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  • 1
    Online Resource
    Online Resource
    Circulating Tumor Cells : Advances in Liquid Biopsy Technologies (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.
    Abstract: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).
    Type of Medium: Online Resource
    Pages: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031229039
    Series Statement: Current Cancer Research,
    URL: https://doi.org/10.1007/978-3-031-22903-9
    DOI: 10.1007/978-3-031-22903-9
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Immuno-Oncology Crosstalk and Metabolism (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Tumors Immunological aspects. ; Cancer Treatment. ; Biochemistry. ; Metabolism. ; Cell biology. ; Immunology. ; Cancer Biology. ; Cancer Microenvironment. ; Tumour Immunology. ; Cancer Therapy. ; Metabolic Pathways. ; Immunology.
    Description / Table of Contents: 1 Cancer Metabolism and Aggressive Tumor Behaviour -- 2 Immune Cell Metabolism and Function -- 3 Cancer Cell Metabolism Effecting Immune function -- 4 Immune Cell Metabolites as Fuel for Cancer Cells -- 5 Immuno-Onco metabolism and Resistance to Therapy -- 6 Targeting Immuno-Onco metaolism in Cancers -- 7 Timing of the major metabolic switches in immune cell activation and differentiation during cancer development.
    Abstract: This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.
    Type of Medium: Online Resource
    Pages: X, 218 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811662263
    URL: https://doi.org/10.1007/978-981-16-6226-3
    DOI: 10.1007/978-981-16-6226-3
    DDC: 571.978
    Language: English
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  • 3
    Online Resource
    Online Resource
    Dietary Research and Cancer (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Biology. ; Cancer Treatment. ; Biotechnology. ; Molecular biology. ; Physiology. ; Cancer Biology. ; Biological Sciences. ; Cancer Therapy. ; Biotechnology. ; Molecular Biology. ; Physiology.
    Description / Table of Contents: Chapter 1. Introduction to Dietary Research and Cancer -- Chapter 2. Healthy Dietary Patterns and Cancer -- Chapter 3. Frequently Asked Diet and Nutrition Related Questions by Cancer Survivors -- Chapter 4. Dietary Recommendations of Worldwide Cancer Related Organizations -- Chapter 5. Outcome of ‘Diet and Cancer’ Related Clinical Trials -- 6. Diet and Cancer Epigenetics: A Step Towards Developing Cancer Epigenetic Diet -- 7. Role of Dietary Ingredients on Expression of Oncogenic and Tumor Suppressor miRNA -- 8. Can Diet Influence Metastasis? -- 9. Impact of Dietary Interventions on Cancer Stem Cells -- 10. Interaction of Dietary Metabolites with Anti-cancer Drug Targets -- 11. Revisiting the Anticancer Drug-Food Interactions -- 12. Functional Foods, Nutraceuticals, and Dietary Supplements in Cancer Prevention -- 13. Do Antioxidants Really Help Cancer Patients? The Puzzle of Benefits and Perils -- 14. Market of Dietary Supplements: Analysis of Health Benefits and Risk in Cancer -- 15. Cancer and Fasting: Can Fasting/Calorie Restriction (CR) or Fasting Mimicking Diet (FMD) Helps Fight Cancer? Molecular Basis of Fasting Response -- 16. Do Fasting, CR, and FMD Improves the Chemotherapy Response, Reduce Off Target Toxicities and Enhance Antitumor Immunity? Illusion or Clinical Reality? -- 17. Future Prospectus of Dietary Interventions in the Integrated Management of Cancer.
    Abstract: This book reviews all important aspects of dietary research associated with cancer with the aim of shedding new light on these conditions through combined understanding of traditional and new paradigms. The book is divided into 17 chapters, the first portion reinterprets healthy diets for cancer based on up-to-date evidence from a network science perspective, examining the dietary patterns, outcome of diet related clinical trials, emerging framework of molecular mechanisms and interactions of dietary interventions and their applications in personalized diet, ground realities of benefits and regulatory frame work for functional foods, nutraceuticals and supplements in cancer prevention and upcoming future prospectus in diet-cancer research.. The later part of the book discusses recent advances in understanding of the elaborative discourse on cancer and fasting, covering, for example, calorie restriction and fasting mimicking diet. Finally, different Dietary research and approaches are considered in the context of novel intervention for cancer research. Dietary Research in Cancer will be of interest for all researchers, nutritionists, students and clinicians in the field.
    Type of Medium: Online Resource
    Pages: XX, 197 p. 57 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811660504
    URL: https://doi.org/10.1007/978-981-16-6050-4
    DOI: 10.1007/978-981-16-6050-4
    DDC: 571.978
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cancer Neuroscience (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Neurosciences. ; Immunotherapy. ; Cancer Biology. ; Cancer Therapy. ; Neuroscience. ; Cancer Microenvironment. ; Immunotherapy.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.
    Abstract: This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.
    Type of Medium: Online Resource
    Pages: XII, 202 p. 21 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324291
    URL: https://doi.org/10.1007/978-3-031-32429-1
    DOI: 10.1007/978-3-031-32429-1
    DDC: 571.978
    Language: English
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  • 5
    Online Resource
    Online Resource
    Hepatobiliary Cancers: An Interdisciplinary Approach (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Immunotherapy. ; Cancer Genetic aspects. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Tumour Immunology. ; Immunotherapy. ; Cancer Genetics and Genomics. ; Cancer Stem Cells.
    Description / Table of Contents: Interdisciplinary Approach in Hepatobiliary Cancers -- Liver Cancer: Interdisciplinary Approach -- The Immune System in Liver Cancer: From Beginning to Progression -- The Tumor Microenvironment in Hepatocellular Carcinoma -- Metabolic Alterations of Hepatocellular Cancer Stem Cells -- Τhe Role of Senescence in NASH-related HCC -- Regulators of Genetic Risk for the Progression of Non-alcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Reconstruction of Transcriptional Network and Signature-Based Metabolic Profiling -- Tumor Microenvironment and Immunotherapy in Advanced Biliary Tract Cancers -- Fibrosis and Immunotherapy in Hepatocellular Carcinoma -- Liver Cancer and the Curative Potential of Nanomedicine -- Locoregional Therapies for Hepatocellular Carcinoma -- Drug Resistance in Hepatocellular Carcinoma -- Liver Stereotactic Body Radiotherapy.
    Abstract: Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.
    Type of Medium: Online Resource
    Pages: XI, 365 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031445286
    Series Statement: Interdisciplinary Cancer Research, 3
    URL: https://doi.org/10.1007/978-3-031-44528-6
    DOI: 10.1007/978-3-031-44528-6
    DDC: 571.978
    Language: English
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  • 6
    Online Resource
    Online Resource
    Gastrointestinal Cancers: An Interdisciplinary Approach (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Oncology. ; Immunotherapy. ; Tumors Immunological aspects. ; Nanomedicine. ; Cancer Biology. ; Cancer Therapy. ; Oncology. ; Immunotherapy. ; Tumour Immunology. ; Cancer Nanotechnology.
    Description / Table of Contents: Interdisciplinary Approach in Gastrointestinal Cancers -- Gastrointestinal Cancers: What Is the Real Board of Microenvironment and the Role of Microbiota-Immunity Axis -- Epithelial-Mesenchymal Transition in Gastrointestinal Cancer: From a Basic to a Clinical Approach -- Metabolomics of Gastrointestinal Cancers -- Deregulation of Immune System in Gastric Cancer Development, How Immune Nutrition Might Restore the Functions of Immune Cells -- Helicobacter pylori Virulence Factors, Pathogenicity, and Gastric Cancer -- Gastric Cancer and Helicobacter pylori -- Role of Neuromodulators in Regulation of the Tumor Microenvironment of Gastric and Colorectal Cancers -- The Role of Tumor Microenvironment in Colon Cancer -- Unraveling the Esophageal Cancer Tumor Microenvironment: Insights and Novel Immunotherapeutic Strategies -- The Interplay Between Immunity and Gut Microbiota in Colon Cancer -- Immunotherapy in Gastrointestinal Cancer Focusing on CAR-T Cell Therapy -- Development of Biocompatible Nanocarriers for the Treatment of Colorectal Cancer -- Challenges of Onco-therapeutics in Early Onset Colorectal Cancer -- Unintentional Weight Loss and Malnutrition After Esophageal Cancer and Treatment -- Current Clinical Landscape of Immunotherapeutic Approaches in Pancreatic Cancer Treatment. The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy. .
    Abstract: Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.
    Type of Medium: Online Resource
    Pages: XI, 404 p. 22 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031483714
    Series Statement: Interdisciplinary Cancer Research, 4
    URL: https://doi.org/10.1007/978-3-031-48371-4
    DOI: 10.1007/978-3-031-48371-4
    DDC: 571.978
    Language: English
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  • 7
    Online Resource
    Online Resource
    Artificial Intelligence and Precision Oncology : Bridging Cancer Research and Clinical Decision Support (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Cancer. ; Oncology. ; Medical screening. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Oncology. ; Cancer Screening. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Chapter 1. Introduction: The Application of AI in Precision Oncology: Tailoring Diagnosis, Treatment, and the Monitoring of Disease Progression to the Patient -- Part I. Artificial Intelligence for Screening, Diagnosis, Monitoring in Precision Oncology -- Chapter 2. Application of AI in Novel Biomarkers Detection that Induce Drug Resistance, Enhance Treatment Regimens and Advancing Precision Oncology -- Chapter 3. Use of Artificial Intelligence in Implementing Mainstream Precision Medicine to Improve Traditional Symptom-driven Practice of Medicine: Allowing Early Interventions and Tailoring better-personalized Cancer Treatments -- Chapter 4. AI as a Novel Approach for Exploring ccfNAs in Personalized Clinical Diagnosis and Prognosis: Providing Insight into the Decision-Making in Precision Oncology -- Chapter 5. AI-Enhanced Digital Pathology and Radiogenomics in Precision Oncology -- Part II. Artificial Intelligence and Omics in Precision Oncology -- Chapter 6. Epigenetics Analysis Using Artificial Intelligence in the Era of Precision Oncology -- Chapter 7. Association of Metabolomics with AI in Precision Oncology: Emerging Perspectives for More Effective Cancer Care -- Chapter 8. Artificial Intelligence Application to Microbiomics Data for Improved Clinical Decision Making in Precision Oncology -- Part III. Artificial Intelligence in Cancer Therapy and the Clinical Applications -- Chapter 9. AI and Nanotechnology in Realizing the Goal of Precision Medicine: Tailoring the Best Treatment for Personalized Cancer Treatment -- Chapter 10. Artificial Intelligence-Based Medical Devices Revolution in Cancer Screening: Impact into Clinical Practice -- Chapter 11. Intelligent Drug Design and Use for Cancer Treatment: The Roles of AI and Precision Oncology in Targeting Patient-Specific Splicing Profiles -- Chapter 12. Applying Artificial Intelligence Prediction Tools for Advancing Precision Oncology in Immunotherapy: Future Perspectives in Personalized Care -- Chapter 13. Employing AI-Powered Decision Support Systems in Recommending the Most Effective Therapeutic Approaches for Individual Cancer Patients: Maximizing Therapeutic Efficacy -- Chapter 14. AI-Pathway Companion in Clinical Decision Support: Enabling Personalized and Standardized Care Along Care Pathways in Oncology -- Chapter 15. AI Tools Offering Cancer Clinical Applications for Risk Predictor, Early Detection, Diagnosis, and Accurate Prognosis: Perspectives in Personalised Care -- Chapter 16. Conclusion and Insights into the Future of AI in Precision Oncology.
    Abstract: This book highlights the use of artificial intelligence (AI), big data and precision oncology for medical decision making in cancer screening, diagnosis, prognosis and treatment. Precision oncology has long been thought of as ideal for the management and treatment of cancer. This strategy promises to revolutionize the treatment, control, and prevention of cancer by tailoring tests, treatments and predictions to specific individuals or population groups. In order to accomplish these goals, vast amounts of patient or population group specific data needs to be integrated and analysed to be able to identify key patterns or features which can be used to define or characterize the disease or the response to the disease in these individuals. These patterns or features can be as varied as molecular patterns or features in medical images. This level of data analysis and integration can only be achieved through the use of AI. The book is divided into three parts starting with a section on the use of artificial intelligence for screening, diagnosis and monitoring in precision oncology. The second part: Artificial intelligence and Omics in precision oncology, highlights the use of AI and epigenetics, metabolomics, microbiomics in precision oncology. The third part covers artificial intelligence in cancer therapy and its clinical applications. It also highlights the use of AI tools for risk prediction, early detection, diagnosis and accurate prognosis. This book, written by experts in the field from academia and industry, will appeal to cancer researchers, clinical oncologists, pathologists, medical students, academic teaching staff and medical residents interested in cancer research as well as those specialising as clinical oncologists.
    Type of Medium: Online Resource
    Pages: XIV, 315 p. 64 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031215063
    URL: https://doi.org/10.1007/978-3-031-21506-3
    DOI: 10.1007/978-3-031-21506-3
    DDC: 571.978
    Language: English
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  • 8
    Online Resource
    Online Resource
    Therapeutic potential of Cell Cycle Kinases in Breast Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancers. ; Cancer Therapy. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Chapter 1 An introduction to breast cancer -- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators -- Chapter 4 Cell cycle and cancer -- Chapter 5 cell cycle dysregulation in breast cancer -- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation -- Chapter 7 Breast tumor micro environment and CDks -- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis -- Chapter 9 CDK1 Dysregulation in Breast Cancer -- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers -- Chapter 11 Therapeutic implications of CDKs in Breast Cancer -- Chapter 12 Novel CDK Inhibitors in Breast Cancer -- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach -- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer -- Chapter 15 CDk inhibitor for treatment of breast cancer -- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer -- Chapter 17 Different cyclins and their significance in Breast cancer.
    Abstract: This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.
    Type of Medium: Online Resource
    Pages: XVII, 373 p. 133 illus., 92 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811989117
    URL: https://doi.org/10.1007/978-981-19-8911-7
    DOI: 10.1007/978-981-19-8911-7
    DDC: 571.978
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cancer Research: An Interdisciplinary Approach (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Stem cells. ; Cytology. ; Medical genetics. ; Immunology. ; Cancer Biology. ; Cancer Therapy. ; Cancer Stem Cells. ; Cell Biology. ; Medical Genetics. ; Immunology.
    Description / Table of Contents: Interdisciplinary Approaches in Cancer Research -- Role of Immune Cells in the Tumor Microenvironment -- Spatial Transcriptomic Approaches for Understanding the Tumor Microenvironment (TME) -- Role of Mesenchymal Stem/Stromal Cells in Cancer Development -- Cancer-associated Fibroblasts and Their Role in Cancer Progression -- The Role of Tumoroids in Cancer Research -- Myokines Expression in Cancer Cachexia -- Epigenetics in Cancer Biology -- Epigenetic Regulation of Cancer by Natural Touch: Phytochemicals and Epigenetic Regulation -- Telomerase Reverse Transcriptase in Humans: From Biology to Cancer Immunity -- Molecular Mechanisms of Metal-induced Carcinogenesis -- Epi-drugs Targeting RNA Dynamics in Cancer -- Oncologic Emergencies: Pathophysiology, Diagnosis, and Initial Management -- Malignancies in Inborn Errors of Immunity -- Hematopoietic Stem Cell Transplantation in Patients with Inborn Errors of Immunity and Malignancy -- Personalized Immuno-oncology with Immunodeficiency Mouse Models -- Allergy and Cancer: New Perspectives -- Depression and Cancer: the Inflammatory Bridge -- Impact of Cancer-Related Sarcopenia on Systemic Immune Status -- Surveillance of Subclinical Cardiovascular Complications in Childhood Cancer Survivors: Exercise as a Diagnostic and Therapeutic Modality.
    Abstract: Cancer is a major public health concern and one of the leading causes of death. There is no simple solution for this complex disease, therefore interdisciplinary approaches might help to find solutions to many unanswered questions and challenges about cancer. The rapid flow of interdisciplinary research in cancer during recent years has increased our understanding of the nature of cancers. Such interdisciplinary approaches could be helpful for both the diagnosis and the development of more effective therapeutic strategies. The “Interdisciplinary Cancer Research” series publishes comprehensive volumes on different cancers and presents the most updated and peer-reviewed articles on human cancers. Over the past decade, increased cancer research has greatly improved our understanding of the nature of cancerous cells which has led to the development of more effective therapeutic strategies to treat cancers. This interdisciplinary series is of special value to researchers and practitioners working on cell biology, immunology, hematology, biochemistry, genetics, oncology and related fields. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN).
    Type of Medium: Online Resource
    Pages: XI, 611 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324581
    Series Statement: Interdisciplinary Cancer Research, 1
    URL: https://doi.org/10.1007/978-3-031-32458-1
    DOI: 10.1007/978-3-031-32458-1
    DDC: 571.978
    Language: English
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  • 10
    Online Resource
    Online Resource
    Hypoxia in Cancer: Significance and Impact on Cancer Therapy (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Cancers. ; Cancer Therapy. ; Cancer Biology. ; Tumour Immunology.
    Description / Table of Contents: Chapter 1. Hypoxia and its Biological Implications for Cancer Therapy -- Chapter 2. Hypoxia's function in cancer -- Chapter 3. Role of Hypoxia and Reactive Oxygen Species in cancer biology -- Chapter 4. Hypoxic tumor microenvironment: driver for cancer progression -- Chapter 5. Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression -- Chapter 6. Hypoxia Regulated Gene Expression and Metastasis -- Chapter 7. piRNA based cancer therapy in hypoxic tumor -- Chapter 8. MicroRNA Signatures of Tumor Hypoxia -- Chapter 9. Hypoxia and the Metastatic Cascade -- Chapter 10. Hypoxia and Extra Cellular Matrix-major drivers of tumor Metastasis -- Chapter 11. Role of Hypoxia in Cancer Therapy – Introduction -- Chapter 12. Hypoxic regulation of telomerase gene expression in cancer -- Chapter 13. CRISPR/Cas9-editing-based modeling of tumor hypoxia -- Chapter 14. Tumor-on-a-chip: Microfluidic models for Hypoxic tumor microenvironment -- Chapter 15. Imaging the Hypoxic Tumor microenvironment in cancer models -- Chapter 16. Hypoxia-targeting drugs as new cancer chemotherapy agents Hypoxia-targeting drugs as new cancer chemotherapy agents - Molecular Insights -- Chapter 17. Identification of Hypoxia targeting drugs in the tumor microenvironment and prodrug Strategies for Targeting Tumor Hypoxia -- Chapter 18. Hypoxia Induced Apoptosis in Cancer Development -- Chapter 19. Hypoxia in drug resistance and radioresistance.
    Abstract: This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.
    Type of Medium: Online Resource
    Pages: XV, 447 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819903139
    URL: https://doi.org/10.1007/978-981-99-0313-9
    DOI: 10.1007/978-981-99-0313-9
    DDC: 571.978
    Language: English
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  • 11
    Online Resource
    Online Resource
    Evolutionary Dynamics of Malignancy : The Genetic and Environmental Causes of Cancer (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Animal models. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Models. ; Cancer Therapy. ; Cancer Genetics and Genomics. ; Cancer Microenvironment.
    Description / Table of Contents: Chapter 1: Cancer as a Disease of Cell Proliferation -- Chapter 2: Genetic and Chromosomal Instability -- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function -- Chapter 4: The DNA Damage Checkpoint -- Chapter 5: Dynamics of the Spindle Assembly Checkpoint -- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance -- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy -- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy -- Chapter 9: The Cancer Stem Cell and Tumour Progression -- Chapter 10: Evading the antitumour immune response -- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention -- Chapter 12: In science, all conclusions are provisional.
    Abstract: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.
    Type of Medium: Online Resource
    Pages: XIV, 269 p. 96 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031325731
    URL: https://doi.org/10.1007/978-3-031-32573-1
    DOI: 10.1007/978-3-031-32573-1
    DDC: 571.978
    Language: English
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  • 12
    Online Resource
    Online Resource
    Genetics and Epigenetics of Breast Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Genetic aspects. ; Cancer Treatment. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1. Breast cancer -- Chapter 1.1. Epidemiology -- Chapter 1.2. Etiology -- Chapter 1.3. Types of breast cancer -- Chapter 1.4. Signs and symptoms -- Chapter 1.5. Stages -- Chapter 1.6. Diagnosis -- Chapter 1.7. Treatment -- Chapter 2. Genetic landscape of breast carcinogenesis -- Chapter 2.1. Hormone receptor positive breast cancer -- Chapter 2.1. Her2 positive breast cancer -- Chapter 2.2. Triple negative breast cancer -- Chapter 3. Epigenetic involvement in breast carcinogenesis -- Chapter 3.1. Histone modification -- Chapter 3.2. DNA methylation -- Chapter 3.3. miRNA -- Chapter 4. Breast cancer control -- Chapter 4.1. Conventional drugs targeting Genetic and Epigenetics in Breast cancer -- Chapter 4.2. Pitfalls of conventional therapy -- Chapter 4.3. Natural remediation -- Chapter 5. Conclusion.
    Abstract: This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment.
    Type of Medium: Online Resource
    Pages: X, 87 p. 13 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811999253
    URL: https://doi.org/10.1007/978-981-19-9925-3
    DOI: 10.1007/978-981-19-9925-3
    DDC: 571.978
    Language: English
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  • 13
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    Online Resource
    Cancer Biomarkers in Diagnosis and Therapeutics (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Tumor markers. ; Cancer. ; Cancer Treatment. ; Nanomedicine. ; Tumour Biomarkers. ; Cancer Biology. ; Cancer Therapy. ; Cancer Nanotechnology.
    Description / Table of Contents: Chapter 1. Introduction to cancer biomarkers -- Chapter 2.Technologies for identification and validation of cancer biomarkers -- Chapter 3. BIOMARKERS FOR CANCER DRUG DEVELOPMENT -- Chapter 4. Clinical proteomics: diagnostics and prognostic markers of Cancer -- Chapter 5.Microbiome as cancer biomarkers -- Chapter 6. Predictive biomarkers for anticancer drugs -- Chapter 7. Biomarkers in Cancer Survival and Drug Resistance -- Chapter 8. Biomarkers in tumor recurrence and metastasis -- Chapter 9. Biomarkers for Cancer Immunotherapy -- Chapter 10. Role of Biomarkers in Personalized Medicine -- Chapter 11.Development of Novel Cancer Biomarkers for Diagnosis and Prognosis -- Chapter 12. Nanotechnology for Cancer Biomarkers.
    Abstract: This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.
    Type of Medium: Online Resource
    Pages: XII, 365 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811657597
    URL: https://doi.org/10.1007/978-981-16-5759-7
    DOI: 10.1007/978-981-16-5759-7
    DDC: 571.978
    Language: English
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  • 14
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    Online Resource
    Cancer Stem Cells: Basic Concept and Therapeutic Implications (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Stem cells. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Stem Cells. ; Cancer Therapy. ; Cancer Biology. ; Cancer Genetics and Genomics.
    Description / Table of Contents: 1. Introduction and perspective in carcinogenesis -- 2. Origin and Development of Cancer Stem Cells -- 3. Detection and Isolation of Cancer Stem Cells -- 4. The genetic and epigenetic landscape of cancer stem cells -- 5. Metabolism of Cancer Stem Cell -- 6. Plasticity of Cancer Stem Cell -- 7. Cancer Stem Cells in Cancer Initiation and Progression -- 8. Cancer Stem Cells and Metastasis -- 9. Roles of Cancer Stem Cells in Therapy resistance and Disease Recurrence -- 10. Novel therapeutics targeting cancer stem cell surface markers -- 11. Therapeutics targeting cancer stem cells signalling pathways -- 12. Cancer stem cells therapeutics delivery and EPR effect -- 13. Immunotherapy against cancer stem cells -- 14. Engineering nanobody targeting cancer stem cells -- 15. Biological barriers for drug delivery to cancer stem cells -- 16. Cancer Stem Cell Markers in Haematological Malignancies -- 17. Diagnostic and Prognostic Significance of Cancer Stem Cells Surface Markers -- 18. Diagnostic and prognostic implications of cancer stem cells transcription factors -- 19. Diagnostic and prognostic significance of intracellular markers of CSCs in patients with cancers. .
    Abstract: This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.
    Type of Medium: Online Resource
    Pages: XVI, 372 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819931859
    URL: https://doi.org/10.1007/978-981-99-3185-9
    DOI: 10.1007/978-981-99-3185-9
    DDC: 571.978
    Language: English
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  • 15
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    Online Resource
    Microfluidics and Biosensors in Cancer Research : Applications in Cancer Modeling and Theranostics (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Biochemical markers. ; Microfluidics. ; Pharmacology. ; Cancer Treatment. ; Cancer Biology. ; Biomarkers. ; Microfluidics. ; Pharmacology. ; Cancer Therapy.
    Description / Table of Contents: Part 1. Fundamentals of Microfluidics and Biosensors -- Chapter 1. Fundamentals of Biosensors and Detection Methods -- Chapter 2. How to Get Away with Gradients -- Chapter 3. Sensors and Biosensors in Organs-on-a-chip Platforms -- Chapter 4. Current Trends in Microfluidics and Biosensors for Cancer Research Applications -- Part 2. Modelling the Tumor Microenvironment and Its Dynamic Events -- Chapter 5. The Tumor Microenvironment — an Introduction for the Development of Microfluidic Devices -- Chapter 6. Biomaterials for Mimicking and Modelling Tumor Micro-environment -- Chapter 7. Advancing Tumor Microenvironment Research by Combining Organs-on-chips and Biosensors -- Chapter 8. Microfluidic-driven Biofabrication and the Engineering of Cancer-like Microenvironments -- Chapter 9. Advances in 3d Vascularized Tumor-on-a-chip Technology -- Part 3. Cancer Detection and Diagnosis -- Chapter 10. Biosensors Advances: Contributions to Cancer Diagnostics and Treatment -- Chapter 11. Flexible Sensing Systems for Cancer Diagnostics -- Chapter 12. Coupling Micro-physiological Systems and Biosensors for Improving Cancer Biomarkers Detection -- Chapter 13. Microfluidic Biosensor-based Devices for Rapid Diagnosis and Effective Anti-cancer Therapeutic Monitoring for Breast Cancer Metastasis -- Chapter 14. Liquid Biopsies: Flowing Biomarkers -- Chapter 15. From Exosomes to Circulating Tumor Cells: Using Microfludics to Detect High Predictive Cancer Biomarkers -- Chapter 16. Microfluidics for the Isolation and Detection of Circulating Tumor Cells -- Chapter 17. Evolution in Automatized Detection of Cancer Cells: Advances in Magnetic Microcytometers -- Chapter 18. Droplet-based Microfluidic Chip Design, Fabrication and Use for Ultrahigh-throughput DNA Analysis and Quantification -- Chapter 19. Emerging Microfluidic and Biosensor Technologies for Improved Cancer Theranostics -- Part 4. Clinical Applications: Towards Personalized Medicine -- Chapter 20. Microfluidics for Cancer Biomarker Discovery, Research and Clinical Application -- Chapter 21. Methods for the Detection of Circulating Biomarkers in Cancer Patients -- Chapter 22. Advances in Microfluidics for the Implementation of Liquid Biopsy in Clinical Routine.
    Abstract: This book offers a comprehensive overview of the development and application of microfluidics and biosensors in cancer research, in particular, their applications in cancer modeling and theranostics. Over the last decades, considerable effort has been made to develop new technologies to improve the diagnosis and treatment of cancer. Microfluidics has proven to be a powerful tool for manipulating biological fluids with high precision and efficiency and has already been adopted by the pharmaceutical and biotechnology industries. With recent technological advances, particularly biosensors, microfluidic devices have increased their usefulness and importance in oncology and cancer research. The aim of this book is to bring together in a single volume all the knowledge and expertise required for the development and application of microfluidic systems and biosensors in cancer modeling and theranostics. It begins with a detailed introduction to the fundamental aspects of tumor biology, cancer biomarkers, biosensors and microfluidics. With this knowledge in mind, the following sections highlight important advances in developing and applying biosensors and microfluidic devices in cancer research at universities and in the industry. Strategies for identifying and evaluating potent disease biomarkers and developing biosensors and microfluidic devices for their detection are discussed in detail. Finally, the transfer of these technologies into the clinical environment for the diagnosis and treatment of cancer patients will be highlighted. By combining the recent advances made in the development and application of microfluidics and biosensors in cancer research in academia and clinics, this book will be useful literature for readers from a variety of backgrounds. It offers new visions of how this technology can influence daily life in hospitals and companies, improving research methodologies and the prognosis of cancer patients.
    Type of Medium: Online Resource
    Pages: XIX, 590 p. 100 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031040399
    Series Statement: Advances in Experimental Medicine and Biology, 1379
    URL: https://doi.org/10.1007/978-3-031-04039-9
    DOI: 10.1007/978-3-031-04039-9
    DDC: 571.978
    Language: English
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  • 16
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    Online Resource
    The Heterogeneity of Cancer Metabolism (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Metabolism. ; Cancer Treatment. ; Cancer Metabolism. ; Cancer Therapy. ; Cancer Biology.
    Description / Table of Contents: Part I. Basic Metabolism of Cancer Cells -- Glucose Metabolism in Cancer the Warburg effect and Beyond -- Glutamine Metabolism in Cancer -- The Heterogeneity of Lipid Metabolism in Cancer -- Part II. Heterogeneity of Cancer Metabolism -- The Multifaceted Glioblastoma: from Genomic Alterations to Metabolic Adaptions -- The Intricate Metabolism of Pancreatic Cancers -- The heterogeneity of breast cancer metabolism for therapy -- Non-Hodgkin Lymphoma Metabolism -- The Heterogeneity Metabolism of Renal Cell Carcinomas -- The Heterogeneity Metabolism of Liver Cancer -- Different Tumor Microenvironments Lead to Different Metabolic Phenotypes -- The Intratumoral Heterogeneity of Cancer Metabolism -- Cancer Stem Cells Metabolism -- Metabolism of Immune cells in the Tumor Microenvironment -- Part III. Relationship between Cancer Cells and Cancer-Associated Fibroblasts -- Metabolic Relationship between Cancer-Associated Fibroblasts and Cancer Cells -- Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts -- Part IV. The metabolic interplay between cancer and other diseases -- Diabetes and Cancer: the Epidemiological and Metabolic Associations -- Bridging the Metabolic Parallels between Neurological Diseases and Cancer -- Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy -- Index.
    Abstract: This open access volume will introduce recent discoveries in the field of cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, etc. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students. .
    Type of Medium: Online Resource
    Pages: XXIII, 271 p. 55 illus., 54 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030657680
    Series Statement: Advances in Experimental Medicine and Biology, 1311
    URL: https://doi.org/10.1007/978-3-030-65768-0
    DOI: 10.1007/978-3-030-65768-0
    DDC: 571.978
    Language: English
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  • 17
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    Online Resource
    Polyphenols-based Nanotherapeutics for Cancer Management (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Nanomedicine. ; Immunology. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Cancer Nanotechnology. ; Immunology. ; Cancer Stem Cells.
    Description / Table of Contents: Chapter 1_Introduction and classification of natural polyphenols -- Chapter 2_Polyphenol intakes and risk of cancer: An epidemiological scenario -- Chapter 3_Polyphenols-based prevention and therapeutics in different cancers -- Chapter 4_Effect of polyphenols on signaling pathways -- Chapter 5_Role of polyphenols in modulating gene expression in different cancers -- Chapter 6_Effect of polyphenols on Inflammation and immune response in cancer -- Chapter 7_Epigenetic basis of polyphenols in cancer prevention and therapy -- Chapter 8_Polyphenols and cancer stem cells (CSCs) -- Chapter 9_Polyphenols as modulator of oxidative stress in cancer disease -- Chapter 10_Development of novel therapeutics for enhanced polyphenol delivery -- Chapter 11_Toxicological concern of different bioactive polyphenols as anticancer agents.
    Abstract: This book reviews the applications of polyphenols in cancer treatment. The initial chapter of the book classifies different polyphenols and discusses their biological and chemical properties. The subsequent chapters then explore the diverse role of polyphenols in modulating signal transduction pathways in cancer including, cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis, and metastasis. This book highlights the usefulness of polyphenol enriched seafood in modulating the anti-tumor and anti-inflammatory cytokine IFN-γ. The book also presents nanoformulation of polyphenol as a promising strategy for their enhanced bioavailability and targeted delivery. Lastly, the book examines the toxicity and safety evaluations of polyphenols as anticancer agents.
    Type of Medium: Online Resource
    Pages: XIII, 437 p. 85 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811649356
    URL: https://doi.org/10.1007/978-981-16-4935-6
    DOI: 10.1007/978-981-16-4935-6
    DDC: 571.978
    Language: English
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  • 18
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    Online Resource
    Redox Regulation and Therapeutic Approaches in Cancer (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Metabolism. ; Cancer Treatment. ; Biochemistry. ; Oxidation-reduction reaction. ; Cancer Metabolism. ; Cancer Therapy. ; Redox Biology.
    Description / Table of Contents: 1. ROS, redox regulation and signaling in cancer cells -- 2. ROS and redox regulation/signaling and metabolism in cancer stem cells -- 3. . ROS/Redox regulation with dietary phytochemicals and role in anticancer activity -- 4. ROS/Redox signaling and apoptosis/necroptosis/autophagy in cancer -- 5. Cancer Metastasis, ROS/redox signaling and PCD resistance/redox metabolism -- 6. Immune system, redox signaling and cancer immunity -- 7. P53, ROS- redox regulation signaling, metabolic reprogramming and autophagy in cancer -- 8. Cell cycle, DNA damage-repair systems and impact of redox regulation in cancer -- 9. ROS, redox regulation and anticancer therapy -- 10. Perspectives in ROS/redox regulation cancer therapy.
    Abstract: This book aims to provide an association of the major redox-sensitive pathways and networks involved in cancer. The initial chapter of the book discusses basic information about oxidative stress, its generation, and regulation (redox regulation or redox homeostasis) via cell signaling in normal and cancer cells. The book also explores antioxidants and metabolic events in cancer cells compared to normal cells. It further covers the application of nanoparticles in redox regulation in cancer cells. The role of redox regulation in cancer therapy, its influence, and its involvement in programmed cell death (PCD), metastasis, immune system, p53, and cell cycle/DNA damage repair pathways have been discussed in separate chapters. It further reviews the importance of dietary phytochemicals in redox regulation in normal and cancer pathophysiology. Towards the end, the book focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells.
    Type of Medium: Online Resource
    Pages: XI, 431 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819973422
    URL: https://doi.org/10.1007/978-981-99-7342-2
    DOI: 10.1007/978-981-99-7342-2
    DDC: 571.978
    Language: English
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