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Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse

Nature volume 306, pages 756–760 (1983)Cite this article

Abstract

A cDNA clone corresponding to a mRNA present at elevated levels in transformed fibroblasts encodes a Qa / Tla class I major histocompatibility complex (MHC) antigen. High levels of this mRNA are found in all tumour cells tested; the transcript can undergo alternative splicing; and a repetitive sequence within the transcription unit has the characteristics of a transposable element. The immunological implications of MHC gene activation in tumour cells are discussed.

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References

  1. Scott, M. R. D., Westphal, K-H. & Rigby, P. W. J. Cell 34, 557–567 (1983).

    Article  CAS  PubMed  Google Scholar 

  2. Rigby, P. W. J. et al. in Genetic Manipulation: Impact on Man and Society (eds Starlinger, P. & Illmensee, K. ) (ICSU Press, Miami, in the press).

  3. Lalanne, J. L. et al. Nucleic Acids Res. 10, 1039–1049 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Reyes, A. A., Schold, M., Itakura, K. & Wallace, R. B. Proc. natn. Acad. Sci. U.S.A. 79, 3270–3274 (1982).

    Article  ADS  CAS  Google Scholar 

  5. Weiss, E. et al. EMBO J. 2, 453–462 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Reyes, A. A., Schold, M. & Wallace, R. B. Immunogenetics 16, 1–9 (1982).

    Article  CAS  PubMed  Google Scholar 

  7. Moore, K. W., Sher, B. T., Sun, Y. H., Eakle, K. A. & Hood, L. Science 215, 679–682 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Margulies, D. H. et al. J. Immun. 130, 463–470 (1983).

    CAS  PubMed  Google Scholar 

  9. Steinmetz, M. et al. Cell 25, 683–692 (1981).

    Article  CAS  PubMed  Google Scholar 

  10. Krayev, A. S. et al. Nucleic Acids Res. 10, 7461–7475 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Kramerov, D. A., Lekakh, I. V., Samarina, O. P. & Ryskov, A. P. Nucleic Acids Res. 10, 7477–7491 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Parnes, J. R., Robinson, R. R. & Seidman, J. G. Nature 302, 449–452 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  13. Parnes, J. R. & Seidman, J. G. Cell 29, 661–669 (1982).

    Article  CAS  PubMed  Google Scholar 

  14. Kress, M., Cosman, D., Khoury, G. & Jay, G. Cell 34, 189–196 (1983).

    Article  CAS  PubMed  Google Scholar 

  15. Murphy, D., Brickell, P. M., Latchman, D. S., Willison, K. & Rigby, P. W. J. Cell 35, 865–871 (1983).

    Article  CAS  PubMed  Google Scholar 

  16. Morello, D. et al. Nature 296, 260–262 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Croce, C. M. et al. Proc. natn. Acad. Sci. U.S.A. 78, 5754–5758 (1981).

    Article  ADS  CAS  Google Scholar 

  18. Artzt, K. & Jacob, F. Transplantation 17, 632–634 (1974).

    Article  CAS  PubMed  Google Scholar 

  19. Jacob, F. Immun. Rev. 33, 3–32 (1977).

    Article  CAS  PubMed  Google Scholar 

  20. Stern, P., Martin, G. R. & Evans, M. J. Cell 6, 455–465 (1975).

    Article  Google Scholar 

  21. Winoto, A., Steinmetz, M. & Hood, L. Proc. natn. Acad. Sci. U.S.A. 80, 3425–3429 (1983).

    Article  ADS  CAS  Google Scholar 

  22. Michaelson, J. et al. Transplant Proc. (in the press).

  23. Klein, J., Figueroa, F. & David, C. S. Immunogenetics 17, 553–596 (1983).

    Article  CAS  PubMed  Google Scholar 

  24. Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  25. Zinkernagel, R. M. & Doherty, P. C. Nature 251, 547–548 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Zinkernagel, R. M. & Doherty, P. C. Adv. Immun. 27, 55–177 (1979).

    Google Scholar 

  27. Klein, J., Juretic, A., Baxevanis, C. N. & Nagy, Z. A. Nature 291, 455–460 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  28. Avner, P. R. et al. Immunogenetics 7, 103–115 (1978).

    Article  CAS  PubMed  Google Scholar 

  29. Johnson, L. L. et al. Immunogenetics 18, 137–145 (1983).

    Article  CAS  PubMed  Google Scholar 

  30. Levine, A. J. & Teresky, A. K. Immunogenetics 13, 405–412 (1981).

    Article  CAS  PubMed  Google Scholar 

  31. Ostrand-Rosenberg, S., Rider, T.M. & Twarowski, A. Immunogenetics 10, 607–612 (1980).

    Article  CAS  PubMed  Google Scholar 

  32. Shedlovsky, A., Clipson, L. J., Vandeberg, J. C. & Dove, W. F. Immunogenetics 13, 413–419 (1981).

    Article  CAS  PubMed  Google Scholar 

  33. Siegler, E. L., Tick, N., Teresky, A. K., Rosenstraus, M. & Levine, A. J. Immunogenetics 9, 207–220 (1979).

    Article  Google Scholar 

  34. Stern, P. L., Gidlund, M., Orn, A. & Wigzell, H. Nature 285, 341–342 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  35. Levine, A. J. Adv. Cancer Res. 37, 75–109 (1982).

    Article  CAS  PubMed  Google Scholar 

  36. Kiessling, R. & Wigzell, H. Immun. Rev. 44, 165–208 (1979).

    Article  CAS  PubMed  Google Scholar 

  37. Castro, J. E., Hunt, R., Lance, E. M. & Medawar, P. B. Cancer Res. 34, 2055–2060 (1974).

    CAS  PubMed  Google Scholar 

  38. Medawar, P. B. & Hunt, R. Nature 271, 164–165 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  39. Sikora, K., Stern, P. & Lennox, E. Nature 269, 813–815 (1977).

    Article  ADS  CAS  PubMed  Google Scholar 

  40. Medawar, P. Cancer Res. 34, 2053–2054 (1974).

    CAS  PubMed  Google Scholar 

  41. Evans, R. & Alexander, P. in Immunobiology of the Macrophage (ed. Nelson, D. S. ) 535–576 (Academic, New York, 1976).

    Book  Google Scholar 

  42. Cook, J. L., Hibbs, J. B. & Lewis, A. M. Proc. natn. Acad. Sci. U.S.A. 77, 6773–6777 (1980).

    Article  ADS  CAS  Google Scholar 

  43. Schrier, P. I., Bernards, R., Vaessen, R. T. M. J., Houweling, A. & van der Eb, A. J. Nature 305, 771–775 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  44. Hyman, R. & Stallings, V. J. natn. Cancer Inst. 52, 429–436 (1974).

    Article  CAS  Google Scholar 

  45. Dunn, T. B. & Potter, M. J. natn. Cancer Inst. 18, 587–602 (1957).

    CAS  Google Scholar 

  46. Schulman, M., Wilde, C. D. & Kohler, G. Nature 276, 269–270 (1978).

    Article  ADS  Google Scholar 

  47. Malawista, S. E. & Weiss, M. C. Proc. natn. Acad. Sci. U.S.A. 71, 927–931 (1974).

    Article  ADS  CAS  Google Scholar 

  48. Maxam, A. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Cancer Research Campaign, Eukaryotic Molecular Genetics Research Group, Department of Biochemistry, Imperial College of Science and Technology, London, SW7 2AZ, UK

    Paul M. Brickell, David S. Latchman, David Murphy & Peter W. J. Rigby

  2. Chester Beatty Laboratories, Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK

    Keith Willison

Authors
  1. Paul M. Brickell
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  2. David S. Latchman
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  3. David Murphy
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  4. Keith Willison
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  5. Peter W. J. Rigby
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Brickell, P., Latchman, D., Murphy, D. et al. Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse. Nature 306, 756–760 (1983). https://doi.org/10.1038/306756a0

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