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Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone

Nature volume 263, pages 137–140 (1976)Cite this article

Abstract

SOMATOMEDINS are growth hormone-dependent polypeptides that have been proposed as the mediators of the peripheral actions of growth hormone on skeletal tissue1. Several polypeptides with somatomedin activity in vitro, including somatomedins A, B and C and non-suppressible insulin-like activity soluble in acid ethanol (NSILA-s)2–4, have been isolated from human plasma. Unique among polypeptide hormones, the somatomedins circulate in human blood complexed to binding proteins of larger molecular weight2,4–7. We report here the specific binding of a somatomedin-like polypeptide to distinct protein fractions in rat serum and further demonstrate that the pattern and level of this binding is dependent on growth hormone. We postulate that specific binding of somatomedin modulates the peripheral effects of somatomedin activity.

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Author notes

  1. KENNETH L. COHEN

    Present address: Department of Medicine, Yale University, New Haven, Connecticut, 06520

Authors and Affiliations

  1. Endocrinology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

    ALAN C. MOSES, S. PETER NISSLEY & KENNETH L. COHEN

  2. Diabetes Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, 20014

    MATTHEW M. RECHLER

Authors
  1. ALAN C. MOSES
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  2. S. PETER NISSLEY
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  3. KENNETH L. COHEN
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  4. MATTHEW M. RECHLER
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MOSES, A., PETER NISSLEY, S., COHEN, K. et al. Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone. Nature 263, 137–140 (1976). https://doi.org/10.1038/263137a0

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