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  • 1
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Cardiology. ; Therapeutics. ; Heart Surgery. ; Pharmacology. ; Cardiology. ; Therapeutics. ; Cardiac Surgery.
    Description / Table of Contents: Coronary Artery Disease: From Mechanism to Clinical Practice -- Evidence in guidelines for treatment of coronary artery disease -- Revascularization For Coronary Artery Disease: Principle And Challenges -- Antithrombotic drugs: pharmacology and perspectives -- Lipid modifying drugs: pharmacology and perspectives -- Anti-hypertensive drugs: pharmacology and perspectives -- Pharmaceutical treatment for Heart failure -- Drug discovery for coronary artery disease.
    Abstract: This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.
    Type of Medium: Online Resource
    Pages: IX, 339 p. 7 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811525179
    Series Statement: Advances in Experimental Medicine and Biology, 1177
    DDC: 615
    Language: English
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  • 2
    Keywords: Biotechnology. ; Plant diseases. ; Microbial ecology. ; Bacteria. ; Biology Technique. ; Biotechnology. ; Plant Pathology. ; Microbial Ecology. ; Bacteria. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Hairy Roots Biotechnology Unzipped: A Journey of Reality and Promises -- Chapter 2. Hairy Roots as a Source of Tropane Alkaloids -- Chapter 3. Induction, Metabolite Analysis and Transgenesis of Hairy Roots From Coleus Forskohlii -- Chapter 4. Establishment of Hairy Roots of Endangered Himalayan Plantswertiachirata: A Sustainable Alternative to Extraction from Nature -- Chapter 5. A Protocol for the Selection of Spontaneous Variants From Established Catharanthusroseus Hairy Root Cultures -- Chapter 6. Strategies for the Optimization of Culture Conditions for Increasing Metabolite Production Through Hairy Root Cultures. Monoterpenoid Indole Alkaloid Production in Catharanthus Roseus Hairy Roots -- Chapter 7. Protocol for Enhanced Withaferin-a Production in Elicited Withania Somnifera (l.)Dunal Hairy Root Cultures -- Chapter 8. Establishment of Hairy Root Cultures of Pentalinonandrieuxii for the Production of Betulinic Acid -- Chapter 9. Tropane Alkaloid Production by the Establishment Of Hairy Root Cultures of Brugmansia Candida and Elicitation -- Chapter 10. Elicitation as an Essential Strategy For Enhancing Anthraquinone Accumulation In Hairy Root Cultures of Rubia Tinctorum -- Chapter 11. Establishment of Hairy Root Cultures for the Production of Biopharmaceuticals and Optimization of Methods for Recombinant Protein Secretion In The Culture Medium -- Chapter 12. An Improved Protocol for Agrobacterium Rhizogenes-Mediated Transformation of Recalcitrant Plants for Root Biology Studies: A Case Study of Tea Plants (Camellia Sinensis Var. Sinensis) -- Chapter 13 Functional Analysis of Plant Genes Related to Arbuscular Mycorrhiza Symbiosis Using Agrobacterium Rhizogenes-Mediated Root Transformation and Hairy Root Production -- Chapter 14. Functional Characterization of Genes Involved in Legume Nodulation Using Hairy Root Cultures -- Chapter 15. Fluidigm Biomark Diagnostic Panel for Analysis of the Expression of Nicotiana Tabacum Genes, Associated with Alkaloid Synthesis. .
    Abstract: The book discusses the various methods and protocols available in hairy root culture-based research. The utilization of Agrobacterium mediated genetic transformation and establishment of hairy root cultures has paved the way for large-scale secondary metabolite production in medicinal plants. Presenting recent research and offering insights from eminent research groups, the book covers a range of topics related to hairy root-based applications, including (i) establishment of hairy roots and native production of SM (ii) yield enhancement strategies for increased SM production, like elicitation (iii) hairy roots as a tool for value-added applications such as plant-microbe interaction, characterization of plant genes and root biology studies. As such it is an informative guide and experimental manual for researchers in diverse fields of plant biology.
    Type of Medium: Online Resource
    Pages: XIV, 237 p. 47 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811540554
    Series Statement: Rhizosphere Biology,
    DDC: 660.6
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Pediatrics. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Anti-epileptic drugs in pediatrics -- Current and new therapies for Duchenne Muscular Dystrophy -- Lysosomal diseases -- Mitochondriopathies -- Endocrinology thyroid, pituitary, growth stimulant, growth reduction -- Bone disease – bisphosphonates -- Diabetes type 1 and 3 (insulin; sulfonylurea; others) -- Diabetes type 2 (metformin etc.) -- Dermatology – part 1 urticaria, atopic dermatitis -- Dermatology part 2, ichtyosis, psoriasis -- Cardiovascular part 1- catcholamines, inotropic -- Cardiovascular part 2 – antiarhythmica, anti hypertensives -- Nephrology – dialysis -- How to use drugs in obese children and adolescents -- Haematology – CSFs, erythropoietin -- Antiretroviral/HIV -- Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life -- Antihelminth treatment -- Inflammatory bowel disease -- Constipation; laxatives -- Psychiatric diseases in children and adolescents -- Oncology – cell reducing agents part 1, part 2, part 3 -- Immunosuppressants – organ transplantation -- Bone marrow/stem cell transplantation -- Narcotic sparing approaches and the shift towards paracetamol in neonatal intensive care -- Disorders of puberty: pharmacotherapeutic strategies for management.
    Abstract: This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.
    Type of Medium: Online Resource
    Pages: VIII, 538 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504946
    Series Statement: Handbook of Experimental Pharmacology, 261
    DDC: 615
    Language: English
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  • 4
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Atoms. ; Molecules. ; Biotechnology. ; Atomic, Molecular and Chemical Physics.
    Description / Table of Contents: Photonic crystals for biomolecule sensing applications -- Recent advances in Surface Plasmon Resonance for biosensing applications and future prospects -- Surface-enhanced Raman Scattering for biology and medicine -- Nanophotonic techniques for single cell analysis -- Biointerface Characterization by Nonlinear Optical Spectroscopy -- Chemiluminescence and its biomedical applications -- Luminescent Conjugated Polymer Dots for Biomedical Applications -- Dark-Field Hyperspectral Imaging (DF-HSI) Modalities for Characterization of Single Molecule and Cellular Processes -- Additive Manufacturing Technologies based on Photopolymerization.
    Abstract: This book summarizes the latest advances in nanophotonics for biomedical applications, including biomolecular sensing and imaging, additive fabrications, and biophotonics. The engineering of nanophotonics will have significant impacts on the life sciences and medicine alike. Given its scope, the book offers a valuable asset for researchers, scientists, engineers, and graduate students in the fields of biomedical engineering, electrical engineering, materials sciences, optics, biology, and medicine.
    Type of Medium: Online Resource
    Pages: V, 282 p. 160 illus., 126 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811561375
    DDC: 660.6
    Language: English
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  • 5
    Keywords: Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Abstract: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 425 p. 70 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685102
    Series Statement: Handbook of Experimental Pharmacology, 264
    DDC: 615
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Radiology. ; Spectrum analysis. ; Pharmaceutical chemistry. ; Nutrition   . ; Biomedical Research. ; Radiology. ; Spectroscopy. ; Pharmaceutics. ; Nutrition.
    Description / Table of Contents: Ch 1: Electron Spin Resonance- An Introdcution -- Ch 2: ESR – Applications in Healthcare and Pharmaceutical Science -- Ch 3: ESR Applications in Paleontology and Geochronology -- Ch 4: ESR Applications in Food Science.
    Abstract: This book introduces the audience with basic theoretical and experimental aspects of Electron Spin Resonance (ESR) Spectroscopy. It further talks about ESR spectroscopy applications in Healthcare & Pharmaceutical Science, Paleontology & Geochronology and Food Science. Mathematical details have been kept to a necessary minimum and emphasis is given to highlight the applications of the technique.
    Type of Medium: Online Resource
    Pages: X, 72 p. 32 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030641986
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    DDC: 610.72
    Language: English
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  • 7
    Keywords: Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Abstract: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Type of Medium: Online Resource
    Pages: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030700638
    Series Statement: Handbook of Experimental Pharmacology, 265
    DDC: 615
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Computer vision. ; Radiology. ; Biotechnology. ; Computer Vision. ; Radiology.
    Description / Table of Contents: Introduction -- Preliminaries -- Fuzzy spatial objects (fuzzy geometry and topology, set theoretic operations) -- Mathematical morphology -- Distances and similarities between fuzzy sets -- Machine learning in image processing and understanding -- Fusion -- Spatial relations -- Structural representations.
    Abstract: This book provides a thorough overview of recent methods using higher level information (object or scene level) for advanced tasks such as image understanding along with their applications to medical images. Advanced methods for fuzzy image processing and understanding are presented, including fuzzy spatial objects, geometry and topology, mathematical morphology, machine learning, verbal descriptions of image content, fusion, spatial relations, and structural representations. For each methodological aspect covered, illustrations from the medical imaging domain are provided. This is an ideal book for graduate students and researchers in the field of medical image processing. This book also: Enriches reader understanding of the latest fuzzy sets methods using higher level information (object or scene level) for advanced tasks, such as image understanding Shares many insights into fuzzy spatial objects, including fuzzy geometry and topology as well as set theoretical operations Covers in detail machine learning in image processing and understanding, with special focus on clustering, classification, and basic and advanced fuzzy methods .
    Type of Medium: Online Resource
    Pages: XIII, 302 p. 97 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031194252
    DDC: 660.6
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical policy. ; Quality of life. ; Biomedical Research. ; Health Policy. ; Quality of Life Research.
    Description / Table of Contents: Foreword: Challenges & Opportunities for LGBT Populations and Cancer in Global Oncology -- Introduction -- Africa -- A Double Dose Of Stigma – Being Gay And Living With Cancer In Kenya -- Sexual Orientation, Gender Identity and Cancer in South Africa -- Americas -- Making the Situation of TLGBI People around Cancer visible: Observations from the Andean Region -- Cancer Care Challenges for the LGBT Population in Brazil -- Cancer and the SGM Population in Canada and the United States of America -- South-East Asia -- The South-East Asia Region: Societal Conditions for LGBT Health and Cancer Research -- Europe -- Foreword: The Eurocentralasian Lesbian* Community Perspective on Cancer and LBQ women: Advocating for more Research and Activism Collaboration -- LGBT+ and Cancer in the WHO European Region: Current Situation in 12 Eastern European and Central Asian Countries -- Sexual and Gender Minorities and Cancer in Germany: The Striking Absence of Understanding their Cancer-related Needs -- LGBT Populations and Cancer in the UK -- Eastern Mediterranean -- LGBT Populations and Cancer in the Eastern Mediterranean Region: Insights and Challenges with a Focus on Lebanon -- Western Pacific -- LGBT Populations and Cancer in Australia and New Zealand -- Challenges in Cancer Control Confronting the LGBT Population in China: Health Risks, Unique Barriers, and Unmet Needs -- What Have We Learned about Cancer and the Global LGBT Community? -- Index.
    Abstract: Lesbian, Gay, Bisexual, and Transgender (LGBT) also known as sexual and gender minority (SGM) populations have been the focus of global attention. Most importantly, LGBT populations have been addressed in the context of human rights in multiple reports and other activities by the United Nations and other international organizations. There is great variation among countries in the recognition of LGBT individuals’ human rights. A global focus on LGBT populations’ health is still limited, with the notable exception of HIV research. This book on LGBT populations and cancer in the global context is, therefore, an important step in that it will broaden the focus on LGBT populations’ health. Globally, cancer is the second leading cause of death. Cancer morbidity and mortality are increasing disproportionately among populations in lower-income countries. A review conducted by the World Health Organization (WHO) found that of the 82% of member states (158) countries, only 35% of the national cancer control plans addresses vulnerable population, including LGBT populations. These findings reflect an increasing awareness about equity when addressing cancer prevention and control, including LGBT populations. This book addresses LGBT populations’ cancer burden across countries that range from high- to low-income countries to support efforts in diverse countries that are working towards reducing LGBT populations’ cancer burden. It documents place-specific challenges that impede progress towards reducing the LGBT cancer burden as well as critically assesses the variation in cancer control efforts that target LGBT populations and cancer to support progress at a global scale. This book includes six sections that cover the six WHO regions, with each chapter written by an author from the specific region s/he is covering. Each chapter makes use of a template that contextualizes the region, local data collection/availability, risk factors, cancer prevention, detection, diagnosis, treatment, and survivorship.
    Type of Medium: Online Resource
    Pages: X, 335 p. 3 illus., 2 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031065859
    DDC: 610.72
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human physiology. ; Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human Physiology.
    Description / Table of Contents: Successful Vaccines -- Immunogenicity and Immunodominance in Antibody Responses -- Immunogen Design -- Adjuvants -- Tools to screen vaccines -- Targeting glycans on human pathogens for vaccine design -- BnAbs and highly antigenically variable pathogens.
    Abstract: Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine. .
    Type of Medium: Online Resource
    Pages: VII, 180 p. 16 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030580049
    Series Statement: Current Topics in Microbiology and Immunology, 428
    DDC: 615
    Language: English
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