Abstract
AGGREGATION chimaeras between strains of mice differing in body size may be used to determine whether the regulation of growth is determined by the relative proportions of cells deriving from the constituent strains. Should this be so, several questions arise; is growth regulated by the proportions in the body as a whole, or is the cellular composition of particular organs (or tissues) more critical? If critical organs or tissues are established, is the regulation then a systemic property, or does the response of other organs and tissues depend further on their own cellular composition? We describe here preliminary findings which indicate the answers to some of these questions and suggest ways of answering the others.
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References
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ROBERTS, R., FALCONER, D., BOWMAN, P. et al. Growth regulation in chimaeras between large and small mice. Nature 260, 244–245 (1976). https://doi.org/10.1038/260244a0
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DOI: https://doi.org/10.1038/260244a0
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