Abstract
LITTLE is known about the biological effects of vinyl chloride monomer (VCM) despite its wide industrial use. In 1973, thousands of workers were involved in producing, processing and moulding VCM into 15 billion pounds of its polymer (PVC)1. Angiosarcoma, a rare liver cancer, has recently been linked to occupational exposure in man2 and long term inhalation of low doses in animals3. Occupational vinyl chloride exposure has also been associated with increased incidence of hepatic cirrhosis, splenomegaly, decreased bromosulphalein clearance from blood and acro-osteolysis4,5. Reports of acute hepatic injury after vinyl chloride inhalation are limited and the findings relatively nonspecific6,7.
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JAEGER, R., REYNOLDS, E., CONOLLY, R. et al. Acute hepatic injury by vinyl chloride in rats pretreated with phenobarbital. Nature 252, 724–726 (1974). https://doi.org/10.1038/252724a0
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DOI: https://doi.org/10.1038/252724a0
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