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  • Books  (52)
  • 2020-2024  (52)
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  • 2021  (52)
  • 615  (27)
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  • 1
    Online Resource
    Online Resource
    Reactive Oxygen Species : Network Pharmacology and Therapeutic Applications (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Abstract: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 425 p. 70 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685102
    Series Statement: Handbook of Experimental Pharmacology, 264
    URL: https://doi.org/10.1007/978-3-030-68510-2
    DOI: 10.1007/978-3-030-68510-2
    DDC: 615
    Language: English
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  • 2
    Online Resource
    Online Resource
    Organotypic Models in Drug Development (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Abstract: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Type of Medium: Online Resource
    Pages: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030700638
    Series Statement: Handbook of Experimental Pharmacology, 265
    URL: https://doi.org/10.1007/978-3-030-70063-8
    DOI: 10.1007/978-3-030-70063-8
    DDC: 615
    Language: English
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  • 3
    Online Resource
    Online Resource
    Pharmacology of Potassium Channels (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Neurosciences. ; Pharmacology. ; Human Physiology. ; Neuroscience.
    Description / Table of Contents: Comparison of K+ Channel families -- High-resolution structures of K+ channels -- Pharmacological approaches to studying potassium channels -- Cardiac K+ channels and channelopathies -- Cardiac hERG K+ channel as safety and pharmacological target -- Pharmacology of A-type K+ channels -- Kv7 channels and hyperexcitability disorders -- Pharmacological activation of neuronal voltage-gated Kv7/KCNQ/M-channels for potential therapy of epilepsy and pain -- Potassium channels in cancer -- Kir channel molecular physiology, pharmacology and therapeutic implications -- The pharmacology of ATP-sensitive K+ channels (KATP) -- Calcium-activated K+ channels (KCa) and therapeutic implications -- The Pharmacology of two-pore domain potassium channels -- Control of biophysical and pharmacological properties of potassium channels by ancillary subunits -- Peptide toxins targeting KV channels -- Therapeutic antibodies targeting potassium ion channels.
    Abstract: The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology. .
    Type of Medium: Online Resource
    Pages: VIII, 545 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030840525
    Series Statement: Handbook of Experimental Pharmacology, 267
    URL: https://doi.org/10.1007/978-3-030-84052-5
    DOI: 10.1007/978-3-030-84052-5
    DDC: 615
    Language: English
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  • 4
    Online Resource
    Online Resource
    Network Pharmacology (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Bioinformatics. ; Pharmacology. ; Pharmacy. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. 'Network Target' Theory and Network Pharmacology -- Chapter 2. Application of Network Pharmacology Based on Artificial Intelligence Algorithm in Drug R & D -- Chapter 3. Commonly used Network Pharmacology Database -- Chapter 4. Commonly used Network Pharmacology Software -- Chapter 5. Network Pharmacology and TCM Modernization Case Studies -- Chapter 6. Network Pharmacology and Modern Drug R & D Cases -- Chapter 7. Drug-based Network Pharmacology Practice Process -- Chapter 8. Disease-based Network Pharmacology Practice Process -- Chapter 9. Drug-disease-based Network Pharmacology Practice Process.
    Abstract: This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
    Type of Medium: Online Resource
    Pages: XVII, 468 p. 163 illus., 119 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811607530
    URL: https://doi.org/10.1007/978-981-16-0753-0
    DOI: 10.1007/978-981-16-0753-0
    DDC: 615
    Language: English
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  • 5
    Online Resource
    Online Resource
    Environment and Female Reproductive Health (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Midwifery. ; Public health. ; Pharmacology. ; Midwifery. ; Public Health.
    Description / Table of Contents: Part I Environmental Harmful Factors -- 1 Introduction to Environmental Harmful Factors -- Part II Female Reproductive Processes and Diseases -- 2 Introduction of Female Reproductive Processes and Reproductive Diseases -- Part III Effects of Environmental Factors on Reproductive Process -- 3 The Influence of Environmental Factors on Ovarian Function, Follicular Genesis, and Oocyte Quality -- 4 Effects of environment and lifestyle factors on premature ovarian failure -- 5 Effects of Environment and Lifestyle Factors on Anovulatory Disorder -- 6 Effects of Cigarette Smoking on Preimplantation Embryo Development -- 7 Toxicical effects of BPDE on dysfunctions of female trophoblast cells -- 8 The Roles of Stress-Induced Immune Response in Female Reproduction -- 9 Effects of Environmental EDCs on Oocyte Quality, Embryo Development and the Outcome in Human IVF Process -- Part IV Effects of Environmental Factors on Reproductive Diseases -- 10 Effects of environmental endocrine-disrupting chemicals on female reproductive health -- 11 Definition and Multiple Factors of Recurrent Spontaneous Abortion -- 12 The Variations of Metabolic Detoxification Enzymes Lead to Recurrent Miscarriage and their Diagnosis Strategy -- Part V Effects of Environmental Factors on Fertility Preservation -- 13 The Effects of Negative Elements in Environment and Cancer on Female Reproductive System.
    Abstract: This book will focus on the harmful effect of environmental toxins on female reproductive health. Reproduction is the basis of the continuation of human beings, and environment is the basis of human survival. However, environmental pollution has become a potential risk factor for human reproductive health, which not only leads to many chronic diseases, but also causes certain harm to reproductive health. Compared to male reproduction, female reproductive process is more complex, the reproductive system is more fragile, and is more vulnerable to be damaged. The aim of this book is to review the research progress, to address the challenges, and to stimulate the development in the direction of environment and female reproductive health.
    Type of Medium: Online Resource
    Pages: XI, 313 p. 13 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813341876
    Series Statement: Advances in Experimental Medicine and Biology, 1300
    URL: https://doi.org/10.1007/978-981-33-4187-6
    DOI: 10.1007/978-981-33-4187-6
    DDC: 615
    Language: English
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  • 6
    Online Resource
    Online Resource
    Organic Cation Transporters in the Central Nervous System (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Molecular biology. ; Pharmacology. ; Human Physiology. ; Molecular Biology.
    Description / Table of Contents: General Overview of Organic Cation Transporters in Brain -- Organic Cation Transporter Expression and Function in the CNS -- Genetic and Epigenetic Regulation of Organic Cation Transporters -- Experimental Methods for Investigating Uptake 2 Processes In Vivo -- Substrates and inhibitors of OCTs and PMAT and therapeutic implications -- Organic Cation Transporters in Brain Histamine Clearance: Physiological and Psychiatric Implications -- Organic Cation Transporters in Brain Catecholamine Homeostasis -- The Interaction of Organic Cation Transporters 1-3 and PMAT with Psychoactive Substances -- Organic Cation Transporters in Psychiatric Disorders -- Organic Cation Transporters and Nongenomic Glucocorticoid Action -- Brain Plasma Membrane Monoamine Transporter in Health and Disease -- Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications -- Organic Cation Transporter (OCT/OCTN) Expression at Brain Barrier Sites: Focus on CNS Drug Delivery.
    Abstract: Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 328 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030829841
    Series Statement: Handbook of Experimental Pharmacology, 266
    URL: https://doi.org/10.1007/978-3-030-82984-1
    DOI: 10.1007/978-3-030-82984-1
    DDC: 615
    Language: English
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  • 7
    Online Resource
    Online Resource
    The Carbonic Anhydrases: Current and Emerging Therapeutic Targets (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy.
    Description / Table of Contents: Dedication -- Preface.-The carbonic anhydrases in health and disease -- Carbonic anhydrase isozymes as diagnostic biomarkers and therapeutic targets -- Targeting carbonic anhydrases in vascular and pulmonary disease -- Carbonic anhydrase inhibitors in ophthalmology: glaucoma and macular oedema -- Targeting carbonic anhydrase isozymes in the treatment of neurological disorders -- Potential of carbonic anhydrase inhibitors in the treatment of oxidative stress and diabetes -- An overview of carbonic anhydrase-related neoplasms -- The carbonic anhydrase IX interactome and the regulation of cancer progression -- Carbonic anhydrase IX: current and emerging therapies -- Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents -- Carbonic anhydrase inhibitors: identifying therapeutic cancer agents through virtual screening -- Targeting carbonic anhydrase IX in tumour imaging and theranostic cancer therapy.
    Abstract: This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
    Type of Medium: Online Resource
    Pages: XII, 288 p. 38 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030795115
    Series Statement: Progress in Drug Research, 75
    URL: https://doi.org/10.1007/978-3-030-79511-5
    DOI: 10.1007/978-3-030-79511-5
    DDC: 615
    Language: English
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  • 8
    Online Resource
    Online Resource
    Pharmacology of the WNT Signaling System (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Physiology. ; Oncology. ; Neurosciences. ; Developmental biology. ; Pharmacology. ; Physiology. ; Oncology. ; Neuroscience. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Pharmacological thinking in WNT signaling -- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically -- WNTs on exosomes -- Strategies to target LRPs in WNT signaling -- Targeting the receptor tyrosine kinase ROR1 by small molecules -- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors -- Disheveled proteins as crucial mediators of WNT signaling -- Destruction complex and regulation of CTNNB1 -- Strategies to therapeutically target WNT/PCP like signaling in disease -- Mining natural compounds to target WNT signaling - from mushrooms to corals -- FZD7 as a therapeutic target in intestinal cancer -- Targeting oncogenic WNT signaling with WNT derived peptides -- Targeting WNT signaling in lung pathology -- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting -- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy? -- Targeting WNT signaling as a risk.
    Abstract: This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of this evolutionarily conserved signaling system leads to many diseases including developmental disorders, diverse forms of cancer, fibrosis, neurodegenerative disease and many more. The WNT signaling system is built upon 19 mammalian, secreted WNT lipoglycoproteins that interact with a plethora of distinct receptors, such as the G protein-coupled receptors called Frizzleds (FZD1-10), LDL receptor-like proteins (LRP5/6), receptor tyrosine kinases (ROR1, 2, RYK and PTK7). In addition, WNT pathways are tightly regulated by many secreted and cell-intrinsic negative regulators, such as soluble FZD-related proteins (SFRPs), Dickkopfs (DKKs), WNT-inhibitory proteins, TIKI, RNF43 and more. Understanding the basic mechanism in terms of receptor-ligand interaction, receptor selectivity, signal initiation and desensitization remain poorly understood, even though substantial advances have been made the recent years. Due to the involvement of the WNT signaling system in human disease, it appears obvious to target diverse branches pharmacologically and therapeutically. However, given the complexity of the system and its importance for stem cell regulation and tissue maintenance, therapy comes with obvious risks for severe side effects. The field is addressing the challenge to identify suitable targets and selective compounds for therapy allowing disease-selective therapeutic effects and balancing unwanted side effects. This book summarizes the current understanding of the basic and applied pharmacology in the WNT signaling system and bridges disciplines such as pharmacology, physiology, neurosciences, oncology and drug development.
    Type of Medium: Online Resource
    Pages: VIII, 422 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030854997
    Series Statement: Handbook of Experimental Pharmacology, 269
    URL: https://doi.org/10.1007/978-3-030-85499-7
    DOI: 10.1007/978-3-030-85499-7
    DDC: 615
    Language: English
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  • 9
    Online Resource
    Online Resource
    The Art of Carbohydrate Analysis (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Chemistry, Organic. ; Food science. ; Biotechnology. ; Pharmacology. ; Organic Chemistry. ; Food Science. ; Biotechnology.
    Description / Table of Contents: Chapter 1 The World of Carbohydrates -- Chapter 2 Basic Knowledge of Glycobiology -- Chapter 3 Carbohydrates involved in Diseases -- Chapter 4 Detection of Carbohydrate by Colorimetric Methods -- Chapter 5. Analytical Techniques to Study Carbohydrates -- Chapter 6 Monosaccharide Composition Analysis -- Chapter 7 Carbohydrate Analysis of Glycoconjugates -- Chapter 8 Structural Characterization of Released Glycans -- Chapter 9 Analysis of Sialic Acids -- Chapter 10 Carbohydrate Microarray Technology -- Chapter 11 Analysis of Carbohydrates by Mass Spectrometry -- Chapter 12 Analysis of Carbohydrates by Nuclear Magnetic -- Chapter 13 Glycobioinformatics -- Chapter 14 Concluding Remarks. .
    Abstract: The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable. This book provides the principles and protocols of various fundamental carbohydrate analysis methods. Choice of method is entirely dependent upon the type of material being investigated (biological samples, food products, etc.), and the level of structural detail required, i.e. sugar content, compositional analysis, linkages between the sugar components, or the total chemical structure of a given molecule. Full structural characterization of carbohydrate chains requires significant time, resources, and skill in several methods of analysis; no single technique can address all glycan analysis needs. This book summarizes several existing analytical techniques (both chemical and physical) in an introductory volume designed for the non-expert researcher or novice scientist. While background in carbohydrate chemistry is assumed, all information necessary to understanding the described techniques is addressed in the text.
    Type of Medium: Online Resource
    Pages: XXV, 350 p. 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030777913
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    URL: https://doi.org/10.1007/978-3-030-77791-3
    DOI: 10.1007/978-3-030-77791-3
    DDC: 615
    Language: English
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  • 10
    Online Resource
    Online Resource
    Structure and Health Effects of Natural Products on Diabetes Mellitus (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Botanical chemistry. ; Bioorganic chemistry. ; Pharmacology. ; Plant Biochemistry. ; Bioorganic Chemistry.
    Description / Table of Contents: Chapter 1. Introduction of diabetes melitus and future prospects of natural products on diabetes melitus -- Chapter 2. Anoverview of hypoglycemic modern drugs -- Chapter 3. An overview of hypoglycemic biological drugs -- Chapter 4. An overview of hypoglycemic traditionaldrugs -- Chapter 5. Glycosides from natural sources in the treatment of diabetes mellitus -- Chapter 6. Isolation and Structure Elucidation of Hypoglycemic Compounds -- Chapter 7. Structural Characterization and Health Effects of Polysaccharides from Momordica charantia on Diabetes Mellitus -- Chapter 8. Effects of polysaccharides on reducing blood glucose based on gut microbiota alteration -- Chapter 9. An Overview of Polysaccharides and the influencefactors of Hypoglycemic Activity -- Chapter 10. Plant Secondary Metabolites with α-Glucosidase Inhibitory Activity. - Chapter 11. Rhinacanthin-C and Its Potential to Control Diabetes Mellitus -- Chapter 12. Regeneration of beta cells by inhibition of pro-apoptotic proteins through phytocompound in STZ induced diabetic albino wistar rats-invivo and insilico approach. - Chapter 13. Nitrogenous Compounds from Plant Origin in Management of -- Chapter 14. Plant Alkaloids with Antidiabetic Potential -- Chapter 15. The role of Alkaloids in the Management of Diabetes Mellitus -- Chapter 16. Traditional Indian Herbs for the Management of Diabetes Mellitus and their Herb-Drug Interaction Potentials: An Evidence-Based Review -- Chapter 17. Role of Micronutrients and Trace elements in Diabetes mellitus: A Review.
    Abstract: The purpose of this book is to introduce the classified chemical components of hypoglycemic compounds in natural products, summarize the recent research progress of natural products with hypoglycemic activity in the past 20 years, and provide the original analysis and development opinions of relevant scholars. Hypoglycemic compounds are to target diabetes mellitus, an important public health problem, one of four priority noncommunicable diseases (NCDs) targeted for action by world leaders. Diabetes mellitus is a common endocrine and metabolic disease, which not only causes physiological damage to patients' kidneys, cardiovascular and cerebrovascular vessels, peripheral blood vessels, nerves and eyes, but also causes mental and psychological pressure to patients. Due to the evidence that traditional medicine and natural herbal formula have advantages in treating diabetes, natural products with hypoglycemic activity have been studied extensively in recent years and have been accepted by many scholars all over the world. This book focuses on the progress on the study of the structure, hypoglycemic activities, structure-activity relationships and mechanism of a wide range of polysaccharides, flavonoids, saponins, alkaloids, terpenoids, polyphenols and other constituents. It will help students and researchers to understand current approaches and progress in the treatment of diabetes with natural products, which may also be beneficial to develop new hypoglycemic drugs.
    Type of Medium: Online Resource
    Pages: VIII, 307 p. 85 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811587917
    URL: https://doi.org/10.1007/978-981-15-8791-7
    DOI: 10.1007/978-981-15-8791-7
    DDC: 615
    Language: English
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  • 11
    Online Resource
    Online Resource
    Evidence Based Validation of Traditional Medicines : A comprehensive Approach (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medical microbiology. ; Medicinal chemistry. ; Pharmacovigilance. ; Pharmacology. ; Medical Microbiology. ; Medicinal Chemistry. ; Drug Safety and Pharmacovigilance.
    Description / Table of Contents: Chapter 1. Global Approach for Drug Discovery and Development from Indian Traditional Medicine -- Chapter 2. Bioactive Natural Leads TargetingCancer Cell Metabolism -- Chapter 3. Omics Technologies and Development of Anti-diabetic Therapies from Prospective Natural Products -- Chapter 4. Amaryllidaceae Alkaloids as Anti-inflammatory Agents Targeting Cholinergic Anti-inflammatory Pathway: Mechanisms and Prospects -- Chapter 5. Neurodegenerative Diseases and Small Molecule Protein Chaperone Activator of Natural Origin -- Chapter 6. Role of Phytomolecules on the Basic Biology of Aging -- Chapter 7. Role of phytomedicine in alleviating oxidative stress mediated vascular complications in diabetes -- Chapter 8. Plant Based -Secretase (BACE-1) Inhibitors: A Mechanistic Approach to Encounter Alzheimer's Disorder -- Chapter 9. Bioactive Compounds of Mangroves as Potent Drug and in Nanoparticle Synthesis - Play a Pivotal Role in Combating Human Pathogens. Chapter 10. Medicinal Plants: A Rich Source of Bioactive Molecules Used in Drug Development -- Chapter 11. Cell-based Assays in Natural Product-based Drug Discovery -- Chapter 12. Allelochemicals: An Emerging Tool for Weed Management -- Chapter 13. Secondary Metabolites of Higher Plants as Green Preservatives of Herbal Raw Materials and Their Active Principles During Postharvest Processing -- Chapter 14. Importance of Chromatography Techniques in Phytomedicine Research -- Chapter 15. Reverse Pharmacology – A Tool for Drug Discovery From Traditional Medicine -- Chapter 16. Role of Modern Biological Techniques in Evidence-Based Validation of Ayurvedic Herbometallic Preparations -- Chapter 17. HPTLC Fingerprinting analysis of Phytoconstituents from Indigenous Medicinal Plants -- Chapter 18. Climate Change,Geographical Location and Other Allied Triggering Factors Modulate the Standardization and Characterization of Traditional Medicinal Plants: AChallenges and Prospect for Phyto-Drug Development -- Chapter 19. Molecular Docking Studies of Plant-Derived Bioactive Compounds: A Comprehensive in silico Standardization Approach -- Chapter 20. Standardization and Quality Evaluation of Botanicals with Special Reference to Marker Components -- Chapter 21. Analytical Standardization of Haridra Formulation by UV-VIS Spectrophotometry and RP-HPLC -- Chapter 22. Ethnobotanical survey: the foundation to evidence based validation of medicinal plants -- Chapter 23. Phytotherapeutics: The Rising Role of Drug Transporters in Herb-Drug Interactions with Botanical Supplements -- Chapter 24. An Insight into Herb Interactions: Clinical Evidence Based Overview -- Chapter 25. Pharmacovigilance of Herbal Medicines: An Overview -- Chapter 26. Herbal Drugs: Efficacy, Toxicity and Safety Issues -- Chapter 27. Herbal Drug Patenting -- Chapter 28. Safety and Regulatory Issues on Traditional Medicine Entrusted Drug Discovery -- Chapter 29. Pharmacovigilance of Herbal Medicine: An Evolving Discipline -- Chapter 30. Toxicity Studies Related to Medicinal Plants -- Chapter 31. Herb-Drug Interactions -- Chapter 32. Plant Based Traditional Herbal Contraceptive Use in India: Safety and Regulatory Issues -- Chapter 33. Traditional Medicine Stability and Pharmacokinetic Issue -- Chapter 34. Pharmacovigilance: Methods in developing the safety and acceptability of traditional medicines -- Chapter 35. Zoopharmacognosy (Plant-Animal Interaction) -- Chapter 36. Significance of Stability and Pharmacokinetic issues in Traditional Medicine -- Chapter 37. Pharmaceutical Formulations Development Based on the Polymers Obtained from Edible Plants: An Excellent Approach for the Betterment in Health Care Services -- Chapter 38. Evaluation of bioactivity of green nanoparticles synthesized from traditionally used medicinal plants: a review -- Chapter 39. Physicochemical, Micromeritics, Biomedical and Pharmaceutical Applications of Assam Bora Rice Starch -- Chapter 40. Natural Excipients in Pharmaceutical Formulations -- Chapter 41. A Wonder Plant Withania: Pharmacological and Chemical Perspectives -- Chapter 42. Immunomodulators and Phyto Drugs -- Chapter 43. Combined Effects of Plant Extracts on Ovarian Cell Functioning -- Chapter 44. Pterocarpussantalinus: A Wonder Gift of Nature -- Chapter 45. Phytochemicals And Investigations On Traditionally Used Medicinal Mushrooms -- Chapter 46. A Review On Investigational Studies Of Marine Macroalgae Spogomorpha Indica L -- Chapter 47. Validation of Traditional Claim of Oxalis debilis Kunth., An Ethnomedicinal Plant from North-eastern Region of India -- Chapter 48. Traditional Herbal Medicine Practiced in Plateau-Fringe and Rarh Districts of West Bengal, India -- Chapter 49. Pharmacology and Mechanisms of Natural Medicine in Treatment of Type 2 Diabetes Mellitus -- Chapter 50. Indian Traditional Herbs and Alzheimer’s Disease: Integrating Ethnobotany and Phytotherapy. .
    Abstract: The demand for traditional medicines, herbal health products, herbal pharmaceuticals, nutraceuticals, food supplements and herbal cosmetics etc. is increasing globally due to the growing recognition of these products as mainly non-toxic, having lesser side effects, better compatibility with physiological flora, and availability at affordable prices. In the last century, medical science has made incredible advances all over the globe. In spite of global reorganization and a very sound history of traditional uses, the promotion of traditional medicine faces a number of challenges around the globe, primarily in developed nations. Regulation and safety is the high concern for the promotion of traditional medicine. Quality issues and quality control, pharmacogivilane, scientific investigation and validation, intellectual property rights, and biopiracy are some key issues that restrain the advancement of traditional medicine around the globe. This book contains diverse and unique chapters, explaining in detail various subsections like phytomolecule, drug discovery and modern techniques, standardization and validation of traditional medicine, and medicinal plants, safety and regulatory issue of traditional medicine, pharmaceutical excipients from nature, plants for future. The contents of the book will be useful for the academicians, researchers and people working in the area of traditional medicine. .
    Type of Medium: Online Resource
    Pages: XII, 1151 p. 378 illus., 125 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811581274
    URL: https://doi.org/10.1007/978-981-15-8127-4
    DOI: 10.1007/978-981-15-8127-4
    DDC: 615
    Language: English
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  • 12
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    Online Resource
    Emerging Technologies for Nanoparticle Manufacturing (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Nanotechnology. ; Nanochemistry. ; Pharmacology. ; Nanotechnology. ; Nanochemistry.
    Description / Table of Contents: Part 1 Introduction and Biomedical Applications of Nanoparticles -- 1. Introduction to Nanomaterials and Nanotechnology -- 2. Biomedical Applications of Nanoparticles -- Part II-Polymeric Nanoparticles -- 3. Nanocrystallization and Nanoprecipitation Technologies -- 4. Microfluidics Technology for Nanoparticles and Equipment-. 5. Production of Nanocomposites via Extrusion Techniques -- 6. The Use of Supercritical Fluids Technologies for Nanoparticle Production -- 7. Salting out and Ionic Gelation Manufacturing Techniques for Nanoparticles -- 8. Nanogel Synthesis by Irradiation of Aqueous Polymer Solutions -- 9. Cellulose acetate based nanofibers: Synthesis, Manufacturing and Applications -- 10. Production of nanofibers, environmental challenges and solutions -- Part III-Lipid Nanoparticles -- 11. High Pressure Homogenization Techniques for Nanoparticles -- 12. Solvent emulsification evaporation and solvent emulsification diffusion techniques for nanoparticles -- 13. Ultrasound Activated Nanoemulsions -- 14. Multiple Emulsions: Emphasizing on industrial applications -- 15. Membrane techniques for the preparation of nanomaterials -- 16. Self-assembling Lipid Nanoparticles/Nanosystems (SLNN) using Hydrophilic Solvents: Overview and Industrial Uses -- 17. Nanoemulsions – An emerging technology in drug delivery -- Part IV- Metallic Nanoparticles -- 18. Manufacturing techniques for carbon nanotubes, gold nanoparticles and silver nanoparticles -- 19. Radio frequency (RF) plasma-based Synthesis of metallic Nano particles for Biomedical Application -- 20. Techniques for accurate sizing of nanoparticles -- 21. Silver nanoparticles synthesis from cyanobacteria: Environmental and biomedical applications -- 22. Selenium Nanoparticles: Green Synthesis and Exploitation -- Part V- Quality control for nanoparticles -- 23. Practical guidelines for the characterization and quality control of nanoparticlesin the pharmaceutical industry -- Part VI-Challenges in scale-up production of nanoparticles -- 24. Nanomedicine Scale-Up Technologies: Feasibilities and Challenges -- 25. Patent survey on recent technology for nanoparticles -- Part VII-Injectable Nanosystems -- 26. Injectable Nanosystems and Inherent Nano-Serum Interactions -- Part VIII- Future directions and challenges -- 27. Current Challenges and Future Directions in Nanomedicine.
    Abstract: This book provides an overview of nanoparticle production methods, scale-up issues drawing attention to industrial applicability, and addresses their successful applications for commercial use. There is a need for a reference book which will address various aspects of recent progress in the methods of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization. There is no consolidated reference book that discusses the emerging technologies for nanoparticle manufacturing. This book focuses on the following major aspects of emerging technologies for nano particle manufacturing. I. Introduction and Biomedical Applications of Nanoparticles II. Polymeric Nanoparticles III. Lipid Nanoparticles IV. Metallic Nanoparticles V. Quality Control for Nanoparticles VI. Challenges in Scale-Up Production of Nanoparticles VII. Injectable Nanosystems VIII. Future Directions and Challenges Leading scientists are selected as chapter authors who have contributed significantly in this field and they focus more on emerging technologies for nanoparticle manufacturing, future directions, and challenges. .
    Type of Medium: Online Resource
    Pages: XV, 611 p. 155 illus., 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030507039
    URL: https://doi.org/10.1007/978-3-030-50703-9
    DOI: 10.1007/978-3-030-50703-9
    DDC: 615
    Language: English
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  • 13
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    Online Resource
    Antiviral Drug Discovery and Development (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Biotechnology.
    Description / Table of Contents: 1 Antiviral Drugs Against Herpesviruses -- 2 An Update on Antiretroviral Therapy -- 3 Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and their Inhibition -- 4 LEDGINs, Inhibitors of the Interaction between HIV-1 Integrase and LEDGF/p75, are Potent Antivirals with a Potential to Cure HIV Infection -- 5 Moving Fast Towards Hepatitis B Virus Elimination -- 6 Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection -- 7 Phytoconstituents as Lead Compounds for Anti-dengue Drug Discovery -- 8 Anti-influenza Drug Discovery and Development: Targeting the Virus and its Host by all -- 9 Search, Identification and Design of Effective Antiviral Drugs against Pandemic Human Coronaviruses -- 10 Peptide Based Antiviral Drugs -- 11 Covalent Antiviral Agents -- 12 Safe-in-Man Broad Spectrum Antiviral Agents -- 13 Exploiting Ubiquitin ligases for Induced Target Degradation as an Antiviral Strategy. .
    Abstract: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
    Type of Medium: Online Resource
    Pages: XI, 357 p. 142 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602672
    Series Statement: Advances in Experimental Medicine and Biology, 1322
    URL: https://doi.org/10.1007/978-981-16-0267-2
    DOI: 10.1007/978-981-16-0267-2
    DDC: 615
    Language: English
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  • 14
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    Online Resource
    Groundwater and Society : Applications of Geospatial Technology (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Geographic information systems. ; Sustainability. ; Environmental protection. ; Civil engineering. ; Water. ; Geographical Information System. ; Sustainability. ; Soil and Water Protection.
    Description / Table of Contents: Chapter 1. Introduction: Groundwater and Society: Applications of Geospatial Technology (Pravat Kumar Shit, Gouri Sankar Bhunia, Partha Pratim Adhikary, Ch. Jyotiprava Dash) -- Part I: Groundwater resources and societal development -- Chapter 2. Groundwater and Society in India: Challenging Issues and Adaptive Strategies (Subrata Jana) -- Chapter 3. Groundwater Research and Societal Development: Integration with Remote Sensing and Geographical Information System (Gouri Sankar Bhunia, Pravat Kumar Shit, Partha Pratim Adhikary and Debashish Sengupta) -- Chapter 4. Geospatial and Geophysical Approaches for Assessment of Groundwater Resources in an Alluvial Aquifer of India (Partha Pratim Adhikary, S.K.Dubey, Debashis Chakraborty, Ch. Jyotiprava Dash) -- Chapter 5. Groundwater and Space Technology: Issues and challenges (Gouri Sankar Bhunia, Pravat Kumar Shit, Harsha Das Gupta, Partha Pratim Adhikary) -- Part II: Groundwater availability, quality and pollution -- Chapter 6. Groundwater Quality through Multi-criteria based GIS Analysis: Village Level Assessment (Baisakhi Chakraborty, Sambhunath Roy, Gouri Sankar Bhunia, Debashish Sengupta, Pravat Kumar Shit) -- Chapter 7. GIS-based Fuzzy-AHP Approach for Assessment of Groundwater Potential Zones of an Urban Agglomeration (Suraj Kumar Mallick, Somnath Rudra) -- Chapter 8. Assessment of Groundwater Availability in Gumani River Basin, India using Geoinformatics and Analytical Hierarchy Process (Sadik Mahammad, Aznarul Islam) -- Chapter 9. Application of AHP for Groundwater Potential Zones Mapping in Plateau Fringe Terrain: Study from Western Province of West Bengal (Manas Karmakar, Monali Banerjee, Mrinal Mandal, Debasis Ghosh) -- Chapter 10. Performance of Frequency Ratio Approach for Mapping of Groundwater Prospect Areas in an Area of Mixed Topography (Subhas Garai, Pulakesh Das) -- Chapter 11. Artificial Neural Network for Identification of Groundwater Potential Zones in part of Hugli District, West Bengal, India (Chalantika Laha Salui and Shashank Yadav) -- Chapter 12. Multi-criteria Analysis for Groundwater Quality Assessment: A Study in Paschim Barddhaman District of West Bengal, India (Payel Das, Niladri Das) -- Chapter 13. Performance of WQI and HPI for Groundwater Quality Assessment: Study from Sangramgarh Colliery of West Burdwan District, West Bengal, India (Tanushree Paul, Manas Nath) -- Chapter 14. Assessment of Groundwater Quality interaction using One-decade Data: Case Study from a Hard Rock Area (S. Satheeshkumar, S. Venkateswaran, T. Maheshwari) -- Chapter 15. Fluoride Dynamics in Precambrian Hard Rock Terrain of North Singbhum Craton and Effect of Fluorosis on Human Health and Society (Biswajit Bera, Sumana Bhattacharjee, Meelan Chamling, Arijit Ghosh, Nairita Sengupta, Supriya Ghosh) -- Chapter 16. Coastal Aquifer Vulnerability for Saltwater Intrusion: A Case Study of Chennai Coast Using GALDIT Model and Geoinformatics (Debabrata Ghorai, Gouri Sankar Bhunia, Pravat Kumar Shit) -- Part III: Sustainable Groundwater resources management -- Chapter 17. Watershed Development Impact on Natural Resources: Groundwater and Surface Water Utilization (Partha Pratim Adhikary, M. Madhu, P. Jakhar, B.S. Naik, H.C. Hombegowda, D. Barman, G.B. Naik, Ch. J. Dash) -- Chapter 18. Long-term Groundwater Behaviour over an Agriculturally Developed State of North-West India: Trend and Impact on Agriculture (Omvir Singh, Amrita Kasana, Pankaj Bhardwaj) -- Chapter 19. Spatial Appraisals of Groundwater Recharge Potential Zone Identification using Remote Sensing and GIS (Gouri Sankar Bhunia, Pranab Kumar Maity, Pravat Kumar Shit) -- Chapter 20. Spatial Mapping of Groundwater Depth to Prioritize the Areas under Water Stress in Rayalaseema Region of Andhra Pradesh, India (Ch. Jyotiprava Dash, PP Adhikary, Uday Mandal) -- Chapter 21. Exploring Vulnerability of Groundwater using AHP and GIS Techniques: A Study in Cooch Behar District, West Bengal, India (Dipankar Saha, Debasish Talukdar, Ujjal Senapati, Tapan Kumar Das) -- Chapter 22. Applicability of Geospatial Technology, Weight of Evidence and Multilayer Perceptron for Groundwater Management: A Geoscientific Study on Birbhum District, West Bengal, India (Niladri Das, Subhasish Sutradhar, Ranajit Ghosh, Prolay Mondal) -- Chapter 23. Water resources management in semi-arid Purulia District of West Bengal, in the context of sustainable development goals (Amit Bera, Shubhamita Das).
    Abstract: This volume advances the scientific understanding, development, and application of geospatial technologies related to groundwater resource management, mapping, monitoring, and modelling using up-to-date remote sensing and GIS techniques. The book further provides a critical analysis of the debates and discourses surrounding groundwater resources and society, illustrates the relationship between groundwater resources and precision agriculture for societal development, and describes novel, region-specific management strategies and techniques for sustainability with case studies. The book is organized into three parts: (I) Groundwater resources and societal development; (II) Groundwater availability, quality and pollution; and (III) Sustainable groundwater resources management. Each section begins with a short introduction that includes an overview of the papers in that section. Individual chapters focus on the core themes of research and knowledge along with some topics that have received lesser attention. The book will be of interest to water resource planners and decision-makers, academic researchers, policy makers, NGOs, and academic researchers and students in Geography, Geophysics, Hydrology, Remote Sensing & GIS, Agriculture, Soil Science, and Agronomy.
    Type of Medium: Online Resource
    Pages: XVI, 534 p. 215 illus., 199 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030641368
    URL: https://doi.org/10.1007/978-3-030-64136-8
    DOI: 10.1007/978-3-030-64136-8
    DDC: 551.48
    Language: English
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  • 15
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    Online Resource
    Reclaiming and Rewilding River Cities for Outdoor Recreation (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Urban ecology (Biology). ; Sociology, Urban. ; Biotic communities. ; Tourism. ; Management. ; Water. ; Urban Ecology. ; Urban Sociology. ; Ecosystems. ; Tourism Management.
    Description / Table of Contents: Introduction. Reclaiming and rewilding river cities for outdoor recreation -- Cities and their waterways -- With rivers to the sea: Ecological restoration of rivers and estuaries and nature-based activities -- Behind good ecological status, the quest to reconquer water territories -- Planning and designing facilities that enhance rivers and encourage the development of tourist and recreational spaces: urban promenades -- Outdoor leisure activities at odds with the city. Arcachon Bay and the Massif des Calanques -- “On the conquest of wild nature” ... but what is meant by ‘nature’? -- The Darsena di Milano (Italy): ‘restoration’ of an urban artificial aquatic environment between citizens' hopes and municipal projects -- Grenoble, the river city facing the mountains (End 19th century-1930s) -- The role and significance of the recreational reconquest of port spaces: Rouen (France), reinvention at the neck of the estuary -- Recreational Activities, Economic and Territorial Development: Caen (France) in the Reconquest of its River? -- Bordeaux’s playful and sporty maritime life: a revolution of venues and activities.
    Abstract: The introduction of sports and recreational facilities into natural environments calls for reflection on their impact on fragile ecosystems. This book is unique in providing an interdisciplinary approach to the ecological restoration of urban and industrial degraded habitats and their use by nearby city-dwellers. For the first time ecologists, sociologists and anthropologists have worked together on particularly sensitive ecosystems such as rivers and estuaries to propose recovery strategies that allow their basic ecological functions to be restored, and which can benefit local populations through nature activities. Nonetheless, the use of natural spaces calls for the building of sustainable towns. This is why this book is distinctive in considering quality of life and well-being as stated objectives of modern river towns. Recently, leisure time has become a part of urban rhythms. In order to favour personal development, an extensive palette of leisure activities is considered by the authors: bird watching entertainment sports culture Many aspects including physical and psychological attributes in relation to the contemporary socio-political fabric are dealt with. While creating areas of freedom, landscaping also induces certain forms of practice and encourages certain social skills. Conversely, the book questions certain types of management based on mass consumption. Don’t they, in the end, aim to satisfy needs that are impermanent and shallow? The image of the contemporary town relies on urban planning projects which, in a global economy, seek to capture the interest of tourists and local populations. How can suitable, diligent planning be successfully combined with both creative design and ecological care? This book demonstrates how biology and sociology can (and should) work in harmony in order to promote an ecosystem approach to environmental management.
    Type of Medium: Online Resource
    Pages: V, 104 p. 38 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030487096
    Series Statement: Estuaries of the World,
    URL: https://doi.org/10.1007/978-3-030-48709-6
    DOI: 10.1007/978-3-030-48709-6
    DDC: 551.48
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  • 16
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    Online Resource
    Climate Change Impacts on Water Resources : Hydraulics, Water Resources and Coastal Engineering (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Earth sciences. ; Physical geography. ; Natural disasters. ; Water. ; Earth Sciences. ; Earth System Sciences. ; Natural Hazards.
    Description / Table of Contents: Trend analyses of seasonal mean temperature Series pertaining to Tapi river basin, using monthly data -- . Dry and wet spell characterization of Naini river basin, western Maharashtra, India -- Assessment of Climate Change on Crop Water Requirement in Tandula Command of Chhattisgarh (India) -- Impact of climate change on hydrological regime of Narmada river basin -- Climate change impacts on water resource in Ethiopia -- Spatio-temporal trend analysis of long term IMD gridded precipitation in Godavari river basin, India -- Forecasting reference evapotranspiration using artificial neural network for Nagpur Region -- Assessment of extremes using time varying downscaling model -- Assessment of impact of land use land cover and climate change on quality of river using water quality index -- Assessment of tail behavior of probability distributions of daily precipitation data over India -- Probabilistic prediction of monthly streamflow using graphical modeling approach. .
    Abstract: This book provides insights and a capacity to understand the climate change phenomenon, its impact on water resources, and possible remedial measures. The impact of climate change on water resources is a global issue and cause for concern. Water resources in many countries are extremely stressed, and climate change along with burgeoning populations, the rise in living standards, and increasing demand on resources are factors which serve to exacerbate this stress. The chapters provide information on tools that will be useful to mitigate the adverse consequences of natural disasters. Fundamental to addressing these issues is hydrological modelling which is discussed in this book and ways to combat climate change as an important aspect of water resource management.
    Type of Medium: Online Resource
    Pages: XVI, 551 p. 223 illus., 199 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030642020
    Series Statement: Water Science and Technology Library, 98
    URL: https://doi.org/10.1007/978-3-030-64202-0
    DOI: 10.1007/978-3-030-64202-0
    DDC: 551.48
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  • 17
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    Online Resource
    Emerging Contaminants Vol. 2 : Remediation (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Pollution. ; Environmental chemistry. ; Refuse and refuse disposal. ; Water. ; Pollution. ; Environmental Chemistry. ; Waste Management/Waste Technology.
    Description / Table of Contents: Preface -- Chapter 1 Emerging Contaminants: Remediation -- Chapter 2 Electrochemical Treatments for the Removal of Emerging Contaminants -- Chapter 3 Technologies to Remove Selenium From Water and Wastewater -- Chapter 4 Advanced Treatments for the Removal of Alkylphenols and Alkylphenol Polyethoxylates from Wastewater -- Index.
    Abstract: Emerging contaminants are chemical and biological agents for which there is growing concern about their potential health and environmental effects. The threat lies in the fact that the sources, fate and toxicology of most of these compounds have not yet been studied. Emerging contaminants, therefore, include a large number of both recently discovered and well-known compounds such as rare earth elements, viruses, bacteria, nanomaterials, microplastics, pharmaceuticals, endocrine disruptors, hormones, personal care products, cosmetics, pesticides, surfactants and industrial chemicals. Emerging contaminants have been found in many daily products, and some of them accumulate in the food chain. Correlations have been observed between aquatic pollution by emerging contaminants and discharges from wastewater treatment plants. Most actual remediation methods are not effective at removing emerging contaminants. This second volume presents comprehensive knowledge on emerging contaminants with a focus on remediation.
    Type of Medium: Online Resource
    Pages: XVI, 401 p. 65 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030690908
    Series Statement: Environmental Chemistry for a Sustainable World, 66
    URL: https://doi.org/10.1007/978-3-030-69090-8
    DOI: 10.1007/978-3-030-69090-8
    DDC: 551.48
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  • 18
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    Online Resource
    Development and Implementation of Ship BWMS (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Water. ; Hydrology. ; Marine engineering. ; Water. ; Marine Engineering.
    Description / Table of Contents: Introduction -- Ship ballast water management system -- Working Principle of ballast water management system -- The key components of the system and the working principle of the unit -- Design method of key components -- Optimization of key components -- Development of control system for ballast water management system -- Maintenance and management of ballast water management system -- Implementation of ballast water management system on ships.
    Abstract: This book introduces the components and principles of the common ballast management systems. The working principles of different filtration, cleaning and sterilizing equipment are also introduced. The calculation norm of the construction design and the calculation method of simulation are described. Besides, different aspects of system management are analyzed. The principle of various detecting sensors, the hardware of control system and the design method of human–computer interface are respectively introduced. Last but not least, the maintenance and management of ballast water management system are described, mainly the maintenance and management of key components which composes the system. .
    Type of Medium: Online Resource
    Pages: IX, 285 p. 233 illus., 172 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813368651
    URL: https://doi.org/10.1007/978-981-33-6865-1
    DOI: 10.1007/978-981-33-6865-1
    DDC: 551.48
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  • 19
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    Online Resource
    Climate Impacts on Water Resources in India : Environment and Health (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Environmental health. ; Environmental monitoring. ; Bioclimatology. ; Refuse and refuse disposal. ; Water. ; Environmental Health. ; Environmental Monitoring. ; Climate Change Ecology. ; Waste Management/Waste Technology.
    Description / Table of Contents: Foreword -- Preface -- 1. Water Pollution and Water Quality Assessment, Environmental Flows -- 2. Water Treatment Technologies and Management -- 3. Climate Change and Climate Variability -- 4. Water and Human Health Issues -- 5. Conclusions. .
    Abstract: This book chiefly focuses on environmental flow, water pollution and water quality. Several chapters also cover water treatment technologies and management. In today’s context, climate change and climate variability are important issues in the water sector, which is called upon to develop adaptation strategies to cope with their negative impacts. Human health depends upon the quality of water used for drinking and irrigation purposes. These core issues are discussed and addressed in several chapters. The book explores the impact of climate change on water resources and considers various climatological scenarios. In this regard, it carries out a trend analysis and compares the performance of various Global Climate Models (GCMs). Further, it conducts a water quality analysis and water quality mapping so as to provide information on the most vulnerable areas in the context of water quality. Emerging pollutants, generated from paper mills, are identified in order to choose an appropriate treatment technology. Bioremediation techniques are included for the characterization of improved water quality parameters. The book also presents a low-cost treatment technology for fluoride removal, which can help water managers ensure potable water to stakeholders. In terms of maintaining river ecology in the downstream areas of water resources project sites, the book provides a number of case studies on assessment of environmental flows. Advanced treatment technologies that can be highly advantageous for removing water pollutants are presented. Given its scope, the book offers a valuable resource for academics, water resources practitioners, scientists, water managers, environmentalists, administrators, NGOs, researchers and students who are involved in water management with a main focus on water pollution, the environment, climate change and health. .
    Type of Medium: Online Resource
    Pages: XIII, 392 p. 142 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030514273
    Series Statement: Water Science and Technology Library, 95
    URL: https://doi.org/10.1007/978-3-030-51427-3
    DOI: 10.1007/978-3-030-51427-3
    DDC: 551.48
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  • 20
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    Online Resource
    Changjiang Riverine and Estuarine Hydro-morphodynamic Processes : In the Context of Anthropocene Era (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Water. ; Hydrology. ; Environmental geography. ; Geomorphology. ; Sedimentology. ; Geology. ; Landscape ecology. ; Water. ; Integrated Geography. ; Geomorphology. ; Sedimentology. ; Geology. ; Landscape Ecology.
    Description / Table of Contents: Changjiang River basin Overview -- Hydrological Processes of the Changjiang River -- Lake hydro-morphodynamic Processes of the Changjiang River -- Channel sediment-dynamics along the mid-lower reach of the Changjiang River -- Tidal flat morphodynamics of the Changjiang Estuary -- Changjiang Estuary modern morphodynamic processes -- Estuarine submerged delta modern morphodynamics -- Morphodynamic couplings between river and delta.
    Abstract: This book provides a comprehensive and systematic analysis of the morphodynamic process of the Changjiang River from upstream to estuary in the Anthropocene. As the longest river in China, the Changjiang River has nurtured Chinese civilization with ample natural resources for thousands of years. Evidence highlights that the Changjiang River has experienced intensive human interference and indicated dramatic changes in the Anthropocene, including “no flood in flood season, no dry in dry season” in discharge; “less flood in flood season, more dry in dry season” in sediment; riverbed shifts from accretion to erosion; lakes in the middle-lower reach turn from sediment sink to source; estuarine tidal flat exhibits self-organization characteristics and maintains the current accretion state; estuarine branches that connect to the sea show district morphodynamic patterns; and depocenters of the submerged delta indicate periodic shifts. The book stresses that dam construction upstream, practically the Three Gorges Dam, the world’s largest hydraulic engineering project, has significant influences on the hydrology and geomorphology of the middle-lower reach but has a slight effect on estuarine delta development. The geomorphological structure of the estuarine channel is dominated by local land reclamation, navigation, and dredging. This book clarifies the river-estuary morphodynamics of the Changjiang River and indicates the general features of global mega rivers under human interference as well as their own response mechanisms. This book also exhibits the potential risk of river-estuary deltas in the future, as both material and dynamics are experiencing acceleration adjustment.
    Type of Medium: Online Resource
    Pages: XXI, 358 p. 247 illus., 237 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811637711
    URL: https://doi.org/10.1007/978-981-16-3771-1
    DOI: 10.1007/978-981-16-3771-1
    DDC: 551.48
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  • 21
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    Online Resource
    Salt-affected Soils and Marginal Waters : Global Perspectives and Sustainable Management (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Agriculture. ; Pollution. ; Sustainability. ; Environmental management. ; Water. ; Agriculture. ; Pollution. ; Sustainability. ; Environmental Management.
    Description / Table of Contents: Chapter 1. Nature and Origin of Salts, Classification, Area and Distribution of Salt-affected Soils -- Chapter 2. Saline Soils -- Chapter 3. Management and Reclamation of Saline Soils -- Chapter 4. Biodrainage -- Chapter 5. Alkali Soils -- Chapter 6. Reclamation and Management of Alkali Soils for Crop Production -- Chapter 7. Nutrient Management in Salt-affected Soils -- Chapter 8. Irrigation Water: Quality Criteria -- Chapter 9. Irrigation and Salinity Control -- Chapter 10. Wastewaters as Non-conventional Sources of Irrigation -- Chapter 11. Trees and Grasses as Alternate Strategies for Management of Salt-affected Soils -- Chapter 12. Environmental Impact of Reclamation of Salt-affected Soils and Intensive Irrigated Agriculture.
    Abstract: This book presents systematic scientific appraisal, classification, genesis and viable technologies for reclamation and management of salt-affected soils and marginal quality waters across India and several other countries. Nature, solubility and geo-chemical mobility of salts have been provided as basis for the development of alkali and saline soils and groundwaters under specific agro-hydro-ecological regions. Chemical amendment (gypsum) based reclamation technology of alkali soils and related pre and post-reclamation water, nutrient and crop management interventions, including re-sodification issues have been comprehensively addressed. Features and operational guidelines of surface, subsurface, vertical and bio-drainage systems have been thoroughly discussed; likewise, amelioration of irrigation induced saline soils in inland and coastal regions and preventive measures for control of salinity and waterlogging along with environmental trade-offs. Practical approaches for amelioration and judicious use of saline, alkali, high SAR- saline and waste waters have been synthesized for different cropping and agro- forestry systems. Emerging issues on use of industrial by-products as amendments for alkali soils, physiological aspects of salt resistance, anatomical and biochemical mechanism of submergence tolerance, specific ion effects of poor quality waters, crop diversification, groundwater recharge, rejuvenation of tsunami affected coastal soils, safety against occurrence of poisonous gas in tube well pits, paddy straw burning and others have been adequately deliberated upon. Combining scientific principles with field experiences, the book is expected to serve as a useful knowledge base for research workers, teachers and students of soil science, agronomy, plant breeding, forestry, irrigation engineering, extension workers, environmentalists and planners associated with reclamation and management of salt affected soils and waters on sustainable basis in developing and developed countries.
    Type of Medium: Online Resource
    Pages: XXII, 714 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030784355
    URL: https://doi.org/10.1007/978-3-030-78435-5
    DOI: 10.1007/978-3-030-78435-5
    DDC: 551.48
    Language: English
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  • 22
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    Online Resource
    Resilience in the English Small-Scale Fishery : Small Fry but Big Issue (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Animal culture. ; Water. ; Animal Science.
    Description / Table of Contents: Chapter 1 : Introduction -- Chapter 2: Interpretive Framework and Methodology -- Chapter 3: The English Inshore Fleet -- Chapter 4: Perceptions of Vulnerability in the English SSF -- Chapter 5: Strategies of Resilience in the English SSF -- Chapter 6: Discussion of the Resilience Strategies -- Chapter 7: Conclusion.
    Abstract: This book is a contribution to our understanding of the worrying situation of small-scale fisheries (SSF) which face marginalisation in most coastal countries. The authors explain why SSF are so pressured; how there has been a powerful backlash against this marginalisation during the last 30 years; what are the main ideational currents supporting this backlash; and what is the enduring value of SSF that justifies that support. The authors discuss the major contemporary interpretations of SSF; the challenges facing SSF globally and in England; and SSF’s coping strategies in response to those challenges through the framework of resilience theory. In an innovative analysis, the authors show how there are three kinds of resilience: passive resilience (where fishers are resigned to their adverse fate), adaptive resilience (where fishers make the best use of the opportunities that are available to them), and transformative resilience (where fishers attempt to change the system that faces them). The authors draw on an extensive range of interview data to provide rich insights into the world of SSF, and they discuss a variety of proposals for improving their conditions. The book will appeal to the growing academic and public community that is following with increasing concern the debate about the future of SFF, and to the environmental movement which has committed itself to support SSF as a greener form of fishing than the large-scale industrial sector.
    Type of Medium: Online Resource
    Pages: XII, 186 p. 2 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030542450
    URL: https://doi.org/10.1007/978-3-030-54245-0
    DOI: 10.1007/978-3-030-54245-0
    DDC: 551.48
    Language: English
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    Online Resource
    Parched - The Cape Town Drought Story (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Sustainability. ; Environmental management. ; Economic policy. ; Social policy. ; Communication. ; Water. ; Sustainability. ; Environmental Management. ; Socio-Economic Policy. ; Media and Communication.
    Description / Table of Contents: Chapter 1, Introduction -- Chapter 2. Water Supply in Cape Town -- Chapter 3. Reconciliation strategy -- Chapter 4. Politics, trust and governance -- Chapter 5. The Drought -- Chapter 6. Reliance on rainfall, climate variability and climate change -- Chapter 7. The Water Resilience Programme -- Chapter 8. The New Water Programme -- Chapter 9. NWP: Managing dam levels -- Chapter 10. NWP: Managing Demand -- Chapter 11. NWP: Augmentation -- Chapter 12. Lessons learnt -- Chapter 13. Conclusion.
    Abstract: The book presents the history of water supply to Cape Town, leading up to the worst ever drought recorded, through political turmoil impacting on drought interventions and resulting in the adoption of an integrated water strategy. Regions reliant on water supply from rainfed dams have always been vulnerable to the impact of drought. This is exacerbated by the uncertainty of future rainfall, which is never guaranteed, and reliance is placed on modelling using historic data. While weather has always been variable, climate has been generally reliable. With anthropogenic activity causing changes in climate, the validity of modelling based on history is currently not fully trusted. Unless the storage capacity is sufficient to carry through numerous seasons of poor rainfall, even with water restrictions to match demand and supply in times of depleted rainfall, the risk of reservoirs running dry remains a threat.
    Type of Medium: Online Resource
    Pages: XXIX, 290 p. 82 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030788896
    URL: https://doi.org/10.1007/978-3-030-78889-6
    DOI: 10.1007/978-3-030-78889-6
    DDC: 551.48
    Language: English
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  • 24
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    Online Resource
    Nile and Grand Ethiopian Renaissance Dam : Past, Present and Future (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Water-power. ; Environment. ; Geography. ; Water. ; Hydroenergy. ; Environmental Sciences. ; Geography.
    Description / Table of Contents: 1. Introduction -- 2. Pre-colonial, Colonial and Post-Colonial Era: A Look into the Historical Depths of the Nile Waters: What to Learn from History -- 3. Global Perspectives and Regional Lessons: The Nile River and The Prospects of The Grand Ethiopian Renaissance Dam -- 4. Beyond GERD: Hydropolitical, Hydrological, Technological and Investment (HHTI) Imperatives for Sustained Economic Cooperation -- 5. Water Resources Account of Egypt vs Ethiopia's Nile Sub-basins: The Utility of the Concept of Water Budget -- 6. Geographical Dimensions of Hydro-politics: The Case of Nile and Mekong Rivers.
    Abstract: This book is a contribution by the presenters of the 2020 International Conference on the Nile and Grand Ethiopian Renaissance Dam (GERD). The Nile basin is facing unprecedented level of water right challenges after the construction of GERD has begun. Ethiopia, Egypt and Sudan have struggled to narrow their differences on filling and operation of the GERD. The need for science and data-based discussion for a lasting solution is crucial. Historical perspectives, water rights, agreements, failed negotiations, and other topics related to the Nile is covered in this book. The book covers Nile water claims past and present, international transboundary basin cooperation and water sharing, Nile water supply and demand management, Blue Nile/Abbay and Grand Ethiopian Renaissance Dam, land and water degradation and watershed management, emerging threats of the Lakes Region in the Nile Basin, and hydrologic variation and monitoring. This book is beneficial for students, researchers, sociologists, engineers, policy makers, lawyers, water resources and environmental managers and for the people and governments of the Nile Basin.
    Type of Medium: Online Resource
    Pages: IX, 525 p. 158 illus., 147 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030764371
    Series Statement: Springer Geography,
    URL: https://doi.org/10.1007/978-3-030-76437-1
    DOI: 10.1007/978-3-030-76437-1
    DDC: 551.48
    Language: English
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  • 25
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    Online Resource
    Macro, Micro, and Nano-Biosensors : Potential Applications and Possible Limitations (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Biomaterials. ; Life sciences. ; Pharmaceutical chemistry. ; Pharmacology. ; Biomaterials. ; Life Sciences. ; Pharmaceutics.
    Description / Table of Contents: Macro-, micro- and nanosensors based on biological / chemical materials -- Bactericidal, fungicidal and immunomodulating activity of nano-surfaces -- Enzymatic Tissue Biotests (MAO and AChE biotests) and Bioindicators -- Is it possible to detect less than one bacterial cell? -- SERS for bacterial, virus and protein bio-sensing -- Biosensors for virus detection -- Specific immobilization of rotaviruses for atomic force microscopy with using Langmuir antibody films based on amphiphilic polyelectrolytes -- Fluorimetric and SERS sensor systems for diagnostics and monitoring of catecholamines-dependent diseases -- Enhanced sensitivity rapid tests for the detection of sepsis marker procalcitonin -- Analytical capabilities of some biosensors for the determination of drugs -- Electrochemical DNA sensors based on nanostructured polymeric materials for determination of antitumor drugs -- Variants of amperometric biosensors in the determination of some micotoxins: analytical capabilities -- New class of diagnostic systems based on polyelectrolyte microcapsules for urea detection -- Bioluminescent nano- and micro-biosensing elements for detection of organophosphorous compounds -- Nano- and microelectrochemical biosensors for determining blood glucose -- Micro-Electrochemical SMBG Biosensor Chip Design Development for Sustainable Mass Production based on the Strategic Platform Patent Map -- Biological Fuel Cells: Applications in Health Service and Ecology -- Recent Trends in Fabrication and Applications of Wearable Bioelectronics for Early-Stage Disease Monitoring and Diagnosis -- Self-powered biosensors in medicine and ecology -- Self-powered implantable biosensors – a review of recent advancements and future perspectives.
    Abstract: This book includes an international group of researchers who present the latest achievements in the field of enzyme, immune system, and microbial and nano-biosensors. It highlights the experimental evidence for formation of biological fuel cells (BFCs)-which has a dual purpose – as a device that produces electricity and the systems which produce it simultaneously cleaning up the environment from polluting organic compounds. Considering the work in the field of macro, micro and nano-biosensors, considerable attention is paid to the use of nanomaterials for the modification of working electrodes. Nanomaterials in some cases can significantly improve the parameters of analytical systems. Readers will be interested in the projection of the presented theoretical and experimental materials in the field of practical application of modern analytical developments. The presented results in many cases imply the possibility of using the created models of macro, micro and nano-biosensors, and biofuel elements in the field of health, and protection/restoration of the environment. It includes information about all existing types of transducers of signals in biosensors – electrochemical, optical and quantum-optics, thermoelectric, data of atomic force microscopy, piezoelectric, and more. On the basis of these principles, descriptions are given about the functioning of macro, micro and nano- biosensors for the detection of compounds used in medicine, detection of compounds that clog the environment, and thus affect human health, for compounds that are potentially the basis for the production of drugs, for the selection of compounds that have medicinal activity, for immunodetection, and to assess the quality of food. These questions form the basis of research carried out in the field of biosensors in the world. Since the described models of biosensors have high sensitivity, high measurement speed and selectivity, the described results attract the attention of both the ordinary reader and business class specialists who create and implement analytical technologies. This book is very useful for researchers in life sciences, chemical sciences, physics, and engineering. In addition, it will be useful for the persons working in industry. Advanced technologies specialists will be attracted by the novelty of the proposed solutions and their relevance and ease of implementation. Since the studies contain sections describing the parameters of different biosensors, BFCs, they are easily navigated into assessing the effectiveness of the practical use of the proposed device. The relevant sections indicate such characteristics as detection ranges, life span, type of biological material used, the method of formation of the bio-receptor part. These parameters are of interest to both developers of new models of biosensors and BFC, and their manufacturers.
    Type of Medium: Online Resource
    Pages: XVIII, 415 p. 122 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030554903
    URL: https://doi.org/10.1007/978-3-030-55490-3
    DOI: 10.1007/978-3-030-55490-3
    DDC: 615
    Language: English
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    Online Resource
    Botulinum Toxin Therapy (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Psychiatry. ; Neurosciences. ; Pharmacology. ; Psychiatry. ; Neuroscience.
    Description / Table of Contents: Part 1. Basic Science -- The History of Botulinum Toxins in Medicine: A Thousand Year Journey -- The History of Botulinum Toxins in Medicine: A Thousand Year Journey -- Botulinum Neurotoxins: Mechanism of Action -- Manufacturing and Clinical Formulations of Botulinum Neurotoxins -- Novel Native and Engineered Botulinum Neurotoxins -- Part 2. Clinical Practice -- Clinical Pharmacology of Botulinum Toxin Drugs -- The Use of Botulinum Toxin for Treatment of the Dystonias -- The Use of Botulinum Toxin for Treatment of Spasticity -- Use of Botulinum Toxin in Ophthalmology -- Hyperhidrosis and Aesthetics -- Use of Botulinum Toxin in Genitourinary System -- Gastrointestinal Uses of Botulinum Toxin -- The Use of Botulinum Toxin in the Management of Headache Disorders -- Botulinum Toxin and Pain -- The Use of Botulinum Toxin for Treatment of Depression.
    Abstract: In a rapidly progressing field, Botulinum Toxin Therapy provides both clinicians and basic researchers with the latest science on the structure and function of botulinum toxins and the use of these toxins to treat a wide variety of diseases. Part 1 of the book reviews the basic science of botulinum toxins including advances in our understanding of the molecular structure and mechanism of action of botulinum toxins. This section also discusses the manufacturing and formulation of botulinum toxins for clinical use and the development of novel therapeutic toxins for the future. Part 2 reviews the use of botulinum toxins in clinical practice. It discusses the clinical pharmacology of botulinum toxin drugs and their use in a wide variety of clinical conditions including headache, spasticity, pain, disorders of the genitourinary and gastrointestinal tract, strabismus, and medical aesthetics.
    Type of Medium: Online Resource
    Pages: VIII, 289 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030663063
    Series Statement: Handbook of Experimental Pharmacology, 263
    URL: https://doi.org/10.1007/978-3-030-66306-3
    DOI: 10.1007/978-3-030-66306-3
    DDC: 615
    Language: English
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    Online Resource
    Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Biotechnology. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Human Physiology. ; Biotechnology. ; Biomedical Research.
    Description / Table of Contents: The effect of curcumin supplementation on pulse wave velocity in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial -- Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer -- The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-blind, Randomized, Placebo-Controlled Trial -- Protective effects of curcumin phytosomes against high-fat diet-induced atherosclerosis -- Intravenous Curcumin Mitigates Atherosclerosis Progression in Cholesterol-fed Rabbits -- Updated review on the role of curcumin in gastrointestinal cancers -- Curcumin can bind and interact with CRP: an in silico study -- Antifungal activities of curcumin and difluorinated curcumin against clinical dermatophyte isolates -- Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial -- Effect of Curcumin on Severity of Functional Dyspepsia; a Triple Blinded Clinical Trial -- Possible mechanisms and special clinical considerations of curcumin supplementation in patients with COVID-19 -- Paving the road toward exploiting the therapeutic effects of ginsenosides: an emphasis on autophagy and endoplasmic reticulum stress -- Medicinal plants and phytochemicals regulating insulin resistance and glucose homeostasis in type 2 diabetic patients: A clinical review -- Plants with anti-addictive potential -- Use of Plant-Derived Natural Products in Sleep Disturbances -- The effects of nutraceuticals and herbal medicine on Candida albicans in oral candidiasis: a comprehensive review -- Pharmacological properties of the plant-derived natural products cannabinoids and implications for cardiovascular health -- Beneficial effects of plant-derived natural products on non-alcoholic fatty liver disease -- Crocin Improves Oxidative Stress in Testicular Tissues of Streptozotocin-Induced Diabetic Rats -- Beneficial Medicinal Plants for Memory and Cognitive Functions Based on Traditional Persian Medicine -- The use of medicinal plants for the treatment of alopecia in the Canon of Avicenna: an evidence-based review -- Ethnobotanical uses, phytochemistry and pharmacology of different Rheum species (Polygonaceae): A review -- Genus Rosa: A review of ethnobotany, phytochemistry and traditional aspects according to Islamic traditional medicine (ITM) -- Ethnobotany, Phytochemistry, traditional and modern uses of Actaea racemosa L. (Black cohosh): A review -- Ethnobotany, phytochemistry and pharmacological features of Centella asiatica: a comprehensive review -- Ethnomedicinal uses, phytochemistry and pharmacology of different Cichorium species (Asteraceae): A review -- Medicinal species of the genus Berberis: A review of their traditional and ethnomedicinal uses, phytochemistry and pharmacology -- Protective effects of intravenous magnesium sulfate in stroke patients receiving amiodarone: A randomized controlled trial -- In silico identification of novel interactions for FABP5 (Fatty Acid-Binding Protein 5) with nutraceuticals: Possible repurposing approach.
    Abstract: Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal of this contributed volume is to present a comprehensive collection on most important therapeutic aspects of plant-derived natural products and their molecular mechanisms of action.
    Type of Medium: Online Resource
    Pages: X, 603 p. 814 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030648725
    Series Statement: Advances in Experimental Medicine and Biology, 1308
    URL: https://doi.org/10.1007/978-3-030-64872-5
    DOI: 10.1007/978-3-030-64872-5
    DDC: 615
    Language: English
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    Protein Instability at Interfaces During Drug Product Development : Fundamental Understanding, Evaluation, and Mitigation (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Pharmaceutical chemistry. ; Chemistry, Physical and theoretical. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Pharmaceutics. ; Theoretical Chemistry. ; Biotechnology.
    Description / Table of Contents: 1. Overview of the impact of protein interfacial instability on the development of biologic products -- 2. Protein adsorption at a gas-aqueous interface -- 3. Interfacial behaviors of proteins -- 4. Interfacial stresses during drug substance purification processes -- 5. Evaluation of interfacial stress during drug product development -- 6.Relating interfacial shear and dilatations stress-es to protein aggregation in mAbs -- 7. Analytical techniques for evaluating protein instability at interfaces -- 8. Analysis of aggregates and particles -- 9. Protein interfacial instability of mixing and lyophilization during drug product manufacturing process scale-up and tech transfer -- 10. Excipients: Characterization, purpose, and selection -- 11. Interfacial stress and proteins prepared in the solid state -- 12. Interfaces in protein drug delivery: device concern -- 13. Future perspectives. .
    Abstract: Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas. .
    Type of Medium: Online Resource
    Pages: VIII, 338 p. 58 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571771
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 43
    URL: https://doi.org/10.1007/978-3-030-57177-1
    DOI: 10.1007/978-3-030-57177-1
    DDC: 615
    Language: English
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    Biotechnology of Anti-diabetic Medicinal Plants (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Biotechnology. ; Metabolism, Secondary. ; Plants. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy. ; Biotechnology. ; Plant Secondary Metabolism.
    Description / Table of Contents: 1 In vitro approach and quantification of ‘puerarin and genistein’ - Valuable antidiabetic compounds from Pueraria tuberosa -- 2 In Vitro Exploitation of Medicinal Plants for Continuous Supply of Antidiabetic Bioactive Compounds -- 3 Lower plants as potential source of antidiabetic compounds: The present knowledge and future prospects -- 4 Tissue culture mediated biotechnological intervention in Centella asiatica: A potential antidiabetic plant -- 5 In Vitro Approaches for Mass-Propagation of Stevia rebaudiana -- 6 Swertia chirayita, an endangered anti-diabetic plant: trends in biotechnological interventions -- 7 In vitro propagation and biotechnological improvement strategies of plants with high-intensity sweetener and anti-diabetic activities -- 8 In Vitro Culture Techniques and Metabolite Engineering for Enhanced Anti-Diabetic Secondary Metabolite Production -- 9 Saffron: A prized herb with therapeutic potential against diabetes -- 10 New Insights to Enhance the Desired Anti-Diabetic Compounds in Medicinal and Aromatic Plants Exposed to Abiotic Stress Factors -- 11 Boosting of bioactive secondary metabolites in antidiabetic plants through elicitation: A simple technology for better future -- 12 Rhizobium rhizogenes mediated genetic transformation of antidiabetic plants -- 13 Production of anti-diabetic lignans in flax cell cultures -- 14 Artificial seed development of selected anti-diabetic plants, their storage and regeneration: Progress and prospect -- 15 Cryopreservation of Anti-diabetic plants. .
    Abstract: This book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.
    Type of Medium: Online Resource
    Pages: XVI, 469 p. 70 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811635298
    URL: https://doi.org/10.1007/978-981-16-3529-8
    DOI: 10.1007/978-981-16-3529-8
    DDC: 615
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    Introduction to Basics of Pharmacology and Toxicology : Volume 2 : Essentials of Systemic Pharmacology : From Principles to Practice (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Medical microbiology. ; Neurosciences. ; Pharmacology. ; Pharmacy. ; Medical Microbiology. ; Neuroscience.
    Description / Table of Contents: Part 1. Autonomic Nervous System -- Chapter 1. Cholinoceptor Agonists and Anticholinesterase Agents -- Chapter 2. Cholinoceptor Antagonists -- Chapter 3. Adrenergic Agonists -- Chapter 4. Adrenergic Antagonists -- Part 2. Central and Peripheral Nervous System -- Chapter 5. Neurotransmitters and Neurotransmission. Chapter 6. Hypnotics and Sedatives -- Chapter 7. Pharmacotherapy of Seizures -- Chapter 8. General Anesthetics -- Chapter 9. Drug Therapy of Psychosis and Mania -- Chapter 10. Pharmacotherapy of Depression and Anxiety Disorders Chapter 11. Pharmacotherapy of Neurodegenerative Disorders -- Chapter 12. Opioid Agonists and Antagonists -- Chapter 13. Cognition enhancers, Psychostimulants and Psychedelic Drugs -- Chapter 14. Drug Dependence and Abuse -- Chapter 15. Local Anesthetics -- Chapter 16. Skeletal muscle relaxants. Part 3. Autacoids and Other Chemical Mediators -- Chapter 17. Histamine, Serotonin, Bradykinin, and the Ergot Alkaloids -- Chapter 18. Prostaglandins, Leukotrienes and Related Compounds -- Chapter 19. Non-Steroidal Anti-Inflammatory Medicines -- Chapter 20. Drugs Used in Rheumatoid Arthritis -- Chapter 21. Pharmacotherapy of Gout -- Chapter 22. Nitric oxide, Vasoactive Peptides and Purines -- Part 4. Cardiovascular and Renal Pharmacology -- Chapter 23. Drugs Affecting Renal Excretory Function -- Chapter 24. Antihypertensive Agents -- Chapter 25. Treatment of Ischemic Heart Disease -- Chapter 26. Drugs Used in Heart Failure -- Chapter 27. Drugs Used in Cardiac Arrhythmias -- Chapter 28. Pharmacotherapy of Shock and Drugs Used in Cardiopulmonary Resuscitation -- Chapter 29. Treatment of Pulmonary Arterial Hypertension -- Chapter 30. Antiplatelets, Anticoagulants and Fibrinolytics -- Chapter 31. Drugs Used in Dyslipidemias -- Part 5. Pulmonary Pharmacology -- Chapter 32. Treatment of Asthma and COPD -- Chapter 33. Drugs Used in Cough and Rhinitis -- Part 6 Gastrointestinal Pharmacology -- Chapter 34. Drugs Used in Acid-Peptic Disorders -- Chapter 35. Drugs Affecting Gastrointestinal Motility -- Chapter 36. Antiemetics -- Chapter 37. Drug Therapy for Constipation -- Chapter 38. Antidiarrheal Agents -- Chapter 39. Irritable Bowel Syndrome -- Chapter 40. Pharmacotherapy of Inflammatory Bowel Disease -- Chapter 41. Miscellaneous Drugs Acting on the Gastrointestinal System -- Part 7. Endocrine Pharmacology -- Chapter 42. Hypothalamic and Pituitary Hormones -- Chapter 43. Pharmacotherapy of Diabetes Mellitus -- Chapter 44. Thyroid and Antithyroid Drugs -- Chapter 45. Adrenocorticosteroids and Their Antagonists -- Chapter 46. Gonadal Hormones and Their Inhibitors -- Chapter 47. Pharmacotherapy of Obesity -- Chapter 48. Drugs Affecting Bone Mineral Homeostasis -- Part 8. Hematopoietic System -- Chapter 49. Pharmacotherapy of Iron Deficiency and Other Related Anaemias -- Chapter 50. Pharmacotherapy of Vitamin B12 and Folic Acid Deficiency -- Chapter 51. Drug-Induced Blood Dyscrasias -- Part 9. Chemotherapy of Microbial Diseases -- Chapter 52. General Principles of Antimicrobial Therapy -- Chapter 53. Sulfonamides, Quinolones and Agents For Urinary Tract Infections -- Chapter 54. Penicillins, Cephalosporins and Other β-Lactam Antibiotics -- Chapter 55. Protein Synthesis Inhibitors -- Chapter 56. Antimycobacterial Drugs -- Chapter 57. Antifungal Drugs -- Chapter 58. Antiviral Drugs -- Chapter 59. Miscellaneous Antimicrobial Agents -- Chapter 60. Chemotherapy of Malaria and Other Protozoal Diseases -- Chapter 61. Chemotherapy of Helminthiasis -- Part 10. Pharmacotherapy of Neoplastic Disease -- Chapter 62. General Principles of Cancer Chemotherapy -- Chapter 63. Cytotoxic Drugs -- Chapter 64. Targeted Chemotherapy -- Chapter 65. Hormones Agents in the Pharmacotherapy of Cancer -- Chapter 66. Immunopharmacology -- Chapter 67. Dermatological Pharmacology -- Chapter 68. Ocular Pharmacology -- Chapter 69. Nutritional Supplements and Herbal Medicines -- Chapter 70. Immunoglobulins and Vaccines. .
    Abstract: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences. .
    Type of Medium: Online Resource
    Pages: XXIV, 1175 p. 152 illus., 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813360099
    URL: https://doi.org/10.1007/978-981-33-6009-9
    DOI: 10.1007/978-981-33-6009-9
    DDC: 615
    Language: English
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    The 'Big Four’ Snakes of India : Venom Composition, Pharmacological Properties and Treatment of Envenomation (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Invertebrates. ; Medicine Research. ; Biology Research. ; Epidemiology. ; Biochemistry. ; Pharmacology. ; Invertebrate Zoology. ; Biomedical Research. ; Epidemiology. ; Biochemistry.
    Description / Table of Contents: Chapter 1. Introduction: The snakebite problem -- Chapter 2. Evolution of snakes and systematics of Big Four venomous snakes of India -- Chapter 3. Snake venom: Composition, evolution, function, and biomedical applications -- Chapter 4. Indian spectacled cobra (Naja naja) -- Chapter 5. Indian common Krait (Bungarus cerelus) -- Chapter 6. Indian Russell’s viper (Daboia russelii) -- Chapter 7. Indian Saw-scaled viper (Echis carinatus) -- Chapter 8. Prevention and Treatment of Big Four Snakebite in India.
    Abstract: This book provides detailed and updated knowledge about medically important ‘Big Four’ venomous snakes of India (Indian spectacled cobra, Indian common krait, Indian Russell’s viper, and Indian saw-scaled viper). This book essentially covers the snakebite problem in the world with particular reference to Asia and India. It discusses the evolution and systematics of venomous snakes, emphasizing ‘Big Four’ venomous snakes of India; the evolution and composition of venoms determined by traditional biochemical and modern proteomic analyses. It also describes the pharmacological properties of enzymatic and non-enzymatic toxins of ‘Big Four’ venomous snakes of India. Different chapters discuss exciting topics such as species-specific and geographical differences in venom composition and its impact on pathophysiology and clinical manifestations of snakebite envenomation in India, biomedical application of Indian snake venom toxins; production and quality assessment of commercial antivenom, prevention, and treatment of snakebite in India, adverse effects of antivenom including strategies to combat antivenom reactions inpatient. This book caters to toxinologists, pharmacologists, zoologists, antivenom manufacturers, biochemists, clinicians, evolutionary biologists, herpetologists, and informed non-specialists interested to know about the Indian snake venoms. .
    Type of Medium: Online Resource
    Pages: XI, 161 p. 55 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811628962
    URL: https://doi.org/10.1007/978-981-16-2896-2
    DOI: 10.1007/978-981-16-2896-2
    DDC: 615
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    Online Resource
    Viral Vectors in Veterinary Vaccine Development : A Textbook (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Veterinary microbiology. ; Virology. ; Pharmacology. ; Veterinary Microbiology. ; Virology.
    Description / Table of Contents: Chapter 1. Introduction to Veterinary Vaccines -- Chapter 2. "What is Required to Develop a Viral Vector Vaccine: Key Components of Vaccine-Induced Immune Responses" -- Chapter 3. Viruses and the evolution of viral vectors -- Chapter 4. The role of adjuvants in the application of viral vector vaccines -- Chapter 5. Adenovirus Vectors -- Chapter 6. Poxvirus Vectors -- Chapter 7. The Construction and Evaluation of Herpesvirus Vectors -- Chapter 8. Paramyxoviruses as Vaccine Vectors -- Chapter 9. Rhabdoviruses as vaccine vectors for veterinary pathogens -- Chapter 10. Coronaviruses as Vaccine Vector for Veterinary Pathogens -- Chapter 11. Alphavirus-Based Vaccines -- Chapter 12. Manufacturing and Control of Viral Vectored Vaccines: Challenges -- Chapter 13. Regulatory strategies and factors affecting veterinary viral vector development -- Chapter 14. "Emerging Viral Vectored Technology Future potential of capripoxvirus and African swine fever virus as viral vectors". .
    Abstract: This highly accessible textbook introduces readers to the development of viral vectors and discusses their application in veterinary vaccinology. It offers comprehensive information on the latest advances in this emerging research field, together with a broad overview of the history of veterinary vaccines and viral vectors. The book also addresses issues concerning funding, translational research and ethics that will impact the future development, manufacture and global use of viral vector-based veterinary vaccines. The book addresses the needs of graduate students and researchers in the fields of Veterinary Medicine, Virology and Immunology. .
    Type of Medium: Online Resource
    Pages: XI, 230 p. 35 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030519278
    URL: https://doi.org/10.1007/978-3-030-51927-8
    DOI: 10.1007/978-3-030-51927-8
    DDC: 615
    Language: English
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    Online Resource
    Protein Kinase-mediated Decisions Between Life and Death (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacology.
    Description / Table of Contents: Protein kinase-mediated decision between life and death -- Aging, cellular senescence and protein kinases -- Oxidative stress-related endothelial cell death and protein kinases -- Signal transduction in immune cells and protein kinases -- Role of protein kinase C in immune cell activation and its implication chemical-induced immunotoxicity -- Metabolic stress and immunity -- Activation of tropomyosin-related kinase receptor B by N-acetyl-serotonin: implications for neuroprotection -- Protein kinase inhibitors in traumatic brain injury and repair -- Amyloid beta toxicity in Alzheimer’s Disease and neuronal death-associated protein kinases -- Glucolipotoxicity-related beta cell death and protein kinases -- Protein kinases and cell death in hematological disorders -- A crosstalk between dual-specific phosphatases and dual-specific protein kinases can be a potential therapeutic target for anti-cancer therapy -- Bile acid toxicity and protein kinases -- Nanoparticle toxicity: Protein kinases and cell death -- Two-component signal transduction systems in antibiotic resistance -- ERK1/2 MAP kinase, its regulation and role in cellular activities including apoptosis and cell survival. .
    Abstract: Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 415 p. 30 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030498443
    Series Statement: Advances in Experimental Medicine and Biology, 1275
    URL: https://doi.org/10.1007/978-3-030-49844-3
    DOI: 10.1007/978-3-030-49844-3
    DDC: 615
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    Online Resource
    Drug Discovery and Drug Development : The Indian Narrative (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Drug delivery systems. ; Biologicals. ; Biopharmaceutics. ; Toxicology. ; Biotechnology. ; Pharmacology. ; Drug Delivery. ; Biologics. ; Toxicology. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Traditional Medical System (TMS) for Sustainable Healthcare in India -- Chapter 2. Modern Drug Discovery and Development for TB- The India Narrative -- Chapter 3. Indian Discovery Effort in the Quest of Novel Antibiotics -- Chapter 4. New Drug Discovery and Development in India to Counter Malaria -- Chapter 5. Modern Drug Discovery and Development in the area of Leishmaniasis -- Chapter 6. Modern Drug Discovery and Development: Diabetes and lifestyle disorders Part I – Introduction to Diabetes and Prevalence in India -- Chapter 7. Modern Drug Discovery and Development: Diabetes and lifestyle disorder Part II Type 2 Diabetes Mellitus: Marketed drugs and mechanisms -- Chapter 8. Modern Drug Discovery and Development: Diabetes and lifestyle disorders Part III Anti-diabetes research in India: Contributions from industrial organizations -- Chapter 9. Modern Drug Discovery and Development: Diabetes and lifestyle disorders Part IV Indian Academia Tryst with Cardio-metabolic Drug Discovery and Development -- Chapter 10. Modern drug discovery and development in the area of Cancer: Indian context -- Chapter 11. Biopharmaceutical development in India: recommendations on collaboration and innovation to enable affordable healthcare -- Chapter 12. Regulatory requirements and Quality Standards in India’s Clinical Trials Journey -- Chapter 13. Indian Pharma Perspective: New Drug Discovery and Development- Indian Pharmaceutical Industry.
    Abstract: Over the years, India has attained a prominent global position in the manufacture of Generic Drugs. This success can be attributed to its synthetic organic chemistry and chemical engineering strengths, nurtured by the timely policies of the Government of India. However, breakthrough successes in New Drug Discovery have remained elusive, despite the brilliant and sustained efforts of many Indian researchers and Pharma establishments. The Indian National Science Academy thought it appropriate to document India’s New Drug Discovery Research (NDDR) journey to date. Gathering contributions from prominent researchers in the Indian Pharma Industry and Academia, this book highlights their efforts, achievements, and the status quo of Indian NDDR. .
    Type of Medium: Online Resource
    Pages: XIII, 376 p. 191 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811580024
    URL: https://doi.org/10.1007/978-981-15-8002-4
    DOI: 10.1007/978-981-15-8002-4
    DDC: 615
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  • 35
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    Online Resource
    Gold and its Complexes in Anticancer Chemotherapy (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Medicinal chemistry. ; Cancer. ; Microtechnology. ; Microelectromechanical systems. ; Pharmacovigilance. ; Pharmacology. ; Medicinal Chemistry. ; Cancer Biology. ; Microsystems and MEMS. ; Drug Safety and Pharmacovigilance.
    Description / Table of Contents: Chapter 1. Cancer -- Chapter 2. Types of cancer -- Chapter 3. Classification -- Chapter 4. Cancer or tumor nomenclature -- Chapter 5. Heterogeneity -- Chapter 6. Invasion and metastasis -- Chapter 7. How cancer arises? -- Chapter 8. Epidemiology -- Chapter 9. Economic burden -- Chapter 10. Treatment modalities -- Chapter 11. Chemotherapy -- Chapter 12. Properties of metals and metal complexes -- Chapter 13. Platinum based anticancer agents -- Chapter 14. Chemistry of cisplatin -- Chapter 15. Mechanism of action of platinum drugs -- Chapter 16. Non-platinum anticancer agents -- Chapter 17. Chemistry of gold -- Chapter 18. Gold and its complexes in medicine -- Chapter 19. Auranofin and its analogues -- Chapter 20. Classes of gold complexes -- Chapter 21. Mechanisms of action of anticancer gold complexes -- Chapter 22. Perspectives.
    Abstract: This book presents an overview of cancer and the genesis, and development of different treatment strategies and modalities against cancer. The emergence of gold and its complexes as promising anticancer chemotherapeutic agents have the potential to substitute or replace the platinum based chemotherapeutic agents. Gold complexes have demonstrated considerable anti-proliferative properties, chiefly attributed to their anti-mitochondrial effects, they make gold complexes excellent candidates as anti-cancer agents compared to their platinum-based counterparts. This book provides a critical review of recent advances made in the development of gold complexes as anti-cancer agents. In this context, it examines a number of different ligand architectures, provides comprehensive information on gold complexes’ mechanism of action and toxicity issues and, in closing, outlines future research directions.
    Type of Medium: Online Resource
    Pages: IX, 173 p. 124 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813363144
    URL: https://doi.org/10.1007/978-981-33-6314-4
    DOI: 10.1007/978-981-33-6314-4
    DDC: 615
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    Molecularly Imprinted Polymers as Advanced Drug Delivery Systems : Synthesis, Character and Application (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Drug delivery systems. ; Biotechnology. ; Pharmacology. ; Drug Delivery. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Synthetic Strategies for the Generation of Molecularly Imprinted Polymers -- Chapter 3. Special Control by Molecular Imprinting Materials-zero-order Sustained Release, Enantioselective MIPs and Self-regulated Drug Delivery Microdevices -- Chapter 4. Water Compatible Molecularly Imprinted Polymers -- Chapter 5. Stimuli Responsive Imprinted DDS -- Chapter 6. MIP as Drug Delivery Systems for Dermal Delivery -- Chapter 7. MIP as Drug Delivery Systems of Anticancer Agents -- Chapter 8. MIP as Dug Delivery Systems of Ophthalmic Drugs -- Chapter 9. MIP as Drug Delivery Systems for Special Application -- Chapter 10. Outlook.
    Abstract: This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine. To this end, the following unique features will be discussed and concluded: 1) State-of-the-art definition of MIP as drug delivery systems. 2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade. 3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS. 4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment. 5) Future challenges and perspectives.
    Type of Medium: Online Resource
    Pages: VII, 216 p. 108 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602276
    URL: https://doi.org/10.1007/978-981-16-0227-6
    DOI: 10.1007/978-981-16-0227-6
    DDC: 615
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    Novel Drug Delivery Systems for Chinese Medicines (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Alternative medicine. ; Pharmacy. ; Pharmacology. ; Complementary and Alternative Medicine. ; Pharmacy.
    Abstract: This book describes the essential and cutting-edge concepts based on the frontier of pharmaceutical research in TCM, underlying scientific principles, and current advancements of drug delivery systems for Chinese medicines, including sustained-release drug delivery systems, trans-nasal drug delivery systems, dermal and transdermal drug delivery systems, etc. Novel carriers and emerging technologies (such as 3D printing) are also covered. The book provides readers with an overall picture of drug delivery systems for Chinese medicines and also yields benefits for the pharmaceutical industry with regard to TCM-based drug development.
    Type of Medium: Online Resource
    Pages: XIII, 336 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811634444
    URL: https://doi.org/10.1007/978-981-16-3444-4
    DOI: 10.1007/978-981-16-3444-4
    DDC: 615
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    Nanoparticles for Rational Vaccine Design (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Nanochemistry. ; Virology. ; Pharmacology. ; Human Physiology. ; Nanochemistry. ; Virology.
    Description / Table of Contents: Preface -- Liposome Formulations as Adjuvants for Vaccines -- Polymeric nanoparticle-based vaccine adjuvants and delivery vehicles -- Virus-like particle vaccines against respiratory viruses and protozoan parasites -- Protein and Peptide Nanocluster Vaccines.
    Abstract: This book introduces nanoparticles as a powerful platform for vaccine design. Current challenges in vaccine development are discussed and the unique advantages nanoparticles provide in overcoming these challenges are explored. The authors offer fascinating insights into the immunological assets of using nanoparticles as delivery vehicles or adjuvants and present different materials that are being used in nanoparticle-based vaccine development, covering peptides, proteins, polymers, virus-like particles, and liposomes. Its contemporary research insights and practical examples for applications make this volume an inspiring read for researchers and clinicians in vaccinology and immunology. Chapter "Liposome Formulations as Adjuvants for Vaccines" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VII, 130 p. 26 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030850678
    Series Statement: Current Topics in Microbiology and Immunology, 433
    URL: https://doi.org/10.1007/978-3-030-85067-8
    DOI: 10.1007/978-3-030-85067-8
    DDC: 615
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    Towards Water Secure Societies : Coping with Water Scarcity and Quality Challenges (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Environment. ; Pollution. ; Water. ; Environmental Sciences. ; Pollution.
    Description / Table of Contents: Introduction -- Water Security Assessment for the Red – Thai Binh River Basin, Vietnam -- Contextualizing Farmers’ Perceptions of Agricultural Wastewater Reuse in Areas of Water Shortage and Contamination: An In-depth Case Study of Wadi Al-Far`a Watershed – Palestine -- Optimize Anaerobic Degradation Processes in Agricultural Wastewater Treatment to maximize Biogas Productivity -- Evaluation of Wastewater Treatment using Dilution in Rosetta Branch and Tala Drain, Nile Delta, Egypt -- Upcoming Challenges of Water Reclamation fromUnconventional Sources -- How Membrane Bioreactor Technology Can Help to Solve both, German and RussianWastewater Problems -- Experiences on Wastewater Treatment and Reuse for Different Types of Industries -- Social Characteristics and Adaptation to Water Scarcity: The Case of Groundnut Farmers in the Lawra and Nandom Districts, Ghana -- Temporal Climate Variability and Staple Cereals in Southern Burkina Faso.
    Abstract: This book describes the water security challenges with focus on water scarcity and quality in our rapidly changing world. Achieving water security is essential to promoting economic and social development, as well as resource sustainability and ecosystem integrity. Questions of water security are central to recent global agreements such as the Sustainable Development Goals (SDGs), the Paris Agreement on Climate Change, and the Sendai Framework for Disaster Risk Reduction. The thematic areas discussed here support the SDGs, with special attention to Goal 6 (“Ensure availability and sustainable management of water and sanitation”). The book is a collection of studies from engineering, social and environmental disciplines and aims at giving a balanced overview of the current , complex discourse on water scarcity and quality. It offers a source of inspiration and information for researchers, policymakers, planners, and practitioners concerning the further development of concepts, approaches, and methodologies for promoting water secure societies.
    Type of Medium: Online Resource
    Pages: XIII, 200 p. 90 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030506537
    URL: https://doi.org/10.1007/978-3-030-50653-7
    DOI: 10.1007/978-3-030-50653-7
    DDC: 551.48
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    Water Resilience : Management and Governance in Times of Change (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Environmental management. ; Pollution. ; Earth sciences. ; Environment. ; Water. ; Environmental Management. ; Pollution. ; Earth Sciences. ; Environmental Sciences.
    Description / Table of Contents: Part I: Introduction -- Chapter 1. The Emergence of Water Resilience: an introduction -- Part II: Examining water systems through the lens of resilience -- Chapter 2. Water Policy and Governance in Transition: The EU Water Framework Directive -- Chapter 3. The Sustainable Groundwater Management Act (SGMA)—California’s Prescription for Common Challenges of Groundwater Governance -- Chapter 4. Water Policy Reform for Sustainable Development in the Murray-Darling Basin, Australia: Insights from Resilience Thinking -- Chapter 5. Reducing Nutrient Loading from Agriculture to Lake Ecosystems – Contributions of Resilience Principles -- Chapter 6. Reconfiguring water governance for resilient social-ecological systems in South America -- Part III: Exploring the conceptual boundaries and bridges of water resilience -- Chapter 7. Capacities for watershed resilience: persistence, adaptation, and transformation -- Chapter 8. Adaptive Governance in North American Water Systems: a legal perspective on resilience and reconciliation -- Chapter 9. Cross-scale Governance for Urban Water Resilience in Bengaluru and Cape Town -- Chapter 10. Facing Change: Understanding Transitions of River Basin Policies Over Time -- Chapter 11. Conditions and Cautions for Transforming Ocean Governance -- Chapter 12. Extraordinary governance to avoid extraordinary events. Part IV: Conclusion -- Chapter 13. Charting a course for management and governance dimensions of water resilience.
    Abstract: This book synthesizes current knowledge and understanding of management and governance in the context of water resilience; advances theory through synthesis of research and experiences from a variety of disciplinary perspectives. The book highlights the implications of theory and experience for innovation in practice and policy; and it explores frontiers and future research. The book further addresses the need for a consolidated, interdisciplinary approach to the theoretical advances and practical implications of water resilience for academics, resource managers, aid organizations, policy makers and citizens. .
    Type of Medium: Online Resource
    Pages: X, 311 p. 23 illus., 18 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030481100
    URL: https://doi.org/10.1007/978-3-030-48110-0
    DOI: 10.1007/978-3-030-48110-0
    DDC: 551.48
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    The Ganga River Basin: A Hydrometeorological Approach (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Climatology. ; Geotechnical engineering. ; Water. ; Climate Sciences. ; Geotechnical Engineering and Applied Earth Sciences.
    Description / Table of Contents: Water Quality Challenges in Ganga River Basin, India -- Sequential Characterization of Contaminant Plumes using feedback information -- Evaluation of groundwater quality using Multivariate analysis: Rae Bareli District, Ganga Basin, Uttar Pradesh -- A Supervising Grid Model for Identification of Groundwater Pollute -- Study of Methods available for Groundwater and Surfacewater Interaction: A case study on Varanasi, India -- Augmentation of Drinking Water Supply by River Bank Filtration -- River Discharge Study in River Ganga, Varanasi Using Conventional and Modern Techniques -- Review on the Field Applications of River Training Structures for River Bank Protection -- Comparison of conceptual and distributed hydrological Models for runoff Estimation in a River Basin -- Monthly variation in near surface air temperature lapse rate across Ganga Basin, India -- Identification of relationship between precipitation and atmospheric oscillations in Upper Ganga basin -- Utilizing stream networks for regional flood frequency analysis -- Plotting Positions for the Generalized Extreme Value Distribution: A Critique -- Application of Machine Learning Techniques for Clustering of Rainfall Time Series Over Ganges River Basin.
    Abstract: This book presents an overview of the hydrometeorological and hydrological studies and assists in tackling challenges posed by climate and land use land cover changes. The Ganga River is one of the major living streams on the planet earth and very important river system in India. This holy river is a lifeline for approximately five hundred million people. In the last few decades, River Ganges has been subjected to tremendous pressures with respect to both water quantity and water quality. This situation, already one of the alarming magnitudes, has been further provoked by hydrometeorological changes resulting in droughts, floods and reduced groundwater levels and river flows in addition to the poor river health. Thus, it is imperative to assess the various complexities and possible solutions for better management of River Ganges. This book is a valuable addition to the literature and contributes to research on River Ganges which will help better planning and management of Ganga river basin. The hydrological and hydrometeorological aspects covered in this book help practitioners, researchers, policymakers and other stakeholders.
    Type of Medium: Online Resource
    Pages: XVI, 322 p. 119 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030608699
    Series Statement: Society of Earth Scientists Series,
    URL: https://doi.org/10.1007/978-3-030-60869-9
    DOI: 10.1007/978-3-030-60869-9
    DDC: 551.48
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    Essential Tools for Water Resources Analysis, Planning, and Management (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Water. ; Hydrology. ; Mathematical optimization. ; Quantitative research. ; Artificial intelligence Data processing. ; Water. ; Optimization. ; Data Analysis and Big Data. ; Data Science.
    Description / Table of Contents: Modelling and Simulation -- Optimization -- Big data and Databases -- Data mining -- Remote sensing -- Geographical information system -- System dynamics -- Agent-based models -- Game theory -- Conflicts resolution -- Multi-objective optimization -- Multicriteria and multi-attribute decision -- making -- Risk, uncertainty, and reliability.
    Abstract: This book describes tools needed in water resources management, using methods such as optimization algorithms, conflict resolution methods, risk and uncertainty analysis, to better manage water resources and consumption, thus mitigating the present and future global water shortage crisis. It presents the applications of these tools through case studies which demonstrate its benefits of proper management of water resources. This book acts as a reference for students, professors, industrial practitioners and stakeholders in the field of water resources management and hydrology.
    Type of Medium: Online Resource
    Pages: VI, 343 p. 78 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813342958
    Series Statement: Springer Water,
    URL: https://doi.org/10.1007/978-981-33-4295-8
    DOI: 10.1007/978-981-33-4295-8
    DDC: 551.48
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    Advanced Magnetic Adsorbents for Water Treatment : Fundamentals and New Perspectives (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Pollution. ; Chemical engineering. ; Water. ; Pollution. ; Chemical Engineering.
    Description / Table of Contents: Preface -- Chapter 1 Fundamentals of Adsorption -- Chapter 2 Methods of Synthesis of Magnetic Adsorbents -- Chapter 3 Magnetic Biosorbents and their Application in Water Remediation -- Chapter 4 Lignocellulosic Wastes as Precursor of carbonaceous magnetic adsorbents of organic and inorganic pollutants adsorption -- Chapter 5 Magnetic Biochar Fibers for Copper Removal -- Chapter 6 Treatment of Landfill Leachate with Magnetic Adsorbents -- Chapter 7 Removal of Emerging Pollutants and Toxic Metals using Magnetic Adsorbents -- Chapter 8 Magnetically Modified Biological Materials for Dyes Removal -- Chapter 9 Regeneration of magnetic adsorbents saturated by organic pollutants using advanced oxidation technologies -- Chapter 10 Magnetic Nanofibers for Contaminants Removal from Water -- Chapter 11 Magnetic solid phase-based sorbents for isolation/pre-concentration and removal of pesticides -- Chapter 12 Characterization and application of Fe-magnetic materials and nanomaterials for application in the aqueous matrices decontamination -- Chapter 13 Advanced Magnetic Adsorbents Prepared from Emulsion Template for Water Treatment -- Chapter 14 Chitosan Based Magnetic Adsorbents -- Chapter 15 Methods used for performance enhancement of iron based magnetic adsorbents in water systems.
    Abstract: This book compiles 15 chapters about the synthesis, characterizations, and application of many kinds of magnetic adsorbents for water treatment. It is devoted to the scientific community that works with adsorption technologies for water treatment and remediation. Specifically, for professors and Ph.D. students. It is expected that this book serves as an interesting background for researchers in the field of magnetic adsorbents for water treatment.
    Type of Medium: Online Resource
    Pages: XVI, 501 p. 117 illus., 78 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030640927
    Series Statement: Environmental Chemistry for a Sustainable World, 61
    URL: https://doi.org/10.1007/978-3-030-64092-7
    DOI: 10.1007/978-3-030-64092-7
    DDC: 551.48
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    Deep Learning for Hydrometeorology and Environmental Science (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Artificial intelligence. ; Environmental sciences Mathematics. ; Environment. ; Neural networks (Computer science) . ; Human ecology Study and teaching. ; Water. ; Artificial Intelligence. ; Mathematical Applications in Environmental Science. ; Environmental Sciences. ; Mathematical Models of Cognitive Processes and Neural Networks. ; Environmental Studies.
    Description / Table of Contents: Introduction -- Mathematical Background -- Data Preprocessing -- Neural Network -- Training a Neural Network -- Updating Weights -- Improving model performance -- Advanced Neural Network Algorithms -- Deep learning for time series -- Deep learning for spatial datasets -- Tensorflow and Keras Programming for Deep Learning -- Hydrometeorological Applications of deep learning -- Environmental Applications of deep learning.
    Abstract: This book provides a step-by-step methodology and derivation of deep learning algorithms as Long Short-Term Memory (LSTM) and Convolution Neural Network (CNN), especially for estimating parameters, with back-propagation as well as examples with real datasets of hydrometeorology (e.g. streamflow and temperature) and environmental science (e.g. water quality). Deep learning is known as part of machine learning methodology based on the artificial neural network. Increasing data availability and computing power enhance applications of deep learning to hydrometeorological and environmental fields. However, books that specifically focus on applications to these fields are limited. Most of deep learning books demonstrate theoretical backgrounds and mathematics. However, examples with real data and step-by-step explanations to understand the algorithms in hydrometeorology and environmental science are very rare. This book focuses on the explanation of deep learning techniques and their applications to hydrometeorological and environmental studies with real hydrological and environmental data. This book covers the major deep learning algorithms as Long Short-Term Memory (LSTM) and Convolution Neural Network (CNN) as well as the conventional artificial neural network model.
    Type of Medium: Online Resource
    Pages: XIV, 204 p. 189 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030647773
    Series Statement: Water Science and Technology Library, 99
    URL: https://doi.org/10.1007/978-3-030-64777-3
    DOI: 10.1007/978-3-030-64777-3
    DDC: 551.48
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    Water Resource Management in Central Asia and Afghanistan : Current and Future Environmental and Water Issues (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Pollution. ; Bioclimatology. ; Environmental monitoring. ; Geographic information systems. ; Water. ; Pollution. ; Climate Change Ecology. ; Environmental Monitoring. ; Geographical Information System.
    Description / Table of Contents: Chapter 1: Hydrologic Model for Runoff Simulation of the Kyzyl-Suu River -- Chapter 2: Integrated Water Resources and Environmental Management in the Transboundary Rivers Basins of Central Asia -- Chapter 3: Experience of Preparation of River Basin Planning and Management on Water Resource Development, Use and Protection in Main and Minor Transboundary River Basins -- Chapter 4: Assessment of Amu Darya Runoff Changes as a Result of Predicted Climate Change and Reduced Glaciation -- Chapter 5: Climate Change Forecast in Kyrgyzstan for 2050 and 2100 -- Chapter 6: Reactions and Dynamics of Drains on Small Transboundary Rivers with Various Feeding Types and the Effect on Climate Change -- Chapter 7: Assessment of anthropogenic loads on the Talas River Watershed (within the Republic of Kazakhstan) -- Chapter 8:The Glacial Systems of Kyrgyzstan under Climate Change -- Chapter 9: Water Resource Risks to Cotton Agriculture in Uzbekistan: Climate, Policy and Irrigation -- Chapter 10: Groundwater Flooding Risk Assessment Using Microseismic Arrays and VES Techniques in the Northern Part of Bishkek -- Chapter 11: Designing Sustainable Futures: Interdisciplinary Science and Social Creativity -- Chapter 12: Water Reuse for Irrigation in Rural Areas in Japan: Implications/Insights for Central Asia and Afghanistan -- Chapter 13: Physics-Chemical Properties of the Kyzyl-Suu River and its tributaries -- Chapter 14: Environmental and Water Resources Management Study of Ghorband-Panjshir and Kunduz Rivers Basins, Afghanistan -- Chapter 15: Investigation of the High Mountain Vegetation Using Satellite Imagery, Kyrgyzstan -- Chapter 16: New Approaches and Advanced Methodology in Integrated Water Resources Management: Amu Darya River Basin -- Chapter 17: Investigation of the Various Aspects of the Kafirnigan River Basin, Tajikistan. .
    Abstract: The book provides a cross-sectoral, multi-scale assessment of development-directed investigations in the main rivers of wider Central Asia and Afghanistan. The book highlights the development of river systems, water reservoirs, ecosystems and risks as well as the impact of climate change on water resources in Central Asian countries and Afghanistan. It provides information on the genesis of river basins, physical and chemical properties of water in rivers, and the hydrological regimes of the rivers of Central Asia and Afghanistan. The book is useful for scientists and researchers whose work focuses on rivers and the use of water resources, irrigation, ecosystems, risks, water supply, climate change and remote sensing, as well as for students and planners, administrations and other stakeholders in the water sector.
    Type of Medium: Online Resource
    Pages: VII, 193 p. 91 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030683375
    Series Statement: Springer Water,
    URL: https://doi.org/10.1007/978-3-030-68337-5
    DOI: 10.1007/978-3-030-68337-5
    DDC: 551.48
    Language: English
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  • 46
    Online Resource
    Online Resource
    Hydrological Extremes : River Hydraulics and Irrigation Water Management (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Food security. ; Natural disasters. ; Environmental monitoring. ; Sustainability. ; Water. ; Food Security. ; Natural Hazards. ; Environmental Monitoring. ; Sustainability.
    Description / Table of Contents: Intelligent Irrigation Water Management -- River Hydraulics -- Assessment and Monitoring of Hydrological Extremes -- Future Scenarios.
    Abstract: This book presents quality technical papers representing the recent developments in the field of hydrological modeling, water management and water governance including practical applications. The content covers multifarious aspects of hydrology and water resources. It includes an application of the Hydrologic Modelling System (HEC-HMS) which has been successfully demonstrated for assessment of floods. The authors suggest an approach for the mitigation of cyclone disaster through a case study of the Phailin cyclone, whilst considering mitigating pluvial flooding, developing suitable management strategies. The book includes chapters discussing the detrended fluctuation analysis which is carried out for multifractal description of droughts. Drought characteristics are analyzed, and drought indices evolved for drought preparedness/management. The use of science in community planning under changing climate is also studied and discussed. The authors present and experimental study wherein hydraulic coefficients are calibrated by using vertical orifice. A cross flow hybrid hydrokinetic turbine is also evaluated for performance, and high head regulating radial gate designed and studied its sensitivity. This book will appeal to researchers, field practitioners, NGO and other Governmental as well as private water practitioners .
    Type of Medium: Online Resource
    Pages: XII, 446 p. 262 illus., 230 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030591489
    Series Statement: Water Science and Technology Library, 97
    URL: https://doi.org/10.1007/978-3-030-59148-9
    DOI: 10.1007/978-3-030-59148-9
    DDC: 551.48
    Language: English
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  • 47
    Online Resource
    Online Resource
    Water Management and Water Governance : Hydrological Modeling (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Geographic information systems. ; Ecology Methodology. ; Environmental sciences Social aspects. ; Water. ; Geographical Information System. ; Ecological Modelling. ; Environmental Social Sciences.
    Description / Table of Contents: 1. Application of RS and GIS in Watershed Management -- 2. Application of RS and GIS in Agricultural Water Management -- 3. Hydrological Modeling -- 4. Intelligent Water Management -- 5. Water Governance.
    Abstract: This book focusses on hydrological modeling, water management, and water governance. It covers the applications of remote sensing and GIS tools and techniques for land use and land cover classifications, estimation of precipitation, evaluation of morphological changes, and monitoring of soil moisture variability. Moreover, remote sensing and GIS techniques have been applied for crop mapping to assess cropping patterns, computation of reference crop evapotranspiration, and crop coefficient. Hydrological modeling studies have been carried out to address various issues in the water sector. MODFLOW model was successfully applied for groundwater modeling and groundwater recharge estimation. Runoff modeling has been carried out to simulate the snowmelt runoff together with the rainfall and sub-surface flow contributions for snow-fed basins. A study has been included, which predicts the impact of the land use and land cover on stream flow. Various problems in the water sector have been addressed employing hydrological models such as SWAT, ArcSWAT, and VIC. An experimental study has been presented wherein the laboratory performance of rainfall simulator has been evaluated. Hydrological modeling studies involving modifications in the curve number methodology for simulation of floods and sediment load have also been presented. This book is useful for academicians, water practitioners, scientists, water managers, environmentalists, and administrators, NGOs, researchers, and students who are involved in water management with the focus on hydrological modeling, water management, and water governance.. .
    Type of Medium: Online Resource
    Pages: XI, 550 p. 265 illus., 231 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030580513
    Series Statement: Water Science and Technology Library, 96
    URL: https://doi.org/10.1007/978-3-030-58051-3
    DOI: 10.1007/978-3-030-58051-3
    DDC: 551.48
    Language: English
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  • 48
    Online Resource
    Online Resource
    The Worth of Water : Designing Climate Resilient Rainwater Harvesting Systems (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Pollution. ; Environmental policy. ; Sociology. ; Environmental economics. ; Water. ; Pollution. ; Environmental Policy. ; Sociology. ; Environmental Economics.
    Description / Table of Contents: Chapter1: The circular economy of water (CEW) -- Chapter2: Water treatment: pollution removal mechanisms in the rainwater harvesting process -- Chapter3: Supply & demand: multiple waters for multiple purposes and multiple uses -- Chapter4: The components of a rainwater harvesting system: modular, standardised, plug and play -- Chapter5: Climate resilient RWH: a technological portfolio -- Chapter6: Rainwater harvesting design -- Chapter7: The economics of rainwater harvesting -- Chapter8: Rainwater harvesting and the sustainable development goals (SDG's).
    Abstract: There is no more fundamental substance to life on earth than water. Ninety nine percent of all human molecules are water molecules. Three quarter of the earth’s surface is covered by either saltwater or freshwater, yet millions face a daily struggle to access enough water for survival. The effects of ongoing climate change have expanded the water crisis to areas previously considered water secure. This book addresses the role rainwater harvesting (rwh) can play in developing a resilient water infrastructure that will prove adaptive to climate change and its implications. The book features three sections. The first section presents the concepts underpinning a new approach to water infrastructure. The term “the worth of water” was developed to reflect the importance of the social life of water. This encompasses all human relationships with water including the social, cultural, hydrological, political, economic, technical and spiritual. A technology portfolio showcasing the worth of water from the qanats of the ancient world to the modern rain cities is presented. Other concepts discussed include the circular economy of water and the concept of multiple waters for multiple users of multiple qualities. Water and its properties are a function of its peculiar molecular structure and this is illustrated in the book. Rainwater harvesting is considered by the authors as containing an inherent treatment train which functions as a complex water treatment system. The physical, chemical and biological removal mechanisms that form an inherent part of the rwh system are discussed. Part two presents a new rwh design methodology together with design templates and worked examples for the hydraulic and economic analysis of rwh systems. A state-of-the-art literature review of the potential health implications of utilizing rwh is also presented. The final section of the book discusses how rwh can play a vital role in contributing to achieving the sustainable development goals and to living within the planetary boundaries.
    Type of Medium: Online Resource
    Pages: XXIV, 206 p. 199 illus., 193 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030506056
    URL: https://doi.org/10.1007/978-3-030-50605-6
    DOI: 10.1007/978-3-030-50605-6
    DDC: 551.48
    Language: English
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  • 49
    Online Resource
    Online Resource
    The Realities of Adaptive Groundwater Management : Chino Basin, California (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Environmental management. ; Political science. ; Political planning. ; Environmental sciences Social aspects. ; Water. ; Environmental Management. ; Governance and Government. ; Public Policy. ; Environmental Social Sciences.
    Description / Table of Contents: Chapter 1. Introduction: The Realities of Adaptive Management -- Chapter 2. The Natural Physical System of Chino Basin -- Chapter 3. The Development of Water Supplies and Water Conservation in Chino Basin -- Chapter 4. Upstream-Downstream Conflicts, 1930-1960 -- Chapter 5. Setting the Stage for a Chino Basin Management Program: Changes in Water Use, and the Third Santa Ana River Litigation, 1960-1969 -- Chapter 6. The Chino Basin Adjudication -- Chapter 7. The Governance Structure for Chino Basin under the Judgment -- Chapter 8. Water Management in the Basin during the First 20 Years under the Judgment -- Chapter 9. Turbulence: The 1990s in Chino Basin -- Chapter 10. Reconstituting Chino Basin Governance and Management -- Chapter 11. Adapting to Social and Economic Change -- Chapter 12. Adapting to and with the Neighbors -- Chapter 13. Adapting to the Changing Realities of Water Supply -- Chapter 14. Adapting to Water Quality Problems and Priorities -- Chapter 15. Resetting the Safe Yield and Reappointing the Watermaster -- Chapter 16. Looking Ahead: The Reality of Continual Adaptation -- Chapter 17. Lessons from Chino Basin for Adaptive Groundwater Management [note: includes section on California’s Sustainable Groundwater Management Act (SGMA)].
    Abstract: This book has three primary objectives. The first objective is to provide scholars with a more realistic view of adaptive management, without arguing against adaptive management. Adaptive management is necessary as well as desirable, but it is not easy, and demonstrating that through the Chino Basin experience is an important goal. The second objective is to provide practitioners with encouraging yet cautionary lessons about the challenges and benefits of an adaptive approach – in similar fashion as the first objective, the goal here is to endorse the adaptive approach but in a clear-eyed manner that clarifies how hard it is and how much it requires. A third objective is to show all audiences that resource governance systems can fail, change, and succeed. There is no such thing as an ideal institutional design that is guaranteed to work; rather, making institutional arrangements work entails learning and adjustment when they begin to show problems as they inevitably will. .
    Type of Medium: Online Resource
    Pages: XX, 288 p. 19 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030637231
    Series Statement: Global Issues in Water Policy, 27
    URL: https://doi.org/10.1007/978-3-030-63723-1
    DOI: 10.1007/978-3-030-63723-1
    DDC: 551.48
    Language: English
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  • 50
    Online Resource
    Online Resource
    Marine Nitrogen Fixation (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Biogeography. ; Microbiology. ; Freshwater ecology. ; Marine ecology. ; Water. ; Biogeosciences. ; Microbiology. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Chapter1: Nitrogen Fixation in the Marine Environment -- Chapter2: Fundamentals of N2 Fixation -- Chapter3: History of Research on Marine N2 Fixation -- Chapter4: Microorganisms and Habitats -- Chapter5: Measurements of Organism Abundances and Activities -- Chapter6: Factors Controlling N2 Fixation -- Chapter7: Biogeography of N2 Fixation in the Surface Ocean -- Chapter8: N2 Fixation in Ocean Basins -- Chapter9: Marine N2 Fixation, Global Change and the Future -- Chapter10: Summary and Conclusions.
    Abstract: This book aims to serve as a centralized reference document for students and researchers interested in aspects of marine nitrogen fixation. Although nitrogen is a critical element in both terrestrial and aquatic productivity, and nitrogen fixation is a key process that balances losses due to denitrification in both environments, most resources on the subject focuses on the biochemistry and microbiology of such processes and the organisms involved in the terrestrial environment on symbiosis in terrestrial systems, or on largely ecological aspects in the marine environment. This book is intended to provide an overview of N2 fixation research for marine researchers, while providing a reference on marine research for researchers in other fields, including terrestrial N2 fixation. This book bridges this knowledge gap for both specialists and non-experts, and provides an in-depth overview of the important aspects of nitrogen fixation as it relates to the marine environment. This resource will be useful for researchers in the specialized field, but also useful for scientists in other disciplines who are interested in the topic. It would provide a possible text for upper division classes or graduate seminars.
    Type of Medium: Online Resource
    Pages: XV, 186 p. 36 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030677466
    URL: https://doi.org/10.1007/978-3-030-67746-6
    DOI: 10.1007/978-3-030-67746-6
    DDC: 551.48
    Language: English
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  • 51
    Online Resource
    Online Resource
    Heavy Metals in Scleractinian Corals (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Environmental chemistry. ; Environment. ; Water. ; Environmental Chemistry. ; Environmental Sciences.
    Description / Table of Contents: Heavy Metals - An Overview -- Coral Reef Ecosystems -- The Use of Scleractinian Corals for Heavy Metal Studies -- Analytical Techniques Used for Heavy Metal Analysis in Corals.
    Abstract: This book provides an in-depth review of heavy metals in corals, describing the sources of heavy metals in the marine environment and their effect on corals. It is designed to serve as a unique reference for upcoming marine researchers and chemists, advanced undergraduate and postgraduate students as well as those interested in marine pollution with respect to heavy metals. The book explains the basics as well as the state-of-the-art regarding heavy metals and corals and is engaging and clearly written and narrated, providing readers with the fundamental tools about the subject matter that they need in their specific fields. It allows readers to understand and appreciate the interactions between the atmosphere, ocean, and the geosphere. Detailed reference is included for the benefit of the reader. The specific objectives of this book are (i) to inform/educate the reader about persistent pollutants such as heavy metals, (ii) to identify sources of heavy metals in the marine environment, (iii) to inform about route of exposure and uptake of the heavy metal pollutants by corals, (iv) to elaborate about the effect of heavy metal pollutants on the coral reef ecosystems, (v) to discuss the ways in which heavy metal regulation occurs in corals, (vi) to impact current knowledge regarding heavy metals in the marine environment, and (vii) to briefly show chemical analysis and instrumentation for analyzing heavy metals.
    Type of Medium: Online Resource
    Pages: X, 90 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030736132
    Series Statement: SpringerBriefs in Earth Sciences,
    URL: https://doi.org/10.1007/978-3-030-73613-2
    DOI: 10.1007/978-3-030-73613-2
    DDC: 551.48
    Language: English
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  • 52
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    Online Resource
    Climate Change and Groundwater: Planning and Adaptations for a Changing and Uncertain Future : WSP Methods in Water Resources Evaluation Series No. 6 (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Water. ; Hydrology. ; Physical geography. ; Natural disasters. ; Water. ; Earth System Sciences. ; Natural Hazards.
    Description / Table of Contents: 1. Introduction to Climate Change and Groundwater -- 2. Climate and Groundwater Primer -- 3. Historical Evidence for Anthropogenic Climate Change and Climate Modeling Basics -- 4. Intergovernmental Panel on Climate Change and Global Climate Change Projections -- 5. Modeling of Climate Change and Aquifer Recharge and Water Levels -- 6. Sea Level Rise and Groundwater -- 7. Climate Change and Small Islands -- 8. Groundwater Related Impacts of Climate Change on Infrastructure -- 9. Adaptation and Resilience Concepts -- 10. Adaptation Options -- 11. Conjunctive Use -- 12. Climate Change Adaptation - Water Management Decision Making Process -- 13. Regional Hydrological Impacts to Climate Changes and Adaptation Actions and Options -- 14. Applied Climate Change Assessment and Adaptation.
    Abstract: This book attempts to bridge the gap between the climate change research and decision-making communities by exploring the impacts of climate change on groundwater from a more applied perspective. Global climate change will impact groundwater demands, quality, and available supplies, and rising sea level may cause water tables to rise, inundating low-lying coastal areas. Groundwater will increasingly be needed to perform a stabilization role in mitigating fluctuations in the supply of surface waters, serving as a buffer against droughts. Climate change has become a frequent subject in the mass media, and the academic literature on the subject is now enormous. An impediment to climate change adaptation with respect to water is a poor link between the climate change research community and the actual decision-makers responsible for water supply planning. Key issues explored are methods for evaluating potential impacts on climate change on local groundwater systems, the adaptation of decision-making process, and how climate change adaptation can be mainstreamed into the water supply planning.
    Type of Medium: Online Resource
    Pages: XV, 350 p. 54 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030668136
    Series Statement: Springer Hydrogeology,
    URL: https://doi.org/10.1007/978-3-030-66813-6
    DOI: 10.1007/978-3-030-66813-6
    DDC: 551.48
    Language: English
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