Abstract
EVIDENCE exists indicating that functionally different subsets of T lymphocytes are activated during the in vitro allograft response. Thus, the T cells responding primarily by proliferation in the mixed lymphocyte culture (MLC) may be distinct from the T cells which differentiate to killer cells and display specific target cell lysis (CML)1–3. The biological properties of the T-cell subsets involved are incompletely known. Adult thymectomy (ATX) in mice and rats alters certain T lymphocyte mediated functions. Spleen T cells forming rosettes with sheep erythrocytes disappear as soon as 5 d after ATX4,5. Lymphocyte with high amounts of surface θ antigen are depleted from the spleen within a few weeks after the operation (Ref. 6 and C. Fournier and J. F. B., unpublished).
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ANDERSSON, L., HÄYRY, P., BACH, M. et al. Differences in the effects of adult thymectomy on T-cell mediated responses in vitro. Nature 252, 252–254 (1974). https://doi.org/10.1038/252252b0
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DOI: https://doi.org/10.1038/252252b0
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