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Morphological Transformation of Mouse Embryo Cells in vitro by Murine Sarcoma Virus (Harvey)

Abstract

Murine sarcoma virus (Harvey) produces characteristic changes in cultures of C57BL mouse embryo cells. Some of the cells become spindle-shaped and stain vividly with acridine orange. The transformed cells continuously produce virus in vitro and give tumours on inoculation into adult C57BL mice. The changes are similar to those produced by the Moloney strain of MSV.

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References

  1. Harvey, J. J., Nature, 204, 1104 (1964).

    Article  ADS  CAS  Google Scholar 

  2. Moloney, J. B., “Some Recent Developments in Comparative Medicine” in Symposium, WHO and Zool. Soc., London, June (1965).

  3. Chesterman, F. C., Harvey, J. J., Dourmashkin, R. R., and Salaman, M. H., Cancer Res., 26 (Part 1), 1759 (1966).

    CAS  PubMed  Google Scholar 

  4. Mahy, B. W. J., Harvey, J. J., and Rowson, K. E. K., Tex. Rep. Biol. Med., 24, 620 (1966).

    Google Scholar 

  5. Hartley, J., and Rowe, W. P., Proc. U.S. Nat. Acad. Sci., 55, 780 (1966).

    Article  ADS  CAS  Google Scholar 

  6. Ting, R. C., Virology, 28, 783 (1966).

    Article  CAS  Google Scholar 

  7. Bernhard, W., Cancer Res., 26, 712 (1960).

    Google Scholar 

  8. Temin, H. M., and Rubin, H., Virology, 6, 669 (1958).

    Article  CAS  Google Scholar 

  9. Dougherty, R. M., and Rasmussen, R., Nat. Cancer Inst. Monograph 17, 337 (1964).

  10. Brit. Emp. Cancer Campaign for Res., London, Forty-third Ann. Rep., 169 (1965).

  11. Gross, L., Acta Haematol., 35, 200 (1966).

    Article  CAS  Google Scholar 

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SIMONS, P., DOURMASHKIN, R., TURANO, A. et al. Morphological Transformation of Mouse Embryo Cells in vitro by Murine Sarcoma Virus (Harvey). Nature 214, 897–898 (1967). https://doi.org/10.1038/214897a0

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