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  • 1
    Online Resource
    Online Resource
    Handbook of 200 Medicinal Plants : A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Medicinal chemistry. ; Pharmacology. ; Pharmacy. ; Medicinal Chemistry.
    Description / Table of Contents: Abelmoschus maschatus -- Abrus precatorius -- Abutilon indicum -- Acacia catechu -- Acacia nilotica (A. arabica) -- Achillea millefolium -- Achyranthes aspera -- Aconitum napellus -- Acorus calamus -- Adiantum venustum (Adiantun capillus-veneris) -- Aegle marmelos -- Agrimonia eupatorium.-Alhagi maurorum -- Alkanna tinctoria -- Allium cepa -- Allium sativum -- Aloe vera -- Alpinia galangal -- Alpinia officinarum -- Alstonia scholaris -- Althaea officinalis -- Ammi majus -- Anacardium occidentale -- Anacyclus pyrethrum -- Andrographis paniculata -- Anethum graveolens -- Anthemis nobilis -- Apium graveolens -- Argemone Mexicana -- Aristolochia bracteolata -- Aristolochia fontanesii (A. longa) -- Aristolochia indica -- Aristolochia rotunda -- Artemisia absinthium -- Artemisia vulgaris -- Asparagus adscendens -- Asparagus officinalis -- Asparagus racemosus -- Atropa belladonna -- Azadirachta indica -- Bacopa monnieri -- Bauhinia tomentosa -- Berberis Aristata -- Berberis vulgaris -- Bombyx mori -- Borago officinalis -- Boswellia serrata -- Brassica nigra -- Butea monosperma -- Caccinia macranthera var. glauca (C. glauca) -- Caesalpinia bonduc (Caesalpinia bonducella) -- Cannabis sativa -- Capparis spinosa -- Cardiospermum halicacabum -- Carthamus tinctorius -- Carum carvi -- Cassia fistula -- Catharanthus roseus -- Celastrus paniculatus -- Centaurea behen -- Centella asiatica -- Chamaecrista absus (Cassia absus) -- Chamaemelum nobile (Anthemis nobilis) -- Cheilocostus speciosus (Costus Speciosus) -- Cichorium intybus -- Cinnamomum camphora -- Cinnamomum cassia -- Cinnamomum verum (C. zeylanicum) -- Citrullus colocynthis -- Clitoria ternatea -- Colchicum autumnale -- Colchicum luteum -- Commiphora gileadensis (C. opobalsamum) -- Commiphora myrrha -- Commiphora wightii (C. mukul) -- Convolvulus scammonia -- Cotoneaster nummularius -- Crocus sativus -- Croton tiglium -- Cullen corylifolium (Psoralea corylifolia) -- Cuminum cyminum -- Curcuma aromatica -- Curcuma longa -- Curcuma zedoaria -- Cuscuta chinensis -- Cuscuta reflexa -- Cydonia oblonga -- Cymbopogon schoenanthus -- Cyperus rotundus -- Datura stramonium -- Delphinium denudatum -- Dolichousnea longissimi (Usnea longissima) -- Doronicum pardalianches -- Embelia ribes -- Euphorbia hirta -- Euphorbia resinifera -- Ferula assa-foetida -- Ficus carica -- Ficus racemosa -- Foeniculum vulgare -- Fumaria officinalis -- Gentiana lutea -- Glycyrrhiza glabra -- Gymnema sylvestre -- Helleborus niger -- Hemidesmus Indicus -- Hibiscus rosa-sinensis -- Holarrhena pubescens (Holarrhena antidysenterica) -- Hyoscyamus niger -- Hyssopus officinalis -- Illicium verum -- Iris germanica -- Juniperus communi -- Justicia adhatoda (Adhatoda vasica) -- Lactuca sativa -- Lavandula stoechas -- Lawsonia inermis -- Lepidium sativum -- Linum usitatissimum -- Lupinus albus -- Malva sylvestris -- Marrubium vulgare -- Matricaria chamomilla -- Melia azedarach -- Melilotus officinalis -- Melissa officinalis -- Mesua ferrea -- Momordica charantia -- Moringa oleifera -- Myristica fragrans -- Myrtus communis -- Nageia nagi -- Nepeta cataria -- Nigella sativa -- Ocimum basilicum -- Ocimum gratissimum -- Ocimum tenuiflorum (Ocimum sanctum -- Operculina turpethum -- Paeonia emodi -- Pandanus odorifer (Pandanus Odoratissimus) -- Papaver somniferum -- Persicaria bistorta -- Phyllanthus emblica (Emblica officinalis) -- Picrorhiza kurroa -- Pimpinella anisum -- Piper cubeba -- Piper nigrum -- Pistacia lentiscus -- Plantago major -- Plantago ovata -- Plumbago zeylanica -- Polygonum aviculare -- Portulaca oleracea -- Quercus infectoria -- Rauvolfia serpentina -- Rheum emodi -- Rheum officinale -- Ricinus communis -- Rubia cordifolia -- Rumex vesicarius -- Ruta graveolens -- Salix caprea -- Salvia officinalis -- Santalum album -- Saussurea lappa -- Semecarpus anacardium -- Senna alexandrina -- Senna occidentalis -- Senna tora -- Sida cordifolia -- Smilax china;- Solanum americanum (S. nigrum) -- Sterculia urens -- Strychnos nux-vomica -- Swertia chirata -- Symplocos racemosa -- Syzygium cumini (Eugenia jambolana) -- Tamarindus indica -- Taraxacum officinale -- Taxus baccata -- Tephrosia purpurea -- Terminalia bellirica -- Terminalia chebula -- Thymus vulgaris -- Tinospora cordifolia -- Trachyspermum ammi (Ptychotis coptica) -- Tribulus terrestris -- Trigonella foenum-graecum -- Tussilago farfara -- Valeriana jatamansi (Nardostachys jatamansi) -- Verbena officinalis -- Vernonia anthelmintica (Baccharoides anthelmintica) -- Vigna unguiculata (Dolichos biflorus) -- Viola odorata -- Viscum album -- Withania somnifera -- Wrightia tinctoria -- Zingiber officinale -- Zingiber zerumbet -- Ziziphus jujuba -- Abbreviations -- Glossary -- Ayurvedic Terms of Diseases -- List of Referenced Books -- Index.
    Abstract: This book is designed to provide pharmacologists and researchers of natural products a comprehensive review of 200 medicinal plants, their vernacular names in various languages and their medicinal uses around the world, and in some cases, a historical perspective. Chemical constituents of each plant with the putative active constituent, and available up to date pharmacological studies (until 2017 on PubMed) with each medical activity explored and its relationship with traditional uses, are described for each plant. Any variations in chemical constituents and their effects on pharmacological studies outcome have been highlighted. All clinical trials conducted, with sufficient details, have been included. Nationalities and racial identities of participants of clinical trials are identified to impress upon the social, cultural and dietary influences on the clinical outcomes. Toxicity studies and potential interactions with prescribed drugs, and full spectrum of references are included.
    Type of Medium: Online Resource
    Pages: XXX, 2156 p. 199 illus., 198 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030168070
    URL: https://doi.org/10.1007/978-3-030-16807-0
    DOI: 10.1007/978-3-030-16807-0
    DDC: 615
    Language: English
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  • 2
    Online Resource
    Online Resource
    Network Pharmacology (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Bioinformatics. ; Pharmacology. ; Pharmacy. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. 'Network Target' Theory and Network Pharmacology -- Chapter 2. Application of Network Pharmacology Based on Artificial Intelligence Algorithm in Drug R & D -- Chapter 3. Commonly used Network Pharmacology Database -- Chapter 4. Commonly used Network Pharmacology Software -- Chapter 5. Network Pharmacology and TCM Modernization Case Studies -- Chapter 6. Network Pharmacology and Modern Drug R & D Cases -- Chapter 7. Drug-based Network Pharmacology Practice Process -- Chapter 8. Disease-based Network Pharmacology Practice Process -- Chapter 9. Drug-disease-based Network Pharmacology Practice Process.
    Abstract: This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
    Type of Medium: Online Resource
    Pages: XVII, 468 p. 163 illus., 119 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811607530
    URL: https://doi.org/10.1007/978-981-16-0753-0
    DOI: 10.1007/978-981-16-0753-0
    DDC: 615
    Language: English
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  • 3
    Online Resource
    Online Resource
    The Carbonic Anhydrases: Current and Emerging Therapeutic Targets (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy.
    Description / Table of Contents: Dedication -- Preface.-The carbonic anhydrases in health and disease -- Carbonic anhydrase isozymes as diagnostic biomarkers and therapeutic targets -- Targeting carbonic anhydrases in vascular and pulmonary disease -- Carbonic anhydrase inhibitors in ophthalmology: glaucoma and macular oedema -- Targeting carbonic anhydrase isozymes in the treatment of neurological disorders -- Potential of carbonic anhydrase inhibitors in the treatment of oxidative stress and diabetes -- An overview of carbonic anhydrase-related neoplasms -- The carbonic anhydrase IX interactome and the regulation of cancer progression -- Carbonic anhydrase IX: current and emerging therapies -- Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents -- Carbonic anhydrase inhibitors: identifying therapeutic cancer agents through virtual screening -- Targeting carbonic anhydrase IX in tumour imaging and theranostic cancer therapy.
    Abstract: This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
    Type of Medium: Online Resource
    Pages: XII, 288 p. 38 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030795115
    Series Statement: Progress in Drug Research, 75
    URL: https://doi.org/10.1007/978-3-030-79511-5
    DOI: 10.1007/978-3-030-79511-5
    DDC: 615
    Language: English
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  • 4
    Online Resource
    Online Resource
    From PharmD to Industry : A Fellowship Guide (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Career education. ; Pharmacology. ; Pharmacy. ; Career Skills.
    Description / Table of Contents: Fellowship 101 -- The First Professional Year (P1) -- The Second Professional Year (P2) -- The Third Professional Year (P3) -- The Fourth Professional Year (P4) -- Midyear Applications, Interviews, and Receptions -- Transitioning from Student to Fellow -- Navigating the Virtual Landscape.
    Abstract: For many Doctor of Pharmacy (PharmD) candidates, post-graduate training is a highly prestigious and sought after experience that can further one’s pre-existing education. Some of these post-graduate training opportunities include but are not limited to pharmacy residencies, pharmaceutical industry fellowships, and PhD/Masters programs. There is a large gap in the current Doctor of Pharmacy curriculum about pharmaceutical industry fellowship programs and potential pharmaceutical industry opportunities. Through the eyes of current industry fellows and professionals, this book serves as a resource to learn more about fellowship opportunities and their respective application processes. In addition, this manual aims to provide a clear and concise roadmap to achieving a career in industry through a fellowship program. Whether you are a current student pharmacist, post-graduate pharmacy trainee (pharmacy resident), or industry professional, this manual addresses the current landscape of industry fellowship programs, an overview of industry opportunities, and a glimpse into what being a fellow entails. Readers of this book can expect to gain: An overview of pharmaceutical industry fellowship programs and opportunities Helpful advice and insight from current fellows and industry professionals A streamlined pathway to navigating the fellowship application process An understanding of the journey from being a student, to achieving a fellowship, to becoming an industry professional This book bridges the gap in education surrounding pharmaceutical industry fellowships and pharmacy careers in industry and increases access to first-hand information and real-world perspectives of current professionals to provide a firm foundation for those interested in pursuing a career in industry or learning more about fellowship programs.
    Type of Medium: Online Resource
    Pages: XIX, 92 p. 4 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031357879
    Series Statement: SpringerBriefs in Pharmaceutical Science & Drug Development,
    URL: https://doi.org/10.1007/978-3-031-35787-9
    DOI: 10.1007/978-3-031-35787-9
    DDC: 615
    Language: English
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  • 5
    Online Resource
    Online Resource
    Contract Research and Development Organizations-Their History, Selection, and Utilization (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Pharmacology. ; Pharmacy.
    Description / Table of Contents: Introduction -- History of CROs: Including CRO Snapshots and a CRO Genealogy Chart -- The Pharmaceutical Development Process & Testing Requirements -- The Medical Device Development Process & Testing Requirements -- Functions and Types of CROs -- Labs in China and India -- Selection of CROs -- Study Directors and PIs -- Nuts and Bolts of Study Performance SCG/CBS -- Electronic Reporting Requirements (SEND & eCTD) -- Study and Project Monitoring -- Contracting, Pricing, and Cost of Works Performed by CROs -- Consultants and their Role -- Building Relationships: Maximizing your return on Expectations with a CRO -- Common Problems and their Solutions -- Appendices: A Toxicology Labs B Medical Device Labs C Phase I Labs D Analytical Labs E GMP Contract Facilities F Formulation G Dosage Forms H Clinical Testing I Regulatory Services J Forms and Checklists -- K Specialized Services -- L Consultants Known to be In-Practice -- Index. .
    Abstract: This volume provides a complete update of all the materials in prior volumes on the subject (including current directories to testing labs and other support establishments worldwide), while adding substantial new material on the following topics: · The history of CROs, including snapshots of CROs and a genealogy chart making clear where they came from and where they went. · Study directors and principal investigators. · The nuts and bolts of study performance. · Electronic reporting requirements – SEND and eCTD (required for NDA, BLA, ANDA, and IND submissions). · Consultants and their roles. · An expanded examination of common problems and their solutions. This book boasts complete directories to the global universe of operating labs – where they are, how to contact them, and what they do (including special capabilities). Additionally, checklists for qualifying labs and manufacturing facilities – and for auditing studies and projects at such facilities – are included. It is directed at those in industry (specifically directed at those working for companies using CRO services) but will also be of interest to scientists or administrators working in research organizations themselves. In this case, the contents of this new work are essential to the target reader because the work, regulations, and actors (CROs) have evolved and changed at a rapid pace in the 10 years since the earlier volume that the author published. Likewise, the companies using these services have come to all be almost completely dependent on outsourcing. The earlier texts remain the only source of their kind (paper or electronic) on the field and the only noncommercial guide to the global industry and this volume provides a complete update.
    Type of Medium: Online Resource
    Pages: XIII, 519 p. 19 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030430733
    URL: https://doi.org/10.1007/978-3-030-43073-3
    DOI: 10.1007/978-3-030-43073-3
    DDC: 615
    Language: English
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  • 6
    Online Resource
    Online Resource
    Antiviral Drug Discovery and Development (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Biotechnology.
    Description / Table of Contents: 1 Antiviral Drugs Against Herpesviruses -- 2 An Update on Antiretroviral Therapy -- 3 Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and their Inhibition -- 4 LEDGINs, Inhibitors of the Interaction between HIV-1 Integrase and LEDGF/p75, are Potent Antivirals with a Potential to Cure HIV Infection -- 5 Moving Fast Towards Hepatitis B Virus Elimination -- 6 Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection -- 7 Phytoconstituents as Lead Compounds for Anti-dengue Drug Discovery -- 8 Anti-influenza Drug Discovery and Development: Targeting the Virus and its Host by all -- 9 Search, Identification and Design of Effective Antiviral Drugs against Pandemic Human Coronaviruses -- 10 Peptide Based Antiviral Drugs -- 11 Covalent Antiviral Agents -- 12 Safe-in-Man Broad Spectrum Antiviral Agents -- 13 Exploiting Ubiquitin ligases for Induced Target Degradation as an Antiviral Strategy. .
    Abstract: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
    Type of Medium: Online Resource
    Pages: XI, 357 p. 142 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602672
    Series Statement: Advances in Experimental Medicine and Biology, 1322
    URL: https://doi.org/10.1007/978-981-16-0267-2
    DOI: 10.1007/978-981-16-0267-2
    DDC: 615
    Language: English
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  • 7
    Online Resource
    Online Resource
    Marine Biomaterials : Drug Delivery and Therapeutic Applications (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medicine Research. ; Biology Research. ; Biomaterials. ; Pharmacy. ; Biomedical engineering. ; Pharmacology. ; Biomedical Research. ; Biomaterials. ; Pharmacy. ; Translational Research. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1. Marine biopolymers for oral delivery of drug -- Chapter 2. Marine polymer based nanocarriers for drug delivery application -- Chapter 3. Alginate: A promising biopolymer in drug delivery system -- Chapter 4. Chitosan Based Nanocomposite as Targeted drug delivery Carrier -- Chapter 5. Marine Biopolymer Based Oral In situ Gel: Drug Delivery Applications -- Chapter 6. Marine biopolymers for transdermal drug delivery -- Chapter 7. Marine polysaccharides for skin drug delivery: hydrogels and microneedles solutions -- Chapter 8. Marine collagen: promising biomaterial in delivery of therapeutics for cancer therapy -- Chapter 9. Chitosan based gel for ocular drug delivery. Chapter 10. Marine based biopolymers for central nervous system drug delivery -- Chapter 11. Marine Biopolymers Based Anticancer Drug Delivery Systems -- Chapter 12. Marine-Derived polysaccharides: prospects for future pharmaceuticals and drug delivery systems.
    Abstract: This book is focused on marine based biomedical carriers for delivery of therapeutics. Marine biomaterials and bio-based carriers show wide applications in pharmaceutical as well as biomedical fields for delivery of small and large molecules. Biomaterial-based composites, scaffolds or matrix systems are promising systems for controlled and prolonged release of drug in target site and control the premature release of drugs or bioactive compounds. This book discusses the targeted delivery of drugs and therapeutic applications. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. The marine biomaterial-based systems are widely used for tissue engineering, and biomedical imaging. This book is meant for industry experts, students and researchers in the area of pharmaceutical sciences, biomedical engineering and material science and pharmacology.
    Type of Medium: Online Resource
    Pages: X, 453 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811647871
    URL: https://doi.org/10.1007/978-981-16-4787-1
    DOI: 10.1007/978-981-16-4787-1
    DDC: 615
    Language: English
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  • 8
    Online Resource
    Online Resource
    Herb-Drug Combinations : A New Complementary Therapeutic Strategy (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Alternative medicine. ; Pharmacovigilance. ; Medicinal chemistry. ; Pharmacology. ; Pharmacy. ; Complementary and Alternative Medicine. ; Drug Safety and Pharmacovigilance. ; Medicinal Chemistry.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Measuring Herb-drug interaction and Synergy -- Chapter 3. Herb-Herb and Food-drug interactions -- Chapter 4. Pharmacokinetic interactions in synergistic herb-drug combinations -- Chapter 5. Antagonistic Herb-drug interactions -- Chapter 6. Synergistic Herb-drug interactions against bacteria -- Chapter 7. Synergistic herb-drug interactions against tuberculosis -- Chapter 8. Synergistic herb-drug interactions against viral diseases -- Chapter 9. Synergistic herb interactions with cardiovascular drugs -- Chapter 10. Synergistic herb interactions with anticancer drugs -- Chapter 11. Synergistic herb interactions with antidiabetic drugs -- Chapter 12. Synergistic herb-drug interactions against obesity -- Chapter 13. Synergistic Herb-Drug Interactions in Neurological Disorders -- Chapter 14. Synergistic Herb-drug interactions with antifungal and antiparasitic agents -- Chapter 15. Computational methods to study herb-drug interactions -- Chapter 16. Regulations and guidelines involving synergistic plant-drug interactions -- Chapter 17. Clinical trials on synergistic herb-drug interactions -- Chapter 18. QFuture prospects on synergistic herb-drug interactions -- Chapter 19. Conclusion.
    Abstract: Plant extracts or their pure natural constituents have been used traditionally for thousands of years for treating diseases with considerable success in India and other Asian countries. In addition, they have also been used as complements or supplements with conventional medicine. This book discusses the latest research in the application of combination therapy, namely herbs and drugs, in the treatment of a range of communicable and non-communicable diseases to achieve a synergistic effect. This synergy may help in reducing the amount of drug, its toxicity, side effects, and development of resistance as well as improve its efficacy. The book also discusses the pharmacodynamic and pharmacokinetic parameters, experimental tools to determine the impact of combination, computational approaches to identify synergy, statistical analysis of data, and clinical and regulatory issues. The book is useful for researchers in the fields of pharmacology, pharmacy and medicinal chemistry and those working in pharmaceutical and nutraceutical industries. This book could open up new strategies to focus on multiple targets to combat complex diseases unlike the single targeted drugs that are being currently marketed by the pharmaceuticals industries.
    Type of Medium: Online Resource
    Pages: XV, 276 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811951251
    URL: https://doi.org/10.1007/978-981-19-5125-1
    DOI: 10.1007/978-981-19-5125-1
    DDC: 615
    Language: English
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  • 9
    Online Resource
    Online Resource
    Climate Change Impacts on Water Resources : Hydraulics, Water Resources and Coastal Engineering (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Earth sciences. ; Physical geography. ; Natural disasters. ; Water. ; Earth Sciences. ; Earth System Sciences. ; Natural Hazards.
    Description / Table of Contents: Trend analyses of seasonal mean temperature Series pertaining to Tapi river basin, using monthly data -- . Dry and wet spell characterization of Naini river basin, western Maharashtra, India -- Assessment of Climate Change on Crop Water Requirement in Tandula Command of Chhattisgarh (India) -- Impact of climate change on hydrological regime of Narmada river basin -- Climate change impacts on water resource in Ethiopia -- Spatio-temporal trend analysis of long term IMD gridded precipitation in Godavari river basin, India -- Forecasting reference evapotranspiration using artificial neural network for Nagpur Region -- Assessment of extremes using time varying downscaling model -- Assessment of impact of land use land cover and climate change on quality of river using water quality index -- Assessment of tail behavior of probability distributions of daily precipitation data over India -- Probabilistic prediction of monthly streamflow using graphical modeling approach. .
    Abstract: This book provides insights and a capacity to understand the climate change phenomenon, its impact on water resources, and possible remedial measures. The impact of climate change on water resources is a global issue and cause for concern. Water resources in many countries are extremely stressed, and climate change along with burgeoning populations, the rise in living standards, and increasing demand on resources are factors which serve to exacerbate this stress. The chapters provide information on tools that will be useful to mitigate the adverse consequences of natural disasters. Fundamental to addressing these issues is hydrological modelling which is discussed in this book and ways to combat climate change as an important aspect of water resource management.
    Type of Medium: Online Resource
    Pages: XVI, 551 p. 223 illus., 199 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030642020
    Series Statement: Water Science and Technology Library, 98
    URL: https://doi.org/10.1007/978-3-030-64202-0
    DOI: 10.1007/978-3-030-64202-0
    DDC: 551.48
    Language: English
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  • 10
    Online Resource
    Online Resource
    Force Majeure in the Hydropower Industry : Concepts and Case Studies (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Water-power. ; Environmental Law. ; Environment. ; Earth sciences. ; Water. ; Hydroenergy. ; Environmental Law. ; Environmental Sciences. ; Earth Sciences.
    Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Water for energy versus energy for water -- Chapter 3. Energy sectors that use water -- Chapter 4. The context of the development of the World hydropower sector -- Chapter 5. The impact of drought on the hydropower domain -- Chapter 6. Force majeure -- Chapter 7. Sample contractual provisions, which must be contained in a force majeure contract -- Chapter 8. Concrete cases of invocation of force majeure -- Chapter 9. Romania, in a European energy context -- Chapter 10. Settlement of the dispute, in case the force majeure clause is invoked by Hidroelectrica SA -- Chapter 11. Electricity, systemic crises and environmental policies.
    Abstract: This book aims to highlight the particular situation faced by certain hydropower companies by the fact that they cannot fulfil their contracts due to force majeure. The first part of this book will be an analysis of how water is used in electricity production. It is important to point out that all types of energy sources use water, to a different extent, of course, and that its spatial and temporal availability is very important. The focus will be on hydropower, presenting the current situation at the global level, and the effect of reducing the amounts of water in the river system. The second part is based on the presentation of the concept of force majeure and the ways of presenting and drafting it in a contract. Many disputes or the success of a contract depended heavily on the provisions of this article of the contract. Obviously, there are also situations in which the signatory parties abuse or are not protected by these provisions of force majeure. Starting from a few brief examples from the international level, we reach a wide discussion of the situation created in Romania, when the largest supplier of electricity produced on the basis of water terminates several contracts invoking force majeure. The manner in which the opinion of the parties involved is presented to the court is analyzed and presented in detail.
    Type of Medium: Online Resource
    Pages: XI, 156 p. 35 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031274022
    URL: https://doi.org/10.1007/978-3-031-27402-2
    DOI: 10.1007/978-3-031-27402-2
    DDC: 551.48
    Language: English
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  • 11
    Online Resource
    Online Resource
    Small Water Bodies of the Western Balkans (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Earth sciences. ; Ecology . ; Water. ; Earth Sciences. ; Ecology.
    Description / Table of Contents: Springs as essential water sources for dependent ecosystems in karst -- Small standing-water ecosystems in the transitional temperate climate of the Western Balkans -- Conservation value and habitat diversity of fluvial lakes and gravel pits in river-floodplain systems -- Fountains - overlooked small water bodies in the urban areas -- Temporary ponds in Mediterranean islands: oases of biodiversity -- Riparian springs – challenges from a neglected habitat -- Ecological characteristics and specifics of spring habitats in Bosnia and Herzegovina -- Algae in shallow and small water bodies of Serbia: a frame for species and habitat protection -- Springs and headwater streams in Serbia: the hidden diversity and ecology of aquatic invertebrates. Springs of Southeastern Serbia with a focus on the Vlasina Plateau: different types of challenges for the macroinvertebrate community. Gastropods in small water bodies of the Western Balkans – Endangerments and threats. Importance of small water bodies for diversity of leeches (Hirudinea) of Western Balkan -- Karst springs: isolated ecosystem ecology from the water mite perspective -- Large branchiopods in Small Water bodies: A case study of the Ramsar site „Bardača Wetland“ (NW Republic of Srpska, Bosnia and Herzegovina) -- How important are small lotic habitats of the Western Balkans for local mayflies? -- Fish communities over the Danube wetlands in Serbia and Croatia -- The importance of small water bodies’ conservation for maintaining local amphibian diversity in the Western Balkans -- Human impact induces shifts in trophic composition and diversity of consumer communities in small freshwater ecosystems. Pollution of small lakes and ponds of the Western Balkans - assessment of levels of potentially toxic elements. Conclusions: Small water bodies of the Western Balkans – values and threats. .
    Abstract: The small water bodies such as headwater streams, springs, ditches, small lakes, and ponds are critical to maintaining freshwater biodiversity. This is especially true for Dinaric karst, where they are often the only water bodies present. However, despite their importance, they remain widely overlooked and excluded from government policies like the EU Water Framework Directive. This book includes information on different aspects of these essential but still neglected habitats. This book intends to be of interest to a wide range of audiences, from researchers and conservationists to the public and decision-makers.
    Type of Medium: Online Resource
    Pages: VII, 451 p. 117 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030864781
    Series Statement: Springer Water,
    URL: https://doi.org/10.1007/978-3-030-86478-1
    DOI: 10.1007/978-3-030-86478-1
    DDC: 551.48
    Language: English
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  • 12
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    Online Resource
    Hydrological Modeling : Hydraulics, Water Resources and Coastal Engineering (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Earth sciences. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Natural disasters. ; Sustainability. ; Water. ; Earth Sciences. ; Environmental Engineering/Biotechnology. ; Natural Hazards. ; Sustainability.
    Description / Table of Contents: Performance improvement of usbr vi stilling basin model for pipe outlet -- Rain water harvesting for the main campus of jaipur national university, jagatpura, Jaipur -- Bio Inspired Genetic Algorithm for Optimal Design of Water Distribution Networks -- Drought assessment using various drought indices: a case study of banaskantha district -- Top surface soil moisture retrieval using c- band synthetic aperture radar over kudremukh grasslands -- Meteorological drought assessment in the bharathapuzha river basin -- Experimental and numerical analysis of mean pressure coefficient on C-shaped building with and without round corner. .
    Abstract: This book carefully considers hydrological models which are essential for predicting floods, droughts, soil moisture estimation, land use change detection, geomorphology and water structures. The book highlights recent advances in the area of hydrological modelling in the Ganga Basin and other internationally important river basins. The impact of climate change on water resources is a global concern. Water resources in many countries are already stressed, and climate change along with burgeoning population, rising standard of living and increasing demand are adding to the stress. Furthermore, river basins are becoming less resilient to climatic vagaries. Fundamental to addressing these issues is hydrological modelling which is covered in this book. Integrated water resources management is vital to ensure water and food security. Integral to the management is groundwater and solute transport, and this book encompasses tools that will be useful to mitigate the adverse consequences of natural disasters.
    Type of Medium: Online Resource
    Pages: X, 526 p. 289 illus., 219 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030813581
    Series Statement: Water Science and Technology Library, 109
    URL: https://doi.org/10.1007/978-3-030-81358-1
    DOI: 10.1007/978-3-030-81358-1
    DDC: 551.48
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  • 13
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    Online Resource
    Water Challenges in Rural and Urban Sub-Saharan Africa and their Management (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Water. ; Hydrology. ; Sustainability. ; Environment. ; Food security. ; Earth sciences. ; Geography. ; Water. ; Sustainability. ; Environmental Sciences. ; Food Security. ; Earth and Environmental Sciences.
    Description / Table of Contents: Chapter 1. Introduction to Water Resources of Sub-Saharan Africa -- Chapter 2: Water Challenges in Rural Sub-Saharan Africa -- Chapter 3: Water Challenges in Urban Sub-Saharan Africa -- Chapter 4. Management of Water Challenges in Sub-Saharan Africa -- Chapter 5. Progress towards attaining SDG target on universal access to clean water in Sub-Saharan Africa -- Chapter 6: Recommendations to Improve Management of Water Challenges in Sub-Saharan Africa -- Conclusions.
    Abstract: Sub-Saharan Africa grapples with many public health issues such as food insecurity, increased prevalence of infectious diseases, limited access to clean water supply, poor nutrition and lack of improved health services for its populace (IMF, 2021). Of all these challenges, the inaccessibility of clean water supply for both the rural and urban populace is the most pressing challenge, which has been exacerbated by extensive pollution and climate change crises. The issue of water access and supply affects both rural and urban populations. At rural areas water is accessed in yard taps and in arid regions through water kiosks managed by private owners. Among the urban poor, water access is compromised by poor supply infrastructure especially among informal settlers and risks such as contamination during the supply chain are imminent This book therefore seeks to close this knowledge gap by 1) generating a water resources inventory for Sub-Saharan Africa region, 2) exploring the water crises in both its urban and rural settings, 3) understanding the causatives of the crises and 4) suggesting viable solutions to manage the water challenges using named case studies. The aim is to improve understanding on the region’s water problems and advise scholars and policymakers on priority research areas and action plans to better water management for sustainable development. .
    Type of Medium: Online Resource
    Pages: IX, 112 p. 18 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031262715
    Series Statement: SpringerBriefs in Water Science and Technology,
    URL: https://doi.org/10.1007/978-3-031-26271-5
    DOI: 10.1007/978-3-031-26271-5
    DDC: 551.48
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  • 14
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    Online Resource
    Satellite Remote Sensing of Terrestrial Hydrology (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Environment. ; Environmental monitoring. ; Climatology. ; Earth sciences. ; Environmental geography. ; Water. ; Environmental Sciences. ; Environmental Monitoring. ; Climate Sciences. ; Earth Sciences. ; Integrated Geography.
    Description / Table of Contents: Part 1 -- Chapter 1 Introduction -- Chapter 2 Global water sytems -- Part 2 -- Chapter 3 Optical Remote Sensing Systems -- Chapter 4 Satellite Geodetic Missions -- Part 3 -- Chapter 5 GEE Chapter -- Part 4 -- Chapter 6 Remote Sensing of Freshwater Habitats -- Chapter 7 Remot esensing of vegetation changes -- Part 5 -- Chapter 8 groundwater from space -- Part 6 -- Chapter 9 Impacts of Climate Change on Hydrological Cycle -- Chapter 10 Drought metrics and Indicators -- Part 7 -- Chapter 11 Hydrolological variability -- Part 8 -- Chapter 12 Statistical methods in hydrology -- Part 9 -- Chapter 13 SA_JoH -- Part 10 -- Chapter 14 JoH_Regional -- Part 11 -- Chapter 15 STOTEN -- Chapter 16 Climatic Change -- Part 12 -- Chapter 17 Flinders -- Chapter 18 Mitchell -- Part 13 -- Chapter 19 Brazil drought -- Chapter 20 LCB STOTEN -- Appendix.
    Abstract: This book highlights several opportunities that exist in satellite remote sensing of large-scale terrestrial hydrology. It lays bare the novel concept of remote sensing hydrology and demonstrates key applications of advance satellite technology and new methods in advancing our fundamental understanding of environmental systems. This includes, using state-of-the-art satellite hydrology missions like the Gravity Recovery and Climate Experiment and other multi-mission satellite systems as important tools that underpin water resources planning and accounting. This book discusses and demonstrates how the efficacy, simplicity, and sophistication in novel computing platforms for big earth observation data can help facilitate environmental monitoring and improve contemporary understanding of climate change impacts on freshwater resources. It also provides opportunities for practitioners and relevant government agencies to leverage satellite-based information in a transdisciplinary context to address several environmental issues affecting society. This book provides a general framework and highlights methods to help improve our understanding of hydrological processes and impact analysis from extreme events (e.g., droughts, floods) and climate change.
    Type of Medium: Online Resource
    Pages: XXI, 688 p. 213 illus., 201 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030995775
    URL: https://doi.org/10.1007/978-3-030-99577-5
    DOI: 10.1007/978-3-030-99577-5
    DDC: 551.48
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  • 15
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    Forskolin : Natural Sources, Pharmacology and Biotechnology (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Clinical biochemistry. ; Medicinal chemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Medicinal Chemistry. ; Pharmacy.
    Description / Table of Contents: Chapter 1. Coleus forskohlii – A multipurpose medicinal plant -- Chapter 2. Botany of Coleus forskohlii -- Chapter 3. Traditional Medicinal Uses and Pharmacognosy of Coleus forskohlii -- Chapter 4. Chemistry of Coleus forskohlii Briq. -- Chapter 5. Pharmacology of Coleus forskohlii and Forskolin -- Chapter 6. Micropropagation of Coleus forskohlii -- Chapter 7. In Vitro Production of Forskolin -- Chapter 8. Assessment of Coleus forskohlii Genetic Diversity Using Molecular Markers -- Chapter 9. Endophytes for the enhanced growth of Coleus forskohlii and enhanced production of Forskolin -- Chapter 10. Propagation Methods of Coleus forskohlii -- Chapter 11. Success stories and Trade and Commerce of Coleus forskohlii.
    Abstract: This monograph compiles updated information about forskolin, a labdane diterpene that is produced by the Coleus plant. Forskolin has a large number of practical uses and the book delves into the various aspects of this chemical. It includes topics such as the botanical source of forskolin and the cultivation of Coleus forskohlii, source. It also covers the biosynthetic pathways in natural sources and also through different biotechnological applications. Chapters include the potential and products in the Forskolin market. The book also covers the methods for enhanced production of forskolin from natural sources and through tissue culture methods for improvement of the plant for higher content of forskolin. It discusses the role of endophytes in the production of forskolin. The book is useful for students and researchers in the field of botany, pharmacology and biochemistry. It also serves scientists in various pharmaceutical industries.
    Type of Medium: Online Resource
    Pages: XI, 177 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811965210
    URL: https://doi.org/10.1007/978-981-19-6521-0
    DOI: 10.1007/978-981-19-6521-0
    DDC: 615
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  • 16
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    Online Resource
    Protein Instability at Interfaces During Drug Product Development : Fundamental Understanding, Evaluation, and Mitigation (2021)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Pharmacy. ; Pharmaceutical chemistry. ; Chemistry, Physical and theoretical. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Pharmaceutics. ; Theoretical Chemistry. ; Biotechnology.
    Description / Table of Contents: 1. Overview of the impact of protein interfacial instability on the development of biologic products -- 2. Protein adsorption at a gas-aqueous interface -- 3. Interfacial behaviors of proteins -- 4. Interfacial stresses during drug substance purification processes -- 5. Evaluation of interfacial stress during drug product development -- 6.Relating interfacial shear and dilatations stress-es to protein aggregation in mAbs -- 7. Analytical techniques for evaluating protein instability at interfaces -- 8. Analysis of aggregates and particles -- 9. Protein interfacial instability of mixing and lyophilization during drug product manufacturing process scale-up and tech transfer -- 10. Excipients: Characterization, purpose, and selection -- 11. Interfacial stress and proteins prepared in the solid state -- 12. Interfaces in protein drug delivery: device concern -- 13. Future perspectives. .
    Abstract: Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas. .
    Type of Medium: Online Resource
    Pages: VIII, 338 p. 58 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571771
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 43
    URL: https://doi.org/10.1007/978-3-030-57177-1
    DOI: 10.1007/978-3-030-57177-1
    DDC: 615
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  • 17
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    Online Resource
    Biotechnology of Anti-diabetic Medicinal Plants (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Biotechnology. ; Metabolism, Secondary. ; Plants. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy. ; Biotechnology. ; Plant Secondary Metabolism.
    Description / Table of Contents: 1 In vitro approach and quantification of ‘puerarin and genistein’ - Valuable antidiabetic compounds from Pueraria tuberosa -- 2 In Vitro Exploitation of Medicinal Plants for Continuous Supply of Antidiabetic Bioactive Compounds -- 3 Lower plants as potential source of antidiabetic compounds: The present knowledge and future prospects -- 4 Tissue culture mediated biotechnological intervention in Centella asiatica: A potential antidiabetic plant -- 5 In Vitro Approaches for Mass-Propagation of Stevia rebaudiana -- 6 Swertia chirayita, an endangered anti-diabetic plant: trends in biotechnological interventions -- 7 In vitro propagation and biotechnological improvement strategies of plants with high-intensity sweetener and anti-diabetic activities -- 8 In Vitro Culture Techniques and Metabolite Engineering for Enhanced Anti-Diabetic Secondary Metabolite Production -- 9 Saffron: A prized herb with therapeutic potential against diabetes -- 10 New Insights to Enhance the Desired Anti-Diabetic Compounds in Medicinal and Aromatic Plants Exposed to Abiotic Stress Factors -- 11 Boosting of bioactive secondary metabolites in antidiabetic plants through elicitation: A simple technology for better future -- 12 Rhizobium rhizogenes mediated genetic transformation of antidiabetic plants -- 13 Production of anti-diabetic lignans in flax cell cultures -- 14 Artificial seed development of selected anti-diabetic plants, their storage and regeneration: Progress and prospect -- 15 Cryopreservation of Anti-diabetic plants. .
    Abstract: This book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.
    Type of Medium: Online Resource
    Pages: XVI, 469 p. 70 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811635298
    URL: https://doi.org/10.1007/978-981-16-3529-8
    DOI: 10.1007/978-981-16-3529-8
    DDC: 615
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  • 18
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    Online Resource
    Essentials of Industrial Pharmacy (2022)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Pharmacy. ; Pharmacology. ; Pharmaceutics. ; Pharmacy.
    Description / Table of Contents: Drying -- Mixing -- Comminution -- Filtration -- Pharmaceutical Packaging -- Oral Emulsion -- Oral Suspensions -- Tablets and Capsules -- Oral Inhalers -- Topically Applied Products -- Sterile Products -- Industrial Hazards -- Modified Release Drug Delivery Systems -- Novel Drug Delivery System -- Polymer for Biomedical Applications -- Biotechnology Based Drugs.
    Abstract: Essentials of Industrial Pharmacy is an attempt to comprehensively present, in a single book, various pharmaceutical processes and equipment that are frequently used for production of pharmaceutical dosage forms, along with quality control tests of these dosage forms. Pictorial/graphical illustrations provide easier understanding of complex pharmaceutical concepts, manufacturing processes of pharmaceutical dosage forms. Since it is imperative for pharmacy students to have a clear understanding of the basic concepts used in development of drugs into suitable and stable dosage forms. This book offers a wealth of information regarding basic aspects of pharmaceutical processes and dosage forms, in a single book, for undergraduate pharmacy students or science students (with no pharmacy background) intended to work in the pharmaceutical Industry.
    Type of Medium: Online Resource
    Pages: XV, 298 p. 135 illus., 86 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030849771
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 46
    URL: https://doi.org/10.1007/978-3-030-84977-1
    DOI: 10.1007/978-3-030-84977-1
    DDC: 615
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  • 19
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    Online Resource
    Circadian Pharmacokinetics (2020)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Pharmacy. ; Medical sciences. ; Drug development. ; Pharmacology. ; Pharmacy. ; Preclinical Research.
    Description / Table of Contents: Chapter 1. Introduction to mammalian circadian clock system -- Chapter 2. Introduction to pharmacokinetics -- Chapter 3. Circadian clock and metabolic diseases -- Chapter 4. Circadian clock and CYP metabolism -- Chapter 5. Circadian clock and non-CYP phase I metabolism -- Chapter 6. Circadian clock and phase II metabolism -- Chapter 7. Circadian clock and uptake transporters -- Chapter 8. Circadian clock and efflux transporters -- Chapter 9. Role of pharmacokinetics in chronotherapeutics -- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.
    Abstract: This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
    Type of Medium: Online Resource
    Pages: VII, 253 p. 59 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811588075
    URL: https://doi.org/10.1007/978-981-15-8807-5
    DOI: 10.1007/978-981-15-8807-5
    DDC: 615
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  • 20
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    Online Resource
    Introduction to Basics of Pharmacology and Toxicology : Volume 2 : Essentials of Systemic Pharmacology : From Principles to Practice (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Medical microbiology. ; Neurosciences. ; Pharmacology. ; Pharmacy. ; Medical Microbiology. ; Neuroscience.
    Description / Table of Contents: Part 1. Autonomic Nervous System -- Chapter 1. Cholinoceptor Agonists and Anticholinesterase Agents -- Chapter 2. Cholinoceptor Antagonists -- Chapter 3. Adrenergic Agonists -- Chapter 4. Adrenergic Antagonists -- Part 2. Central and Peripheral Nervous System -- Chapter 5. Neurotransmitters and Neurotransmission. Chapter 6. Hypnotics and Sedatives -- Chapter 7. Pharmacotherapy of Seizures -- Chapter 8. General Anesthetics -- Chapter 9. Drug Therapy of Psychosis and Mania -- Chapter 10. Pharmacotherapy of Depression and Anxiety Disorders Chapter 11. Pharmacotherapy of Neurodegenerative Disorders -- Chapter 12. Opioid Agonists and Antagonists -- Chapter 13. Cognition enhancers, Psychostimulants and Psychedelic Drugs -- Chapter 14. Drug Dependence and Abuse -- Chapter 15. Local Anesthetics -- Chapter 16. Skeletal muscle relaxants. Part 3. Autacoids and Other Chemical Mediators -- Chapter 17. Histamine, Serotonin, Bradykinin, and the Ergot Alkaloids -- Chapter 18. Prostaglandins, Leukotrienes and Related Compounds -- Chapter 19. Non-Steroidal Anti-Inflammatory Medicines -- Chapter 20. Drugs Used in Rheumatoid Arthritis -- Chapter 21. Pharmacotherapy of Gout -- Chapter 22. Nitric oxide, Vasoactive Peptides and Purines -- Part 4. Cardiovascular and Renal Pharmacology -- Chapter 23. Drugs Affecting Renal Excretory Function -- Chapter 24. Antihypertensive Agents -- Chapter 25. Treatment of Ischemic Heart Disease -- Chapter 26. Drugs Used in Heart Failure -- Chapter 27. Drugs Used in Cardiac Arrhythmias -- Chapter 28. Pharmacotherapy of Shock and Drugs Used in Cardiopulmonary Resuscitation -- Chapter 29. Treatment of Pulmonary Arterial Hypertension -- Chapter 30. Antiplatelets, Anticoagulants and Fibrinolytics -- Chapter 31. Drugs Used in Dyslipidemias -- Part 5. Pulmonary Pharmacology -- Chapter 32. Treatment of Asthma and COPD -- Chapter 33. Drugs Used in Cough and Rhinitis -- Part 6 Gastrointestinal Pharmacology -- Chapter 34. Drugs Used in Acid-Peptic Disorders -- Chapter 35. Drugs Affecting Gastrointestinal Motility -- Chapter 36. Antiemetics -- Chapter 37. Drug Therapy for Constipation -- Chapter 38. Antidiarrheal Agents -- Chapter 39. Irritable Bowel Syndrome -- Chapter 40. Pharmacotherapy of Inflammatory Bowel Disease -- Chapter 41. Miscellaneous Drugs Acting on the Gastrointestinal System -- Part 7. Endocrine Pharmacology -- Chapter 42. Hypothalamic and Pituitary Hormones -- Chapter 43. Pharmacotherapy of Diabetes Mellitus -- Chapter 44. Thyroid and Antithyroid Drugs -- Chapter 45. Adrenocorticosteroids and Their Antagonists -- Chapter 46. Gonadal Hormones and Their Inhibitors -- Chapter 47. Pharmacotherapy of Obesity -- Chapter 48. Drugs Affecting Bone Mineral Homeostasis -- Part 8. Hematopoietic System -- Chapter 49. Pharmacotherapy of Iron Deficiency and Other Related Anaemias -- Chapter 50. Pharmacotherapy of Vitamin B12 and Folic Acid Deficiency -- Chapter 51. Drug-Induced Blood Dyscrasias -- Part 9. Chemotherapy of Microbial Diseases -- Chapter 52. General Principles of Antimicrobial Therapy -- Chapter 53. Sulfonamides, Quinolones and Agents For Urinary Tract Infections -- Chapter 54. Penicillins, Cephalosporins and Other β-Lactam Antibiotics -- Chapter 55. Protein Synthesis Inhibitors -- Chapter 56. Antimycobacterial Drugs -- Chapter 57. Antifungal Drugs -- Chapter 58. Antiviral Drugs -- Chapter 59. Miscellaneous Antimicrobial Agents -- Chapter 60. Chemotherapy of Malaria and Other Protozoal Diseases -- Chapter 61. Chemotherapy of Helminthiasis -- Part 10. Pharmacotherapy of Neoplastic Disease -- Chapter 62. General Principles of Cancer Chemotherapy -- Chapter 63. Cytotoxic Drugs -- Chapter 64. Targeted Chemotherapy -- Chapter 65. Hormones Agents in the Pharmacotherapy of Cancer -- Chapter 66. Immunopharmacology -- Chapter 67. Dermatological Pharmacology -- Chapter 68. Ocular Pharmacology -- Chapter 69. Nutritional Supplements and Herbal Medicines -- Chapter 70. Immunoglobulins and Vaccines. .
    Abstract: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences. .
    Type of Medium: Online Resource
    Pages: XXIV, 1175 p. 152 illus., 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813360099
    URL: https://doi.org/10.1007/978-981-33-6009-9
    DOI: 10.1007/978-981-33-6009-9
    DDC: 615
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  • 21
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    Novel Drug Delivery Systems for Chinese Medicines (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Alternative medicine. ; Pharmacy. ; Pharmacology. ; Complementary and Alternative Medicine. ; Pharmacy.
    Abstract: This book describes the essential and cutting-edge concepts based on the frontier of pharmaceutical research in TCM, underlying scientific principles, and current advancements of drug delivery systems for Chinese medicines, including sustained-release drug delivery systems, trans-nasal drug delivery systems, dermal and transdermal drug delivery systems, etc. Novel carriers and emerging technologies (such as 3D printing) are also covered. The book provides readers with an overall picture of drug delivery systems for Chinese medicines and also yields benefits for the pharmaceutical industry with regard to TCM-based drug development.
    Type of Medium: Online Resource
    Pages: XIII, 336 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811634444
    URL: https://doi.org/10.1007/978-981-16-3444-4
    DOI: 10.1007/978-981-16-3444-4
    DDC: 615
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  • 22
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    Water Resilience : Management and Governance in Times of Change (2021)
    Cham :Springer International Publishing :
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    Keywords: Water. ; Hydrology. ; Environmental management. ; Pollution. ; Earth sciences. ; Environment. ; Water. ; Environmental Management. ; Pollution. ; Earth Sciences. ; Environmental Sciences.
    Description / Table of Contents: Part I: Introduction -- Chapter 1. The Emergence of Water Resilience: an introduction -- Part II: Examining water systems through the lens of resilience -- Chapter 2. Water Policy and Governance in Transition: The EU Water Framework Directive -- Chapter 3. The Sustainable Groundwater Management Act (SGMA)—California’s Prescription for Common Challenges of Groundwater Governance -- Chapter 4. Water Policy Reform for Sustainable Development in the Murray-Darling Basin, Australia: Insights from Resilience Thinking -- Chapter 5. Reducing Nutrient Loading from Agriculture to Lake Ecosystems – Contributions of Resilience Principles -- Chapter 6. Reconfiguring water governance for resilient social-ecological systems in South America -- Part III: Exploring the conceptual boundaries and bridges of water resilience -- Chapter 7. Capacities for watershed resilience: persistence, adaptation, and transformation -- Chapter 8. Adaptive Governance in North American Water Systems: a legal perspective on resilience and reconciliation -- Chapter 9. Cross-scale Governance for Urban Water Resilience in Bengaluru and Cape Town -- Chapter 10. Facing Change: Understanding Transitions of River Basin Policies Over Time -- Chapter 11. Conditions and Cautions for Transforming Ocean Governance -- Chapter 12. Extraordinary governance to avoid extraordinary events. Part IV: Conclusion -- Chapter 13. Charting a course for management and governance dimensions of water resilience.
    Abstract: This book synthesizes current knowledge and understanding of management and governance in the context of water resilience; advances theory through synthesis of research and experiences from a variety of disciplinary perspectives. The book highlights the implications of theory and experience for innovation in practice and policy; and it explores frontiers and future research. The book further addresses the need for a consolidated, interdisciplinary approach to the theoretical advances and practical implications of water resilience for academics, resource managers, aid organizations, policy makers and citizens. .
    Type of Medium: Online Resource
    Pages: X, 311 p. 23 illus., 18 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030481100
    URL: https://doi.org/10.1007/978-3-030-48110-0
    DOI: 10.1007/978-3-030-48110-0
    DDC: 551.48
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  • 23
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    Geospatial Technologies for Resources Planning and Management (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Geomorphology. ; Geographic information systems. ; Earth sciences. ; Geography. ; Environmental management. ; Agriculture. ; Water. ; Geomorphology. ; Geographical Information System. ; Earth and Environmental Sciences. ; Environmental Management. ; Agriculture.
    Description / Table of Contents: Geospatial Technology for Geomorphology Mapping and its Applications -- Geospatial technology for estimation of geomorphological characteristics of an ungauged watershed -- Long Term Analysis of River Migration Pattern using Geospatial Techniques – A case study of upper part of the Ganga River, India -- Space borne Scatterometers for understanding the large-scale land hydrological processes -- Wetland Classification and Monitoring Using Time Series Earth Observation Data and Machine Learning Algorithm: A Case Study in Upper Ganga River Stretch.
    Abstract: This book focuses on the application of geospatial technologies for resource planning and management for the key natural resources, e.g. water, agriculture and forest as well as the decision support system (DSS) for infrastructure development. We have seen in the past four decades that the growing complexities of sustainable management of natural resources management have been very challenging. The book has been written to leverage the current geospatial technologies that integrate the remotely sensed data available from various platforms, the precise locational data providing geospatial intelligence, and the advanced integration tools of Geographical Information Systems (GIS). Geospatial technologies have been used for water resources management employing geomorphological characteristics, analysis of river migration pattern, understanding the large-scale hydrological process, wet land classification and monitoring, analysis of glacial lake outburst flood (GLOF), assessment of environmental flow and soil erosion studies, water quality modelling and assessment and rejuvenation of paleochannels through groundwater recharge. Geospatial technologies have been applied for crop classification and mapping, soil moisture determination using RISAT-1 C-band and PALSAR-2 L-band sensors, inventory of horticulture plantations, management of citrus orchards, crop yield forecasting, rice yield estimation, estimation of evapotranspiration and its evaluation against lysimeter and satellite-based evapotranspiration product for India to address the various issues of the agricultural system management. Geospatial technologies have been used for generation of digital elevation model, urban dynamics assessment, mobile GIS application at grass root level planning, cadastral level developmental planning and e-governance applications, system dynamics for sustainable development, micro-level water resources planning, site suitability for sewage treatment plant, traffic density assessment, geographical indications of India, archaeological applications and disasters interventions to elaborate various issues of DSS for infrastructure development and management. Geospatial technologies have been employed for the generation and reconciliation of the notified forest land boundaries, and also the land cover changes analysis within notified forest areas, forest resource assessment, management and monitoring and wildlife conservation and management. This book aims to present high-quality technical case studies representing the recent developments in the “application of geospatial technologies for resource planning and management”. The editors hope that this book will serve as a valuable resource for scientists and researchers to plan and manage land and water resources sustainably.
    Type of Medium: Online Resource
    Pages: VIII, 750 p. 378 illus., 351 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030989811
    Series Statement: Water Science and Technology Library, 115
    URL: https://doi.org/10.1007/978-3-030-98981-1
    DOI: 10.1007/978-3-030-98981-1
    DDC: 551.48
    Language: English
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  • 24
    Online Resource
    Online Resource
    River Hydraulics : Hydraulics, Water Resources and Coastal Engineering Vol. 2 (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Earth sciences. ; Natural disasters. ; Environment. ; Physical geography. ; Water. ; Earth Sciences. ; Natural Hazards. ; Environmental Sciences. ; Earth System Sciences.
    Description / Table of Contents: Effect of bed permeability on flow turbulence in gravel-bed stream -- Study on Erosion and Undercut of Cohesive River Bank – An Experimental Approach -- Hydraulic design of reservoir in permeable pavement for mitigating urban storm water -- Analytical expression for measurement of discharge using conical obstruction in a small rectangular channel -- Efficient numerical algorithm for flow field around vertically submerged tandem and aligned circular cylinders. .
    Abstract: This book presents key principles of the hydraulics of river basins, with a unique focus on the interplay between stream flows and sediment transport. Addressing a number of basic topics related to the hydraulics of river systems, above all it emphasizes applicative aspects in order to provide the reader with a solid grasp of river engineering. The understanding of the river hydraulics is essential for the assessment of optimum locations for the conservation of water resources and its structures. This book will be interesting to readers and researchers working in the specialized area of river hydraulics of Ganga basin, Narmada, Tapi, Godavari, and other basins of India. It consists of review on hydraulics of meandering river; hydraulic design of reservoir in permeable pavement; optimization of hydraulic design; hydraulic investigations to optimize the design of spillway and design of energy dissipater; and analysis of performance of orifice spillway using computational fluid dynamics.
    Type of Medium: Online Resource
    Pages: X, 471 p. 284 illus., 187 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030817688
    Series Statement: Water Science and Technology Library, 110
    URL: https://doi.org/10.1007/978-3-030-81768-8
    DOI: 10.1007/978-3-030-81768-8
    DDC: 551.48
    Language: English
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  • 25
    Online Resource
    Online Resource
    Traditional Rainwater Harvesting Structures (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Water. ; Hydrology. ; Environmental management. ; Earth sciences. ; Geography. ; Sustainability. ; Environmental sciences Social aspects. ; Water. ; Environmental Management. ; Earth and Environmental Sciences. ; Sustainability. ; Environmental Social Sciences.
    Description / Table of Contents: Introduction -- Traditional Rainwater Harvesting -- Traditional Rainwater Harvesting in India -- Management of Rainwater Structures -- Conclusions -- References.
    Abstract: This book contains detailed information about the traditional rainwater structures. Harvesting rainwater is becoming as a practical adaptation strategy for urban areas that are vulnerable to climate alteration. In the past, rainwater harvesting was more significant than it is today. Studies show that a variety of traditional and age-old rainwater gathering techniques were created or put into use in reaction to earlier climate change incidents. According to history, both floods and droughts were frequent occurrences in ancient India. Perhaps this explains why each region of the nation has its own traditional water gathering practices that are representative of the local physical and cultural diversity. All of these methods can be seen as a concept of harvesting rain whenever and wherever it falls. Water makes up 70.9 % of the Earth's surface, mainly in the form of oceans and seas. Water is found in modest proportions as 1.7 % groundwater, 1.7 % glaciers and ice caps in Antarctica and Greenland, vapour, clouds (ice and liquid water suspended in air), and 0.001% precipitation in the air. Evaporation, transpiration, evapo-transpiration, condensation, precipitation, root absorption, percolation, infiltration, base flow and runoff are processes that water goes through on its way to the sea.
    Type of Medium: Online Resource
    Pages: XIX, 104 p. 77 illus., 74 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031380280
    Series Statement: SpringerBriefs in Water Science and Technology,
    URL: https://doi.org/10.1007/978-3-031-38028-0
    DOI: 10.1007/978-3-031-38028-0
    DDC: 551.48
    Language: English
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  • 26
    Online Resource
    Online Resource
    River and Coastal Engineering : Hydraulics, Water Resources and Coastal Engineering (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Natural disasters. ; Engineering geology. ; Earth sciences. ; Environment. ; Water. ; Natural Hazards. ; Geoengineering. ; Earth Sciences. ; Environmental Sciences.
    Description / Table of Contents: Establishing sediment rating curves using optimization technique -- A study on some characteristics of an alluvial channel for varying flows -- Model study for determination of efficiency of a typical silt ejector -- Utility of physical wave model for deepening of inner harbour. .
    Abstract: This book deals with important topics of current interest, such as climate change, floods, drought, and hydrological extremes. The impact of climate change on water resources is drawing worldwide attention in these days; water resources in many countries are already stressed and climate change along with burgeoning population, rising standard of living, and increasing demand are adding to the stress. Further, river basins are becoming less resilient to climatic vagaries. Fundamental to addressing these issues is hydrological modelling which is covered in these books. Further, integrated water resources management is vital to ensure water and food security. Integral to the management is groundwater and solute transport. The books encompass tools that will be useful to mitigate the adverse consequences of natural disasters. This book is useful for those working in river and coastal engineering. River Engineering is important for fluvial hydraulics, sediment transport, morphometry, desilting, trap efficiency, silting and desilting process. Coastal engineering includes storm surge forecast, optimization of harbour, wave modelling, and shoreline changes.
    Type of Medium: Online Resource
    Pages: XIV, 412 p. 240 illus., 208 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031050572
    Series Statement: Water Science and Technology Library, 117
    URL: https://doi.org/10.1007/978-3-031-05057-2
    DOI: 10.1007/978-3-031-05057-2
    DDC: 551.48
    Language: English
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