Abstract
The extracellular patch clamp technique developed by Neher et al.1 to record the responses of single channels in skeletal muscle has provided firm evidence for the two-state nature of the conductance event in nicotinic endplate channels. We report here the use of the extracellular patch technique to record single-channel responses from tissue-cultured chick skeletal muscle cells. The temperature dependence of channel conductance and gating kinetics shows no evidence of discontinuous behaviour between 17 and 37 °C.
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References
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Nelson, D., Sachs, F. Single ionic channels observed in tissue-cultured muscle. Nature 282, 861–863 (1979). https://doi.org/10.1038/282861a0
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DOI: https://doi.org/10.1038/282861a0
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