ALBERT

Description / Table of Contents: Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling -- Overview of Basic Mechanisms of Notch Signaling in Development and Disease -- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate -- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling -- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster -- Molecular Regulation of Notch Signaling by Gremlin -- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex -- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss -- Insulin–dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation -- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF-κB and beyond -- Index.

Description / Table of Contents: Neurosecretion: A Historical Overview -- Neurosecretion: Hypothalamic Somata versus Neurohypophysial Terminals -- Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus -- Somato-Dendritic Secretion of Neuropeptides -- Neurosecretory Vesicles: Structure, Distribution, Release and Breakdown -- Molecular Controls on Regulated Neurotransmitter and Neurohormone Secretion -- Secretory Astrocytes -- Action Potential-Induced Ca2+ Influx for Both Acute and Sustained Insulin Secretion in Pancreatic Beta Cells -- Plasticity in the Morphology of Lactotrophs and Folliculo-Stellate Cells and Prolactin Secretion -- Neuroendocrine and Metabolic Regulation of Plasma Growth Hormone Secretory Profiles -- Role of the TWIK-Related Potassium (TREK)-1 Channels in the Regulation of Adrenocorticotropic Hormone (ACTH) Secretion from Pituitary Corticotropes -- How Do Bacterial Neurotoxins Affect Neurosecretion? -- Secretory Mechanisms in Paramecium.

Description / Table of Contents: MicroRNAs in the tumor microenvironment -- The Impact of Estrogen in the Tumor Microenvironment -- The non-bone related role of RANK/RANKL signaling in cancer -- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment -- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma -- COX-2 Signaling in the Tumor Microenvironment -- Renin–angiotensin system in the tumor microenvironment -- Stem cell secreted factors in the tumor microenvironment -- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy -- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms -- Index.

Description / Table of Contents: Chapter 1: Introduction -- Chapter 2: Origin and development of the breast -- Chapter 3: Structure of the lactating breast -- Chapter 4: Breast function during the initial period of lactation (lactogenesis I and II) -- Chapter 5: The period of established lactation (lactogenesis III).

Description / Table of Contents: Bioanalytical Support in Drug Discovery and Development,- Monoclonal Antibodies -- Antibody Drug Conjugates (ADCS) -- Bispecifics and Fusion Proteins -- Emerging Modalities-Part A- (Gene Therapy and Cell Therapy) -- Emerging Modalities Part B (Peptides, Oligonucleotide Based Therapy, Vaccines. .

Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Unconventional functions of transcription factors -- GAGA transcription factor -- Heterochromatin protein 1 -- Retinoblastoma protein -- STAT -- ATF-2 -- NF-kB -- Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer -- STAT and HP1 promote longevity -- STAT and HP1 protect against DNA damage -- Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model -- Chapter 4 The possible biological significance of transcription factors’ unconventional functions -- The epigenome -- Processes in the cell nucleus -- Future Work.

Description / Table of Contents: Chapter 1. Introduction -- PART I: Photosynthesis and Biomass Production under Changing World -- Chapter 2. Climate Change: Challenges to Reduce Global Warming and Role of Biofuels -- Chapter 3. The multifaceted connections between photosynthesis and mitochondrial metabolism -- Chapter 4. Regulation of assimilatory processes and distribution of energy for improved productivity -- Chapter 5. Strategies to enhance photosynthesis for the improvement of crop yields -- Chapter 6. Photosynthetic Acclimation and Adaptation to Cold Ecosystems -- Chapter 7. What is the limiting factor? – The key question for grain yield of maize as a renewable resource under salt stress -- PART II: Microalgae and engineered crops for production of biofuels and high-value products -- Chapter 8. Bio-production from microalgal resources -- Chapter 9. Hydrogen photoproduction in green algae: novel insights and future perspectives -- Chapter 10. Synthetic Biofuels and Green-House Gas Mitigation -- Chapter 11. Synthetic biology and future production of biofuels and high-value products -- PART III: Genetic resources and engineering methods to improve crop plants -- Chapter 12. Kinetics, genetics and heterosis -- Chapter 13. Genome information resources to improve plant biomass productivity -- Chapter 14. RNA interference: formproving traits and disease management in plants -- Chapter 15. Current transformation methods for genome editing applications in energy crop sugarcane -- Chapter 16. Development of transgenic sugarcane for insect resistance -- Chapter 17. Rapid Agrobacterium-mediated transformation of tobacco cotyledons using toothpicks Yuan-Yeu Yau, Mona Easterling and Lindsey Brennan -- Chapter 18. Genetic improvement of Jatropha curcas through conventional and biotechnological tools -- Chapter 19. Plant cell manipulation technology for bio-refinery. .

Description / Table of Contents: Chapter 1: Introduction: Fluorescent materials for cell imaging -- Chapter 2: Semiconductor quantum dots for cell imaging -- Chapter 3: Carbon nanodots for cell imaging -- Chapter 4: Silicon nanoparticles for cell imaging -- Chapter 5: Fluorescent metal nanoclusters for bioimaging -- Chapter 6: Lanthanide-based upconversion nanoparticles for bioimaging applications -- Chapter 7: Conjugated polymers and polymer dots for cell imaging -- Chapter 8: Aggregation-induced emission (AIE) probes for cell imaging -- Chapter 9: Luminescent coordination compounds for cell imaging.

Description / Table of Contents: Introduction to genes, oncogenes, and anti-oncogenes -- Introduction to free radicals (including nitric oxide), antioxidants, lipid peroxidation and their effects on cell proliferation -- Immune system, inflammation and essential fatty acids and their metabolites in cancer -- PUFAs and their metabolites in carcinogenesis -- Molecular mechanism of anti-cancer action of PUFAs with particular reference to GLA in glioma -- Bioactive lipids (BAL)-based therapeutic approach to cancer that enhances anti-tumor action and ameliorates cytokine release syndrome of immune check point inhibitors -- A new therapeutic strategy to treat cancer based on bioactive lipids (BAL) -- Index.

Description / Table of Contents: Live Donors of Tissue -- Deceased Tissue Donors -- Banking and Use of Umbilical Cord Blood -- Ocular tissue banking -- Banking of Heart Valves -- Cryopreservation and Banking of Haematopoietic Progenitor Cells -- Storage, Processing and Preservation -- Cryopreservation in tissue banking -- Sterilisation by Irradiation -- Screening the tissue donor for infectious agents -- Contamination in the Tissue Way -- Establishing a Quality System in a Tissue Establishment -- IT System requirements for Tissue and Cell Banking -- Ethical and Regulatory Aspects of Cell and Tissue Banking -- Human embryonic stem cell banking for clinical applications – 20 years from their isolation.

Description / Table of Contents: Chapter 1:Introduction: Historical Development and Progression of Clinical Research on Ageing -- Chapter 2:Bone Cells Metabolic Changes Induced by Ageing -- Chapter 3:Chronic Inflammation as an Underlying Mechanism of Ageing and Ageing-related Diseases -- Chapter 4: Heart Disease and Ageing: The roles of Senescence, Mitochondria and Telomerase in Cardiovascular Disease -- Chapter 5: Chronic Kidney Disease and the Exposome of Ageing -- Chapter 6: Sarcopenia and Ageing -- Chapter 7: Tendon Ageing -- Chapter 8: Virus Infections in Older People -- Chapter 9: Models and Biomarkers for Ovarian Ageing -- Chapter 10: Ageing and the Autonomic Nervous System -- Chapter 11: Astrocytes in Ageing -- Chapter 12: Hearing and Ageing -- Chapter 13: Melatonin and Ageing -- Chapter 14: Protein and Energy Supplements for the Elderly -- Chapter 15: Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants -- Chapter 16: Clinical Ageing.

Description / Table of Contents: Introduction -- Batch Processing Methods in ImageJ -- Python: Data Handling, Analysis and Plotting -- Building a Bioimage Analysis Workflow Using Deep Learning -- GPU-Accelerating ImageJ Macro Image Processing Workflows Using CLIJ -- How to Do the Deconstruction of Bioimage Analysis Workflows: A Case Study with SurfCut -- i.2.i. with the (Fruit) Fly: Quantifying Position Effect Variegation in Drosophila Melanogaster -- A MATLAB Pipeline for Spatiotemporal Quantification of Monolayer Cell Migration.

Description / Table of Contents: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.

Description / Table of Contents: Chapter 1. A Systemic View of Metastatic Disease: Inter-organ Crosstalk and Therapeutic Implications -- Part I. Systemic Regulation in Metastatic Disease -- Chapter 2. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles -- Chapter 3. Bone Metastasis: Systemic Regulation and Impact on Host -- Chapter 4. Targeting Metastatic Disease: Challenges and New Opportunities -- Part II. Cachexia: A Debilitating Systemic Effect of Cancer -- Chapter 5. Signaling Pathways That Promote Muscle Catabolism in Cachexia -- Chapter 6. The Role of Interleukin-6 Cytokines in Cancer Cachexia -- Chapter 7. NF-kB Signaling in the Macroenvironment of Cancer Cachexia -- Part III. Therapy-induced Muscle Wasting -- Chapter 8. Therapy-induced Toxicities Associated with the Onset of Cachexia -- Chapter 9. Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy -- Part IV. Preventing and Targeting Cachexia in Cancer -- Chapter 10. New Developments in Targeting Cancer Cachexia -- Chapter 11. Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer.

Description / Table of Contents: Preface -- Amino acids in intestinal physiology and health -- Amino acid metabolism in the liver: nutritional and physiological significance -- Amino acids in circulatory function and health -- Epithelial dysfunction in lung diseases: effects of amino acids and potential mechanisms -- Amino acid metabolism in the kidneys: nutritional and physiological significance -- Amino acids in health and endocrine function -- Amino Acids in Reproductive Nutrition and Health -- Impacts of amino acids on the intestinal defensive system -- Maternal nutrient restriction and skeletal muscle development: Consequences for postnatal health -- Metabolism of amino acids in the brain and their roles in regulating food intake -- Metabolism and functions of amino acids in the skin -- Metabolism and functions of amino acids in sense organs. .

Description / Table of Contents: Preface -- Part 1 Basics on coenzyme Q -- Introduction. The current coenzyme Q science and knowledge -- Molecular structure, biosynthesis, and distribution of coenzyme Q -- Coenzyme Q function in mitochondria -- Extramitochondrial coenzyme Q10 in aging -- Regulation of the synthesis of Coenzyme Q10 -- Part 2 Coenzyme Q in aging studies -- Coenzyme Q and aging in C. elegans -- Coenzyme Q and aging in the fruit fly Drosophila melanogaster -- The aging process and coenzyme Q: clk-1 mouse models -- Reduced coenzyme Q10 decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions -- Part 3 Age-related diseases and coenzyme Q -- Coenzyme Q, mtDNA and mitochondrial dysfunction during aging -- Coenzyme Q10 and metabolic syndrome -- Coenzyme Q and age-related neurodegenerative disorders: Parkinson and Alzheimer diseases -- Immunosenescence and CoQ10 -- Coenzyme Q10 in fertility and reproduction -- Part 4 Prolongevity effectors and Coenzyme Q -- Calorie restriction, longevity and coenzyme Q -- Age dependent changes of coenzyme Q levels and its induction in experimental systems -- Effects of coenzyme Q10 supplementation on elderly people -- Index.

Description / Table of Contents: Part 1 Pigments and pigment organelles -- 1 Pigments in insects -- 2 Melanins in vertebrates -- 3 Body color expression in birds -- 4 Pigments in teleosts and their biosynthesis -- 5 Bioluminescence and Pigments -- Part 2 Pigment cell and patterned pigmentation -- 6 Development of melanin-bearing pigment cells in birds and mammals -- 7 Pigment cell development in teleosts -- 8 Pigment patterning in teleosts -- 9 Theoretical studies of pigment pattern formation -- 10 Evolution of Pigment Pattern Formation in Teleosts -- 11 Mechanisms of feather structural coloration and pattern formation in birds -- 12 Mechanism of color pattern formation in insects -- Part 3 Color changes -- 13 Physiological and Morphological Color Changes in Teleosts and in Reptiles -- 14 Color change in cephalopods -- 15 Physiological and biochemical mechanisms of insect color change towards understanding molecular links.

Description / Table of Contents: Chapter 1. Nanotechnology based bacterial immunotherapy -- Chapter 2. Immunomodulatory properties of nutraceuticals and functional foods -- Chapter 3. Immunoregulatory bioactive phytoconstituents- recent trends and future challenges -- Chapter 4. Plant derived immunomodulators and immune system -- Chapter 5. Polyphenols and its effect on immune system -- Chapter 6. Mineral nutraceuticals and immunity enhancement -- Chapter 7. Nutraceuticals as disease preventive food and immunity boosters -- Chapter 8. Current and Future prospects of flavonoids for human Immune system -- Chapter 9. Resveratrol and immunomodulation -- Chapter 10. Immunomodulation impact of curcumin and its derivative as a natural ingredient -- Chapter 11. Colchicine and andrographolide as natural immunomodulators -- Chapter 12. Immune booster property of epigallocatechin-3-gallate and catechin -- Chapter 13. Recent advances of nutraceutical and functional foods in immune health -- Chapter 14.Therapeutic effects of Withania somnifera-an overview with special focus on Alzheimer’s disease and infertility among youth.

Description / Table of Contents: Chapter 1. Origin and Evolution of Rice as Domesticated Food Crop -- Chapter 2. Major constraints for global rice production: Changing climate, abiotic and biotic stresses -- Chapter 3. Germplasm and genetic diversity studies in rice for stress response and quality traits -- Chapter 4. Potentiality of wild rice in quality improvement of cultivated rice varieties -- Chapter 5. Improvement of Rice Quality: The New Revolution -- Chapter 6. Sequencing the Rice Genome: Gateway to Agricultural Development -- Chapter 7. Genomics approaches to understand varietal differences in rice species and genotypes with respect to stress response and quality traits -- Chapter 8. Selection and hybridization techniques for stress management and quality improvement in rice -- Chapter 9. Transformation techniques and molecular analysis of transgenic rice -- Chapter 10. New approaches for improving salt stress tolerance in rice -- Chapter 11. Genomics and biotechnological approaches in generating salinity and drought tolerance in rice -- Chapter 12. An integrated approach for drought tolerance improvement in rice -- Chapter 13. Genomics and genetic engineering to develop metal/metalloid stress tolerant rice -- Chapter 14. Potential biotechnological strategies to improve quality and productivity of rice under arsenic stress -- Chapter 15. Genetic engineering: A powerful tool to abrogate the effect of metal/metalloid toxicity in rice -- Chapter 16. Genomics and genetic engineering of rice for tolerance to ozone and anoxia -- Chapter 17. Physiological and genetic basis of submergence tolerance in rice -- Chapter 18. Transgenic rice for survival in nutrient-deficient soil -- Chapter 19. Genetic engineering in rice to survive in nutrient-deficient soil -- Chapter 20. Developing C4 rice for higher photosynthetic efficiency and environmental stress tolerance -- Chapter 21. Rice tolerance to high light intensity and UV radiation: Genomics, breeding and genetic engineering -- Chapter 22. Improving rice tolerance to low and high temperature stress through biotechnological approaches -- Chapter 23. Biotechnological approaches to develop rice tolerance to low and high temperature stress -- Chapter 24. Influence of night temperature on rice yield and quality -- Chapter 25. Rice tolerance to multiple abiotic stress: Genomics and genetic engineering -- Chapter 26. Targeting metabolic pathways for genetic engineering abiotic stress tolerance in rice -- Chapter 27. Targeting phytohormone levels for genetic engineering abiotic stress tolerance in rice -- Chapter 28. The effect of exposure to a combination of stressors on rice productivity and grain yields -- Chapter 29. Rice Grain Quality Traits: Neglected or Less Addressed? -- Chapter 30. Rice grain quality and abiotic stress: Genomics and biotechnological perspectives -- Chapter 31. Increasing rice grain yield under abiotic stresses: mutagenesis, genomics and transgenic approaches.-.

Description / Table of Contents: Ch 1: The seminiferous epithelial cycle of spermatogenesis: Role of non-receptor protein kinases -- Ch 2: Sertoli cells: immunology and spermatogenesis -- Ch 3: Innate immunity and spermatogenesis -- Ch 4: Cell apoptosis and spermatogenesis -- Ch 5: Transcriptional regulation of spermatogenesis -- Ch 6: Sertoli cell cytoskeleton and spermatogenesis -- Ch 7: Leydig cell and spermatogenesis -- Ch 8: Cross-talk of cell junctions to support spermatogenesis -- Ch 9: Coordination of F-actin- and MT-based cytoskeletons to support spermatogenesis -- Ch 10: Regulation of the blood-testis barrier by basement membrane laminin-α2 chain -- Ch 11: Regulation of spermatogenesis by collagens -- Ch 12: Androgen regulation of spermatogenesis -- Ch 13: Use of molecular modeling to study spermatogenesis -- Ch 14: Acrosome biogenesis during spermatogenesis -- Ch 15: Stem cells and spermatogenesis -- Ch 16: Advances in our understanding of spermatogenesis in humans -- Ch 17: Leydig cell function in aging men -- Ch 18: Regulation of human spermatogenesis.

Description / Table of Contents: Foreword - A brief history of Spermatology -- Part I: Overview -- Chapter 1: Overview of reproduction systems in aquatic animals -- Part II: Basic knowledge of male gametes in aquatic animals -- Chapter 2: Introduction to sperm motility of aquatic animals -- Chapter 3: Sperm activation and chemotaxis of invertebrates -- Chapter 4: Fish sperm activation -- Chapter 5: Sperm guidance in Teleosts -- Part III: Basic knowledge of female gametes and sperm-egg interaction in aquatic animals -- Chapter 6: Structure of mature oocytes -- Chapter 7: Oocyte maturation and fertilization in Mollusks and other Protostomes -- Chapter 8: Reproduction of the corals Acropora -- Chapter 9: Self- and nonself-recognition of gametes in Ascidians -- Chapter 10: Reproduction of Elasmobranchs -- Chapter 11: Fertilization in Amphibians -- Part IV: Behavior, ecology and reproductive strategies -- Chapter 12: Sperm motility and fertilization of sea urchins -- Chapter 13: Behavior and fertilization of Squids -- Part V: Biotechnology in aquatic species -- Chapter 14: Improvements on the reproductive control of the European eel -- Chapter 15: Sperm cryopreservation of aquatic species -- Chapter 16: Germ cells transplantation in Sturgeon -- Chapter 17: Germ cell transplantation in tuna.

Description / Table of Contents: Chapter 1. Literature review -- Chapter 2. Results of experimental studies of short peptides (cytogens) in ophthalmology -- Chapter 3. Results of the clinical study of short peptides (cytogens) in ophthalmology -- Conclusion.

Description / Table of Contents: The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies -- Genomics and the Immune Landscape of Osteosarcoma -- RECQ DNA Helicases and Osteosarcoma -- Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma -- Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma -- Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response -- Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: 2019 update -- The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets -- Autophagy in OS -- Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs -- Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment -- Comparative Immunology and Immunotherapy of Canine Osteosarcoma -- Index.

Description / Table of Contents: Autophagy and Alzheimer’s Disease -- Autophagy and Parkinson’s Disease -- Autophagy and Motor Neuron Diseases -- Autophagy and Prion Disease -- Autophagy and Lysosome Storage Disorders -- Autophagy and Mitochondrial Encephalomyopathies -- Autophagy and Ischemic Stroke -- Autophagy and Hemorrhagic Stroke -- Autophagy and Polyglutamine Disease -- Autophagy and Epilepsy -- Autophagy in Neurodevelopmental Disorders -- Autophagy and Pituitary Adenoma -- Autophagy in Schizophrenia -- Autophagy and Hypertension -- Autophagy and Myocardial Ischemia -- Autophagy and Heart Failure -- Autophagy, Myocarditis and Cardiomyopathy -- Autophagy, Hyperlipidemia and Atherosclerosis -- Application of Autophagy in Cardiovascular Diseases -- Autophagy and Tumorigenesis -- Autophagy and Tumour Stem Cells -- Autophagy and Tumour Metastasis -- Autophagy and Tumor Cell Death -- Autophagy and Tumour Chemotherapy -- Autophagy and Tumour Radiotherapy -- Autophagy and Inflammatory Diseases -- Autophagy and Immune-related Diseases -- Autophagy and Autoimmune Diseases -- Autophagy and Bacterial Infection -- Autophagy and Viral Infection -- Autophagy and Thyroid Disease -- Autophagy and Obesity and Diabetes -- Autophagy and Obesity-related Reproductive Dysfunction -- Autophagy and Acute Kidney Injury -- Autophagy and Glomerular Diseases -- Autophagy and Diabetic Nephropathy -- Autophagy and Liver Diseases -- Autophagy and Gastrointestinal Diseases -- Chronic Obstructive Pulmonary Disease and Autophagy -- Autophagy and Pulmonary Fibrosis -- Asthma and Autophagy -- Autophagy and Other respiratory diseases -- Autophagy and Leukemia -- Autophagy and Lymphoma -- Autophagy and Myeloma -- The Function and Mechanisms of Autophagy in Traumatic Brain Injury -- The Function and Mechanisms of Autophagy in Spinal Cord Injury -- The Function and Mechanisms of Autophagy in Trauma of Other Parts of the Body -- The Prospects of Therapeutic Potential and Drug Development Targeting Autophagy in Cancer -- Progress of Anti-aging Drugs Targeting Autophagy -- Drug Development and Treatment of Autophagy in Other Diseases -- Systems Biology Approaches in Autophagy Research -- Natural Product Regulates Autophagy in Cancer -- Regulation of Autophagy in Neurodegenerative Diseases by Natural Products -- Regulation of Autophagy in Cardiovascular Diseases by Natural Products.

Description / Table of Contents: Apelin Receptor Signaling During Mesoderm Development -- Epidermal stem cells in regenerative medicine -- The cellular and molecular patterns involved in the neural differentiation of adipose-derived stem cells -- Biomatrices for heart regeneration and cardiac tissue modelling in vitro -- Dentin-Pulp Tissue Regeneration Approaches in Dentistry: An Overview and Current Trends -- Stem Cell Culture under Simulated Microgravity -- Smart Polymeric Systems: A Biomedical Viewpoint -- Acute lung injury: Disease modelling and the therapeutic potential of stem cells -- COVID-19 and Mesenchymal Stem Cell Treatment; Mystery or Not -- PCDH19 pathogenic variants in males: Expanding the phenotypic spectrum.

Description / Table of Contents: Introduction -- The major processes in the biological world -- Enzymes, conformational changes, energy, and molecular motors -- The cells -- Genome -- Regulation of gene expression and protein activity -- DNA replication, its fidelity, mutations, and repair -- Transduction of signals -- Multicellular organisms and their development -- Biological defense I. Protection from foreign nucleic acids -- Biological defense II. The immune system of vertebrates -- Pathogens -- Cancer -- Index.

Description / Table of Contents: Chapter 1: Fibronectin Fibrillogenesis during Angiogenesis -- Chapter 2: Functional Interplay Between Fibronectin and Matricellular Proteins in the Control of Endothelial Tubulogenesis -- Chapter 3: Endothelial Cell-Matrix Interactions in Angiogenesis and Vessel Homeostasis: A Focus on Laminins and Their Integrin Receptors -- Chapter 4: Collagens and collagen-degrading enzymes in the regulation of angiogenesis -- Chapter 5: Kruppel-like factor 2 and matrix metalloproteinases in the context of vasculature -- Chapter 6: Extracellular Matrix-Remodeling Enzymes as Targets for Natural Antiangiogenic Compounds -- Chapter 7: Cell - extracellular matrix adhesions in vascular endothelium -- Chapter 8: Hypoxia: a potent regulator of angiogenesis through extracellular matrix remodeling -- Chapter 9: Leading roles of heparan sulfate in angiogenesis and cancer -- Chapter 10: The role of pericytes in tumor angiogenesis -- Chapter 11: Lymphatic Mechanoregulation in Development and Disease.

Description / Table of Contents: Oxidative stress and toxicity in reproductive biology and medicine: Historical perspectives and future horizons in male fertility -- Reactive Oxygen Species in the Reproductive System: Sources and Physiological Roles -- Pathological Roles of Reactive Oxygen Species in Male Reproduction -- Molecular Interactions Associated with Oxidative Stress Mediated Male Infertility: Sperm and Seminal Plasma Proteomics -- Unraveling the Molecular Impact of Sperm DNA Damage on Human Reproduction -- Role of Infection and Leukocytes in Male Infertility -- Bacteriospermia and Male Infertility: Role of Oxidative Stress -- Oxidant-Sensitive Inflammatory Pathways and Male Reproductive Functions -- Oxidative Stress and Idiopathic Male Infertility -- Oxidative Stress and Varicocele-Associated Male Infertility -- Oxidative Stress in Men with Obesity, Metabolic Syndrome and Type 2 Diabetes Mellitus: Mechanisms and Management of Reproductive Dysfunction -- Metabolic dysregulation and sperm motility in male infertility -- Tale of viruses in male infertility -- Pathogenesis of Viral Infections and Male Reproductive Health: An Evidence-Based Study -- Sperm redox system equilibrium: Implications for fertilization and male fertility.

Description / Table of Contents: A historical and evolutionary view of tight junctions -- Tricellular tight junctions -- Mechanosensitivity of tight junctions -- Intracellular traffic and non-canonical roles of ZO-2 protein -- Impact of claudin-2 and occludin expression in inflammation disorders -- Tight junctions in the inflamed gut -- Intestinal barrier disruption by enteropathogenic Escherichia coli -- Tight junction barrier function regulation by microbiota -- Claudin-7 participation in cell-substrate adhesion, cell migration, salt balance in the renal collecting duct and gut cell renewal and differentiation -- Regulation of the alveolar epithelial barrier by claudin-5 -- Regulation of the blood-retinal barrier by occludin phosphorylation, norrin and sonic hedgehog signaling -- Transmigration of metastatic cells through the blood-brain barrier -- Endocytosis of tight junction proteins -- Regulated degradation of claudins. .

Description / Table of Contents: Preface -- Tissue-specific cell signaling: introduction -- Beyond the brain signaling -- Cell signaling within pituitary, the master gland of the endocrine system -- Cell signaling within endocrine glands: thyroid, parathyroids and adrenal glands -- Signaling pathways governing activation of innate immune cells -- Cell activation and signaling in lymphocytes -- Signaling pathways involved in kidney and urinary tract physiology and pathology -- More than androgens: hormonal and paracrine signaling in prostate development and homeostasis -- Testicular signaling: team work in sperm production -- Sperm signaling specificity: from sperm maturation until oocyte recognition -- Hormone signaling pathways in the postnatal mammary gland -- Oogenesis signaling: from development to environmental plasticity and aging -- Key signaling pathways in the cardiovascular system -- Growth factor signaling in the maintenance of adult lung homeostasis -- The signaling pathways involved in the regulation of skeletal muscle plasticity -- Adipocyte-specific signaling.

Description / Table of Contents: Chapter 1. Magnetic Field Parameters and Biological Sample Differences that Lead to Differential Bioeffects -- Chapter 2. Static Magnetic Field Direction-induced Differential Biological Effects -- Chapter 3. Magnetic Properties of Biological Samples -- Chapter 4. Molecular Mechanisms for Electromagnetic Field Biosensing -- Chapter 5. Controlling Cell Membrane Potential with Static Non-uniform Magnetic Fields -- Chapter 6. Impact of Static Magnetic Fields on Cells -- Chapter 7. Impact of Static Magnetic Fields on Microorganisms, Plants and Animals -- Chapter 8. Static Magnetic Fields on Human Bodies -- Chapter 9. Potential Applications of Static Magnetic Fields in Cancer Treatment -- Chapter 10. Effects of Static Magnetic Fields on Diabetes and Its Complications -- Chapter 11. Impacts of Static Magnetic Field on Bone Health -- Chapter 12. Effects of Static Magnetic Fields on the Immune System -- Chapter 13. Biological Effects of Static Magnetic Fields on the Nervous System -- Chapter 14. The Biological Effects of Long-term Static Magnetic Field Exposure -- Chapter 15. Prospects, Pitfalls, and Opportunities for Human Static Magnetic Field Therapy.

Description / Table of Contents: Introduction -- Myosin Structure -- Cargo Binding by Unconventional Myosins -- Cryo-EM of Actin-Myosin Structures -- Small Molecule Effectors of Myosin Function -- Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction -- High-Speed Atomic Force Microscopy to Study Myosin Motility -- How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches -- How Actin Tracks Affect Myosin Motors -- Myosins in the Nucleus -- Myosins in Cytokinesis -- Myosins and Disease -- Myosins and Hearing -- The Actomyosin Systems in Apicomplexa -- Approaches to Identify and Characterise MYO6-Cargo Interactions -- Class IX Myosins: Motorized RhoGAP Signaling Molecules -- Myosin X -- Myosin XVI -- Myosin XVIII -- Myosin XIX.

Description / Table of Contents: Chapter 1. Structure, Dynamics and Function of the 26S Proteasome -- Chapter 2. Factor VIII and Factor V Membrane Bound Complexes -- Chapter 3. An Overview of DPS: Dual Acting Nanovehicles in Prokaryotes with DNA Binding and Ferroxidation Properties -- Chapter 4. Structure and Function of the Separase-Securin Complex -- Chapter 5. The DNA Replication Machine: Structure and Dynamic Function -- Chapter 6. Recent Progress in Structural Studies on the GT-C Superfamily of Protein Glycosyltransferases -- Chapter 7. How Structures of Complement Complexes Guide Therapeutic Design -- Chapter 8. Architecture and Assembly of the Bacterial Flagellar Motor Complex -- Chapter 9. Cellulosomes: Highly Efficient Cellulolytic Complexes -- Chapter 10. Leucine Dehydrogenase: Structure and Thermostability -- Chapter 11. Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3 -- Chapter 12. The SF3b Complex Is an Integral Component of the Spliceosome and Targeted by Natural Product-based Inhibitors -- Chapter 13. Interaction Networks of Ribosomal Expansion Segments in Kinetoplastids -- Chapter 14. Hepatitis B Core Protein Capsids -- Chapter 15. Fibrinogen and Fibrin -- Chapter 16. Structural Organization and Protein-protein Interactions in Human Adenovirus Capsid -- Chapter 17. A Structural Perspective on Gene Repression by Polycomb Repressive Complex 2 -- Chapter 18. Assembly and Function of the Anthrax Toxin Protein Translocation Complex.

Description / Table of Contents: Chapter 1. Oxidative stress and oral diseases -- Chapter 2. Role of Oxidative stress in Chronic Liver Diseases -- Chapter 3. In-vitro and In-vivo Antioxidant activity of nanoparticles -- Chapter 4. Oxidative stress in neurology and neurodegenerative processes -- Chapter 5. The role of oxidative stress in respiratory diseases -- Chapter 6. Role of Synbiotics in alleviating oxidative stress in colorectal cancer -- Chapter 7. Oxidative Stress and Immunological Complexities in Multi-Drug Resistant Tuberculosis -- Chapter 8. Infection-induced Oxidative Stress in Chronic Respiratory Diseases -- Chapter 9. Oxidative stress in neuropsychiatric and neurodegenerative diseases -- Chapter 10. Oxidative stress monitoring in in vitro and in vivo models -- Chapter 11. Effects of Yoga on Aging.

Description / Table of Contents: Part I. Cancer -- Ubiquitin-Regulated Cell Proliferation and Cancer -- Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer -- The Proteasome System in Health and Disease -- Proteostasis Dysregulation in Pancreatic Cancer -- Divergent Modulation of Proteostasis in Prostate Cancer -- Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma -- Part II. Neurodegeneration -- Altered Proteostasis in Neurodegenerative Tauopathies -- The Ubiquitin System in Alzheimer’s Disease -- The Interplay Between Proteostasis Systems and Parkinson’s Disease -- Machado–Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides -- Part III. Infection, Inflammation and Developmental Disorders -- SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends -- The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication -- By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System -- TRIM E3 Ubiquitin Ligases in Rare Genetic Disorders -- Part IV. Diet -- We Are What We Eat: Ubiquitin–Proteasome System (UPS) Modulation Through Dietary Products.

Description / Table of Contents: Chapter 1. Molecular mechanisms of Nrf2 in inflammation: Interactions between Nrf2 and inflammatory mediators -- Chapter 2. Nrf2 in immune responses during inflammation -- Chapter 3. Nrf2 and Nrf2-interacting network in respiratory inflammation and diseases -- Chapter 4. Nrf2 in the regulation of endothelial cell homeostasis during inflammation -- Chapter 5. The roles of Nrf2 in cardiovascular system and atherosclerosis -- Chapter 6. Nrf2 and inflammation-triggered carcinogenesis -- Chapter 7. Role of Nrf2 in oxidative and inflammatory processes in obesity and metabolic diseases -- Chapter 8. Modulators of Nrf2 Activation during Inflammation.

Description / Table of Contents: 1 Introduction to High Altitude and Hypoxia -- 2 High altitude sickness: environmental stressor and altered physiological response -- 3 High-Altitude Related Diseases: Milder Effects, HACE, HAPE, and Effect on Various Organ Systems -- 4 High altitude-induced Oxidative stress, Rheumatoid Arthritis and proteomic alteration -- 5 Oxidative Stress, ROS generation and Associated Molecular Alterations in High Altitude Hypoxia -- 6 Oxidative Stress, ROS generation and Associated Molecular Alterations in High Altitude Hypoxia -- 7 Current problems in diagnosis and treatment of high altitude sickness -- 8 Proteomics as a potential tool for biomarker discovery -- 9 Serum and Plasma Proteomics for High-Altitude Related Biomarker Discovery -- 10 Saliva Proteomics As Non-Invasive Application For Biomarker Studies -- 11 Role of genomics, proteomics and antioxidant interventions in preventing High Altitude Sickness -- 12 High Altitude Sickness And Antioxidant Interventions -- 13 Antioxidant therapy for high altitude sickness and Nano-medicine.

Description / Table of Contents: Chapter 1. Introductory Chapter: The Importance of Heat Shock Proteins in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparum -- Chapter 2. General Structural and Functional Features of Molecular Chaperones -- Chapter 3. The Role of Hsp70s in the Development and Pathogenicity of Plasmodium falciparum -- Chapter 4. Role of the J Domain Protein Family in the Survival and Pathogenesis of Plasmodium falciparum. Chapter 5. Role of Hsp90 in Plasmodium falciparum Malaria -- Chapter 6. The Role of Malaria Parasite Heat Shock Proteins in Protein Trafficking and Remodelling of Red Blood Cells -- Chapter 7. Role of Heat Shock Proteins in Immune Modulation in Malaria -- Chapter 8. Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Antimalarial Drug Discovery? -- Chapter 9. Heat Shock Proteins as Targets for Novel Antimalarial Drug Discovery -- Chapter 10 -- Heat Shock Proteins of Malaria: Highlights and Future Prospects.

Description / Table of Contents: Chapter 1. A Historical and Technological Background to Organs-on-a-Chip -- Chapter 2. Applications of microfluidics -- Chapter 3. Microfluidics based Organ-on-a-chip for cell biology studies -- Chapter 4. Microfluidics in Chemical biology -- Chapter 5. Role of microfluidics in drug delivery -- Chapter 6. Microfluidics in drug discovery -- Chapter 7. Microfludic based sensors -- Chapter 8. Background and Organs-on-a-Chip -- Chapter 9. Culture and co-culture of cells for multi organ on chip -- Chapter 10.Cells and organs on a chip in biomedical sciences -- Chapter 11. Futuristic aspects of organ on a chip -- Chapter 12. Development of Human on a chip -- Chapter 13. Multi-organ on a chip for personalized medicine -- Chapter 14. Development and application of Microfluids in organoid formation -- Chapter 15. Liver on a chip -- Chapter 16. Placenta on Chip: A Modern approach to probe feto-maternal interface -- Chapter 17. Microfluidic retina-on-chip -- Chapter 18. Heart on a chip -- Chapter 19. Kidney on a chip -- Chapter 20. Lungs on a chip -- Chapter 21. Brain on a chip -- Chapter 22. Skin on a chip -- Chapter 23. Organs-on-a-chip in preclinical studies -- Chapter 24. Application of organ on chip in blood brain barrier model -- Chapter 25. Multi organs on a chip in disease modeling -- Chapter 26. Prospects of Medical device on a chip -- Chapter 27. Lab on a chip for precision Medicine -- Chapter 28. Tumour-on-a-chip : Perfusion systems to model the extracellular breast tumour microenvironment:from tumour progression to metastasis formation -- Chapter 29. Building Human In Vitro 3D Models to Replace Animal Studies: During Drug Discovery Reearch: Scientific, Ethical and Regulatory Considerations.

Description / Table of Contents: Section 1: Introduction of Acellularization -- Section 2: Extra Cellular Matrix (ECM) as a Bioscaffold -- Section 3: Methods of Characterization of Acellularized Tissue -- Section 4: Methods of Sterilization of Acellularized Tissue -- Section 5: skin -- Chapter 1: Thin Skin -- Chapter 2: Thick Skin -- Section 6: Cartilage Tissue -- Chapter 1: Hyaline cartilage -- Chapter 2: Fibrocartilage -- Chapter 3: Elastic cartilage -- Section 7: Bone Tissue -- Section 8: Cardiovascular System -- Section 9: Digestive System I -- Chapter 1: Tongue -- Chapter 2: Esophagus -- Chapter 3: Stomach -- Chapter 4: Small Intestine -- Chapter 5: Large Intestine -- Section 10: Digestive System II -- Chapter 1: Liver -- Chapter 2: Pancreases -- Chapter 3: Gallbladder -- Section 11: Respiratory System -- Chapter 1: Trachea -- Chapter 2: Lung -- Section 12: Urinary System -- Chapter 1: Kidney -- Chapter 2: Bladder -- Section 13: Nerve System -- Chapter 1: Central Nerve System (CNS) -- Chapter 2: Peripheral Nerve System (PNS) -- Section 14: Female Reproductive System -- Chapter 1: Ovary -- Chapter 2: Uterus -- Chapter 3: Vagina -- Chapter 4: Cervix -- Section 15: Male Reproductive System -- Chapter 1: Prostate Gland -- Chapter 2: Testis.

Description / Table of Contents: Introduction -- Porosome: Cells Secretory Nanomachine -- Ubiquitin-Proteasome Machinery: Cells Garbage Disposal -- Chaperonin: Protein Folding Machinery in Cells -- ATP Synthase: Energy Generator of the Cell -- Ribosome: Cells Protein Synthetic Machinery -- Nuclear Pore: A Bidirectional Transport Machinery -- Myosin: Cellular Molecular Motor -- Assembly of Cellular Nanomachines. Index.

Description / Table of Contents: Introduction (MCG and FN) -- Updates on ATMP regulations from EU: experience with PRIME procedure and list of approved ATMP -- EU portal for clinical trials application -- European Pharmacopoeia texts on gene therapy medicinal products -- Updates on ATMP regulations from UK after Brexit and list of approved ATMP -- Updates on ATMP regulations from Switzerland and list of approved ATMP -- Updates on ATMP regulations from US FDA: experience with breakthrough/accelerated procedures and list of approved ATMP -- Updates on ATMP regulations from Canada and list of approved ATMP -- Updates on ATMP regulations from Brasil and list of approved ATMP -- Updates on ATMP regulations from Singapore and list of approved ATMP -- Updates on ATMP regulations from Japan: experience with new law and list of approved ATMP -- Updates on ATMP regulations from South Korea and list of approved ATMP -- Updates on ATMP regulations from Taiwan and list of approved ATMP -- Updates on ATMP regulations from Thailand and list of approved ATMP -- ATMP regulations in China and list of approved ATMP -- ATMP regulations in Australia and list of approved ATMP -- ATMP regulations in India and list of approved ATMP -- International harmonization programs. .

Description / Table of Contents: 1 Understanding the small world: The Microbes -- 2 Bacteria and their industrial importance -- 3 Industrial perspectives of fungi -- 4 Microbial fermentation: basic fundamentals and its dynamic prospect in various industrial applications -- 5 Fermenter Design -- 6 Strain improvement of microbes -- 7 Enzyme Kinetics: a plethora of information -- 8 Asparaginase: Production, harvest, recovery and potential industrial application -- 9 Laccases: production, harvest, recovery, and potential industrial application -- 10 Pectinases: Production, harvest, recovery, and potential industrial application -- 11 Production of malt-based beverages -- 12 Biotransformation of industrially important steroid drug precursors -- 13 Value addition to chemical compounds through biotransformation -- 14 Fermentation Strategies for Organic Acid Production -- 15 Biological Production of Succinic Acid: State of the Art and Future Perspectives -- 16 Biomass, Bioenergy, and Biofuels -- 17 Biomethanation: Advancements for Upgrading Biomethane in Biogas Technologies -- 18 Microbial Bioelectricity Generation & Product Electrosynthesis -- 19 Microbial assisted systems for lignin-based product generation -- 20 Bioremediation Technology : A cumulative study of Microbial bioremediation of heavy metals, aromatic hydrocarbons, acrylamide and polyacrylamide -- 21 Microbes and their application in the food and agriculture industry -- 22 Microbes in resource and nutrient recovery via wastewater treatment -- 23 Potential of CRISPR/Cas9-based genome editing in the fields of industrial biotechnology-strategies, challenges, and applications -- 24 Animal cell culture: Basics and applications.

Description / Table of Contents: Part I. Search for novel tumor epitopes related to carbohydrates -- Chapter 1.1. The ganglioside structures: chemistry and biochemistry -- Chapter 1.2. Fucosylated proteins as cancer biomarkers -- Part II. Assembly of glycoconjugates -- Chapter 2.1. Siglec-7 and synthetic sialylpolymer -- Chapter 2.2. Role of Sialyl-Tn antigen in Cancer Metastasis -- Chapter 2.3. Insights into the Role of Chondroitin Sulfate in Cancer -- Part III. Signaling pathways modulated by glycosylation -- Chapter 3.1. Significance of FUT8in pancreatic cancer and others -- Chapter 3.2. Effects of Bullfrog sialic acid-binding lectin in cancer cells -- Part IV. Interaction between carbohydrate and carbohydrate-recognizing molecules -- Chapter 4.1. Opposite functions of mono- and disialylated glycosphingolipids on the membrane of cancer cells -- Chapter 4.2. Tumor progression through interaction of mucins with lectins and subsequent signal transduction -- Part V. Clinical trials targeting glycosignals -- Chapter 5.1. Immunotherapy of Neuroblastoma Targeting GD2 and Beyond.

Description / Table of Contents: Monkeypox and Sexually Transmitted Diseases -- Clinical Manifestations of Monkeypox -- Laboratory Diagnosis for Monkeypox: Clinical Practice and Important Points to Be Recognized -- Regulatory Mechanisms of Muscle Mass: The Critical Role of Resistance Training in Children and Adolescent -- HSF1 and Its Role in Huntington's Disease Pathology -- Leveraging Tissue Engineering for Skin Cancer Models -- Application of Drug Repurposing-Based Precision Medicine Platform for Leukaemia Patient Treatment -- Stem Cell-Derived Extracellular Vesicles as a Potential Therapeutic Tool for Eye Diseases: From Benchtop to Bedside -- Cannabinoids as Prospective Anti-Cancer Drugs: Mechanism of Action in Healthy and Cancer Cells -- Direct Reprogramming of Somatic Cells into Induced β-Cells: An Overview.

Description / Table of Contents: 1. It comes to us all -- 2. A rich bag of goodies: The human body as a source of nutrients -- 3. Our life-long microbial companions: Who are they, and what do they get up to when we're alive? -- 4. Not a pretty picture: Our appearance after death -- 5. The great betrayal: Our own cells and our symbionts turn against us -- 6. From the micro to the macro: Now the big guys move in -- 7. And what about the rest of the big, wide world?: Corpse decomposition and the environment.

Description / Table of Contents: Chapter 1: Introduction to Exocrinology -- Chapter 2: Exocrine Glands of the Integument -- Chapter 3: Exocrine Glands of the Respiratory Glands -- Chapter 4: Exocrine Glands of the Alimentary Tract System Section Part I -- Chapter 5: Exocrine Glands of the Alimentary Tract System Section Part II -- Chapter 6: Exocrine Glands of the Alimentary Tract System Section III -- Chapter 7: Exocrine Glands of the Reproductive System -- Chapter 8: Exocrine Glands of the Urinary system -- Chapter 9: Exocrine Glands of the Sensory Organs.

Description / Table of Contents: 1-Basic Idea About Nucleic Acids For Non-Experts -- 2-General Steps During Isolation Of DNA And RNA -- 3-Phenol-Chloroform DNA Isolation Method -- 4-RNA Isolation By The Guanidinium-Acid-Phenol Method -- 5-Spin Column-Based Isolation Of Nucleic Acid -- 6-Isolation Of Plasmid DNA By Alkaline Lysis -- 7-DNA Isolation By Hydrophilic Ionic Liquid Treatment -- 8-Lithium Chloride Based Isolation Of DNA And RNA -- 9-Isolation Of Bacteriophage DNA By Peg Method -- 10-DNA Isolation By Chelex Method -- 11-DNA Isolation By Lysozyme And Proteinase K -- 12-Salting-Out Method For Blood Samples -- 13-CTAB Or SDA Based Isolation Of Plant’s DNA -- 14-DNA Extraction By Spooling Method -- 15-Magnetic Bead-Based Nucleic Acid Isolation -- 16-Density Gradient-Based Nucleic Acid Isolation -- 17-DNA Extraction From Agarose Gel Though Paper-Strips -- 18-Transformation Or Genetic Modification Of Cells/Organisms -- 19-Gene Cloning And Vectors -- 20-Polymerase Chain Reaction (PCR) -- 21-Southern And Northern Blotting -- 22-Genome Mapping -- 23-Applications Of DNA Sequencing Technologies For Current Research.

Description / Table of Contents: Part 1: Functions of Macropinocytosis -- Chapter 1: Functional Diversity of Macropinocytosis -- Chapter 2: Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways -- Chapter 3: The amoebal model for micropinocytosis -- Chapter 4: Extracellular ATP and macropinocytosis -- Chapter 5: Macropinocytosis and Cell Migration: Don't drink an drive -- Chapter 6: Macropinocytosis in phagocyte function and immunity -- Part 2: Signaling Mechanisms Driving Macropinocytosis -- Chapter 7: Roles of 3' Phosphoinositides in Macropinocytosis -- Chapter 8: Signaling pathways that regulate macropinocytosis in mammalian cells -- Chapter 9: Wnt, GSK3 and Macropinocytosis -- Chapter 10: Kras addiction promotes cancer cell adapation in harsh microenvironment through micropinocytosis -- Chapter 11: Kras-independent macropinocytosis in pancreatic cancer.

Description / Table of Contents: Male infertility: a complete guide to lifestyle and environmental factors -- Use of folic acid in the treatment of oxidative-stress associated male infertility: a myth or reality? -- Methylglyoxal induced mitochondrial perturbation and neuronal toxicity in Alzheimer disease -- Free radicals-mediated oxidative damage in memory loss: Are antioxidant therapies useful? -- ROS-induced neural toxicity in Parkinson's Disease -- Cyclin-dependent Kinase in oxidative stress and development of cancer -- Radiation induced free radical formation lead to head and neck cancer -- Pathophysiology of radiations: Radiofrequency electromagnetic radiation oxidative stress and carcinogenesis -- Heavy metal contamination induced oxidative tress lead to neurodegenerative diseases -- Networking of nanoparticles toxicity in environment and possible role of ROS in disease mechanism -- Free radicals and microbes in nature -- Relevance of ROS and NOS in Leishmaniasis: A recent update -- Alcohol-induced neuronal toxicity in Alzheimer disease.

Description / Table of Contents: Part I Anatomy, Physiology and Pharmacology of Macrophages -- Introduction to Anatomy and Physiology of Macrophages from Drug Delivery Perspective -- Introduction to Pharmacology of Macrophages from Drug Delivery Perspective -- Mechanisms and Ways of Macrophage Delivery -- Macrophage Associated Disorders: Pathophysiology, Treatment Challenges and Possible Solutions -- Understanding Macrophage Associated Diseases and Applications of Nano Drug Delivery Systems -- Part II Polymeric Nanoparticles for Macrophage Targeting -- Targeting of Macrophages: Basic and therapeutic Role of Polymeric Nanoparticles -- Polymeric Nanoparticles Based Drug and Gene Delivery to Macrophages -- Surface Modification of Nanoparticles for Macrophage Targeting -- Part III Lipid Nanoparticles for Macrophage Targeting -- Liposomes as Delivery System for Macrophage Targeting -- Solid Lipid Nanoparticles Based Drug and Gene Delivery to Macrophages -- In vivo Fate of Colloidal Carriers Undergoing Macrophage Targeting -- Nanoparticle-based Theranostics for Macrophage-associated Diseases -- Part IV Targeting Macrophages for Treatment of Various Diseases -- Tumor Associated Macrophages as Therapeutic Target for Drug/immune Therapy of Cancer -- Macrophage Targeting for Therapy of Autoimmune Diseases -- Macrophage Targeting for Therapy of Cardiovascular Diseases (CVD) -- Macrophage targeting for therapy of intracellular infections -- Targeting Drugs and Nucleic Acids to Macrophages for Therapy of Inflammatory Diseases -- Macrophage Targeted Chemotherapy for Tuberculosis and other Respiratory Disease. -- Part V Specific Formulations and Clinical Trials on Macrophage Targeted Delivery -- Nano- and Microparticles Based Dry Powder Inhalers for Pulmonary Macrophage Drug Delivery -- Recent Trends in Clinical Studies on Macrophage Targeted Delivery -- Future Directions and Challenges in Macrophage Targeting. .

Description / Table of Contents: Feto-Placental Unit: from development to function -- Role of hormones during gestation and early development: pathways involved in developmental programming -- Physiological and pathophysiological role of large-conductance calcium-activated potassium channels (BKCa) in HUVECs and placenta -- Metabolic interaction between Folate, Vitamin B12 and Polyunsaturated Fatty Acids in pregnancy -- Evidence of nitric oxide impairment during hypertensive pregnancies -- Pathophysiology of preeclampsia and L-Arginine/L-citrulline supplementation as a potential strategy to improve birth outcomes -- Maternal and fetal expression of ATP-binding cassette and Solute Carrier transporters involved in the brain disposition of drugs -- Development of the placenta and brain are affected by selective serotonin reuptake inhibitors exposure during critical periods -- The endocannabinoid system in placenta and respiratory central nervous system development: effects of prenatal exposure to cannabinoids -- Impact of prenatal nicotine exposure on placental function and respiratory neural network development -- Language impairment in children of mothers with gestational diabetes, preeclampsia, and preterm delivery: current hypothesis and potential underlying mechanisms -- COVID-19 on pregnancy outcomes, mental health and placenta: focus in Latin America -- The placental function beyond pregnancy: Insights from Latin America.

Description / Table of Contents: Endothelialization and Inflammatory Reactions After Intracardiac Device Implantation -- Articular Cartilage Regeneration in Veterinary Medicine -- Adult Stem Cell Therapy as Regenerative Medicine for End-Stage Liver Disease -- An Affordable Approach of Mesenchymal Stem Cell Therapy in Treating Perianal Fistula Treatment -- Virus, Exosome, and MicroRNA: New Insights into Autophagy -- Epitranscriptomics Changes the Play: m6A RNA Modifications in Apoptosis -- The Fingerprints of Biomedical Science in Internal Medicine -- Mesenchymal Stem Cell-Derived Extracellular Vesicles: Progress and Remaining Hurdles in Developing Regulatory Compliant Quality Control Assays -- Pharmacological Effects of Caffeic Acid and Its Derivatives in Cancer: New Targeted Compounds for the Mitochondria -- Systematically Assessing Natural Compounds' Wound Healing Potential with Spheroid and Scratch Assays.

Description / Table of Contents: Part 1: Soluble Protein Complexes -- Chapter 1: Fatty Acid Synthase: Structure, Function, and Regulation -- Chapter 2: ATP-binding cassette transporters: Snap-on complexes? -- Chapter 3: The Fork Protection Complex: A regulatory hub at the head of the replisome -- Chapter 4: Ferritin-like Proteins: A Conserved Core for a Myriad of Enzyme Complexes -- Chapter 5: Still no rest for the reductases: Ribonucleotide reductase (RNR) Structure and Function — an update -- Chapter 6: Structure and Dynamics of the Human Multi-tRNA Synthetase Complex -- Chapter 7: On the regulation of mitosis by the kinetochore, a macromolecular complex and organising hub of eukaryotic organisms -- Part 2: Membrane Protein Complexes -- Chapter 8: The conformational dynamics of heterotrimeric G proteins during GPCR-mediated activation -- Chapter 9: Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome -- Chapter 10 : Structure, Function, and Regulation of the Kainate Receptor -- Chapter 11: Structure, function and variations of the photosystem I-antenna supercomplex from different photosynthetic organisms -- Chapter 12: Structure and Function of Mycobacterial Arabinofuranosyltransferases -- Part 3: Fibrous Protein Complexes -- Chapter 13: Structure and assembly of the bacterial flagellum -- Chapter 14: Actomyosin Complex -- Chapter 15: Structure of motile cilia -- Chapter 16: Segment-Long-Spacing (SLS) and the Polymorphic Structures of Fibrillar Collagen -- Part 4: Virus Protein Complexes -- Chapter 17: Viral Capsid and Polymerase in Reoviridae.

Description / Table of Contents: Brain Tissue Oxygen and BOLD fMRI Under Different Levels Of Neuronal Activity -- Cerebral Microcirculation and Oxygenation Modulation by Transcranial Alternating Current Stimulation in Awake and Anesthetized Mice -- The Effect of Hypercapnia on Cortical Metabolic Rate and Mitochondrial Redox Status -- Relationship Between Left-Right Dominancy of Prefrontal Cortex Activity and Heart Rate During Rest and Task Periods: An fNIRS Study -- Relationship Between Cognitive Function, Oral Conditions and Systemic Metabolic Function in the Elderly -- Pro-survival Phenotype of HIF-1α: Neuroprotection through Inflammatory Mechanisms -- Infradian Rhythms in Cerebrovascular Oxygenation and Blood Volume in Humans at Rest: A 5-year Study -- Mechanisms of Photostimulation of Brain’s Waste Disposal System: the Role of Singlet Oxygen -- Changes of Arterial and Venous Cerebral Blood Flow Correlation in Moderate-to-Severe Traumatic Brain Injury: A CT Perfusion Study -- Cerebral Net Water Uptake in Posttraumatic Cerebral Ischemia -- Brainstem Damage Underlies Changes in Hypoxic Ventilatory Response following Cardiac Arrest and Resuscitation in Rats -- Differences Between Good, Moderate and Poor Performers of a Verbal Fluency Task under Blue Light Exposure: An SPA-fNIRS Study -- Sex-specific and Dose-dependent Effects of Drag-Reducing Polymers on Microcirculation and Tissue Oxygenation in Rats after Traumatic Brain Injury -- Accuracy of Tissue Oxygen Saturation Measurements of a Textile-based NIRS Sensor -- Understanding the Role of Caveolae in Oxygen Buffering: The Effect of Membrane Curvature -- The Significance of Lipids for the Absorption and Release of Oxygen in Biological Organisms -- How Skin Color Depends on Tissue Oxygenation -- Tissue Concentration Analysis of Sulfur, Calcium and Oxygen in novel Skin Primo Nodes After Acupuncture -- Primo Vessels Inside Lymphatic Vessels are Absent in an ALS Mouse Model -- The Impact of Heterogeneous Cell Density in Hypoxic Tumors Treated with Radiotherapy -- A Critical Analysis of Possible Mechanisms for the Oxygen Effect in Radiation Therapy with FLASH -- Hyperhydration of Cancers: A Characteristic Biophysical Trait Strongly Increasing O2, CO2, Glucose and Lactate Diffusivities, and Improving Thermophysical Properties of Solid Malignancies -- No Difference in Muscle Basal Oxygenation in a Bedridden Population pre and Post Rehabilitation -- Relationship between Muscle Deoxygenation and Cardiac Output in Subjects without Attenuation of Deoxygenation Hemoglobin Concentration near the end of Ramp Cycling Exercise: A Longitudinal Study -- Image Reconstruction Using Deep Learning for Near-Infrared Optical Tomography: Generalization Assessment -- Neonatal Brain Temperature Monitoring Based on Broadband Near-Infrared Spectroscopy -- Time Domain Near-Infrared Optical Tomography Utilizing Full Temporal Data: A Simulation Study -- BIAN: A Multilayer Microfluidic-Based Tissue-Mimicking Phantom for Near-Infrared Imaging -- Do Vascular and Extracellular Measurements Consistently Reflect Intracellular pO2? Observation of Tissue Oxygenation Changes using Remote Photoplesysmography with a Smartphone -- Neurovascular, Metabolic, and Glymphatic Dynamics of the Brain Measured with fNIRS -- Imaging Cerebral Blood Vessels Using Near-Infrared Optical Tomography: A Simulation Study -- Reduced Cerebrovascular Oxygenation in Individuals with Post-Acute COVID-19 Syndrome (PACS) (“Long COVID”) -- Insufficient Oxygen Supplementation During Cardiopulmonary Resuscitation Leads to Unfavorable Biological Response While Hyperoxygenation Contributes to Metabolic Compensation -- Block of the Angiotensin Pathways Affects Flow-Volume Spirometry in Patients With SARS-CoV-2 Infection -- A Prospective Observational Pilot Study on the Effects of the Activity-based Stress Release Program on the Mental State and Autonomic Nervous System in Psychiatric patients. .

Description / Table of Contents: Chapter 1. Biological methods -- Chapter 2. Liposomal based drug delivery system -- Chapter 3. Hydrogel-based drug delivery strategies -- Chapter 4. Monoclonal antibodies -- Chapter 5. Electroporation -- Chapter 6. Photoporation -- Chapter 7. Mechanoporation -- Chapter 8. Magnetoporation -- Chapter 9. Microinjection -- Chapter 10. Jet injection -- Chapter 11. Sonoporation -- Chapter 12. Device based drug delivery techniques – microfluidics Chapter 13. Nanoparticles drug delivery systems -- Chapter 14. BioMaterials -- Chapter 15. Implanted drug delivery systems -- Chapter 16. Transdermal drug delivery systems -- Chapter 17. Subcutaneous drug delivery systems -- Chapter 18. Nasopulmonary drug delivery systems -- Chapter 19. Mucosal drug delivery systems -- Chapter 20. Intrauterine drug delivery systems -- Chapter 21. Gastro retentive drug delivery systems -- Chapter 22. Endoscopic assisted drug delivery -- Chapter 23. Theranostics.

Description / Table of Contents: Molecular Mechanisms of SARS-CoV-2/COVID-19 Pathogenicity on the Central Nervous System: Bridging Experimental Probes to Clinical Evidence and Therapeutic Interventions -- The Probable Protective Effect of Photobiomodulation on the Inflammation of the Airway and Lung in COVID-19 Treatment: A Preclinical and Clinical Meta-Analysis -- Metabolomics Signatures of SARS-CoV-2 Infection -- Autophagic Mediators in Bone Marrow Niche Homeostasis -- Pluripotency Stemness and Cancer: More Questions than Answers -- In Vitro Culturing of Adult Stem Cells: The Importance of Serum and Atmospheric Oxygen -- Mouse Models of Asthma: Characteristics, Limitations and Future Perspectives on Clinical Translation -- From Cells to Organs: The Present and Future of Regenerative Medicine -- Tissue-Restricted Stem Cells as Starting Cell Source for Efficient Generation of Pluripotent Stem Cells: An Overview -- Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium.

Description / Table of Contents: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.

Description / Table of Contents: 1. Computational Tools for Functional Analysis of Circular RNAs -- 2. The Hidden Layer of RNA Variants -- 3. Functional Role of Non-Coding RNAs in Prostate Cancer: From Biomarker to Therapeutic Targets -- 4. The structure, function, and modification of non-coding RNAs in cardiovascular system,- 5. Contribution of RNA Species in Sexually Transmitted Infections -- 6. Hypoxia and Epithelial-to-Mesenchymal Transition (EMT) in Cancer: A Non-Coding RNA Perspective -- 6. A Study on the Role of piRNAs in Cancer Epigenetics -- 7. Modified Nucleosides as RNA Components. Structure, Biological Role and Drug Design -- 8. Multifaceted Functions of RNA m6A Modification in Modulating Regulated Cell Death -- 9. Incorporation of Pseudouridine into RNA for Biochemical and Biophysical Studies -- 10. Molecular Dynamics Simulations of Chemically Modified Ribonucleotides.

Description / Table of Contents: Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and Cancer Immunotherapy -- Chaperonin Hsp60 and Cancer Therapies -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Therapeutics -- Multifaceted Roles of Heat Shock Factor 1 (HSF1) in Cancer -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- Heat Shock Proteins in Atrial Fibrillation -- Threading Microarrays into Novel Applications -- Regulation of Kaposi’s Sarcoma-associated Herpesvirus Biology by Host Molecular Chaperones -- Role of Heat Shock Factors in Diseases and Immunity -- Heat Shock Proteins and Pain -- Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with diverse Cellular and Molecular Functions -- Roles of Heat Shock Proteins on Antigen Presentation -- Heat shock proteins mediate anastasis and plasticity of thermotolerant cells.

Description / Table of Contents: Prelims -- One-carbon metabolism and development of the conceptus during pregnancy: Lessons from studies with sheep and pigs -- Cell-specific expression of enzymes for serine biosynthesis and glutaminolysis in farm animals -- Amino acids in beef cattle nutrition and production (author to be identified) -- Amino acid nutrition and reproductive performance in ruminants -- Amino acids in the nutrition and production of sheep and goats -- Amino acids in swine nutrition and production -- Amino acid nutrition and metabolism in chickens -- Nutrition and functions of amino acids in fish -- Nutrition and functions of amino acids in aquatic crustaceans -- Amino acids in dog nutrition and health -- Amino acids in the nutrition, metabolism, and health of domestic cats -- Amino acid nutrition for optimum growth, development, reproduction, and health of zoo animals.

Description / Table of Contents: Chapter 1: Regulation of Gene Expression by Amino Acids in Animal Cells -- Chapter 2: Amino acids in cell signaling: regulation and function -- Chapter 3: Amino Acids in Endoplasmic Reticulum Stress and Redox Signaling -- Chapter 4: Amino Acids in Autophagy: Regulation and Function -- Chapter 5: Oxidation of Energy Substrates in Tissues of Fish: Metabolic Significance and Implications for Gene Expression and Carcinogenesis -- Chapter 6: Arginine, Agmatine and Polyamines: Key Regulators of Conceptus Development in Mammals -- Chapter 7: Interorgan Metabolism of Glutamate and Glutamine in Poultry -- Chapter 8: Interorgan Metabolism of Amino Acids in Health and Disease -- Chapter 9: Amino Acids and Their Metabolites for Improving Human Exercising Performance -- Chapter 10: Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans -- Chapter 11: Composition of Amino Acids in Foodstuffs for Humans and Animals -- Chapter 12: Dietary Intakes of Amino Acids and Other Nutrients by Adult Humans.

Description / Table of Contents: Antibody-Drug Conjugates Basic Concepts and Structures -- Relationship between target and specific action of antibody-drugs conjugates -- The internalization and therapeutic activity of antibody drug conjugate -- The internalization and intracellular trafficking of ADC -- Distribution and metabolism of antibody-drug conjugates -- Application of Antibody fragments in ADCs -- Novel Targeting Carriers in Antibody-drug Conjugates -- Site-specified Conjugating Technology and Application -- Determination of drug-to-antibody ratio of ADCs -- Pharmacokinetic study of antibody-drug conjugates.

Description / Table of Contents: Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis -- Construction of minimal genomes and synthetic cells -- Engineering reduced-genome strains of Pseudomonas putida for product valorization -- Genome-reduced Corynebacterium glutamicum fit for biotechnological applications -- Reduction of the Saccharomyces cerevisiae genome: challenges and perspectives -- The use of in silico genome-scale models for the rational design of minimal cells -- From minimal to minimized genomes: Functional design of microbial cell factories -- Resource allocation principles and minimal cell design.

Description / Table of Contents: Workflows and Components of Bioimage Analysis -- Measurements of Intensity Dynamics at the Periphery of the Nucleus -- 3D Quantitative Colocalisation Analysis -- The NEMO Dots Assembly: Single-Particle Tracking and Analysis -- Introduction to MATLAB: Image Analysis & Brownian Motion -- Resolving the process of Clathrin Mediated Endocytosis Using Correlative Light & Electron Microscopy (CLEM).

Description / Table of Contents: The phenomenon of life. Planet system of life -- Individual Life. Living bodies - holders of life -- The Emergence of Individual Life and the Life Phenomena -- Development -- Reproduction of living bodies and genomes -- Ways and Mechanisms of Survival -- Aging and Loss of Individuals -- The processes and mechanisms of living bodies. The nature of vitality -- Information and Management. Mechanisms of the Invisible World of the Genome -- Living Bodies - Phenotypic Framing of Genomes -- Duality of Life -- Immortality. Power of the Genome -- Conclusion. The Unified System of Life.

Description / Table of Contents: Preface -- Chapter 1: microRNAs in normal brain physiology -- Chapter 2: Ischemic stroke: An imperative need for effective therapy -- Chapter 3: MicroRNAs in ischemic stroke pathophysiology: Special emphasis on early molecular events -- Chapter 4: microRNA regulation of ischemic stroke inflammatory and immune response -- Chapter 5: Regulatory role of microRNAs in ischemic cell death -- Chapter 6: The emerging role of microRNAs in post-ischemic angiogenesis and neurogenesis -- Chapter 7: MicroRNAs as potential diagnostic, prognostic and therapeutic biomarkers in ischemic stroke -- Chapter 8: Interplay between microRNAs and other cerebrovascular diseases -- Chapter 9: New insights into the regulatory role of lncRNA, circRNA, piRNAs, and ceRNAs in ischemic stroke -- Chapter 10: Computational resources for microRNA research -- Chapter 11: MicroRNA-targeted therapeutics for ischemic stroke: Status, gaps and the way forward.

Description / Table of Contents: Part 1: RNA Damage and Repair in Prokaryotes -- Chapter 1: Endoribonucleases of the toxin-antitoxin systems induce abortive infection -- Chapter 2: The lifecycle of ribosomal RNA in bacteria -- Chapter 3: The Rtc RNA end healing and sealing system -- Part 2: RNA Damage and Repair in Eukaryotes -- Chapter 4: Oxidative and nitrative RNA modifications in plants -- Chapter 5: The role of ribonucleases in RNA damage, inactivation, and degradation -- Chapter 6: Cytoplasmic mRNA recapping: An unexpected form of RNA repair -- Part 3: RNA Damage in Human Diseases -- Chapter 7: Adenosine-to-Inosine RNA editing: a key RNA processing step rewriting transcriptome in normal physiology and diseases -- Chapter 8: RNA-mediated metabolic defects in microsatellite expansion diseases.

Description / Table of Contents: Shaping of the tumor microenvironment by Notch signaling -- Erythropoietin signaling in the microenvironment of tumors and healthy tissues -- Neuropilin – handyman and power broker in the tumor microenvironment -- Translational landscape of mTOR signaling in integrating cues between cancer and tumor microenvironment -- Toll-like receptors signaling in the tumor microenvironment -- Rho-ROCK signaling in normal physiology and as a key player in shaping the tumor microenvironment -- S1P signaling in the tumor microenvironment -- CD200-CD200R pathway in the regulation of tumor immune microenvironment and immunotherapy -- Index.

Description / Table of Contents: Neutrophils in the Tumor Microenvironment -- Basophils in Tumor Microenvironment and Surroundings -- Janus or Hydra: The many faces of T helper cells in the human tumour microenvironment -- Cytotoxic CD8+ lymphocytes in the tumor microenvironment -- Mucosal-associated invariant T cells in tumors of epithelial origin -- Fibrocytes in the Tumor Microenvironment -- Models for Monocytic Cells in the Tumor Microenvironment -- Myeloid-Derived Suppressor Cells in the Tumor Microenvironment -- Index.

Description / Table of Contents: Chapter 1. Spectrum of sex in a horn of the Japanese rhinoceros beetle -- Chapter 2. Sexual differentiation in dragonflies and damselflies -- Chapter 3. Dimorphic female-limited Batesian mimicry in two Papilio butterflies -- Chapter 4. Spectrum of sex chromosomes in mammals -- Chapter 5. The evolutionary aspects of the mammalian sex-determining gene SRY -- Chapter 6. Revisiting the role of steroid hormones in gonadal fate determination -- Chapter 7. Sex steroid regulation of male- and female-typical mating behaviors in teleost fish -- Chapter 8. Comparative Perspectives on the Function of Oxytocin in Fish and Mammals -- Chapter 9. Orchestration of the synthesis of sex hormones and their roles in establishing sex differences in mammals -- Chapter 10. The role of sex spectrum differences in reproductive strategies and the endocrine mechanisms underlying it -- Chapter 11. Symbiont-induced sexual and reproductive manipulation in insects -- Chapter 12. The mechanism for establishing the binary sex with environmental signals in the crustacean Daphnia magna -- Chapter 13. Starvation is a new component of sex reversal in medaka (Oryzias latipes)—significance of metabolism in sex regulation. .

Description / Table of Contents: Chapter 1. Mechanisms and biological roles of DNA methyltransferases and DNA methylation – from past achievements to future challenges -- Chapter 2.Bacterial DNA Methylation and Methylomes -- Chapter 3. ChapterDomain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases -- Chapter 4. Enzymology of Mammalian DNA Methyltransferases -- Chapter 5. Genetic Studies on Mammalian DNA Methyltransferase -- Chapter 6. Structure and Mechanism of Plant DNA Methyltransferases -- Chapter 7. DNA Methylation in Honey Bees and the Unresolved Questions in Insect Methylomics -- Chapter 8. N6-Methyladenine: A Conserved and Dynamic DNA Mark -- Chapter 9. Pathways of DNA Demethylation -- Chapter 10. Structure and Function of TET Enzymes -- Chapter 11.Proteins That Read DNA Methylation -- Chapter 12. Recent advances on DNA base flipping – a general mechanism for writing, reading, and erasing DNA modifications.-Chapter 13. The Role of DNA Methylation in Cancer -- Chapter 14. DNMTs and DNA damage -- Chapter 15. Role of DNMTs in brain -- Chapter 16. Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns.-Chapter 17. Inhibitors of DNA methylation -- Chapter 18. Rewriting DNA Methylation Signatures at Will: The Curable Genome Within Reach? -- Chapter 19. DNA Labeling Using DNA Methyltransferases.

Description / Table of Contents: Elastin in the Tumor Microenvironment -- Decorin in the tumor microenvironment -- Syndecan-1 in the tumor microenvironment -- Versican in the tumor microenvironment -- Chondroitin Sulphate Proteoglycans in the Tumour Microenvironment -- Lipoproteins and the Tumor Microenvironment -- The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility -- Thrombospondin in Tumor Microenvironment -- Tenascin-C function in glioma: immunomodulation and beyond -- Index.

Description / Table of Contents: Part 1: Visualizing and Controlling Molecules for Life -- Chapter 1. Photoacoustic Tomography: Deep Tissue Imaging by Ultrasonically Beating Optical Diffusion -- Chapter 2. Regulatory Mechanism of Neural Stem Cells Revealed by Optical Manipulation of Gene Expressions -- Chapter 3. Eavesdropping on Biological Processes with Multi-Dimensional Molecular Imaging -- Chapter 4. Apical microtubules define the function of epithelial cell sheets consisting of non-ciliated or multi-ciliated cells -- Chapter 5. Illuminating the brain -- Chapter 6. Optogenetic assemblies of cortical force-generating complexes during mitosis -- Chapter 7. In vivo Imaging Probes with Tunable Chemical Switches -- Chapter 8. Circuit-dependent striatal PKA and ERK signaling underlying action selection -- Chapter 9. Electrophysiology, Unplugged: New Chemical Tools to Image Voltage -- Chapter 10. Molecular dynamics revealed by single-molecule FRET measurement -- Chapter 11. Comprehensive approaches using luminescence to studies of cellular functions -- Part II: Imaging Disease Mechanisms -- Chapter 12. Make Chronic Pain Visible -- Chapter 13. Cortical plasticity after spinal cord injury using resting-state functional magnetic resonance imaging -- Chapter 14. Multimodal Label-free imaging to assess compositional and morphological changes in cells during immune activation -- Chapter 15. Investigating in vivo myocardial and coronary molecular pathophysiology in mice with X-ray radiation imaging approaches -- Chapter 16. Visualizing the Immune Response to Infections -- Chapter 17. Imaging Sleep and Wakefulness -- Chapter 18. Abnormal local translation in dendrites impairs cognitive functions in neuropsychiatric disorders -- Chapter 19. Imaging synapse formation and remodeling in vitro and in vivo -- Part III: Imaging-based Diagnosis and Therapy -- Chapter 20. How MRI makes the Brain Visible -- Chapter 21. Intravital multiphoton imaging revealing cellular dynamics in vivo -- Chapter 22. Theranostic Near Infrared Photoimmunotherapy for Cancer -- Chapter 23. Novel and integrated imaging on Chronic Fatigue -- Chapter 24. Novel fluorescent probes for rapid tumor imaging and fast glutathione dynamics -- Chapter 25. Coronary Heart Disease Diagnosis: Engineering Triumphs, Economic Barriers -- Chapter 26. Live imaging of the skin immune responses -- Chapter 27. Development of a horizontal CT and its application to musculoskeletal disease -- Chapter 28. The Future of Precision Health & Integrated Diagnostics -- Chapter 29. Imaging and therapy against hypoxic tumors with 64Cu-ATSM.

Description / Table of Contents: Involvement of Endothelial Nitric Oxide Synthase in Cerebral Microcirculation and Oxygenation in Traumatic Brain Injury -- Imaging cerebral energy metabolism in healthy infants -- Changes in cerebral oxygenation and systemic physiology during a verbal fluency task: Differences between men and women -- Brain Tissue Conductivity in Focal Cerebral Ischemia -- Physical stress Attenuates Cognitive inhibition: An fNIRS Examination -- Changes in Prefrontal Cortical Oxygenation During Tilt Table Orthostatic Hypotension in Subarachnoid Haemorrhage Patients -- Effects of different optical properties of head tissues on near-infrared spectroscopy Using Monte Carlo Simulations -- Frontal cerebral oxygenation in humans at rest: A mirror symmetry in the correlation with cardiorespiratory activity -- Photomodulation of lymphatic delivery of bevacizumab to the brain: the role of singlet oxygen -- NIRS-based study of local cerebral oxygenation during transcranial direct current stimulation in patients with mild traumatic brain injury -- Postnatal Exposure to Brief Hypoxia Alters Brain VEGF Expression and Capillary Density in Adult Mice -- Impaired Cognitive Performance in Mice Exposed to Prolonged Hyperoxia -- Chronic Ketosis Modulates HIF1α-Mediated Inflammatory Response in Rat Brain -- Motor Imagery and Frontal Head Oxygenation: An fNIRS Study -- Non-invasive detection of persistent cortical hypoxia in Multiple Sclerosis using frequency domain near-infrared spectroscopy (fdNIRS) -- Evaluation of intraoperative end-tidal Carbon dioxide change relates to length hospitalization in peridiaphragmatic surgery: a pilot study -- Pulmonary Embolism in COVID-19 patients is not related to a worsening in tissue oxygenation -- Cardiovascular risk score and gas exchange in COVID-19 patients: no correlation -- Heme Oxygenase 1/ High Mobility Group Box 1 pathway may have a possible role in Covid-19 ARDS (Acute respiratory distress syndrome): a pilot histological study -- Silent Hypoxemia in COVID-19 pneumonia -- Low Flow and Microvascular Shunts: A Final Common Pathway to Cerebrovascular Disease: A Working Hypothesis -- A case of intracranial vertebral artery stenosis treated with percutaneous transluminal angioplasty and stenting guided by brain oximetry -- Assessment of Optimal Arterial Pressure with Near-Infrared Spectroscopy in Traumatic Brain Injury Patients -- Effects of exercise-diet therapy on cognitive function in healthy elderly people evaluated by deep learning based on basic blood test data -- NIRS studies show reduced interhemispheric functional connectivity in individuals with Multiple Sclerosis that exhibit cortical hypoxia -- Eye Tracking Parameters Correlate With the Level of Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Preliminary Study -- Critical closing pressure of cerebral circulation at concomitant moderate-to-severe traumatic brain injury -- Hybrid convolutional neural network (hCNN) for image reconstruction in near-infrared optical tomography -- Cross-frequency coupling between brain and body biosignals: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Machine learning distinguishes familiar from unfamiliar pairs of subjects performing an eye contact task: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Assessing Neurovascular Coupling Using Wavelet Coherence in Neonates With Asphyxia -- Basic examination of hemoglobin phase of oxygenation and deoxygenation in resting state and task periods in adults using fNIRS -- Development and validation of robust and cost-effective liquid heterogeneous phantom for time domain near-infrared optical tomography -- Effect of Exercise Therapy on Stress Response Evaluated by IoMT Monitoring System -- Improved optical tissue model for tissue oximetry imaging applications -- In vitro validation of a new tissue oximeter using visible light -- Photon and Proton Dose Painting based on Oxygen Distribution – Feasibility Study and Tumour Control Probability Assessment -- Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O2 Consumption of Tumour Cells -- Feasibility of non-invasive measurement of tumor NAD(H) by in vivo phosphorus-31 magnetic resonance spectroscopy -- Acidosis-induced regulation of Egr1 and Ccn1 in vitro and in experimental tumors in vivo -- Perfusion-Limited Hypoxia Determines the Outcome of Radiation Therapy of Hypoxic Tumours -- Improved Oxygenation of Human Skin, Subcutis and Superficial Cancers upon Mild Hyperthermia Delivered by wIRA-Irradiation -- Blood Supply and Oxygenation Status of the Liver: From Physiology to Malignancy -- Optical Redox Imaging Is Responsive to TGFβ Receptor Signaling in Triple-Negative Breast Cancer Cells -- Evaluation of betulinic acid derivatives as PET tracers for hypoxia-induced carbonic anhydrase IX (CA IX) expression -- Role of the mTOR signaling pathway during extracellular acidosis in tumor cells -- Feasibility Study of Remote Contactless Perfusion Imaging with Consumer-Grade Mobile Camera -- Stability of a Novel PEGylation site on a Putative Hemoglobin Based Oxygen Carrier -- Oxygen storage in stacked phospholipid membranes under an oxygen gradient as a model for myelin sheaths -- Confocal laser and electron microscopic investigation of gap junctions in anaplastic astrocytomas -- A radiation biological analysis of the oxygen effect as a possible mechanism in FLASH -- Assessment of nicotinamide adenine dinucleotide in human tissues by in vivo phosphorus-31 magnetic resonance spectroscopic imaging at 1.5 Tesla -- Drag-Reducing Polymers Improve Vascular Hemodynamics and Tissue Oxygen Supply in Mouse Model of Diabetes Mellitus -- Hemorheologic Enhancement of Cerebral Perfusion increases oxygen supply and reduces Ab plaques deposition in a mouse model of Alzheimer’s Disease -- Calorimetric Characterization of the Binding Reaction Between Human Ferric Hemoglobins and Haptoglobin to Develop a Drug for Removal of Cell-Free Haemoglobin -- Feasibility To Measure Tissue Oxygen Saturation Using Textile-integrated Polymer Optical Fibers -- Effect of Atorvastatin on Microcirculation Evaluated by Vascular Occlusion Test with Peripheral Near lnfrared Spectroscop -- Flow characteristics of the conjugate of anti-CD3 monoclonal antibodies and magnetic nanoparticle in the PBS and the blood vessel -- Cerebrovascular Reserve (CVR) and Stages of Hemodynamic Compromise -- On the mechanism of sustained mitochondrial membrane potential without functioning complex IV -- Further evidence that gradients of extracellular pH direct migration of MDA-MB-231 cells in vitro -- Blood Flow and Respiratory Gas Exchange in the Human Placenta at Term: A Data Update -- Oxyhaemoglobin Level Measured Using Near-Infrared Spectrometer is Associated with Brain Mitochondrial Dysfunction After Cardiac Arrest in Rats -- Changes in Oxygenation Levels During Moderate Altitude Simulation (Hypoxia-Induced): A Pilot Study Investigating the Impact of Skin Pigmentation in Pulse Oximetry -- The Intramuscular Circulation is Affected by Neck and Shoulder Pain -- Intramuscular circulation of the lumbar multifidus in different trunk positions on standing -- Numerical Optimization of a NIRS Device for Monitoring Tissue Oxygen Saturation -- Upper trapezius muscle tonicity, assessed by palpation, relates to change in tissue oxygenation and structure as measured by Time-Domain Near Infrared Spectroscopy -- Perceived exertion correlates with multiple physiological parameters during cardiopulmonary exercise testing -- Systemic and Quadriceps Muscle O2 Dynamics in Subjects without Attenuation Point of Deoxygenated Hemoglobin Concentration during Ramp Cycling Exercise -- Jaw-Clenching Intensity Effects on Masseter Oxygen Dynamics and Fatigue: A NIRS Oximetry Study. .

Description / Table of Contents: Chapter 1: GrpE, Hsp110/Grp170, HspBP1/Sil1 and BAG domain proteins: Nucleotide exchange factors for Hsp70 molecular chaperones -- Chapter 2: Functions of the Hsp90-Binding FKBP Immunophilins -- Chapter 3: Hsp70/Hsp90 organising protein (Hop): coordinating much more than chaperones -- Chapter 4: Specification of Hsp70 function by Hsp40 Co-Chaperones -- Chapter 5: Cdc37 as a Co-chaperone to Hsp90 -- Chapter 6: p23 and Aha1 – Distinct functions promote client maturation -- Chapter 7: Beyond chaperoning: UCS proteins emerge as regulators of myosin-mediated cellular processes -- Chapter 8: Chaperonin - Co-Chaperonin Interactions -- Chapter 9: Co-chaperones of the human endoplasmic reticulum: an update -- Chapter 10: J Domain Proteins Orchestrate the Multifunctionality of Hsp70s in Mitochondria: Insights from Mechanistic and Evolutionary Analyses -- Chapter 11: Impact of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity -- Chapter 12: CHIP: a co-chaperone for degradation by the proteasome and lysosome -- Chapter 13: HSP70-HSP90 chaperone networking in protein misfolding disease.

Description / Table of Contents: Chapter 1: Introduction: Progression of the Science of Ageing -- Chapter 2: Chromatin structure from development to ageing -- Chapter 3: The nuclear envelope in ageing and progeria -- Chapter 4: Mitochondrial DNA mutations and ageing -- Chapter 5: The Proteasome and Ageing -- Chapter 6: Gap junctions and Ageing -- Chapter 7: Cellular senescence and ageing -- Chapter 8: Therapeutic opportunities presented by modulation of cellular senescence -- Chapter 9: Ageing at Molecular Level: Role of MicroRNAs -- Chapter 10: CircRNAandAgeing -- Chapter 11: Extracellular vesicles and cellular ageing -- Chapter 12: Fibrinogen, Coagulation and Ageing -- Chapter 13: An Insight intoPlateletsat Older Age:Cellular and Clinical Perspectives -- Chapter 14: Ageing skeletal muscle: The ubiquitous muscle stem cell -- Chapter 15: Age-related changes in central nervous system 5-hydroxytryptamine signalling and its potential effects on the regulation of lifespan -- Chapter 16: Systems Biology of Ageing.

Description / Table of Contents: The Endocannabinoid System in Caenorhabditis Elegans -- Inherited Ventricular Arrhythmia in Zebrafish: Genetic Models and Phenotyping Tools -- The Biochemistry & Physiology of a Disintegrin and Metalloproteinases (ADAMs and ADAM-TSs) in Human Pathologies -- A Review: Uses of Chitosan in Pharmaceutical Forms -- Cell-to-Cell Crosstalk: A New Insight into Pulmonary Hypertension. .

Description / Table of Contents: Chapter 1. An Introduction To Cucurbits -- Chapter 2. Insect Pests And Non-Insect Pests Of Cucurbits -- Chapter 3. Mite Pests -- Chapter 4. Cvertbrate Pest -- Chapter 5. Deaseas Of Cucurbits And Their Management -- Chapter 6. Bacterial Diseases Of Cucurbits -- Chapter 7. Diseases Caused By Phytoplasmas -- Chapter 8. Post Harvest Disease -- Chapter 9. Viral Diseases -- Chapter 10. Eangiospermic Parasite -- Chapter 11. Diseases Caused By Nematodes -- Chapter 12. Weed And Its Management In Cucurbitaceous Vegetables -- Chapter 13. Abiotic Stresses: Nutritional And Physiological Disorders -- Chapter 14. Breeding of cucurbits for resistance against biotic stresses.

Description / Table of Contents: Cathepsin D in the tumor microenvironment of breast and ovarian cancers -- Galectins in the tumor microenvironment: Focus on galectin-1 -- Iron in the tumor microenvironment -- Oxygen in the tumor microenvironment: mathematical and numerical modeling -- Roles for Phospholipase D1 in the tumor microenvironment -- Leptin in tumor microenvironment -- The immune consequences of lactate in the tumor microenvironment -- Fatty acid mediators in the tumor microenvironment -- Extracellular Vesicles in the tumor microenvironment: various implications in tumor progression -- Index.

Description / Table of Contents: Preface -- Practical Aspects of NMR-Based Metabolomics -- Compound Identification in Mass Spectrometry-Based Metabolomics -- METABOLOMICS USING NMR – Avoiding the ‘Black-Box’ -- Natural products drug discovery: on silica or in silico?- Quantitative NMR Methods in Metabolomics -- Advancements in pulsed stable isotope resolved metabolomics -- Metabolomics in Cell Biology -- NMR-based metabolomics to evaluate individual response to treatments -- Pharmacometabolomics of Asthma as a road map to Precision Medicine -- Prospective metabolomic studies in precision medicine -- Chemotherapy-induced Peripheral Neuropathy -- Metabolomics of Respiratory Diseases.

Description / Table of Contents: Part 1. Light-sensitive channels and transporters -- 1. History and Perspectives of Light-Sensing Proteins -- 2. Phototactic behavior of Chlamydomonas -- 3. Structure-Functional Analysis of rhodopsin light sensors -- 4. Molecular Dynamics of Channelrhodopsin -- 5. Photochemistry of Halorhodopsin -- 6. Spectroscopic Dynamics of Microbial Rhodopsins -- 7. Molecular Engineering of Retinylidene Proteins -- 8. A new optogenetic tools from deep ocean -- Part 2. Light-sensitive signaling molecules -- 9. Biology of Light-Sensing Proteins in Plants and Microorganisms -- 10. Optogenetic Potentials of Diverse Animal Opsins -- 11. Enzyme rhodopsins -- 12.Optogenetic photoswitches -- 13.Genetic, biochemical and biophysical studies on flavoprotein photoreceptors -- Part 3. Optogenetics in Biological System -- 14. General Description: Future Prospects of Optogenetics -- 15. Optogenetic Manipulation and Probing -- 16. Visualization and Manipulation Signaling Molecules In Vivo -- 17. Optical Manipulation of Gene Expression -- 18. Optical Manipulation of Intracellular Signaling -- 19. Single Molecule Optogenetics -- 20. Bioluminescence Imaging -- 21. Luminescence Optogenetics -- 22. Optogenetic Imaging of Protein Activity in the Synapse Using 2-Photon Fluorescence Lifetime Imaging Microscopy -- 23. Optogenetics in Drosophila -- 24. Optogenetics in Caenorhabditis elegans -- 25. Optogenetics in zebrafish -- 26. Optogenetics Research Using the Mouse as a Model System -- 27. Optogenetics Research Using Rat -- 28. Optogenetics Research Using Primates -- 29. Organelle Optogenetics -- Part 4. Optogenetics in Neuroscience -- 30. Neuroscientific Frontline of Optogenetics -- 31. Elucidation of Neuronal Circuitry Involved in the Regulation of Sleep/Wakefulness Using Optogenetics -- 32. Multiscale neural activity in the behaving brain -- 33. Optogenetic Analysis of Striatal Connections to Determine Functional Connectomes -- 34. Optogenetics for the Behavior Manipulation of Non-human Primates -- 35. Activity Regulation in the Study of Neural Plasticity -- 36. Optogenetic Control of Synaptic Plasticity -- 37. Casting Light on the Role of Glial Cells in Brain Function -- 38. Optogenetic manipulation of Respiratory Rhythm -- 39. Optogenetic mapping of brain circuitry -- 40. In vivo imaging of Arc transcription -- 41. Neural Circuits for the Formation and Retrieval of Episodic Memories -- Part 5. Medical Optogenetics -- 42. Medical Optogenetics, Overview -- 43. Towards Understanding the Neural Mechanism of Behavioral Phenotypes Seen in Psychiatric Disorders -- 44. Gene Therapy Using Channelrhodopsins to Treat Blindness -- 45. Optogenetic Approaches to Restoring Intrinsic Visual Processing Features in Retinal Ganglion Cells -- 46. Application of optogenetics to epilepsy research -- Part 6. Opto-electro-nano Technologies for Optogenetics -- 47. CMOS-Based Neural Interface Device for Optogenetics -- 48. OLED System for Optogenetics -- 49. Micro-imaging probes, Opto-electrodes, and Virtual Reality Systems for Optogenetics -- 50. Upconversion -- 51. Optical probes for in vivo optogenetics.

Description / Table of Contents: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.

Description / Table of Contents: Oxidative stress and anti-oxidant strategies in human diseases -- Oxidative stress in the tumorimmune microenvironment -- Oxidative stress-mediated stem cell aging -- Stress proteins: Biological functions, human diseases and virus infections -- Importance of mitochondrial quality controls in Parkinson’s disease: the potential interplay of mitochondrial unfolded protein response and mitophagy -- Autophagy in cellular stress responses -- Cysteine metabolism in cancer progression and therapy resistance -- Stress and circadians -- ROS, glucose and lipid metabolism -- Drug repurposing: An avenue towards stress medicine in cancer therapy -- Redox regulation of metabolic enzymes in cancer -- Stress and inflammation -- Oxidative stress in cell signaling and cell fate determination under glucose starvation.

Description / Table of Contents: Foreword -- Ferroptosis: Concepts and Definitions -- Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT inhibitors -- Iron Homeostasis and Metabolism: Two Sides of a Coin -- The Role of NCOA4-mediated Ferritinophagy in Ferroptosis -- Emerging Role for Ferroptosis in Infectious Diseases -- Small Molecule Regulators of Ferroptosis -- Necroptosis, The other main Caspase-Independent Cell Death.

Description / Table of Contents: Part 1. Cellular and molecular mechanisms in inflammatory diseases -- Chapter 1. Vascular Diseases as mediator of systemic inflammation -- Chapter 2. Inflammation and gut microbiote -- Chapter 3. Cardioimmunology: na interdisciplinar approach -- Chapter 4. Cell therapy as strategy for respiratory Diseases -- Chapter 5. Mitochondrial dysfunction as a trigger of inflammation in cardiovascular diseases -- Chapter 6. Cancer therapy-induced inflammation and its consequences -- Chapter 7. Coupling glucose phosphorylation to oxygen in brain mitochondria: would it be redox set point? -- Chapter 8. Methods for the analysis of arachidonic acid-derived metabolites in platelets -- Part 2. Nanomedicines for inflammatory diseases -- Chapter 9. In vitro models and molecular markers for assessing nano-based systems inflammatory potential -- Chapter 10. Using micro- and nanocarriers for myocardial targeted delivery -- Chapter 11. Nano-based hydrogels for atopic dermatitis treatment -- Chapter 12. Nanomedicine applied to inflammatory bowel diseases -- Chapter 13. Nanomedicine therapies for macrophage-targeted delivery -- Chapter 14. Nano-based therapies for pulmonary inflammatory diseases -- Chapter 15. Pulmonary inflammation treated by nanocarriers.

Description / Table of Contents: The Origin of Eukaryotic Cells and Multicellular Organisms -- Multicellular Organisms Propagation -- Grow Fast and Well or Die -- Why Do Animals Grow, Age and then Die? -- How Do Tissues Regenerate After an Injury? Epilog. The Future of Humankind Could Depend on Unicellular Life.

Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Around the Circadian Clock: Review and Preview -- Chapter 3. A retrospective: on disproving the transcription-translation feedback loop model in cyanobacteria -- Chapter 4. Mechanistic Aspects of the Cyanobacterial Circadian Clock -- Chapter 5. Mechanism of the cyanobacterial circadian clock protein KaiC to measure 24 hours -- Chapter 6. Oscillation and Input Compensation in the Cyanobacterial Kai Proteins -- Chapter 7. Insights into the Evolution of Circadian Clocks Gleaned from Bacteria -- Chapter 8. Reasons for Seeking Information on the Molecular Structure and Dynamics of Circadian Clock Components in Cyanobacteria -- Chapter 9. Single-molecule methods applied to circadian proteins with special on atomic force microscopy -- Chapter 10. Diversity of timing systems in Cyanobacteria and beyond -- Chapter 11. An In Vitro Approach to Elucidating Clock-modulating Metabolites -- Chapter 12. Damped Oscillation in the Cyanobacterial Clock System -- Chapter 13. Roles of phosphorylation of KaiC in the cyanobacterial circadian clock -- Chapter 14. Reprogramming metabolic networks and manipulating circadian clocks for biotechnological applications -- Chapter 15. Insights from Mathematical Modeling/Simulations of the in vitro KaiABC clock -- Chapter 16. Basic Biology of Rhythms & the Microbiome -- Chapter 17. Disease Implications of the Circadian Clocks and Microbiota Interface -- Chapter 18. Circadian organization of the gut commensal bacterium Klebsiella aerogenes -- Chapter 19. Daily rhythmicity in coastal microbial mats -- Chapter 20. Daily and Seasonal Rhythms of Marine Phages of Cyanobacteria.

Description / Table of Contents: Drosophila Satellite Repeats at the Intersection of Chromatin, Gene Regulation and Evolution -- Structure, Organization and Evolution of Satellite DNAs: Insights from the Drosophila repleta and D. Virilis Species Groups -- Exploring Satellite DNAs: Specificities of Bivalve Mollusks Genomes -- Satellite DNA is an Inseparable Fellow Traveller of B Chromosomes -- The Genomics of Plant Satellite DNA -- Satellite DNA-Mediated Gene Expression Regulation: Physiological and Evolutionary Implication -- Centromeres Transcription and Transcripts for Better and for Worse -- Global Repeat Map (GRM) - Advantageous Method for Discovery of Largest Higher Order Repeats (HORs) in Neuroblastoma Breakpoint Family (NBPF) Genes, in Hornerin Exon and in Chromosome 21 Centromere.

Description / Table of Contents: Chapter 1 General Thinking About Inflammation -- Chapter 2 Inflammation from the Standpoint of Leukocytes -- Chapter 3 Vessels and Coagulation -- Chapter 4 Sterile Inflammation -- Chapter 5 Issue of Self and Non-self -- Chapter 6 Extension of Endogenous Field -- Chapter 7 Evidence for Existence of Endogenous TLR4 Ligands -- Chapter 8 Autoinflammatory Disorders -- Chapter 9 Cancer in General -- Chapter 10 Basic Research -- Chapter 11 Tumor Microenvironment -- Chapter 12 Whole-Body Matter -- Chapter 13 Premetastatic Microenvironment -- Chapter 14 What Is Homeostasis? -- Chapter 15 Explanation of Metastasis by Homeostatic Inflammation -- Chapter 16 Therapeutic Potential.