Abstract
VIRUS-LIKE particles in tissues of leukaemic and normal guinea pigs have been demonstrated repeatedly1–5. Tumour cells contain intracisternal particles resembling mouse intracisternal A particles3, and extracellular virus-like particles are found in tissues of leukaemic guinea pigs. To the best of our knowledge, a convincing micrograph of a virus-like particle budding from the surface of a guinea pig tumour cell (in vivo) has never been published. In a separate study (J.E.D. and K.P., in preparation), it has been concluded that the guinea pig leukaemia virus1–3 results from the release of intracisternal A particles from dying tumour cells.
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References
Opler, S. R., J. natn. Cancer Inst., 38, 797 (1967).
Nadel, E., Banfield, W., Burstein, S., and Tousimis, A. J., J. natn. Cancer Inst., 38, 979 (1967).
Feldman, D. G., and Gross, L., Cancer Res., 30, 2702 (1970).
Ma, B. I., Swartzendruben, D. C., and Murphy, W. H., Proc Soc. exp. Biol. Med., 130, 586 (1969).
Andersen, H. K., and Jeppersen, T. H., J. natn. Cancer Inst., 49, 1403 (1972).
Hsiung, G. D., J. natn. Cancer Inst., 49, 567 (1972).
Gross, P. A., Fong, C. Y. K., and Hsiung, G. D., Proc. Soc. exp. Biol. Med., 143, 367 (1973).
Rhim, J. S., Duh, F. G., Cho, H. Y., Wuu, K. D., and Vernon, M. L., J. natn. Cancer Inst., 51, 1327 (1973).
Nayak, D. P., and Murray, P. R., J. Virol., 12, 177 (1973).
Bernhard, W., Cancer Res., 20, 712 (1960).
Committee, J. natn. Cancer Inst., 37, 395 (1966).
Dalton, A. J., J. natn. Cancer Inst., 49, 323 (1972).
Dalton, A. J., and Haguenau, F., Ultrastructure of animal viruses and bacteriophages, 255 (Academic Press, New York, 1973).
Nermut, M. V., Frank, H., and Schafer, W., Virology, 49, 345 (1972).
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DAHLBERG, J., PERK, K. & DALTON, A. Virus-like particles induced in guinea pig cells by 5-bromo-2′-deoxyuridine are morphologically similar to murine B-type virus. Nature 249, 828–830 (1974). https://doi.org/10.1038/249828a0
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DOI: https://doi.org/10.1038/249828a0
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