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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Water. ; Hydrology. ; Biotic communities. ; Social sciences. ; Humanities. ; Environmental management. ; Freshwater and Marine Ecology. ; Water. ; Ecosystems. ; Humanities and Social Sciences. ; Environmental Management.
    Description / Table of Contents: Part I. Introduction -- Chapter 1. Southern Baltic Coastal Systems Analysis: Questions, Conceptions and Red Threads -- Chapter 2. Coastal Ecosystems from a Social-Ecological Perspective -- Part II. Ecological Structures and Functions of the German Baltic Sea Coast -- Chapter 3. The Abiotic Background: Climatic, Hydrological and Geological Conditions of the Southern Baltic -- Chapter 4. Geological and Sedimentary Conditions -- Chapter 5. Environmental Conditions at the Coast: The Terrestrial Ecosystems -- Chapter 6. Environmental Conditions at the Coast: Shoreline Ecosystems -- Chapter 7. Ecosystem and Landscape Functions of the Coast: Recent Research Results -- Chapter 8: Benthic Habitats and Their Inhabitants -- Part III. Ecological Structures and Functions of Coastal Water and Offshore Ecosystems -- Chapter 9. Introducing the Ecological Aspects -- Chapter 10. Baltic Sea Aquatic Ecosystems in a Gradient from Land to Open Sea -- Chapter 11. Comparison of Abiotic Parameters and Dominant Primary Producers Between the Two Main Investigation Areas -- Chapter 12. Short-Term Variability, Long-Term Trends and Seasonal Aspects in the Darß-Zingst Bodden Chain -- Chapter 13. Carbon Fluxes/Food-Webs: Effect of Macrophytes on Food Web Characteristics in Coastal Lagoons -- Chapter 14. Ecological Structure in Benthic Habitats of Offshore Waters -- Chapter 15. Patterns of Bioturbation and Associated Matter Fluxes -- Chapter 16. Seasonal Aspects and Short-Term Variability of the Pelagic Offshore Ecosystems -- Chapter 17. Long-Term Trends of the Offshore Ecosystems -- Chapter 18. Nutrient and Limitation Regimes in Coastal Water Ecosystems -- Part IV. Combining the Aspects: Ecosystem Service Assessment -- Chapter 19. The Human Factor: Coastal Social-Ecological Systems -- Chapter 20. Introduction: The Concept of Ecosystem Service Assessment Applied to Coastal Systems -- Chapter 21. The Missing Links in Ecosystem Service Research -- Chapter 22. Eudaimonic Valuation of Cultural Ecosystem Services -- Chapter 23. Economic Valuation of Cultural Ecosystem Services -- Chapter 24. Spatial Ecosystem Service Assessment Across the Land-Sea-Interface -- Chapter 25. Temporal Changes in Aquatic Ecosystem Services Provision: Approach and Examples -- Chapter 26. Assessing Temporal Changes in Ecosystem Service Provisions: Conceiving Future Pathways -- Part V. Synthesis: Assessment as a Tool for Managing Coastal Ecosystems? -- Chapter 27. Applying the Integrated Approach -- Chapter 28. Mechanisms of Ecosystem Service Production: An Outcome of Ecosystem Functions and Ecological Integrity in Coastal Lagoons -- Chapter 29. Ecosystem Service Assessment in European Coastal and Marine Policies -- Chapter 30. Ecosystem Services and Sustainable Development: The Case for Strong Sustainability -- Chapter 31. Concluding Remarks.
    Abstract: This book gives an overall analysis of the current knowledge status about structures, functions, utilization for German Baltic coast ecosystems. The main focus of this book is on the aquatic area, but land/sea interactions as well as river outfalls are included as well. Characteristic for this book is the inclusion of social science aspects. Approximately one third of its extent will be about the ecosystem services. In this segment the results of the last 6 years are presented in which a comprehensive quantification of the social relevance of ecosystems was carried out covering the entire area of the German Baltic Sea. This part builds directly on the results of scientific investigations and are in relation to social ideals. The assessment will not only be economically and ethically but also the mechanisms that are used for the valorisation of the ecosystem services will be evaluated. Both sub-areas, the classic natural science part as well as the part of social science aspects, deal with the changes caused by increasing anthropogenic influence and social (including demographic) changes. This will be among others in the sense of an exemplary historical outline. The final chapter of the synthesis therefore not only presents a summary of the level of knowledge gained and a deduction of the research needs. It further contains a presentation of the application aspects resulting from the analysis of the social relevance gained from basic scientific research. The book is aimed at scientists (and students) of natural, life and social sciences, analysing functioning and structures of coastal ecosystems with regard to sustainable use and nature protection, including aspects of coastal protection. Besides, it is thought to become a reference for all levels of decision makers and stakeholders in coastal and marine management of the Baltic and North Sea region, providing also a blueprint for system analysis respecting for societal as well as biological aspects world-wide.
    Type of Medium: Online Resource
    Pages: XV, 387 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031136825
    Series Statement: Ecological Studies, Analysis and Synthesis, 246
    DDC: 577.6
    Language: English
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  • 2
    Keywords: Freshwater ecology. ; Marine ecology. ; Reproduction. ; Physiology. ; Pollution. ; Freshwater and Marine Ecology. ; Reproductive Physiology. ; Pollution.
    Description / Table of Contents: 1. Pesticide and xenobiotic metabolism in aquatic organisms -- 2. Endocrine disrupting activity of xenobiotics in aquatic animals -- 3. Water contamination through xenobiotics and their toxic effects on aquatic animals -- 4. Cypermethrin induced reproductive toxicity in zebrafish: biochemical and molecular perspective -- 5. Impact of Pesticides Application on Aquatic Environments And Biodiversity -- 6. Impact of microplastics on reproductive and physiological aspects of aquatic inhabitants -- 7. The Impact of Xenobiotics in Development & Reproduction of fresh water Fishes -- 8. Mixtures and Reproduction in Aquatic Organisms – benefits and challenges -- 9. Phytoestrogens as Endocrine-Disrupting Agents In Aquaculture -- 10. A Proteomic Approach to Studying the Effects of Xenobiotics on Aquatic Living Organisms -- 11. Role of Cytochrome P450 in xenobiotic metabolism in fishes -- 12. Pharmacokinetic-Pharmacodynamic modelling of Xenobiotics: Fate and effect in Aquatic Animals -- 13. Occurrence of xenoestrogen alkylphenols (Octylphenols and Nonylphenol), and its impact on the aquatic ecosystem -- 14. Xenobiotics' effect on fish reproduction and development -- 15. Scientometric analysis of ecotoxicological investigations of xenobiotics in aquatic animals -- 16. Toxic effects of nanomaterials on aquatic animals and their future prospective -- 17. Microplastic Contamination in Aquatic organisms: An Ecotoxicological perspective -- 18. Effect of xenobiotics and their degradation in aquatic life -- 19. Transcriptome analysis of aquatic species exposed to endocrine disruptors -- 20. Fundamentals of genotoxicity and antiparasitic drugs associated with genotoxicity in fish -- 21. Endocrine disrupting compounds (EDCs) as emerging aquatic contaminants: Emphasis on Reproduction and Development.
    Abstract: This book summarizes the latest understanding of the impact of xenobiotics on the developmental and reproductive processes of aquatic animals, particularly nektonic forms, which comprise an important group of aquatic ecosystems. Aquaculture is quickly becoming the largest contributor of fish protein for human consumption. As the aquaculture business expands, farmed fish will be exposed to more environmental toxins, necessitating the use of chemical therapeutic drugs for fish. This book brings together experts on the regulation of environmental toxins and food chemicals from around the world, as well as researchers looking into the metabolism and disposal of foreign chemicals (xenobiotics) in fish species. The impact of xenobiotics on reproductive and developmental biology of all living forms has become of prime importance at the current time. As the effect of these xenobiotics on aquatic animals is an emerging area for research and development, several groups across the world are working on these aspects, targeting different groups of fishes in both marine and freshwater ecosystems. This collective work highlights several key and updated recent aspects of different types of xenobiotics entering aquatic ecosystems, impacts of these agents on reproductive physiology, developmental biology, breeding biology, hormonal imbalance, aquatic ecology, and pollution on the aquatic ecosystem. The unique aggregation of different types of stressors to aquatic animals under a single volume will be a useful reference for readers, including scientists, teachers, students, researchers and policymakers and those involved in aquaculture and environment conservation.
    Type of Medium: Online Resource
    Pages: XXIX, 427 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819912148
    DDC: 577.6
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.
    Abstract: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).
    Type of Medium: Online Resource
    Pages: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031229039
    Series Statement: Current Cancer Research,
    DDC: 571.978
    Language: English
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  • 4
    Keywords: Freshwater ecology. ; Marine ecology. ; Invertebrates. ; Biotic communities. ; Biodiversity. ; Applied ecology. ; Water. ; Hydrology. ; Freshwater and Marine Ecology. ; Invertebrate Zoology. ; Ecosystems. ; Biodiversity. ; Applied Ecology. ; Water.
    Description / Table of Contents: Preface -- Chapter 1: Evolution of Bilateria from a Meiofauna Perspective – Miniaturization in the Focus -- Chapter 2: Meiofauna Shaping Biogeochemical Processes -- Chapter 3: Meiofauna and Biofilms – the Slimy Universe -- Chapter 4: Meiofauna Meets Microbes: Chemosynthetic Symbioses -- Chapter 5: Marine Meiofauna Diversity and Biogeography – Paradigms and challenges -- Chapter 6: Freshwater Meiofauna – a Biota with Different Rules? -- Chapter 7: Hidden Players – Meiofauna Mediates Ecosystem Effects of Anthropogenic Disturbances in the Ocean -- Chapter 8: Deep-Sea Meiofauna – a World of its Own or Deeply Connected? -- Chapter 9: Polar Meiofauna – Antipoles or Parallels? -- Chapter 10: Cave Meiofauna - Models for Ecology and Evolution -- Chapter 11: Meiofauna – Adapted to Life at the Limits -- Concluding Remarks -- Index.
    Abstract: Since research on meiobenthos was last compiled in a textbook (2008/2009), the number of theoretical and applied studies has been growing rapidly. Supported by new methods and digital evaluation, meiobenthology has developed into a wide field, with more and more researchers studying cross-disciplinary aspects. New perspectives were summarized in a booklet (2019) to draw attention to promising research directions. The present book, written by leading experts, is a compilation of new thinking, data, methods and approaches in many relevant fields of recent meiobenthos research. The topics addressed range from bacteria and biofilms to globally changing processes, from polar regions to the deep-sea and from freshwater ecosystems to the ocean. So, this book is not simply another meiobenthos textbook - it is an attempt to identify new horizons in meiobenthos research, driven by the vision of advancing knowledge and understanding of benthic ecosystems.
    Type of Medium: Online Resource
    Pages: XII, 407 p. 49 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031216220
    DDC: 577.6
    Language: English
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  • 5
    Keywords: Freshwater ecology. ; Marine ecology. ; Microbiology. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Freshwater and Marine Ecology. ; Microbiology. ; Environmental Engineering/Biotechnology.
    Description / Table of Contents: 1. Marine Biotechnology: A Frontier for the Discovery of Nutraceuticals, Energy, and Its Role in Meeting 21st Century Food Demands -- 2. Biotechnological Utilization of the Marine Environment for Food, Drugs and Energy -- 3. Grouper Hybridization: An Effective Biotechnological Tool for Food Security -- 4. The Application of Molecular Markers to Fish Breeding and Aquaculture -- 5. Aquaculture and Applications of Green Seaweeds of the Genus Caulerpa J.V. Lamouroux, 1809 -- 6. Potential and Challenges of Sea Cucumber Holothuria Scabra Mariculture in Sabah, Malaysia -- 7. Sea Cucumber (Echinodermata: Holothuroidea) Species Diversity on the West Coast of Sabah, Malaysia -- 8. Sea Cucumbers: Source of Nutritional, Medicinal, and Cosmeceutical Products -- 9. Marine Biotechnology and its Applications in Drug Discovery -- 10. Bacteriophage as Therapeutic Strategy Against Pathogenic Vibrio -- 11. Bacterial Diversity in the Marine Environment and the Cutting-edge Tools for Isolation, Identification, and Characterization of the Marine Microbiome -- 12. Biotechnological Applications of Jellyfish-Derived Products -- 13. Application of Biotechnology in White Syndrome Coral Disease Identification -- 14. The Synergy of Remote Sensing in Marine Invasion Science -- 15. The Utilization of Agro-based Wastes by Marine Phototrophic Microbes -- 16. Artificial Intelligence Methods in Marine Biotechnology.
    Abstract: This contributed volume covers the applications of marine biotechnology for food, drugs and energy production using marine resources. It introduces many aspects of marine biotechnology, including bioenergy, pharmaceutical development, food security from mariculture, pollution handling, legal issues and conflicts. Information in the book is accompanied by clear images, flow charts, quantitative and qualitative data. Marine biotechnology is essential for realizing the previously untapped potential of marine bio-resources. These resources are used to develop innovative goods and procedures that aid in the global management of food, energy, and disease management. The development of innovative tools and solutions for more sustainable marine environmental management is another important section of this title. This reference book is of interest to teachers, researchers, and climate change scientists. It serves as an additional reading material for college, undergraduate, and graduate students of marine science and aquaculture. This is also a good research guide for food and fishing industry scientists.
    Type of Medium: Online Resource
    Pages: XIII, 354 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819906246
    DDC: 577.6
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Treatment. ; Neurosciences. ; Immunotherapy. ; Cancer Biology. ; Cancer Therapy. ; Neuroscience. ; Cancer Microenvironment. ; Immunotherapy.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.
    Abstract: This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.
    Type of Medium: Online Resource
    Pages: XII, 202 p. 21 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324291
    DDC: 571.978
    Language: English
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  • 7
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Freshwater ecology. ; Marine ecology. ; Animal culture. ; Biotechnology. ; Animal biotechnology. ; Freshwater and Marine Ecology. ; Animal Science. ; Biotechnology. ; Animal Biotechnology.
    Description / Table of Contents: Chapter 1_ Recent developments in Biosensor Technology for Fisheries and Aquaculture -- Chapter 2_Application of CRISPR-Cas9 Technology in Fish -- Chapter 3_ Nano-technological applications in Aquatic Health Management -- Chapter 4_Phenotypic plasticity and transgenerational immune priming: opportunities and potential in fisheries -- Chapter 5_Heat shock proteins in stress response: a promising tool for fish health management -- Chapter 6_Immunostimulants: Boon for disease management in Aquaculture -- Chapter 7_Molecular markers and their application in fisheries and aquaculture -- Chapter 8_Applications of Electronics in Fisheries and Aquaculture -- Chapter 9_Metatranscriptomics: A tool to study the host-microbe interactions and functional profile of fish intestinal microbiota under changing environmental conditions -- Chapter 10_Bioremediation and its application in aquaculture -- Chapter 11_Application of Probiotics in Aquaculture -- Chapter 12_Identifying novel antibiotic resistance genes (ARGs): Important aspect of metagenomic research.
    Abstract: This edited book is focused on SDG 14: life below water. This book covers all aspects of fish biotechnology and health management. A detailed description is provided of CRISPR Cas9 technology application in the development of superior variety of fish with better growth, disease resistance, etc., accompanied by numerous helpful photographs and schematic diagrams. In addition, recent developments in nanotechnology and its application in fisheries production enhancement have been discussed. Further, topics includes, probiotics, immunostimulants, fish genetic markers, bioremediation, metagenomics, transgenerational immune priming, application of cell culture in fisheries and nano-biosensor application on fish disease diagnosis, pollution monitoring, etc. are provided in details. . The book is helpful for researchers, teachers, students, farmers, and entrepreneurs in utilizing the knowledge on recent advancements in different aspects of fish genetics and biotechnology for future research and aquaculture production enhancement.
    Type of Medium: Online Resource
    Pages: XVIII, 246 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819929818
    DDC: 577.6
    Language: English
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  • 8
    Keywords: Freshwater ecology. ; Marine ecology. ; Ecology . ; Biodiversity. ; Freshwater and Marine Ecology. ; Ecology. ; Biodiversity.
    Description / Table of Contents: Chapter 1_ An Introduction to the Functions and Ecosystems Services associated with aquatic macrophytes -- Chapter 2_ Factors structuring Aquatic Macrophytes -- Chapter 3_ Aquatic Macrophytes: Ecology, Function and Services in Niger Delta, Nigeria -- Chapter 4_ Environmental and Ecological Importance of Indian Aquatic Macrophytes -- Chapter 5_ Macrophytes used as complementary medicines for curing human ailments to facilitate livelihood opportunities -- Chapter 6_ Macrophytes and their role in wetland ecosystems -- Chapter 7_ Ecotoxicology of REEs in aquatic macrophytes and prospect for bioremediation of REEs -- Chapter 8_ Efficiency of Aquatic Plants for Remediation of Wastewater -- Chapter 9_ Phytoremediation of organic contaminants: An ecofriendly approach based application of aquatic macrophytes -- Chapter 10_ Remediation of heavy metals by different aquatic macrophytes -- Chapter 11_ Translocations of heavy metals in aquatic macrophytes naturally grown in the riverine ecosystem -- Chapter 12_ Enhanced Effluent Treatment and Bioelectricity Generation Using Coupled Constructed Wetland-Microbial Fuel Cell (CW-MFC) Technology: Challenges and Opportunities -- Chapter 13_ Role of microbial communities and aquatic macrophytes in constructed wetlands for tannery wastewater treatment: Challenges and opportunities -- Chapter 14_ Role of plant-bacteria association in constructed wetlands for the removal of iron (Fe) from contaminated water. .
    Abstract: This book is a comprehensive collection of information about the features, functions, and services of aquatic macrophytes. As primary producers, aquatic macrophytes form the basis of food webs, play a major role in highly productive aquatic ecosystems, and have a significant impact on ecosystem functions and services. Macrophytes are also known to strongly influence the micro-climate and biogeochemical processes occurring in the littoral zones of marine ecosystems and the sediment dynamics of freshwater systems. They also serve as highly effective carbon sinks and play an important role in carbon sequestration. This book deals with various aspects of aquatic macrophytes, including nutrient recycling, biogeochemical processes, biomass production, wetland ecosystems, water resource management, carbon sequestration, environmental clean-up, and bioenergy production. Additionally, it presents the current status of aquatic macrophytes and discusses the impact of climate change on these plants. The book also highlights the major challenges associated with harnessing the benefits provided by aquatic macrophytes as ecosystem services. The book holds value and relevance for academicians and scientists working in the related domain. Additionally, it will serve as a valuable resource for students and researchers working in the field of ecology, biogeochemistry, wetland conservation, phytoremediation, elements biomonitoring, wastewater management, bioenergy production, etc.
    Type of Medium: Online Resource
    Pages: X, 311 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819938223
    DDC: 577.6
    Language: English
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  • 9
    Keywords: Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Zoology. ; Ecology . ; Oceanography. ; Conservation biology. ; Freshwater and Marine Ecology. ; Biodiversity. ; Zoology. ; Biooceanography. ; Conservation Biology.
    Description / Table of Contents: Part I. Introduction -- Chapter 1. Insights from Cuban Coral Reefs -- Part II. History -- Chapter 2. Research History of Corals and Coral Reefs in Cuba -- Part III. Description -- Chapter 3. Physical-Geographic Characteristics of Cuban Reefs -- Chapter 4. Outline of the Geology, Geomorphology and Evolution of the Late Qua-ternary Shelf and Uplifted Marine Terraces of Cuba; Tectonic and Sea Level Control of Present Day Coral Reef Distribution -- Chapter 5. A Remote Sensing Appraisal of the Extent and Geomorphological Diversity of the Coral Reefs of Cuba -- Part IV. Biota -- Chapter 6. Macrophytes Associated with Cuban Coral Reefs -- Chapter 7. Sponges: Conspicuous Inhabitants of the Cuban Coral Reefs and Their Potential as Bioindicators of Contamination -- Chapter 8. Species List of Cuban Stony Corals: Class Anthozoa, Order Scleractinia; Class Hydrozoa, Suborders Capitata and Filifera -- Chapter 9. Octocoral Forests: Distribution, Abundance, and Species Richness in Cuban Coral Reefs -- Chapter 10. Current State of Knowledge of Reef Mollusks in Cuba -- Chapter 11. Herbivory on Cuban Coral Reefs -- Chapter 12. Chronology of the Lionfish Invasion in Cuba and Evaluation of Impacts on Native Reef Fishes -- Chapter 13. Sharks and Rays in Cuban Coral Reefs: Ecology, Fisheries, and Conservation -- Chapter 14. Mesophotic Coral Ecosystems of Cuba -- Part V. Ecology, Conservation and Management -- Chapter 15. Status of Cuban Coral Reefs -- Chapter 16. Population Genetics of Cuba’s Scleractinian Corals -- Chapter 17. Multiple Cumulative Effects on Coral Reefs of the Northwestern Cuban Region -- Chapter 18. Guanahacabibes National Park: Research, Monitoring and Man-Agement for the Conservation of Coral Reefs -- Chapter 19. Ciénaga de Zapata Biosphere Reserve: Integrating Science with the Management of Coral Reefs -- Chapter 20. Coral Reefs in Cuban Marine Protected Areas -- Part VI. Economic Valuation -- Chapter 21. Economic Valuation of the Coral Reefs of Jardines de la Reina and Punta Francés National Parks, Cuba -- Chapter 22. The Economic Value of Coral Reefs in the Context of Marine Protected Areas: Experiences of the South Cuban Archipelago Project -- Chapter 23. Fish Can Be More Valuable Alive Than Dead.
    Abstract: This comprehensive volume gathers foremost experts on the coral reefs of Cuba who represent a spectrum of disciplines, including biology, conservation ecology, economics and geology. The volume is organized along general themes including the Cuban Reef biota, reefs occurring in the Mesophotic and Eutrophic zones, ecology, conservation, management and the economic importance of the coral reefs of Cuba. The combination of case studies, new and previously published research, historical overview and examples of the ways in which research has contributed to the management and conservation of Cuban coastal resources provides a unique reference for graduate students and professionals holding a wide range of interests and expertise related to coral reef systems.
    Type of Medium: Online Resource
    Pages: XI, 438 p. 176 illus., 147 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031367199
    Series Statement: Coral Reefs of the World, 18
    DDC: 577.6
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Ecology . ; Oceanography. ; Bioclimatology. ; Environmental management. ; Freshwater and Marine Ecology. ; Biodiversity. ; Biooceanography. ; Climate Change Ecology. ; Environmental Management. ; Ocean Sciences.
    Description / Table of Contents: Chapter 1. A Global View of the Cold-Water Coral Reefs of the World -- Chapter 2. Biology, Ecology and Threats to Cold-Water Corals on Brazil’s Deep-Sea Margin -- Chapter 3. Cold-Water Corals of the World: Gulf of Mexico -- Chapter 4. Cold-Water Coral Reefs of the Southeastern United States -- Chapter 5. Norwegian Coral Reefs -- Chapter 6. Waters of Ireland and the UK -- Chapter 7. Life and Death of Cold-Water Corals across the Mediterranean Sea -- Chapter 8. Cold-Water Coral Reefs in the Oxygen Minimum Zones off West Africa -- Chapter 9. New Zealand: South West Pacific Region -- Chapter 10. Deep-Sea Corals of the North and Central Pacific Seamounts.
    Abstract: Cold-water corals form reef structures in continental margin and seamount settings world-wide, making them more wide-spread and abundant than shallow-water reefs. Their role in these ecosystems is no less important than the influence that shallow-water coral reefs have on tropical systems. They create habitat structure, host endemic species, enhance elemental cycling, alter current flow, sequester carbon, and provide many other ecosystem services that we are just beginning to understand. The rapidly evolving state of knowledge of cold-water and deep-sea coral reefs has not been compiled in over 10 years. This volume synthesizes recent and historical information, reveals new findings from reefs that have been discovered only recently, and presents key avenues for future research. We are on the cusp of understanding the critical role that cold-water coral reefs play in the world’s oceans, and this book lays the foundation on which this knowledge will be built in the future.
    Type of Medium: Online Resource
    Pages: XVI, 293 p. 107 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031408977
    Series Statement: Coral Reefs of the World, 19
    DDC: 577.6
    Language: English
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  • 11
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Immunotherapy. ; Cancer Genetic aspects. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Tumour Immunology. ; Immunotherapy. ; Cancer Genetics and Genomics. ; Cancer Stem Cells.
    Description / Table of Contents: Interdisciplinary Approach in Hepatobiliary Cancers -- Liver Cancer: Interdisciplinary Approach -- The Immune System in Liver Cancer: From Beginning to Progression -- The Tumor Microenvironment in Hepatocellular Carcinoma -- Metabolic Alterations of Hepatocellular Cancer Stem Cells -- Τhe Role of Senescence in NASH-related HCC -- Regulators of Genetic Risk for the Progression of Non-alcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Reconstruction of Transcriptional Network and Signature-Based Metabolic Profiling -- Tumor Microenvironment and Immunotherapy in Advanced Biliary Tract Cancers -- Fibrosis and Immunotherapy in Hepatocellular Carcinoma -- Liver Cancer and the Curative Potential of Nanomedicine -- Locoregional Therapies for Hepatocellular Carcinoma -- Drug Resistance in Hepatocellular Carcinoma -- Liver Stereotactic Body Radiotherapy.
    Abstract: Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.
    Type of Medium: Online Resource
    Pages: XI, 365 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031445286
    Series Statement: Interdisciplinary Cancer Research, 3
    DDC: 571.978
    Language: English
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  • 12
    Keywords: Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Zoology. ; Sustainability. ; Population biology. ; Conservation biology. ; Ecology . ; Freshwater and Marine Ecology. ; Biodiversity. ; Zoology. ; Sustainability. ; Population Dynamics. ; Conservation Biology.
    Description / Table of Contents: Part I. Fish Resources and Fishing Areas of the Western Balkans -- Chapter 1. Fish Resources of Inland Waters and Fisheries in Slovenia, Management, Sustainability and Conservation -- Chapter 2. Inland Fisheries in Croatia: Historical Aspects, Fish Resources, Management and Conservation -- Chapter 3. Fish Resources and Fisheries in Bosnia and Herzegovina – Overview, Sustainability, and Conservation -- Chapter 4. Inland Fisheries in Serbia: Historical Aspect, Fish Resources, Management and Conservation -- Chapter 5. The Freshwater Fish Resources and Freshwater Fisheries of Montenegro, Management, Sustainability and Conservation – With a Special Perspective on Lake Skadar -- Chapter 6. Fish and Fisheries of the Republic of North Macedonia, Current Situation and Its Perspective -- Chapter 7. Fish Resources of Inland Waters and Fisheries in Albania, Management, Sustainability and Conservation -- Part II. Some Fish Species of the Western Balkans Important for Fisheries and Conservation -- Chapter 8. Freshwater Crayfish of Western Balkan: Is It Possible to Use Them Sustainably or Do They Need Prompt Conservation Actions? -- Chapter 9. Salmonid Fish Species – Opportunities for Sustainable Use under Multiple Pressures and Current Climatic Change -- Chapter 10. Past and Future of Sturgeon Species (Acipenseridae) in Western Balkans – Case for Permanent Conservation or Sustainable Management -- Part III. Effects of Stressors on Inland Water Ecosystems and Fish Resources -- Chapter 11. Eutrophication of Fishing Waters and the Influence of Cyanobacterial Occurrence and Blooming on Fish Resources – Case Studies in Serbia -- Chapter 12. Pollution of Fishing Waters of the Western Balkan – Potentially Toxic Elements and Their Impact on the Ecological Sustainability of Fish Resources -- Chapter 13. Invasive Macroinvertebrate and Fish Species and Their Impact on Fish Resources: A Case Study on Fishing Waters of Serbia -- Part IV. Fish Stock Assessment Methods -- Chapter 14. A Brief Overview of the Development of the ES-HIPPO Model for Assessing the Sustainability and Conservation Priorities of Fish, Fish Resources, and Inland Water Habitats -- Part V. Conservation and Aquaculture -- Chapter 15. Тhe Role and Importance of Aquaculture for the Ecological Sustainability of Fish Resources in the Inland Water of Serbia -- Chapter 16. Huchen Hucho hucho (Linnaeus, 1758) in Croatia: Distribution, Genetic Diversity, Threats and Conservation -- Chapter 17. Future Perspective of Sustainable Development of Freshwater Fisheries and Conservation of Threatened Fish Species, Crustaceans and Molluscs -- Part VI. Social Aspect -- Chapter 18. Political and Socio-Economic aspects of Fisheries in Inland and Coastal Waters of the Western Balkan -- Chapter 19. Fish Resources of the Western Balkans, Sustainable Use and/or Conservation?.
    Abstract: This book provides a detailed evaluation of the hydro-ecological characteristics of the Western Balkans, an area characterized by still preserved inland waters and fish resources important for the European continent, as well as the biodiversity of inland waters important for the planet Earth. Freshwater ecosystems cover only 1% of the Earth's surface; however, they are a habitat for about 40% of fish species. At the same time, inland fisheries make less than 12% of the world's global fish catch, with 43% coming from low-income and food-deficient countries (Africa, South America, Southeast Asia). In Europe, the Western Balkans have significant fishing waters and fish resources, including the Middle Danube drainage (Sava, Drina, Velika Morava river systems), large ancient lakes (Skadar/Shkodra, Ohrid, Prespa, Dojran), and the Adriatic basin characterized by endemic and commercially important species. However, in contrast to the high fishing potential in a significant part of the Western Balkans, diverse and specific political, economic, and social factors largely had a negative impact on the state of fish resources. This volume is multidisciplinary and provides a sound knowledge base for scientific and practical fisheries. In addition, it may be a valuable guide for managers and conservationists worldwide to adapt methods and procedures for the ecological sustainability of fish resources under specific local, natural, and socio-economic conditions. Finally, the content is a good reference for natural sciences and agriculture students studying fish, fish resources, and fisheries sciences. It would improve their knowledge and perspectives on the challenges of sustainable use and conservation of inland water resources.
    Type of Medium: Online Resource
    Pages: XXII, 707 p. 261 illus., 233 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031369261
    Series Statement: Fish & Fisheries Series, 43
    DDC: 577.6
    Language: English
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  • 13
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Cancer. ; Cancer Treatment. ; Oncology. ; Immunotherapy. ; Tumors Immunological aspects. ; Nanomedicine. ; Cancer Biology. ; Cancer Therapy. ; Oncology. ; Immunotherapy. ; Tumour Immunology. ; Cancer Nanotechnology.
    Description / Table of Contents: Interdisciplinary Approach in Gastrointestinal Cancers -- Gastrointestinal Cancers: What Is the Real Board of Microenvironment and the Role of Microbiota-Immunity Axis -- Epithelial-Mesenchymal Transition in Gastrointestinal Cancer: From a Basic to a Clinical Approach -- Metabolomics of Gastrointestinal Cancers -- Deregulation of Immune System in Gastric Cancer Development, How Immune Nutrition Might Restore the Functions of Immune Cells -- Helicobacter pylori Virulence Factors, Pathogenicity, and Gastric Cancer -- Gastric Cancer and Helicobacter pylori -- Role of Neuromodulators in Regulation of the Tumor Microenvironment of Gastric and Colorectal Cancers -- The Role of Tumor Microenvironment in Colon Cancer -- Unraveling the Esophageal Cancer Tumor Microenvironment: Insights and Novel Immunotherapeutic Strategies -- The Interplay Between Immunity and Gut Microbiota in Colon Cancer -- Immunotherapy in Gastrointestinal Cancer Focusing on CAR-T Cell Therapy -- Development of Biocompatible Nanocarriers for the Treatment of Colorectal Cancer -- Challenges of Onco-therapeutics in Early Onset Colorectal Cancer -- Unintentional Weight Loss and Malnutrition After Esophageal Cancer and Treatment -- Current Clinical Landscape of Immunotherapeutic Approaches in Pancreatic Cancer Treatment. The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy. .
    Abstract: Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.
    Type of Medium: Online Resource
    Pages: XI, 404 p. 22 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031483714
    Series Statement: Interdisciplinary Cancer Research, 4
    DDC: 571.978
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Animal biotechnology. ; Ecology . ; Oceanography. ; Food science. ; Freshwater and Marine Ecology. ; Animal Biotechnology. ; Biooceanography. ; Food Engineering.
    Description / Table of Contents: Diversity, Distribution, and Biology of Sea Cucumber -- Nutritional Components of Sea Cucumber and the Biochemical Characteristics of Autolytic Enzymes -- The Functional Components of Sea Cucumber and their Nutritional and Biological Activities -- Traditional Processing Technologies and Products of Sea Cucumber: Historical Review -- The Pretreatment Technology of Raw Sea Cucumber and New Processing Technology of Salted Sea Cucumber -- The New Processing Technology of Dried Sea Cucumber Products -- Ready-to-Eat Sea Cucumber Products and Collagen Stabilization Technology -- The Extraction, Separation Technology and New Product Development of Sulfated Polysaccharides from Sea Cucumber -- The Extraction, Separation Technology and New Product Development of Functional Lipids from Sea Cucumber -- The Extraction, Separation Technology and New Product Development of Collagen Peptides from Sea Cucumber -- The Quality Management Systems and Standards of Sea Cucumber Products -- Food Safety Issues and Regulatory Requirements of Sea Cucumber Products and Their Internationalization.
    Abstract: Sea cucumbers belong to the Phylum Echinodermata. There are more than 900 recorded species of sea cucumber of which more than 40 are edible. As a food source, sea cucumbers are rich in protein, low in fat, rich in collagen, sulfated polysaccharides, phospholipids, glycolipids, saponins and other functional components. Therefore, sea cucumbers have important nutritional and medicinal value. Growing awareness of these health benefits has promoted growth in marine aquaculture and processing technologies for the development of sea cucumber products for many applications.Novel perspectives of nutritional functions and processing technologies of sea cucumbers are defined in this book. The chemical structure and nutritional function of sea cucumbers are systematically reviewed. These include the functional/nutritional components, the endogenous enzymatic properties related to processing efficiency and product quality, and the efficient preparation technology of functional components. The traditional processing technology is presented as the background context to highlight the advances in new processing technologies including low-temperature cooking technology based on controllable negative pressure system, heat pump-hot-blast air combined drying technology, microwave sterilization of instant sea cucumber, collagen stabilization technology. The book finishes with the authentication of sea cucumber types and origin, quality standards, product quality control systems and food safety requirements.
    Type of Medium: Online Resource
    Pages: VI, 364 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031165122
    Series Statement: Advances in Marine Bioprocesses and Bioproducts,
    DDC: 577.6
    Language: English
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  • 15
    Keywords: Cancer. ; Oncology. ; Medical screening. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Oncology. ; Cancer Screening. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Chapter 1. Introduction: The Application of AI in Precision Oncology: Tailoring Diagnosis, Treatment, and the Monitoring of Disease Progression to the Patient -- Part I. Artificial Intelligence for Screening, Diagnosis, Monitoring in Precision Oncology -- Chapter 2. Application of AI in Novel Biomarkers Detection that Induce Drug Resistance, Enhance Treatment Regimens and Advancing Precision Oncology -- Chapter 3. Use of Artificial Intelligence in Implementing Mainstream Precision Medicine to Improve Traditional Symptom-driven Practice of Medicine: Allowing Early Interventions and Tailoring better-personalized Cancer Treatments -- Chapter 4. AI as a Novel Approach for Exploring ccfNAs in Personalized Clinical Diagnosis and Prognosis: Providing Insight into the Decision-Making in Precision Oncology -- Chapter 5. AI-Enhanced Digital Pathology and Radiogenomics in Precision Oncology -- Part II. Artificial Intelligence and Omics in Precision Oncology -- Chapter 6. Epigenetics Analysis Using Artificial Intelligence in the Era of Precision Oncology -- Chapter 7. Association of Metabolomics with AI in Precision Oncology: Emerging Perspectives for More Effective Cancer Care -- Chapter 8. Artificial Intelligence Application to Microbiomics Data for Improved Clinical Decision Making in Precision Oncology -- Part III. Artificial Intelligence in Cancer Therapy and the Clinical Applications -- Chapter 9. AI and Nanotechnology in Realizing the Goal of Precision Medicine: Tailoring the Best Treatment for Personalized Cancer Treatment -- Chapter 10. Artificial Intelligence-Based Medical Devices Revolution in Cancer Screening: Impact into Clinical Practice -- Chapter 11. Intelligent Drug Design and Use for Cancer Treatment: The Roles of AI and Precision Oncology in Targeting Patient-Specific Splicing Profiles -- Chapter 12. Applying Artificial Intelligence Prediction Tools for Advancing Precision Oncology in Immunotherapy: Future Perspectives in Personalized Care -- Chapter 13. Employing AI-Powered Decision Support Systems in Recommending the Most Effective Therapeutic Approaches for Individual Cancer Patients: Maximizing Therapeutic Efficacy -- Chapter 14. AI-Pathway Companion in Clinical Decision Support: Enabling Personalized and Standardized Care Along Care Pathways in Oncology -- Chapter 15. AI Tools Offering Cancer Clinical Applications for Risk Predictor, Early Detection, Diagnosis, and Accurate Prognosis: Perspectives in Personalised Care -- Chapter 16. Conclusion and Insights into the Future of AI in Precision Oncology.
    Abstract: This book highlights the use of artificial intelligence (AI), big data and precision oncology for medical decision making in cancer screening, diagnosis, prognosis and treatment. Precision oncology has long been thought of as ideal for the management and treatment of cancer. This strategy promises to revolutionize the treatment, control, and prevention of cancer by tailoring tests, treatments and predictions to specific individuals or population groups. In order to accomplish these goals, vast amounts of patient or population group specific data needs to be integrated and analysed to be able to identify key patterns or features which can be used to define or characterize the disease or the response to the disease in these individuals. These patterns or features can be as varied as molecular patterns or features in medical images. This level of data analysis and integration can only be achieved through the use of AI. The book is divided into three parts starting with a section on the use of artificial intelligence for screening, diagnosis and monitoring in precision oncology. The second part: Artificial intelligence and Omics in precision oncology, highlights the use of AI and epigenetics, metabolomics, microbiomics in precision oncology. The third part covers artificial intelligence in cancer therapy and its clinical applications. It also highlights the use of AI tools for risk prediction, early detection, diagnosis and accurate prognosis. This book, written by experts in the field from academia and industry, will appeal to cancer researchers, clinical oncologists, pathologists, medical students, academic teaching staff and medical residents interested in cancer research as well as those specialising as clinical oncologists.
    Type of Medium: Online Resource
    Pages: XIV, 315 p. 64 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031215063
    DDC: 571.978
    Language: English
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  • 16
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.
    Description / Table of Contents: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.
    Abstract: This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.
    Type of Medium: Online Resource
    Pages: XXI, 542 p. 229 illus., 221 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031162862
    DDC: 571.978
    Language: English
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  • 17
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancers. ; Cancer Therapy. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Chapter 1 An introduction to breast cancer -- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators -- Chapter 4 Cell cycle and cancer -- Chapter 5 cell cycle dysregulation in breast cancer -- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation -- Chapter 7 Breast tumor micro environment and CDks -- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis -- Chapter 9 CDK1 Dysregulation in Breast Cancer -- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers -- Chapter 11 Therapeutic implications of CDKs in Breast Cancer -- Chapter 12 Novel CDK Inhibitors in Breast Cancer -- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach -- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer -- Chapter 15 CDk inhibitor for treatment of breast cancer -- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer -- Chapter 17 Different cyclins and their significance in Breast cancer.
    Abstract: This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.
    Type of Medium: Online Resource
    Pages: XVII, 373 p. 133 illus., 92 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811989117
    DDC: 571.978
    Language: English
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  • 18
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Biotic communities. ; Zoology. ; Biodiversity. ; Freshwater and Marine Ecology. ; Ecosystems. ; Zoology. ; Biodiversity.
    Description / Table of Contents: Habitat: Sunlit Rocky Grounds -- Habitat: Shady Rocky Grounds -- Habitat: Dark Caves -- Habitat: Intertidal Zone -- Habitat: Sandy Grounds -- Habitat: Seagrass -- Habitat: Muddy Grounds -- Habitat: Open Waters -- Humans and the Sea.
    Abstract: This book invites snorkelers and divers on an educational visit to the most important ecosystems of the Mediterranean Sea. Keystone species from brown algae to dolphins are presented in their marine habitats and understood as part of a complex ecological system. Instead of grouping animals and plants taxonomically, we have organised them according to the eight main habitats of the Mediterranean Sea. Our journey starts with different types of rocky grounds, then takes you further to the Mediterranean’s sandy and muddy grounds, and finally ends with the fish and dolphins of the blue open sea. You will be introduced to 220 ecologically significant animal and plant species via the texts of Daniel Abed-Navandi, a long-time lecturer on the biodiversity of the Mediterranean Sea at the University of Vienna, and the photographs of Georg Glaeser, the master behind the camera, who captures marine life on the spot.
    Type of Medium: Online Resource
    Pages: VIII, 200 p. 406 illus., 404 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031223341
    DDC: 577.6
    Language: English
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  • 19
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Freshwater ecology. ; Marine ecology. ; Computer simulation. ; Computer science Mathematics. ; Freshwater and Marine Ecology. ; Computer Modelling. ; Mathematical Applications in Computer Science.
    Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Processing method of the original data -- Chapter 3 Grey correlation analysis -- Chapter 4 Grey Clustering Analysis -- Chapter 5 Grey System Modeling -- Chapter 6 Grey Prediction -- Chapter 7 Grey decision-making -- Chapter 8 Grey Linear Programming -- Chapter 9 Grey Dynamic Control.
    Abstract: This book reviews the gray system and combines its latest research results in fishery science. The chapters cover the basic concept and theory of gray system, original data processing and gray sequence generation, gray correlation analysis, gray cluster analysis, gray system modeling, gray prediction, gray decision-making, and gray linear programming. The theory of gray system is a new cross-sectional discipline founded in 1982 by Professor Deng Julong, a well-known scholar in China. In recent decades, it has not only been deepened and expanded in theory but also widely used in the fields of society, economy, ocean, agriculture, fishery, and other fields, and made a series of significant scientific achievements. These have laid the foundation for the important position of the gray system theory. Due to the great uncertainty of the fishery resources and the fishery environment involved in the fishery science system, which is completely different from the natural resources on the land, the data and information belong to the category of “poor information”, and the variability and uncertainty are greater than other natural resources. As an extremely effective analytical method and tool, gray system theory has been applied increasingly in fishery science. The book is developed based on well-read and practical literature and will help scientists and research units engaged in scientific research and teaching in fishery science and related fields to develop new research methods and tools. .
    Type of Medium: Online Resource
    Pages: VII, 196 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819906352
    DDC: 577.6
    Language: English
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  • 20
    Keywords: Cancer. ; Cancer Genetic aspects. ; Oncology. ; Therapeutics. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Oncology. ; Therapeutics.
    Description / Table of Contents: Chapter 1 Evolution of translational cancer therapeutics -- Chapter 2 Oncology: Way forward from clinical and molecular diagnosis to treatment -- Chapter 3 Oncogenic genomics alterations in cancer patient -- Chapter 4 Altered mRNA expression profiles in cancer patients -- Chapter 5 microRNAs and long non-coding RNAs as key targets -- Chapter 6 Oncogenic alterations translated into diagnostics -- Chapter 7 Precision medicine in oncology -- Chapter 8 Precision medicine – translation of individualistic treatment in oncology -- Chapter 9Pharmacogenetics and Pharmacogenomics in Precision Medicine -- Chapter 10 Pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines -- Chapter 11 Biomarkers in Precision Medicine in oncology -- Chapter 12 Bioinformatics and biostatistics in Precision Medicine -- Chapter 13 Omics in Precision medicine -- Chapter 14 Translational therapeutic targets : from bench to clinical trials -- Chapter 15 Strength of integartive genomic alterations, precision medicine and therapeutic targets as treatment choice in patient care.
    Abstract: This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.
    Type of Medium: Online Resource
    Pages: XVI, 274 p. 23 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819915293
    DDC: 571.978
    Language: English
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  • 21
    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Cancer. ; Cancer Treatment. ; Stem cells. ; Cytology. ; Medical genetics. ; Immunology. ; Cancer Biology. ; Cancer Therapy. ; Cancer Stem Cells. ; Cell Biology. ; Medical Genetics. ; Immunology.
    Description / Table of Contents: Interdisciplinary Approaches in Cancer Research -- Role of Immune Cells in the Tumor Microenvironment -- Spatial Transcriptomic Approaches for Understanding the Tumor Microenvironment (TME) -- Role of Mesenchymal Stem/Stromal Cells in Cancer Development -- Cancer-associated Fibroblasts and Their Role in Cancer Progression -- The Role of Tumoroids in Cancer Research -- Myokines Expression in Cancer Cachexia -- Epigenetics in Cancer Biology -- Epigenetic Regulation of Cancer by Natural Touch: Phytochemicals and Epigenetic Regulation -- Telomerase Reverse Transcriptase in Humans: From Biology to Cancer Immunity -- Molecular Mechanisms of Metal-induced Carcinogenesis -- Epi-drugs Targeting RNA Dynamics in Cancer -- Oncologic Emergencies: Pathophysiology, Diagnosis, and Initial Management -- Malignancies in Inborn Errors of Immunity -- Hematopoietic Stem Cell Transplantation in Patients with Inborn Errors of Immunity and Malignancy -- Personalized Immuno-oncology with Immunodeficiency Mouse Models -- Allergy and Cancer: New Perspectives -- Depression and Cancer: the Inflammatory Bridge -- Impact of Cancer-Related Sarcopenia on Systemic Immune Status -- Surveillance of Subclinical Cardiovascular Complications in Childhood Cancer Survivors: Exercise as a Diagnostic and Therapeutic Modality.
    Abstract: Cancer is a major public health concern and one of the leading causes of death. There is no simple solution for this complex disease, therefore interdisciplinary approaches might help to find solutions to many unanswered questions and challenges about cancer. The rapid flow of interdisciplinary research in cancer during recent years has increased our understanding of the nature of cancers. Such interdisciplinary approaches could be helpful for both the diagnosis and the development of more effective therapeutic strategies. The “Interdisciplinary Cancer Research” series publishes comprehensive volumes on different cancers and presents the most updated and peer-reviewed articles on human cancers. Over the past decade, increased cancer research has greatly improved our understanding of the nature of cancerous cells which has led to the development of more effective therapeutic strategies to treat cancers. This interdisciplinary series is of special value to researchers and practitioners working on cell biology, immunology, hematology, biochemistry, genetics, oncology and related fields. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN).
    Type of Medium: Online Resource
    Pages: XI, 611 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324581
    Series Statement: Interdisciplinary Cancer Research, 1
    DDC: 571.978
    Language: English
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  • 22
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Stem cells. ; Cytology. ; Developmental biology. ; Cancer Stem Cells. ; Cell Biology. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Assays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis.
    Abstract: This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understanding of the role of autophagy in stem cells, including germline stem cells. Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 41 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031173622
    Series Statement: Stem Cell Biology and Regenerative Medicine, 73
    DDC: 571.978
    Language: English
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  • 23
    Keywords: Freshwater ecology. ; Marine ecology. ; Biotic communities. ; Environmental management. ; Environmental education. ; Freshwater and Marine Ecology. ; Ecosystems. ; Environmental Management. ; Environmental and Sustainability Education.
    Description / Table of Contents: Part I: Introduction And Context -- Chapter 1: Introduction And Context -- Part II: Case Studies -- Chapter 2: Kenya Case Study One -- Chapter 3: Guatemala Case Study -- Chapter 4: Ghana Case Study One -- Chapter 5: Pacific Island Case Study -- Chapter 6: Saudi Arabia Case Study -- Chapter 7: Philippines Case Study One -- Chapter 8: Kenya Case Study Two -- Chapter 9: Tanzania Case Study -- Chapter 10: Indonesia Case Study -- Chapter 11: Panama Case Study -- Chapter 12: Philippines Case Study Two -- Chapter 13: Bangladesh Case Study -- Chapter 14: Ghana Case Study Two -- Chapter 15: Ecuador Case Study -- Chapter 16: Thailand Case Study -- Chapter 17: Peru Case Study -- Part III: Evaluation And Synopsis -- Chapter 18: Evaluation And Synopsis.
    Abstract: This book focuses on tropical coasts, which are highly vulnerable due to a multitude of stressors. Population growth is substantial, habitats are lost and biodiversity is reduced at an alarming rate, severely affecting many ecosystem services. This situation calls for sound coastal management and the effective engagement of all relevant stakeholders. About two decades ago the M.Sc. program ISATEC (International Studies in Aquatic Tropical Ecology) was created at Bremen University (Germany) to train young scientists for a professional engagement in the complex field of tropical coastal and resource management. This book provides a platform for those Alumni to report on their work experiences and findings in their home countries and covers all regions of the tropical belt. Part I of the book provides a short review of the state of the tropical ocean and its resources and of international attempts towards sustainable ocean management starting with the Rio Declaration on Environment and Development in 1992. Part II deals with country case studies, and part III focuses on an evaluation & synopsis of those contributions. Emerging key issues for management and conservation of the tropical coastal environments are presented and critical challenges on the path towards reaching the Sustainable Development Goals (SDGs) are discussed, as are the needs for enhancing research and capacity development. .
    Type of Medium: Online Resource
    Pages: XII, 344 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031178795
    DDC: 577.6
    Language: English
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  • 24
    Keywords: Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Ecology . ; Oceanography. ; Environmental education. ; Welfare economics. ; Freshwater and Marine Ecology. ; Biodiversity. ; Biooceanography. ; Environmental and Sustainability Education. ; Social Economy.
    Description / Table of Contents: 1. The future of food from the sea -- Chapter 2.The Expected Impacts of Climate Change on the Ocean Economy -- Chapter 3. What Role for Ocean-Based Renewable Energy and Deep-Seabed Minerals in a Sustainalble Future? -- Chapter 4. The Ocean Genome: Conservation and the Fair, Equitable and Sustainable Use of Marine Genetic Resources -- Chapter 5. Leveraging Multi-Target Strategies to Address Plastic Pollution in the Context of an Already Stressed Ocean -- Chapter 6. Technology, Data and New Models for Sustainably Managing Ocean Resources -- Chapter 7. Coastal Development: Resilience, Restoration and Infrastructure Requirements -- Chapter 8. National Accounting for the Ocean and Ocean Economy -- Chapter 9. Ocean Finance -- Chapter 10. Critical Habitats and Biodiversity: Inventory, Threshold and Governance -- Chapter 11. The Human Relationship with Our Ocean Planet -- Chapter 12. The Ocean Transition: What to Learn from System Transitions -- Chapter 13. Towards Ocean Equity -- Chapter 14. Integrated Ocean Management -- Chapter 15. Illegal, Unreported and Unregulated Fishing and Associated Drivers -- Chapter 16. Organised Crime Associated with Fisheries -- Chapter 17. The Ocean as a Solution to Climate Change: Five Opportunities for Action -- Chapter 18. A Sustainable Ocean Economy for 2050: Approximating Its Benefits and Costs -- Chapter 19. A Sustainable & Equitable Blue Recovery to the COVID-19 Crisis -- Chapter 20. Ocean Solutions That Benefit People, Nature and the Economy -- Chapter 21. Transformations for a Sustainable Ocean Economy: A Vision for Protection, Production and Prosperity.
    Abstract: Home to over 80 percent of all life on Earth, the ocean is the world’s largest carbon sink and a key source of food and economic security for billions of people. The relevance of the ocean for humanity's future is undisputed. However, the ocean’s great potential to drive economic growth and equitable job creation, sustain healthy ecosystems, and mitigate climate change is not yet fully recognised. Lack of awareness of this potential as well as management and governance challenges pose impediments. Until these impediments are removed, ocean ecosystems will continue to be degraded and opportunities for people lost. A transition and a clear path to a thriving and vibrant relationship between humans and the ocean are urgently needed. This open access collection of papers and reports identifies a path that is inspired by science, energised by engaged people, and emboldened by visionary leaders. These assessments of knowledge are commissioned by the High Level Panel for a Sustainable Ocean Economy (Ocean Panel), which was established in September 2018 as a unique initiative led by heads of state and government from around the world, to showcase the latest leading-edge science, knowledge and state-of-the-art thinking on key ocean issues. Altogether, The Blue Compendium offers innovative ocean solutions in technology, policy, governance, and finance realms, that could help accelerate a transition to a more sustainable and prosperous relationship with the ocean. The comprehensive assessments have already informed policy making at the highest levels of government and motivated an impressive array of responsive and ambitious action across a growing network of leaders in business, finance and civil society. .
    Type of Medium: Online Resource
    Pages: XII, 915 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031162770
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Biology Technique. ; Stem cells. ; Cancer Biology. ; Biological Techniques. ; Cancer Stem Cells. ; Stem Cell Biology.
    Description / Table of Contents: 1. On the origin of cancer -- 2. Culture of Cells: Basic Principles -- 3. Stem cell culture from embryos -- 4. Reprogramming of normal cells -- 5. Maintenance of human Pluripotent Stem Cells -- 6. Identification of cancer stem cells by different molecular markers -- 7. Enrichment of Cancer Stem Cell from malignant tumor -- 8. Isolation of single clonal cell from primary cultured cells and establishment of a cancer stem cell line -- 9. Artificial Generation of Cancer Stem Cells from Normal Stem Cells -- 10. Quick method to assess non-mutagenic carcinogens with iPS cells -- 11. Self-renewal potential of caner stem cells -- 12. Differentiation potential of cancer stem cells in vitro -- 13. Tumor Angiogenesis by cancer stem cells in vivo -- 14. Invasion and Metastatic potential of cancer stem cells in vitro -- 15. Metastatic potential of cancer stem cells In Vivo- 16. Anchorage-independent cell growth assay for Cancer Stem Cells: Tumorigenic assay in vitro -- 17. Tumorigenic potential of cancer stem cells in vivo -- 18. Development of immunoliposomes using monoclonal antibodies targeting cancer stem cells -- 19. In-vitro evaluation of anti-cancer stem cell drugs -- 20. In vitro Tumoroid Model Using Cancer Stem Cells.
    Abstract: This book describes the use of stem cells and cancer stem cell generation in the inflammatory microenvironment (cancer-inducing niche) using induced pluripotent stem cells. It provides step-by-step techniques and manuals for studying stem cell and cancer stem cell generation with different applications in cancer research. The development of induced pluripotent stem cells has provided a new approach to studying cancer initiation by producing cancer stem cells without introducing mutations or foreign genes. The book features the research of the authors’ group, which was the first to generate cancer stem cells from stem cells in the presence of inflammatory conditions. The 20 chapters if this book cover topics such as generating pluripotent stem cells, converting normal stem cells to cancer stem cells, enriching, isolating and evaluating cancer stem cells. Methods for evaluating the characteristics of cancer stem cells and possible therapies against them are also discussed. The book provides easy-to-follow protocols that help researchers in the study of cancer stem cells. Illustrations help readers understand how the method of cancer stem cell generation can be applied as an essential method for assessing the carcinogenic potential of various non-mutagenic compounds. It will be a useful resource for graduate students, researchers, technicians, and physicians working in academic, hospital, and pharmaceutical settings. .
    Type of Medium: Online Resource
    Pages: XVII, 243 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819913312
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Cancers. ; Cancer Therapy. ; Cancer Biology. ; Tumour Immunology.
    Description / Table of Contents: Chapter 1. Hypoxia and its Biological Implications for Cancer Therapy -- Chapter 2. Hypoxia's function in cancer -- Chapter 3. Role of Hypoxia and Reactive Oxygen Species in cancer biology -- Chapter 4. Hypoxic tumor microenvironment: driver for cancer progression -- Chapter 5. Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression -- Chapter 6. Hypoxia Regulated Gene Expression and Metastasis -- Chapter 7. piRNA based cancer therapy in hypoxic tumor -- Chapter 8. MicroRNA Signatures of Tumor Hypoxia -- Chapter 9. Hypoxia and the Metastatic Cascade -- Chapter 10. Hypoxia and Extra Cellular Matrix-major drivers of tumor Metastasis -- Chapter 11. Role of Hypoxia in Cancer Therapy – Introduction -- Chapter 12. Hypoxic regulation of telomerase gene expression in cancer -- Chapter 13. CRISPR/Cas9-editing-based modeling of tumor hypoxia -- Chapter 14. Tumor-on-a-chip: Microfluidic models for Hypoxic tumor microenvironment -- Chapter 15. Imaging the Hypoxic Tumor microenvironment in cancer models -- Chapter 16. Hypoxia-targeting drugs as new cancer chemotherapy agents Hypoxia-targeting drugs as new cancer chemotherapy agents - Molecular Insights -- Chapter 17. Identification of Hypoxia targeting drugs in the tumor microenvironment and prodrug Strategies for Targeting Tumor Hypoxia -- Chapter 18. Hypoxia Induced Apoptosis in Cancer Development -- Chapter 19. Hypoxia in drug resistance and radioresistance.
    Abstract: This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.
    Type of Medium: Online Resource
    Pages: XV, 447 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819903139
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Animal models. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Models. ; Cancer Therapy. ; Cancer Genetics and Genomics. ; Cancer Microenvironment.
    Description / Table of Contents: Chapter 1: Cancer as a Disease of Cell Proliferation -- Chapter 2: Genetic and Chromosomal Instability -- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function -- Chapter 4: The DNA Damage Checkpoint -- Chapter 5: Dynamics of the Spindle Assembly Checkpoint -- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance -- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy -- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy -- Chapter 9: The Cancer Stem Cell and Tumour Progression -- Chapter 10: Evading the antitumour immune response -- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention -- Chapter 12: In science, all conclusions are provisional.
    Abstract: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.
    Type of Medium: Online Resource
    Pages: XIV, 269 p. 96 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031325731
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Physiology. ; Ecology . ; Evolution (Biology). ; Anatomy, Comparative. ; Freshwater and Marine Ecology. ; Animal Physiology. ; Evolutionary Ecology. ; Animal Anatomy.
    Description / Table of Contents: PREFACE AND ACKNOWLEDGEMENTS -- SECTION I – IN THE BEGINNING -- CHAPTER 1. WADING IN ̶ INTRODUCTION TO THE FISH-BIRD -- General Discussion of Penguins and Substance of the Book -- An Impressive Number of Penguin Species: Evolution of Their Unique Capabilities -- Penguin Species Radiation and the Ontogeny of Their Watery World -- Penguin Evolution: Body Size and Climate -- Penguin Evolution: Radiation into Vacant Niches -- Penguin Evolution: Body Size and Crossing the Sea-Land Boundary -- CHAPTER 2. LAND AHOY! A TIRESOME BUSINESS -- Crossing the Land-Ocean Interface is Affected by Body Size -- Why and How Often do Penguins Come Ashore? -- Tying Land-life to the At-sea Life of Fish-Birds: Foraging and Breeding -- Success Vary with Prey Availability -- Molt ̶Necessary, Brief Respite from the Sea -- SECTION II – PENGUIN MARINE HAUNTS AND FOOD HABITS -- CHAPTER 3.FISH-BIRDS AT HOME IN THEIR OCEAN HABITATS -- Oceanographic Fronts and Water Masses Important to Penguins: General Discussion -- Penguins Require High Productivity Water Masses -- Large Scale: Oceanographic Boundaries and At-sea Distributions of Penguins -- Southern Boundary of the Antarctic Circumpolar Current -- Emperor and King penguins -- Adélie and Chinstrap penguins -- Antarctic Polar Front and Subantarctic Front -- Gentoo and Yellow-eyed penguins -- Macaroni and Royal penguins -- Northern and Southern Rockhopper, Fiordland, Snares penguins -- Subtropical Front and Continental Boundary Currents -- Galápagos, Humboldt, Magellanic, African penguins -- Little penguins -- Meso- and Small-Scale Ocean Processes Facilitating Penguin Exploits -- Island wakes -- Headland wakes -- Shelves and banks -- Submarine canyons -- Shelfbreak fronts -- Marginal ice zones -- Thermo-/haloclines -- CHAPTER 4. SEA FOOD ̶ THE FISH-BIRD MENU -- General Considerations -- Diet Quality: Survival in Cold Water -- Energy density of prey -- Prey size may or may not differ by penguin size -- Prey availability -- Diet Comparison among Penguin Species -- Polar/subpolar, mesopelagic penguins -- Subpolar, demersal/benthic, continental-shelf penguins -- Temperate, upper water column, continental-insular shelf penguins -- Polar, upper water column, continental shelf/slope penguins -- Subpolar, upper water column, continental slope/pelagic penguins -- Polar, upper water column, continental slope/pelagic penguins -- CHAPTER 5. ECOLOGICAL CONSEQUENCES OF DIET COMPOSITION -- Intraspecific Competition among Penguins -- Foraging Range is Key: General Discussion -- Penguin Species’ Central-Place Foraging Range Patterns -- Sex Differences in Foraging -- Interspecific Competition Involving Penguins -- Penguins Eat A lot! -- Competition between Penguin Species -- Competition between penguins and other seabirds -- Competition between penguins and marine mammals -- Competition between penguins and industrial fisheries -- SECTION III – THE HARDWARE OF A FISH-BIRD -- CHAPTER 6. THE SLIPPERY SHAPE, HOT AIR AND THE POWERHOUSE – HOW FISH-BIRDS SWIM -- Water – Hard Taskmaster -- The Four Forces Relevant to Penguins -- Vertical Forces – Weight and Upthrust -- Buoyancy: How Much Air Do Penguins Hold? -- Buoyancy and Bergmann’s Rule revisited -- Horizontal Forces: Drag -- The Interplay of Drag and Upthrust in Gliding Penguins -- The Drag Devil is in the Detail -- The Penguin Powerhouse -- How Penguins Swim -- The Effect of Upthrust and Body Angle on Penguin Thrust and Lift Forces -- Top Speeds; Power and Upthrust -- The Energy Costs of Swimming -- General considerations -- Specific considerations -- ’Sensible’ Swim Strategies and Costs of Transport -- Cruising speed and integrating speed with the cost of transport, -- and beyond -- CHAPTER 7. HOT PENGUINS ̶ COLD WATER -- Resting and Floating Penguins -- The Metabolic Rate of Floating Penguins -- Patterns of Heat Loss to the Sea -- Overall Body Insulation/Conductance -- The Nature of Penguin Insulation -- Active Penguins -- Activity Produces Heat -- Greater Depths Impose a Higher Heat Tax -- Consuming Prey Imposes a Heat Tax -- Embracing The Fish in the Fish-bird -- CHAPTER 8. FISH-BIRDS – THE INSIDE STORY -- Diving Physiology -- Surface issues – Uptake of oxygen -- Oxygen Management Underwater -- Role of the Air Spaces -- Gas Exchange to Body Tissues -- The Aerobic Dive Limit and Beyond -- The Importance of Size in Dive Performance -- Duration -- Depth -- Penguins Under Pressure – Beating the Squeeze and the Bends -- Barotrauma -- Beating the Bends -- A Gut Reaction in Fish-Birds -- Gastric Emptying -- Rotting Food -- The Eyes Have It -- SECTION IV – THE SOFTWARE OF FISH-BIRDS -- CHAPTER 9. EMBRACING THE DEPTHS - THE PENGUIN DIVE -- Submergence -- The time underwater – basic dive descriptors -- Dive profiles -- Dive distance-depth profiles -- Dive aspect ratios -- Horizontal dive directionality/tortuosity -- The Multifunctionality of Dives -- Basic dive types -- T-dives for travelling -- V-dives (water column assessment) -- P-dives (parabolic – prospecting with no prey capture) -- Po-dives (parabolic dives with circular trajectory) -- U-dives (depth-directed prospecting) -- W-dives/Up-dives (U-dives with prey pursuit) -- Depth Duration Effects Over Multiple Dives -- CHAPTER 10. FISH-BIRD STRATEGIES ̶ THE SEARCH FOR FICKLE PREY -- Decisions, Decisions, Decisions – How Fish-Birds Search for Prey -- Heading in the Right Direction -- Dealing with Prey Patchiness -- In-depth Considerations: -- Time-based efficiency -- Energy-based efficiency -- Superficial Considerations: Surface Pauses and Inspired Tactics -- Being Picky about Food -- Fish-Birds and Smart Strategies -- CHAPTER 11. THE FINAL SECONDS – HOW FISH-BIRDS CAPTURE PREY -- Prey Acquisition, a Departure from the Dive ‘Norm’ -- Performance Metrics for Prey Capture -- Catching Solitary Prey -- Changing buoyancy with depth affects prey capture strategies -- Prey pursuit against interfaces -- Exploiting Aggregated Prey -- Crustaceans -- Fish -- Non-corralling feeding behavior -- Clarity on Limitations of Penguin Vision -- SECTION V – PENGUINS IN A FICKLE ENVIRONMENT -- CHAPTER 12. TURNING THE TABLES – FISH-BIRDS ON THE MENU -- Basic Law of the Sea: Big Fish Eat Little Fish -- Seals as Predators -- Seals’ hunting behavior -- Penguins avoiding seals -- Fur Seals as Predators -- Sea Lions as Predators -- Killer Whales as Predators -- Sharks as Predators -- CHAPTER 13. PENGUINS ADJUSTING TO A CHANGING OCEAN -- Penguins Have Always Been Challenged by a Changing Ocean -- Prehistoric response to a changing ocean -- Possible prehistoric changes to penguins’ food web -- The Anthropocene: How will Penguins Cope, Now Also Dealing with Humans? -- Response to long-term climate change -- Response to short-term ocean climate variation -- Response to marine pollution -- CHAPTER 14. NOT FORGETTING ̶ -- The Social Side - Behavior and Communication at Sea -- Penguin flock fusion/cohesion -- Penguin flock fission/fragmentation -- Navigation -- Long range -- Medium to short-range -- Understanding the Daily ‘Wash’ -- Air flux in diving penguins, an aspect of ‘washing’ -- Are Auks Really ‘Northern Penguins’? -- Research Tags – the Flip Side for Evolutionarily-Honed Fish-Birds -- SECTION VI -- CHAPTER 15. PENGUINS ̶ WHY THE HYPE? -- Sources of Hype -- Us -- Many people -- Researchers -- The Transition -- The fascination of species -- Beyond the transition -- Role in Ecosystems -- Biomimicry -- Our Last Word.
    Abstract: Centuries ago, when penguins were first encountered by European explorers, they were not thought to be birds but rather a fish-like relative. Subsequent accumulation of knowledge has shown penguins to be an avian species with unrivaled aquatic attributes, owing to a number of evolutionary adaptations: shape change, low drag, ability to regulate buoyancy, and extraordinary surface compliancy from their featheration. They are indeed the most extremely specialized diving bird, having given up flight (which otherwise is hugely advantageous) to the benefit of underwater prowess (such as speed, maneuverability and an ability to exploit an extraordinary range of depths). This flightlessness, however, also comes with costs that are substantial for a seabird (such as the inability to cover large distances quickly in reaction to ephemeral prey); and the energy needed to cope with moving through an aqueous environment, which is more resistant than air. For penguins, the high energetic costs in exploiting the ocean environment thus makes them especially sensitive to changes in food availability or their access to their prey. While a number of “penguin books” cover the natural history, mainly of breeding aspects, few address in much detail the incredible aquatic nature of these creatures. A huge amount of information has been amassed over recent past decades thanks to dramatic advances in microelectronics, bio-logging and maturation of some long-term studies of penguin life history. This work represents an integration of all these data with charts, maps and graphs, along with richly illustrated photos by experts in the field. .
    Type of Medium: Online Resource
    Pages: XXII, 567 p. 216 illus., 198 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031339905
    Series Statement: Fascinating Life Sciences,
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Bioclimatology. ; Oceanography. ; Pollution. ; Climatology. ; Freshwater and Marine Ecology. ; Climate Change Ecology. ; Ocean Sciences. ; Pollution. ; Climate Sciences.
    Description / Table of Contents: Part I Climate Change and the Ocean -- 1 Introduction to Climate Change -- 2 Warming, Acidification and Deoxygenation of the Ocean -- 3 Blue Carbon -- 4 Fishes and Carbon -- 5 Whales and Climate -- Part II Fisheries and Food from the Ocean -- 6 State of the World’s Fisheries—Legal Overfishing -- 7 Fish Crimes (Illegal, Unreported, and Unregulated Fishing) -- 8 Aquaculture: Farming Food from the Sea -- 9 Shark Fishing and Shark Finning -- 10 The Move to Sustainable Seafood -- Part III Ocean Pollution -- 11 Plastic and the Ocean -- 12 Shipping and the Ocean -- 13 Oil Spills -- 14 Ocean Noise Pollution -- Part IV Threatened and at Risk Ocean Habitats -- 15 The Deep Sea -- 16 Coral Reefs -- 17 Antarctica and the Southern Ocean: Our Last Great Wilderness -- 18 Top of theWorld—The Arctic Ocean -- 19 Coastal Habitats -- Part V How We Manage the World’s Oceans -- 20 Ocean Governance -- 21 Marine Protected Areas -- 22 Ensuring a Sustainable and Equitable Blue Economy -- 23 Leveraging Innovation for Ocean Conservation -- Part VI Humans and the Ocean -- 24 Oceans and Communities -- 25 Tourism and the Ocean -- 26 The Aquarium Trade -- 27 Marine Animal Welfare: A Growing Concern -- 28 Ocean and Human Health -- Part VII Diversity and Inclusion in the Ocean Space -- 29 Gender and the Ocean: Marine Resources and Spaces for All -- 30 Racial-Gender Disparities, and the Impacts of Coloniality in Ocean Science on BIPOC Women -- 31 Lived Experiences: Editors’ Note -- Part VIII Inspiring Voices -- 32 Inspiring Voices: Inka Cresswell, Jamila Janna, Merrisa Naidoo, Louisa Ponnampalam, Vatosoa Rakotondrazafy, Jo Ruxton MBE, Marilyn Slett, Patima Tungpuchayakul -- Index.
    Abstract: The Ocean and Us provides an overview of our contemporary understanding of the ocean and all the ways our lives interact with it. It is intended for everyone with an interest in our blue planet. The book brings together the expertise of over 35 ocean specialists from around the world. It explores a wide variety of themes including the importance of a healthy ocean in the fight to halt and contain climate change. It covers issues such as overfishing and pollution, as well as emerging themes such as the blue economy, marine animal welfare and how we can leverage innovation to protect the ocean. The book provides an overview of some of the world’s iconic threatened and at risk ocean ecosystems, and outlines current governance structures and ocean management tools. It also discusses the important social dimensions between people and the ocean, such as ocean and human wellbeing, communities and the ocean, and who gets to participate in the ocean space. The book aims to enhance ocean literacy by making specialist concepts accessible to non-experts, with a view to empowering concerned citizens everywhere to come into action for the ocean, and pave a better way forward for humanity.
    Type of Medium: Online Resource
    Pages: XXII, 370 p. 149 illus., 146 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031108129
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Cancer Genetic aspects. ; Cancer Treatment. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1. Breast cancer -- Chapter 1.1. Epidemiology -- Chapter 1.2. Etiology -- Chapter 1.3. Types of breast cancer -- Chapter 1.4. Signs and symptoms -- Chapter 1.5. Stages -- Chapter 1.6. Diagnosis -- Chapter 1.7. Treatment -- Chapter 2. Genetic landscape of breast carcinogenesis -- Chapter 2.1. Hormone receptor positive breast cancer -- Chapter 2.1. Her2 positive breast cancer -- Chapter 2.2. Triple negative breast cancer -- Chapter 3. Epigenetic involvement in breast carcinogenesis -- Chapter 3.1. Histone modification -- Chapter 3.2. DNA methylation -- Chapter 3.3. miRNA -- Chapter 4. Breast cancer control -- Chapter 4.1. Conventional drugs targeting Genetic and Epigenetics in Breast cancer -- Chapter 4.2. Pitfalls of conventional therapy -- Chapter 4.3. Natural remediation -- Chapter 5. Conclusion.
    Abstract: This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment.
    Type of Medium: Online Resource
    Pages: X, 87 p. 13 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811999253
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Bioclimatology. ; Ecology . ; Oceanography. ; Paleontology . ; Freshwater and Marine Ecology. ; Climate Change Ecology. ; Biooceanography. ; Paleontology.
    Description / Table of Contents: INTRODUCTION: THE REEF PHENOMENON -- INTO THE INTIMACY OF CORALS, BUILDERS OF THE SEA -- 1 TAXONOMIC AFFILIATION -- 1.1 Systematic classification of cnidarians -- 1.2 Scleractinians -- 2 MORPHOLOGY AND ANATOMY -- 2.1 Polyp anatomy -- 2.2 Reproduction -- 2.2.1 Sexual reproduction -- 2.2.2 Asexual reproduction -- 2.3 Anatomy of calcareous skeletons -- 2.4 Coral colonies -- 2.4.1 Corallite arrangement -- 2.4.2 Colony morphology -- 3 SYMBIOSIS -- 4 BIOMINERALIZATION -- 4.1 Calicoderm and biomineralization -- 4.2 Skeletons and biomineralization -- 4.3 Interface between calicoderm and skeleton -- 4.4 Principles of calcification -- 5 NUTRITION -- 5.1 Prey capture -- 5.2 Food -- 5.3 Autotrophy -- THE MODERN TIMES -- 1 BIOZONATION -- 2 REEF MORPHOTYPES -- 2.1 Fringing reefs -- 2.2 Barrier reefs -- 2.3 Atolls -- 2.4 Bank reefs -- 2.5 High carbonate islands -- 3 GEOGRAPHICAL DISTRIBUTION -- 3.1 Ecological control -- 3.2 Tectonic control -- 3.3 Eustatic control -- 3.4 Topographic control -- 4 REEF GROWTH -- 4.1 Vertical growth strategies -- 4.1.1 Controlling factors -- 4.1.2 Give-up growth -- 4.1.3 Keep-up growth -- 4.1.4 Catch-up mode -- 4.2 Lateral growth -- 5 MORPHO-SEDIMENTARY PROCESSES -- 5.1 Bioconstruction -- 5.2 Erosion -- 5.3 Bioaccumulation -- 5.4 Cementation -- 6 INTERNAL STRUCTURE -- 6.1 Nature and distribution of facies -- 6.1.1 Framework facies -- 6.1.2 Detrital facies -- 6.1.3 Facies distribution and hydrodynamics -- 6.2 The different structural models -- 7 A BRIEF HISTORY OF REEF DEVELOPMENT -- 7.1 The climatic context -- 7.2 History of reef development since the last deglaciation -- 7.3 Reef history throughout the Pleistocene -- 8 RECORD OF ENVIRONMENTAL CHANGES -- 8.1 Record at the coral colony scale -- 8.1.1 Temperature -- 8.1.2 Salinometry -- 8.1.3 Rainfall -- 8.1.4 pH measurement -- 8.1.5 Photometry -- 8.1.6 Current measurement -- 8.2 Record at the scale of a reef edifice -- 8.2.1 Reef flats and micro-atolls -- 8.2.2 Arrangement of coral communities -- 8.2.3 Arrangement of reef edifices -- THE LONG MARCH OF CORALS -- 1 THE TIME OF THE ORIGINS -- 1.1 Early Earth and the first traces of life -- 1.2 Evolution of the atmosphere -- 1.3 Geochemical model of the early ocean -- 1.4 Emergence of biomineralization -- 1.5 The early calcifying organisms and cnidarians -- 1.6 The earliest corals -- 1.7 The appearance of scleractinian corals -- 2 THE TIME OF DIVERSIFICATION -- 2.1 Coral-algae symbiosis -- 2.1.1 Acquiring photosymbiosis -- 2.1.2 Evidence of photosymbiosis -- 2.1.3 Symbiosis and coloniality -- 2.2 A brief history of coral and reef building -- 2.2.1 Paleozoic times -- 2.2.2 Mesozoic times -- 2.2.3 Cenozoic times -- THE HIGHS AND LOWS OF THE REEF PHENOMENON -- 1 CAUSES -- 1.1 Causal relationships -- 1.2 Gas emissions and volcanic products -- 1.3 Methane emissions -- 1.4 Thermogenic gases -- 1.5 The fall of celestial bodies -- 1.6 Behaviour of organisms facing environmental disturbances -- 1.7 Disturbances induced by CO2 and ocean acidification -- 1.8 Thermal shocks -- 1.9 Disturbances induced by ocean deoxygenation -- 2 THE MAIN BIOLOGICAL CRISES -- 2.1 The Cambrian crises -- 2.2 The major crisis of the Ordovician end -- 2.3 The minor crises of the Silurian -- 2.4 The successive crises of the Devonian -- 2.5 The Permian crises -- 2.6 The Triassic crises -- 2.7 The lower Jurassic crisis -- 2.8 The Jurassic–Cretaceous transition (J–K) -- 2.9 The Cretaceous–Paleogene crisis -- 2.10 The Paleocene–Eocene crisis -- 2.11 The Eocene–Oligocene transition -- 2.12 The Oligocene end to the Plio-Quaternary -- 3 THE RESPONSE OF CORALS AND REEFS TO CRISES: FROM EXTINCTION TO RECOVERY -- 3.1 At the Ordovician end -- 3.2 During the Silurian -- 3.3 During the Devonian -- 3.4 At the Permian -- 3.5 At the Permian–Triassic boundary -- 3.6 From the middle to the end of the Triassic -- 3.7 During the Jurassic -- 3.8 From the upper Jurassic to the lower Cretaceous -- 3.9 At the Cretaceous–Paleogene (K–Pg) transition -- 3.10 From the Paleocene to the Eocene -- 3.11 From the Oligocene to the Miocene -- 3.12 During the Plio-Quaternary -- 4 CONCLUSIONS -- CORAL REEFS IN THE FACE OF THEIR FATE -- 1 DISRUPTIVE AGENTS IN ACTION -- 1.1 Carbon dioxide and rising surface water temperatures -- 1.2 Carbon dioxide and its effects on the carbonate cycle -- 1.3 Carbon dioxide and ocean acidification -- 1.4 The other disruptive agents -- 2 THE RESPONSE OF CORALS AND CORAL REEFS -- 2.1 Temperature rise of surface waters -- 2.2 To acidification -- 2.3 To other disruptive agents -- 3 THE EVOLUTION OF CORAL ISLETS -- 3.1 The modes of low-lying island formation -- 3.2 Future evolution of low-lying islands: maintenance, reduction, or destruction? -- CONCLUSIONS -- BIBLIOGRAPHY -- INDICE.
    Abstract: The health status and future of tropical coral reefs, as tourist destinations, are regularly subjected to media coverage. Many documentaries recognize the natural beauty and biological richness of the Australian Great Barrier Reef and French Polynesian lagoons, but point to the equally significant risk that would result from current global warming and human-made hazards. The future of coral reefs is usually a matter of death foretold, real or purely imaginary. In this context, it has become necessary to differentiate between what is falling within reality of scientific facts or fantasy. To this end, the present general review, in the expert translation of Charlotte Fontan aims at: (1) defining the conditions and life requirements of reefbuilding corals; (2) the history of corals along with that of a number of associated, skeletal organisms involved in reef building since the very beginning, i.e. the last 540 million years, including the ups and downs they have experienced; (3) giving special reference to the development patterns of recent and modern reefs; (4) projecting corals and reefs into a still unknown future. Understanding how corals and reefs have originated, how they have been able to face the major biological crises which have punctuated the Earth’s history, how they have survived is a prerequisite to better gain a significant picture of their future.
    Type of Medium: Online Resource
    Pages: IX, 166 p. 120 illus., 117 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031168871
    Series Statement: Coral Reefs of the World, 16
    DDC: 577.6
    Language: English
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  • 32
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Stem cells. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Stem Cells. ; Cancer Therapy. ; Cancer Biology. ; Cancer Genetics and Genomics.
    Description / Table of Contents: 1. Introduction and perspective in carcinogenesis -- 2. Origin and Development of Cancer Stem Cells -- 3. Detection and Isolation of Cancer Stem Cells -- 4. The genetic and epigenetic landscape of cancer stem cells -- 5. Metabolism of Cancer Stem Cell -- 6. Plasticity of Cancer Stem Cell -- 7. Cancer Stem Cells in Cancer Initiation and Progression -- 8. Cancer Stem Cells and Metastasis -- 9. Roles of Cancer Stem Cells in Therapy resistance and Disease Recurrence -- 10. Novel therapeutics targeting cancer stem cell surface markers -- 11. Therapeutics targeting cancer stem cells signalling pathways -- 12. Cancer stem cells therapeutics delivery and EPR effect -- 13. Immunotherapy against cancer stem cells -- 14. Engineering nanobody targeting cancer stem cells -- 15. Biological barriers for drug delivery to cancer stem cells -- 16. Cancer Stem Cell Markers in Haematological Malignancies -- 17. Diagnostic and Prognostic Significance of Cancer Stem Cells Surface Markers -- 18. Diagnostic and prognostic implications of cancer stem cells transcription factors -- 19. Diagnostic and prognostic significance of intracellular markers of CSCs in patients with cancers. .
    Abstract: This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.
    Type of Medium: Online Resource
    Pages: XVI, 372 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819931859
    DDC: 571.978
    Language: English
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  • 33
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Invertebrates. ; Ecology . ; Oceanography. ; Freshwater and Marine Ecology. ; Biodiversity. ; Invertebrate Zoology. ; Biooceanography.
    Description / Table of Contents: Chapter 1. The Shrimps: An Overview -- Chapter 2. Structure and Function -- Chapter 3. The Families of Decapod Shrimps -- Chapter 4. Shrimp Hygiene: Antifouling Adaptations -- Chapter 5. Coloration, Color Change and Camouflage -- Chapter 6. Reproduction -- Chapter 7. Sexual Systems -- Chapter 8. Mating Systems -- Chapter 9. Life Histories -- Chapter 10. Symbioses -- Chapter 11. Fisheries and Aquaculture -- Chapter 12. Evolutionary History and Relationships of Shrimps.
    Abstract: This book explores the biology of decapod shrimps, a group of animals known to most people as a nutritious and tasty food item. Shrimps are amazingly diverse in size, shape, coloration, behavior and natural history. Shrimp fisheries and aquaculture are a vital part of the USA and world economies. These crustaceans are key ecological and food-web components of marine and freshwater habitats. The book synthesizes information on the taxonomic and ecological diversity of shrimps, the structure and function of shrimp anatomy, antifouling adaptations, coloration and camouflage, reproductive biology, sexual systems, mating systems and behavior, life history strategies, symbioses between shrimps and other organisms, shrimp fisheries and aquaculture, as well as the evolution and phylogeny of shrimps. All chapters are written within an adaptational and evolutionary perspective. Important questions about shrimp biology are asked, and hypotheses for testing in future research are proposed. The book is spiced up with personal anecdotes and observations from the author’s research experiences. This book is intended as a comprehensive reference, a “go to” book about the biology of shrimps. The text is scientifically rigorous but written in a style intended for a varied readership. Thus, the book is a valuable resource for budding or working research scientists such as zoologists, aquatic biologists, fisheries and aquaculture professionals, as well as amateur naturalists, aquarium hobbyists and interested laypersons. As the saying goes, “a picture is worth a thousand words,” so that the book is amply illustrated with figures and diagrams.The numerous color plates, composed of photos contributed by expert colleagues, make the world of shrimps come alive.
    Type of Medium: Online Resource
    Pages: XIX, 720 p. 239 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031209666
    Series Statement: Fish & Fisheries Series, 42
    DDC: 577.6
    Language: English
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  • 34
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Environmental chemistry. ; Pollution. ; Toxicology. ; Freshwater and Marine Ecology. ; Environmental Chemistry. ; Pollution. ; Toxicology.
    Description / Table of Contents: Part I. Introduction -- An Introduction to Reservoir Ecotoxicology -- Part II. Environmental Characteristics in Reservoir Ecosystems -- Characterization of Reservoir Ecosystem -- Main Sources and Distribution of Pollutants in the Reservoir -- Migration and Transformation of Pollutants in the Reservoir -- Harmful Algal Bloom in the Reservoir -- Microplastics Pollution in the Reservoir: Occurrence, Extraction, and Characterization -- Distribution of Microorganisms in the Reservoir -- Part III. Study Methods of Ecotoxicology in the Reservoir -- Ecotoxicity Test Methods of Primary Producers in the Reservoir -- Ecotoxicology Methods of Reservoir Water Using Invertebrates -- Ecotoxicology Methods of Reservoir Water Using Fish -- Ecotoxicology Methodology of Sediment Toxicity in the Reservoir -- Mesocosm Study in the Reservoir Ecosystem -- Part IV. Ecotoxicological Effects and Mechanism of Pollutants in the Reservoir -- Molecular Toxicity Mechanism of Heavy Metals in the Reservoir -- Molecular Toxicity Mechanism of Persistent Organic Pollutants (Pops) in the Reservoir -- Molecular Toxicity Mechanism of Microplastics in the Reservoir -- Molecular Toxicity Mechanism of Plasticizers in the Reservoir -- Molecular Toxicity Mechanism of PPCPs in the Reservoir -- Adverse Outcome Pathways (AOPs) of Pollutants in the Reservoir -- Invasive Alien Species Problem in the Reservoir -- Part V. Conclusions -- Final Thoughts and Concluding Remarks.
    Abstract: Reservoir construction is the key strategy for water resource management. In recent years, the migration of pollutants and their transformation into the reservoir ecosystem has become a global problem. Intensified anthropogenic activities and unsustainable practices have amplified the pollutant levels in the reservoir. Therefore, this book intends to highlight environmental characteristics of the reservoir, study methods of ecotoxicology, and mechanistic toxicogenetic pathways of pollutants in the reservoir. Adverse outcome pathway (AOPs) model is used to elucidate toxicological effects of reservoir pollutants. Moreover, ecological and human health risks of the Three Gorges Reservoir (TGR), the largest power generation reservoir on earth, and its pollution status are also discussed.
    Type of Medium: Online Resource
    Pages: XXXI, 234 p. 31 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031263446
    DDC: 577.6
    Language: English
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  • 35
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Zoology. ; Ecology . ; Oceanography. ; Bioclimatology. ; Environment. ; Freshwater and Marine Ecology. ; Biodiversity. ; Zoology. ; Biooceanography. ; Climate Change Ecology. ; Environmental Sciences.
    Description / Table of Contents: Chapter 1. Introduction: The Relevance of Anthropogenic Factors to Coral Reef Conservation in the Coastal Areas of the East China Sea -- Chapter 2. Transitional Coral Ecosystem of Taiwan in the Era of Changing Climate -- Chapter 3. Dynamics of Coral Reef Communities in the Sekisei Lagoon, Japan, Following the Severe Mass Bleaching Event of 2016 -- Chapter 4. Succession and Emergence of Corals in High-Latitude (Temperate) Areas of Eastern Asia into the Future -- Chapter 5. Succession and Spread of Coral Diseases and Coral-Killing Sponges with Special Reference to Microbes in Southeast Asia and Adjacent Waters -- Chapter 6. Succession of Ocean Acidification and its Effects on Reef-Building Corals -- Chapter 7. Anthropogenic Stresses in Coral Reefs and Adjacent Ecosystems of the East China Sea -- Chapter 8. Development of a Compact Experimental System for Ecotoxicological Experiments on Acropora spp. -- Chapter 9. Effects of Anthropogenic Chemicals on Hermatypic Corals with Special Reference to Gene Expression -- Chapter 10. Perspective for the Conservation of Coral Reefs in the East China Sea.
    Abstract: Coral reefs, which are one of the most productive and biodiverse ecosystems on Earth, serve various important roles, such as providing shelter and spawning grounds to a wide range of marine animals. However, the global decline of hard corals in tropical and subtropical regions is a growing concern. A recent review of the Intergovernmental Panel on Climate Change (IPCC) indicated that only 10%–30% of coral reefs would survive with an increase of 1.5 °C in global warming temperature. Of coral reefs around the world, the coral reefs in eastern Asia face one of the most industrially developed and high population areas in the world. Thus, coral reefs of eastern Asia have been affected by various anthropogenic factors, such as eutrophication, coastal development, anthropogenic pollutants, ocean acidification, disease, and overfishing. Therefore, urgent research is required to determine the levels at which different factors will affect coral health. Besides, we propose a perspective on coral reef (especially those in eastern Asia) conservation under climate change and various anthropogenic activities.
    Type of Medium: Online Resource
    Pages: VII, 180 p. 87 illus., 82 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031275609
    Series Statement: Coral Reefs of the World, 17
    DDC: 577.6
    Language: English
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  • 36
    Keywords: Freshwater ecology. ; Marine ecology. ; Animal culture. ; Vertebrates. ; Sexual selection. ; Freshwater and Marine Ecology. ; Animal Science. ; Vertebrate Zoology. ; Sexual Selection.
    Description / Table of Contents: Chapter 1. Sex and Behavior -- Chapter 2. Genetic Tools to Investigate the Consequences of Sex -- Chapter 3. Skulls, Teeth, and Sex -- Chapter 4. Cetacean Evolution: Copulatory and Birthing Consequences of Pelvic and Hindlimb Reduction -- Chapter 5. Sexual Anatomy of Female Cetaceans: Art and Science Contribute Insights into Functionality -- Chapter 6. Interspecific Comparison of Reproductive Strategies -- Chapter 7. Non-Conceptive Sexual Behavior in Cetaceans: Comparison of Form and Function -- Chapter 8. Play, Sexual Display, or Just Boredom Relief? -- Chapter 9. Sexual Behaviors of Odontocetes in Managed Care -- Chapter 10. Infanticide and Sexual Conflict in Cetaceans -- Chapter 11. Drone Perspectives on Cetacean Mating and Sex -- Chapter 12. Inter- and Intrapopulation Variation in Bottlenose Dolphin Mating Strategies -- Chapter 13. Sex and Sexual Strategies in Deep-Diving Risso's Dolphins -- Chapter 14. Sociosexual Behavior of Nocturnally Foraging Dusky and Spinner Dolphins -- Chapter 15. Life History Parameters, Sociobiology, and Reproductive Strategies of Pilot Whales -- Chapter 16. Sex in Killer Whales: Behavior, Exogamy and the Evolution of Sexual Strategies in the Ocean’s Apex Predator -- Chapter 17. Beaked Whale Sexual Dimorphism, Mating Strategies, and Diversification -- Chapter 18. Sexual Behavior and Anatomy in Porpoises -- Chapter 19. Sperm Whale Reproductive Strategies: Current Knowledge and Future Directions -- Chapter 20. Reproductive Tactics in Baleen Whales -- Chapter 21. Gray Whale Sex, Reproductive Behavior, and Social Strategies -- Chapter 22. Bowhead Whale Reproductive Strategies -- Chapter 23. Right Whale Sexual Strategies and Behavior -- Chapter 24. Cetacean Sociality, Reproduction, and Conservation.
    Abstract: Sex in Cetaceans provides an up-to-date review of multi-faceted aspects related to mating and reproduction in toothed and baleen whales. This open access book begins with discussions of sexual selection and anatomical traits related to mating and diversity between the sexes. The functions of non-conceptive copulations are reviewed as are different research techniques applied to explore sex in cetaceans. Authors and editors build knowledge of female and male social, mating, and parental strategies and tactics for several specific toothed dolphin/porpoise/whale species and baleen whale species. It concludes with a discussion of potential conservation efforts and ways to help especially beleaguered species and populations the world over. The volume is intended as a major primer of cetacean sex for undergraduate and graduate students, new and established researchers in the field, and the public wishing to learn more.
    Type of Medium: Online Resource
    Pages: IX, 619 p. 123 illus., 112 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031356513
    DDC: 577.6
    Language: English
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  • 37
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Tumors Immunological aspects. ; Therapeutics. ; Cancers. ; Tumour Immunology. ; Therapeutics.
    Description / Table of Contents: Chapter 1_Introduction to Cancer -- Chapter 2_Expression pattern of Chemokines in Cancer -- Chapter 3_Implications of Cytokine-Chemokine Heterogenity in Cancer -- Chapter 4_Cytokine and chemokines networks in cancer stemness -- Chapter 5_Cytokine and chemokines networks in angiogeneis -- Chapter 6_Role of Cytokine-Chemokine cascades in Epithelial to Mesenchymal Transition -- Chapter 7_Role of Chemokines in establishment of Metastatic Niche -- Chapter 8_CXCL12-CXCR4 axis in Metastasis -- Chapter 9_Chemokine and cytokine networks in the tumor microenvironment -- Chapter 10_CXCL9, CXCL10, CXCL11/CXCR3 axis and Immune Activation -- Chapter 11_CXCL8-CXCR1/2 axis in cancer and inflammatory diseases -- Chapter 12_Cytokine and Chemokine Networks in Therapeutic Resistance -- Chapter 13_Prognostic and diagnostic significance of Chemokines and cytokines in cancer -- Chapter 14_Therapeutic implications of Chemokines and cytokines networks in cancer -- Chapter 15_Chemokines in cancer therapy.
    Abstract: Cytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.
    Type of Medium: Online Resource
    Pages: XVII, 440 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819946570
    DDC: 571.978
    Language: English
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  • 38
    Keywords: Freshwater ecology. ; Marine ecology. ; Microbiology. ; Microbial ecology. ; Microbial populations. ; Freshwater and Marine Ecology. ; Microbiology. ; Environmental Microbiology. ; Microbial Communities.
    Description / Table of Contents: Chapter 1. Freshwater microbiology: recent updates and prospects -- Chapter 2. The Chemical Composition of the Water in the Rivers, Lakes, and Wetlands of Uttarakhand -- Chapter 3. Microbial diversity of cold-water reservoirs and their prospective applications -- Chapter 4. Overview of microbial associations and their role under aquatic ecosystems -- Chapter 5. Plant-microbe interaction in Freshwater ecosystem for improving water quality -- Chapter 6. Microbial interactions with aquatic plants -- Chapter 7. Status of Microplastic pollution in the freshwater ecosystems -- Chapter 8. Heavy metal pollution in water: Cause and remediation strategies -- Chapter 9. Recent advances in biological wastewater treatment -- Chapter 10. Recent developments in wastewater treatments -- Chapter 11. Wastewater treatment: perspective and advancements -- Chapter 12. Overview of methods and processes used in waste water treatment -- Chapter 13. Role of microorganisms in polluted water treatment -- Chapter 14. Bioremediation of Polluted water -- Chapter 15. Pollution in freshwater: Impact and Prevention -- Chapter 16. Fresh water pollution: overview, prevention and control -- Chapter 17. Iron Degrading Bacteria in the Aquatic Environment: Current Trends and Future Directions -- Chapter 18. Bioactive compounds from aquatic ecosystem -- Chapter 19. Freshwater BGA: A potential candidate for sustainable agriculture and environment for the welfare of future planet earth -- Chapter 20. Factors affecting Fish migration.
    Abstract: This contributed volume deals with the various aspects of freshwater microbiology including diverse habitats, associated microorganisms, their ecological interactions, and industrial applications. Freshwater ecosystems are dynamic natural resources, providing sources of potable water, food, animal habitats, and recreation. Perspectives of microbial dynamics in freshwater bodies, covered in this title, provide a comprehensive and systematic analysis of microbial ecology in these ecosystems. These microbes are at the hub of biogeochemical cycles (carbon, nitrogen, phosphorus, potassium, and other elements). Moreover, they are an integral part of the aquatic food web and control the quality of freshwater bodies. Chapters in this title also discuss the issue of pollution in freshwater bodies and put forward available strategies for eco-friendly solutions. The book is a perfect documentation of primary and secondary data-based information on the latest research findings, case studies, experiences, and innovations in the field of freshwater microbiology. The book is of great use to students, researchers, and professionals studying aquatic sciences.
    Type of Medium: Online Resource
    Pages: XV, 437 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819950188
    DDC: 577.6
    Language: English
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  • 39
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Restoration Ecology. ; Riparian Ecology. ; Environmental management. ; Conservation biology. ; Ecology . ; Freshwater and Marine Ecology. ; Restoration Ecology. ; Riparian Ecology. ; Environmental Management. ; Conservation Biology.
    Description / Table of Contents: Chapter 1. Introduction to Wetlands -- Chapter 2. The Causal Factor Approach to Wetland Ecology -- Chapter 3. Duration of Flooding is the Most Important Causal Factor -- Chapter 4. Flood Pulses -- Chapter 5. Fertility -- Chapter 6. Natural Disturbance -- Chapter 7. Competition -- Chapter 8. Herbivory -- Chapter 9. Burial -- Chapter 10. Salinity -- Chapter 11. Roads -- Chapter 12. Coarse Woody Debris -- Chapter 13. Invasive Species are an Emerging Causal Factor -- Chapter 14. Human Population Size -- Chapter 15. The Global Context for Wetland Protection and Restoration -- Chapter 16. Some Review Questions for Managers.
    Abstract: This book presents 12 effective methods to manage wetlands for conservation. It offers a tool box of causal factors that can be used to protect and restore wetlands to enhance biological diversity and other functions. Each causal factor is introduced, briefly explained, and then illuminated with selected examples from around the world. The book provides a prioritized shopping list of methods for protecting and restoring wetlands. The three first and most important causal factors are flooding, fertility, and natural disturbance. Then nine other causal factors are introduced, including herbivory, sedimentation, roads, invasive species, and coarse woody debris. Each causal factor is carefully linked to the scientific literature and explained using the author’s own experience. The same list of 12 causal factors applies around the world—whether you are managing a temperate zone floodplain, a tropical peatland, a freshwater marsh, or a coastal mangrove swamp. Instead of hiring an expensive team of consultants, or pouring through hundreds of scientific papers, here is one concise guide to methods that can be immediately applied to benefit any wetland. Professor Paul Keddy has spent more than 50 years studying wetlands, and writing and lecturing about the environmental factors that control them. He has published more than 150 scholarly papers, and won multiple scientific prizes. His book Wetland Ecology is widely used to teach the principles of wetland science. Causal Factors for Wetland Management: A Concise Guide has a much simpler message: how to protect and enhance wetlands. In this concise guide, he has condensed a lifetime of experience into just 12 principles. The book is aimed at all people who protect or restore wetlands: park managers, wildlife biologists, landscape architects, engineers, environmental consultants, environmental agencies, conservation authorities, and NGOs—as well as landowners and concerned citizens. Causal Factors for Wetland Management: A Concise Guide is essential reading for anyone who cares for wetlands and wild places.
    Type of Medium: Online Resource
    Pages: XIII, 158 p. 80 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031217883
    Series Statement: Wetlands: Ecology, Conservation and Management, 8
    DDC: 577.6
    Language: English
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  • 40
    Keywords: Freshwater ecology. ; Marine ecology. ; Microbiology. ; Agriculture. ; Freshwater and Marine Ecology. ; Microbiology. ; Agriculture.
    Description / Table of Contents: Section 1: General considerations -- Chapter 1. Physical and chemical processes of marine environment -- Chapter 2. A review study on the microbes in the recycling of carbon -- Chapter 3. Microbial symbiosis in marine ecosystem -- Section 2: Communities of special interest -- Chapter 4. Cyanobacteria in oceanChapter -- Chapter 5. Marine algae and their importance -- Chapter 6. Antarctica microbial communities: ecological and industrial importance -- Chapter 7. Crustaceans - microbes and defense mechanisms -- Section 3: Marine microorganisms and environmental bioremediation -- Chapter 8. Pollution in marine ecosystem: impact and prevention -- Chapter 9. Source and effect of oil spills on associated microorganisms in marine aquatic environment -- Chapter 10. Heavy metal pollution in water: cause and remediation strategies -- Chapter 11. Responses of marine fungi to heavy metal contamination -- Chapter 12. Micro-plastic pollution in marine ecosystem and its remediation -- Chapter 13. Microplastic pollution in aquatic environment: ecotoxicological effects and bioremediation prospects -- Chapter 14. Biodegradation of endocrine-disrupting chemicals using marine microorganisms -- Chapter 15. Bioreactors for bioremediation of polluted water -- Section 4: Others applications and perspectives -- Chapter 16. Industrial importance of marine algae -- Chapter 17. Sargassum derived agents for potential cosmetic applications -- Chapter 18. Utilization of seaweed as partial replacement to the fish meal in aquaculture diets -- Chapter 19. Nanobiotechnology of marine organisms: mechanisms and applications -- Chapter 20. Bioactive compounds from marine water ecosystem -- Chapter 21. Marine fish microbiome: current status and future perspectives.
    Abstract: This contributed volume focuses on the latest innovations in the field of marine microbiology. Marine ecosystems are dynamic natural resources and home to very primitive life forms. They include open sea, deep sea, coastal marine ecosystem mudflats, seagrass meadows, mangroves, and rocky intertidal systems. This book deals with the various aspects of marine microbiology including diverse habitats, associated microorganisms, their adaptations, ecological interactions, biogeochemical cycling, and industrial applications. It also discusses the issue of pollution in oceans and put forward available strategies for its eco-friendly solution. In recent years, extensive research, advanced methodologies, and high-throughput instrumentation have resulted in voluminous data and information that require proper compilation and worldwide sharing. From this perspective, the book is a perfect documentation of primary and secondary data-based information on the latest research findings, case studies, experiences, and innovations in the field of marine microbiology. The book is of great use to students, researchers and professionals studying marine sciences.
    Type of Medium: Online Resource
    Pages: XVII, 480 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819950225
    DDC: 577.6
    Language: English
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  • 41
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Freshwater ecology. ; Marine ecology. ; Animal culture. ; Water. ; Hydrology. ; Sustainability. ; Conservation biology. ; Ecology . ; Freshwater and Marine Ecology. ; Animal Science. ; Water. ; Sustainability. ; Conservation Biology.
    Description / Table of Contents: Chapter 1. Morphology and Taxonomy -- Chapter 2. Population Structure and Speciation -- Chapter 3. Life History -- Chapter 4. Spawning Areas -- Chapter 5. Larval Transport -- Chapter 6. Glass Eel Recruitment -- Chapter 7. Spawning Migration -- Chapter 8. Behavior -- Chapter 9. Nervous Systems and Sense -- Chapter 10. Digestion and Absorption -- Chapter 11. Osmoregulation -- Chapter 12. Reproduction -- Chapter 13. Metamorphosis and Silvering -- Chapter 14. Artificial Maturation -- Chapter 15. Larval Rearing -- Chapter 16. Breeding -- Chapter 17. Disease -- Chapter 18. Fisheries -- Chapter 19. Resources -- Chapter 20. Trading -- Chapter 21. Distribution -- Chapter 22. River Improvement -- Chapter 23. Conservation. .
    Abstract: This book is a compilation of eel research and fish migration studies for more than 40 years showing the research history and recent advances in eel studies. Dr. Katsumi Tsukamoto, the esteemed editor of this book, has been actively involved in eel research as one of the leading scientists in the world for a long time, and he and his team successfully collected the fertilized eggs and spawn-condition adult eels from the wild for the first time in the world. This book compiles the essentials of the scientific findings obtained by the editor and his colleagues and reviews the latest references of eel science. Knowledge and information in the book such as a spawning area survey, research on artificial production of glass eels, the discovery of a new species, etc. will attract the reader’s interest, as these are written based on the authors’ experiences. Readers can obtain a comprehensive understanding of eels from various aspects of eel science including the cultural and socio-economic importance of eels and valuable scientific information using state-of-the-art approaches. The book also endeavors to contribute to the conservation of eel species, some of which have been classified as endangered by the IUCN and to promoting harmonious coexistence between humans and nature.
    Type of Medium: Online Resource
    Pages: VIII, 318 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819956920
    Series Statement: Fisheries Science Series,
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Animal biotechnology. ; Freshwater and Marine Ecology. ; Biodiversity. ; Animal Biotechnology.
    Description / Table of Contents: Preface -- About the Authors -- Chapter 1 Biotechnology in Fisheries -- Chapter 2 Nucleic Acids -- Chapter 3 Gene and Genetic Code -- Chapter 4 Mutations and their Implications -- Chapter 5 Gene Regulation and Expression in Prokaryotes -- Chapter 6 Gene Regulation and Expression in Eukaryotes -- Chapter 7 Epigenetics -- Chapter 8 RNA in Gene Regulation -- Chapter 9 Recombinant DNA Technology -- Chapter 10 Transgenic Fish Production -- Chapter 11 Animal Cell Culture -- Chapter 12 Hybridoma Technology -- Chapter 13 Cryopreservation Technology in Fishes -- Chapter 14 Molecular Techniques -- Chapter 15 Molecular Markers -- Chapter 16 Biosensors -- Chapter 17 Bioremediation -- Chapter 18 Bioprocess Engineering in Fisheries -- Chapter 19 Bioprospecting in Fisheries -- Chapter 20 Bioinformatics- Databases and Formats -- Chapter 21 Sequence Retrieval, Manipulation, Analysis -- Chapter 22 Bioinformatic Tools and Techniques -- Chapter 23 Genomics and its Application in Fisheries.
    Abstract: This authored book is focused on SDG 14: Life below water, comprehensively addressing all facets of biotechnology and bioinformatics related to fisheries. It offers an extensive exploration of the detail on structure, function and types of nucleic acids, concepts of gene and genetic code, mutations, and their implications. The book provides essential information on gene regulation and expression in prokaryotes and eukaryotes. Step-by-step descriptions are provided for technologies such as gene transfer, rDNA, transgenic fish production, animal cell culture, hybridoma technology and cryopreservation technology in fishes. Special emphasis has been given to topics like RNA in gene regulation, epigenetics, and DNA and protein sequencing. Various molecular techniques and markers have been discussed in detail. Further, various topics on bioinformatics including different databases, formats, sequence retrieval, manipulation, analysis, primer design, molecular visualization, genomics, and proteomics are also covered. This volume will prove invaluable to aquaculturists, equipping them with essential techniques and protocols. It constitutes essential reading for students enrolled in aquaculture or fisheries courses within tropical and sub-tropical regions.
    Type of Medium: Online Resource
    Pages: XV, 220 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819969913
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Metabolism. ; Cancer Treatment. ; Biochemistry. ; Oxidation-reduction reaction. ; Cancer Metabolism. ; Cancer Therapy. ; Redox Biology.
    Description / Table of Contents: 1. ROS, redox regulation and signaling in cancer cells -- 2. ROS and redox regulation/signaling and metabolism in cancer stem cells -- 3. . ROS/Redox regulation with dietary phytochemicals and role in anticancer activity -- 4. ROS/Redox signaling and apoptosis/necroptosis/autophagy in cancer -- 5. Cancer Metastasis, ROS/redox signaling and PCD resistance/redox metabolism -- 6. Immune system, redox signaling and cancer immunity -- 7. P53, ROS- redox regulation signaling, metabolic reprogramming and autophagy in cancer -- 8. Cell cycle, DNA damage-repair systems and impact of redox regulation in cancer -- 9. ROS, redox regulation and anticancer therapy -- 10. Perspectives in ROS/redox regulation cancer therapy.
    Abstract: This book aims to provide an association of the major redox-sensitive pathways and networks involved in cancer. The initial chapter of the book discusses basic information about oxidative stress, its generation, and regulation (redox regulation or redox homeostasis) via cell signaling in normal and cancer cells. The book also explores antioxidants and metabolic events in cancer cells compared to normal cells. It further covers the application of nanoparticles in redox regulation in cancer cells. The role of redox regulation in cancer therapy, its influence, and its involvement in programmed cell death (PCD), metastasis, immune system, p53, and cell cycle/DNA damage repair pathways have been discussed in separate chapters. It further reviews the importance of dietary phytochemicals in redox regulation in normal and cancer pathophysiology. Towards the end, the book focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells.
    Type of Medium: Online Resource
    Pages: XI, 431 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819973422
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Oceanography. ; Agriculture. ; Environmental sciences Social aspects. ; Water. ; Hydrology. ; Freshwater and Marine Ecology. ; Ocean Sciences. ; Agriculture. ; Environmental Social Sciences. ; Water.
    Description / Table of Contents: Chapter 1: Tilapia Fish For Future Sustainable Aquaculture -- Chapter 2: Health Management For Sustainable Tilapia Farming -- Chapter 3: Effects Of Feed Additives On Tilapia Reproduction -- Chapter 4: Intestinal Microbiota Of Tilapia: Characterization And Modulation -- Chapter 5: Probiotics And Their Application In Tilapia Culture -- Chapter 6: Prebiotics And Synbiotics In Nile Tilapia Culture -- Chapter 7: Medicinal Plants In Tilapia Aquaculture -- Chapter 8: Alternative Protein Sources For Sustainable Tilapia Farming -- Chapter 9: Sustainable Tilapia Farming, The Role Of Culture Systems.
    Abstract: The global human population will reach nine billion by 2050, and seafood is projected to be the primary food source to sustain such a large population. According to a recent World Bank report, aquaculture will be the prime source of seafood by 2030. Tilapia is one of the promising species for commercial aquaculture and one of the second most farmed fish worldwide. Given the issues raised by Antibiotic misuse in intensive aquaculture, such as the occurrence of resistant bacteria, it is necessary to develop environment-friendly strategies that could be used to improve production in a sustainable manner. Also, there is a need to establish the best aquaculture practice (BAP) approaches to avoid significant disruption to the ecosystem, the loss of biodiversity, and substantial pollution impact on the environment. We believe the current book will be very helpful to academics, researchers, and policy-makers in aquaculture. .
    Type of Medium: Online Resource
    Pages: XVI, 262 p. 6 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031383212
    Series Statement: Applied Environmental Science and Engineering for a Sustainable Future,
    DDC: 577.6
    Language: English
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    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Geography. ; Environment. ; Power resources. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Regional Geography. ; Environmental Sciences. ; Natural Resource and Energy Economics.
    Description / Table of Contents: Intro: Navigating Patagonian freshwaters- and this book -- 1: Are freshwaters wetlands? -- 2: Patagonian Andean lakes and climate change -- 3: Current state and recent changes of glaciers in the Patagonian Andes (35 °S to 55°S) -- 4: Biogeographical patterns of Patagonian freshwater microbiota -- 5: Extreme freshwater ecosystems from Patagonia: The Copahue-Agrio system -- 6: Mercury in aquatic systems of North Patagonia: sources, processes and trophic transfer -- 7: Diversity patterns across aquatic communities from peat bogs -- 8: Hydrologic Systems, water uses and emerging conflicts around freshwater availability in Patagonia -- 9: Land-use effects on aquatic ecosystems: An overview of environmental impacts and tools for ecological assessment -- 10: Patagonian wetlands: vertientes, vegas, mallines,turberas and lagunas -- 11: Fish and fisheries of the Patagonian steppe -- 12: Invasive species: The case of Didymosphenia geminata in Neuquén Province -- 13: Influence of the fish introduction in lakes of the arid Patagonia -- 14: Patagonian cultural limnology: knowledge and water management in Mapuche rural communities -- 15: Political Ecology, water valoration and Water Law deliberation in the Province of Tierra del Nacional de Tierra del Fuego -- 16: Freshwater systems in protected areas in Patagonia -- 17: Amphibians and waterbirds as bridges to conserve aquatic and terrestrial habitat in Patagonia -- 18: Integrated long term conservation strategies to recover the critically endangered Hooded Grebe (Podiceps gallardoi),an endemic waterbird of Austral Patagonia -- Conclusion: Reaching out for the UNDP Sustainable Development Goals in Patagonia.
    Abstract: The Freshwaters of Patagonia adopts a socioecological approach, in which experts from across Patagonia review recent, scientifically rigorous literature and data of their own, thus synthesizing the current knowledge directly relevant to understand the present state and future trends of icefields, freshwater and wetland ecosystems in this region. The book’s organization into three parts provides a studied and comprehensive view on the patterns and processes of the various ecosystems in Patagonia, and describes the sociological aspects of freshwater ecosystems, as well as characterizes the conservation of the freshwater and wetland ecosystems, in Patagonia. The chapters offer a broad, state-of-the-art overview of the current status of glaciers, freshwater and wetland ecosystems of this region, as well as studies of both local and large scale biodiversity patterns, and study cases of extreme and naturally polluted environments.The volume concludes with the current status of Patagonian freshwaters, and discusses the scientific, legal and administrative tools aimed at their sustainable management within the framework of the UNEP Sustainable Development Goals 2030 Agenda. A broad audience of students, scientists, engineers, environmental managers, and policy makers will be interested in this volume.
    Type of Medium: Online Resource
    Pages: XI, 541 p. 104 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031100277
    Series Statement: Natural and Social Sciences of Patagonia,
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Oncology. ; Immunology. ; Metastasis. ; Cytology. ; Cancer Biology. ; Oncology. ; Immunology. ; Metastasis. ; Cell Biology.
    Description / Table of Contents: Chapter 1. A Systemic View of Metastatic Disease: Inter-organ Crosstalk and Therapeutic Implications -- Part I. Systemic Regulation in Metastatic Disease -- Chapter 2. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles -- Chapter 3. Bone Metastasis: Systemic Regulation and Impact on Host -- Chapter 4. Targeting Metastatic Disease: Challenges and New Opportunities -- Part II. Cachexia: A Debilitating Systemic Effect of Cancer -- Chapter 5. Signaling Pathways That Promote Muscle Catabolism in Cachexia -- Chapter 6. The Role of Interleukin-6 Cytokines in Cancer Cachexia -- Chapter 7. NF-kB Signaling in the Macroenvironment of Cancer Cachexia -- Part III. Therapy-induced Muscle Wasting -- Chapter 8. Therapy-induced Toxicities Associated with the Onset of Cachexia -- Chapter 9. Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy -- Part IV. Preventing and Targeting Cachexia in Cancer -- Chapter 10. New Developments in Targeting Cancer Cachexia -- Chapter 11. Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer.
    Abstract: This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.
    Type of Medium: Online Resource
    Pages: VI, 203 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031095184
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Zoology. ; Biodiversity. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Ecology. ; Zoology. ; Biodiversity.
    Description / Table of Contents: Introduction: Christopher Clark and Ellen Garland -- Ch 1: Overview. Christopher Clark -- Ch. 2: Anatomy and physiology. Joy Reidenberg -- Ch. 3: Movement, Residency & Migration. Alex Zerbini and Sue Moore,- Ch. 4: Feeding strategies. Ari Friedlaender -- Ch. 5: Molecular genetics. Emma Carroll -- Ch. 6: Social organization. Peter Tyack -- Ch. 7: Ethological and bioacoustic variability. Christopher Clark -- Ch. 8: Baleen whale culture. Ellen Garland and Emma Carroll -- Ch. 9: Blue whale – Global diversity & behavioral variability in a specialist. Ana Sirovic -- Ch. 10: Humpback whale – Global diversity & behavioral plasticity in a court jester. Rebecca Dunlop -- Ch. 11: Humpback whale song - Global diversity & behavioral plasticity in a court jester. Danielle Cholewiak, Sal Cerchio and Ellen Garland -- Ch. 12: Bowhead whale – Acoustic variability in the almost-a-right whale that went north. Kate Stafford -- Ch. 13: Right whales - From north to south, what’s the big difference? Susan Parks -- Ch. 14: Minke Whale – Diversity and variability. Denise Risch -- Ch. 15: Omura’s Whale – An enigma. Sal Cerchio. .
    Abstract: In this book, an international team of leading marine mammal scientists, with a remarkably diverse set of backgrounds and areas of expertise, lead you through a synthesis of current knowledge on baleen whales. Baleen whales are the largest animals ever to have lived on this planet. They also have the lowest and most intense voices on Earth, most likely evolved to take advantage of ocean acoustic transmission conditions so as to be detectable across ocean basins. Some baleen whales can live to be 150-200 years old. They migrate many thousands of kilometers between feeding and breeding areas. They produce songs and calls that serve as behavioral foundations for establishing, maintaining and expanding their cultural identities. To conclude that we know the behavioral limits of these large brained, long-lived animals would be naïve. As baleen whale scientists, we are still beginning to comprehend the enormous complexities and natural histories of these remarkable animals. Today, the fact that whales sing is known throughout much of the world. This awareness started 50 years ago with the publication and popularization of a collection of humpback song recordings that motivated research into baleen whale behavioral ethology. In this book’s chapters, a reader’s experiences will stretch from learning about baleen whale laryngeal anatomy associated with their different voices to learning about the vast ocean areas over which their voices can be heard and the emerging complexities of their culturally defined societies. These are accompanied by chapters on the fundamental ethological contexts of socializing, migrating, and foraging. Two common themes permeate the book. One theme highlights the phenomenal increase in scientific knowledge achieved through technological advancements. The other theme recognizes the impacts of human-made activities on ocean acoustic environments and the resultant influences on the health and survival of individual whales and their populations. Although the book is intentionally ambitious in its scope, as scientists, we fully recognize that baleen whale science is still in its infancy. Many profound revelations await discovery by cohorts of young, multi-talented explorers, some of whom are stretching their wings in this volume and some of whom are reading these scientific stories for the first time.
    Type of Medium: Online Resource
    Pages: XVI, 384 p. 87 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030984496
    Series Statement: Ethology and Behavioral Ecology of Marine Mammals,
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Biotic communities. ; Biodiversity. ; Population biology. ; Microbial ecology. ; Freshwater and Marine Ecology. ; Ecosystems. ; Biodiversity. ; Community and Population Ecology. ; Microbial Ecology.
    Description / Table of Contents: Chapter 1 Lake Alchichica: History of Human Settlements -- Chapter 2 Geological Evolution of the Alchichica Crater -- Chapter 3 Paleoenvironmental Change in Central Mexico During the Last 20,000 Years -- Chapter 4 Recent Climate of Serdán-Oriental Basin -- Chapter 5 Hydrogeology and Hydrochemistry of the Serdán-Oriental Basin and the Lake Alchichica -- Chapter 6 Meteorological Regime, Local Climate, and Hydrodynamics of Lake Alchichica -- Chapter 7 Physicochemical Characteristics -- Chapter 8 The Littoral Environment -- Chapter 9 Aquatic Vegetation -- Chapter 10 The Littoral Community -- Chapter 11 Bacterioplankton -- Chapter 12 -- Phytoplankton of Alchichica: A Unique Community for an Oligotrophic Lake -- Chapter 13 Protozooplankton -- Chapter 14 Metazooplankton: The Joys and Challenges of Living in a Saline, Oligotrophic, Warm Monomictic Lake -- Chapter 15 Alchichica Silverside -- Chapter 16 -- The Axolotl of Alchichica -- Chapter 17 The Deep Benthic Zone. - Chapter 18 Lake Metabolism. - Chapter 19 Lake Food Webs -- Chapter 20 Diversity and Endemisms -- Chapter 21 Conservation Actions -- Chapter 22 Microbialites: Diversity Hotspots in the Mexican Plateau -- Chapter 23 The Lake Alchichica from an Astrobiological Perspective -- Chapter 24 Lake Alchichica Traditions, Myths, and Legends: Interviews with Local Residents. .
    Abstract: The book provides a comprehensive account of a tropical lake, Alchichica, considering that tropical limnology is by far less well-understood than temperate. Many of the well-known temperate limnology paradigms do not apply in tropical limnology, such as the ≥ 1ºC/m thermocline concept, or the role of phosphorous as limiting nutrient. Lake Alchichica is - most likely – the best limnologically known Mexican lake up to date. Twenty years of continuous monitoring has led us to understand this deep, warm monomictic lake. The peculiar chemical composition of this saline lake – sodium-alkaline with high concentration in magnesium waters, and groundwater-fed – led to the formation of its unique stromatolite ring that has become world-famous, studied by scientists from various countries. From a biological point of view, this relatively small maar lake displays a low species richness, but surprisingly is plentiful in microendemic species for a recently-formed lake (12,000 years old, at the onset of Holocene Epoch), eleven of which already described, with more to come. Researchers and students interested in tropical limnology, extreme ecosystems, evolutionary biology, and microbiology will find this book a must-read.
    Type of Medium: Online Resource
    Pages: XXI, 433 p. 179 illus., 144 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030790967
    DDC: 577.6
    Language: English
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    Keywords: Cancer. ; Tumors Immunological aspects. ; Cancer Treatment. ; Biochemistry. ; Metabolism. ; Cell biology. ; Immunology. ; Cancer Biology. ; Cancer Microenvironment. ; Tumour Immunology. ; Cancer Therapy. ; Metabolic Pathways. ; Immunology.
    Description / Table of Contents: 1 Cancer Metabolism and Aggressive Tumor Behaviour -- 2 Immune Cell Metabolism and Function -- 3 Cancer Cell Metabolism Effecting Immune function -- 4 Immune Cell Metabolites as Fuel for Cancer Cells -- 5 Immuno-Onco metabolism and Resistance to Therapy -- 6 Targeting Immuno-Onco metaolism in Cancers -- 7 Timing of the major metabolic switches in immune cell activation and differentiation during cancer development.
    Abstract: This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.
    Type of Medium: Online Resource
    Pages: X, 218 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811662263
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Biodiversity. ; Zoology. ; Behavior genetics. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Ecology. ; Biodiversity. ; Zoology. ; Behavioral Genetics.
    Description / Table of Contents: Evolution – Analisa Berta -- Sensory and cognition – Tentative Colleen Reichmuth and others -- Communication – Isabelle Charrier -- Physiology – Dan Crocker -- Movement – Luis Huckstadt and Ryan Reisinger -- Navigation – Patrick Robinson -- Foraging ecology and behavior – Don Bowen -- Reproductive behavior and lactation strategies – Dan Costa and Jen Maresh -- Breeding behavior – Paddy Pomeroy and Kelly Robinson -- Conservation – Samantha Simmons and others.
    Abstract: Phocid (or earless or true) seals are ecologically diverse, occupying habitats from the tropics to the poles in marine and freshwater and feeding on anything from tiny zooplankton to other marine mammals. There are 18 species of phocid seals, the smallest species (ringed seal) is more than 20 times smaller than the largest (southern elephant seal), with marked sexual dimorphism present in some species. This book examines the behavior, ecology, and physiology that allow phocid seals to inhabit such a wide range of habitats. The book is composed of 16 chapters written by 37 authors from 8 countries. The book first describes the general patterns of phocid behavior, followed by descriptions of what is known about well-studied species. We have taken a holistic approach, focusing not only on the behaviors themselves but also on the factors that constrain the expression of behavior and the proximate mechanisms driving behavior. In many cases, the chapters represent collaborations between well-established researchers and early-mid career individuals who bring new perspectives to help carry the field of phocid behavioral ecology well into the future.
    Type of Medium: Online Resource
    Pages: XVIII, 645 p. 180 illus., 161 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030889234
    Series Statement: Ethology and Behavioral Ecology of Marine Mammals,
    DDC: 577.6
    Language: English
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    Keywords: Cancer. ; Metastasis. ; Lymphatics. ; Cancer Biology. ; Metastasis. ; Lymphatic System.
    Description / Table of Contents: Section 1: Genetic and Molecular Pathways of Cancer Growth and Metastasis -- Chapter 1. Hallmarks of Cancer: Molecular Underpinnings -- Chapter 2. Unifying concept of genomic changes: The mutational landscape of cancers -- Chapter 3. Tumor Microenvironment: Coconspirator in Tumorigenesis -- Chapter 4. Hallmarks of Metastasis: Molecular Underpinnings -- Chapter 5. Hereditary Cancer Syndromes and Cancer Metastasis -- Section 2: Pathology of Cancer Growth and Metastasis -- Chapter 6. Pathologic Assessment of Lymph Node Metastasis -- Chapter 7. Pathologic Assessment of Systemic or Distant Metastasis -- Chapter 8. The Role of Angiotropic Extravascular Migratory Metastasis in Metastases -- Section 3: Dormant Cancer Cells and their Reactivation in the Host Cancer Microenvironment -- Chapter 9. Tumor Dormancy and Relapse Regulated by the Extracellular Matrix -- Chapter 10. Therapy-Induced Dormancy and Residual Disease -- Section 4: The Microenvironment of Site-Specific Metastasis - Isaac P. Witz -- Chapter 11. The Microenvironment of Site-Specific Metastasis -- Section 5: Circulating Cancer Cells and Liquid Biopsy -- Chapter 12. Circulating tumor cells and ctDNA in sarcomas -- Chapter 13. Liquid biopsy using cell-free tumor DNA for gastrointestinal cancers -- Chapter 14. Circulating tumor cells and ctDNA in prostate cancer.-Chapter 15. Circulating Tumor Cells in Lung Cancer -- Chapter 16. CTCs/ ctDNA and Brain Metastasis.-Chapter 17. Epigenetics and liquid biopsy in oncology: role in metastasis and clinical utility -- Chapter 18. Metabolic reprogramming of circulating tumor cells for metastasis -- Section 6: Lymphatic System and Cancer Metastasis -- Chapter 19. Lymphatic System Biology, Pathobiology, and Relation to Cancer Metastasis -- Chapter 20. Lymphatic Specification and Development, EMT-MET, and Cancer Spread -- Chapter 21. Lymphangiogenesis, Lymph Nodes, Cancer Lymphangiogenesis and Metastasis -- Chapter 22. Immune cell trafficking in the lymphatics, hyaluronan biology and tumour metastasis -- Chapter 23. Lymphvascular Genomics and Proteomics, Clinical Syndromes, and Cancer Metastasis -- Chapter 24. Imaging of the Lymphatic System with Relevance to Cancer and Cancer Metastasis -- Chapter 25. Lymphedema: general pathophysiology, prevention and management in invasive cancer -- Section 7: Radiological Imaging of Early Cancer and Cancer Metastases -- Chapter 26. Primary Tumor Staging and Detection of Common Sites of Distant Metastatic Disease -- Chapter 27. Imaging Modalities in the Detection and Diagnosis of Metastatic Disease -- Chapter 28. Imaging of Bone Metastases -- Chapter 29. Imaging of Lung and Soft Tissue Metastases -- Chapter 30. Image-Guided Biopsy and Intervention for Metastatic Disease -- Section 8: Sentinel Lymph Node Surgery for Solid Cancer. Chapter 31. Sentinel Lymph Node Biopsy for Primary Cutaneous Malignancy -- Chapter 32. Sentinel Lymph Node Biopsy in Breast Cancer -- Chapter 33. Sentinel node navigation surgery for upper gastrointestinal cancer -- Chapter 34. Sentinel Lymph Node Mapping in Non-Small Cell Lung, Colon, and Thyroid Carcinomas -- Section 9: Surgical Treatment of Primary and Metastatic Cancer -- Chapter 35. The efficacy and evolution of surgical management based on cancer biology -- Chapter 36. The role of surgery in managing primary and metastatic melanoma -- Chapter 37. The Role of Surgery in Managing Primary and Metastatic Breast Cancer -- Chapter 38. The role of surgery in managing primary and metastatic colorectal cancer -- Chapter 39. The Role of Surgery in Management of Gastric Cancer -- Chapter 40. The role of surgery in managing primary and metastatic hepatopancreaticobiliary cancers -- Section 10: Cancer Metastasis to the Lung -- Chapter 41. Metastatic disease of the lung -- Section 11: Cancer Metastasis to the Liver -- Chapter 42. Tumor Resection and Ablation as a Means of Controlling Hepatic Metastases -- Chapter 43. Regional Arterial Infusional Therapy as a Means of Controlling Hepatic Metastases -- Section 12: Cancer Metastasis to the Bone -- Chapter 44. Molecular Mechanisms of Metastasis to the Bone.-Chapter 45. Surgical Management of Metastatic Disease to the Upper Extremity -- Chapter 46. Surgical Management of Metastatic Disease to the Lower Extremity -- Chapter 47. Surgical management of metastatic disease to the pelvis -- Chapter 48. Surgical Management of Metastatic Disease to the Spine -- Chapter 49. Interventional radiology techniques for management of skeletal metastases -- Section 13: Cancer Metastasis to the Brain and the Nervous System -- Chapter 50. Brain Metastases: Overview and Molecular Mechanisms -- Chapter 51. Indications and Techniques for Surgical Intervention in Patients with Metastatic Brain Tumors -- Chapter 52. Brain Metastases: Current and Future pharmacological treatment -- Chapter 53. Radiotherapy for CNS Metastases -- Chapter 54. Leptomeningeal Carcinomatoses -- Section 14: Urologic Cancer and 1st Patterns of Metastasis -- Chapter 55. Urologic Cancer and 1st Patterns of Metastasis -- Section 15: Biology and Clinical Aspects of Sarcoma Progression -- Chapter 56. Soft Tissue Sarcoma -- Chapter 57. Bone Sarcoma -- Chapter 58. Liposarcoma Metastasis -- Chapter 59. Desmoid Tumors.-Chapter 60. Atypical patterns of metastases: How do Sarcoma’s metastasize? -- Chapter 61. Tumor Immune Microenvironment of Soft Tissue Sarcoma -- Section 16: The Role of Radiation in the Treatment of Primary and Metastatic Cancer -- Chapter 62. Basic Principles of Radiobiology and Cancer Metastasis Prevention -- Chapter 63. Technical Innovations in the Delivery of Radiation Therapy -- Chapter 64. Radiation Therapy in the Definitive Treatment of Cancer -- Chapter 65. Radiation Therapy for Extracranial Oligometastatic Disease -- Chapter 66. Spine Radiotherapy -- Section 17: Immunotherapy of Solid Malignancies -- Chapter 67. Immunotherapy in Melanoma and Merkel Cell Cancer -- Chapter 68. Landscape of Immunotherapy in Lung Cancer -- Chapter 69. Immuno-oncologic Treatment of Genitourinary Malignancies -- Section 18: Current Topics -- Chapter 70. Personalized Systemic Cancer Therapy -- Chapter 71. Cancer Stem Cells and Their Role in Metastasis -- Chapter 72. HPV Induced Cancers -- Chapter 73. Microbiome and Cancer Metastasis -- Chapter 74. Application of Artificial Intelligence in Research on Cancer and Its Metastasis.
    Abstract: This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. .
    Type of Medium: Online Resource
    Pages: XXIV, 806 p. 145 illus., 106 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030930844
    DDC: 571.978
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Tumor markers. ; Non-coding RNA. ; Cancers. ; Tumour Biomarkers. ; Non-coding RNAs.
    Description / Table of Contents: Chapter 1. The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective -- Chapter 2. Circulating MicroRNAs as Cancer Biomarkers in Liquid Biopsies -- Chapter 3. Regulation of Immune Cells by MicroRNAs and MicroRNA-Based Cancer Immunotherapy -- Chapter 4. Machine-Learning-Based Methods and Best Practices of MicroRNA-Target Prediction and Validation -- Chapter 5. Turning Data to Knowledge: Online Tools, Databases and Resources in MicroRNA Research -- Chapter 6. Bioinformatics Methods for Modeling MicroRNA Regulatory Networks in Cancer -- Chapter 7. Analysis of the p53/MicroRNA Network in Cancer -- Chapter 8. Machine Learning Using Gene-Sets to Infer miRNA Function -- Chapter 9. miRNA:miRNA Interactions: A Novel Mode of miRNA Regulation and Its Effect on Disease -- Chapter 10. ClustMMRA v2: A Scalable Computational Pipeline for the Identification of MicroRNA Clusters Acting Cooperatively on Tumor Molecular Subgroups -- Chapter 11. 3D Modeling of Non-coding RNA Interactions.
    Abstract: This book provides an update on the latest development in the field of microRNAs in cancer research with an emphasis on translational research. Since the early 2000s, microRNAs have been recognized as important and ubiquitous regulators of gene expression. Soon it became evident that their deregulation can cause human diseases including cancer. This book focuses on the emerging opportunities for the application of microRNA research in clinical practice. In this context, computer models are presented that can help to identify novel biomarkers, e.g. in circulating microRNAs, and tools that can help to design microRNA-based therapeutic interventions. Other chapters evaluate the role of microRNAs in immunotherapy, immune responses and drug resistance. Covering key topics on microRNAs in cancer research this book is a valuable resource for both emerging and established microRNA researchers who want to explore the potential of microRNAs as therapeutic targets or co-adjuvants in cancer therapies.
    Type of Medium: Online Resource
    Pages: VII, 317 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031083563
    Series Statement: Advances in Experimental Medicine and Biology, 1385
    DDC: 571.978
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Microbial ecology. ; Vertebrates. ; Physiology. ; Nutrition   . ; Metabolism. ; Freshwater and Marine Ecology. ; Microbial Ecology. ; Vertebrate Zoology. ; Animal Physiology. ; Nutrition. ; Metabolism.
    Description / Table of Contents: Introduction -- Source and Screening of Probiotic Microorganisms -- Application Methods of Probiotics and Options -- Use of Probiotics in Finfish -- Use of Probiotics in Shellfish -- Paraprobiotics in Aquaculture -- Probiotics for Controlling Infectious Diseases -- Probiotics for Biofloc System and Water Quality -- Probiotics as Vaccine Adjuvants -- Modes of Action of Probiotics -- Factors Influencing the Efficacy of Probiotics -- Quality, Safety and Regulatory Issues of Probiotics -- Methods Used for Selecting and Evaluating Probiotics -- Conclusions.
    Abstract: This book has been developed to provide a detailed discussion of probiotics, which have been evaluated for use predominantly in fish and shellfish aquaculture. This book highlights strengths and weaknesses in knowledge and discusses gaps that need to be addressed. There has been a great deal of research concerning the use of probiotics in aquaculture. To date, a wide range of Gram-positive and Gram-negative bacteria and some eukaryotes, i.e. yeasts and unicellular algae, has been reported to be beneficial to aquatic hosts. Following oral uptake, benefit includes improved growth performance and protection against many bacteria and some parasitic diseases. This book will be suitable for scientists, veterinarians, professionals, and senior students involved in aquaculture. .
    Type of Medium: Online Resource
    Pages: XVIII, 308 p. 29 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030986216
    DDC: 577.6
    Language: English
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    Keywords: Cancer. ; Cytology. ; Clinical biochemistry. ; Cancer Biology. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.
    Abstract: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: X, 494 p. 40 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030997083
    Series Statement: Biology of Extracellular Matrix, 11
    DDC: 571.978
    Language: English
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    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Cancer Epidemiology. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Epidemiology. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Module 1_Overview of Breast Cancer -- Module 2_Cell and Molecular Biology of Breast Cancer-Diagnosis and Prognosis -- Module 3_Breast Cancer Treatment.
    Abstract: This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy. Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.
    Type of Medium: Online Resource
    Pages: XVII, 536 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811901973
    DDC: 571.978
    Language: English
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    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Biodiversity. ; Zoology. ; Behavior genetics. ; Vertebrates. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Biodiversity. ; Zoology. ; Behavioral Genetics. ; Vertebrate Zoology.
    Description / Table of Contents: Neuroethological background of marine mammal complexity -- Social extremes and their relation to anthropogenic stress -- Lone, sociable marine mammals and their influence on human attitudes -- Efforts of conserving marine mammals (spaces excluded) -- Conserving marine mammal spaces and habitats -- Conservation relevance of marine mammal social learning and culture -- Marine mammal migrations.
    Abstract: The seventh volume in the series “Ethology and Behavioral Ecology of Marine Mammals” describes aspects of the often-complex relationship between humans and marine mammals. From a primeval condition of occasional predators, during the last century humans have become a major factor negatively affecting the status of most marine mammals through over-hunting, habitat encroachment and environmental degradation. This has led to the extirpation of many marine mammal populations and even to the extinction of species. However, in parallel to this destructive drive, since antiquity humanity has been influenced by a strong fascination for marine mammals, which contributes today to an increased human appreciation of the natural world admixed with widespread concern for its degrading condition. The special status occupied by marine mammals in human imagination and affection stands in stark contrast with the current predicament of many populations still threatened by the doings of Homo sapiens: a condition emblematic of the relationship of humanity with nature, and key to understanding where humanity is heading.
    Type of Medium: Online Resource
    Pages: XXII, 465 p. 88 illus., 80 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030981006
    Series Statement: Ethology and Behavioral Ecology of Marine Mammals,
    DDC: 577.6
    Language: English
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    Keywords: Freshwater ecology. ; Marine ecology. ; Environmental management. ; Water. ; Hydrology. ; Pollution. ; Refuse and refuse disposal. ; Forestry. ; Freshwater and Marine Ecology. ; Environmental Management. ; Water. ; Pollution. ; Waste Management/Waste Technology. ; Forestry.
    Description / Table of Contents: Chapter 1. Phenology of photosynthesis in a deciduous broadleaf forest: implications for the carbon cycle in a changing environment -- Chapter 2. Ecological significance of throughfall and stemflow to the carbon cycle in forest ecosystems -- Chapter 3.Forest carbon sequestration in mountainous region in Japan under ongoing climate change: implication for future research -- Chapter 4. Woody biomass change monitoring in temperate montane forests by airborne LiDAR analysis -- Chapter 5. Semi-natural grasslands maintained by controlled burning in Japan - Air and soil temperature and plant diversity -- Chapter 6. Detection and Identification of Phytophthora Pathogens That are Threatening Forest Ecosystems Worldwide -- Chapter 7. Water quality safety and security - from evaluation to control -- Chapter 8. Energy Recovery from Wastewater -- Chapter 9. Management of on-site household wastewater treatment systems (Johkasou) in Japan -- Chapter 10. Predicting fine sediment deposition rate in low-land river channel: Comparison of two adjacent rivers -- Chapter 11. Relationship between forest stand condition and water balance in a forested basin -- Chapter 12. Plant pathogenic oomycetes inhabiting river water are a potential source of infestation in agricultural areas -- Chapter 13. Soil contamination and conservation -- Chapter 14. Evaporation in arid regions -- Chapter 15. Feature Extraction and Analysis of Earthquake Motion -- Chapter 16. Involving the community to manage natural disasters: A study of Japanese disaster risk reduction practices.
    Abstract: This book provides updated and comprehensive information on the evaluation of the river basin environment, along with its management and conservation. The chapters collected the latest cutting-edge research achievements in vegetation function evaluation, remote sensing monitoring and analysis, water quality evaluation and control, water and wastewater treatment, soil remediation, forest resource management, microbial disease diagnosis and more, the key components that link directly with the safety, security and sustainability of river basin environment. This book emphasizes the important aspects for better and more effective evaluation, management and conservation of the river basin environment, the foundation for its sustainable utilization and development, the foundation for achieving water and food security, and the United Nations’ SDGs for No Poverty (1), Zero Hunger (2) and Clean Water and Sanitation (6), as well as Affordable and Clean Energy (7), Sustainable Cities and Communities (11), Climate Action (13), Life below Water (14) and Life on Land (15). This book will benefit the research community and environmental education. It will prove useful to students, water and forest resource managers, hydrologists and all those engaged or interested in any aspect of evaluation, management, and conservation of the river basin environment. The book also has the potential to inform multi-regional and sectoral policies in all regions of the world and contribute to sustainable development solutions through better management of water, soil, and vegetation resources.
    Type of Medium: Online Resource
    Pages: X, 356 p. 152 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811940705
    DDC: 577.6
    Language: English
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    Keywords: Freshwater ecology. ; Marine ecology. ; Biotic communities. ; Population biology. ; Ecology . ; Freshwater and Marine Ecology. ; Community and Population Ecology. ; Ecology.
    Description / Table of Contents: 1. The Perspective of climate change on aquatic environment and fish production -- 2. Climate Change: Stressor on Marine Buffer System -- 3. Climate Change: Impact on Fauna and Fishing Activity 0f River -- 4. Possible Impact of Climate Change on Fisheries -- 5. Impact of global warming on changing pattern of biodiversity and fish production in inland open waters -- 6. Climate Change and Coral Reef Ecosystem: Impacts and Management Strategies -- 7. Implications of Climate Change on Fisheries and Food Security -- 8. Nexus of climate change with fish production and its implications on livelihood and nutritional security -- 9. Gut microbes and its physiological role in fish: adaptive strategies for climatic variability -- 10. Metabolic adaptation of fishes under different consequences of climate change -- 11. Argulus Parasitism in Aquaculture: An Elevated Temperature Scenario -- 12. Effect of environmental variability on the pigmentation of Fishes -- 13. Climate Change and stress Response in Teleost. 14. Impact of Climate Change on Emergence of Biotoxin in Fish and Shellfish -- 15. Metabolomic response to high temperature stress in murrel Channa striatus and insights for designer feeds -- 16. Feed and feeding management for sustainable growth and health of fish in varying climatic condition -- 17. Vulnerability and Mitigation Approach to Nutritional Pathology for Sustainable Fish Growth in Changing Climatic Conditions -- 18. Technology Prioritization For Climate-Resilient Nutritive Fish -- 19. Role of Dietary supplements in stress amelioration of teleost fishes -- 20. Dealing the hardship in aquaculture nutrition in a changing climatic condition -- 21. Strategies to mitigate climate change-imposed challenges in fish nutrition -- 22. Duckweed-based circular aquaculture for climate resilience and carbon foot-print reduction of fed Aquaculture -- 23. Nutraceuticals in aquaculture: a prospective climate change adaptation strategy -- 24. Broodstock development, induced breeding, and seed production of climbing perch Anabas testudineus: An alternative aquaculture species for changing environment -- 25. Effect of changing environmental factors on reproductive cycle and endocrinology of fishes -- 26. Impact of climate change on fish reproduction and climate-resilient broodstock management -- 27. Nutrition and environment interactions in aquaculture -- 28. Reproductive and maternal nutrition in changing climatic conditions.
    Abstract: The edited book covers the climate change impact broadly across the ecosystems including increasing pressure on livelihood and food supplies to the society. Climate change, in particular, rising temperatures, can have both direct and indirect effects on global fish production. Fisheries and aquaculture is one of the important sectors of agriculture for livelihood and nutritional security. Fish, being poikilothermic in nature are very sensitive to any change in the ecosystem. In commercial aquaculture, it is crucial to ensure that environmental rearing conditions are adequate, if not optimal, for fish growth, welfare and profitability. Thus, the book develops an understanding regarding changes in relevant environmental parameters and its affect in the growth and physiological performance of fish. Fish feeds on natural food organisms, but the adverse changes in the ecosystem attracts nutritionists to provide better food and feeding strategies for optimum growth and survival of the fish. it is become necessary to develop preparedness about the changes and their mitigation strategies through fish nutrition and feeding strategies. This book address the potential impact of climate change on the aquaculture sector under sections - Assessment of Global Warming Impact on aquatic resources and fish production, Adaptation in Fish Digestive Physiology and Biochemistry under Changing Environment, Prioritization of fish feed technology with respect to changing climate for adaptation and mitigation, Strategies and planning on reproductive physiology and feed management for biodiversity conservation. The chapters are contributed by the experts in the field of fish nutrition and physiology. The book assists fish farmers, entrepreneurs, planners and advisors specifically related to nutritional and physico-biochemical changes in fishes to adapt or mitigate the adverse effect of climate change.
    Type of Medium: Online Resource
    Pages: XVIII, 433 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811955006
    DDC: 577.6
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Ecology . ; Oceanography. ; Biotic communities. ; Population biology. ; Freshwater and Marine Ecology. ; Biooceanography. ; Community and Population Ecology.
    Description / Table of Contents: 1 – Presentation and introduction -- 2 – Dedication (to Genevieve Corwin) -- 3 – Comprehensive Italian annotated bibliography on bluefin tuna, Thunnus thynnus (Linnaeus, 1758) -- 4 – Comprehensive Italian annotated bibliography on albacore tuna, Thunnus alalunga (Bonnaterre, 1788) -- 5 – Comprehensive Italian annotated bibliography on small tunas (or: on small tunas species, tbd) -- 6 – Comprehensive Italian annotated blibliography on tropical tunas species -- 7 – Comprehensive Italian annotated bibliography on swordfish, Xiphias gladius, Linnaeus, 1758 -- 8 – Comprehensive Italian annotated bibliography on Mediterranean spearfish, Tetrapturus belone, Rafinesque, 1810, and other Istiophoridae.
    Abstract: The Italian-annotated bibliography on tunas, tuna-like and billfish species is a sort of unicum, because for the very first time, it provides annotation in English for all papers published by Italian authors over the centuries in various languages. Taking into account that these species are an essential component of the Italian and Mediterranean culture, thousands of authors published a very high amount of papers since historical times, on various themes and subjects. These large fish species are nowadays not only essential elements of the marine trophic chain, but also important components of human seafood and the related fishery economy. This book makes all these papers internationally available for all scientists, helping them in their research activities and the annotations facilitate the searching work by species and keywords.
    Type of Medium: Online Resource
    Pages: XXI, 908 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030910693
    DDC: 577.6
    Language: English
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    Singapore :Springer Nature Singapore :
    Keywords: Freshwater ecology. ; Marine ecology. ; Immunology. ; Animal culture. ; Freshwater and Marine Ecology. ; Immunology. ; Animal Science.
    Description / Table of Contents: Chapter 1. Overview of fish immune system -- Chapter 2. Shrimp immune system and immune responses -- Chapter 3. Types of vaccines used in aquaculture -- Chapter 4. Vaccines against bacterial pathogens of fish -- Chapter 5. Viral vaccines for farmed finfish -- Chapter 6. Vaccines for parasitic diseases of fish -- Chapter 7. Bacterial biofilm for oral vaccination in aquaculture -- Chapter 8. RNA interference vaccines for disease control in aquaculture -- Chapter 9. Prospects of vaccination in crustaceans with special reference to shrimp -- Chapter 10. Methods of vaccine delivery -- Chapter 11. Adjuvants for fish vaccines -- Chapter 12. Role of pattern recognition receptors and interferons in fish vaccination -- Chapter 13. Evaluating efficacy of vaccines in finfish -- Chapter 14. Biosafety and regulatory requirements for vaccines -- Chapter 15. Adverse effects of fish vaccines.
    Abstract: This book is a collection of comprehensive and latest information on all aspects of vaccination in fish and shellfish. It provides the basic understanding about the immune system of both fish and crustaceans, besides giving the latest information on adjuvants, vaccine delivery methods, adverse effects of vaccines and methods to assess the efficacy of vaccines. Separate chapters on the role of pattern recognition receptors and interferons in fish vaccination, biofilm vaccines and biosafety and regulatory requirements for fish vaccines are also included. Aquaculture, being the fastest growing food producing industry in the world, is looked upon for alleviating the malnutrition especially among the under privileged population. However, intensive aquaculture practices have led to increased incidences of diseases and significant production losses. Among various health management measures employed in aquaculture, vaccination has been proven to be the best approach to protect fish against pathogens. It is considered to be safe and is a key factor for sustainable aquaculture. In this background, apart from the basic understanding of fish and shellfish immune system, updated knowledge on various types of vaccines and the vaccination strategies currently employed in aquaculture are also covered. The book is designed to provide the latest and comprehensive knowledge on all these aspects as a compiled resource material which is useful to students, researchers and other professionals in the field of aquaculture.
    Type of Medium: Online Resource
    Pages: IX, 290 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811912689
    DDC: 577.6
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Invertebrates. ; Freshwater and Marine Ecology. ; Biodiversity. ; Invertebrate Zoology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Morphology of Free-living Nematode -- Chapter 3. Materials and Methods -- Chapter 4. Systematics and taxanomy -- Chapter 5. Order Araeolaimida De Coninck & Schuurmans Stekhoven, 1933 -- Chapter 6. Order Chromadorida Chitwood, 1933 -- Chapter 7. Order Desmodorida De Coninck, 1965 -- Chapter 8. Order Desmoscolecida Filipjev, 1929 -- Chapter 9. Order Monhysterida Filipjev, 1929 -- Chapter 10. Order Plectida Gadea, 1973 -- Chapter 11. Order Enoplida Filipjev, 1929 -- Index to families, genera and species.
    Abstract: This book describes and illustrates 300 species of free-living marine nematodes from the East China Sea and includes eighteen new species. Free-living marine nematode is the most dominant and diverse meiofaunal group in marine benthic habitats. It has strong adaptability and wide distribution, and plays a very important role in the material circulation and energy flow of benthic ecosystem. Up to now, about 7,000 species of free-living marine forms (attached to 2 Class, 8 Order, 86 Family, 662 genera) have been recorded around the world. Some 500 species have so far been reported from the sea areas of China. Among them, more than 300 species were identified from the East China Sea. The book will provide basic data and information of free-living marine nematodes for ecosystem management, protection and utilization of marine biological resources in the East China Sea.
    Type of Medium: Online Resource
    Pages: XIV, 409 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811638367
    DDC: 577.6
    Language: English
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    Keywords: Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Bioclimatology. ; Freshwater and Marine Ecology. ; Biodiversity. ; Climate Change Ecology.
    Description / Table of Contents: Chapter 1. Introduction and Background -- Chapter 2. Anthropogenic Environmental Impacts on Coral Reefs in the Western and South-Western Pacific Ocean -- Chapter 3. Advances in Coral Biology -- Chapter 4. Reef Ecology in the Western Pacific for Adaptation to Global Change -- Chapter 5. Biogeochemical Dynamics of Coral Reef Systems -- Chapter 6. Environmental and Climate Proxies Embedded in Coral Skeletons -- Chapter 7. Synthesis and Future Perspectives on the Coral Reefs in the Western Pacific Region.
    Abstract: The monograph is based on the research and training activities in the Western Pacific Ocean Region within the umbrella of UNESCO/IOC-Sub-Commission for the Western Pacific Region. The results of these activities are compared to cases from other tropical and subtropical regions on this planet to make the knowledge applicable to global aspects of sustainability of coral reef ecosystems. In this monograph, we examine the coral reefs from viewpoint of multidisciplinary approaches, including, environmental impacts, coral biology and system ecology, biogeochemical cycles and processes that drive the material and energy flow through the food web, as well as the proxies in geochemistry that have been used to track the responses of coral reefs to the changing climate and human perturbations. Although this study is focused on the Western Pacific Ocean, the Western Pacific Ocean is so large and diverse that most reef environment types on this planet are located within it. Therefore, knowledge gained in this study is relevant to the application of coastal management in practice as well as in the teaching classes on the interactions between coral reef ecosystems with changing environments.
    Type of Medium: Online Resource
    Pages: VII, 199 p. 37 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030971892
    Series Statement: Coral Reefs of the World, 14
    DDC: 577.6
    Language: English
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    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Biodiversity. ; Zoology. ; Molecular ecology. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Biodiversity. ; Zoology. ; Molecular Ecology.
    Description / Table of Contents: Introduction to Coral Reef Conservation and Restoration in the Omics Age -- Incorporating Genetic Measures of Connectivity and Adaptation in Marine Spatial Planning for Corals -- Maximizing Genetic Diversity in Coral Restoration Projects -- Identifying, Monitoring, and Managing Adaptive Genetic Variation in Reef-Building Corals Under Rapid Climate Warming -- Selective Breeding to Enhance the Adaptive Potential of Corals -- Coral Conservation from the Genomic Perspective on Symbiodiniaceae Diversity and Function in the Holobiont -- Dynamics of Bacterial Communities on Coral Reefs: Implications for Conservation -- Increasing Coral thermal Bleaching Tolerance via the Manipulation of Associated Microbes -- Epigenetics and Acquired Tolerance to Environmental Stress -- Can Gene Expression Studies Inform Coral Reef Conservation and Restoration? -- A Need for Reverse Genetics to Study Coral Biology and Inform Conservation Efforts -- Informing Coral Reef Conservation Through Metabolomic Approaches -- Environmental DNA for Biodiversity Monitoring of Coral Reefs -- Cryopreservation to Conserve Genetic Diversity of Reef-Building Corals -- Synthesis: Coral Reef Conservation and Restoration in the Omics Age.
    Abstract: The rapid demise of coral reefs worldwide has spurred efforts to develop innovative conservation and restoration methods. Many of these rely on omics approaches to produce genetic, genomic, transcriptomic, epigenomic or metabolomic data to inform conservation and restoration interventions. This book provides the state of play of this field. It discusses topics ranging from how genomic and environmental DNA (eDNA) data can be used to inform marine protected area design and cryopreservation strategies, the use of knowledge on adaptive genetic and epigenetic variation to maximise environmental stress tolerance of coral stock, harnessing transcriptome data to develop early warning markers, the use of microbial symbiont omics data in guiding restoration strategies, to applications of metabolomics and genetic engineering. How best to translate omics data to resource managers is also discussed.
    Type of Medium: Online Resource
    Pages: VIII, 242 p. 48 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031070556
    Series Statement: Coral Reefs of the World, 15
    DDC: 577.6
    Language: English
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Freshwater ecology. ; Marine ecology. ; Food security. ; Bioclimatology. ; Oceanography. ; Freshwater and Marine Ecology. ; Food Security. ; Climate Change Ecology. ; Ocean Sciences.
    Description / Table of Contents: 1. Introduction -- 2. Overview of the Marine Environment -- 3. Shoaling and migration of fish and their relationships with environment -- 4. Basic Theories of Formation of Fishing ground -- 5. Basic Principles and Methods of Fisheries Forecasting -- 6. Case Studies of Fisheries Forecasting -- 7. Effects of Global climate Changes on Marine Fishery Resources.
    Abstract: This book systematically introduces the knowledge system and research results of fisheries forecasting. It is divided into four parts and seven chapters. The first part is the introduction, which mainly introduces the basic concepts, the nature of the subject, and the research contents, as well as the current status of research. The second part is about the basic knowledge of fisheries forecasting, including overview of the world marine environment, fish shoaling and migration distribution, the relationship between fish behavior and marine environment, and the basic theory of forming fishing ground. The third part is the focus of this book, including the basic principles and methods of fisheries forecasting, as well as the application of new techniques and methods in fisheries forecasting. The fourth part is the comprehensive application of fisheries forecasting, including the general situation of world marine fisheries, the impact of global marine environment changes on fisheries resources and fishing ground, and case studying of fisheries forecasting of important economic species, such as oceanic squid, jack mackerel, anchovy, and skipjack. The study of this book will help everyone to master the basic principles and methods of fisheries forecasting, as well as the application of new technologies and methods in important economic species, and lay a foundation for future work in the field of marine fisheries.
    Type of Medium: Online Resource
    Pages: XIV, 199 p. 24 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811929564
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Tumor markers. ; Cancer. ; Cancer Treatment. ; Nanomedicine. ; Tumour Biomarkers. ; Cancer Biology. ; Cancer Therapy. ; Cancer Nanotechnology.
    Description / Table of Contents: Chapter 1. Introduction to cancer biomarkers -- Chapter 2.Technologies for identification and validation of cancer biomarkers -- Chapter 3. BIOMARKERS FOR CANCER DRUG DEVELOPMENT -- Chapter 4. Clinical proteomics: diagnostics and prognostic markers of Cancer -- Chapter 5.Microbiome as cancer biomarkers -- Chapter 6. Predictive biomarkers for anticancer drugs -- Chapter 7. Biomarkers in Cancer Survival and Drug Resistance -- Chapter 8. Biomarkers in tumor recurrence and metastasis -- Chapter 9. Biomarkers for Cancer Immunotherapy -- Chapter 10. Role of Biomarkers in Personalized Medicine -- Chapter 11.Development of Novel Cancer Biomarkers for Diagnosis and Prognosis -- Chapter 12. Nanotechnology for Cancer Biomarkers.
    Abstract: This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.
    Type of Medium: Online Resource
    Pages: XII, 365 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811657597
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Biochemical markers. ; Microfluidics. ; Pharmacology. ; Cancer Treatment. ; Cancer Biology. ; Biomarkers. ; Microfluidics. ; Pharmacology. ; Cancer Therapy.
    Description / Table of Contents: Part 1. Fundamentals of Microfluidics and Biosensors -- Chapter 1. Fundamentals of Biosensors and Detection Methods -- Chapter 2. How to Get Away with Gradients -- Chapter 3. Sensors and Biosensors in Organs-on-a-chip Platforms -- Chapter 4. Current Trends in Microfluidics and Biosensors for Cancer Research Applications -- Part 2. Modelling the Tumor Microenvironment and Its Dynamic Events -- Chapter 5. The Tumor Microenvironment — an Introduction for the Development of Microfluidic Devices -- Chapter 6. Biomaterials for Mimicking and Modelling Tumor Micro-environment -- Chapter 7. Advancing Tumor Microenvironment Research by Combining Organs-on-chips and Biosensors -- Chapter 8. Microfluidic-driven Biofabrication and the Engineering of Cancer-like Microenvironments -- Chapter 9. Advances in 3d Vascularized Tumor-on-a-chip Technology -- Part 3. Cancer Detection and Diagnosis -- Chapter 10. Biosensors Advances: Contributions to Cancer Diagnostics and Treatment -- Chapter 11. Flexible Sensing Systems for Cancer Diagnostics -- Chapter 12. Coupling Micro-physiological Systems and Biosensors for Improving Cancer Biomarkers Detection -- Chapter 13. Microfluidic Biosensor-based Devices for Rapid Diagnosis and Effective Anti-cancer Therapeutic Monitoring for Breast Cancer Metastasis -- Chapter 14. Liquid Biopsies: Flowing Biomarkers -- Chapter 15. From Exosomes to Circulating Tumor Cells: Using Microfludics to Detect High Predictive Cancer Biomarkers -- Chapter 16. Microfluidics for the Isolation and Detection of Circulating Tumor Cells -- Chapter 17. Evolution in Automatized Detection of Cancer Cells: Advances in Magnetic Microcytometers -- Chapter 18. Droplet-based Microfluidic Chip Design, Fabrication and Use for Ultrahigh-throughput DNA Analysis and Quantification -- Chapter 19. Emerging Microfluidic and Biosensor Technologies for Improved Cancer Theranostics -- Part 4. Clinical Applications: Towards Personalized Medicine -- Chapter 20. Microfluidics for Cancer Biomarker Discovery, Research and Clinical Application -- Chapter 21. Methods for the Detection of Circulating Biomarkers in Cancer Patients -- Chapter 22. Advances in Microfluidics for the Implementation of Liquid Biopsy in Clinical Routine.
    Abstract: This book offers a comprehensive overview of the development and application of microfluidics and biosensors in cancer research, in particular, their applications in cancer modeling and theranostics. Over the last decades, considerable effort has been made to develop new technologies to improve the diagnosis and treatment of cancer. Microfluidics has proven to be a powerful tool for manipulating biological fluids with high precision and efficiency and has already been adopted by the pharmaceutical and biotechnology industries. With recent technological advances, particularly biosensors, microfluidic devices have increased their usefulness and importance in oncology and cancer research. The aim of this book is to bring together in a single volume all the knowledge and expertise required for the development and application of microfluidic systems and biosensors in cancer modeling and theranostics. It begins with a detailed introduction to the fundamental aspects of tumor biology, cancer biomarkers, biosensors and microfluidics. With this knowledge in mind, the following sections highlight important advances in developing and applying biosensors and microfluidic devices in cancer research at universities and in the industry. Strategies for identifying and evaluating potent disease biomarkers and developing biosensors and microfluidic devices for their detection are discussed in detail. Finally, the transfer of these technologies into the clinical environment for the diagnosis and treatment of cancer patients will be highlighted. By combining the recent advances made in the development and application of microfluidics and biosensors in cancer research in academia and clinics, this book will be useful literature for readers from a variety of backgrounds. It offers new visions of how this technology can influence daily life in hospitals and companies, improving research methodologies and the prognosis of cancer patients.
    Type of Medium: Online Resource
    Pages: XIX, 590 p. 100 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031040399
    Series Statement: Advances in Experimental Medicine and Biology, 1379
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Ecology . ; Zoology. ; Nutrition   . ; Freshwater and Marine Ecology. ; Ecology. ; Zoology. ; Zoology. ; Nutrition.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Protein Requirement -- Chapter 3. Utilization of Proteinaceous Nutrients -- Chapter 4. Peptides or Amino Acids? -- Chapter 5. Amino Acid Functions and Requirements -- Chapter 6. Simple Amino Acids: Gly, Ala, Asp, Gln -- Chapter 7. The Versatile Amino Acid: Tryptophan -- Chapter 8. A Bunch of Amino Acids: Phe, Tyr, Branched-Chain AAs, Ser, Thr -- Chapter 9. Sulfur Amino Acids -- Chapter 10. Basic Amino Acids and Prolines -- Chapter 11. Taurine -- Chapter 12. Nonprotein Amino Acids -- Chapter 13. Glucose -- Chapter 14. Glucose Homeostasis -- Chapter 15. Glucose Intolerance -- Chapter 16. Carbohydrate Transport -- Chapter 17. Protein Sparing by Carbohydrates -- Chapter 18. Carbohydrate Preference and Metabolism -- Chapter 19. Regulatory Potential of Carbohydrates -- Chapter 20. Oligosaccharides -- Chapter 21. Starch -- Chapter 22. Non-Starch-Polysaccharides & Fibers -- Chapter 23. Lipids -- Chapter 24. Lipid Homeostasis -- Chapter 25. Protein Sparing by Lipids -- Chapter 26. Fatty Acids -- Chapter 27. Essential Fatty Acids -- Chapter 28. Biosynthesis of Polyunsaturated Fatty Acids -- Chapter 29. PUFAs in Reproduction and Behavior -- Chapter 30. Trophic Transfer of PUFAs -- Chapter 31. Sterols, Phospholipids, Wax Esters -- Chapter 32. Vitamin A -- Chapter 33. Vitamin B -- Chapter 34. Vitamin C -- Chapter 35. Vitamin D -- Chapter 36. Vitamin E -- Chapter 37. Vitamin K -- Chapter 38. Nucleotides -- Chapter 39. Exogenous Enzymes -- Chapter 40. Intraspecific Variability.
    Abstract: As sequel to Aquatic Animal Nutrition – A Mechanistic Perspective from Individuals to Generations, the present treatise on organic macro- and micronutrients continues the unique cross fertilization of aquatic ecology/ecophysiology and aquaculture. This treatise considers proteins and their constituents, carbohydrates from mono- to polysaccharides, fatty acids from free acids to fat, and waxes. It becomes obvious that these organic nutrients are more than only simple fuel for the metabolism of animals; rather, their constituents have messenger and controlling function for the actual consuming individual and even for succeeding generations. This aspect will become particularly clear by putting the organisms under consideration back into their ecosystem with their interrelationships and interdependencies. Furthermore, micronutrients, such as vitamins and nucleotides as well as exogenous enzymes, are in the focus of this volume with known and still-to-be-discovered controlling physiological and biomolecular functions. Aquatic Animal Nutrition – Organic Macro and Micro Nutrients addresses se­veral gaps in nutritional research and practice. One major gap is the lack of com­mon research standards and protocols for nutritional studies so that virtually incomparable approaches have to be compared. This applies also to the studied animals, since most approaches disregard intraspecific variabilities and the existence of epimutations in farmed individuals. Furthermore, recalling the Mechanistic Perspective from Individuals to Generations, dietary benefits and deficiencies have effects on succeeding generations. In most studies, this long-term and sustainable aspect is overruled by pure short-term production aspects. By comparing nutritional behavior and success of fishes and invertebrates, Aqua­tic Animal Nutrition points out different metabolic pathways in these animal groups and discusses how, for instance, fishes would benefit when having some successful metabolic pathway of invertebrates. Application of novel ge­ne­tic techniques will help turn this vision into reality. However, a widely missing link in the current nutritional research is epigenetics regarding transgenerational heritages of acquired morphological and physiological properties. To in­crease public acceptance, nutritional optimization of farmed animals based on this mechanism, rather than genetical engineering, appears promising.
    Type of Medium: Online Resource
    Pages: XVI, 1084 p. 358 illus., 199 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030872274
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Sustainability. ; Freshwater and Marine Ecology. ; Sustainability.
    Description / Table of Contents: Diagnosing the Problem -- Cultivate Shellfish to Remediate the Atmosphere -- Aquaculture: Prehistoric to Traditional to Modern -- The High Seas Solution -- Farming Giant Clams in 2021: a Great Future for the ‘Blue Economy’ of Tropical Islands -- Coccolithophore Cultivation and Deployment -- Comparing industrial and biotechnological solutions for carbon capture and storage -- What should be done.
    Abstract: This book presents a solutions based approach to reducing and removing CO2 from the atmosphere transforming it into solid (crystalline) CaCO3 through the ability of marine organisms such as molluscs, crustacea, corals, and coccolithophore algae. The overwhelming advantage of this approach is that it promises enhanced climate mitigation in comparison to planting forests, industrial/engineering carbon capture and storage process. It also provides a sustainable food resource. Furthermore, it would improve the ocean's biodiversity at the same time as the excess atmospheric CO2 released by our use of fossil fuels is returned to the place it belongs - as a present day fossil, safely out of the atmosphere to the distant future. If the level of finance and global effort that are readily foreseen for forest management and flue gas treatments were applied to expansion of global shellfish cultivation, curative amounts of carbon dioxide could be permanently removed from the atmosphere within a few decades. The concept presented in this book could have a profound influence on the life of the planet.
    Type of Medium: Online Resource
    Pages: XVII, 253 p. 69 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030948467
    Series Statement: Sustainable Development Goals Series,
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Freshwater ecology. ; Marine ecology. ; Oceanography. ; Biotic communities. ; Population biology. ; Freshwater and Marine Ecology. ; Ocean Sciences. ; Community and Population Ecology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Fish Stocks and Discriminant Methods -- Chapter 3. Life History and Early Development of Fishes -- Chapter 4. Age and growth of fish -- Chapter 5. Sexual maturation, reproductive habits and fecundity of fish -- Chapter 6. Fish prey, food habits and interspecific relationships -- Chapter 7. Fish schooling and migration.
    Abstract: This auto-translation book overviews the fish population and its research methods, help readers in understanding the concept of fish population and population identification. It divides into seven chapters according to the characteristics of the subject and the development results. Based on a systematic introduction to the basic concepts and research contents of the biology of fishery resources, the book focuses on the introduction of fish populations and research methods, life history division and early development identification, age identification and growth research, the division of sexual maturity, the determination of reproductive habits and fecundity, feeding characteristics and research methods of fish, and the mechanism of fish colony and migration. Through the study of this course, we can master the basic theory and methods of fish biology research and lay a solid foundation for future researches on fishery resources. This book can be used as a reference book for undergraduates and postgraduates who study fishery resources, as well as for those who are engaged in fishery and marine research. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content.
    Type of Medium: Online Resource
    Pages: IX, 186 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811669484
    DDC: 577.6
    Language: English
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    Keywords: Cancer. ; Tumors Blood-vessels. ; Blood-vessels Growth. ; Cancer Imaging. ; Cancer Genetic aspects. ; Cancer Biology. ; Tumour Angiogenesis. ; Cancer Imaging. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Part I: Basic Background -- Chapter 1. Fighting with Cancer: A Common Man’s Dilemma -- Chapter 2. Introduction to Cell Biology and Cell Behavior in Cancer -- Chapter 3. Tumor Biology: An Introduction -- Chapter 4. Role of Angiogenesis in Tumours -- Chapter 5. Biology, Chemistry and Physics of Cancer Cell Motility and Metastasis -- Part II: Diagnostics and Theory -- Chapter 6. MRI, CT and PETSCAN: Engineer’s Perspective -- Chapter 7. Diffusion, MRI and Cancer Diagnosis: Physicist’s Outlook -- Chapter 8. Oncology: Radiation Oncologist’s View -- Chapter 9. Oncology: Biochemists’ Perspective -- Chapter 10. Oncology: Pathologist’s View -- Part III: Cancer Therapeutics -- Chapter 11. Surgical Oncology: An Overview -- Chapter 12. Medical Oncology in Cancer Treatment -- Chapter 13. Chemotherapy Effects on Immune System -- Chapter 14. Telomerase and its therapeutic implications in Cancer -- Chapter 15. Pain Management in Oncology -- Part IV: Emerging Trends in Cancer Research -- Chapter 16. New Approaches in Cancer Research: Stem-cell research, Translational Research, Immuno-therapy, and others -- Chapter 17. Cancer Cell Lines: Its Implication for Therapeutic Use -- Chapter 18. Genomics of Cancer -- Chapter 19. Chapter 19: Diabetes and Cancer -- Chapter 20. Oncology Informatics, AI, and Drug Discovery -- Chapter 21. Radiomics: Cropping More from the Images -- Part V: Epidemiology and Statistics of Cancer -- Chapter 22. Statistics in Cancer: Diagnosis, Disease Progression, Treatment Efficacy and Patient Survival Studies -- Chapter 23. Epidemiology of Cancer: Asian Perspective -- Chapter 24. Cancer Genomics and Diagnostics: Northeast Indian Scenario.
    Abstract: This book presents multiple facets of cancer biology, including cancer diagnosis, therapeutics to the latest developments in cancer informatics, and applications of artificial intelligence for improving oncologic care. The initial section of the book discusses factors contributing to the development and causes of cancer. The subsequent sections discuss the basic principle of imaging and therapeutic techniques, including MRI, CT, and positron emission tomography (PET) Scan. The book further, explores the implications of cancer chemotherapy on the immune system and emphasizes the effective management of cancer-related pain. Towards the end, it covers recent advancements in cancer treatment, including targeted therapy, immunotherapy, interventional radiotherapy, and stem cell-based therapy. Lastly, it summarizes essential strategic elements of cancer informatics for improving patient outcome.
    Type of Medium: Online Resource
    Pages: XIX, 529 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811647529
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Ethnology. ; Biotechnology. ; Biotic communities. ; Environmental policy. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Ethnology. ; Biotechnology. ; Ecosystems. ; Environmental Policy.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. History of Hinase -- Chapter 3. Eelgrass Restoration -- Chapter 4. Living on the Coast -- Chapter 5. Social Network and Ideas Concerning the Restoration Activity -- Chapter 6. The Sun is Born.
    Abstract: This book explores the nature of marine conservation based on the case study of Hinase, a fishing village in Okayama, Japan. It focuses on the fishers’ self-motivated eelgrass restoration activity which has been continued for more than 30 years. This activity in Hinase recently attracted international attention as a case under the name “Satoumi” and “Marine Protected Areas” in several governmental reports, but detailed information, such as the historical background and social structure of Hinase, has not yet been analyzed. This book, therefore, fulfills this gap by providing its ethnographic information. In addition, this book offers some points for critical thinking by concluding that marine conservation activities cannot always be evaluated or arranged under the standardized approach with limited time and space. This viewpoint reaffirms the importance of local initiative and highlights the value of qualitative research to seek the way forward for promising marine conservation. This book is suitable for an academic audience in the field of social sciences, such as applied anthropology, as well as ecologists, government officials, environmentalists, and citizens who are interested or engaged in environmental issues or natural resource management.
    Type of Medium: Online Resource
    Pages: XX, 155 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811904561
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Behavior genetics. ; Zoology. ; Biodiversity. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Behavioral Genetics. ; Ecology. ; Zoology. ; Biodiversity.
    Description / Table of Contents: What can we infer about the behavior of extinct sirenians -- Sensory and morphological adaptation for an aquatic lifestyle -- Diving and foraging behaviors. Lucy Keith-Diagne, African Aquatic Conservation Fund -- Movement behaviors. Chip Deutsch, Associate Research Scientist, Florida Fish and Wildlife Conservation Commission -- Historical and current interactions with humans from the perspective of sirenian ethology and behavioral ecology -- Likely impacts of climate change on sirenian behavior -- Implications of sirenian behavior for conservation and management.
    Abstract: Despite their rich fossil history, there are only four surviving species of sirenians or sea cows, the only fully aquatic herbivorous mammals. The three species of manatees and the dugong live in the coastal waters rivers and lakes of more than 80 tropical and subtropical countries and are all on the IUCN Red List of Threatened Species. This book examines sirenian conservation biology through the lens of their behavioral ecology and ethology. Sirenian feeding, diving, movement, social and reproductive behaviors are reviewed by an international team of scientists from eight countries, with an emphasis on data gathered in the past 15 years. .
    Type of Medium: Online Resource
    Pages: XVI, 417 p. 62 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030907426
    Series Statement: Ethology and Behavioral Ecology of Marine Mammals,
    DDC: 577.6
    Language: English
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    Keywords: Freshwater ecology. ; Marine ecology. ; Water. ; Hydrology. ; Environmental management. ; Environment. ; Freshwater and Marine Ecology. ; Water. ; Environmental Management. ; Environmental Sciences.
    Description / Table of Contents: Chapter 1: Introduction Nature-based solutions for urban water management: challenges and opportunities in the context of Asia -- Chapter 2: Types of Nature-based Solutions for water, their functions and suitability -- Chapter 3: Constructed floating wetlands for the treatment of surface waters and industrial wastewaters -- Chapter 4: Nature based solutions for water management in England: contribution to biodiversity net-gain in urban areas -- Chapter 5: Applications of Nature-based Solutions in Urban Water Management in Singapore, Thailand and Viet Nam, a review -- Chapter 6: Wastewater pollution in urban canals of Vietnam: Restoration using nature-based solutions -- Chapter 7: Nature-based solutions for domestic wastewater treatment in the Philippines -- Chapter 8: Application of Floating Wetlands as a Nature Based Solution for Water Reclamation of Urban Lakes in Sri Lanka and Development of an Appropriate Assessment Criterion -- Chapter 9: Role of Information and Communication Technology (ICT) in following Global Standard for NbS: The Bangladesh Perspective.
    Abstract: Nature-based solutions (NbS) are solutions inspired or supported by nature. They include ecosystem conservation and restoration measures, as well as the creation or enhancement of natural processes in man-made ecosystems, such as cities. Recent interest in NbS has emphasized their importance for urban water management and cities across the world have begun to experiment with them. Experiences from different contexts, however, are not adequately captured and understood. This book aims to address this gap by compiling case studies and reviews that explore NbS for urban water management from different regions and perspectives and highlight emerging challenges and opportunities for harnessing their potential. .
    Type of Medium: Online Resource
    Pages: XXII, 247 p. 78 illus., 74 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031184123
    Series Statement: Applied Environmental Science and Engineering for a Sustainable Future,
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Bioinformatics. ; Immunology. ; Cancer Biology. ; Computational and Systems Biology. ; Immunology.
    Description / Table of Contents: 1. Introduction: Introduction of lipids, lipid metabolism and tumor immunity -- 2. ipid metabolism and lipidomics -- 3. Applications of lipidomics in tumour immunity.-4. Overview: Lipid metabolism in tumour microenvironment -- 5. Lipid metabolism in cancer cells -- 6. Lipid metabolism in tumour-associated NK -- 7. Lipid metabolism in tumour-associated macrophages -- 8. Lipid metabolism in tumour-associated MDSCs -- 9. Lipid metabolism in tumour-associated fibroblasts -- 10. Lipid metabolism in tumour-associated B cells -- 11. Lipid metabolism in tumour-infiltrating T cells -- 12. Lipid metabolism and angiogenesis -- 13. Lipid metabolism and tumor antigen-presenting -- 14. Lipid metabolism and immune checkpoints.
    Abstract: This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery. .
    Type of Medium: Online Resource
    Pages: XI, 211 p. 24 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813367852
    Series Statement: Advances in Experimental Medicine and Biology, 1316
    DDC: 571.978
    Language: English
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    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Biodiversity. ; Animal migration. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Biodiversity. ; Animal Migration.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. European pearl mussel: background information and literature review -- Chapter 3. Materials and methods -- Chapter 4. Results -- Chapter 5. Discussion -- Chapter 6. Conclusions.
    Abstract: The monograph focuses on the European freshwater pearl mussel Margaritifera margaritifera, which is an endangered bivalve species. Most of its populations in the Russian section of the Baltic Sea basin had never been studied, although they were known in the past to the pearl fishers. “Rediscovery” included search for the previously unknown populations, revealing the facts of population extinctions, analysis of negative impacts, elaboration of conservation measures, and revealing of regularities in distribution. Patterns of land use and river management were analyzed. The procedure of “rediscovery” was applied for other animal species of Northwest Russia, which are threatened on a global scale – thick-shelled mussel, Unio crassus; curlew Numenius arquata; black-tailed godwit, Limosa limosa; Northern Lapwing, Vanellus vanellus; European mink, Mustela lutreola; pond bat, Myotis dasycneme; Atlantic sturgeon, Acipenser sturio; and broad-clawed crayfish, Astacus astacus. The methods and principles of conservation studies were discussed. The obtained data were analyzed with respect to current global change of biosphere. The book will appeal to specialists dealing with conservation studies and activities such as red lists, river protection, and conservation of endangered species. Moreover, a part of the book represents an interest for biogerontology as it presents discredit of the popular concept on “negligible senescence.” The data on distribution of some animals in Russia will be interesting in terms of zoology and biogeography, as they are not yet sufficiently represented in the international editions. The book can be used as supplemental reading for courses in biological invasions, ecology and conservation, and biodiversity. The work also contains chapters on global processes (deforestation, desertification, river degradation) and can therefore also be used for general courses in environmental sciences.
    Type of Medium: Online Resource
    Pages: XI, 246 p. 88 illus., 87 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030662554
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Biophysics. ; Cell interaction. ; Cytology. ; Cancer Microenvironment. ; Mechanobiological Cell Signaling. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 191 p. 31 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030471897
    Series Statement: Advances in Experimental Medicine and Biology, 1270
    DDC: 571.978
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Genetics. ; Molecular biology. ; Cancer Biology. ; Genetics and Genomics. ; Molecular Biology.
    Description / Table of Contents: 1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies.
    Abstract: Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.
    Type of Medium: Online Resource
    Pages: XVII, 167 p. 72 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030756994
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Diseases. ; Immunology. ; Bioinformatics. ; Cancer Biology. ; Diseases. ; Immunology. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Obesity induced chronic low-level inflammation and cancers -- Chapter 2. Adipose tissue produced estrogen as risk factor for cancers -- Chapter 3. Insulin and Insulin-like growth factor-1 associated cancers.-Chapter 4. Adipokines play important role in cell proliferation and antiproliferation -- Chapter 5. mTOR and AMP-activated protein kinase in obesity and cancer -- Chapter 6. Immune response and oxidative stress in obesity induced cancer -- Chapter 7. Role of gene polymorphism in obesity and cancer -- Chapter 8. Therapeutic role of green tea in obesity and cancer -- Chapter 9. Effect of dietary phytochemicals in obesity and cancer -- Chapter 10. Resveratrol as anti-obesity and anticancer agent -- Chapter 11. EGCG as anti-obesity and anticancer agent -- Chapter 12. miRNAs as therapeutic target in obesity and cancer -- Chapter 13. In silico updates on lead identification for obesity and cancer -- Chapter 14. In vivo models for obesity and obesity related carcinogenesis -- Chapter 15. Estrogen signaling based current and potential therapies against obesity and related diseases -- Chapter 16. Autophagy at the crossroad of obesity mediated cancer progression.
    Abstract: This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry. .
    Type of Medium: Online Resource
    Pages: IX, 361 p. 38 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811618468
    DDC: 571.978
    Language: English
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  • 79
    Keywords: Cancer. ; Biomedical engineering. ; Biochemical markers. ; Nanomedicine. ; Cancers. ; Biomedical Engineering and Bioengineering. ; Biomarkers. ; Cancer Nanotechnology.
    Description / Table of Contents: Chapter 1. Cancer of the Skin:Type and Etiology -- Chapter 2. Therapeutic intervention in skin cancer: Future prospects -- Chapter 3. Melanin Based Classification of Skin Types and Their Susceptibility to UV-induced Cancer -- Chapter 4. The Epidemiology of Skin Cancer Worldwide -- Chapter 5. UV-R induced Vitamin D synthesis and skin cancer -- Chapter 6. The role of microbiome in the induction, diagnosis and therapy of skin cancer -- Chapter 7. Skin Cancer: Molecular Biomarker for Diagnosis, Prognosis, Prevention and Targeted Therapy -- Chapter 8. Therapeutics intervention of skin cancer in the OMICS era -- Chapter 9. Artificial intelligence in Skin Cancer: Diagnosis and Therapy -- Chapter 10. Biomedical engineering in cancer diagnosis and therapy -- Chapter 11. Skin cancer treatment with Emphasis on Nanotechnology -- Chapter 12. Non-long coding RNA and role in skin cancer diagnosis and therapy -- Chapter 13. Potential of long non-coding RNAs in the diagnosis and therapy of melanoma skin cancer.-.
    Abstract: This book highlights the molecular and cellular mechanisms involved in the initiation and progression of skin cancer. It also explains the role of the environment in skin cancer development and explores the potential of microbiome in the diagnosis, prevention and treatment of skin cancer. The book also presents potential biomarkers for early detection of skin cancer and discusses recent advances in skin cancer prevention and treatment using photodynamic therapy. Lastly, it summarizes the applications of biomedical engineering, non-coding and nanotechnology in the diagnosis and therapeutics in skin cancer. It is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, and dermatologists.
    Type of Medium: Online Resource
    Pages: VIII, 250 p. 27 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811603648
    DDC: 571.978
    Language: English
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  • 80
    Keywords: Cancer. ; Genetics. ; Medical genetics. ; Cancers. ; Genetics and Genomics. ; Medical Genetics. ; Cancer Biology.
    Description / Table of Contents: Chapter 1. Polymorphisms and Mutation: What is difference? -- Chapter 2. Single nucleotide polymorphisms and pharmacogenomics -- Chapter 3. Impact of MicroRNA Polymorphisms on Breast Cancer Susceptibility -- Chapter 4. From inflammation to cancer: Role of genetic polymorphisms of Inflammatory Pathway Molecules in Gastric Cancer -- Chapter 5. Colorectal Cancer and genetic polymorphism in key regulatory low penetrance genes -- Chapter 6. Role of Genetic Polymorphisms in Breast Cancer -- Chapter 7. Genetic Polymorphisms of Essential Immune Pathogenic Response Genes and Risk of Cervical Cancer -- Chapter 8. Thyroid Cancer and genetic polymorphism -- Chapter 9. SNPs of TLRs and Bladder Cancer -- Chapter 10. Role of genetic polymorphisms in Lung Cancer.
    Abstract: This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.
    Type of Medium: Online Resource
    Pages: XXI, 339 p. 48 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813366992
    DDC: 571.978
    Language: English
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  • 81
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Biology. ; Cancer Treatment. ; Biotechnology. ; Molecular biology. ; Physiology. ; Cancer Biology. ; Biological Sciences. ; Cancer Therapy. ; Biotechnology. ; Molecular Biology. ; Physiology.
    Description / Table of Contents: Chapter 1. Introduction to Dietary Research and Cancer -- Chapter 2. Healthy Dietary Patterns and Cancer -- Chapter 3. Frequently Asked Diet and Nutrition Related Questions by Cancer Survivors -- Chapter 4. Dietary Recommendations of Worldwide Cancer Related Organizations -- Chapter 5. Outcome of ‘Diet and Cancer’ Related Clinical Trials -- 6. Diet and Cancer Epigenetics: A Step Towards Developing Cancer Epigenetic Diet -- 7. Role of Dietary Ingredients on Expression of Oncogenic and Tumor Suppressor miRNA -- 8. Can Diet Influence Metastasis? -- 9. Impact of Dietary Interventions on Cancer Stem Cells -- 10. Interaction of Dietary Metabolites with Anti-cancer Drug Targets -- 11. Revisiting the Anticancer Drug-Food Interactions -- 12. Functional Foods, Nutraceuticals, and Dietary Supplements in Cancer Prevention -- 13. Do Antioxidants Really Help Cancer Patients? The Puzzle of Benefits and Perils -- 14. Market of Dietary Supplements: Analysis of Health Benefits and Risk in Cancer -- 15. Cancer and Fasting: Can Fasting/Calorie Restriction (CR) or Fasting Mimicking Diet (FMD) Helps Fight Cancer? Molecular Basis of Fasting Response -- 16. Do Fasting, CR, and FMD Improves the Chemotherapy Response, Reduce Off Target Toxicities and Enhance Antitumor Immunity? Illusion or Clinical Reality? -- 17. Future Prospectus of Dietary Interventions in the Integrated Management of Cancer.
    Abstract: This book reviews all important aspects of dietary research associated with cancer with the aim of shedding new light on these conditions through combined understanding of traditional and new paradigms. The book is divided into 17 chapters, the first portion reinterprets healthy diets for cancer based on up-to-date evidence from a network science perspective, examining the dietary patterns, outcome of diet related clinical trials, emerging framework of molecular mechanisms and interactions of dietary interventions and their applications in personalized diet, ground realities of benefits and regulatory frame work for functional foods, nutraceuticals and supplements in cancer prevention and upcoming future prospectus in diet-cancer research.. The later part of the book discusses recent advances in understanding of the elaborative discourse on cancer and fasting, covering, for example, calorie restriction and fasting mimicking diet. Finally, different Dietary research and approaches are considered in the context of novel intervention for cancer research. Dietary Research in Cancer will be of interest for all researchers, nutritionists, students and clinicians in the field.
    Type of Medium: Online Resource
    Pages: XX, 197 p. 57 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811660504
    DDC: 571.978
    Language: English
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  • 82
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Biotic communities. ; Landscape ecology. ; Water. ; Hydrology. ; Biodiversity. ; Conservation biology. ; Ecology . ; Freshwater and Marine Ecology. ; Ecosystems. ; Landscape Ecology. ; Water. ; Biodiversity. ; Conservation Biology.
    Description / Table of Contents: Introduction -- Part I. Historical Perspectives -- Vertebrates of Upper Mesopotamia: Present Evidence and Archaeological Data -- Fishing Gears and Methods: A Comparison of Ancient Mesopotamia and Other Ancient Worlds -- Ichthyological Characteristics Available in the Fish Images Existed in the Art of the Ancient Mesopotamia -- The Effectiveness of Ancient Mesopotamian Medical Practices: The Example of šūšu-Licorice -- Part II. The Abiotic Aspects of the Tigris–Euphrates River System -- Management of Water Resources Using Storage Reservoirs -- Estimation of Irrigated Agricultural Area and Water Consumption in Iraq -- The Nature of Tigris–Euphrates Rivers Flow: Current Status and Future Prospective -- Streamflow Alteration Impacts with Particular Reference to the Lower Zab River, Tributary of the Tigris River -- Ecohydrology in Iraq: Challenges and its Future Pathways -- Oil Pollution in the Shatt Al-Arab River and its Estuary 1980–2018 -- Pesticides in the Waters, Sediments, and Biota of the Shatt Al-Arab River for the Period 1980–2017 -- Surface Water Salinity of the Euphrates, Tigris, and Shatt al-Arab Rivers -- Renewable Energy for Water–Energy Nexus in Euphrates and Tigris River Basin: A Literature Review -- Impacts of Dams on Aquatic Biodiversity, Fisheries, Fishes and Their Environment: Problems that Could Be Present in Iraq with Recommendations -- Water, Politics and Dams in the Mesopotamia Basin of the Northern Middle East: How Turkey Instrumentalises the South-Eastern Anatolia Project for Political, Military and Strategic Interests -- Dams and their Impacts on Fishes in Iran -- Part III. The Biotic Aspects of the Tigris–Euphrates River System -- Preliminary Review of the Aquatic Biodiversity in Al-Kahla River, Missan Province, Iraq -- Freshwater Fish Biodiversity in Iraq: Importance, Threats, Status, and Conservation Challenges -- Effect of Climate Changes on the Freshwater Biodiversity in the Mesopotamian Plain: Recommendations for Avoidance and Plans for the Future -- River Corridors as a Refuge for Freshwater Biodiversity: Basic Information and Recommendations to the Policymakers for Possible Implications in Iraq -- Biodiversity of Fungi in Aquatic Environment of Iraq -- Potability of Drinking Water in Basra-Iraq -- Algal Studies in Iraqi Inland Waters. A Review -- The Distribution of Epilitic Diatoms in the Turkish Part of the Tigris-Euphrates River Basin -- Plant Biodiversity in Shatt Al-Arab Estuary and Ecological Variations -- Medicinal Plants of Shatt al-Arab River and Adjacent Area -- The Role of Plants as a Canopy in the Inland Waters: Basic Information for Application in Iraq -- The Zooplankton Fauna of the Turkish Part of the Euphrates-Tigris River Basin -- Kinds and Distribution of Icthyoplankton in Shatt Al-Arab River -- Rotifer Diversity in Iranian Waters: A Review -- Biodiversity of the Freshwater Amphipods in Iran -- The Freshwater Molluscs of the Mesopotamian Plain -- Freshwater Annelida of Iraq -- A Critical Checklist of the Inland Fishes Native to the Euphrates and Tigris Drainages -- Fish Fauna of Shatt al-Arab River, Basrah, Iraq: A More than Quarter a Century of Changes -- The Common Carp, Cyprinus carpio: Effect on the Environment and the Indigenous Fish Species in Iraq -- The Good and the Bad in Releasing the Grass Carp Ctenopharyngodon idella in the Freshwater System: Recommendations for the Policymakers in Iraq -- The Avifauna of Tigris and Euphrates River Basin -- The Feasible Approaches to Assist Migratory Birds Visiting the Southern Reaches of Mesopotamia -- A Proposal for Establishing Bird Observatory Centre in the South of Iraq -- The Potential Role of Waterbirds as a Vector in Dispersing Invertebrates and Plants in the South of Iraq -- The Wild Mammals of the Tigris and Euphrates Rivers Basin -- The Amphibians and Reptiles of Euphrates and Tigris Basin -- A Preliminary Pictorial Guide to the Herpetofauna of Tigris and Euphrates River Basin -- Policy Guidance for Sustainable Aquaculture in the Inland Waters of Iraq -- How Possible to Use the Desert Area in Iraq for Aquaculture Industry: Basic Facts and Recommondations -- Aquaculture Industry in Iraq: Past, Present, and Future Perspectives -- Towards an Improved Tilapia Farming in Iraq: Recommendations for Future Application -- Information and Recommendations of Aquaculture Stress and its Source in Hatcheries: The Iraqi Aquaculture Industry Investors -- Exotic and Invasive Freshwater Fishes in the Tigris-Euphrates River System -- Part IV. Water Resources -- The Ecology and Modelling of the Freshwater Ecosystems in Iran -- Enhancing Rural Women’s Participation in Fisheries in Iraq -- The Impact of Destructive Fishing Gear on the Fish Biodiversity in the Inland Waters of Iraq -- Evaluating Variations in Fisheries by Means of Fishers’ Information: Suggested Methodology to Improve Small-Scale Fisheries in Rivers in Iraq -- A Possibility to Apply a Traditional Fisheries Enforcement Programme in the Inland Waters of Iraq -- Market-Resource Relations and Fish Seller Livelihood as Seen in Inland Waters of Iraq -- The Potential Impact of Deformities in Fishes upon Aquatic Production: Case of Iraq -- The Impact of some Social Taboos on Fisheries in Iraq -- Inland Water Fishes and Fisheries in Iran -- The Possibility of Introducing an Inland Fisheries Education in Iraq -- The Marine and Diadromous Fisheries of Iraq -- Part V. Stress of the Environment of the Two Rivers -- Fish Deformities in the Freshwater Fishes of Iraq: A Short Review and a Study Case on the Indian Catfish Heteropneustes fossilis -- The Phenomenon of Fluctuating Asymmetry: As Fish Welfare Indicator Represented by Case Study from the Freshwater Fishes of Iraq -- The Studies on Sediments Pollution by Different Types of Metals in Turkey -- Macroplastic and Microplastic in the Freshwater Environment of Southern Iraq: Evidences Obtained from Freshwater Fish Species -- Heavy Metals in Freshwater Invertebrates of Iran: A Review on the Bioaccumulation and Effects -- Fish Parasites of Tigris and Euphrates River Systems -- The Parasites of Fishes of the Euphrates and Tigris Rivers: Iraq and Turkey -- Ornamental Fishes: A Looming Danger for Inland Fish Diversity of Iraq -- Part VI. The Health of the Human Community Inhabiting Freshwater Zones -- Aquatic Snails as a Vector of Diseases to the Human in Iran -- Death by Drowning in Rivers in Iraq -- The Dangerous Catfish Species in the Freshwater System of Iraq: First Time Reports on Cases of Envenomation -- Fish Species of the Order Cypriniformes as a Source of Ichthyootoxin and Ichthyogallotoxin in Iraq: Cases Reports -- First Reports on Cases of Hallucinatory Fish Poisoning (Ichthyoallyeinotoxism) and Scombrotoxic Fish Poisoning in Iraq -- Part. VII. Conservation -- Freshwater Management and Conservation in Iran: Past, Present, and Future -- The Need of Biodiversity Conservation Strategies in Iraq: The State of Protected Areas -- Benthic Macroinvertebrates of the Tigris and Euphrates Rivers in Turkey -- Freshwater Ecosystem Conservation in Iraq: Recommendations for Management -- Utilising Phenotypic Difference to Regulate Protection Value: A Scheme for Application of a Novel Approach to the Inland Water of Iraq -- Hatchery-Reared Fish Stocks Released into the Wild: A Conservation Problem as Seen in a Case Study from Iraq -- Part VIII. Social Perspectives -- Is the Glass Half Empty or Half Full? An Appraisal of the Four Decades of Turkey’s Southeastern Anatolia Project (GAP) -- Part IX. Food Security -- How Possible to Build Rice–Fish Farming in Iraq in order to Support Food Security Plan: Positive and the Negative Aspects -- The Importance of Non-commercial and Small-Sized Fish Species: A Proposal for an Additional Revenue to Iraq -- Sociocultural Aspects Influence Food Consumption Habits in Iraq: Management of Food Security -- A Preliminary Investigation of Determinants of Food Security in Rural Areas of Basrah Province, Iraq.
    Abstract: The system of the Tigris-Euphrates Rivers is one of the great river systems of southwestern Asia. It comprises the Tigris and Euphrates Rivers, which follow roughly parallel courses through the heart of the Middle East. The lower portion of the region that they run through is known as Mesopotamia, was one of the cradles of civilisation. There are several environmental factors that govern the nature of the two rivers and shape the landscape the two rivers running through. Geological events create rivers, climate monitor the water supply, the surrounding land influences the vegetation and the physical and chemical features of water. The Tigris-Euphrates system runs through the territory of four countries, Iraq, Iran, Turkey and Syria. Therefore, any scientific approach to the environment of these two rivers should include the natural history events in these countries. The book "Tigris and Euphrates Rivers: Their Environment from Headwaters to Mouth" will be divided into nine parts. These parts deal with the issues of the environment, the status of the flora and fauna, the abiotic aspects, ecology, hydrological regime of the two rivers, the biotic aspects, water resources, stress of the environment, conservation issues. Since the book of Julian Rzoska "Euphrates and Tigris Mesopotamian Ecology and Destiny" in 1980, no book or major reference has been published that includes between its cover the facts and information that the present book will present. Therefore, the importance of the present book falls in stating the present status of the environment of the two rivers and the comparison of their environment between now and that of 37 years ago as given by J. Rzoska (1980). The recent studies showed that there are a large number of natural and political events that happened within the last three decades in the area of the Tigris-Euphrates river system that for sure have done a great change to the environment of the two rivers and consequently changing the biological and non-biological resources of the two rivers. This book will be a reference book to both academic researchers and students across the Middle East in different disciplines of knowledge to use in their researches on Tigris-Euphrates river system. The scholars interested in this area will use this book as a guide to compare this freshwater system with other areas in Asia and the world. .
    Type of Medium: Online Resource
    Pages: XXIII, 1640 p. 387 illus., 317 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030575700
    Series Statement: Aquatic Ecology Series, 11
    DDC: 577.6
    Language: English
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    Keywords: Freshwater ecology. ; Marine ecology. ; Biotic communities. ; Population biology. ; Animal culture. ; Conservation biology. ; Ecology . ; Freshwater and Marine Ecology. ; Community and Population Ecology. ; Animal Science. ; Conservation Biology. ; Ecosystems.
    Description / Table of Contents: Introduction. The Lake Charr: Biology, Ecology, Distribution, and Management -- Distribution -- Paleoecology -- Ecological Diversity -- Genetic Diversity -- Habitat -- Movement Ecology and Behavior -- Life History and Population Dynamics -- Trophic Ecology -- Reproduction -- Contaminants and Ecotoxicology -- A General, Life History Based Model for Sustainable Exploitation of Lake Charr across their Range -- Terminology Issues in Lake Charr Early Development.
    Abstract: The lake charr Salvelinus namaycush is a ubiquitous member of cold-water lake ecosystems in previously glaciated regions of northern continental U.S., Alaska, and Canada that often support important commercial, recreational, and subsistence fisheries. The lake charr differs from other charrs by its large size, longevity, iteroparity, top-predator specialization, reduced sexual dimorphism, prevalence of lacustrine spawning, and use of deepwater habitat. The species is remarkably variable in phenotype, physiology, and life history, some of which is reflected in its ecology and genetics, with as many as four morphs or ecotypes co-occurring in a single lake. The lake charr is often the top predator in these systems, but is highly adaptable trophically, and is frequently planktivorous in small lakes. The lake charr by their name highlights their common habitat, lakes both large and small, but often frequents rivers and occasionally moves into the Arctic Ocean. Movement and behaviour of lake charr are motivated by access to cool, well-oxygenated water, foraging opportunities, predator avoidance, and reproduction. Owing to their broad distribution and trophic level, the lake charr serves as a sentinel of anthropogenic change. This volume will provide an up-to-date summary of what is currently known about lake charr from distribution to genetics to physiology to ecology. The book provides a compilation and synthesis of available information on the lake charr, beginning with an updated distribution and a revised treatment of the paleoecology of the species. Understanding of ecological and genetic diversity and movement and behaviour of the species has advanced remarkably since the last major synthesis on the species over 40 years ago. Mid-sections of the book provide detailed accounts of the biology and life history of the species, and later sections are devoted to threats to conservation and fishery management practices used to ensure sustainability. A new standard lake charr-specific terminology is also presented. The book will be a valuable reference text for biologists around the world, ecologists, and fishery managers, and of interest to the angling public.
    Type of Medium: Online Resource
    Pages: XXXVII, 497 p. 107 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030622596
    Series Statement: Fish & Fisheries Series, 39
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Dordrecht :Springer Netherlands :
    Keywords: Freshwater ecology. ; Marine ecology. ; Ecology . ; Evolution (Biology). ; Biodiversity. ; Freshwater and Marine Ecology. ; Evolutionary Ecology. ; Ecology. ; Biodiversity.
    Description / Table of Contents: Chance, Choice and Cichlids -- Frontiers in Cichlid Research: A History of Scientific Advancement -- Ecological Opportunity, Genetic Variation, and the Origins of African Cichlid Radiations -- Evolution in the Fast Lane: Diversity, Ecology, and Speciation of Cichlids in the lower Congo River -- Neotropical Riverine Cichlids: Adaptive Radiation and Macroevolution at Continental Scales -- Sympatric and Allopatric Diversification in the Adaptive Radiation of Midas Cichlids in Nicaraguan Lakes -- The Consequences of Anthropogenic Stressors on Cichlid Fish Communities: Revisiting Lakes Victoria, Kyoga, and Nabugabo -- Rapid Evolutionary Responses in Cichlids: Genetics of Adaptation, Morphology and Taxonomic Implications -- Identifying and Conserving Tilapiine Cichlid Species in the 21st Century -- Introduced Cichlids in the Americas: Distribution Patterns, Invasion Ecology, and Impacts -- The Evolutionary Ecology of Cichlid Vision -- The Mechanosensory Lateral Line System of Cichlid Fishes: From Anatomy to Behavior -- Sonic Cichlids -- The Evolution of Enhanced Cichlid Hearing: Functional Morphology and the Role of Ecoacoustical Factors -- Parental Care in Cichlid Fishes -- Cichlids as a model system for studying social behaviour and evolution -- Integrative Neurobiology of Social Behavior in Cichlid Fish -- Respiratory Ecology of Cichlids -- Feeding Ecology of Lake Tanganyika Cichlids -- Patterns of Trophic Evolution: Integration and Modularity of the Cichlid Skull -- An Evo-devo View of Post-genomic African Cichlid Biology: Enhanced Models for Evolution and Biomedicine.
    Abstract: This volume constitutes the most recent and most comprehensive consideration of the largest family of bony fishes, the Cichlidae. This book offers an integrated perspective of cichlid fishes ranging from conservation of threatened species to management of cichlids as invasive species themselves. Long-standing models of taxonomy and systematics are subjected to the most recent applications and interpretations of molecular evidence and multivariate analyses; and cichlid adaptive radiations at different scales are elucidated. The incredible diversity of endemic cichlid species in African lakes is revisited as possible examples of sympatric speciation and as serious cases for management in complex anthropogenic environments. Extreme hydrology and bathymetry as driver of micro-allopatric speciation is explored in the African riverine hotspot of diversity of the lower Congo River. Dramatic new molecular evidence draws attention to the complex taxonomy and systematics of Neotropical cichlids including the crater lakes of Central America. Molecular genetics, genomics, imaging tools and field study techniques assess the roles of natural, sexual and kin selection in shaping cichlid traits and beyond. The complex behavioral adaptations of cichlids are considered from a number of sub-disciplines including sensory biology, neurobiology, development, and evolutionary ecology. Most importantly, this volume puts forth a wealth of new interpretations, explanatory hypotheses and proposals for practical management and applications that will shape the future for these remarkable fishes in nature as well as their use as models for the study of biology.
    Type of Medium: Online Resource
    Pages: XVI, 828 p. 154 illus., 108 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789402420807
    Series Statement: Fish & Fisheries Series, 40
    DDC: 577.6
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cell death. ; Cancer Biology. ; Cell Death.
    Description / Table of Contents: Preface -- Introduction -- The intersection of anoikis resistance and fatty acid metabolism in cancer -- Anoikis resistance in melanoma -- Anoikis mediated by stress-activated MAPK signaling pathways -- Metabolic Regulation of Anoikis -- Metabolic Reprogramming contributes to Anoikis resistance in Cancer Cells -- Role of the nuclear receptors in anoikis -- The roles of anoikis in cervical cancer -- Shc and the control of small GTPase dynamics in cellular anchorage -- Anoikis and the Human Gut Epithelium in Health and Disease -- Epithelial cell extrusion: the prelude to anoikis -- Microtubule modifications and mitochondria: role in anoikis.
    Abstract: This book provides a useful resource for graduate-level cancer cell biology courses. Since the first report, in 1994, of “anoikis”—the apoptosis that occurs when cells lack appropriate contact with the extracellular matrix—over 2,100 papers have been published on this subject. This book is the first comprehensive, in-depth and up-to-date compendium on anoikis. Chapters are authored by some of the leading researchers in the field. This book provides both mechanistic and translational information regarding anoikis, in a convenient format. Mechanistically, the following topics will be addressed in detail: The role of MAP kinase signaling The role of Shc proteins as cellular anchorage sensors The role of cellular metabolism, and fatty acid metabolism in particular, and how they are affected by oncogenic transformation How epithelial cell extrusion – the prelude to anoikis—is regulated in normal and cancer cells The convergence of TGF-b and androgen receptor signaling in the regulation of anoikis This book also discusses the specialized functions and dysregulation of anoikis in the following cancer settings: Colon cancer Melanoma Cervical cancer The book serves to update i nvestigators actively working on problems in the anoikis field, in either experimental or translational settings. For investigators encountering novel biological phenomena that might relate to anoikis, it serve as an entry point to the literature that does not require an extensive background in cell adhesion signaling or apoptosis mechanisms. .
    Type of Medium: Online Resource
    Pages: VIII, 202 p. 6 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030738563
    DDC: 571.978
    Language: English
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  • 86
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Animal culture. ; Plants Evolution. ; Conservation biology. ; Ecology . ; Biodiversity. ; Freshwater and Marine Ecology. ; Animal Science. ; Plant Evolution. ; Conservation Biology. ; Biodiversity.
    Description / Table of Contents: Preface -- The Bahía Blanca Estuary in a regional context -- Geography of the Bahía Blanca Estuary -- Physical Oceanography of the Bahía Blanca Estuary -- Bahía Blanca Estuary: a chemical oceanographic approach -- Plankton ecology and biodiversity in the Bahía Blanca Estuary -- Biology and ecology of the benthic algae -- The intertidal meiobenthos of the Bahía Blanca Estuary -- The intertidal soft-bottom macrobenthic invertebrates -- Taxonomic and functional approach of subtidal macrobenthic communities in the Bahía Blanca Estuary (Argentina) -- Shrimps and prawns -- Ecology and biology of the fish assemblages -- The Bahia Blanca Estuary and importance of the wetlands for the conservation of see turtles -- Shorebirds and Seabirds’ Ecology and Conservation -- Marine mammals: is the Bahía Blanca Estuary and its area of influence important for their conservation? -- Use of coastal area habitats by land mammals -- Coastal wetlands of the Bahía Blanca Estuary. Landscape structure and plant associations -- Environmental diagnosis of the protected coastal areas of the Bahía Blanca Estuary -- Small-scale artisanal fishers and socio-environmental conflicts in estuarine and coastal wetlands -- Estuarine environmental monitoring programs: long term studies -- Environmental education: mud and salt classrooms -- Index.
    Abstract: The Bahía Blanca Estuary is one of the largest coastal systems in Atlantic South America. This mesotidal estuary, situated in a sharp transition between humid subtropical and semiarid climates, has a unique combination of large interannual climatic variations. The estuarine area encompasses roughly 2300 square kilometers and is composed of wide expanses of intertidal flats, salt marshes, and emerged islands, which create intricate landscape patterns. Natural environments in the estuary sustain a high concentration of marine and terrestrial species, including endemic, threatened, and endangered fish and shorebirds. Puerto Cuatreros, in the inner zone of the estuary, hosts a permanent marine research station, whose records span more than 30 years of biophysical variables, and represent one of the largest time series of ecological data in South America. Beyond its ecological relevance, the Bahía Blanca Estuary is under increasing anthropogenic pressure from large urban settlements, industrial developments and harbors, raising the question of how to balance conservation and development. The Bahía Blanca Estuary: Ecology and Biodiversity offers a comprehensive review of life in the ecosystems of the estuary. The book is divided into five major sections, the first of which provides a description of the regional setting and covers key aspects of estuarine dynamics. The three following sections are dedicated to different habitat types and, within each section, the chapters are organized around major functional groups from pelagic and benthic environments. The fifth and final section covers issues related to management and conservation. Overall, the book provides essential and up-to-date reference material on the biodiversity and ecosystem processes of the Bahía Blanca Estuary, and will appeal to a broad international audience.
    Type of Medium: Online Resource
    Pages: XIII, 581 p. 95 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030664862
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Cancer Biology. ; Medical Microbiology. ; Biomedical Research. ; Human Physiology. ; Immunology.
    Description / Table of Contents: Chapter 1: The Microbiome And The Hallmarks Of Cancer -- Chapter 2: Microbiome In Human GI Cancers -- Chapter 3: The Gut Microbiome And Colorectal Cancer -- Chapter 4: Salmonella Infection In Human Cancers -- Chapter 5: Biomarkers Of Esophageal Cancers And Precancerous Lesions -- Chapter 6: Epithelial And Immune Cell Responses To Helicobacter Pylori That Shape The Gastric Tumor Microenvironment -- Chapter 7: Microbiome And Liver Cancer -- Chapter 8: THE MICROBIOME AND UROLOGIC CANCERS -- Chapter 9: Role Of Infections And Tissue Inflammation In The Pathology Of The Fallopian Tube And High-Grade Serous Ovarian Cancer -- Chapter 10: Commensal Microbes And Their Metabolites: Influence On Host Pathways In Health And Disease -- Chapter 11: Dietary And Microbiome In Cancer Prevention -- Chapter 12: Autophagy And Cancer-Current Biology And Drug Development -- Chapter 13: Mitochondrial Regulation Of Inflammation In Cancer -- Chapter 14: Modern Germ-Free Study Designs And Emerging Static Housing Technology In A Growing ‘Human Microbiome’ Market -- Chapter 15: Machine Learning In Identification Of Disease-Associated Microbiota -- Chapter 16: Mediation Analysis Of Microbiome Data And Detection Of Causality In Microbiome Studies.
    Abstract: This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.
    Type of Medium: Online Resource
    Pages: XII, 509 p. 31 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030679514
    Series Statement: Physiology in Health and Disease,
    DDC: 571.978
    Language: English
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  • 88
    Keywords: Freshwater ecology. ; Marine ecology. ; Biotic communities. ; Plant ecology. ; Biodiversity. ; Freshwater and Marine Ecology. ; Ecosystems. ; Plant Ecology. ; Biodiversity.
    Description / Table of Contents: The Ecology of Plant Litter Decomposition in Stream Ecosystems: An Overview -- Multi-scale Biophysical Factors Driving Plant Litter Dynamics in Streams -- Stoichiometry of Plant Litter Decomposition in Stream Ecosystems -- Global Patterns of Plant Litter Decomposition in Streams -- Plant Litter Decomposition in Intermittent Rivers and Ephemeral Streams -- Plant Litter Decomposition in Terrestrial Ecosystems Compared to Streams -- Biodiversity and Plant Litter Decomposition in Streams -- The Role of Key Plant Species on Litter Decomposition in Streams: Alder as Experimental Model -- Linking Microbial Decomposer Diversity to Plant Litter Decomposition and Associated Processes in Streams -- The Role of Macro Invertebrates on Plant Litter Decomposition in Streams -- The role of Microscopically Small Invertebrates in Plant Litter Decomposition in Streams -- Individual and Interacting Effects of Elevated CO2, Warming, and Hydrologic Intensification on Plant Litter Decomposition in Streams -- Causes and Consequences of Changes in Riparian Vegetation for Plant Litter Decomposition Throughout River Networks -- Effects of Exotic Tree Plantations on Plant Litter Decomposition in Streams -- Salt Modulates Plant Litter Decomposition in Stream Ecosystems -- Pathways, Mechanisms and Consequences of Nutrient-stimulated Plant Litter Decomposition in Streams -- How Toxicants Influence Plant Litter Decomposition in Streams -- Effects of Engineered Nanoparticles on Plant Litter Decomposition in Streams -- The Construction of Plant Litter Decomposition Curves -- Design and Analysis of Laboratory Experiments on Aquatic Plant Litter Decomposition -- Plant Litter Decomposition as a Tool for Stream Ecosystem Assessment -- Plant Litter Decomposition as a Contributor to Stream Ecosystem Service Provision.
    Abstract: With almost 90% of terrestrial plant material entering the detrital pool, the processing of this significant carbon source is a critical ecosystem function to understand. Riverine ecosystems are estimated to receive, process and transport nearly 1.9 Pg of terrestrial carbon per year globally, highlighting the focus many freshwater ecologists have on the factors that explain decomposition rates of senesced plant material. Since Webster and Benfield offered the first comprehensive review of these factors in 1986, there has been an explosion of research addressing key questions about the ecological interactions at play. Ecologists have developed field and laboratory techniques, as well as created global scale collaborations to disentangle the many drivers involved in the decomposition process. This book encapsulates these 30+ years of research, describing the state of knowledge on the ecology of plant litter decomposition in stream ecosystems in 22 chapters written by internationally renowned experts on the subject.
    Type of Medium: Online Resource
    Pages: IX, 523 p. 68 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030728540
    DDC: 577.6
    Language: English
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  • 89
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Ecology . ; Oceanography. ; Ecological genetics. ; Freshwater and Marine Ecology. ; Biodiversity. ; Biooceanography. ; Ecological Genetics.
    Description / Table of Contents: 1 Aquaculture Productivity Enhancement through Advanced Technologies -- 2 Indigenous fishes as valued genetic resources -- 3 Applications of Next Generation Sequencing in Aquaculture and Fisheries -- 4 Genome Sequencing in Fishes -- 5 Omics in Aquaculture -- 6 Gowth Hormone Transgenesis in Aquaculture -- 7 Genome Editing in Fish Reproduction -- 8 Metabolomics: a Novel Technology for Health Management in Aquaculture -- 9 Epigenetics: Perspectives and Potential in Aquaculture -- 10 Application of Stem Cell Based Technologies in Management of Fisheries Resources -- 11 Molecular Markers in Fisheries and Aquaculture -- 12 Microsatellite Markers for Fish Conservation -- 13 Cryopreservation in Aquaculture -- 14 Nanobiotechnology: Prospects and Applications in Aquaculture -- 15 Application of Nanotechnology for Abiotic Stress Management in Aquaculture -- 16 Nutritional biotechnology to augment aquaculture production -- 17 Colour enhancement in ornamental fishes -- 18 Immunoprophylactic Measures in Aquaculture -- 19 DNA Vaccines for Fish -- 20 Bacteriophage Therapy in Aquaculture: An Overview -- 21 Disease Diagnostic Tools for Health Management in Aquaculture -- 22 Prospect and Challenges of Biofloc Technology for Sustainable Aquaculture Development -- 23 Biofilm in Aquaculture Production -- 24 Bioremediation of Aquatic Environment -- 25 Effects of Pharmaceutical Waste in Aquatic Life -- 26 Biosafety and Biosecurity for Sustainable Aquaculture Development -- 27 Specific Pathogen Free (SPF) Shrimps in Aquaculture -- 28 Enzymes from Aquatic Resources and their Application in Food and Cosmetic Industry -- 29 Biotechnological approaches to valorization of aquaculture bio-wastes and their biomedical applications. .
    Abstract: The book covers various biotechnological research efforts and their applications in fisheries and aquaculture, especially in the area of fish breeding, health management, nutrition and culture. Application of the recent biotechnological tools, like Transcriptomics, Transgenesis, Nanotechnology, Metabolomics, RNAi and CRISPRi Technologies in the field of fisheries research are included in the book. Topics like conservation genetics for management of fishery resources are also covered in the book. It aims at addressing the growing need of the biotechnology in advancing the cause of aquaculture with a view to provide food and nutritional security to the world. This book will be of immense use to teachers, researchers, academicians, development officials and policymakers, involved in R&D of fisheries and aquaculture sectors. Also, the book serves as an additional reading material for undergraduate and graduate students of fisheries, marine sciences, ecology, aquaculture, and environmental sciences. The research in aquaculture biotechnology is likely to have significant impact on aquaculture and fisheries by way of supporting nutritional food security to the growing population.
    Type of Medium: Online Resource
    Pages: XVI, 521 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811632150
    DDC: 577.6
    Language: English
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  • 90
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Molecular genetics. ; Proteins . ; Cancer Biology. ; Molecular Genetics. ; Protein Biochemistry.
    Description / Table of Contents: Chapter 1: Overview of histone modification -- Chapter 2: The histone H3 family and its deposition pathways -- Chapter 3: Histone H3K27M Mutation in Brain Tumors -- Chapter 4: Histone Mutations and Bone Cancers -- Chapter 5: Histone H3G34 mutation in brain and bone tumors -- Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target.
    Abstract: This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.
    Type of Medium: Online Resource
    Pages: VII, 96 p. 17 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811581045
    Series Statement: Advances in Experimental Medicine and Biology, 1283
    DDC: 571.978
    Language: English
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  • 91
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Human physiology. ; Diseases. ; Oncology. ; Regenerative medicine. ; Cancer Biology. ; Human Physiology. ; Diseases. ; Oncology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Chapter 1. Isolation and characterization of extracellular vesicles: classical and modern approaches -- Chapter 2. Characterization and fine structure of exosomes -- Chapter 3. Extracellular vesicles mediate the embryonic-maternal paracrine communication -- Chapter 4. The interplay between oviduct-derived exosomes and cumulus-oocyte complexes -- Chapter 5. The interplay between exosomes and spermatozoa -- Chapter 6. Mesenchymal stem cell-derived exosomes and regenerative medicine -- Chapter 7. Therapeutic Potential of Mesenchymal Stem/Stromal Cell Derived-Exosomes -- Chapter 8. Exosomes in Neurodegenerative Disorders -- Chapter 9. Differential expression of exosomal microRNAs in neurodegenerative diseases -- Chapter 10. Urinary exosomes as a possible source of kidney disease biomarkers -- Chapter 11. Extracellular vesicles as potential therapeutic targets and biomarkers for liver disease -- Chapter 12. Implications of extracellular vesicles in blood protozoan parasitic diseases -- Chapter 13. Cancer cells-derived Exosomes and Metastasis -- Chapter 14. Extracellular vesicles and integrins: partners in cancer progression -- Chapter 15. Exosomes: the crucial element in the prostate cancer -- Chapter 16. Exosomal microRNAs: Potential Biomarkers for Cancer Diagnosis, Treatment Response, and Prognosis -- Chapter 17. Exosomes in drug delivery -- Chapter 18. Exosomes and Supported Lipid Layers as Advanced Naturally Derived Drug Delivery Systems.
    Abstract: This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.
    Type of Medium: Online Resource
    Pages: XII, 373 p. 34 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811565991
    DDC: 571.978
    Language: English
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  • 92
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. NMR-Based Metabolomics in Cancer Research -- 2. Capillary Electrophoresis–Mass Spectrometry for Cancer Metabolomics -- 3. Chemical Isotope Labeling LC-MS for Metabolomics -- 4. Single cell metabolomics by mass spectrometry imaging -- 5. Fatty Acid Metabolism and Cancer -- 6. Metabolomics of Gastric Cancer -- 7. HIF-1α metabolic pathways in human cancer -- 8. Regulation of glycolysis in head and neck cancer -- 9. Metabolomics of oral/head and neck cancer -- 10. Ion chromatography with mass spectrometry for metabolomic analysis -- 11. Methods of lipidomic analysis: Extraction, derivatization, separation and identification of lipids -- 12. Functional metabolomics and chemoproteomics approaches reveal novel metabolic targets for anti-cancer therapy -- 13. Metabolomics of glioma -- 14. Microbial metabolomics: From methods to translational applications -- 15. Advances in the study of N6-methyladenine in eukaryotes -- 16. NMR Based Metabolomics -- 17. Quantitative analysis of oncometabolite 2-hydroxyglutarate -- 18. Tracer-based Cancer Metabolomic Analysis -- 19. Mass spectrometry-based shotgun lipidomics for cancer research -- 20. Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry-based Metabolomics.
    Abstract: Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
    Type of Medium: Online Resource
    Pages: XV, 312 p. 80 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030516529
    Series Statement: Advances in Experimental Medicine and Biology, 1280
    DDC: 571.978
    Language: English
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  • 93
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Immunology. ; Cancer Biology. ; Immunology.
    Description / Table of Contents: 1. The role of targeted therapy in multiple myeloma -- 2. Lenalidomide -- 3. Pomalidomide -- 4. Mechanisms driving resistance to proteasome inhibitors bortezomib, carfilzomib and ixazomib in multiple myeloma -- 5. Daratumumab -- 6. Elotuzumab -- 7. Histone deacetylase inhibitors -- 8. Bone targeted therapies -- 9. New targeted therapies for multiple myeloma under clinical investigation.
    Abstract: Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.
    Type of Medium: Online Resource
    Pages: XVII, 154 p. 5 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030734404
    Series Statement: Resistance to Targeted Anti-Cancer Therapeutics, 22
    DDC: 571.978
    Language: English
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  • 94
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Notch signaling in prevention ant therapy: fighting cancer with a two-sided sword -- Transcription factor RBPJ as a molecular switch in regulating the Notch response -- Unraveling of Hidden Secrets: The tumour suppressor Lethal (2) giant discs (Lgd)/CC2D1, Notch Signaling and Cancer -- Notch and endometrial cancer -- Notch and Esophageal Squamous Cell Carcinoma -- Notch signaling and liver cancer -- Notch inHead and Neck Cancer -- Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis -- The impact of Notch signalingfor carcinogenesis and progression of non-melanoma skin cancer: lessons learned fromcancer stem cells, tumor angiogenesis, and beyond -- Notch Signaling in Thyroid Cancer -- The Relevance of Notch Signaling in Cancer Progression -- Notch Signaling and the Breast Cancer Microenvironment -- Notch pathway: a journey from notching phenotypes to cancer immunotherapy -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books -- Notch Signaling and Embryologic Development and Molecular Basis of Notch Signaling – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XVII, 228 p. 28 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030550318
    Series Statement: Advances in Experimental Medicine and Biology, 1287
    DDC: 571.978
    Language: English
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  • 95
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Microtechnology. ; Microelectromechanical systems. ; Cancer Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Microsystems and MEMS.
    Description / Table of Contents: Chapter 1. Strategies to improve oral delivery of natural anticancer molecules -- Chapter 2. Nanoparticles catalyzing enzymatic reactions: recent developments and future prospects -- Chapter 3. Biogenic silver nanoparticles: A potent therapeutic agent -- Chapter 4. Translational studies of nanofibers-based scaffold for skin and bone tissue regeneration -- Chapter 5. Functional Dendritic Coatings for Biomedical Implants -- Chapter 6. Application of nanotherapeutics for combating human protozoan parasitic infections.
    Abstract: This book illustrates the significance of nanotechnology in the delivery of anticancer and antimicrobial drugs, biomimetic technologies, tissue engineering, sensing, diagnostics, and artificial enzymes. It first briefly discusses the use of nanotechnology for the delivery of anticancer medications, and the concept and applications of catalytically active nanomaterial-based artificial enzymes for sensing and diagnostic applications. It then explores the use of silver nanoparticle-based novel antimicrobials, and comprehensively reviews the role of nanomaterials in developing biomedical implants and tissue engineering applications. Lastly, it offers a detailed description of nanotherapeutics for combating human protozoan parasitic infections. Cutting across the disciplines, this book serves as a guide for researchers and scientists in biotechnology, medical science and material science.
    Type of Medium: Online Resource
    Pages: XIV, 240 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811599200
    DDC: 571.978
    Language: English
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  • 96
    Keywords: Cancer. ; Tumor markers. ; Medical screening. ; Materials. ; Detectors. ; Cancer Biology. ; Tumour Biomarkers. ; Cancer Screening. ; Sensors and biosensors.
    Description / Table of Contents: Chapter 1. An Introduction to Cancer Biomarkers -- Chapter 2. Cervical Cancer -- Chapter 3. Potential Biomarkers for Early Diagnosis of Cervical Cancer -- Chapter 4. Methods for Screening of Cervical Cancer: State of Art -- Chapter 5. Electrochemical DNA Biosensors for Cervical Cancers -- Chapter 6. Optical DNA based Sensors for Cervical Cancers -- Chapter 7. Other Biosensors for Cervical Cancer Detection.
    Abstract: This book highlights both conventional and nanomaterials-based biosensors for the detection of cervical cancers. It describes developments in the selective and sensitive electrochemical biosensors based on DNA for the early diagnosis of cervical cancer. Further, this book covers other nano-biosensing systems such as nano-thermometry-based sensing platforms, mechanical sensing platforms encompassing piezoelectric-based sensors, electrochemical impedance spectroscopy based on PEGylated arginine functionalized magnetic nanoparticles, and field-effect transistor-based platforms for the early detection of cervical cancer. Also, it presents conventional platforms such as vibrational spectroscopy and polymerase chain reaction techniques for the diagnosis of cervical cancer. Finally, it reviews currently available biomarkers for the early diagnosis of cervical cancer and presents strategies for developing novel biomarkers based on cellular and molecular approaches. As such, this book is a comprehensive resource for researchers and clinicians working in cervical cancer diagnostics.
    Type of Medium: Online Resource
    Pages: IX, 115 p. 18 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811625862
    DDC: 571.978
    Language: English
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  • 97
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Cancer Microenvironment. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: 1. The Tumour Microenvironment and Circulating Tumour Cells: A partnership driving metastasis and glycan-based opportunities for cancer control -- 2. Dormancy in the Tumor Microenvironment -- 3. Tumor-associated tertiary lymphoid structures: A cancer biomarker and a target for next-generation immunotherapy -- 4. Studying the tumor microenvironment in zebrafish -- 5. Pre-metastatic niche formation by neutrophils in different organs -- 6. Tumor cell invasion and the tumor microenvironment: Special focus on brain tumors -- 7. The dog as a model to study the tumor microenvironment -- 8. EFFEROCYTOSIS AND THE STORY OF “FIND ME’’, ‘’EAT ME” AND “DON’T EAT ME” SIGNALING IN THE TUMOR MICRO ENVIRONMENT -- 9. Color-coded imaging of the tumor micro-environment (TME) in human patient-derived orthotopic xenograft (PDOX) mouse models -- 10. Mitochondria and the tumor microenvironment in blood cancer -- 11. Telocytes in the tumor microenvironment -- 12. Modeling the roles of astrocytes in the metastatic tumor cell microenvironment -- 13. Roles of fibroblasts in microenvironment formation associated with radiation-induced cancer -- 14. Tumor microenvironment-associated pericyte populations may impact therapeutic response in thyroid cancer -- 15. The adrenergic nerve network in cancer -- 16. Current treatment modalities targeting tumor microenvironment in castration-resistant prostate cancer -- 17.Brain metastases and tumor microenvironment -- 18. MIGRATION STIMULATING FACTOR (MSF). ITS ROLE IN THE TUMOUR -- MICROENVIRONMENT -- 19. Mechanical Signaling in the Mammary Microenvironment - from Homeostasis to Cancer -- 20. Osteopontin Signaling in Shaping Tumor Microenvironment Conducive to Malignant Progression -- 21. Progesterone receptor signaling in the breast tumor microenvironment -- 22. Progranulin/GP88, a complex and multi-faceted player of tumor growth by direct action and via the tumor microenvironmen -- 23. Sex-based differences in the tumor microenvironmet. .
    Abstract: This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 548 p. 79 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030731199
    Series Statement: Advances in Experimental Medicine and Biology, 1329
    DDC: 571.978
    Language: English
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  • 98
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Proteins . ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Protein Biochemistry. ; Internal Medicine.
    Description / Table of Contents: CCL2 in the tumor microenvironment -- CXCL3 signaling in the tumor microenvironment -- CXCL8 Signaling in the Tumor Microenvironment -- CXCL11 signaling in the tumor microenvironment -- CXCL12 signaling in the tumor microenvironment -- CXCL13 signaling in the tumor microenvironment -- CCL24 signaling in the tumor microenvironment -- CCL25 signaling in the tumor microenvironment -- CCL27 signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression, their regulation, and their roles in immune cell recruitment, as well as how they affect cancer immunity and tumorigenesis. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Chemokines – Part Bupdates us on what we know about various aspects of the tumor microenvironment, as well as apprises us on future directions in the field. This book is essential reading for advanced cell biology and cancer biology students as well as scientists seeking an update on recent developments and research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: IX, 139 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030626587
    Series Statement: Advances in Experimental Medicine and Biology, 1302
    DDC: 571.978
    Language: English
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  • 99
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. Defining breast cancer -- 2: Breast Cancer Recurrence and Survival -- 3: Synopsis of the Treatment of Breast Cancer -- 4: The Present Treatment of Hereditary Breast Cancer -- 5: Basis for the Epigenetic Treatment of Triple Negative Breast Cancer -- 6: A New Treatment Strategy foe BRCA1 Related Breast Cancer -- 7: Present Options in the Prevention of Breast Cancer -- 8: The Physiological Basis of Breast Cancer Prevention -- 9: The Present and Future of Screening in Breast Cancer Prevention -- 10: A Vision of the Future.
    Abstract: The objective of this book is to provide a critical analysis of the present prevention strategies for breast cancer, emphasizing the cost benefits and quality of life of the patient. Rooted in the present knowledge of breast cancer biology and prevention and treatment options, the book will describe the future tools that could be available to oncologists and how these new approaches may change the landscape of recurrence and survival of the disease. Special emphasis will be given to the prevention strategies counterposing the present limitations and conflicting prevention guidelines for both hereditary and preventive non-hereditary breast cancer, and propose how the implementation of new strategies based on the present knowledge could save millions of lives and be more cost efficient. The book will present a critical status of the treatment and prevention of breast cancer and detail how a quantum leap could be achieved in the field by applying present basic research knowledge to clinical application.
    Type of Medium: Online Resource
    Pages: XI, 192 p. 41 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030728151
    DDC: 571.978
    Language: English
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  • 100
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Biotic communities. ; Biodiversity. ; Freshwater and Marine Ecology. ; Ecosystems. ; Biodiversity.
    Description / Table of Contents: Dedication -- Preface to the Third Edition -- Acknowledgements -- Preface to the Second Edition -- 1. Rivers in the Anthropocene -- 2. Streamflow -- 3. Fluvial Geomorphology -- 4. Stream Chemistry -- 5. The Abiotic Environment -- 6. Primary Producers -- 7. Detrital Energy and the Decompposition of Organic Matter -- 8. Stream Microbial Ecology -- 9. Trophic Relationships -- 10. Species Interactions -- 11. Lotic Communities -- 12.Energy Flow and Nutrient Cycling in Aquatic Communities -- 13. Nutrient Dynamics -- 14. Carbon Dynamics and Stream Ecosystem Metabolism -- 15. How We Manage Rivers, And Why. .
    Abstract: Stream Ecology: Structure and Function of Running Waters is designed to serve as a textbook for advanced undergraduate and graduate students, and as a reference source for specialists in stream ecology and related fields. This Third Edition is thoroughly updated and expanded to incorporate significant advances in our understanding of environmental factors, biological interactions, and ecosystem processes, and how these vary with hydrological, geomorphological, and landscape setting. The broad diversity of running waters – from torrential mountain brooks, to large, lowland rivers, to great river systems whose basins occupy sub-continents – makes river ecosystems appear overwhelming complex. A central theme of this book is that although the settings are often unique, the processes at work in running waters are general and increasingly well understood. Even as our scientific understanding of stream ecosystems rapidly advances, the pressures arising from diverse human activities continue to threaten the health of rivers worldwide. This book presents vital new findings concerning human impacts, and the advances in pollution control, flow management, restoration, and conservation planning that point to practical solutions. Reviews of the first edition: ".. an unusually lucid and judicious reassessment of the state of stream ecology" Science Magazine "..provides an excellent introduction to the area for advanced undergraduates and graduate students…" Limnology & Oceanography "… a valuable reference for all those interested in the ecology of running waters." .
    Type of Medium: Online Resource
    Pages: XVII, 485 p. 281 illus., 42 illus. in color. , online resource.
    Edition: 3rd ed. 2021.
    ISBN: 9783030612863
    DDC: 577.6
    Language: English
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