Abstract
N-(DL-seryl)-N′-(2,3,4-trihydroxybenzyl)-hydrazine (HCl) (Ro 4-4602) is a strong inhibitor of decarboxylase of aromatic amino-acids in vivo and in vitro1,2. The drug counteracts the increase of 5-hydroxytryptamine which is induced by 5-hydroxytryptophan less markedly in the brain than in extracerebral organs. Small doses of Ro 4-4602 have even seemed to enhance this transformation in the brain; this effect could not be explained3,4.
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References
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BARTHOLINI, G., BURKARD, W., PLETSCHER, A. et al. Increase of Cerebral Catecholamines caused by 3,4-Dihydroxyphenylalanine after Inhibition of Peripheral Decarboxylase. Nature 215, 852–853 (1967). https://doi.org/10.1038/215852b0
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DOI: https://doi.org/10.1038/215852b0
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