Abstract
THE presence of the pituitary1, or, more specifically, the presence of the erythrosinophilic cells of the pro-adenohypophysis2, is necessary for fresh-water survival in the euryhaline cyprinodont, Fundulus heteroclitus. Failure, with symptoms of asthenia, is correlated with a fall in serum chloride. Hypophysectomized F. heteroclitus can be maintained in fresh-water by intraperitoneal injections of Fundulus pituitary brei. Crude pituitary preparations from other species may be partially effective (perch, rat). Replacement therapy with synthetic or partially purified hormones led to the discovery that mammalian adenohypophyseal preparations with prolactin activity can prevent failure3,4. Purified ovine prolactin was highly effective, and significant prolongation or maintenance of survival was observed with bovine prolactin and with primate growth hormone preparations containing prolactin activity. Ovine prolactin also prolongs fresh-water survival in hypophysectomized Poecilia latipinna5, Xipho-phorus maculatus6, and Tilapia mossambica7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Burden, C. E., Biol. Bull., 110, 8 (1956).
Ball, J. N., Gen. Comp. Endocrinol., 5, 181 (1965).
Pickford, G. E., and Phillips, J. G., Science, 130, 453 (1959).
Pickford, G. E., Robertson, E. E., and Sawyer, W. H., Gen. Comp. Endocrinol., 5, 160 (1965).
Ball, J. N., and Olivereau, M., C.R. Acad. Sci., Paris, 259, 1443 (1964).
Schreibman, M. P., and Kallman, K. D., Amer. Zool., 4, 417 (1964).
Handin, R. I., Nandi, J., and Bern, H. A., J. Exp. Zool., 157, 339 (1964).
Grafflin, A. L., Amer. J. Physiol., 97, 610 (1931). Firly, S., C.R. Soc. Biol., 110, 247 (1932). Raffy, A., C.R. Soc. Biol., 144, 1649 (1949). Drilhon, A., C.R. Acad. Sci., Paris, 235, 1167 (1952).
Egami, N., and Ishii, S., Tenth Pacific Sci. Congr., Symp. Abstr., 159 (1961).
Blüm, V., and Fiedler, K., Naturwiss., 51, 149 (1964).
Stanlee, J. G., and Fleming, W. R., Amer. Zool., 3, 502 (1963); and personal communication.
Ball, J. N., and Ensor, D. M., J. Endocrinol., 32, 267 (1965).
Chester Jones, I., Phillips, J. G., and Bellamy, D., Gen. Comp. Endocrinol., Suppl. 1, 36 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PICKFORD, G., PANG, P. & SAWYER, W. Prolactin and Serum Osmolality of Hypophysectomized Killifish, Fundulus heteroclitus, in Fresh-water. Nature 209, 1040–1041 (1966). https://doi.org/10.1038/2091040a0
Issue Date:
DOI: https://doi.org/10.1038/2091040a0
This article is cited by
-
Some aspects of sodium balance in the freshwater cyprinodontFundulus olivaceus
Journal of Comparative Physiology (1972)
-
Branchial Reduction and Renal Stimulation of (Na+, K+)-ATPase by Prolactin in Hypophysectomized Killifish in Fresh Water
Nature (1970)
-
Action de la prolactine chez l'Anguille
Zeitschrift f�r Zellforschung und Mikroskopische Anatomie (1969)
-
Action de la prolactine chez l'anguille intacte III. Effet sur la Structure Histologique du Rein
Zeitschrift f�r Zellforschung und Mikroskopische Anatomie (1968)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
