Abstract
WITH a few exceptions1–6, the mammalian testis is known to differentiate in the presence of a Y chromosome7, but the mechanism(s) involved remains unknown. Increasing experimental evidence shows that the testis-determining gene product is a plasma membrane protein known as H–Y antigen8. Several investigators have demonstrated that the gene(s) controlling H–Y antigen expression are located on the Y chromosome9,10. We now report the absence of H–Y antigen in 46 XY pure gonadal dysgenesis (PGD) in which patients have female internal and external genitalia and ‘streak’ gonads.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cleveland, W. W. & Chang, G. C. Pediatrics 36, 892–898 (1965).
Cattanach, B. M., Pollard, C. E. & Hawkes, S. G. Cytogenetics 10, 318–337 (1971).
DeLa Chapelle, A. Am. J. hum. Genet. 24, 71–105 (1972).
Wachtel, S. S. et al. New Engl. J. Med. 295, 750–754 (1976).
Saenger, P. et al. J. clin. Endocr. Metabol. 43, 1234–1239 (1976).
Hamerton, J. L. et al. J. Reprod. Fert. Suppl. 7, 25–51 (1969).
Welshons, W. J. & Russell, L. B. Proc. natn. Acad. Sci. U.S.A. 45, 560–566 (1959).
Wachtel, S. S., Ohno, S., Koo, G. C. & Boyse, E. A. Nature 257, 235–236 (1975).
Bennett, D. et al. Nature 257, 236–238 (1975).
Wachtel, S. S. et al. New Engl. J. Med. 293, 1070–1072 (1975).
Goldberg, E. H., Boyse, E. A., Bennett, D., Scheid, M. & Carswell, E. Nature 232, 478–480 (1971).
Espiner, E. A., Veale, A. M. O., Sands, V. E. & Fitzgerald, P. H. New Engl. J. Med. 283, 6–11 (1970).
Mittwoch, U. J. med. Genet. 14, 335–338 (1977).
Sternberg, W. H., Barclay, D. L. & Kolepfer, H. W. New Engl. J. Med. 278, 695–700 (1968).
Wachtel, S. S. et al. Nature 264, 638–639 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GHOSH, S., SHAH, P. & GHARPURE, H. Absence of H–Y antigen in XY females with dysgenetic gonads. Nature 276, 180–181 (1978). https://doi.org/10.1038/276180a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/276180a0
This article is cited by
-
46,XY gonadal dysgenesis: Isoncogenesis related to H-Y phenotype or breast development?
Human Genetics (1985)
-
Variability in serologically detected male antigen titer and some resulting problems: A critical review
Human Genetics (1984)
-
The recognition of abnormal sex chromosome constitution by HLA-restricted anti-H-Y cytotoxic T cells and antibody
Immunogenetics (1983)
-
Intersex problems in the neonate
The Indian Journal of Pediatrics (1982)
-
H-Y antigen studies in thirty patients with abnormal gonadal differentiation: Correlations among sex chromosome complement, H-Y antigen, and gonadal type
Japanese Journal of Human Genetics (1981)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
