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  • Books  (2,747)
  • thema EDItEUR::N History and Archaeology  (1,535)
  • bic Book Industry Communication::M Medicine  (1,212)
  • 2020-2024  (2,747)
  • 1950-1954
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  • Books  (2,747)
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  • 1
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    John Miles Foley's World of Oralities (2021)
    Arc Humanities Press
    Details
    Publication Date: 2024-03-27
    Description: This collection brings together newly commissioned and cutting-edge essays on oral text and tradition ranging from the ancient and medieval world to the present day by a leading group of European and North American oral theorists. Using a range of materials including the Bible, Greek epic, Beowulf, Old Norse and Old English riddles, and medieval music, the contributors collectively work to refine, challenge, and further advance contemporary Oral Theory, an interdisciplinary school of thought heavily influenced by John Miles Foley, whose work provides the jumping-off point for this volume. The book includes a useful introduction to the history of oral theory and Foley’s ground-breaking and influential work.
    Keywords: Oral tradition; orality; performance; composition; narrative; Old Norse; Folklore; Beowulf; Medieval Music; Scandinavian religion; Anglo-Saxon Literature ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBB Literary studies: ancient, classical and medieval ; thema EDItEUR::D Biography, Literature and Literary studies::DB Ancient, classical and medieval texts ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRR Other religions and spiritual beliefs::QRRT Indigenous, ethnic and folk religions and spiritual beliefs::QRRT1 Indigenous religions, spiritual beliefs and mythologies of the Americas ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTD Oral history ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFF Historical and comparative linguistics ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500 ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history
    Language: English
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  • 2
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    Inszenierte Moderne. Populäres Theater in Berlin und London, 1880-1930 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Description: Modern popular culture came to the world from the stage. Even before film and radio had established themselves, popular theater had developed into a commercial and boundary-crossing entertainment industry that reached a mass audience. Tobias Becker compares the theater landscapes of London and Berlin and points out the cultural exchanges that took place between these metropolises during the long turn of the century (1880&#82111930).
    Keywords: D204-475 ; media history ; German-British history ; theater history ; urban history ; history of popular culture ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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  • 3
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    Provinz zwischen Reich und Republik. Politische Mentalitäten in Deutschland und Frankreich 1918-1933/36 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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  • 4
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    Normatividades e instituciones eclesiásticas en el virreinato del Perú, siglos XVI–XIX (2021)
    Max Planck Institute for Legal History and Legal Theory
    Details
    Publication Date: 2024-03-23
    Description: Ecclesiastical institutions and actors were essential for the formation of normative orders in early modern Ibero-America. In a series of seminars, organised by the Max Planck Institute for European Legal History in Mexico City, Lima, Bogotá and São Paulo, scholars from different disciplines presented innovative studies on the history of religious normativity and its practices. Based upon the Lima colloquium, the present volume focuses on the viceroyalty of Peru (16th-19th centuries).
    Keywords: Ibero-American history (16th–19th centuries) ; viceroyalty of Peru ; derecho indiano ; canon law ; church history ; ecclesiastical legislation ; litigation in canon law ; religious orders ; diocesan administration ; royal patronage ; evangelization ; thema EDItEUR::1 Place qualifiers::1K The Americas::1KL Latin America – Mexico, Central America, South America::1KLS South America::1KLSR Peru ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAZ Legal history
    Language: Spanish
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  • 5
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    Electrospun and Electrosprayed Formulations for Drug Delivery (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 6
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    Beverage Consumption Habits around the World: Association with Total Water and Energy Intakes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
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    La rencontre pacifique de deux mondes chrétiens (2023)
    École française d’Athènes
    Details
    Publication Date: 2024-03-23
    Description: In publishing this book, an early version of which was first published under the auspices of the Academy of Athens, the French School at Athens highlights the research work of Aspasia Louvi-Kizi, an eminent specialist in the Frank and Byzantine Peloponnese, whose work reveals all of the complexity of the architectural forms, influences and models at work in the monuments of the medieval Byzantine city of Mystras. Out of all of the architecture created by the despotic couple formed by Manuel Cantacuzène (1349-1380) and his wife Isabelle de Lusignan, who were instrumental in turning Mystras into a centre of power, Aspasia Louvi-Kizi focuses on two of the city’s most iconic monuments, the monasteries of Peribleptos and Pantanassa, proposing a new history of their construction. Their architecture incorporates elements of Frank art, meaning western or gothic art, which were foreign to the local Byzantine tradition. The gothic aspect of Mystras’ architecture, as distinct from the Franco-Byzantine influences in the neighbouring crusader principality of Achaea, has more to do with Western art in Cyprus, and its introduction by Isabelle to the Peloponnese was to prove decisive. The Western elements that decorate the facades of clocks and towers, combined with the Byzantine features to constitute a concrete expression of the despotic couple’s pro-Western politics, in line with the imperial politics of Constantinople at the time. In the fragmented and multipolar world of the Eastern Mediterranean on the eve of the Ottoman conquest, this book highlights the role Mystras played as a centre of power in the region and, in doing so, contributes to a fresh take on the city as a whole. By continuing the international conversation about a renowned site, the French School at Athens shows its commitment to a multi-layered approach that reveals the complexity of the interactions at work in the history of the Greek world in transition.
    Keywords: Byzantine art ; Byzantine Empire ; crusade ; Gothic art ; Lusignan ; Christian art ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGA History of art ; thema EDItEUR::6 Style qualifiers::6M Styles (M)::6MB Medieval style ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: French
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  • 8
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    Neuroimmune Interface in Health and Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 9
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    Sprachen der Wachsamkeit (2023)
    De Gruyter | De Gruyter
    Details
    Publication Date: 2024-03-24
    Description: This volume examines the linguistic dimension of vigilance in different contexts. The focus is on the social potentials, normative and regulative effects of languages as well as their use for marking dangers and orienting attention. This shows that language can be both an object and an instrument of vigilance and can itself become a medium of reflection of vigilance.
    Keywords: vigilance ; monitoring ; mindfulness ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTC Communication studies ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTD Semiotics / semiology ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: English , German
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  • 10
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    Der lateinische ›Alexanderroman‹ des Iulius Valerius (2023)
    De Gruyter | De Gruyter
    Details
    Publication Date: 2024-03-27
    Description: Within the scope of the Greek-Latin Alexander romance, the Res gestae Alexandri Macedonis by Julius Valerius (early fourth century CE) stand out due to their high literary and stylistic standards. The eleven contributions in this edited volume primarily focus on issues of narrative technique, linguistic design, and intertextuality, thereby illustrating the unique features and rank of this often-neglected work in literary history.
    Keywords: Alexander the Great ; Iulius Valerius ; Middle Latin ; Late Antiquity ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBB Literary studies: ancient, classical and medieval ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: German , English
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  • 11
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    Japan at War and Peace (2021)
    ANU Press | ANU Press
    Details
    Publication Date: 2024-04-02
    Description: The question of how to maintain the continuity of diplomacy while developing democracy without military intervention is an old and new issue. The challenge can be described as a dilemma between democracy and diplomatic coherence. This dilemma is not unique to the twenty-first century; it has been a constant challenge to the development of democracy. In non-Western countries, democratisation originated in the nineteenth century and has had many successes and failures. After the Russo-Japanese War, political parties began to take power in Japan. The best embodiment of diplomacy in Japan's emerging democracy—the development of parliamentary democracy and mass-based democracy—is Shidehara Kijūrō (1872–1951), who served as foreign minister from 1924 to 1927 and from 1929 to 1931, and was prime minister from 1945 to 1946. As a diplomat from the Ministry of Foreign Affairs, Shidehara had long grappled with the issue of how to ensure diplomatic coherence in modern Japan, which was becoming increasingly democratic. Although Shidehara succeeded to some extent in promoting diplomacy in cooperation with the US and the UK under party politics, the rise of the military after the Manchurian Incident forced him to retire for a period. However, after the Pacific War, Shidehara became prime minister of the US-occupied Japan and attempted to restore cooperative diplomacy under party politics. Shidehara came to the conclusion that the way to achieve both democracy and diplomatic coherence was through nonpartisan diplomacy towards peace. This book examines the tension between diplomacy and democracy, focusing on Shidehara’s life and exploring modern Japan’s footsteps. Shidehara was undoubtedly one of Japan’s most important diplomatic figures.
    Keywords: constitution ; War ; diplomacy ; Prime Minister ; Japan ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPQ Later 20th century c 1950 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations::JPSD Diplomacy
    Language: English
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  • 12
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    Contro frate Bernardino da Siena. Processi al maestro Amedeo Landi (Milano 1437-1447) (2021)
    Milano University Press
    Details
    Publication Date: 2024-04-01
    Description: The volume Contro Bernardino. Processi al maestro Amedeo Landi is the result of the discovery of unpublished documentation on the trials - only partly known - against the abacus master Amedeo Landi, who taught the Milanese merchants at the Broletto. This is an exceptional case not only because only one witness to the activity of the Milanese inquisitorial court in the Middle Ages (whose documentation has been entirely lost) was known until now, but also because of the role of the ecclesiastical court and its officials. The wealth of information and themes has prompted a team effort by the professors of the Department of Historical Studies to clarify the many aspects (political, religious, economic, documentary) of an event that shows the vitality of 15th-century Milan, in which the protagonist, the teacher Amedeo Landi, in an attempt to protect his students, clashes with the most important preacher of his time, Brother Bernardino of Siena, whose canonisation process is temporarily blocked precisely to shed light on the Milanese episode.
    Description: Published
    Description: Il volume Contro Bernardino. Processi al maestro Amedeo Landi nasce dal ritrovamento di documentazione inedita riguardo ai processi – solo in parte noti – contro il maestro d’abaco Amedeo Landi che insegnava ai mercanti milanesi presso il Broletto. Si tratta di un caso eccezionale non solo perché finora si conosceva un solo testimone dell’attività del tribunale inquisitoriale milanese nel medioevo (la cui documentazione è andata interamente perduta), ma anche per il ruolo del tribunale ecclesiastico e dei suoi funzionari. La ricchezza delle informazioni e dei temi ha suggerito un lavoro d’équipe dei docenti del Dipartimento di studi storici per chiarire i molteplici aspetti (politici, religiosi, economici, documentari) di una vicenda che mostra la vitalità della Milano quattrocentesca, in cui il protagonista, il maestro Amedeo Landi, nel tentativo di tutelare i suoi studenti si scontra con il più importante predicatore del suo tempo, frate Bernardino da Siena, il cui processo di canonizzazione viene momentaneamente bloccato proprio per fare luce sull’episodio milanese.
    Keywords: eresia ; mercanti ; Bernardino da Siena ; Amedeo Landi ; Milano medievale ; inquisizione ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: Italian
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  • 13
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    Recursos Críticos: história da cooperação técnica Opas-Brasil em recursos humanos para a saúde (1975-1988) (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Um livro valioso, que analisa com clareza o papel fundamental dos recursos humanos para a saúde e o desenvolvimento, bem como o contexto e o impacto da reforma sanitária e a relação entre as iniciativas internacionais, nacionais e locais em prol da mudança dos serviços de saúde. Além de examinar os antecedentes e os principais atores da área de recursos humanos e explicar com detalhes as negociações que visavam transformar em prioridade nacional a formação de recursos humanos e a distribuição dos trabalhadores de saúde no território, Recursos Críticos está apoiado em uma sólida pesquisa bibliográfica, testemunhos fascinantes e análise original, que fazem da obra uma contribuição significativa no campo da memória da saúde pública e uma ferramenta indicativa de perspectivas de futuro para trabalhadores na área da saúde. É uma pesquisa histórica de grande qualidade, voltada para a análise da cooperação Opas-Brasil, e um incentivo à realização de novos estudos sobre as interfaces entre a atuação de agências internacionais e os interesses nacionais, partindo do conceito de arenas ou espaços de negociação.
    Keywords: R5-920 ; Brasil ; Recursos humanos em saúde ; Planos e programas de saúde ; Cooperação técnica ; Organização Pan-Americana da Saúde ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 14
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    La stampa a Perugia nel Rinascimento (2022)
    FrancoAngeli
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    Publication Date: 2024-04-01
    Description: The art of printing with movable type made its appearance in Perugia -then as now, the heart of Italy- in 1471, when the city was under the sway of Braccio Baglioni. Perugia was home to an important university which had been attracting students from all over Europe for more than a century. They found hospitality in two colleges, of which the ‘Sapienza Vecchia’, in particular, was accustomed to accommodating students from abroad. The colleges were themselves instrumental in assisting the work of the earliest printers, all of them foreigners; their enterprise flourished for about fifteen years before strong competition from larger printing centres, notably Venice, took control of the Perugian book market. A second phase in local book production started at the turn of the century under the aegis of two major players, the Cartolari family and Bianchino dal Leone. The history of the book in Perugia is characterized by a quality and originality which is not reflected in the modest quantities produced there, and the major bibliographers have always taken an interest in it. All that and more can be found in this book, the outcome of lengthy research based on detailed analysis of all known editions and archival documents, including a number of new discoveries.
    Keywords: Early Printed Books ; Incunabula ; History of University ; Renaissance ; Perugia ; History of the Book ; Printing Press ; Braccio Baglioni ; Book Illustration ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::W Lifestyle, Hobbies and Leisure::WQ Local and family history, nostalgia::WQH Local history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics
    Language: Italian
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  • 15
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    Inhibiting PARP as a Strategic Target in Cancer (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 16
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    International Perspectives on Health and Safety Among Dairy Workers Challenges, Solutions and the Future (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 17
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    From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders；celiac disease；gluten intolerance ; bic Book Industry Communication::M Medicine
    Language: English
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  • 18
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    Akten zur Auswärtigen Politik der Bundesrepublik Deutschland 1977 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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  • 19
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    Microglia in Health and Disease: A Unique Immune Cell Population (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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    HLA-G-mediated Immune Tolerance: Past and New Outlooks (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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    The Jesuit Order as a Synagogue of Jews  (2021)
    Brill | Brill
    Details
    Publication Date: 2024-04-01
    Description: In The Jesuit Order as a Synagogue of Jews the author explains how Christians with Jewish ancestry went within less than forty years from having a leading role in the foundation and development of the Society of Jesus to being prohibited from membership in it. Readership: All those interested in converso and Jesuit history, the history of Catholicism, the history of late medieval and early modern Iberia and Italy, as well as Spanish literature historians, historians of law, and theologians.
    Keywords: History ; Jewish History & Culture ; Converso ; Ignatius of Loyola ; Rome ; Society of Jesus ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    European Monarchies from 1814 to 1906. A Century of Restorations (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Description: The year 2014 saw the 200th anniversary of Napoleon's downfall - and the restauration of the French monarchy under the house of Bourbon. With this as a starting point, Volker Sellin shows how the European monarchies restored and prolonged their reigns by giving their countries constitutions. This new angle results in an astonishing history of the 19th century in Europe from Spain to Russia.
    Keywords: D204-475 ; political legitimacy ; legal history ; constitutions ; Restauration ; monarchies ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    Les statuts communaux vus de l’extérieur dans les sociétés méditerranéennes de l’Occident (XIIe-XVe siècle) (2022)
    Éditions de la Sorbonne
    Details
    Publication Date: 2024-04-01
    Description: Ce volume est le quatrième d’une série d’ouvrages portant sur « Statuts, écritures et pratiques sociales dans les sociétés de la Méditerranée occidentale à la fin du Moyen Âge (XIIe-XVe siècle) », visant à étudier les statuts communaux dans une optique d’histoire sociale, non pas comme une source « normative » mais comme une source de la pratique, de leur matérialité et de leur forme d’écriture aux pratiques sociales en passant par les conditions de leur production et de conservation, leur inscription dans un paysage documentaire communal, leur structure et leur contenu. Ce dernier ouvrage s’intéresse aux statuts « vus de l’extérieur » c’est-à-dire au rapport entre le texte statutaire et sa mise en jeu dans des pratiques sociales concrètes, mais aussi à la manière dont les acteurs médiévaux se posent la question de l’usage de la norme, aux divers moments documentaires où ils font référence ou allèguent explicitement les statuts dans leurs pratiques. Il n’est donc question de statuts qu’à travers d’autres documents, qu’ils fassent partie du paysage documentaire communal (délibérations communales, registres de justice, registres de compte, criées, épigraphie, iconographie, etc.) ou qu’ils soient élaborés en marge des écrits de gouvernement (registres notariés, testaments, récits de miracles, procès de canonisation, sources narratives, chroniques, etc.). Le but est de repérer, d’analyser et d’étudier la manière dont les normes statutaires se sont diffusées – ou pas –, ont été appliquées – ou pas – dans les pratiques politiques, économiques et sociales de la commune : comment ont-elles été validées, reproduites, conservées, diffusées ? C’est l’occasion de mesurer la force pratique des statuts, leurs effets dans la vie quotidienne du gouvernement et des acteurs sociaux, de prouver ainsi la pertinence de la confrontation entre divers éléments textuels produits par la commune pour élaborer une histoire des pratiques sociales à partir des pratiques d’écriture dans les sociétés de la Méditerranée occidentale à la fin du Moyen Âge (XIIe-XVe siècle).
    Keywords: France ; ville ; Italie ; Méditerranée ; Occitanie ; statut ; administration communale ; droit communal ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: French
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    Current Trends and Future Directions in Prosthetic and Implant Dentistry in the Digital Era (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
    Language: English
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    COVID-19: Current Status and Future Prospects (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    The Margins of Late Medieval London, 1430-1540 (2022)
    University of London Press | Institute of Historical Research | University of London Press
    Details
    Publication Date: 2024-04-01
    Description: The Margins of Late Medieval London is a powerful study of medieval London’s urban fringe. Seeking to unpack the complexity of urban life in the medieval age, this volume offers a detailed and novel approach to understanding London beyond its institutional structures. Using a combination of experimental digital, quantitative and qualitative methodologies, the volume casts new light on urban life at the level of the neighbourhood and considers the differences in economy, society and sociability which existed in different areas of a vibrant premodern city. It focuses on the dynamism and mobility that shaped city life, integrating the experiences of London’s poor and migrant communities and how they found their place within urban life. It describes how people found themselves marginalized in the city, and the strategies they would employ to mitigate that precarious position.
    Keywords: middle ages ; marginality ; capital city ; poverty ; London ; London poor ; begging ; refugees ; medieval London ; disease ; prostitution ; sewage ; countryside ; migrant ; migration ; workers ; labour ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: English
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    La ciudad de los monos Roberto Brenes Mesén, los católicos heredianos y el conflicto cultural de 1907 en Costa Rica (2021)
    Editorial Universidad Nacional (EUNA)
    Details
    Publication Date: 2024-04-01
    Description: In 1907, the city of Heredia became the epicenter of the most important religious conflict experienced by Costa Rica in the 20th century. A complaint that the theory of evolution was being taught in the Lyceum (i.e. secondary school) of that city, triggered an increasingly intense confrontation between the Catholic parishioners and the circle of young radical intellectuals articulating around the writer and educator Roberto Brenes Mesén. In the course of this process, Costa Rican society, to the alarm of the government of Cleto González Víquez, was the scene of popular mobilizations in defense of the faith, excommunications and burning of impious texts, while Catholic morality was systematically questioned based on sexual abuse attributed to priests. For a moment, it seemed that the country had gone back in time, and that the ghosts of 1884 were present.
    Keywords: Heredia (Costa Rica) – History – 1907 ; Catholic Church – Heredia (Costa Rica) ; Brenes Mesén, Roberto, 1874-1947 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: Spanish
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    Sobreviure a les presons de Franco: Testimoni epistolar de 1939 a 1943 (2021)
    Publicacions Universitat Rovira i Virgili
    Details
    Publication Date: 2024-04-01
    Description: Aquest estudi sobre la presó franquista de postguerra es basa en les duescentes quaranta cartes que Daniel Vilaró Rius va escriure a la seva família entre juliol del 1939 i agost del 1943 des de tres presons i, per tant, presenta el règim penitenciari viscut des de dins. En aquestes cartes trobem en primera persona l’impacte psicològic de la derrota, dels judicis sumaríssims i de l’empresonament, la por i la incertesa de cada dia, la penúria, la privació emocional de l’allunyament de la família, la frustració de no poder exercir cap rol familiar. Alhora, la voluntat de sobreviure física i moralment, que va ser una voluntat política, i els mecanismes i estratègies que van fer que molts ho aconseguissin, des de l’ajut de fora i la solidaritat a dins, fins a la capacitat de cadascú per mantenir alguna il·lusió i la fe en el futur.
    Keywords: D204-475 ; Guerra Civil espanyola ; presons ; franquisme ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: Catalan
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    Pathogenesis and Targeted Therapy of Epilepsy (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Cross Talk between Lymph Node Lymphatic Endothelial Cells and T Cells in Inflammation and Cancer (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Language: English
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    Ricerche sull'organizzazione del territorio nella Liguria medievale (2021)
    Firenze University Press
    Details
    Publication Date: 2024-04-01
    Description: The organisation of the territory is the outcome of strategies of varying scope, in which a number of agents interact to shape out the areas of operation. The Liguria reality is probed here through four different situations - separated in chronological terms but sharing the poor visibility and limited efficacy of the fortified settlements. These focus on Genoa, both in the definition of its hinterland between the tenth and the eleventh centuries, and in establishing the bulwarks of coastal territorial expansion in the twelfth; the powerful groups of feudal lords who remoulded the rural settlement layout in the thirteenth century; finally, a village of the hinterland explored right through to the modern age.
    Keywords: D111-203 ; Comuni medievali ; Open Access ; Storia ; Societ&agrave ; Liguria ; Signorie ; Medioevo ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
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    Transmucosal Absorption Enhancers in the Drug Delivery Field (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
    Language: English
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    Between State and Church (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-04-01
    Description: The different theoretical notions and practices of the relations between the state and religious communities in early modern Europe constitute one of the most interesting problems in historiography. Moving away from a simple «toleration» versus «non-toleration» dichotomy, the author sets out to analyse the inter-confessional relations in selected European territories in a «longue duree» perspective, between Reformation and Enlightenment. Outlining the relations between the state and the different Churches (confessions) in the Polish-Lithuanian Commonwealth, the Holy Roman Empire of Germany, and the Northern Netherlands serves to highlight the specificity of Northern Netherlands serves to highlight the specificity of «free» (non-absolutist) composite states, where the particularly complex process of defining the raison d’etat determined the level of religious toleration that was politically feasible and socially acceptable.
    Keywords: Church ; Church-state relations ; Confessional ; Denominational relations ; Enlightenment ; Germany ; Humanist and political theory ; Kriegseisen ; Lithuania ; Netherlands ; Poland ; Protestant and Catholic reformers ; Reform ; Reformation ; Relations ; State ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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    Noble conceptions of politics in eighteenth-century Sweden (ca 1740–1790) (2021)
    Finnish Literature Society / SKS
    Details
    Publication Date: 2024-04-01
    Description: "Noble conceptions of politics in eighteenth-century Sweden (ca 1740–1790) is a study of how the Swedish nobility articulated its political ideals, self-images and loyalties during the Age of Liberty and under the rule of Gustav III. This book takes a close look at the aristocracy’s understanding of a free constitution and at the nobility’s complex relationship with the monarchy. Central themes are the old notion of mixed government, classical republican conceptions of liberty and patriotism, as well as noble thoughts on the rights and duties of the citizen, including the right to rebellion against an unrighteous ruler. The study is a conceptual analysis of public and private political statements made by members of the nobility, such as Diet speeches and personal correspondence. The book contributes to the large body of research on estate-based identities and the transformation of political language in the second half of the eighteenth century by connecting Swedish political ideals and concepts to their European context."
    Keywords: upper class ; identity (mental qualities) ; political elite ; ideals ; systems of government ; nobility ; Age of Liberty ; Autocracy ; Finland ; Gustav III of Sweden ; Stockholm ; Sweden ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    Beyond Exceptionalism (2021)
    De Gruyter | De Gruyter Oldenbourg
    Details
    Publication Date: 2024-04-02
    Description: While the economic involvement of early modern Germany in slavery and the slave trade is increasingly receiving attention, the direct participation of Germans in human trafficking remains a blind spot in historiography. This edited volume focuses on practices of enslavement taking place within German territories in the early modern period as well as on the people of African, Asian, and Native American descent caught up in them.
    Keywords: Slavery ; Germany ; Atlantic history ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTQ Colonialism and imperialism ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTR National liberation and independence ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTS Slavery and abolition of slavery
    Language: English
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    Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Language: English
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    Prognostic Factors for Pediatric Tumors (2024)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    Polymer Materials in Biomedical Application (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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    Auf die Tour!: Jüdinnen und Juden in Singspielhalle, Varieté und Kabarett – Habsburgermonarchie bis Amerika (2021)
    Böhlau
    Details
    Publication Date: 2024-04-01
    Description: In the monography Auf die Tour, I analyze the participation of Jews in popular culture in Vienna, Budapest and New York. I argue that entertainment in vaudevilles was shaped between the perception of difference and similarity, between human trafficking, covert prostitution, anti-Semitism and nationalism. Ultimately, my research shows how a space for Jewish-non-Jewish people was created in the coinciding of the mass migration movement and the emerging mass culture between the Habsburg Monarchy and the United States.
    Description: Auf die Tour berichtet von der Teilhabe von Jüdinnen und Juden an der populären Kultur in Wien, Budapest und New York. Zwischen Differenzwahrnehmungen und Ähnlichkeitsdenken, zwischen Menschenhandel, verdeckter Prostitution, Antisemitismus und Nationalismus gestaltete sich Unterhaltung in Varietés. Meine Forschung zeigt, wie sich ein Raum für jüdisch-nichtjüdische Begegnungen in der Massenmigrationsbewegung und der entstehenden Massenkultur zwischen der Habsburgermonarchie und den Vereinigten Staaten ergab.
    Keywords: Jews, fin-de-siècle, Jewish and non-Jewish Relations, cultural exchange, Habsburg Empire, popular entertainment, Vienna, Budapest, New York ; ÖFOS 2012, Regional history ; ÖFOS 2012, Cultural studies ; ÖFOS 2012, Gender studies ; ÖFOS 2012, Global history ; Jüdinnen und Juden, jüdisch-nichtjüdische Beziehungen, kultureller Austausch, Jahrhundertwende, Habsburgermonarchie, Populärkultur, Wien, Budapest, New York ; ÖFOS 2012, Regionalgeschichte ; ÖFOS 2012, Kulturwissenschaft ; ÖFOS 2012, Gender Studies ; ÖFOS 2012, Globalgeschichte ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSR Social groups: religious groups and communities ; thema EDItEUR::5 Interest qualifiers::5P Relating to specific groups and cultures or social and cultural interests::5PG Relating to religious groups::5PGJ Relating to Jewish people and groups
    Language: German
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    Le mouvement hibiste (2023)
    Presses universitaires de Rennes
    Details
    Publication Date: 2024-04-02
    Description: Au début du siècle dernier, le sultan du Maroc vient de signer un traité qui place désormais son pays sous le protectorat de la France (30 mars 1912). À l’ombre du maréchal Lyautey, un sultan de substitution, totalement soumis aux nouveaux maîtres français, a été proclamé. Cependant, nombreux sont ceux qui, au Maroc, refusent le fait accompli et se révoltent face à la mainmise étrangère sur le pays. Ainsi, dans le Sud marocain, Moulay Ahmed el Hiba, fils d’un marabout ouest-saharien (Ma el Aïnin), se fait proclamer sultan du Jihad en 1912 ; une première fois à Tiznit, la seconde à Marrakech. Ces événements ont donné naissance à un mouvement qui pendant plus de vingt ans (1912-1934) symbolisera pour ces populations berbères et ouest-sahariennes la résistance à l’avancée inéluctable des troupes coloniales françaises et espagnoles. Fondée sur une analyse croisée d’archives inédites, aussi bien françaises que marocaines, l’auteur fait la lumière sur un événement fondateur de la conquête coloniale du Maroc. Mythifiée, récupérée ou occultée, la figure fondatrice du mouvement hibiste est encore aujourd’hui le sujet d’un conflit mémoriel ayant pour objet l’Ouest saharien.
    Keywords: Berbères ; colonialisme ; protectorat ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999
    Language: French
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    Zeitgeschichte in Lebensbildern Band 12 (2024)
    Aschendorff Verlag | Aschendorff Verlag
    Details
    Publication Date: 2024-04-01
    Description: Volume 12 contains the biographies of Rainer Barzel (1924-2006), Alfred Dregger (1920-2002), Johannes Dyba (1929-2000), Hermann von Grauert (1850-1924), Paulus van Husen (1891-1971), Richard Jaeger (1913-1998), Thusnelda Lang-Brumann (1880-1953), Amalie Lauer (1882-1950), Franz Meyers (1908-2001), Hermann Platz (1880-1945), Otto B. Roegele (1920-2005), Wilfried Schreiber (1904-1975), Josef Stingl (1919-2004), Arthur F. Utz (1908-2001), Hermann Kardinal Volk (1903-1988), Wilhelm Weber (1925-1983).
    Keywords: history ; biography ; catholic personalities ; german personalities ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999
    Language: German
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    Mary Shelley et le baiser : figures romantiques ? (2023)
    UGA Éditions
    Details
    Publication Date: 2024-04-01
    Description: La figure du baiser occupe une place de choix dans les romans de Mary Shelley (1797-1851), femme de lettres anglaise traditionnellement attachée au courant romantique. Cet ouvrage veut contribuer à la connaissance, encore trop peu développée en France, de cette romancière, par le biais d’une figure littéraire qui entretient un rapport fort à la littérature en général et au romantisme en particulier. Il s’agira d’étudier les modalités de la représentation du baiser dans les sept romans que Mary Shelley produisit entre 1818 et 1837. Figure de la rencontre de deux subjectivités, le baiser se décline sur un mode sensible, mythique et philosophique chez la romancière. Au terme de ce parcours, c’est une figure bien particulière de l’écrivain qui sera (re)découverte.
    Keywords: Frankenstein ; érotique ; esthétique ; éthique ; XIXe siècle ; romancière britannique ; les précieuses ; baiser ; romantisme anglais ; romantique ; littérature féminine ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: French
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    Working At Night (2022)
    De Gruyter | De Gruyter Oldenbourg
    Details
    Publication Date: 2024-04-01
    Description: The night has always and almost universally represented a special ‘out of the ordinary’ temporal zone with its own meanings, possibilities, and dangers. It is only since the modern era that the night has become increasingly ‘normalised’. Although 24/7 industrial production is often seen as a consequence of capitalist expansion, other political and economic regimes adopted the ‘night shift’, normalising it as part of an alternative modernity.
    Keywords: night shift work ; industrial labour ; labour history ; modernity ; 24/7. ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTK Industrialisation and industrial history
    Language: English
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    Athanasius Raczyński (1788–1874). Aristocrat, Diplomat, and Patron of the Arts (2024)
    Brill
    Details
    Publication Date: 2024-03-23
    Description: This book depicts the long rich life and wide ranging work of Count Athanasius Raczyński (1788–1874). By exploring his complex personality, his processes of thought and his accomplishments, it reveals a man at once a wealthy aristocrat, a Pole in the Prussian diplomatic service, an active participant in and perceptive observer and critical commentator on political life, a connoisseur and art collector of European renown, and the author of ground breaking studies on German and Portuguese art – in short a distinguished and fascinating nineteenth century figure.
    Keywords: 19th-century Berlin ; aristocracy ; art collecting ; art historiography ; German painting ; History of collections ; history of diplomacy ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGA History of art ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    Global War, Global Catastrophe (2022)
    Bloomsbury Academic | Bloomsbury Academic
    Details
    Publication Date: 2024-04-02
    Description: Winner of the World War One Historical Association’s 2021 Norman B. Tomlinson, Jr. Prize Global War, Global Catastrophe presents a history of the First World War as an all-consuming industrial war that forcibly reshaped the international environment and, with it, impacted the futures of all the world’s people. Narrated chronologically, and available open access, the authors identify key themes and moments that radicalized the war’s conduct and globalized its impact, affecting neutral and belligerent societies alike. These include Germany’s invasion of Belgium and Britain’s declaration of war in 1914, the expansion of economic warfare in 1915, anti-imperial resistance, the Russian revolutions of 1917 and the United States’ entry into the war. Each chapter explains how individuals, communities, nation-states and empires experienced, considered and behaved in relationship to the conflict as it evolved into a total global war. Above all, the book argues that only by integrating the history of neutral and subject communities can we fully understand what made the First World War such a globally transformative event. This book offers an accessible and readable overview of the major trajectories of the global history of the conflict. It offers an innovative history of the First World War and an important alternative to existing belligerent-centric studies. The ebook editions of this book are available open access under a CC BY-NC-ND 3.0 licence on bloomsburycollections.com.
    Keywords: First World War ; General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR5 First World War ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBF c 1910 to c 1919::3MPBFB c 1914 to c 1918 (World War One period)
    Language: English
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    Movable Inn. The Rural Jewish Population of Minsk Guberniya in 1793-1914 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Description: The book presents the results of a systematic survey, the first of its kind, on the rural Jews in the Minsk Guberniya, from its establishment as a major administrative unit within the Russian Empire in 1793, to the outbreak of the First World War in 1914.
    Keywords: D204-475 ; DJK1-77 ; family structure ; Jews ; demography ; culture ; landlords ; Belarus ; genealogy ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Recent advances in γδ T cell biology: New ligands, new functions, and new translational perspectives (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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    Traditional Medicines and Globalisation (2021)
    Maven Publishers
    Details
    Publication Date: 2022-04-28
    Description: The development of natural products requires the confluence of the modern techniques and integrated approaches in various fields of science and technology. Intention of this book is to highlight different aspects of globalization of traditional medicine with the focus on some crucial and contemporary issues on validation of natural products. Eminent scientists around the globe have contributed for this book on different issues of ethnopharmacology, traditional medicine and globalization. Given the importance on promotion and development of natural products, this book covers various aspects on revitalization of traditional medicines. The contributors have provided an insight into the modem aspects and future of traditional medicine inspired drug development, validation, safety related quality issues, sustainability and globalization. Bringing together expertise from academia and industry, this edited volume provides an overview of traditional medicine with wisdom and know-how in both innovation and commercialization, placing natural product research in a broader sense for readers. This edited volume contains 68 chapters emphasizing several thrust areas of ethnopharmacology and natural products. A wide diversity of chapters has been contributed by eminent personalities throughout the world including Dr. A. P. J. Abdul Kalam, Sri. Shekhar Dutt, Dr. Marco Leonti, Dr. G. A. Cordell, Dr. R. Verpoorte, Dr. P. J. Houghton, Dr. P. Pushpangadan, Dr. Y. K. Gupta, Dr. A.K.S. Rawat, Dr. S.K. Kulkarni, Dr. Colin W. Wright, Dr. S. C. Mandal, Dr. C. K. Katiyar, Dr. T. K. Mukherjee, Dr. S. Rajan, Dr. G. Schemda, Dr. P. K. Debnath, Dr. Bob Alkin, Dr. Elfin Y. Sukandar, Dr. N. Maity, Dr. A. K. Mitra, Dr. E. Hossain, Dr. H. Fukui, Dr. S.Bhadra, Dr. N. Neema, Dr. H. Mizuguchi, Dr. D. Chattopadhyay, Dr. T. Sen, Dr. Erdem Yesilada, Dr. S.K.Mitra, Dr. S.C. Bachar, Dr. S. Karmakar, Dr. G. B. J. Bailly, Dr. P. Haldar, Dr. Y. Oztruk, Dr. S. Pandit, and others. All representing the-state-of-the-art of the field, and thus would be interesting sources for information. This book will be of enormous help to the undergraduate and postgraduate students, researchers and academia and all others working in the area of Ethnopharmacology and natural product research. It will be an imperative addition to the libraries of technical and administrative personnel in the industries and Universities as a potential resource to update their knowledge.
    Keywords: Globalization ; traditional medicine ; bic Book Industry Communication::M Medicine
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    Jugendbewegung, Antisemitismus und rechtsradikale Politik (2022)
    De Gruyter | De Gruyter Oldenbourg
    Details
    Publication Date: 2024-04-01
    Description: The year 2013 marks the centennial of the first "Free-German Youth Day" that took place on the Meissner massif. Anti-Semitic outbursts erupted at the margins of this historical gathering. In its wake, a right-wing populist faction of the youth movement arose for the first time. This collected volume examines the interface between the youth movement, nationalism, and anti-Semitism.
    Keywords: Anti-Semitism ; the youth movement ; right-wing extremism ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPF Political ideologies and movements
    Language: German
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    The Routledge Companion to Global Renaissance Art (2024)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-03-23
    Description: This companion examines the global Renaissance through object-based case studies of artistic production from Africa, Asia, the Americas, and Europe in the early modern period. The international group of contributors take an art historical approach characterized by close analysis of form and meaning as well as function, and a focus on questions of crosscultural dialogue and adaptation. Seeking to de-emphasize the traditional focus on Europe, this book is a critical guide to the literature and the state of the field. Chapters outline new questions and agendas while pushing beyond familiar material. Main themes include workshops, the migrations of artists, objects, technologies, diplomatic gifts, imperial ideologies, ethnicity and indigeneity, sacred spaces and image cults, as well as engaging with the open questions of "the Renaissance" and "the global." This will be a useful and important resource for researchers and students alike and will be of interest to scholars working in art history, visual culture, material culture, and Renaissance studies. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons [Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND)] 4.0 license
    Keywords: Renaissance ; early modern ; art ; art history ; visual studies ; material culture ; objects ; Europe ; Americas ; Africa ; Asia ; Australia ; Oceania ; cross-cultural ; inter-cultural ; global ; colonialism ; colonization ; pre-modern ; geography ; exchange ; trade ; politics ; empire ; influence ; imperialism ; mobility ; cartography ; markets ; courts ; thema EDItEUR::A The Arts::AB The arts: general topics ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGA History of art ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTQ Colonialism and imperialism ; thema EDItEUR::A The Arts::AF The Arts: art forms::AFK Non-graphic and electronic art forms::AFKB Sculpture ; thema EDItEUR::A The Arts::AF The Arts: art forms::AFC Paintings and painting
    Language: English
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    Research Topics in Medicines and How Our Board Members Are Engaged in Them (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Església i franquisme: De la col·laboració amb el franquisme al seu combat (2021)
    Publicacions Universitat Rovira i Virgili
    Details
    Publication Date: 2024-04-01
    Description: Este libro quiere aportar conocimiento y arrojar luz sobre los hechos transcurridos durante la Guerra Civil y tras los años de dictadura, en relación al papel que jugó la Iglesia en esta época histórica. Los lectores verán enseguida cómo las relaciones entre religión y Estado pasaron por diferentes vicisitudes y etapas, y que en puridad deberíamos hablar del papel que jugaron las Iglesias (en plural) o si se prefiere de los papeles (en plural) que jugó la Iglesia. En los largos cuarenta años de la dictadura, la Iglesia sufrió importantes transformaciones, al compás de las que se experimentaban en el tejido social. Los lectores las encontrarán en estas páginas y comprobarán, una vez más, que la historia no se escribe de forma lineal.
    Keywords: D204-475 ; Guerra Civil española ; franquismo ; Iglesia ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: Catalan , Spanish
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    Châteaux et maisons fortes en Lorraine centrale (2022)
    Éditions de la Maison des sciences de l’homme
    Details
    Publication Date: 2024-04-01
    Description: An exhaustive inventory of fortified residences is compared here to written evidence, figurative representations and fieldwork. It retraces the evolution of seigneurial residences of the Xth to XVth centuries. These elements are reinsered into the domaine and social context thanks to the drawing up of unpublished genealogies. In this imposing work a continual contact is maintained between past and present outlining the progress of archaeological research. Actual problems such as the protection of this threatened heritage are also evoked here.
    Keywords: Moyen Âge ; château ; habitat seigneurial ; Lorraine ; maison forte ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: French
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    Akten zur Auswärtigen Politik der Bundesrepublik Deutschland 1974 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    La relación médico-paciente (2021)
    Publicacions i Edicions de la Universitat de Barcelona
    Details
    Publication Date: 2023-12-21
    Description: La relación médico-paciente está sometida a varias presiones. La financiación de la asistencia sanitaria puede determinar tanto la percepción colectiva del acceso a los recursos sociales (prestaciones económicas, centros de atención especializada, ayudas a domicilio, entre otros) como la prescripción de medicamentos y de pruebas complementarias. Además de las prioridades del financiador o de los beneficiarios de los resultados económicos, las campañas publicitarias influyen también en el criterio del paciente, al que la industria farmacéutica halaga convenciéndolo de que posee conocimientos de medicina y de que es un consumidor con el poder de escoger, cuando en realidad decide porque tiene los medios económicos para pagar su elección. En este libro se analizan las razones que empujan a los profesionales de la sanidad hacia una parcialidad interesada, así como las consecuencias éticas que ello tiene sobre el individuo y sobre la eficiencia del sistema sanitario.
    Keywords: R5-920 ; RA1-1270 ; BJ1-1725 ; Relacions metge-pacient ; Medicina ; Dret ; bic Book Industry Communication::M Medicine
    Language: Spanish
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    Inventar der Offenen Befehle der Sowjetischen Militaeradministration des Landes Brandenburg (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-04-01
    Description: Die Publikation ist ein Gemeinschaftsprojekt des Lehrstuhls Geschichte der Militäruniversität des Verteidigungsministeriums der Russischen Föderation (Moskau), des Zentrums für Zeitgeschichte von Bildung und Wissenschaft der Universität Hannover und des Brandenburgischen Landeshauptarchivs (Potsdam). Erstmals wird hier ein Überblick über die im Staatsarchiv der Russischen Föderation in Moskau vorhandene Offene Serie der Befehle der Sowjetischen Militäradministration des Landes Brandenburg – SMAB – gegeben. Einleitend erfolgen quellenkritische und institutionsgeschichtliche Untersuchungen zur Thematik. Den Hauptteil bildet das Inventar der von der Verwaltung der SMAB zwischen 1945 und 1949 erlassenen Offenen Befehle. Auf Interesse dürfte ebenfalls die Übersicht über die von der SMAB erlassenen «Anweisungen» stoßen.
    Keywords: Befehle ; Brandenburg ; Brandenburgisches ; Föderation ; Inventar ; Landes ; Landeshauptarchiv ; Militäradministration ; Offene ; Offenen ; Russischen ; Sowjetischen ; Staatsarchiv ; Überlieferung ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MR 21st century, c 2000 to c 2100 ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPP Public administration
    Language: German
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    Global health issues of aflatoxins in food and agriculture: Challenges and opportunities (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Language: English
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    Emerging Materials for Additive Manufacturing (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Marine Compounds and Cancer (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
    Language: English
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    Diplomatie mit Gefühl. Vertrauen, Misstrauen und die Außenpolitik der Bundesrepublik Deutschland (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Description: Following the Second World War, Germany no longer enjoyed the trust of other nations. What did West Germany do to rebuild confidence? What was the role of trust, mistrust, and supervision during the East-West conflict as West Germany was integrated into the Western alliance, and how did they affect international relations between the two blocs? This study examines personal ties, rhetorical strategies, and institutional connections.
    Keywords: D204-475 ; JZ2-6530 ; DD1-905 ; Foreign policy East-Western conflict Germany ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Personalized Medicine for Parkinson's Disease (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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    Urological Cancer 2022 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    Militaer und Gesellschaft in Preußen – Quellen zur Militaersozialisation 1713–1806 (2022)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-04-01
    Description: Für Alltag, Sozialleben und Erfahrungshorizont der Menschen in der Vormoderne waren militärische Aspekte allgegenwärtig. Das gesellschaftsgeschichtlich ausgerichtete Quelleninventar für die preußische Zentrallandschaft von der Elbe bis zur Oder führt tief in diese Welt. Es stellt eine Arbeitsgrundlage für ein breites historisches Forschungsspektrum zur Verfügung. Dieser erste von drei Teilen enthält eine ausführliche Einleitung mit Benutzungshinweisen und erschließt über 6.000 Archivalien des Brandenburgischen Landeshauptarchivs aus Oberbehörden der Kurmark Brandenburg von 1713 bis 1806.
    Keywords: 1713–1806 ; Archivalien ; Bahl ; Bearbeitet ; Brandenburg ; Brandenburgisches ; Claudia ; Gesellschaft ; Hälfte ; Joafchimsthaler Gymnasium ; Kloosterhuis ; Kurmärkische Domänenkammer ; Kurmärkische Kriegskammer ; Kurmärkisches Kammergericht ; Land ; Landeshauptarchiv ; Militär ; Militärsozialisation ; Nowak ; Peter ; Preußen ; Preußische Militärgeschichte ; Pröve ; Quellen ; Ralf ; Sozialgeschichte Preußens ; Teil ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: German
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    Wie der Krieg ins Museum kam (2022)
    transcript Verlag | transcript Verlag
    Details
    Publication Date: 2024-04-01
    Description: Der »Große Vaterländische Krieg 1941-1945« machte die Mitarbeiterinnen und Mitarbeiter der sowjetischen Museen, die ›muzejsciki‹, zu Akteuren der Erinnerung. An der Front, im Hinterland und in den besetzten Gebieten sammelten sie Relikte von Kämpfen und erlittenem Leid. Ihre zeitnahen und überraschend vielschichtigen Kriegsausstellungen fanden große Resonanz bei den Besucherinnen und Besuchern. Anne E. Hasselmann setzt den Fokus auf die Sammel-, Ausstellungs- und Vermittlungsarbeit der ›muzejsciki‹ am Übergang von Erlebnis zur Erinnerung. Damit eröffnet sie neue Einblicke in die Gesellschaft im Stalinismus und schließt eine Lücke in der Erinnerungsgeschichte des Krieges, der das Selbstverständnis der russischen Gesellschaft bis heute prägt.
    Keywords: Museum ; Sowjetunion ; Zweiter Weltkrieg ; Agency ; Erinnerung ; Russland ; Stalinismus ; Vernichtungskrieg ; Erinnerungskultur ; Geschichte des 20. Jahrhunderts ; Museumswissenschaft ; Zeitgeschichte ; Geschichtswissenschaft ; Soviet Union ; Second World War ; Memory ; Russia ; Stalinism ; Memory Culture ; History of the 20th Century ; Museology ; Contemporary History ; History ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GL Library and information sciences / Museology::GLZ Museology and heritage studies ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies
    Language: German
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    Epigenetics of B Cells and Antibody Responses (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
    Language: English
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    Women and Power at the French Court, 1483-1563 (2021)
    Amsterdam University Press | Pallas Publications
    Details
    Publication Date: 2024-04-01
    Description: Women and Power at the French Court, 1483—1563 explores the ways in which a range of women “ as consorts, regents, mistresses, factional power players, attendants at court, or as objects of courtly patronage “ wielded power in order to advance individual, familial, and factional agendas at the early sixteenth-century French court. Spring-boarding from the burgeoning scholarship of gender, the political, and power in early modern Europe, the collection provides a perspective from the French court, from the reigns of Charles VIII to Henri II, a time when the French court was a renowned center of culture and at which women played important roles. Crossdisciplinary in its perspectives, these essays by historians, art and literary scholars investigate the dynamic operations of gendered power in political acts, recognized status as queens and regents, ritualized behaviors such as gift-giving, educational coteries, and through social networking, literary and artistic patronage, female authorship, and epistolary strategies.
    Keywords: History ; women ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
    Language: English
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    Enklaven (2022)
    De Gruyter | De Gruyter Oldenbourg
    Details
    Publication Date: 2024-04-02
    Description: Die Bezeichnung „Enklave“ wird für unterschiedliche Phänomene und Prozesse verwendet. Enklaven sind in sozialer, politischer oder wirtschaftlicher Hinsicht von den sie umgebenden Räumen wie Nationalstaaten, Städten oder Wirtschaftssektoren abgegrenzt. Enklaven umschließen soziokulturelle Minderheiten, „Staaten im Staate“ oder Produktionszonen, die den Interessen auswärtiger Akteure oder bestimmter Interessengruppen dienen. Innerhalb von Enklaven gelten eigene Regeln. Dieser Band beleuchtet Enklavenbildung am Beispiel der Förderung von Rohstoffen in Afrika
    Keywords: Enclaves ; Raw Materials ; Africa ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Saúde, trabalho e formação profissional (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Reúne textos de especialistas das áreas de Saúde e de Educação com longa, competente e comprometida atuação na luta por mudanças sociais, preocupados com um (con)viver humano mais solidário. A obra mostra ser possível a constituição de serviços de saúde com profissionais sensíveis e preparados para atuar em tempos de novas exigências técnicas e de capacitação profissional. Por instigar a (re)pensar o aperfeiçoamento técnico e ético do trabalho, com idéias e propostas originais e atuais, trata-se, certamente, de contribuição de relevância para aqueles que, direta ou indiretamente, encontram-se engajados na causa do Sistema Único de Saúde.
    Keywords: R5-920 ; Pessoal técnico de saúde-educação ; Ocupação em saúde ; educação profissional ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Deutsche und polnische Juden vor dem Holocaust. Jüdische Identität zwischen Staatsbürgerschaft und Ethnizität 1933-1940 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Handwerk und Kleinhandel in der Bundesrepublik Deutschland. Sozialökonomischer Wandel und Mittelstandspolitik 1949–1961 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Immune responses to AAV vectors, from bench to bedside (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
    Language: English
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    Racism in Modern Russia (2022)
    Bloomsbury Academic | Bloomsbury Academic
    Details
    Publication Date: 2024-04-02
    Description: In October 2013, one of the largest anti-migrant riots took place in Moscow. Clashes and arrests continued late into the night. Some in the crowd, which grew to several thousand people, could be heard chanting “Russia for the Russians” with their animus directed towards dark-skinned labor migrants from the southern border. The slogan “Russia for the Russians” is not a recent invention. It first gained notoriety in the very last years of the tsarist regime, appealing primarily to individuals drawn to the radical right. Analyzing a wide range of printed and visual sources, Racism in Modern Russia marks the first serious attempt to understand the history of racism over a span of 150 years. A brilliant examination of the complexities of racism, Eugene M. Avrutin’s panoramic book asks powerful questions about inequality and privilege, denigration and belonging, power and policy, and the complex historical links between race, whiteness, and geography. The ebook editions of this book are available open access under a CC BY-NC-ND 4.0 license on www.bloomsburycollections.com.
    Keywords: Society ; culture ; racial studies ; race ; prejudice ; hate crimes ; modern history ; Russian history ; social history ; discrimination ; anti-racism ; anti-racist ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MR 21st century, c 2000 to c 2100
    Language: English
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    Meine Vertreibung aus Prag. Erinnerungen an den Prager Aufstand 1945 und seine Folgen (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Die Kreuzfahrerstaaten als multikulturelle Gesellschaft. Einwanderer und Minderheiten im 12. und 13. Jahrhundert (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Description: Das international besetzte Kolloquium vom September 1994 widmete sicheinem zuvor vernachlässigten Thema. Es ist eine wesentliche Erkenntnisdes Kolloquiums, daß die Einwanderung - die hier untersucht wird fürden Adel, die Kirche, die Zentralverwaltung, die Wirtschaft und dieKunst - die Kreuzfahrerstaaten vor intellektueller und kulturellerVersteinerung bewahrte und sie auf der Höhe der europäischenEntwicklung hielt. Bei den Minderheiten zeigen mehrere Beiträge dieSchwierigkeiten im Zusammenleben mit den lateinischen Eroberern, mitdenen man trotz aller Abneigung zu fragilen Symbiosen kommen mußte.
    Keywords: D111-203 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: English , French , German
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    Deutsche in Polen nach 1945. Gefangene und Fremde (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Chapter 4 Quarantine in Ceuta and Malta in the travel writings of the late-eighteenth-century Moroccan ambassador Ibn Uthmân Al-Meknassî (2021)
    Manchester University Press | Mediterranean quarantines, 1750–1914: Space, identity and power
    Details
    Publication Date: 2024-04-02
    Description: This chapter examines the writings of the renowned late-eighteenth-century Moroccan ambassador Ibn Uthmân Al-Meknassî, the first known traveller from his country to leave an account of European quarantine as experienced during his two diplomatic missions in Spain’s Ceuta (1779) and Malta’s Valletta (1782). It shows that quarantine, on the one hand, acted as a marker of otherness by which Ibn Othman was identified as a Muslim, though this was not a uniform process, owing to the fact that significant differences existed in the degree of alterity experienced in Spain and Malta, and indeed other parts of the Mediterranean. The subjective opinion on quarantine, on the other hand, was also one of the means through which Ibn Uthmân situated himself within Makhzen (Moroccan government) elites at a time when a division between those who declared themselves in favour of European-style modernisation and those who advocated a rejection of European novelties was already visible.
    Keywords: ibn uthmân al-meknassî ; spain ; diplomatic missions ; morocco ; 18th century ; quarantine ; malta ; muslim identity ; ibn uthmân al-meknassî ; spain ; diplomatic missions ; morocco ; 18th century ; quarantine ; malta ; muslim identity ; Ceuta ; Epidemic ; Mediterranean Sea ; Tangier ; Travel literature ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::J Society and Social Sciences ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBX History of medicine
    Language: English
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    An Equal Burden (2021)
    Oxford University Press
    Details
    Publication Date: 2024-04-01
    Description: "An Equal Burden forms the first scholarly study of the Army Medical Services in the First World War to focus on the roles and experiences of the men of the ranks of the Royal Army Medical Corps (RAMC). These men, through their work as stretcher bearers and orderlies, provided a range of labour, both physical and emotional, in aid of the sick and wounded. They were not professional medical caregivers, yet were called upon to provide medical care, however rudimentary; they served in uniform, under military discipline, yet were forbidden, as non-combatants, from carrying weapons. Their service as men in wartime, was thus unique. Structured both chronologically and thematically, this study examines both the work that RAMC rankers undertook and its importance to the running of the chain of medical evacuation. It additionally explores the gendered status of these men within the medical, military and cultural hierarchies of a society engaged in total war, locating their service within the context of that of doctors, female nurses and combatant servicemen. Through close readings of official documents, personal papers, and cultural representations, both verbal and visual, it argues that the ranks of the RAMC formed a space in which non-commissioned servicemen, through their many roles, defined and redefined medical caregiving as men’s work in wartime."
    Keywords: Royal Army Medical Corps ; First World War ; masculinity ; non-combatants ; military medicine ; care giving ; gender history ; cultural representation ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR5 First World War ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBF c 1910 to c 1919::3MPBFB c 1914 to c 1918 (World War One period) ; thema EDItEUR::M Medicine and Nursing
    Language: English
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    Marine Natural Products as Anticancer Agents 2.0 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Chapter Russia in the Global Parliamentary Moment, 1905–1918: Between a Subaltern Empire and an Empire of Subalterns (2022)
    De Gruyter | De Gruyter Oldenbourg
    Details
    Publication Date: 2024-04-02
    Description: This volume adds to the plurality of global histories by locating the global through its articulation and manifestation within particular localities. It accomplishes this by bringing together interlinked case-studies that analyse various temporal and spatial dimensions of the global in the local and the interactions between the local and the global.
    Keywords: Anti-colonialism ; Memory rooms ; Representative rooms ; Translocality ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCZ Economic history
    Language: English
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    CD4+ T cell differentiation in infection: amendments to the Th1/Th2 axiom (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Les faiseurs de notes (2022)
    Éditions Universitaires d’Avignon
    Details
    Publication Date: 2024-04-01
    Description: Qu’est-ce qu’être musicien au XVIIIe siècle ? Dans un livre qui se lit comme un roman, Aurélien Gras restitue avec finesse et sensibilité l’univers social et professionnel de ces artistes d’Ancien Régime, qu’ils soient compositeurs ou interprètes. À partir de minutieuses recherches dans les fonds d’archives provençaux, de Marseille à Arles, en passant par Aix et Avignon, l’auteur fait résonner leurs notes partout, de l’église à la rue, du théâtre aux noces de quartier. Dans cette Provence moderne, les lecteurs verront aussi surgir tout un pan de la vie sociale, encore trop ignoré. Prenons donc plaisir à découvrir les conditions d’exercice d’un métier à la fois essentiel et marginal dans une société d’ordres qui ne pouvait subsister sans se célébrer en musique.
    Keywords: French local history ; musician ; 18th century ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: French
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    Neumaerkische Staende (Rep. 23 B) (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-04-01
    Description: Die Publikation gibt einen umfassenden und detaillierten Überblick über den im Brandenburgischen Landeshauptarchiv befindlichen Bestand der Neumärkischen Stände. Die aus dem 16.-19. Jahrhundert stammende Überlieferung wird für jede Akteneinheit durch die Angabe des präzisen Aktentitels und der Laufzeit in einer klaren, nach Sachgebieten systematisch gegliederten Ordnung beschrieben. Die umfangreiche historische Einleitung analysiert Organisation und Wirkungsbereiche der Neumärkischen Stände und stellt in vergleichender Perspektive die bislang vernachlässigte Aussagekraft der Quellen für die frühneuzeitliche Ständegeschichte Deutschlands und Ostmitteleuropas heraus.
    Keywords: Bearbeitet ; Beck ; eingeleitet ; Margot ; Neugebauer ; Neumärkische ; Stände ; Wolfgang ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Humanidades Digitales (2022)
    De Gruyter | De Gruyter
    Details
    Publication Date: 2024-03-26
    Description: The contributions gathered in this volume show how digital technologies can be applied to Medieval Studies (Philology, Art, and History) in order to improve our understanding of medieval societies and cultures.
    Keywords: Corpus Analysis ; Digital Humanities ; Digital History ; Middle Ages ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBB Literary studies: ancient, classical and medieval ; thema EDItEUR::N History and Archaeology::NH History::NHA History: theory and methods ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: Spanish , Portuguese
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    Communicating Medicine (2021)
    Ledizioni
    Details
    Publication Date: 2023-12-21
    Description: This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types. The texts examined in the study are representative of their authors’ effort to expand medical knowledge and to define medicine as an independent science based on strict observation, as well as to establish intelligibility within and outside the disciplinary discourse community.
    Keywords: R5-920 ; english ; medicine ; language ; communication ; bic Book Industry Communication::M Medicine
    Language: English
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    Un désordre européen (2022)
    Éditions de la Sorbonne
    Details
    Publication Date: 2024-04-01
    Description: Aux xvie et xviie siècles, l’ordre européen était parfois menacé par des crises d’origine régionale. Ces désordres venaient des initiatives scandaleuses d’acteurs politiques habituellement peu présents sur la scène internationale (municipalités, institutions provinciales, seigneurs locaux). Pour résoudre des conflits internes, parfois contre leur propre souverain, ces acteurs n’hésitaient pas à appeler des puissances étrangères à leur secours, dans des logiques de solidarités politico-religieuses internationales. Les « affaires de Provence» (1580-1598) permettent de comprendre le fonctionnement de ce type de crises. Au plus fort des guerres de Religion en France, les catholiques de Provence appelèrent à leur secours le duc de Savoie, le grand-duc de Toscane, les papes et le roi d’Espagne. Parce que la Provence avait une position stratégique entre Barcelone et Gênes, d’autres puissances intervinrent à leur tour: l’Angleterre, l’Empire ottoman, le duché de Lorraine et la République de Venise. À partir d’une étude minutieuse des événements, ce livre mène une réflexion approfondie sur les défis stratégiques, intellectuels et rhétoriques d’une situation vécue à l’époque comme un désordre international, en raison de la marge de manœuvre subversive acquise par des acteurs ordinairement faibles.
    Keywords: politique ; diplomatie ; gouvernement ; guerre de religion ; crise politique ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: French
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    Três ensaios de bioética (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Leitores interessados no desenvolvimento teórico da bioética e, ao mesmo tempo, em sua aplicação na solução de conflitos morais certamente encontrarão neste livro materiais de grande valor. Cada capítulo coloca a bioética em um contexto diferente: na clínica, na genômica e na biossegurança. No primeiro ensaio, discutem-se as possibilidades dessa ‘caixa de ferramentas’ chamada bioética para compreender e tentar resolver conflitos de interesses e valores no âmbito das relações entre profissionais e usuários dos serviços de saúde. No segundo, o autor aplica as ferramentas da bioética ao caso dos conflitos morais que envolvem a genômica, contemplando argumentos favoráveis e contrários às práticas da engenharia genética e contribuindo para o raciocínio crítico e sem preconceitos sobre o tema. Por fim, o terceiro capítulo trata da interface entre a bioética e a biossegurança, que têm preocupações comuns, como a questão dos riscos, mas abordagens distintas – enquanto a bioética se ocupa dos valores morais, a biossegurança lança mão de medidas técnicas, administrativas e legais.
    Keywords: R5-920 ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-02-01
    Description: Extracellular vesicles (EVs) are particles wrapped in a lipid bilayer membrane and are naturally released from cells. This kind of cargo vessel is a nanostructure that mainly transfers lipids, proteins, various nucleic acid fragments, and metabolic components to neighboring cells or distant parts of the body through the circulatory system. EVs are of great significance to the communication mechanism between cells. This book collects feature articles to enhance our understanding of the biological characteristics of EVs and their potential applications.
    Keywords: extracellular vesicle ; precision oncology ; cancer biomarker ; prostate cancer ; drug delivery ; extracellular vesicles ; lysosome ; nanocarriers ; ultrasound ; size exclusion chromatography ; differential ultracentrifugation ; head and neck squamous cell carcinoma (HNSCC) ; exosomes ; cancer ; biomarker ; diagnostic ; therapy ; liquid biopsy ; small extracellular vesicles (sEV) ; tumor-derived exosomes (TEX) ; melanoma cell-derived exosomes (MTEX) ; proteomics ; tumor microenvironment ; biomarkers ; ectosomes ; neoplasia ; microvesicles ; small extracellular vesicles ; isolation ; purification ; size-exclusion chromatography ; ultracentrifugation ; sucrose density cushion ; lymph node ; spleen ; solid tissue ; microvesicle ; exosome ; cancer therapeutic ; drug carrier ; flow cytometry ; immunophenotyping ; swarm detection ; tumor-associated macrophages ; macrophage polarization ; mannose receptor ; HIV-1 Nef ; glioblastoma ; microRNA ; immunoprecipitation ; CD44 ; human milk ; nutrient ; microbiota ; microRNAs ; nanocommunicator ; diagnostic biomarker ; drug delivery vehicle ; personalized cancer immunotherapy ; therapeutic agents ; cell-to-cell communication ; ionising radiation ; non-targeted effects ; signalling ; imaging flow cytometry ; biomarker reservoirs ; cancer diagnostics ; disease monitoring ; large EVs ; ovarian cancer cells ; ES-2 ; OAW-42 ; adipose tissue origin mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Lipid Signaling in T Cell Development and Function (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
    Keywords: R5-920 ; RC581-607 ; eicosanoid ; Inositol ; diacylglyerol ; PI3K ; Vitamin D ; T cell ; SHIP ; Pten ; Adipokine ; Lipid ; bic Book Industry Communication::M Medicine
    Language: English
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    Foundations of Paleoparasitology (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Unprecedented initiative in the world, the book compiles the available knowledge on the subject and presents the state-of-the-art in paleoparasitology – term coined about 30 years ago by Brazilian Fiocruz researcher Luiz Fernando Ferreira, pioneer in this science which is concerned with the study of parasites in the past. Multidisciplinary by essence, paleoparasitology gathers contributions from social scientists, biologists, historians, archaeologists, pharmacists, doctors and many other professionals, either in biomedical or humanities fields. With varied applications such as in evolutionary or migration studies, their results often depend on the association between laboratory findings and cultural remains. The book is divided into four parts - Parasites, Hosts, and Human Environment; Parasites Remains Preserved in Various Materials and Techniques in Microscopy and Molecular Diagnostics; Parasite Findings in Archeological Remains: a paleographic view; and Special Studies and Perspectives. Signed by authors from various countries such as Argentina, USA, Germany and France, the book has chapters devoted to the discoveries of paleoparasitology on all continents.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: English
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    Okkupation im Osten. Besatzeralltag in Warschau und Minsk 1939-1944 (2021)
    De Gruyter
    Details
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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    Vietnam Task (2023)
    ANU Press | ANU Press
    Details
    Publication Date: 2024-04-02
    Description: On 24 May 1966, eight hundred men of the 5th Battalion, The Royal Australian Regiment, landed at Nui Dat, in Viet Cong territory. For the next 12 months they were faced with the task of restoring peace, civil law and regular commerce to the Vietnamese of Phuoc Tuy province. This book is a detailed record of those months in the monsoon jungles—of the problems that were faced and the solutions that were found. Captain O’Neill’s position as battalion intelligence officer enabled him to view the war from the standpoint of the battalion as a whole. However, he does not omit description of personal feelings—towards the Viet Cong, the jungle environment and the Vietnamese people, as well as the other Allied forces involved in the war. Most of the book was written on the spot in Vietnam. On operations or at Battalion Headquarters, Captain O’Neill jotted down details of the war against the Viet Cong, putting the events of each day in order, often in the small hours of the following morning. Thus not only is this a factual account of the 5th Battalion’s activities over the year; it is also a vivid and compelling picture of the war in Vietnam from the soldier’s point of view.
    Keywords: 5th Battalion ; Royal Australian Regiment ; 5RAR ; Vietnam War ; Viet Cong ; Vietnam ; thema EDItEUR::N History and Archaeology::NH History::NHM Australasian and Pacific history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR9 Military history: post-WW2 conflicts ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWL Modern warfare ; thema EDItEUR::1 Place qualifiers::1F Asia::1FM South East Asia::1FMV Vietnam ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPQ Later 20th century c 1950 to c 1999
    Language: English
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    Advances in the Diagnosis and Treatment of Thyroid Carcinoma (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-10-25
    Description: This reprint is related to the latest research in the field of thyroid surgery, including molecular and imaging diagnosis, surgical treatment, and the treatment of recurrent disease and advanced thyroid carcinoma.
    Keywords: thyroid carcinoma ; prophylactic central lymph node dissection ; lymph node metastases ; RET ; medullary thyroid carcinoma ; clinical management ; variants of uncertain significance ; differentiated thyroid cancer ; papillary thyroid cancer ; minimal extrathyroidal extension ; radioactive iodine therapy ; prognosis ; TNM ; histology ; multifocality ; lymph node metastasis ; vascular invasion ; autoimmune thyroid diseases ; radioiodine refractory ; Lenvatinib ; 18F-FDG-PET/CT ; cost-benefit analysis ; economics ; medical ; thyroid neoplasms ; radiomics ; ultrasound ; magnetic resonance imaging ; computer tomography ; prediction ; classification ; angiogenic microenvironment ; prognostic factors ; antiangiogenic therapy ; therapeutic target ; tumor microenvironment ; tumor behavior ; proliferation pathways ; cell cycle control pathways ; angiogenesis process ; thyroid cancer ; Gal-3 expression ; NIFTP ; EFVPTC ; lymphocytic thyroiditis (LT) ; immunohistochemical (IHC) analysis ; molecular imaging ; theranostics ; companion diagnostics ; immunoPET ; anaplastic thyroid cancer ; poorly thyroid cancer ; genetic landscape ; genetically guided therapy ; fluorodeoxyglucose F18 (18F-FDG) ; positron emission tomography (PET) ; magnetic resonance imaging (MRI) ; recurrence ; neoplasm metastasis ; thyroid surgery ; hypoparathyroidism ; fluorescence-guided surgery ; near-infrared autofluorescence ; PRKAR1A ; PKA ; Carney complex ; cAMP ; bone metastasis ; metastasectomy ; stereotactic radiosurgery ; ultrasound imaging ; thyroid nodule ; fine-needle aspiration ; papillary thyroid carcinoma ; lobectomy ; operative extent ; CONUT score ; tyrosine kinase inhibitors ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    A Companion to the Cavendishes (2020)
    Arc Humanities Press
    Details
    Publication Date: 2024-03-27
    Description: “The noble Cavendishes were one of the most influential families in the politics and culture of early modern England and beyond. A Companion to the Cavendishes offers a comprehensive account of the Cavendish family's creative output and cultural significance in the seventeenth century. It discusses the writings of individuals including William and Margaret Cavendish, and William's daughters Jane and Elizabeth; family members' work and patronage in other media such as music, architecture, and the visual arts; their participation in contemporary developments in politics, philosophy, and horsemanship; and the networks in which they moved both in England and in continental Europe. It also covers the work of less well-known family members such as the poet and biographer George Cavendish and the composer Michael Cavendish. This volume combines path-breaking scholarship with discussion of existing research, making it an invaluable resource for all those interested in this fascinating and diverse group of men and women.”
    Keywords: literary culture; aristocratic life; women’s writing; closet drama; iconography ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    Clémenceau et la justice (2022)
    Éditions de la Sorbonne
    Details
    Publication Date: 2024-04-01
    Description: Pour commémorer le cinquantenaire de la mort de George CLEMENCEAU, la Société des Amis de Georges Clemenceau organisa, en décembre 1979, au Palais du Luxembourg — dans les locaux du Sénat, qu’il avait marqué de sa puissante empreinte — un colloque historique international, animé par J. B. DUROSELLE. Son thème : « Clemenceau et la Justice » a été maintenu dans le présent ouvrage, car parmi toutes les facettes de la personnalité si riche, à travers toutes les péripéties de la vie et de la carrière, si longue, de Georges Clemenceau, on trouve constamment cette soif insatiable de justice. Les qualités des communications et de leurs auteurs, venus de divers horizons, montrent toute la vigueur des études clemencistes, qu’elles contribuent sans prétendre à une impossible exhaustivité, à puissamment renouveler. Cela suffit à expliquer la présente publication.
    Keywords: biographie ; politique ; gouvernement ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999
    Language: French
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    Biomedical Insights that Inform the Diagnosis of ME/CFS (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Keywords: R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.
    Keywords: R5-920 ; RC648-665 ; RC321-571 ; Q1-390 ; HPA axis ; Vulnerability ; resilience ; early life stress ; materna ; bic Book Industry Communication::M Medicine
    Language: English
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