Abstract
WE have made a study of a virus preparation which shows some promise as a potentially safer live smallpox vaccine. The virus, called the DIs strain, is a highly attenuated mutant of dermovaccinia virus which has been isolated1 by successive 1 day egg passages of the DIE virus—a strain at present authorized for smallpox vaccination in Japan. The DIs strain is characterized by the production of tiny pocks on chicken chorioallantoic membrane and is distinguished from DIE by its reaction to fluorocarbon (unpublished results). DIs is not pathogenic for mice, guinea-pigs or rabbits, and produces more interferon when irradiated with ultra-violet light and inoculated onto chick embryo fibroblast cultures2. We have studied the pathogenicity of DIs in monkeys and the immunogenicity of the strain in rabbits and monkeys.
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References
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KITAMURA, T., KITAMURA, Y. & TAGAYA, I. Immunogenicity of an Attenuated Strain of Vaccinia Virus on Rabbits and Monkeys. Nature 215, 1187–1188 (1967). https://doi.org/10.1038/2151187a0
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DOI: https://doi.org/10.1038/2151187a0
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