Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Induction of Tyrosine Transaminase in Rat Liver by Actidione

Nature volume 210, pages 530–531 (1966)Cite this article

Abstract

ACTIDIONE (cyloheximide) inhibits protein synthesis in yeasts, certain protozoa and mammalian cell lines1–3. It is a toxic compound for some mammalian species, for example, rats; however, in these cases, hydrocortisone acts as an antidote against such poisoning4. We recently reported5 that actidione in rats stimulates the adrenal cortex by way of the anterior pituitary. The stress reaction protected rats against actidione while hypo-physectomy or adrenalectomy made them more sensitive to actidione poisoning5. Furthermore, mice (which are normally highly resistant to actidione poisoning4,5) became sensitive to actidione after adrenalectomy5.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Siegel, M. R., and Sisler, H. G., Biochim. Biophys. Acta, 87, 70 (1964).

    CAS  PubMed  Google Scholar 

  2. Kerridge, J., J. Gen. Microbiol., 19, 497 (1958).

    Article  CAS  Google Scholar 

  3. Bennett, L. L., Smithers, D., and Ward, C. T., Biochim. Biophys. Acta, 87, 60 (1964).

    PubMed  Google Scholar 

  4. Greig, M. E., and Gibbons, A. J., Toxicol. App. Pharmacol., 1, 598 (1959).

    Article  CAS  Google Scholar 

  5. Fiala, S., and Fiala, E. S., Biochim. Biophys. Acta, 103, 699 (1965).

    Article  CAS  Google Scholar 

  6. Fiala, S., Sproul, E. E., and Fiala, A. E., Proc. Soc. Exp. Biol. Med., N.Y., 94, 517 (1957).

    CAS  PubMed  Google Scholar 

  7. Siegel, M. R., thesis, Univ. Maryland (1962).

  8. Craeser, E. H., J. Gen. Microbiol., 12, 282 (1955).

    Google Scholar 

  9. Knox, W. E., Auerbach, V. H., and Lin, E. C. C., Physiol. Rev., 36, 164 (1956).

    Article  CAS  Google Scholar 

  10. Kenney, F. T., and Flora, R. M., J. Biol. Chem., 236, 302 (1963).

    Google Scholar 

  11. Litwack, G., and Diamondstone, T. I., J. Biol. Chem., 238, 302 (1963).

    CAS  PubMed  Google Scholar 

  12. Knox, W. E., in Methods of Enzymology, 2, edit. by Colowick, P., and Kaplan, N. O. (Academic Press, New York, 1955).

    Google Scholar 

  13. Lin, E. C. C., and Knox, W. E., Biochim. Biophys. Acta, 26, 85 (1957).

    Article  CAS  Google Scholar 

  14. Canellakis, E. S., and Cohen, P. P., J. Biol. Chem., 222, 63 (1956).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory for Cell Physiology, Veterans Administration Hospital, San Fernando

    SILVIO FIALA

  2. Department of Biochemistry, University of Southern California, Los Angeles

    SILVIO FIALA

  3. Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania

    EMERICH FIALA

Authors
  1. SILVIO FIALA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. EMERICH FIALA
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

FIALA, S., FIALA, E. Induction of Tyrosine Transaminase in Rat Liver by Actidione. Nature 210, 530–531 (1966). https://doi.org/10.1038/210530a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/210530a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing