Abstract
α-AMANITIN, a bicyclic polypeptide from the toadstool Amanita phalloides1, is known specifically to inhibit the DNA-dependent RNA polymerase of mammalian cells by interaction with the enzyme rather than with the DNA template2,3. No influence of the toxin on the replication of a number of DNA or RNA-containing viruses has been found so far (ref. 4 and personal communication from L. Philipson). Actinomycin, which reacts with the DNA template and so impairs the DNA-dependent RNA polymerase reaction, depresses the multiplication of influenza viruses but does not interfere with the replication of most of the other RNA-containing viruses5–7. Because the mode of action of this antibiotic on the synthesis of influenza viruses is still obscure, we extended our studies to the action of α-amanitin on the multiplication of this virus group.
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ROTT, R., SCHOLTISSEK, C. Specific Inhibition of Influenza Replication by α-Amanitin. Nature 228, 56 (1970). https://doi.org/10.1038/228056a0
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DOI: https://doi.org/10.1038/228056a0
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