering as well as organizations engaged in underground energy practices.
    Type of Medium: Online Resource
    Pages: VII, 181 p. 111 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811697166
    DDC: 624.151
    Language: English
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Bioinformatics. ; Immunology. ; Cancer Biology. ; Computational and Systems Biology. ; Immunology.
    Description / Table of Contents: 1. Introduction: Introduction of lipids, lipid metabolism and tumor immunity -- 2. ipid metabolism and lipidomics -- 3. Applications of lipidomics in tumour immunity.-4. Overview: Lipid metabolism in tumour microenvironment -- 5. Lipid metabolism in cancer cells -- 6. Lipid metabolism in tumour-associated NK -- 7. Lipid metabolism in tumour-associated macrophages -- 8. Lipid metabolism in tumour-associated MDSCs -- 9. Lipid metabolism in tumour-associated fibroblasts -- 10. Lipid metabolism in tumour-associated B cells -- 11. Lipid metabolism in tumour-infiltrating T cells -- 12. Lipid metabolism and angiogenesis -- 13. Lipid metabolism and tumor antigen-presenting -- 14. Lipid metabolism and immune checkpoints.
    Abstract: This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery. .
    Type of Medium: Online Resource
    Pages: XI, 211 p. 24 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813367852
    Series Statement: Advances in Experimental Medicine and Biology, 1316
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Biophysics. ; Cell interaction. ; Cytology. ; Cancer Microenvironment. ; Mechanobiological Cell Signaling. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 191 p. 31 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030471897
    Series Statement: Advances in Experimental Medicine and Biology, 1270
    DDC: 571.978
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Cancer. ; Genetics. ; Molecular biology. ; Cancer Biology. ; Genetics and Genomics. ; Molecular Biology.
    Description / Table of Contents: 1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies.
    Abstract: Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.
    Type of Medium: Online Resource
    Pages: XVII, 167 p. 72 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030756994
    DDC: 571.978
    Language: English
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Diseases. ; Immunology. ; Bioinformatics. ; Cancer Biology. ; Diseases. ; Immunology. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Obesity induced chronic low-level inflammation and cancers -- Chapter 2. Adipose tissue produced estrogen as risk factor for cancers -- Chapter 3. Insulin and Insulin-like growth factor-1 associated cancers.-Chapter 4. Adipokines play important role in cell proliferation and antiproliferation -- Chapter 5. mTOR and AMP-activated protein kinase in obesity and cancer -- Chapter 6. Immune response and oxidative stress in obesity induced cancer -- Chapter 7. Role of gene polymorphism in obesity and cancer -- Chapter 8. Therapeutic role of green tea in obesity and cancer -- Chapter 9. Effect of dietary phytochemicals in obesity and cancer -- Chapter 10. Resveratrol as anti-obesity and anticancer agent -- Chapter 11. EGCG as anti-obesity and anticancer agent -- Chapter 12. miRNAs as therapeutic target in obesity and cancer -- Chapter 13. In silico updates on lead identification for obesity and cancer -- Chapter 14. In vivo models for obesity and obesity related carcinogenesis -- Chapter 15. Estrogen signaling based current and potential therapies against obesity and related diseases -- Chapter 16. Autophagy at the crossroad of obesity mediated cancer progression.
    Abstract: This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry. .
    Type of Medium: Online Resource
    Pages: IX, 361 p. 38 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811618468
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Biomedical engineering. ; Biochemical markers. ; Nanomedicine. ; Cancers. ; Biomedical Engineering and Bioengineering. ; Biomarkers. ; Cancer Nanotechnology.
    Description / Table of Contents: Chapter 1. Cancer of the Skin:Type and Etiology -- Chapter 2. Therapeutic intervention in skin cancer: Future prospects -- Chapter 3. Melanin Based Classification of Skin Types and Their Susceptibility to UV-induced Cancer -- Chapter 4. The Epidemiology of Skin Cancer Worldwide -- Chapter 5. UV-R induced Vitamin D synthesis and skin cancer -- Chapter 6. The role of microbiome in the induction, diagnosis and therapy of skin cancer -- Chapter 7. Skin Cancer: Molecular Biomarker for Diagnosis, Prognosis, Prevention and Targeted Therapy -- Chapter 8. Therapeutics intervention of skin cancer in the OMICS era -- Chapter 9. Artificial intelligence in Skin Cancer: Diagnosis and Therapy -- Chapter 10. Biomedical engineering in cancer diagnosis and therapy -- Chapter 11. Skin cancer treatment with Emphasis on Nanotechnology -- Chapter 12. Non-long coding RNA and role in skin cancer diagnosis and therapy -- Chapter 13. Potential of long non-coding RNAs in the diagnosis and therapy of melanoma skin cancer.-.
    Abstract: This book highlights the molecular and cellular mechanisms involved in the initiation and progression of skin cancer. It also explains the role of the environment in skin cancer development and explores the potential of microbiome in the diagnosis, prevention and treatment of skin cancer. The book also presents potential biomarkers for early detection of skin cancer and discusses recent advances in skin cancer prevention and treatment using photodynamic therapy. Lastly, it summarizes the applications of biomedical engineering, non-coding and nanotechnology in the diagnosis and therapeutics in skin cancer. It is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, and dermatologists.
    Type of Medium: Online Resource
    Pages: VIII, 250 p. 27 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811603648
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Genetics. ; Medical genetics. ; Cancers. ; Genetics and Genomics. ; Medical Genetics. ; Cancer Biology.
    Description / Table of Contents: Chapter 1. Polymorphisms and Mutation: What is difference? -- Chapter 2. Single nucleotide polymorphisms and pharmacogenomics -- Chapter 3. Impact of MicroRNA Polymorphisms on Breast Cancer Susceptibility -- Chapter 4. From inflammation to cancer: Role of genetic polymorphisms of Inflammatory Pathway Molecules in Gastric Cancer -- Chapter 5. Colorectal Cancer and genetic polymorphism in key regulatory low penetrance genes -- Chapter 6. Role of Genetic Polymorphisms in Breast Cancer -- Chapter 7. Genetic Polymorphisms of Essential Immune Pathogenic Response Genes and Risk of Cervical Cancer -- Chapter 8. Thyroid Cancer and genetic polymorphism -- Chapter 9. SNPs of TLRs and Bladder Cancer -- Chapter 10. Role of genetic polymorphisms in Lung Cancer.
    Abstract: This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.
    Type of Medium: Online Resource
    Pages: XXI, 339 p. 48 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813366992
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Biology. ; Cancer Treatment. ; Biotechnology. ; Molecular biology. ; Physiology. ; Cancer Biology. ; Biological Sciences. ; Cancer Therapy. ; Biotechnology. ; Molecular Biology. ; Physiology.
    Description / Table of Contents: Chapter 1. Introduction to Dietary Research and Cancer -- Chapter 2. Healthy Dietary Patterns and Cancer -- Chapter 3. Frequently Asked Diet and Nutrition Related Questions by Cancer Survivors -- Chapter 4. Dietary Recommendations of Worldwide Cancer Related Organizations -- Chapter 5. Outcome of ‘Diet and Cancer’ Related Clinical Trials -- 6. Diet and Cancer Epigenetics: A Step Towards Developing Cancer Epigenetic Diet -- 7. Role of Dietary Ingredients on Expression of Oncogenic and Tumor Suppressor miRNA -- 8. Can Diet Influence Metastasis? -- 9. Impact of Dietary Interventions on Cancer Stem Cells -- 10. Interaction of Dietary Metabolites with Anti-cancer Drug Targets -- 11. Revisiting the Anticancer Drug-Food Interactions -- 12. Functional Foods, Nutraceuticals, and Dietary Supplements in Cancer Prevention -- 13. Do Antioxidants Really Help Cancer Patients? The Puzzle of Benefits and Perils -- 14. Market of Dietary Supplements: Analysis of Health Benefits and Risk in Cancer -- 15. Cancer and Fasting: Can Fasting/Calorie Restriction (CR) or Fasting Mimicking Diet (FMD) Helps Fight Cancer? Molecular Basis of Fasting Response -- 16. Do Fasting, CR, and FMD Improves the Chemotherapy Response, Reduce Off Target Toxicities and Enhance Antitumor Immunity? Illusion or Clinical Reality? -- 17. Future Prospectus of Dietary Interventions in the Integrated Management of Cancer.
    Abstract: This book reviews all important aspects of dietary research associated with cancer with the aim of shedding new light on these conditions through combined understanding of traditional and new paradigms. The book is divided into 17 chapters, the first portion reinterprets healthy diets for cancer based on up-to-date evidence from a network science perspective, examining the dietary patterns, outcome of diet related clinical trials, emerging framework of molecular mechanisms and interactions of dietary interventions and their applications in personalized diet, ground realities of benefits and regulatory frame work for functional foods, nutraceuticals and supplements in cancer prevention and upcoming future prospectus in diet-cancer research.. The later part of the book discusses recent advances in understanding of the elaborative discourse on cancer and fasting, covering, for example, calorie restriction and fasting mimicking diet. Finally, different Dietary research and approaches are considered in the context of novel intervention for cancer research. Dietary Research in Cancer will be of interest for all researchers, nutritionists, students and clinicians in the field.
    Type of Medium: Online Resource
    Pages: XX, 197 p. 57 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811660504
    DDC: 571.978
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cell death. ; Cancer Biology. ; Cell Death.
    Description / Table of Contents: Preface -- Introduction -- The intersection of anoikis resistance and fatty acid metabolism in cancer -- Anoikis resistance in melanoma -- Anoikis mediated by stress-activated MAPK signaling pathways -- Metabolic Regulation of Anoikis -- Metabolic Reprogramming contributes to Anoikis resistance in Cancer Cells -- Role of the nuclear receptors in anoikis -- The roles of anoikis in cervical cancer -- Shc and the control of small GTPase dynamics in cellular anchorage -- Anoikis and the Human Gut Epithelium in Health and Disease -- Epithelial cell extrusion: the prelude to anoikis -- Microtubule modifications and mitochondria: role in anoikis.
    Abstract: This book provides a useful resource for graduate-level cancer cell biology courses. Since the first report, in 1994, of “anoikis”—the apoptosis that occurs when cells lack appropriate contact with the extracellular matrix—over 2,100 papers have been published on this subject. This book is the first comprehensive, in-depth and up-to-date compendium on anoikis. Chapters are authored by some of the leading researchers in the field. This book provides both mechanistic and translational information regarding anoikis, in a convenient format. Mechanistically, the following topics will be addressed in detail: The role of MAP kinase signaling The role of Shc proteins as cellular anchorage sensors The role of cellular metabolism, and fatty acid metabolism in particular, and how they are affected by oncogenic transformation How epithelial cell extrusion – the prelude to anoikis—is regulated in normal and cancer cells The convergence of TGF-b and androgen receptor signaling in the regulation of anoikis This book also discusses the specialized functions and dysregulation of anoikis in the following cancer settings: Colon cancer Melanoma Cervical cancer The book serves to update i nvestigators actively working on problems in the anoikis field, in either experimental or translational settings. For investigators encountering novel biological phenomena that might relate to anoikis, it serve as an entry point to the literature that does not require an extensive background in cell adhesion signaling or apoptosis mechanisms. .
    Type of Medium: Online Resource
    Pages: VIII, 202 p. 6 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030738563
    DDC: 571.978
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Cancer Biology. ; Medical Microbiology. ; Biomedical Research. ; Human Physiology. ; Immunology.
    Description / Table of Contents: Chapter 1: The Microbiome And The Hallmarks Of Cancer -- Chapter 2: Microbiome In Human GI Cancers -- Chapter 3: The Gut Microbiome And Colorectal Cancer -- Chapter 4: Salmonella Infection In Human Cancers -- Chapter 5: Biomarkers Of Esophageal Cancers And Precancerous Lesions -- Chapter 6: Epithelial And Immune Cell Responses To Helicobacter Pylori That Shape The Gastric Tumor Microenvironment -- Chapter 7: Microbiome And Liver Cancer -- Chapter 8: THE MICROBIOME AND UROLOGIC CANCERS -- Chapter 9: Role Of Infections And Tissue Inflammation In The Pathology Of The Fallopian Tube And High-Grade Serous Ovarian Cancer -- Chapter 10: Commensal Microbes And Their Metabolites: Influence On Host Pathways In Health And Disease -- Chapter 11: Dietary And Microbiome In Cancer Prevention -- Chapter 12: Autophagy And Cancer-Current Biology And Drug Development -- Chapter 13: Mitochondrial Regulation Of Inflammation In Cancer -- Chapter 14: Modern Germ-Free Study Designs And Emerging Static Housing Technology In A Growing ‘Human Microbiome’ Market -- Chapter 15: Machine Learning In Identification Of Disease-Associated Microbiota -- Chapter 16: Mediation Analysis Of Microbiome Data And Detection Of Causality In Microbiome Studies.
    Abstract: This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.
    Type of Medium: Online Resource
    Pages: XII, 509 p. 31 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030679514
    Series Statement: Physiology in Health and Disease,
    DDC: 571.978
    Language: English
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Mathematical models. ; Mechanical engineering. ; Geotechnical Engineering and Applied Earth Sciences. ; Mathematical Modeling and Industrial Mathematics. ; Mechanical Engineering.
    Description / Table of Contents: Introduction -- The constitutive relationship of rock and soil and its influencing factors -- Numerical Modeling Methods -- Triaxial test and numerical modeling of expansive soil -- Soil triaxial test and numerical modeling -- Triaxial test and numerical modeling of clay -- Influence of stress path and stress history on the constitutive relation -- Content induction and research prospects.
    Abstract: This book adopts numerical method to model soil constitutive relationship while it abandons the traditional idea of looking for plastic potential as the only way to model. Firstly, the triaxial compression tests of expansive soil, sand and clay under different stress paths are introduced; then the elastoplastic constitutive equations of expansive soil, sand and clay under various stress paths are established by numerical modeling method; finally, the constitutive equations are embedded in the finite element program and verified by comparing the finite element calculation results of the triaxial test soil samples with the corresponding test results. The modeling obtains high accuracy.
    Type of Medium: Online Resource
    Pages: XVI, 185 p. 84 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811632310
    DDC: 624.151
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Natural disasters. ; Buildings Design and construction. ; Geotechnical Engineering and Applied Earth Sciences. ; Natural Hazards. ; Building Construction and Design.
    Description / Table of Contents: Chapter 1. Fundamentals of Seismic Structural Design -- Chapter 2. Fundamentals of Seismic Structural Analysis -- Chapter 3. Force-Based Design of EC8 -- Chapter 4. Direct Displacement-Based Design -- Chapter 5. Hybrid Force-Displacement Design -- Chapter 6. Ductility-Based Plastic Design -- Chapter 7. Energy-Based Plastic Design -- Chapter 8. Design Using Modal Damping Ratios -- Chapter 9. Design Using Modal Behavior Factors -- Chapter 10. Design Using Advanced Analysis -- Chapter 11. Direct Damage-Controlled Design -- Chapter 12. Design Using Seismic Isolation -- Chapter 13. Design Using Supplemental Dampers.
    Abstract: The book, after two introductory chapters on seismic design principles and structural seismic analysis methods, proceeds with the detailed description of seismic design methods for steel building structures. These methods include all the well-known methods, like force-based or displacement-based methods, plus some other methods developed by the present authors or other authors that have reached a level of maturity and are applicable to a large class of steel building structures. For every method, detailed practical examples and supporting references are provided in order to illustrate the methods and demonstrate their merits. As a unique feature, the present book describes not just one, as it is the case with existing books on seismic design of steel structures, but various seismic design methods including application examples worked in detail. The book is a valuable source of information, not only for MS and PhD students, but also for researchers and practicing engineers engaged with the design of steel building structures.
    Type of Medium: Online Resource
    Pages: XVIII, 508 p. 210 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030806873
    Series Statement: Geotechnical, Geological and Earthquake Engineering, 51
    DDC: 624.151
    Language: English
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  • 80
    Keywords: Geotechnical engineering. ; Construction industry Management. ; Buildings Design and construction. ; Renewable energy sources. ; Building materials. ; Geotechnical Engineering and Applied Earth Sciences. ; Construction Management. ; Building Construction and Design. ; Renewable Energy. ; Building Materials.
    Description / Table of Contents: Inventory Management and Construction Project Delivery in Nigeria -- Overview of Concrete Durability Evaluation using Electrical Resistivity -- An Assessment Tool to Measure the Lean Construction Maturity Level -- Best Management Practices in Design, Construction, and Maintenance of Mechanical Systems in Data Centers -- Building Commissioning: Do Cost Benefits Outweigh the Initial Investment for U.S. Army Corp of Engineers? -- Antecedents of Client Loyalty in the Construction Professional Services Sector: A Qualitative Study -- Reducing Our Energy Usage and Reliance to Mechanical Air Conditioning through Passive Cooling: Can It Be Done at Home Today? -- Enhancing Innovativeness in the Construction Sector: A System Dynamics Analysis -- Urban Planning in the Context of Seatropolis City through the Public-Private Partnership Scheme -- Exploring the Working Conditions of People in Construction.
    Abstract: This book gathers papers presented at the 11th International Conference on Construction in the 21st Century, held in London in 2019. Bringing together a diverse group of government agencies, academics, professionals, and students, the book addresses issues related to construction safety, innovative technologies, lean and sustainable construction, international construction, improving quality and productivity, and innovative materials in the construction industry. In addition, it highlights international collaborations between various disciplines in the areas of construction, engineering, management, and technology. The book demonstrates that, as the industry moves forward in an ever-complex global economy, multi-national collaboration is crucial, and its future growth will undoubtedly depend on international teamwork and alliances.
    Type of Medium: Online Resource
    Pages: XLII, 661 p. 192 illus., 158 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030484651
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    DDC: 624.151
    Language: English
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Engineering mathematics. ; Engineering Data processing. ; Geotechnical Engineering and Applied Earth Sciences. ; Mathematical and Computational Engineering Applications.
    Description / Table of Contents: Introduction -- Finite element algorithm for continuum damage evolution of rock considering hydro-mechanical coupling -- Finite element analysis for continuum damage evolution and wellbore stability of transversely isotropic rock considering hydro-mechanical coupling -- Finite element analysis for continuum damage evolution and inclined wellbore stability of transversely isotropic rock considering hydro-mechanical-chemical coupling. .
    Abstract: This book mainly focuses on the adaptive analysis of damage and fracture in rock, taking into account multiphysical fields coupling (thermal, hydro, mechanical, and chemical fields). This type of coupling is a crucial aspect in practical engineering for e.g. coal mining, oil and gas exploration, and civil engineering. However, understanding the influencing mechanisms and preventing the disasters resulting from damage and fracture evolution in rocks require high-precision and reliable solutions. This book proposes adaptive numerical algorithms and simulation analysis methods that offer significant advantages in terms of accuracy and reliability. It helps readers understand these innovative methods quickly and easily. The content consists of: (1) a finite element algorithm for modeling the continuum damage evolution in rocks, (2) adaptive finite element analysis for continuum damage evolution and determining the wellbore stability of transversely isotropic rock, (3) an adaptive finite element algorithm for damage detection in non-uniform Euler–Bernoulli beams with multiple cracks, using natural frequencies, (4) adaptive finite element–discrete element analysis for determining multistage hydrofracturing in naturally fractured reservoirs, (5) adaptive finite element–discrete element analysis for multistage supercritical CO2 fracturing and microseismic modeling, and (6) an adaptive finite element–discrete element–finite volume algorithm for 3D multiscale propagation of hydraulic fracture networks, taking into account hydro-mechanical coupling. Given its scope, the book offers a valuable reference guide for researchers, postgraduates and undergraduates majoring in engineering mechanics, mining engineering, geotechnical engineering, and geological engineering. .
    Type of Medium: Online Resource
    Pages: XI, 196 p. 117 illus., 88 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811571978
    DDC: 624.151
    Language: English
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Civil engineering. ; Engineering geology. ; Buildings Design and construction. ; Engineering design. ; Geotechnical Engineering and Applied Earth Sciences. ; Civil Engineering. ; Geoengineering. ; Building Construction and Design. ; Engineering Design.
    Description / Table of Contents: Introduction -- General Principles and Practices -- Field Tests of Post Grouted Concrete Piles -- Field Tests of Precast Concrete Piles -- Field Tests of Composite Piles -- Field Tests of Super-long and Large Diameter Piles -- Piles under Ultimate Loads -- Capacity and Settlement Analysis -- Conclusions and Recommendations.
    Abstract: This book provides full-scale field tests of different types of pile foundations. For the testing, it includes static load tests which consider various loading orientations, dynamic load tests, inclinometer monitoring and tests that aim to determine the load transfer mechanism of pile foundation. This book also covers the up-to-date popular topic with detailed project studies. This includes the academic investigation of post-grouting technology effect on drilled shaft piles, the research of displacement and non-displacement precast pile foundation, the study of fiber-reinforced polymer material used in the geo-technical environment such as deep excavation pit in tunneling project, and the research of super-long and large diameter pile foundations. These investigations provide essential and academic information for researchers as well as engineers in role of Civil and Geotech. Not only the different types of the piles are studied, but also the relevant theory and literatures are reviewed. In this book, the diagrams are plotted in an easy way and the explanation of the diagrams and tables are described in detail. The research methods corresponding to the practical projects are detailed as well. Hence, it is useful as a reference for the students and researchers in civil and geotechnical engineering.
    Type of Medium: Online Resource
    Pages: XXVI, 272 p. 265 illus., 110 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813361836
    Series Statement: Advanced Topics in Science and Technology in China, 62
    DDC: 624.151
    Language: English
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    Keywords: Geotechnical engineering. ; Geophysics. ; Geotechnical Engineering and Applied Earth Sciences. ; Geophysics.
    Abstract: This book is meant for geoscientists and engineers who are beginners, and introduces them to the field of seismic data interpretation and evaluation. The exquisite seismic illustrations and real case examples interspersed in the text help the readers appreciate the interpretation of seismic data in a simple way, and at the same time, emphasize the multidisciplinary, integrated practical approach to data evaluation. A concerted effort has been made for the readers to realize that mindless interpretation of seismic data using sophisticated software packages, without having a grasp on the elementary principles of geology and geophysics, and coupled with their over-reliance on workstations to provide solutions can have appalling results all too very often.
    Type of Medium: Online Resource
    Pages: XV, 304 p. 235 illus., 77 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030753016
    Series Statement: Advances in Oil and Gas Exploration & Production,
    DDC: 624.151
    Language: English
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    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Molecular genetics. ; Proteins . ; Cancer Biology. ; Molecular Genetics. ; Protein Biochemistry.
    Description / Table of Contents: Chapter 1: Overview of histone modification -- Chapter 2: The histone H3 family and its deposition pathways -- Chapter 3: Histone H3K27M Mutation in Brain Tumors -- Chapter 4: Histone Mutations and Bone Cancers -- Chapter 5: Histone H3G34 mutation in brain and bone tumors -- Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target.
    Abstract: This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.
    Type of Medium: Online Resource
    Pages: VII, 96 p. 17 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811581045
    Series Statement: Advances in Experimental Medicine and Biology, 1283
    DDC: 571.978
    Language: English
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Human physiology. ; Diseases. ; Oncology. ; Regenerative medicine. ; Cancer Biology. ; Human Physiology. ; Diseases. ; Oncology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Chapter 1. Isolation and characterization of extracellular vesicles: classical and modern approaches -- Chapter 2. Characterization and fine structure of exosomes -- Chapter 3. Extracellular vesicles mediate the embryonic-maternal paracrine communication -- Chapter 4. The interplay between oviduct-derived exosomes and cumulus-oocyte complexes -- Chapter 5. The interplay between exosomes and spermatozoa -- Chapter 6. Mesenchymal stem cell-derived exosomes and regenerative medicine -- Chapter 7. Therapeutic Potential of Mesenchymal Stem/Stromal Cell Derived-Exosomes -- Chapter 8. Exosomes in Neurodegenerative Disorders -- Chapter 9. Differential expression of exosomal microRNAs in neurodegenerative diseases -- Chapter 10. Urinary exosomes as a possible source of kidney disease biomarkers -- Chapter 11. Extracellular vesicles as potential therapeutic targets and biomarkers for liver disease -- Chapter 12. Implications of extracellular vesicles in blood protozoan parasitic diseases -- Chapter 13. Cancer cells-derived Exosomes and Metastasis -- Chapter 14. Extracellular vesicles and integrins: partners in cancer progression -- Chapter 15. Exosomes: the crucial element in the prostate cancer -- Chapter 16. Exosomal microRNAs: Potential Biomarkers for Cancer Diagnosis, Treatment Response, and Prognosis -- Chapter 17. Exosomes in drug delivery -- Chapter 18. Exosomes and Supported Lipid Layers as Advanced Naturally Derived Drug Delivery Systems.
    Abstract: This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.
    Type of Medium: Online Resource
    Pages: XII, 373 p. 34 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811565991
    DDC: 571.978
    Language: English
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  • 86
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. NMR-Based Metabolomics in Cancer Research -- 2. Capillary Electrophoresis–Mass Spectrometry for Cancer Metabolomics -- 3. Chemical Isotope Labeling LC-MS for Metabolomics -- 4. Single cell metabolomics by mass spectrometry imaging -- 5. Fatty Acid Metabolism and Cancer -- 6. Metabolomics of Gastric Cancer -- 7. HIF-1α metabolic pathways in human cancer -- 8. Regulation of glycolysis in head and neck cancer -- 9. Metabolomics of oral/head and neck cancer -- 10. Ion chromatography with mass spectrometry for metabolomic analysis -- 11. Methods of lipidomic analysis: Extraction, derivatization, separation and identification of lipids -- 12. Functional metabolomics and chemoproteomics approaches reveal novel metabolic targets for anti-cancer therapy -- 13. Metabolomics of glioma -- 14. Microbial metabolomics: From methods to translational applications -- 15. Advances in the study of N6-methyladenine in eukaryotes -- 16. NMR Based Metabolomics -- 17. Quantitative analysis of oncometabolite 2-hydroxyglutarate -- 18. Tracer-based Cancer Metabolomic Analysis -- 19. Mass spectrometry-based shotgun lipidomics for cancer research -- 20. Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry-based Metabolomics.
    Abstract: Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
    Type of Medium: Online Resource
    Pages: XV, 312 p. 80 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030516529
    Series Statement: Advances in Experimental Medicine and Biology, 1280
    DDC: 571.978
    Language: English
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  • 87
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Immunology. ; Cancer Biology. ; Immunology.
    Description / Table of Contents: 1. The role of targeted therapy in multiple myeloma -- 2. Lenalidomide -- 3. Pomalidomide -- 4. Mechanisms driving resistance to proteasome inhibitors bortezomib, carfilzomib and ixazomib in multiple myeloma -- 5. Daratumumab -- 6. Elotuzumab -- 7. Histone deacetylase inhibitors -- 8. Bone targeted therapies -- 9. New targeted therapies for multiple myeloma under clinical investigation.
    Abstract: Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.
    Type of Medium: Online Resource
    Pages: XVII, 154 p. 5 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030734404
    Series Statement: Resistance to Targeted Anti-Cancer Therapeutics, 22
    DDC: 571.978
    Language: English
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  • 88
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Notch signaling in prevention ant therapy: fighting cancer with a two-sided sword -- Transcription factor RBPJ as a molecular switch in regulating the Notch response -- Unraveling of Hidden Secrets: The tumour suppressor Lethal (2) giant discs (Lgd)/CC2D1, Notch Signaling and Cancer -- Notch and endometrial cancer -- Notch and Esophageal Squamous Cell Carcinoma -- Notch signaling and liver cancer -- Notch inHead and Neck Cancer -- Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis -- The impact of Notch signalingfor carcinogenesis and progression of non-melanoma skin cancer: lessons learned fromcancer stem cells, tumor angiogenesis, and beyond -- Notch Signaling in Thyroid Cancer -- The Relevance of Notch Signaling in Cancer Progression -- Notch Signaling and the Breast Cancer Microenvironment -- Notch pathway: a journey from notching phenotypes to cancer immunotherapy -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books -- Notch Signaling and Embryologic Development and Molecular Basis of Notch Signaling – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XVII, 228 p. 28 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030550318
    Series Statement: Advances in Experimental Medicine and Biology, 1287
    DDC: 571.978
    Language: English
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  • 89
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Microtechnology. ; Microelectromechanical systems. ; Cancer Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Microsystems and MEMS.
    Description / Table of Contents: Chapter 1. Strategies to improve oral delivery of natural anticancer molecules -- Chapter 2. Nanoparticles catalyzing enzymatic reactions: recent developments and future prospects -- Chapter 3. Biogenic silver nanoparticles: A potent therapeutic agent -- Chapter 4. Translational studies of nanofibers-based scaffold for skin and bone tissue regeneration -- Chapter 5. Functional Dendritic Coatings for Biomedical Implants -- Chapter 6. Application of nanotherapeutics for combating human protozoan parasitic infections.
    Abstract: This book illustrates the significance of nanotechnology in the delivery of anticancer and antimicrobial drugs, biomimetic technologies, tissue engineering, sensing, diagnostics, and artificial enzymes. It first briefly discusses the use of nanotechnology for the delivery of anticancer medications, and the concept and applications of catalytically active nanomaterial-based artificial enzymes for sensing and diagnostic applications. It then explores the use of silver nanoparticle-based novel antimicrobials, and comprehensively reviews the role of nanomaterials in developing biomedical implants and tissue engineering applications. Lastly, it offers a detailed description of nanotherapeutics for combating human protozoan parasitic infections. Cutting across the disciplines, this book serves as a guide for researchers and scientists in biotechnology, medical science and material science.
    Type of Medium: Online Resource
    Pages: XIV, 240 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811599200
    DDC: 571.978
    Language: English
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  • 90
    Keywords: Cancer. ; Tumor markers. ; Medical screening. ; Materials. ; Detectors. ; Cancer Biology. ; Tumour Biomarkers. ; Cancer Screening. ; Sensors and biosensors.
    Description / Table of Contents: Chapter 1. An Introduction to Cancer Biomarkers -- Chapter 2. Cervical Cancer -- Chapter 3. Potential Biomarkers for Early Diagnosis of Cervical Cancer -- Chapter 4. Methods for Screening of Cervical Cancer: State of Art -- Chapter 5. Electrochemical DNA Biosensors for Cervical Cancers -- Chapter 6. Optical DNA based Sensors for Cervical Cancers -- Chapter 7. Other Biosensors for Cervical Cancer Detection.
    Abstract: This book highlights both conventional and nanomaterials-based biosensors for the detection of cervical cancers. It describes developments in the selective and sensitive electrochemical biosensors based on DNA for the early diagnosis of cervical cancer. Further, this book covers other nano-biosensing systems such as nano-thermometry-based sensing platforms, mechanical sensing platforms encompassing piezoelectric-based sensors, electrochemical impedance spectroscopy based on PEGylated arginine functionalized magnetic nanoparticles, and field-effect transistor-based platforms for the early detection of cervical cancer. Also, it presents conventional platforms such as vibrational spectroscopy and polymerase chain reaction techniques for the diagnosis of cervical cancer. Finally, it reviews currently available biomarkers for the early diagnosis of cervical cancer and presents strategies for developing novel biomarkers based on cellular and molecular approaches. As such, this book is a comprehensive resource for researchers and clinicians working in cervical cancer diagnostics.
    Type of Medium: Online Resource
    Pages: IX, 115 p. 18 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811625862
    DDC: 571.978
    Language: English
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  • 91
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Cancer Microenvironment. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: 1. The Tumour Microenvironment and Circulating Tumour Cells: A partnership driving metastasis and glycan-based opportunities for cancer control -- 2. Dormancy in the Tumor Microenvironment -- 3. Tumor-associated tertiary lymphoid structures: A cancer biomarker and a target for next-generation immunotherapy -- 4. Studying the tumor microenvironment in zebrafish -- 5. Pre-metastatic niche formation by neutrophils in different organs -- 6. Tumor cell invasion and the tumor microenvironment: Special focus on brain tumors -- 7. The dog as a model to study the tumor microenvironment -- 8. EFFEROCYTOSIS AND THE STORY OF “FIND ME’’, ‘’EAT ME” AND “DON’T EAT ME” SIGNALING IN THE TUMOR MICRO ENVIRONMENT -- 9. Color-coded imaging of the tumor micro-environment (TME) in human patient-derived orthotopic xenograft (PDOX) mouse models -- 10. Mitochondria and the tumor microenvironment in blood cancer -- 11. Telocytes in the tumor microenvironment -- 12. Modeling the roles of astrocytes in the metastatic tumor cell microenvironment -- 13. Roles of fibroblasts in microenvironment formation associated with radiation-induced cancer -- 14. Tumor microenvironment-associated pericyte populations may impact therapeutic response in thyroid cancer -- 15. The adrenergic nerve network in cancer -- 16. Current treatment modalities targeting tumor microenvironment in castration-resistant prostate cancer -- 17.Brain metastases and tumor microenvironment -- 18. MIGRATION STIMULATING FACTOR (MSF). ITS ROLE IN THE TUMOUR -- MICROENVIRONMENT -- 19. Mechanical Signaling in the Mammary Microenvironment - from Homeostasis to Cancer -- 20. Osteopontin Signaling in Shaping Tumor Microenvironment Conducive to Malignant Progression -- 21. Progesterone receptor signaling in the breast tumor microenvironment -- 22. Progranulin/GP88, a complex and multi-faceted player of tumor growth by direct action and via the tumor microenvironmen -- 23. Sex-based differences in the tumor microenvironmet. .
    Abstract: This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 548 p. 79 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030731199
    Series Statement: Advances in Experimental Medicine and Biology, 1329
    DDC: 571.978
    Language: English
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  • 92
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Proteins . ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Protein Biochemistry. ; Internal Medicine.
    Description / Table of Contents: CCL2 in the tumor microenvironment -- CXCL3 signaling in the tumor microenvironment -- CXCL8 Signaling in the Tumor Microenvironment -- CXCL11 signaling in the tumor microenvironment -- CXCL12 signaling in the tumor microenvironment -- CXCL13 signaling in the tumor microenvironment -- CCL24 signaling in the tumor microenvironment -- CCL25 signaling in the tumor microenvironment -- CCL27 signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression, their regulation, and their roles in immune cell recruitment, as well as how they affect cancer immunity and tumorigenesis. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Chemokines – Part Bupdates us on what we know about various aspects of the tumor microenvironment, as well as apprises us on future directions in the field. This book is essential reading for advanced cell biology and cancer biology students as well as scientists seeking an update on recent developments and research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: IX, 139 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030626587
    Series Statement: Advances in Experimental Medicine and Biology, 1302
    DDC: 571.978
    Language: English
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  • 93
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. Defining breast cancer -- 2: Breast Cancer Recurrence and Survival -- 3: Synopsis of the Treatment of Breast Cancer -- 4: The Present Treatment of Hereditary Breast Cancer -- 5: Basis for the Epigenetic Treatment of Triple Negative Breast Cancer -- 6: A New Treatment Strategy foe BRCA1 Related Breast Cancer -- 7: Present Options in the Prevention of Breast Cancer -- 8: The Physiological Basis of Breast Cancer Prevention -- 9: The Present and Future of Screening in Breast Cancer Prevention -- 10: A Vision of the Future.
    Abstract: The objective of this book is to provide a critical analysis of the present prevention strategies for breast cancer, emphasizing the cost benefits and quality of life of the patient. Rooted in the present knowledge of breast cancer biology and prevention and treatment options, the book will describe the future tools that could be available to oncologists and how these new approaches may change the landscape of recurrence and survival of the disease. Special emphasis will be given to the prevention strategies counterposing the present limitations and conflicting prevention guidelines for both hereditary and preventive non-hereditary breast cancer, and propose how the implementation of new strategies based on the present knowledge could save millions of lives and be more cost efficient. The book will present a critical status of the treatment and prevention of breast cancer and detail how a quantum leap could be achieved in the field by applying present basic research knowledge to clinical application.
    Type of Medium: Online Resource
    Pages: XI, 192 p. 41 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030728151
    DDC: 571.978
    Language: English
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  • 94
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Cancer Biology. ; Biomedical Research. ; Medical Biochemistry.
    Description / Table of Contents: Part I. Introduction -- Chapter 1. Translational Research in Surgical Oncology: Introduction and My Own Experience as a Surgeon-Scientist -- Part II. Breast Cancer Biology and Cell Signaling Pathways -- Chapter 2. Phospholipase Signaling in Breast Cancer -- Chapter 3. HER2 Signaling in Breast Cancer -- Chapter 4. Ras Signaling in Breast Cancer -- Chapter 5. Epigenetic Regulation in Breast Cancer -- Chapter 6. Role of tRNAs in Breast Cancer Regulation -- Chapter 7. Fusion Genes in Breast Cancer -- Chapter 8. DNA Damage Repair Inhibitor for Breast Cancer Treatment -- Part III. Cancer Stem Cell and Tumor Heterogeneity in Breast Cancer -- Chapter 9. Breast Cancer Metastasis -- Chapter 10. Single Cell Genomics for Tumor Heterogeneity -- Chapter 11. Advances in Tumor Sampling and Sequencing in Breast Cancer and their Application in Precision Diagnostics and Therapeutics -- Chapter 12. Cancer Stem Cell in Immune Microenvironment -- Chapter 13. Theranostics for Breast Cancer Stem Cells -- Chapter 14. Patient-Derived Xenograft Models in Breast Cancer Research -- Part IV Biomarkers for Precision Medicine in Breast Cancer Patients -- Chapter 15. Proteomic Interrogation in Cancer Biomarker -- Chapter 16. Next-Generation Sequencing-Based Biomarkers in Breast Cancer -- Chapter 17. Liquid Biopsy in Breast Cancer: Circulating Tumor Cells and Circulating Tumor DNA -- Chapter 18. Current Biomarkers for Precision Medicine in Breast Cancer -- Chapter 19. The Potential Predictors in Chemotherapy Sensitivity -- Chapter 20. Hormone Resistance -- Part V. Managing High Risk Women -- Chapter 21. High-Risk Population Based on BC Risk Factors -- Chapter 22. Breast Cancer-Related Low Penetrance Genes -- Chapter 23. Rare Coding Variants Associated with Breast Cancer -- Chapter 24. Multigene Panel Testing for Hereditary Cancer and Genetic Counseling -- Chapter 25. BRCA and Breast Cancer-Related High-Penetrance Genes -- Part VI. Next Generation Clinical Research -- Chapter 26. Clinical Databases for Breast Cancer Research -- Chapter 27. Care for Breast Cancer Survivors -- Chapter 28. Considerations in Oncoplastic Surgery -- Chapter 29. Diet Before and After Breast Cancer -- Chapter 30. Current Trends in and Indications for Endoscopy-Assisted Breast Surgery for Breast Cancer -- Chapter 31. Minimal Invasive and Individualizing Management of the Axillary Nodes -- Chapter 32. Malignant Phyllodes of Breast -- Chapter 33. Next-Generation Clinical Trials and Research with Successful Collaborations -- Part VII. Epilogue -- Chapter 34. Transformation of the Patient and Society: A Patient Survivors’ Group and Breast Cancer Awareness Campaign.
    Abstract: This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
    Type of Medium: Online Resource
    Pages: IX, 630 p. 122 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813296206
    Series Statement: Advances in Experimental Medicine and Biology, 1187
    DDC: 571.978
    Language: English
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  • 95
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Metabolism. ; Cancer Treatment. ; Cancer Metabolism. ; Cancer Therapy. ; Cancer Biology.
    Description / Table of Contents: Part I. Basic Metabolism of Cancer Cells -- Glucose Metabolism in Cancer the Warburg effect and Beyond -- Glutamine Metabolism in Cancer -- The Heterogeneity of Lipid Metabolism in Cancer -- Part II. Heterogeneity of Cancer Metabolism -- The Multifaceted Glioblastoma: from Genomic Alterations to Metabolic Adaptions -- The Intricate Metabolism of Pancreatic Cancers -- The heterogeneity of breast cancer metabolism for therapy -- Non-Hodgkin Lymphoma Metabolism -- The Heterogeneity Metabolism of Renal Cell Carcinomas -- The Heterogeneity Metabolism of Liver Cancer -- Different Tumor Microenvironments Lead to Different Metabolic Phenotypes -- The Intratumoral Heterogeneity of Cancer Metabolism -- Cancer Stem Cells Metabolism -- Metabolism of Immune cells in the Tumor Microenvironment -- Part III. Relationship between Cancer Cells and Cancer-Associated Fibroblasts -- Metabolic Relationship between Cancer-Associated Fibroblasts and Cancer Cells -- Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts -- Part IV. The metabolic interplay between cancer and other diseases -- Diabetes and Cancer: the Epidemiological and Metabolic Associations -- Bridging the Metabolic Parallels between Neurological Diseases and Cancer -- Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy -- Index.
    Abstract: This open access volume will introduce recent discoveries in the field of cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, etc. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students. .
    Type of Medium: Online Resource
    Pages: XXIII, 271 p. 55 illus., 54 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030657680
    Series Statement: Advances in Experimental Medicine and Biology, 1311
    DDC: 571.978
    Language: English
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  • 96
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Tumors Immunological aspects. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Tumour Immunology. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: Interleukin-6 function and targeting in prostate cancer -- IL-7 signaling in the tumor microenvironment -- IL-10 Signaling in the Tumor Microenvironment of Epithelial Ovarian Cancer -- Targeted delivery of IL-12 adjuvants immunotherapy by oncolytic viruses -- IL-22 signaling in the tumor microenvironment -- IL-23 and the Tumor Microenvironment -- Interleukin (IL)-24: Reconfiguring the tumor microenvironment for eliciting antitumor response -- Interleukin-31, a potent pruritus-inducing cytokine and its role in inflammatory disease and in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment. Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-6, IL-7, IL-10, IL-12, IL-22, IL-23, and IL-24 signaling. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Interleukins – Part Bupdates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XII, 134 p. 23 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030556174
    Series Statement: Advances in Experimental Medicine and Biology, 1290
    DDC: 571.978
    Language: English
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  • 97
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Cancer Treatment. ; Nanomedicine. ; Immunology. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Cancer Nanotechnology. ; Immunology. ; Cancer Stem Cells.
    Description / Table of Contents: Chapter 1_Introduction and classification of natural polyphenols -- Chapter 2_Polyphenol intakes and risk of cancer: An epidemiological scenario -- Chapter 3_Polyphenols-based prevention and therapeutics in different cancers -- Chapter 4_Effect of polyphenols on signaling pathways -- Chapter 5_Role of polyphenols in modulating gene expression in different cancers -- Chapter 6_Effect of polyphenols on Inflammation and immune response in cancer -- Chapter 7_Epigenetic basis of polyphenols in cancer prevention and therapy -- Chapter 8_Polyphenols and cancer stem cells (CSCs) -- Chapter 9_Polyphenols as modulator of oxidative stress in cancer disease -- Chapter 10_Development of novel therapeutics for enhanced polyphenol delivery -- Chapter 11_Toxicological concern of different bioactive polyphenols as anticancer agents.
    Abstract: This book reviews the applications of polyphenols in cancer treatment. The initial chapter of the book classifies different polyphenols and discusses their biological and chemical properties. The subsequent chapters then explore the diverse role of polyphenols in modulating signal transduction pathways in cancer including, cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis, and metastasis. This book highlights the usefulness of polyphenol enriched seafood in modulating the anti-tumor and anti-inflammatory cytokine IFN-γ. The book also presents nanoformulation of polyphenol as a promising strategy for their enhanced bioavailability and targeted delivery. Lastly, the book examines the toxicity and safety evaluations of polyphenols as anticancer agents.
    Type of Medium: Online Resource
    Pages: XIII, 437 p. 85 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811649356
    DDC: 571.978
    Language: English
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  • 98
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    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Geotechnical engineering. ; Buildings Design and construction. ; Building materials. ; Engineering geology. ; Geotechnical Engineering and Applied Earth Sciences. ; Building Construction and Design. ; Building Materials. ; Geoengineering.
    Description / Table of Contents: Introduction -- Dimensional Stone -- Aggregates -- Portland Cement -- Lime -- Gypsum Products -- Concrete -- Mortar -- Ceramic Materials -- Metals and Alloys -- Bituminous Materials -- Geosynthetics and other Plastics -- Wood and Cork -- Construction and Demolition Waste (CDW).
    Abstract: Construction Materials is a comprehensive textbook covering all raw materials and products related to the construction processes, and not only those applied to building structures. The book is organized to help readers achieve competent knowledge about construction materials. At the beginning of the book the author offers the general concepts, definitions, and standards adopted worldwide for these materials to be used along the book. The central part of the text covers the primary construction materials required to manufacture concrete and mortars, the most relevant construction materials in the last century. Expressly, concrete and mortar are treated in detail in dedicated chapters per component. In addition, the author addresses other relevant materials in construction such as ceramic materials, metals and alloys, bituminous materials, and geosynthetic materials. Finally, since the construction industry is one of the largest single waste producing sector in the world, the last chapter outlines the main types and characteristics of construction and demolition waste (e.g. recycled aggregates). The book appeals to students but also professionals interested in construction materials and construction and civil engineering.
    Type of Medium: Online Resource
    Pages: IX, 602 p. 712 illus., 696 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030652074
    Series Statement: Springer Textbooks in Earth Sciences, Geography and Environment,
    DDC: 624.151
    Language: English
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  • 99
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Natural disasters. ; Fire prevention. ; Buildings Protection. ; Geotechnical Engineering and Applied Earth Sciences. ; Natural Hazards. ; Fire Science, Hazard Control, Building Safety.
    Description / Table of Contents: Natural Slope -- Embankment -- Cut -- Falling Rocks -- Sabo Facility -- River Levee -- Retaining Wall -- Snow Shed/Rock Shed -- Tunnel -- Pavement -- Slab -- Steel Bridge -- Concrete Bridge -- Box Culvert -- Waterworks and Sewage.
    Abstract: This book explains in an easy-to-understand manner the “check” points to keep in mind when inspecting various social infrastructure structures. It is put together in a way that not only engineers who are on the front line of maintenance and management but also engineers who are not normally involved in maintenance and management of social infrastructures as well as general public can understand the importance of social infrastructure inspection work.
    Type of Medium: Online Resource
    Pages: XIII, 141 p. 151 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811588280
    DDC: 624.151
    Language: English
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  • 100
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Geology. ; Mathematics. ; Cogeneration of electric power and heat. ; Fossil fuels. ; Geotechnical Engineering and Applied Earth Sciences. ; Geology. ; Applications of Mathematics. ; Fossil Fuel.
    Description / Table of Contents: Chapter 1 Oilfield Development Procedures -- Chapter 2 Reservoir Geology -- Chapter 3 Reservoir Development Principle -- Chapter 4 Reservoir Development Mechanism -- Chapter 5 Production Capacity of Oilfields -- Chapter 6 Oilfield Development Planning -- Chapter 7 Tracking Study on FDP Implementation -- Chapter 8 Zonal Water Injection -- Chapter 9 Adjustment of Development Plan -- Appendix A Determination of the Horizontal Length within Reservoirs -- Appendix B Trial-and-error Method Used in Horizontal Length Determination -- Appendix C Injection-production Balance Crossplot.
    Abstract: This book focuses on oilfield performance analysis and development adjustment by integrating geology, applied mathematics, and other relevant theories. Based on the abundant and detailed field test and production data from Daqing and Tarim, two major oilfields in China, the regularities, characteristics, design, and adjustment of waterflooding development of sandstone reservoirs throughout the life cycle are described. Field development theories and practices are organically combined in this book, which, embracing comprehensive, systematic, and pragmatic contents, is conducive to development technicians to quickly grasp the characteristics of waterflooding and prepare adjustment plans. It is also useful as a textbook in petroleum colleges and short training courses.
    Type of Medium: Online Resource
    Pages: XIII, 406 p. 193 illus., 163 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811603488
    DDC: 624.151
    Language: English
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