Abstract
SEVERAL permanent tissue culture lines have been established from the peripheral blood of leukaemic patients at this institute. New antigens have been demonstrated on human leukaemic cells, and antibodies directed against these antigens have been detected in the patients' sera1. We have recently shown that in ICI 101 the antigenicity detectable when the cells are first taken from the blood can still be detected after several months in culture2. We report here data suggesting not only that this antigenicity can be preserved, but that it can be increased by culturing the cells in vitro.
Similar content being viewed by others
Article PDF
References
Dore, J. F., Motta, R., Marholev, L., Hrsak, Y., Colas de la Noue, H., Seman, G., De Vassal, F., and Mathe, G., Lancet, ii, 1396 (1967).
Belpomme, D., Seman, G., Dore, J. F., Venuat, A. M., Berumen, L., Le Borgne de Kaouel, C., and Mathe, G., Europ. J. Cancer, 5, 55 (1969).
Le Borgne de Kaouel, C., Belpomme, D., Dore, J. F., Aubert, C., and Granjon, D., Rev. Fr. Et. Clin. Biol., 14 (1969).
Moller, G., J. Exp. Med., 114, 415 (1961).
Klein, E., and Klein, G., J. Nat. Cancer Inst., 32, 547 (1964).
Old, L. J., Boyse, E. A., Geering, G., and Oettgen, H., Cancer Res., 28, 1288 (1968).
Motta, R., Rev. Fr. Et. Clin. Biol., 13, 713 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BELPOMME, D., LE BORGNE DE KAOUEL, C., AJURIA, E. et al. Increase in Antigenicity of Permanent Tissue Culture Lines ICI 101, ICI 104 and ICI 202 established from Human Leukaemic Blood. Nature 222, 890 (1969). https://doi.org/10.1038/222890a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/222890a0
This article is cited by
-
Immunology and colonic cancer: Cancer immunotherapy results in leukemias-experimental and clinical approaches to the treatment of solid tumors
Diseases of the Colon & Rectum (1973)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.