Abstract
BONE growth and remodelling depend on resorption and deposition at the local level. The balance between these two processes seems to be modulated by the peptide hormones PTH and calcitonin. Parathyroid hormone (PTH) has been shown to induce bone resorption both in vivo1 and in vitro2, whereas calcitonin (CT) inhibits this process3. Recent studies suggest that both agents act on cellular mechanisms through a second messenger. Thus, it has been demonstrated that exposure of mouse calvaria to PTH or CT can lead to an increase in cyclic AMP content4,5. In addition, dibutyryl cyclic AMP can by itself induce bone resorption2.
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WONG, G., COHN, D. Separation of parathyroid hormone and calcitonin-sensitive cells from non-responsive bone cells. Nature 252, 713–715 (1974). https://doi.org/10.1038/252713a0
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DOI: https://doi.org/10.1038/252713a0
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