Abstract
Human immune interferon (IFN-γ) differs from leukocyte interferon (IFN-α) and fibroblast interferon (IFN-β) in cell origin, inducing agents, physical and biological properties1 and amino acid sequence2. These differences have led to interest in possible differences in the biological properties of IFN-γ compared with IFN-α and IFN-β. IFN-γ has the same broad range of biochemical and biological actions as do IFN-α and IFN-β, although relative potencies vary depending on the cell type and function investigated3. There has so far been no direct evidence that IFN-γ alters normal cell functions differently from other interferons1,3. We report here striking qualitative and quantitative differences in the intracellular response of human fibro-blasts to IFN-γ compared with IFN-α and IFN-β. Two-dimensional gel electrophoresis demonstrates, in addition to the induction of a common group of polypeptides, the existence of a set of polypeptides whose synthesis is uniquely induced by IFN-γ.
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Weil, J., Epstein, C., Epstein, L. et al. A unique set of polypeptides is induced by γ interferon in addition to those induced in common with α and β interferons. Nature 301, 437–439 (1983). https://doi.org/10.1038/301437a0
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DOI: https://doi.org/10.1038/301437a0
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