Abstract
We have determined a major antigenic site for virus neutralization on the capsid protein VP1 of poliovirus type 3. Antigenic mutant viruses selected for resistance to individual monoclonal antibodies had point mutations concentrated in a region 277–294 bases downstream from the start of the region of viral RNA coding for VP1. These findings provide the basis for an improved understanding of the molecular basis of virus neutralization.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Minor, P. D., Kew, O. & Schild, G. C. Nature 299, 109–110 (1982).
Perez-Bercoff, R. (ed.) The Molecular Biology of Picornaviruses (Plenum, New York, 1979).
Sabin, A. B. & Boulger, L. R. J. biol. Standard. 1, 115–118 (1973).
Minor, P. D. et al. J. gen. Virol. 61, 167–176 (1982).
Ferguson, M. et al. Lancet ii, 122–124 (1982).
Holland, J. et al. Science 215, 1577–1585 (1982).
Laver, W. G. et al. Virology 98, 226–237 (1979).
Wiktor, T. J. & Koprowski, H. J. exp. Med. 152, 99–112 (1980).
Yewdell, J. W. & Gerhard, W. J. Immunology 128, 2670–2675 (1982).
Yewdell, J. W. & Gerhard, W. A. Rev. Microbiol. 35, 185–206 (1981).
Minor, P. D. J. Virol. 34, 73–84 (1980).
Nottay, B. K., Kew, O. M., Hatch, M. H., Heyward, J. T. & Obijeski, J. F. Virology 108, 405–423 (1981).
World Health Organisation Lancet ii, 968–970 (1981).
Kew, O. M., Nottay, B. K., Hatch, M. H., Nakano, J. H. & Obijeski, J. F. J. gen. Virol. 56, 337–347 (1981).
Minor, P. D. J. gen. Virol. 59, 307–317 (1982).
Silberklang, M., Gillum, A. M. & Raj Bhandary, U. L. Meth. Enzym. 59, 58–109 (1979).
Nomoto, A. et al. Virology 112, 217–227 (1981).
Frisby, D. Nucleic Acids Res. 4, 2975–2995 (1977).
Donis-Keller, H., Maxam, A. M. & Gilbert, W. Nucleic Acids Res. 4, 2527–2538 (1977).
Kitamura, N. et al. Nature 291, 547–553 (1981).
Racaniello, V. R. & Baltimore, D. Proc. natn. Acad. Sci. U.S.A. 78, 4887–4891 (1981).
Nomoto, A. et al. Proc. natn. Acad. Sci. U.S.A. 79, 5793–5797 (1982).
Emini, E. A., Jameson, B. A., Lewis, A. J., Larsen, G. R. & Wimmer, E. J. Virol. 43, 997–1005 (1982).
Strohmaier, K., Franze, R. & Adam, K. H. J. gen. Virol. 59, 295–306 (1982).
Bittle, J. L. et al. Nature 298, 30–33 (1982).
Gerhard, W., Yewdell, J. W., Frankel, M. & Webster, R. Nature 290, 713–717 (1981).
Wiley, D. C., Wilson, I. A. & Skehel, J. J. Nature 289, 373–378 (1981).
Bachrach, H. L., Moore, D. M., McKercher, P. D. & Polatnick, J. J. Immun. 115, 1636–1641 (1975).
Meloen, R. H., Rowlands, D. J. & Brown, F. J. gen. Virol. 45, 761–763 (1979).
Lund, G. H., Ziola, B. R., Salmi, A. & Scrabra, D. G. Virology 78, 35–44 (1977).
Lonberg-Holm, K. & Butterworth, B. E. Virology 71, 207–216 (1976).
Thorpe, R., Minor, P. D., Mackay, A., Spitz, M. & Schild, G. C. J. gen. Virol. 63, 487–492 (1982).
Blondel, B., Crainic, R. & Horodniceanu, F. C. r. hebd. Séanc. Acad. Sci., Paris 294, 91–94 (1982).
Beatrice, S. T., Katze, M. G., Zajac, B. A. & Crowell, R. L. Virology 104, 426–438 (1980).
Dreesmann, G. R. et al. Nature 295, 158–160 (1982).
Lerner, R. A. et al. Proc. natn. Acad. Sci. U.S.A. 78, 3403–3407 (1981).
Müller, G. M., Shapira, M. & Arnon, R. Proc. natn. Acad. Sci. U.S.A. 79, 569–573 (1982).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Minor, P., Schild, G., Bootman, J. et al. Location and primary structure of a major antigenic site for poliovirus neutralization. Nature 301, 674–679 (1983). https://doi.org/10.1038/301674a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/301674a0
This article is cited by
-
A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes
Nature Communications (2023)
-
Structure of the complex between the Fab fragment of a neutralizing antibody for type 1 poliovirus and its viral epitope
Nature Structural & Molecular Biology (1995)
-
Characterization of neutralizing antibodies to bovine enterovirus elicited by synthetic peptides
Archives of Virology (1992)
-
Neutralizing epitopes of feline calicivirus
Archives of Virology (1991)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.