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Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

Nature volume 368, pages 703–710 (1994)Cite this article

Abstract

The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient in ET-1. These ET-1-/- homozygous mice die of respiratory failure at birth and have morphological abnormalities of the pharyngeal-arch-derived craniofacial tissues and organs. ET-1+/- heterozygous mice, which produce lower levels of ET-1 than wild-type mice, develop elevated blood pressure. These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis.

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Authors and Affiliations

  1. The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-Ku, Tokyo, 113, Japan

    Yukiko Kurihara, Hiroki Kurihara, Hiroshi Suzuki, Tatsuhiko Kodama, Koji Maemura, Ryozo Nagai & Yoshio Yazaki

  2. Department of Pathology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-Ku, Tokyo, 113, Japan

    Hideaki Oda & Takatoshi Ishikawa

  3. Department of Physiology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-Ku, Tokyo, 113, Japan

    Tomoyuki Kuwaki, Wei-Hua Cao & Mamoru Kumada

  4. Department of Geriatrics, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-Ku, Tokyo, 113, Japan

    Yasuyoshi Ouchi

  5. Chugai Pharmaceutical Co. Ltd, Komakado, Gotenba, Shizuoka, 412, Japan

    Hiroshi Suzuki, Nobuo Kamada & Kouichi Jishage

  6. Department of Reproductive and Developmental Biology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, 108, Japan

    Sadahiro Azuma & Yutaka Toyoda

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Kurihara, Y., Kurihara, H., Suzuki, H. et al. Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1. Nature 368, 703–710 (1994). https://doi.org/10.1038/368703a0

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