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In vitro sensitisation to dinitrochlorobenzene in guinea pigs

Nature volume 252, pages 748–749 (1974)Cite this article

Abstract

ACCORDING to Medawar's concept of peripheral sensitisation1,2 the induction phase of contact sensitivity may consist of a sequence of three stages. These are the formation of antigen by conjugation of the hapten with skin proteins; the recognition of this antigen by circulating lymphocytes and the activation of these cells passing by the site of antigen application; and the proliferation and differentiation of these activated lymphocytes in the draining lymph node resulting in development of memory and affector cells.

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Authors and Affiliations

  1. Department of Experimental Medicine, F. Hoffmann-La Roche and Co. Ltd, CH-4002, Basel, Switzerland

    L. POLAK

  2. Hautklinik der Westfälischen, Wilhelms-Universität, Von-Esmarch-Str. 56, D-44 Münster, West Germany

    E. MACHER

Authors
  1. L. POLAK
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  2. E. MACHER
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POLAK, L., MACHER, E. In vitro sensitisation to dinitrochlorobenzene in guinea pigs. Nature 252, 748–749 (1974). https://doi.org/10.1038/252748a0

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