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A complex clathrate hydrate structure showing bimodal guest hydration

Nature volume 397, pages 420–423 (1999)Cite this article

Abstract

Interactions between hydrophobic groups in water1, as well as biomolecular hydration more generally2,3,4, are intimately connected to the structure of liquid water around hydrophobic solutes. Such considerations have focused interest on clathrate hydrates: crystals in which a hydrogen-bonded network of watermolecules encages hydrophobic guest molecules with which the water interacts only by non-directional van der Waals forces. Three structural families of clathrate hydrates have hitherto been recognized: cubic structure I (2MS·6ML·46H2O) (ref. 5), cubic structure II (16MS·8ML·136H2O) (ref. 5) and hexagonal structure H (ML·3MS·2MS·34H2O) (refs 6, 7) hydrates (here ML and MS are the hydrophobic guest sites associated with large and small cavities, respectively). Here we report a new hydrate structure: 1.67 choline hydroxide·tetra- n-propylammonium fluoride·30.33H2O. This structure has a number of unusual features; in particular the choline guest exhibits both hydrophobic and hydrophilic modes of hydration. Formally the structure consists of alternating stacks of structure H and structure II hydrates, and might conceivably be found in those settings (such as seafloor deposits over natural-gas fields) in which clathrate hydrates form naturally.

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Figure 1: Unit cell of 1.67choline hydroxide·tetra-n-propylammonium fluoride· 30.33H2O.
Figure 2: Guest molecules in the cages of the hydrate structure.

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Acknowledgements

We thank the NATO Science Programme for partial support of this work in the form of a Collaborative Research Grant to K.A.U.

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  1. Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, K1A 0R6, Ontario, Canada

    Konstantin A. Udachin & John A. Ripmeester

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Correspondence to John A. Ripmeester.

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Udachin, K., Ripmeester, J. A complex clathrate hydrate structure showing bimodal guest hydration . Nature 397, 420–423 (1999). https://doi.org/10.1038/17097

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