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  • Books  (4)
  • Cytology.
  • Cham :Springer International Publishing :  (4)
  • 612.8  (4)
  • 1
    Online Resource
    Online Resource
    Neurosecretion: Secretory Mechanisms (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Anatomy. ; Internal medicine. ; Cytology. ; Biochemistry. ; Neuroscience. ; Anatomy. ; Internal Medicine. ; Cell Biology. ; Biochemistry.
    Description / Table of Contents: Neurosecretion: A Historical Overview -- Neurosecretion: Hypothalamic Somata versus Neurohypophysial Terminals -- Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus -- Somato-Dendritic Secretion of Neuropeptides -- Neurosecretory Vesicles: Structure, Distribution, Release and Breakdown -- Molecular Controls on Regulated Neurotransmitter and Neurohormone Secretion -- Secretory Astrocytes -- Action Potential-Induced Ca2+ Influx for Both Acute and Sustained Insulin Secretion in Pancreatic Beta Cells -- Plasticity in the Morphology of Lactotrophs and Folliculo-Stellate Cells and Prolactin Secretion -- Neuroendocrine and Metabolic Regulation of Plasma Growth Hormone Secretory Profiles -- Role of the TWIK-Related Potassium (TREK)-1 Channels in the Regulation of Adrenocorticotropic Hormone (ACTH) Secretion from Pituitary Corticotropes -- How Do Bacterial Neurotoxins Affect Neurosecretion? -- Secretory Mechanisms in Paramecium.
    Abstract: How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state‐dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted. While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley.
    Type of Medium: Online Resource
    Pages: XIII, 307 p. 65 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030229894
    Series Statement: Masterclass in Neuroendocrinology, 8
    URL: https://doi.org/10.1007/978-3-030-22989-4
    DOI: 10.1007/978-3-030-22989-4
    DDC: 612.8
    Language: English
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  • 2
    Online Resource
    Online Resource
    Calcium Signaling (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Proteins. ; Cytology. ; Neuroscience. ; Proteins. ; Cell Biology.
    Description / Table of Contents: Preface -- Calcium signaling: from basics to bedside -- Measuring Ca2+ in living cells -- High-throughput fluorescence assays for Ion Channels and GPCRs -- Imaging Native Calcium Currents in Brain Slices -- Molecular diversity of plasma membrane Ca2+ transporting ATPases: their function under normal and pathological conditions -- A role for SERCA pumps in the neurobiology of neuropsychiatric and neurodegenerative disorders -- Cytoplasmic Calcium Buffering: An Integrative Crosstalk -- An update on calcium binding proteins -- Manuel Campos‐Toimil -- New insights in the IP3 receptor and its regulation -- Expression of the inositol 1,4,5-trisphosphate receptor and the ryanodine receptor Ca2+-release channels in the beta-cells and alpha- cells of the human islets of Langerhans -- Evolution of Excitation-Contraction Coupling -- Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels -- Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content visualized from the luminal side -- Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores -- Calcium Signaling in the Heart -- Molecular basis and regulation of store-operated calcium entry -- Structure and activation mechanisms of CRAC channels -- Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells -- Pathophysiological significance of store-operated calcium entry in cardiovascular and skeletal muscle disorders and angiogenesis -- Calcium signalling and the regulation of chemosensitivity in cancer cells: role of the Transient Receptor Potential channels -- Targeting Transient Receptor Potential Channels by microRNAs drives tumor development and progression -- Calcium channels and Calcium-regulated channels in human red blood cells -- Regulation of multifunctional calcium/calmodulin stimulated protein kinases by molecular targeting -- Widespread roles of CaMK-II in Developmental Pathways -- Readily releasable stores of calcium in neuronal endolysosomes: Physiological and pathophysiological relevance -- At the crossing of ER stress and MAMs: A key role of Sigma-1 receptor?- ER-mitochondria calcium transfer, organelle contacts and neurodegenerative diseases -- The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells -- Calcium Signaling and Gene Expression -- Simulation Strategies for Calcium Microdomains and Calcium Noise -- A statistical view on calcium oscillations -- Calcium Regulation of Bacterial Virulence -- Ca2+ Signaling in Drosophila Photoreceptor Cells -- Calcium imaging in Drosophila melanogaster -- Calcium imaging in the zebrafish -- Stimulation-secretion coupling in the beta cells: from basic to bedside -- Calcium dynamics and synaptic plasticity -- Calcium signaling during brain aging and its influence on the hippocampal synaptic plasticity -- Calcium Signaling in Endothelial Colony Forming Cells in Health and Disease -- Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR) -- Extracellular Ca2+ in bone marrow -- Calcium in Cell-Extracellular Matrix Interactions -- Index.
    Abstract: This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative. The chapter “Calcium Signaling: From Basic to Bedside” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XIII, 1110 p. 150 illus., 132 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030124571
    Series Statement: Advances in Experimental Medicine and Biology, 1131
    URL: https://doi.org/10.1007/978-3-030-12457-1
    DOI: 10.1007/978-3-030-12457-1
    DDC: 612.8
    Language: English
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  • 3
    Online Resource
    Online Resource
    Molecular Mechanisms of Neurotransmitter Release (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Cytology. ; Zoology. ; Neurology . ; Neuroscience. ; Cell Biology. ; Zoology. ; Neurology.
    Description / Table of Contents: The Architecture of the Presynaptic Release Site.-Cytomatrix Proteins in Presynaptic Terminal. - Multiple Modes of Fusion and Retrieval at the Calyx of Held Synapse -- Roles of SNARE Proteins in Synaptic Vesicle Fusion -- Calcium Sensors of Neurotransmitter Release. - Roles and Sources of Calcium in Synaptic Exocytosis -- Regulation of Presynaptic Calcium Channels -- Roles of mUnc13/UNC-13 and mUnc18/UNC-18 in Neurotransmitter Release. - The role of tomosyn in the regulation of neurotransmitter exocytosis. -Roles of complexins in Neurotransmitter Release. -Regulation of Neurotransmitter Release by AIPR-1/AIP and calstabins. - The Role of Potassium Channels in the Regulation of Neurotransmitter Release -- Roles of Neuropeptides in Synaptic Function. - Transsynaptic Regulation of Presynaptic Release Machinery in Central Synapses by Cell Adhesion Molecules. - Lipids and Secretory Vesicle Exocytosis -- Synaptic Vesicle Endocytosis.
    Abstract: Neurons communicate with each other by releasing neurotransmitters. This book provides comprehensive coverage of the molecular mechanisms involved in neurotransmitter release. The topics covered in the book range from the architecture and cytomatrix proteins of presynaptic sites, to the modes of synaptic vesicle exocytosis (full-collapse and kiss-and-run), and from the key molecules mediating synaptic vesicle fusion (SNAREs) to those that closely interact with them (UNC-13/Munc13, UNC-18/Munc18, tomosyn, and complexins). The book also delves into the calcium sensors of synaptic vesicle fusion (synaptotagmins and Doc2s), the sources of calcium that trigger synaptic exocytosis (voltage-gated calcium channels and ryanodine receptors), and the regulation of neurotransmitter release by potassium channels, cell adhesion molecules, lipids, aryl hydrocarbon receptor-interacting protein (AIP), presenilins, and calstabins. To aid in understanding and illustrate key concepts, the book includes sufficient background information and a wealth of illustrations and diagrams. The new edition includes major updates to previous chapters, as well as several new chapters that reflect the recent advances in the field. Comprehensive and cutting-edge, Molecular Mechanisms of Neurotransmitter Release, 2nd edition, is a valuable learning resource for neuroscience students and a solid reference for neuroscientists.
    Type of Medium: Online Resource
    Pages: XI, 401 p. 77 illus., 62 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031342295
    Series Statement: Advances in Neurobiology, 33
    URL: https://doi.org/10.1007/978-3-031-34229-5
    DOI: 10.1007/978-3-031-34229-5
    DDC: 612.8
    Language: English
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  • 4
    Online Resource
    Online Resource
    Distributed Vision : From Simple Sensors to Sophisticated Combination Eyes (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Cytology. ; Ecology . ; Neural circuitry. ; Neuroscience. ; Cell Biology. ; Ecology. ; Neural Circuits.
    Description / Table of Contents: 1. Introduction -- 2. Diversity and evolution of jellyfish visual systems, Mollusks -- 3. Scallops distributed eyes -- 4. Chiton dispersed visual systems, Annelids -- 5. Errant polychaetes Arthropods -- 6. Spider eyes -- 7. Myriapod eyes -- 8. Insect ocelli -- 9. Batflies, copepods or larval stomatopods -- 10 -- Hyperiid amphipods, Echinoderms -- 11. Brittle star vision -- 12. Starfish vision.
    Abstract: This volume explores the diversity of distributed eyes and other unusual visual systems in nature. It compares the unique themes of optics, neural processing, and behavioral control that emerge from these visual systems with more-canonical eyes. This volume attempts to answer a number of questions about distributed visual systems. What are distributed visual systems good for, how do they function, and why have they arisen independently in so many phyla? Why are eye designs and visual system arrangements much more diverse in invertebrates? Each chapter includes an overview of the visual systems that exist in their group of animals, relates vision to ecology, and takes a comparative approach. .
    Type of Medium: Online Resource
    Pages: VII, 320 p. 70 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031232169
    Series Statement: Springer Series in Vision Research,
    URL: https://doi.org/10.1007/978-3-031-23216-9
    DOI: 10.1007/978-3-031-23216-9
    DDC: 612.8
    Language: English
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