Abstract
WE have investigated the effect of antilymphocyte serum (ALS) on the humoral antibody response, in rabbits, which readily produce large amounts of circulating antibody to well defined antigens. ALS was made by injecting a horse intramuscularly with a mixture of 2 × 109 thymus and lymph node cells from Himalayan rabbits, mixed with incomplete Freund's adjuvant. Seven days later the same number of cells, this time from white New Zealand (NZ) rabbits were given, followed after 14 days by a similar immunization. The horse was bled a week later. The same horse had also been simultaneously immunized with mouse lymphoid cells and the antimouse component was active as an immunosuppressant.
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STEWART, P., BELL, R. Selective Suppression of Cell Mediated Immunity by Equine Anti-rabbit Lymphocyte Serum. Nature 227, 279 (1970). https://doi.org/10.1038/227279a0
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DOI: https://doi.org/10.1038/227279a0
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