Abstract
The mammalian Y chromosome encodes a testis-determining factor (termed TDF in the human), a master regulator of sex differentiation. Embryos with a Y chromosome develop testes and become males whereas embryos lacking a Y chromosome develop ovaries and become females. Expression of H–Y, a minor histocompatibil-ity antigen, may also be controlled by a gene on the Y chromosome, and it has been proposed that this antigen is the testis-determining factor1. We have tested the postulated identity of H–Y and TDF in the human. H–Y typing with T cells was carried out on a series of sex-reversed humans (XX males and XY females), each shown by DNA hybridization to carry part but not all of the Y chromosome. This deletion analysis maps the gene for H–Y to the long arm or centromeric region of the human Y chromosome, far from the TDF locus, which maps to the distal short arm.
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References
Wachtcl, S. S., Ohno, S., Koo, G. C. & Boyse, E. A. Nature 257, 235–236 (1975).
Bennett, D. et al. Nature 265, 255–257 (1977).
Simpson, E., Edwards, P., Wachtel, S. S., McLaren, A. & Chandler, P. Immunogenetics 13, 355–358 (1981).
McLaren, A., Simpson, E., Tomonari, K., Chandler, P. & Hogg, H. Nature 312, 552–555 (1984).
Simpson, E. Cell 44, 813–814 (1986).
Vergnaud, G. et al. Am. J. hum. Genet. 38, 109–124 (1986).
Page, D. C. Cold Spring Harb. Symp. quant. Biol 51, 229–235 (1986).
Affara, N. A. et al. Nucleic Acids Res. 14, 5353–5373 (1986).
Affara, N. A. et al. Nucleic Acids Res. 14, 5375–5387 (1986).
Goulmy, E. Progress in Allergy 36, 44–72 (1985).
Horai, S., van der Poel, J. J. & Goulmy, E. Immunogenetics 16, 135–142 (1982).
Andersson, M., Page, D. C. & de la Chapelle, A. Science 233, 786–788 (1986).
Disteche, C. M. et al. Proc natn. Acad. Sci. U.S.A 83, 7841–7844 (1986).
Goulmy, E., van Leeuwen, A., Blokland, E., Sachs, E. S. & Geraedts, J. P. M. Immunogenetics 17, 523–531 (1983).
Eichwald, E. J. & Silmser, C. R. Transplant. Bull 2, 148 (1955).
Simpson, E. et al. Immunology 57, 345–349 (1986).
Silvers, W. K., Gasser, D. L. & Eicher, E. M. Cell 28, 439–440 (1982).
Tiepolo, L. & Zuflardi, O. Hum. Genet. 34, 119–124 (1976).
Burgoyne, P. S., Levy, E. R. & McLaren, A. Nature 320, 170–172 (1986).
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Simpson, E., Chandler, P., Goulmy, E. et al. Separation of the genetic loci for the H–Y antigen and for testis determination on human Y chromosome. Nature 326, 876–878 (1987). https://doi.org/10.1038/326876a0
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DOI: https://doi.org/10.1038/326876a0
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